WO2011019382A1 - Orthodontic methods and devices - Google Patents
Orthodontic methods and devices Download PDFInfo
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- WO2011019382A1 WO2011019382A1 PCT/US2010/002202 US2010002202W WO2011019382A1 WO 2011019382 A1 WO2011019382 A1 WO 2011019382A1 US 2010002202 W US2010002202 W US 2010002202W WO 2011019382 A1 WO2011019382 A1 WO 2011019382A1
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- perforations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C3/00—Dental tools or instruments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
- A61B17/1604—Chisels; Rongeurs; Punches; Stamps
Definitions
- the present invention provides methods for performing dental procedures including orthodontic procedures and devices useful for performing such procedures.
- braces that are installed to the teeth and which include wires and other tension devices, such as rubber bands and coils, to exert a continual tension on the tooth to move the tooth or teeth in to the desired position.
- wires and other tension devices such as rubber bands and coils
- Orthodontic cases are generally divided into two categories according to the direction the tooth movements are made, either expansion where crowded and crooked teeth are moved toward the periphery of the outline of the jawbone or retraction where one or more teeth are removed to create more room in the jaw. To align the teeth, one or more teeth may be moved in the direction of spaces created.
- Conventional orthodontics is performed by moving the root of a tooth through its surrounding bone in the jaw.
- the bone of the jaw has a hard outer shell, called the cortical plate or cortical bone, and a softer interior called the medullary bone.
- the medullary bone has a good blood supply and is highly populated with
- the medullary bone responds relatively dramatically and timely to physical insult including the forces used to move teeth.
- the root of the tooth must be moved through the bone surrounding the tooth, the alveolar bone consisting of the medullary bone and surrounding cortical plates that comprise the upper and lower jaws.
- the alveolar bone remodels around a tooth being moved in response to pressure and tension around the roots of teeth. .
- bone resorption occurs on the pressure side of the root surface in the direction in which the tooth is moving.
- Bone deposition or new bone formation occurs on the tension side of the root surface in the direction away from which the tooth is being moved.
- the root of a typical tooth is usually so large in diameter that it occupies most of the space between the lingual cortical plate on the inside of the jaw and the facial cortical plate on the outside of the jaw. As a result, much of the root of a tooth is covered with hard cortical plate and with very little soft medullary bone.
- a major drawback to conventional orthodontics is the long treatment time during which braces must be worn. Corticotomy has been used for several decades to attempt to shorten orthodontic treatment times.
- the term refers to a bony cut or perforation that extends through the entire thickness of the cortical plate of the alveolus and into the underlying medullary bone or, if no medullary bone is present under the cortical plate, it refers to a bony cut or perforation that extends through most of the thickness of the cortical plate, but not its entire thickness.
- Corticotomy has been used in difficult adult cases as an alternative to conventional orthodontic treatment or orthognathic surgery. It has been claimed that by combining a corticotomy procedure with orthodontics, it is possible to complete treatment in a shorter period of time due to the ability to move teeth more rapidly. The mechanism of this action is not clear.
- Several authors have described rapid tooth movement observed in conjunction with corticotomy as movement by "bony block.” Based on this concept, a fissure is made through the cortical plate that surrounds a tooth, so that this tooth will now be in a block of bone connected to surrounding bone only through the medullary bone. The tooth is the "handle" by which this block of bone can be moved.
- Others have related the effect of corticotomy- facilitated orthodontics to the repair mechanism that is observed following injury of bone. After bone injury, accelerated bone turnover and decreases in regional bone density have been described.
- Scott, U.S. Patent 7,329,122 and Scott, U.S. Patent Publication No. 2008/0102415 teach using flapless corticotomy using long needles. This procedure requires fabrication of a guide to determine the best places for application of cortical perforations. Scott proposes using needles to produce deep and narrow perforations that may be damaging to tooth roots and surrounding tissues. To compensate for this side effect, Scott designed a complex template as a guide for safe application of multiple cortical plate perforations. This technology makes the application of these procedures very difficult and unpractical.
- cytokines and other inflammatory markers such as prostaglandin E2 (Saito et al, Am J Orthod Dentofacial Orthop (1991) 99(3);226-40) may activate bone remodeling characterized by bone resorption in the compression region and bone deposition in the tension region of the periodontal ligament (PDL) (Davidovitch et al, Dent Clin North Am (1988) 32(3).-411-35; Garlet et al., Eur J Oral Sci (2007) 115(5).355-62).
- PDL periodontal ligament
- cytokines that promote osteoclast formation and activation such as IL-I, IL-6, and TNF ⁇ (Glantschnig et al. Cell Death Differ (2003) 10(10). 1165-77; Seidenberg, et al, Pharmacol Res (2004) 50(2). 151-6; Yao et al, J Biol Chem (2008) 283(15):9917-24), have also been found in crevicular fluid during orthodontic tooth movement (Basaran et al, Am J Orthod Dentofacial Orthop 2006; 130:El-6; Uematsu et al, J Dent Res. 1996; 75:562-567 ).
- the present invention is based in part upon the discovery that limited and shallow perforations of the buccal cortical plate of the maxilla increase the expression of
- the present invention is also based in part upon the discovery that deep cortical perforations are not required to induce inflammation capable of accelerating tooth movement.
- the methods of the present invention do not require any template to prevent side effects associated with deep and narrow needles.
- the present invention is also based in part upon the discovery that the site of perforation is relatively unimportant to induce inflammation capable of accelerating tooth movement. In fact, the present invention demonstrates that both the site of perforation and the number of multiple perforations is relatively unimportant. Hence, the methods of the present invention are safer, more comfortable for the patient, present less risk of infection and require less recovery time.
- the present invention provides a method of moving a tooth to a desired positions within a patient's mouth comprising using osteoperforation-facilitated orthodontics.
- the method includes perforating or pricking tissue in the oral cavity sufficient to induce an inflammatory response in the tissue.
- An inflammatory response may be identified readily by the increased presence of certain cytokines such as certain interleukins or the increased presence of certain cells such as macrophages and monocytes as is well known in the art.
- the method further includes providing an orthodontic appliance on or near the tooth to be moved to exert force on the tooth toward the desired position.
- the orthodontic appliance may be installed on the tooth prior to or subsequent to the perforating or pricking, such as for instance, about one, two, three or four days or more, or one, two, three, four, five, ten or more weeks prior to or subsequent to the perforating or pricking.
- the methods may result in a reduction in the time required to move a tooth from a first position to a second position of at least about 5%, 10%, 20%, 25%, 30%, 40%, 50%, 60%, 75%, 80%, 90% or more as compared to the length of time required to move a tooth from a first position to a second position in instances where no perforations are provided.
- orthodontic appliances If orthodontic appliances have not been installed prior to the perforations they can be installed after the perforations as desired.
- the orthodontic appliances once activated, may be adjusted periodically, as needed, to move the teeth toward their desired positions.
- the methods of the present invention may be repeated as necessary to maintain a sufficient inflammatory response to expedite tooth movement. For instance, the methods may repeated daily, one, two, three, four or more times per week, or one, two, three, four, five, eight, ten, twelve, fifteen, twenty or more times per month.
- the orthodontic appliances must be adjusted frequently enough to complete the major orthodontic movements.
- the method features making one or more shallow bone perforations in the tissue of the oral cavity.
- the perforations may be made, for instance, in any area of the maxilla or mandible. Preferably about 1 to 100, 1 to 50, 1 to 40, 1 to 25, 1 to 20, 1 to 15, 1 to 10, or 2, 3, 4, 5, 6, 7, 8 or more perforations are made in the tissue of the oral cavity.
- the perforations may be about 0.1 to 10 mm diameter, preferably 0.2 to 8 mm diameter, more preferably 0.3 to 7 mm diameter, 0.4 to 5 mm diameter, 0.5 to 3.0 mm diameter, or 1.0 to 1.5 mm diameter.
- the perforations may be about 0.5 to 15 mm deep, preferably 0.75 to 10 mm deep, and more preferably 1 to 8 mm deep, and still more preferably 3 to 6 mm deep.
- the perforations do not penetrate the medulary bone. Such perforations are sufficient to enhance the bone remodeling process and subsequently accelerate tooth movement.
- the perforations are made using the devices and kits described herein.
- a shallower perforation of, for instance, 1 -2 mm may be placed in thinner bone such as the bone closer to alveolar crest while deeper perforations, for instance, greater than 3 mm in depth may be placed in thicker bone such as the bone closer to the middle or apical part of the roots.
- a pilot drill or soft tissue punch may be necessary.
- 2 or 3 perforations medial and distal of the tooth or teeth that are to be moved is enough.
- the perforations may be placed about 1 to 5 mm or 2 to 3 mm from the alveolar crest. Further, the perforations may be placed about 0.1 to 10 mm, 0.5 to 5 mm or 1 to 2 mm distance from each other.
- the perforations may be placed in attached gingiva areas for simplicity and reduction of discomfort.
- perforations may be made using a relatively slow speed handpiece having burs.
- the burs preferably also have markers to show different depths.
- a gauze may be placed in the area of the perforations for a period of time, such as 1-10, 2-6 or 3-4 minutes.
- the patient may use a chemical antiseptic such as, for example, Peridex, for a few days or a week or two weeks after the perforations.
- a chemical antiseptic such as, for example, Peridex
- other medication is not necessary unless the systemic health of the patient necessitates.
- the method features performing osteoperforations by rinsing the oral cavity with a a chemical antiseptic such as, for example, Peridex, applying a local anesthetic such as lidocaine 2% or carbocaine and making small perforations having a bone depth of preferably about 0.5 to 10 mm, 0.75 to 5 mm or 1-3 mm.
- the perforations may be made, for instance, in any area of the maxilla and mandible.
- Preferably about 1 to 100, 1 to 50, 1 to 40, 1 to 25, 1 to 20, 1 to 15, 1 to 10, or 2, 3, 4, 5, 6, 7, 8 or more perforations are made in the tissue of the oral cavity.
- the perforations may be about 0.1 to 10 mm diameter, preferably 0.2 to 8 mm diameter, more preferably 0.3 to 5 mm diameter, 0.4 to 3 mm diameter or 0.5 to 1.5 mm diameter.
- the perforations may be placed using a hand instrument such as a hand drill.
- the hand drill has markers or stops that show depths.
- a shallower perforation of, for instance, 1 -2 mm may be placed in thinner bone such as the bone closer to alveolar crest while deeper perforations, for instance, greater than 3 mm in depth may be placed in thicker bone such as the bone closer to the middle or apical part of the roots.
- a pilot drill or soft tissue punch may be necessary.
- 2 or 3 perforations medial and distal of the tooth or teeth that are to be moved are enough.
- the perforations may be placed about 1 to 5 mm or 2 to 3 mm from the alveolar crest. Further, the perforations may be placed about 0.1 to 10 mm, 0.5 to 5 mm or 1 to 2 mm distance from each other.
- the perforations may be placed in attached gingiva areas for simplicity and reduction of discomfort. In some instances, in areas where, for instance due to dense bone or difficult location of tooth, direct application of a hand instrument is difficult or impossible, perforations may be made using a relatively slow speed handpiece having burs. The burs preferably also have markers or stops to show different depths.
- a gauze may be placed in the area of the perforations for a period of time, such as about 1-10, 2-6 or 3-4 minutes.
- the patient may use a chemical antiseptic such as, for example, Peridex, for a few days or a week or two weeks after the perforations. In many instances, other medication is not necessary unless the systemic health of the patient necessitates.
- the osteoperforations are performed near to or as close as possible to the time of tooth movement. In some embodiments, the osteoperforations are performed after adjusting an orthodontic appliance.
- the perforations are made sufficient in number and sufficient in size to increase the expression of one or more inflammatory markers in tissue near to, proximate to, or even distal from the tooth to be moved or in tissue near to, proximate to, or even distal from the tissue in which the perforations are made.
- the subject tissue may be for instance, within about 1 mm of the tooth to be moved, or the subject tissue may be within 2 mm, 3 mm, 4 mm, 5 mm, 6 mm, 8 mm, 10 mm, 12 mm, 15 mm or 20 mm or even farther from the tooth to be moved.
- the expression of the one or more inflammatory markers may be increased by about 10%, 20%, 25%, 30%, 40%, 50%, 60%, 75%, 80%, 90%, 100%, 125%, 150%, or even by two fold, three fold, four fold, five fold, ten fold or more as compared to the expression of the one or more inflammatory markers prior to any
- the increase in the expression of the one or more inflammatory markers may be measured at any time after the first perforation is performed, such as, for instance, about 1 hour, 3 hours, 6 hours, 12 hours, 18 hours, 24 hours, 36 hours, 48 hours, 72 hours, or even 4, 5, 6, 7, 10, 12, 14, or 21 days after the first perforation is made.
- inflammatory markers may be, for instance, one or more cytokines, one or more chemokines, or one or more inflammatory receptors.
- the one or more inflammatory markers may be, for instance, one or more of markers of lymphocytes such as CCL20 or CCRl , one or more markers of T cells such as LTa, IL-3, CCL5, CCR5, CX3CR1, IL-18rb, or IL-lrl, one or more markers of monocytes such as IL-I, IL-6, 111 1, IL-18, or IL-6ra, or one or more markers of macrophages such as IL- 1,TNF, IL-6, IL-11, IL- 18, IL13ral,CCL2, CCL9, CCL12, CCR5, or IL-6ra.
- the perforations are made sufficient in number and sufficient in size to increase osteoclast activity on the surface of bone near the tooth to be moved, such as, for instance the alveolar bone surface.
- Such osteoclast activity may be measured by any known methods such as for instance, identification of the number of TRAP-positive (tartrate-resistant acidic phosphatase) osteoclasts.
- the number of TRAP-positive osteoclasts may be increased by about 10%, 20%, 25%, 30%, 40%, 50%, 60%, 75%, 80%, 90%, 100%, 125%, 150%, or even by two fold, three fold, four fold, five fold, ten fold or more as compared to the number of TRAP-positive osteoclasts prior to any perforations.
- the increase in the number of TRAP-positive osteoclasts may be measured at any time after the first perforation is performed, such as, for instance, about 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 12 hours, 18 hours, 24 hours, 36 hours, 48 hours, 72 hours, or even 4, 5, 6, 7, 10, 12, 14, or 21 days after the first perforation is made.
- the present invention features a device for osteoperforation, that is, a device for making minute perforations in bone such as the alveolar bone.
- the shallow perforations that may be, for instance, about 2-6 mm in length and 1 to 2 mm in width may be made through the gum into alveolar bone in areas adjacent to the teeth.
- the depth and width of the perforations are controlled by the present invention and the number of perforations.
- the number of perforations can range from one to multiple perforations depending on the bone density. In areas where the bone is denser, more perforations may be necessary.
- the device may be, for instance, a hand held device such as a hand held drill as described herein.
- the present invention features a kit containing the device of the present invention. That is, the kit contains one or more of the necessary components that can be used by a dentist or orthodontist to readily and conveniently perform the methods of the present invention and speed the movement of a tooth to a new, desired position.
- the kit may contain, for instance, a hand device such as a hand drill, as described herein.
- the kit may further contain, for instance, instructions for operating the hand device or hand drill or instructions for making the desired perforations.
- (C) Changes in number of TRAP-positive cells on the mesial alveolar bone surface of the mesio- palatal root of maxillary first molar. Each value represents the mean +_ SEM of 4 samples. *Signif ⁇ cantly different from C group, ** Significantly different from C, O, and OF groups;/? ⁇ .O5.
- Fig. 4 demonstrates that osteoperforations increase the bone remodeling rate and generalized osteopenia in the entire length of the hemimaxillae.
- A Sagittal sections of maxillae from the four groups viewed under fluorescent microscopy show the rate of bone remodeling in the entire hemimaxilla. The increased intensity of the label in most of the trabecular surface of the OFP group in comparison with other groups indicates that extensive bone remodeling has taken place at 28 days post-treatment.
- White arrows demonstrate the direction of force application
- B Schematic indicating axial sections (1, 2, 3) and coronal sections (a, b, c) used in the analysis.
- Fig. 7 is a photo of a patient's upper oral cavity showing closure of the space shown in Figure 6.
- localized osteoperforations as described in the present invention (2 buccal and 1-2 osteoperforations in the crest of the alveolar bone, the space shown in Figure 6 was closed with molar protraction in only 8 months.
- FIG. 10 is a schematic view of a rotatory perforating device that can be attached to a dental hand piece:
- Figs. 1 IA-I ID are schematic views illustrating the use of the present devices to perform osteoperforation.
- Fig. 12 illustrates the components that can be incorporated into a kit to perform osteoperforation.
- the present methods recognize that the increase in bone remodeling and consequent tooth movement is not dependent on the extensive cutting or mechanical weakening of bone but on the stimulation of an inflammatory reaction.
- the present methods provide a minimally traumatic procedure that still elicits the inflammatory reaction, resulting in bone remodeling and accelerated tooth movement.
- the present methods further provide increasing the rate of tooth movement to reduce the overall orthodontic treatment duration, while extending the range of tooth movement.
- the present methods are less invasive, less traumatic and pose no or only minimal risks for the patient. Therefore, the present methods may be safely performed by any orthodontist and does not require the services of a periodontist or a surgeon.
- the present methods are to be used in combination with orthodontic appliances when there is need for increased range of tooth movement due to severe skeletal discrepancies.
- the present methods provide a simple and novel approach for clinicians to perform osteo- perforations to induce accelerated bone remodeling.
- the present methods are atraumatic without gingival flap, with minimum discomfort performed in a relatively short period of time with minimal side effects. These methods allow accelerated tooth movement in a short period of time in any direction, expanding the range of tooth movement to such an extent that was only possible previously through orthognatic surgery. Due to accelerated bone remodeling, tooth movement in areas that previously were not possible such as atrophic bone, become feasible.
- a stand alone device that may be used in conjunction with slow-speed rotary instruments or may also be utilized with manual drivers is also provided.
- the device may provide one or more of the following: a gingival tissue hole-punch; a high quality disposable (e.g. tungsten-carbide/surgical steel) depth limiting burs with a diameter of 1 to 2mm, and cutting length of for instance, 1, 2, 3, 4, 6, 8 and 10 mm with safe stops, and smooth cuff to prevent damage to soft tissue. Burs may be utilized either with low speed rotary or manual drivers.
- the device may further feature a manual driver capable of engaging and releasing burs.
- the predetermined length of the small drill 17, in the exemplary embodiment, can be 6, 8 or 10 mm while the thickness or diameter may be between 1.5 or 2mm, however other lengths and diameters can be used.
- the hand held perforating device 10 may be used to make perforations in the alveolar bone, as will be described with respect to Figs 1 IA-11C, of a known, predetermined diameter and depth.
- the hand held perforating devices 10 and 20 can be provided to the user in a disposable package as shown in Fig. 9C. As seen in Fig 9C, there is a sealed container 24 that can contain a hand held perforation device 10 or 20 in a sterilized format for one time usage. This package has a container body 26 and a removable cover 28. In Fig. 9D, it can be seen that the cover 28 has been partially peeled back for access to the components contained within the container body 26.
- Fig. 1 IA-I ID there is shown schematic views illustrating the use of the devices of the present invention.
- a normal alveolar bone 44 is illustrated.
- the alveolar bone 44 is part of the jaw bone that accommodates the teeth and which is covered by the gum 46 or gingiva.
- Fig 1 IB there is shown the alveolar bone 44 and gum 46 has been perforated directly by hand held perforating device 10 as described with respect to Fig. 9A. Stop 18 determines the depth of penetration of the perforation that the hand held perforating device 10 will produce inside the bone.
- Fig 11C and 1 1 D demonstrate the steps in using a rotating perforating device 32 that is attached to the dental handpiece 30.
- the rotating perforating device 32 has a shaft 33 having a distal end 35 and a small drill 40.
- As stop 36 is also provided to function as a limiter to the depth of penetration of the small drill 40.
- a soft tissue punch 48 be used before application of a rotating device, see Fig. 11C, especially in places where gum tissue is loose.
- Application of the soft tissue punch 48 with a rotating perforating device 32 may prevent damage to gum.
- the soft tissue punch 48 can create an opening in the gums of the patient so that the later use of a rotating perforation device 32 does not catch up in the gum tissue with the drill 40 so that the drill 40 enters cleanly into the bone 44. In areas where the gum is firmly attached to the bone 44, application of soft tissue punch 48 may not be necessary.
- the rotating perforating device 32 can directly access the bone 44 as illustrated in Fig. 1 ID.
- the device may be provided in a kit.
- the kit may also contain one or more of a disposable local anesthetic carpule, and topical analgesic swabs, a depth gauge probe, and an illustrated detailed instruction manual.
- Fig 12 demonstrates an inventive kit form that can be conveniently used for performing the methods of this invention. It is envisioned that the present kit can be supplied to dentists or orthodontists so that the doctor will have all of the components necessary to carry out the osteoperforation method of the present invention.
- This kit includes a container having therein a local anesthetic 50 (lidocaine HCL 2%), a topical anesthetic 52, a syringe for application of local anesthetic 56, short needles 54, soft tissue punch 48 and different length and widths of hand held perforating devices in disposable packages 24, short modification of hand perforating devices for access to difficult area in disposable packages 20 and different length and widths of small drills for application with dental handpiece 32.
- a local anesthetic 50 lidocaine HCL 2%
- a topical anesthetic 52 for application of local anesthetic 56
- short needles 54 short needles 54
- soft tissue punch 48 soft tissue punch 48
- corticotomy facilitates orthodontic tooth movement by reducing physical constraints or via a mechanism resembling that in bone response to injury. Since inflammation is an underlying mechanism, it is preferable to administer the minimal injury capable of eliciting an inflammatory response.
- Forty-eight rats were fitted with closing coils and subjected to either a 50 cN force to the maxillary first molar (O), the same force after implementation of a soft tissue flap (OF), force plus flap plus three perforations of the cortical plate mesial to the first molar (OFP), or no force (controls: C). Perforations of cortical bone resulted in increased inflammatory reaction as shown by RT-PCR of RNA at 24 h.
- micro-computed tomography, light and fluorescent microscopy, and immunohistochemistry revealed increased rates of tooth movement and bone remodeling.
- the increase in rate of bone remodeling extended beyond the first molar region to the adjacent alveolar bone.
- Shallow perforations of cortical bone are sufficient to stimulate an inflammatory response capable of accelerating bone remodeling and tooth movement. The procedure is easy to perform, minimizes side effects and discomfort, and shortens recovery time.
- Inflammation can alter the physiology and structure of bone by modifying the normal pattern of remodeling through stimulation of bone resorption and formation.
- corticotomy can facilitate orthodontics tooth movement because the surgical design of corticotomies has been greatly influenced by clinicians' mechanistic view of the underlying biological process. If the purpose of corticotomy is to weaken the bone around the tooth, then the surgery should be designed to create a loose block of bone around the tooth to be moved. If, however, the goal of the corticotomy is to accelerate the bone remodeling process by evoking an inflammatory response, then the geometry of the surgical cuts is not so crucial, and the minimal injury that activates the bone repair system would suffice requiring less traumatic surgical design. The current study demonstrates that limited shallow perforations of the buccal cortical plate of the maxilla are sufficient to accelerate the bone remodeling process and therefore tooth movement.
- CCL2 monocyte chemoattractant protein- 1 (Piemonti, et al., Diabetes 2002; 51 :55-65)) and CCR2 (receptor for CCL2 (Luster, N EnglJ Med 1998; 338:436-445; Shireman, J Vase Surg 2007; 45 Suppl A:A48-56))— produced and expressed in endothelial cells, vascular smooth muscle cells, tubular epithelial cells, lymphocytes, and monocyte/macrophages (Piemonti, et al., Diabetes 2002; 51:55-65)— confirm the extensive and massive vascular invasion observed in the OFP group.
- Inflammation can be beneficial by accelerating bone remodeling and tooth movement, however, if uncontrolled it may also have a destructive effect on the periodontium and tooth structure. Root resorption may be affected by osteoperforation. While extensive injury to the cortical plate bone, also referred to as corticotomies, is currently being used to accelerate orthodontic tooth movement in private practice, the present data indicate that this approach could be simplified to minimize deleterious side effects. Therefore, flapless minimal cortical perforations may be used as a means of fine tuning inflammation levels for enhanced tooth movement, enabling orthodontists to provide more efficient treatment to their patients.
- the basic principles of the orthodontic method of this invention are applicable in retraction cases and expansion cases.
- Retraction cases may also require that teeth be expanded, as well, as indicated above. Additionally, since retraction cases normally require the extraction of teeth and move teeth in the opposite direction from the movement of teeth in expansion cases, retraction cases are handled somewhat differently.
- the retraction devices used in the present methods may be constructed out of components and materials used by those skilled in the art to construct orthodontic palatal expansion devices such as shown in U.S. Patent No. 4,347,054 Kraus et al, U.S. Patent No. 4,354,832, Wallshein, U.S. Patent No. 4,433,956, Witzig, U.S. Patent No. 4,482,318, Forster, U.S.
- the animals received three shallow perforations, approximately 0.25 mm in diameter (depth of 0.25 mm), 5 mm mesial to the left first molar using a round bur and hand piece. Animals were checked under general anesthesia twice weekly, and any springs requiring retying (mostly due to continuous eruption of the maxillary incisors) were adjusted. Bone labeling by intraperitoneal injection of calcein (15 mg/kg) was performed on days 0 and 26 and by demeclocycline (25 mg/kg) on day 14.
- Hemimaxillae were collected and fixed in 10% phosphate buffer formalin and demineralized in a sodium formate (6.8%) and formic acid (50%) solution for 6-8 weeks. Following demineralization, specimens were dehydrated in alcohol series, embedded in paraffin, and 5- ⁇ m-thick sections cut and stained with hematoxylin and eosin (H&E).
- H&E hematoxylin and eosin
- Consecutive specimens were immunostained using antibodies for tartarate-resistant acid phosphatase (TRAP; Zymed antibodies, Invitrogen, Carlsbad, CA), a marker of osteoclasts, and Vectastain ABC kit (Vector Laboratories, Burlingame, CA) according to the
- RNA extraction 4 animals from each group were sacrificed by CO 2 narcosis at 24 hours and the hemimaxillae dissected and frozen in liquid nitrogen. Isolation of total RNA was performed using TRIZOL reagent (Life Technologies, New York, NY), and RNA cleanup was performed using RNeasy Mini Kit (Qiagen Sciences, Valencia, CA) as described before (Seraf ⁇ m et al., 2009). All equipment and tools were cleaned with RNaseZap (Sigma, St Louis, MO).
- test groups and controls were assessed by analysis of variance (ANOVA). Pairwise multiple comparison analysis was performed using Tukey's post hoc test. Two-tailed /7-values were calculated;/? ⁇ .05 was set as the level of statistical significance.
- Coil springs were used for mesial movement of the first maxillary molar crown (Fig.
- cytokines showing a 1.6 to 2.7 fold increase (Fig 2A), 5 chemokines showing a 1.6 to 2.8 fold increase (Fig 2B), and 8 receptors showing a 1.7 to 2 fold increase in expression (Fig 2C). All cytokines/cytokine receptors expressed in the OFP group were also expressed in O or OF groups. Expression of cytokines in the contra-lateral side of all groups showed no statistically significant differences from group C (data not shown).
- Osteoperforations increase the rate of bone remodeling and generalized osteoporositv
- the variables in this study will be levels of inflammatory markers and the rate of tooth movement. At each visit, an impression to evaluate the rate of tooth movement will be taken by measuring casts. Crevicular fluid samples will also be taken from the patients at each visit for evaluation of inflammatory markers using a protein array approach. In addition we will measure probing depth (PD), PI (Plaque Index) and gingival index (GI) to assess periodontal status at each visit. At start of each visit after osteoperforation, patients will be evaluated for level of pain or any discomfort. In this regard, patient will be asked to rate on scale of 1 to 10 the magnitude of pain or other sort of discomfort.
- Subjects will be 18 - 40 years of age. This portion of the population is selected because a large portion of patients undergoing orthodontic treatment are within this age range.
- Periodontal evaluation of prospective subjects will be performed by orthodontists in the Clinic of the Department of Orthodontics and include (based on American Association of Peridontists' guidelines) including a full mouth series, and a full mouth probing depth (PD), plaque index (PI) and gingival index (GI) assessment.
- PD full mouth probing depth
- PI plaque index
- GI gingival index
- GCF Gingival Crevicular Fluid
- GCF samples will be collected from each patient at each visit to evaluate
- GCF samples in both the experimental and control groups will be collected between 10:00 am and 12:00 pm. Before any treatment begins, sample of crevicular fluid will be taken from maxillary mesial and distal upper canines that are affected by the retraction. Samples will be taken bilateral mesial and distal to upper canine. Prior to sampling, we will remove supragingival plaque. Cotton rolls will isolate the regions where GCF samples will be taken. The teeth and marginal gingiva will be dried with air before sampling. Filter paper strips will be inserted lmm below the gingival margin into the mesio labial and mesio labial crevices surrounding each tooth for 30 seconds. About 1.2 ⁇ L to 3 ⁇ L of GCF will be collected from each side of the tooth on the paper strip.
- GCF samples will be stored in - 70 0 C refrigerator in a laboratory on 10 th floor , room #1038 NYU College of Dentistry that will be locked.
- Impression will be taken with Alginate.
- the procedure of taking impression will be done before wire placement.
- Anhydrite (CaSO4 ) will be poured over the impression.
- the casts will be labeled (patient number and date) and stored and locked in a laboratory.
- Peri-apical x-ray will be taken at enrollment, the day of the TAD placement and perforation, 3 and 6 months later evaluate the bone situation, estimate the placement of TADs and perforation, and evaluate bone after tiny perforations and tooth movement.
- the subjects' x-ray exposure will be carefully monitored and maintained at safe levels. This study will require no additional x-ray exposure than what would be required with traditional orthodontics treatment.
- the effective doses that subjects will be exposed will be well within the annual effective dose limit of 1 mSv.
- the effective dose for a lateral cephalometric x-ray is 0.002-0.003 mSv.
- the effective dose for a periapical x-ray is 0.001- 0.008 mSv.
- the effective dose for a panoramic x-ray ranges from 0.002-0.03 mSv. (Whaites, Dental Radiography and Radiology, London: Churchill Livingstone Elsevier, 2007;
- the estimated effective dose for a bitewing dental radiograph is 0.038.
- the patient will have a panoramic x-ray (0.03 mSv) at the beginning of treatment.
- the subject will have bitewing dental radiographs (0.038 mSv) taken every 3 months.
- the total effective dose exposure will be much less than the recommended effective dose limit of ImSv.
- Phase 2 [0116] The PI, Co-PI, or the residents assigned to the study will evaluate these conditions of subject's occlusion before initiating phase 2.
- the wire must be, 0.016 ⁇ 0.022 stainless steel and no tooth rotations may bepresent.
- orthodontists will deliver the local anesthetic.
- the local anesthetic that will be is used is lidocaine with 1 : 100,000 epinephrine.
- the dentist will administer an inferior alveolar nerve block (IANB) and a buccal nerve block to anesthetize the tooth to be treated.
- IANB inferior alveolar nerve block
- a 27-gauge, long needle will be used and after multiple negative aspirations, 1.5 ml of anesthetic will be deposited. More anesthetic will be delivered and documented as needed. Patient will be given a complete cleaning at every visit after all measurements.
- TADs mini screw implants
- GAC International mini screw implants
- Surgical perforation procedure will be performed following TADs placement.
- three small holes will be made mesial to 2 n premolar, perpendicular to the tooth. These 3 tiny holes will form a line (facial to palatal) along the bone.
- the coil (GAC International) will be connected to an attachment on canine bracket to the TAD.
- the force will be adjusted to lOOg at all visits.
- An electronic gingival fluid-measuring device the Periotron 8000
- the Periotron 8000 will be used to measure the volume of the GCF samples collected from each patient at every visit.
- We will calibrate the Periotron 8000 with standard volumes of human serum.
- the Periotron 8000 will be calibrated according to the manufacturer's instructions.
- the minimum concentration of for each cytokine must be between 5 pg/mL and 45 pg/mL in each sample for detection using Glass-slide based array method.
- the GCF samples will be placed into microcentrifuge tubes and diluted to 0.1 ml with buffer solution provided in the RayBio® Human Cytokine Antibody Array kit.
- the paper strips must be incubated for 1 hour in the buffer solution at 4°C. Then, we will use centrifugation (14,000 x g for 5 minutes) to collect the fluid from the paper strip.
- Paper strips in sealed microcentrifuge tubes will be labeled and stored at -20 0 C until analysis.
- the microcentrifuge tubes will be labeled with thedate, patient's number, the tooth number from which the sample was collected. Prior to analysis GCF samples, will be thawed and recentrifuged. GCF samples will then be analyzed according to the RayBio® Human Cytokine Antibody Array kit (see appendix II).
- the specific aim is to determine the effect of administering shallow perforations.
- the dependent variables, levels of inflammatory markers will be measured using a Human Cytokine Antibody Array kit, and tooth movement; will be measured using in the casts and analyzed using the t-test. Measurements of casts and Cytokine Antibody Array will be performed by investigators blinded to the group assignment of each patient. Data will be plotted using Excel spreadsheet before statistical analysis.
- results will demonstrate the role of shallow, small perforations in the levels of inflammatory markers and the rate of tooth movement.
- the patients that receive osteoperforation, in addition to orthodontics treatment, will finish their treatment in significantly shorter period of time. This will decrease the potential side effects associated with any lengthy orthodontics treatment such as root resorption, loss of alveolar bone, white spots on enamel due to demineralization around brackets and gingivitis.
- osteoperforation treatment reduced the patient's length of treatment from about 24 months to 11 months.
- osteoperforation was performed in the area of the missing laterals by four perforations in each side having 4-6 mm depth and 1.5 width using a hand instrument. The total procedure took less than 5 minutes without any flap or excessive bleeding. No analgesic or extra care other than mouth wash was prescribed, and close follow up of patient during the next few months did not reveal any discomfort or side effects. Protraction of the posterior teeth was accomplished using conventional mechanics. The treatment was accomplished in 13 months. This osteoperforation procedure reduced the patient treatment time from about 24 months to 13 months.
- a 45 year old Hispanic female was referred by another orthodontist due to the severity of the case and failure of previous orthodontic treatment.
- the patient had a very severe deep bite that was impinging on the lower gingiva, very dense bone around the upper anterior teeth and retroclined upper teeth.
- the previous orthodontist tried to correct the deep bite for 3 years with no success.
- After evaluation of bone density around the upper anterior teeth we decided to induce temporary osteopenia by osteoperforation and combine that with intrusion and retraction forces on the upper anterior teeth.
- the patient received ostoeperforation between the upper anterior teeth, 3 in each space between the anterior teeth, and each being 4-6 mm deep and 1.4 mm wide. The total procedure took less than 5 minutes without any flap or excessive bleeding.
Abstract
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Claims
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CN201080045963.3A CN102711654B (en) | 2009-08-11 | 2010-08-11 | The device of orthodontics |
CA2770642A CA2770642C (en) | 2009-08-11 | 2010-08-11 | Orthodontic methods and devices |
EP10808447.6A EP2464305A4 (en) | 2009-08-11 | 2010-08-11 | Orthodontic methods and devices |
AU2010282955A AU2010282955B2 (en) | 2009-08-11 | 2010-08-11 | Orthodontic methods and devices |
IL217998A IL217998A (en) | 2009-08-11 | 2012-02-08 | Method of moving a tooth to a desired position, a hand held perforating device for drilling minute perforations and a kit for providing the components for carrying out osteoperforation |
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US27390009P | 2009-08-11 | 2009-08-11 | |
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EP (1) | EP2464305A4 (en) |
CN (1) | CN102711654B (en) |
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Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2339983B1 (en) * | 2008-09-09 | 2014-11-26 | New York University | Devices to increase craniofacial bone density |
US8765031B2 (en) | 2009-08-13 | 2014-07-01 | Align Technology, Inc. | Method of forming a dental appliance |
US8896592B2 (en) | 2009-08-21 | 2014-11-25 | Align Technology, Inc. | Digital dental modeling |
US9241774B2 (en) | 2010-04-30 | 2016-01-26 | Align Technology, Inc. | Patterned dental positioning appliance |
US9211166B2 (en) | 2010-04-30 | 2015-12-15 | Align Technology, Inc. | Individualized orthodontic treatment index |
CA2835838C (en) * | 2011-05-13 | 2020-03-10 | Propel Orthodontics, Llc | Method and device for causing tooth movement |
ES2399890B2 (en) * | 2011-09-20 | 2013-11-04 | Universidad De Sevilla | FIXED ORTHODONTIC TRACTION EQUIPMENT FOR ANIMAL EXPERIMENTATION |
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US9433476B2 (en) | 2012-03-01 | 2016-09-06 | Align Technology, Inc. | Interproximal reduction planning |
US10085822B2 (en) | 2012-04-13 | 2018-10-02 | Advanced Orthodontics And Education Association, Llc | Method and device for increasing bone density in the mouth |
US9687323B2 (en) | 2012-06-07 | 2017-06-27 | Propel Orthodontics, Llc | Temporary anchorage device with external plate |
US9675427B2 (en) | 2013-06-07 | 2017-06-13 | Align Technology, Inc. | Adjusting a tooth position |
US9333053B2 (en) | 2013-08-07 | 2016-05-10 | Bandar ALYAMI | Orthodontic device |
USD761963S1 (en) | 2014-07-29 | 2016-07-19 | Propel Orthodontics, Llc | Microperforation dental device |
US10449016B2 (en) | 2014-09-19 | 2019-10-22 | Align Technology, Inc. | Arch adjustment appliance |
US9610141B2 (en) | 2014-09-19 | 2017-04-04 | Align Technology, Inc. | Arch expanding appliance |
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US11554000B2 (en) | 2015-11-12 | 2023-01-17 | Align Technology, Inc. | Dental attachment formation structure |
KR101725675B1 (en) * | 2015-11-12 | 2017-04-11 | 김재훈 | a dental drill for orthodontic treatment |
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US10383705B2 (en) | 2016-06-17 | 2019-08-20 | Align Technology, Inc. | Orthodontic appliance performance monitor |
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WO2019118876A1 (en) | 2017-12-15 | 2019-06-20 | Align Technology, Inc. | Closed loop adaptive orthodontic treatment methods and apparatuses |
US10980613B2 (en) | 2017-12-29 | 2021-04-20 | Align Technology, Inc. | Augmented reality enhancements for dental practitioners |
KR20200115580A (en) | 2018-01-26 | 2020-10-07 | 얼라인 테크널러지, 인크. | Oral diagnostic scan and tracking |
US11937991B2 (en) | 2018-03-27 | 2024-03-26 | Align Technology, Inc. | Dental attachment placement structure |
JP7374121B2 (en) | 2018-04-11 | 2023-11-06 | アライン テクノロジー, インコーポレイテッド | releasable palatal expander |
US20200202521A1 (en) | 2018-12-21 | 2020-06-25 | The Procter & Gamble Company | Apparatus and method for operating a personal grooming appliance or household cleaning appliance |
US11173014B2 (en) * | 2019-06-07 | 2021-11-16 | Elliot Davis | Minimally invasive method to enhance tooth movement velocity |
US11793452B2 (en) | 2019-10-03 | 2023-10-24 | Johnson & Johnson Consumer Inc. | Method of visualizing and quantifying remineralization |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4828113A (en) * | 1988-05-18 | 1989-05-09 | Friedland Jeffrey B | Dental treatment kit |
US5547657A (en) * | 1994-10-11 | 1996-08-20 | Eastman Chemical Company | Low-irritation anesthetic and antiseptic mouth rinse |
US20060116561A1 (en) * | 2004-11-30 | 2006-06-01 | Tricca Robert E | Systems and methods for intra-oral diagnosis |
US20070298375A1 (en) * | 2006-06-16 | 2007-12-27 | Straumann Holding Ag | Drill stop sleeve for a dental drill, dental drill device with a drill stop sleeve, and set containing several drill stop sleeves |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1328459A (en) | 1918-10-18 | 1920-01-20 | Arthur E Smith | Instrument for producing intra-osseous anesthesia |
DE2712696C3 (en) * | 1977-03-23 | 1984-06-20 | Dentaurum Hans-Peter Winkelstroeter Kg, 7536 Ispringen | Jaw expansion screw |
US4433956A (en) * | 1981-07-27 | 1984-02-28 | Witzig John W | Orthopedic corrector and method of correction of Class II malocclusion |
DE3301753C2 (en) * | 1982-04-08 | 1985-01-31 | Bernhard Förster GmbH, 7530 Pforzheim | Expansion screw for tooth regulation |
DE3220240A1 (en) * | 1982-05-07 | 1983-12-01 | Winfried Dr. 8000 München Schütz | DEVICE FOR ORTHODAEDIC DENTAL REGULATION |
US4747824A (en) * | 1986-05-30 | 1988-05-31 | Spinello Ronald P | Hypodermic anesthetic injection method |
US4944677A (en) * | 1987-06-29 | 1990-07-31 | Raymond Joseph Alexandre | Intraosseus dental anesthesia apparatus and method |
US5002485A (en) * | 1989-10-02 | 1991-03-26 | Aagesen Larry K | Orthopedic appliance |
US5154611A (en) * | 1990-10-09 | 1992-10-13 | Calvin Chen C | Endodontic instrument |
CN2097620U (en) * | 1991-07-11 | 1992-03-04 | 四川大学 | Surgical drill for artificial embedding tooth |
DE4125853A1 (en) * | 1991-08-03 | 1993-02-04 | Winkelstroeter Dentaurum | ELASTIC ADJUSTMENT SCREW |
US5281133A (en) * | 1992-11-16 | 1994-01-25 | Ormco Corporation | Rapid palatal expansion device |
US5439377A (en) * | 1994-04-21 | 1995-08-08 | Milanovich; Philip J. | Bi-directional orthodontic appliance |
US6109916A (en) * | 1997-10-03 | 2000-08-29 | Wilcko; M. Thomas | Orthodontic method and device |
CA2231116A1 (en) * | 1998-02-25 | 1999-08-25 | David E. Gibbs | Drilling catheter assembly |
US6412639B1 (en) * | 2000-04-28 | 2002-07-02 | Closure Medical Corporation | Medical procedure kit having medical adhesive |
US6827574B2 (en) * | 2001-04-12 | 2004-12-07 | Kevin L. Payton | Skeletal transmucosal orthodontic plate and method |
US9072543B2 (en) | 2002-05-31 | 2015-07-07 | Vidacare LLC | Vascular access kits and methods |
KR100539414B1 (en) * | 2004-02-17 | 2005-12-27 | (주) 코웰메디 | Dental drill set |
US7925329B2 (en) * | 2004-10-08 | 2011-04-12 | Proteus Biomedical, Inc. | Implantable doppler tomography system |
US7329122B1 (en) * | 2004-11-30 | 2008-02-12 | Michael Glenn Scott | Accelerated orthodontic apparatus and method |
KR100660374B1 (en) * | 2006-02-17 | 2006-12-22 | 송영완 | An implant drill |
-
2010
- 2010-08-11 EP EP10808447.6A patent/EP2464305A4/en not_active Withdrawn
- 2010-08-11 WO PCT/US2010/002202 patent/WO2011019382A1/en active Application Filing
- 2010-08-11 US US12/806,376 patent/US9271808B2/en active Active
- 2010-08-11 AU AU2010282955A patent/AU2010282955B2/en active Active
- 2010-08-11 CN CN201080045963.3A patent/CN102711654B/en active Active
- 2010-08-11 CA CA2770642A patent/CA2770642C/en active Active
-
2012
- 2012-02-08 IL IL217998A patent/IL217998A/en active IP Right Revival
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4828113A (en) * | 1988-05-18 | 1989-05-09 | Friedland Jeffrey B | Dental treatment kit |
US5547657A (en) * | 1994-10-11 | 1996-08-20 | Eastman Chemical Company | Low-irritation anesthetic and antiseptic mouth rinse |
US20060116561A1 (en) * | 2004-11-30 | 2006-06-01 | Tricca Robert E | Systems and methods for intra-oral diagnosis |
US20070298375A1 (en) * | 2006-06-16 | 2007-12-27 | Straumann Holding Ag | Drill stop sleeve for a dental drill, dental drill device with a drill stop sleeve, and set containing several drill stop sleeves |
Non-Patent Citations (16)
Title |
---|
ARIAS ET AL., AM J ORTHOD DENTOFACIAL ORTHOP, vol. 130, no. 3, 2006, pages 364 - 70 |
BASARAN ET AL., AM J ORTHOD DENTOFACIAL ORTHOP, vol. 130, 2006, pages EL-6 |
DAVIDOVITCH ET AL., DENT CLIN NORTH AM, vol. 32, no. 3, 1988, pages 411 - 35 |
FROST, CLIN ORTHOP RELAT RES, vol. 248, 1989, pages 283 - 93 |
FROST, CLIN ORTHOP RELAT RES, vol. 248, 1989, pages 294 - 309 |
FROST, HENRY FORD HOSP MED J, vol. 31, no. 1, 1983, pages 3 - 9 |
GARLET ET AL., EUR J ORAL SCI, vol. 115, no. 5, 2007, pages 355 - 62 |
GLANTSCHNIG ET AL., CELL DEATH DIFFER, vol. 10, no. 10, 2003, pages 1165 - 77 |
IINO ET AL.: "Acceleration of orthodontic tooth movement by alveolar corticotomy in the dog", AMERICAN JOURNAL OF OTHORDONTICS AND DENTOFACIAL ORTHOPEDICS, vol. 131, no. 4, April 2000 (2000-04-01), pages 448.E1 - 448.E8, XP022019590 * |
See also references of EP2464305A4 |
SEIDENBERG ET AL., PHARMACOL RES, vol. 50, no. 2, 2004, pages 151 - 6 |
SHIH ET AL., BONE, vol. 6, no. 5, 1985, pages 377 - 9 |
UEMATSU, J DENT RES., vol. 75, 1996, pages 562 - 567 |
YAFFE ET AL., JPERIODONTOL, vol. 65, no. 1, 1994, pages 79 - 83 |
YAO ET AL., JBIOL CHEM, vol. 283, no. 15, 2008, pages 9917 - 24 |
YOSHIMATSU, EJ BONE MINER METAB, vol. 24, no. 1, 2006, pages 20 - 7 |
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CA2770642C (en) | 2019-04-02 |
IL217998A0 (en) | 2012-03-29 |
EP2464305A4 (en) | 2015-01-07 |
CA2770642A1 (en) | 2011-02-17 |
IL217998A (en) | 2015-03-31 |
EP2464305A1 (en) | 2012-06-20 |
US9271808B2 (en) | 2016-03-01 |
AU2010282955A1 (en) | 2012-03-08 |
AU2010282955B2 (en) | 2015-06-18 |
US20110065060A1 (en) | 2011-03-17 |
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CN102711654A (en) | 2012-10-03 |
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