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Cyclin-dependent protein kinases and cell cycle regulation in biology and disease

Nature
Cyclin Dependent Kinases (CDKs) are closely connected to the regulation of cell cycle progression, having been first identified as the...
1 week ago

Shear-Dependent Platelet Aggregation: Mechanisms and Therapeutic Opportunities

Frontiers
Recent studies have emphasized the importance of shear forces generated from blood flow, that primarily drive platelet activation and aggregation in thrombosis.
6 months ago

How to Spot the Signs of Codependency

Verywell Mind
Codependency in a relationship is when each person involved is mentally, emotionally, physically, and/or spiritually reliant on the other.
7 months ago

A low-rank method for parameter-dependent fluid-structure interaction discretizations with hyperelasticity

Wiley Online Library
In this paper, we propose a new method that extends this framework to nonlinear parameter-dependent fluid-structure interaction problems by means of the Newton...
4 months ago

Wheat Germination Is Dependent on Plant Target of Rapamycin Signaling

Frontiers
Our data show that rapamycin inhibits germination of wheat seeds and of their isolated embryos in a dose-dependent manner.
6 months ago

Alumni group seeks change in Cornell Code, university's definition of Antisemitism

The Ithaca Journal
A group of Cornell alumni have prompted the Ivy to change its code of conduct following antisemitic threats on its campus.
13 months ago

Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response

ScienceDirect.com
Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined.
18 months ago

Pulmonary Toxicity of Boron Nitride Nanomaterials Is Aspect Ratio Dependent

ACS Publications
We investigated the pulmonary impact and clearance of two-dimensional hexagonal boron nitride (h-BN) nanosheets and boron nitride nanotubes (BNNTs) in mice.
13 months ago

Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ

Science | AAAS
Heme is the endogenous ligand for the constitutively repressive REV-ERB nuclear receptors, REV-ERBα (NR1D1) and REV-ERBβ (NR1D2),...
47 months ago

Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction

BioMed Central
Tirzepatide is the first dual GIP/GLP-1 receptor co-agonist approved for the treatment of type 2 diabetes in the USA, Europe, and the UAE.
28 months ago