WO2001097902B1 - Medical imaging, diagnosis, and therapy using a scanning single optical fiber system - Google Patents

Medical imaging, diagnosis, and therapy using a scanning single optical fiber system

Info

Publication number
WO2001097902B1
WO2001097902B1 PCT/US2001/016844 US0116844W WO0197902B1 WO 2001097902 B1 WO2001097902 B1 WO 2001097902B1 US 0116844 W US0116844 W US 0116844W WO 0197902 B1 WO0197902 B1 WO 0197902B1
Authority
WO
WIPO (PCT)
Prior art keywords
interest
region
light guide
light
distal end
Prior art date
Application number
PCT/US2001/016844
Other languages
French (fr)
Other versions
WO2001097902A9 (en
WO2001097902A2 (en
WO2001097902A3 (en
Inventor
Eric Seibel
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Priority to AU2001274933A priority Critical patent/AU2001274933A1/en
Priority to JP2002503383A priority patent/JP5025877B2/en
Publication of WO2001097902A2 publication Critical patent/WO2001097902A2/en
Publication of WO2001097902A3 publication Critical patent/WO2001097902A3/en
Publication of WO2001097902B1 publication Critical patent/WO2001097902B1/en
Publication of WO2001097902A9 publication Critical patent/WO2001097902A9/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/262—Optical details of coupling light into, or out of, or between fibre ends, e.g. special fibre end shapes or associated optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/00043—Operational features of endoscopes provided with output arrangements
    • A61B1/00045—Display arrangement
    • A61B1/00048—Constructional features of the display
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
    • A61B1/00167—Details of optical fibre bundles, e.g. shape or fibre distribution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B1/00163—Optical arrangements
    • A61B1/00172—Optical arrangements with means for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00174—Optical arrangements characterised by the viewing angles
    • A61B1/00183—Optical arrangements characterised by the viewing angles for variable viewing angles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B1/005—Flexible endoscopes
    • A61B1/0051—Flexible endoscopes with controlled bending of insertion part
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    • A61B1/005—Flexible endoscopes
    • A61B1/009—Flexible endoscopes with bending or curvature detection of the insertion part
    • A—HUMAN NECESSITIES
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    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0655—Control therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
    • A—HUMAN NECESSITIES
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    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
    • G02B26/10—Scanning systems
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/241—Light guide terminations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00193—Optical arrangements adapted for stereoscopic vision
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1076—Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions inside body cavities, e.g. using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/32—Optical coupling means having lens focusing means positioned between opposed fibre ends
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/35—Optical coupling means having switching means
    • G02B6/3502—Optical coupling means having switching means involving direct waveguide displacement, e.g. cantilever type waveguide displacement involving waveguide bending, or displacing an interposed waveguide between stationary waveguides
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/35—Optical coupling means having switching means
    • G02B6/3564—Mechanical details of the actuation mechanism associated with the moving element or mounting mechanism details
    • G02B6/3566—Mechanical details of the actuation mechanism associated with the moving element or mounting mechanism details involving bending a beam, e.g. with cantilever
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/35—Optical coupling means having switching means
    • G02B6/3564—Mechanical details of the actuation mechanism associated with the moving element or mounting mechanism details
    • G02B6/3568—Mechanical details of the actuation mechanism associated with the moving element or mounting mechanism details characterised by the actuating force
    • G02B6/357—Electrostatic force
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/35—Optical coupling means having switching means
    • G02B6/3564—Mechanical details of the actuation mechanism associated with the moving element or mounting mechanism details
    • G02B6/3568—Mechanical details of the actuation mechanism associated with the moving element or mounting mechanism details characterised by the actuating force
    • G02B6/3572—Magnetic force
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/35—Optical coupling means having switching means
    • G02B6/3564—Mechanical details of the actuation mechanism associated with the moving element or mounting mechanism details
    • G02B6/3568—Mechanical details of the actuation mechanism associated with the moving element or mounting mechanism details characterised by the actuating force
    • G02B6/3578—Piezoelectric force

Abstract

An integrated endoscopic image acquisition and therapeutic delivery system (50) for use in minimally invasive medical procedures (MIMPs). The system uses directed and scanned optical illumination provided by a scanning optical electromechnical actuator included at a distal end of an integrated imaging and diagnostic/therapeuric instrument. The directed illumination provides high resolution imaging, at a wide field of view (FOV), and in full color that matches or excels the images produced by conventional flexible endoscopes. When using scanned optical illumination, the size and number of the photon detectors do not limit the resolution and number of pixels of the resulting image. Additional features include enhancement of topographical features, stereoscopic viewing, and accurate measurement of feature sizes of a region of interest in a patient's body that facilitate providing diagnosis, monitoring, and/or therapy with the instrument.

Claims

AMENDED CLAIMS
[received by the International Bureau on 30 April 2002 (30.04.02); original claims 7, 28 and 62 amended; remaining claims unchanged (4 pages)]
5. The apparatus of Claim 4, further comprising a plurality of light guides that convey the light reflected from a region of interest to the plurality of light sensors.
6. The apparatus of Claim 5, wherein different portions of the plurality of light guides are adapted to convey light collected from spaced-apart areas within a region of interest, enabling a pseudo-stereo image of a region of interest to be visualized by a user with the display.
7. The apparatus of Claim 1, wherein the light detector comprises a plurality of light sensors that are coupled to the distal end of the light guide.
8. The apparatus of Claim 1, wherein the scanning actuator comprises at least one electromechanical actuator that moves the distal end of the light guide in a two-dimensional scanning mode.
9. The apparatus of Claim 1, wherein the scanning actuator comprises a piezoceramic actuator that is energized at a harmonic of a resonant frequency of the distal end of the light guide, causing the light guide to oscillate.
10. The apparatus of Claim 1, wherein the light guide comprises an optical fiber, and wherein the distal end of the optical fiber is tapered to a substantially smaller cross-sectional size than a more proximal portion of the optical fiber.
11. The apparatus of Claim 1, further comprising at least one lens adapted to be disposed between the distal end of the light guide and a region of interest, said at least one lens being adapted to focus the light produced by the at least one light source onto a region of interest.
12. The apparatus of Claim 11, wherein said at least one lens comprises a lens mounted at the distal end of the light guide, said scanning actuator being adapted to drive the distal end of the light guide in a resonance mode to scan a region of interest, said lens that is mounted at the distal end of the light guide having sufficient mass so that the lens generally rotates as the light guide moves to change a direction in which light is emitted, when scanning a region of interest.
13. The apparatus of Claim 1, wherein the light guide comprises a first thin film optical waveguide disposed at the distal end of the light guide so that the
39
23. The apparatus of Claim 1, further comprising a thermal detector coupled to one of the proximal and distal ends of the light guide for use in monitoring a temperature in a region of interest.
24. The apparatus of Claim 1, wherein the display comprises a stereo display that enables a user to visualize a pseudo-stereo image of a region of interest.
25. The apparatus of Claim 1, further comprising means for guiding and maneuvering the distal end of the light guide to a region of interest within a patient.
26. The apparatus of Claim 1, further comprising a balloon disposed adjacent to the distal end of the light guide, said balloon being adapted to stabilize the distal end of the light guide in a cavity within a patient when the balloon is inflated.
27. The apparatus of Claim 1, further comprising electrical leads that extend along the light guide, to its distal end, said electrical leads being connected to the scanning actuator to energize it.
28. A method for using an integral light guide system to selectively image and carry out at least one other substantive function in connection with a region of interest in a patient, said method comprising the steps of:
(a) directing a light at the region of interest in the patient through a light guide;
(b) scanning the region of interest with the light by moving the light guide with a scanning actuator;
(c) detecting light from the region of interest and in response thereto, producing signals indicative of characteristics of said light, including an intensity of the light received from the region of interest;
(d) imaging the region of interest, using the signals produced by the step of detecting; and
(e) controlling the administration of the light to the region of interest through the light guide, to selectively carry out at least one of the steps of:
(i) monitoring the region of interest; (ii) determining a biophysical condition of the region of interest; and
41 (iii) rendering therapy to the region of interest with the light directed thereon.
29. The method of Claim 28, further comprising the step of receiving light from the region of interest at a plurality of spaced-apart locations, said step of imaging comprising the step of enabling a user to visually perceive a pseudo-stereo image of the region of interest.
30. The method of Claim 28, wherein the step of scanning comprises the step of causing the light guide to move so that the light emitted from the light guide scans over the region of interest in two generally orthogonal directions.
31. The method of Claim 28, wherein the step of scanning comprises the step of causing the light guide to move so that the light emitted from the light guide scans over the region of interest in a helical arc.
32. The method of Claim 28, wherein the step of scanning comprises the step of causing the light guide to move so that the light emitted from the light guide scans the region of interest in at least one of:
(a) generally concentric circles of different radii; and
(b) a propeller scan mode.
33. The method of Claim 28, further comprising the step of focusing the light onto the region of interest through a lens.
34. The method of Claim 33, further comprising the step of mounting the lens at a distal end of the light guide.
35. The method of Claim 34, wherein the lens is of sufficient mass that as the light guide moves, the lens is rotated about a center of the lens, but otherwise remains generally fixed.
36. The method of Claim 28, wherein a distal end of the light guide comprises a thin film optical waveguide, said step of scanning comprising the step of causing the thin film optical waveguide to move so that light emitted thereby is scanned over the region of interest.
37. The method of Claim 28, wherein the step of scanning comprises the step of driving a distal end of the light guide into a resonance movement mode.
42
61. The apparatus of Claim 52, further comprising a light detector adapted to receive light from the region of interest.
62. A method for automatically scanning a region of interest in a patient's body, comprising the steps of:
(a) conveying light from a source through a light guide having a distal end that is disposed adjacent to the region of interest;
(b) automatically moving the distal end of the light guide in a desired scanning pattern in response to a scanning signal; and
(c) scanning the region of interest with light directed at the region of interest through the distal end of the light, directing the light at the region of interest in said scanning pattern.
63. The method of Claim 62, wherein the step of scanning comprises the step of causing the distal end of the light guide to move so that the light emitted from the light guide scans over the region of interest in two generally orthogonal directions.
64. The method of Claim 62, wherein the step of scanning comprises the step of causing the light guide to move so that the light emitted from the light guide scans over the region of interest in a helical arc.
65. The method of Claim 62, wherein the step of scanning comprises the step of causing the light guide to move so that the light emitted from the light guide scans the region of interest in one of:
(a) generally concentric circles of different radii; and
(b) a propeller scan mode.
66. The method of Claim 62, further comprising the step of mounting the lens at a distal end of the light guide.
67. The method of Claim 66, wherein the lens is of sufficient mass that as the light guide moves, the lens is rotated.
68. The method of Claim 62, wherein a distal end of the light guide comprises a thin film optical waveguide, said step of scanning comprising the step of causing a distal end of the thin film optical waveguide to move so that light emitted thereby is scanned over the region of interest in the desired scanning pattern.
PCT/US2001/016844 2000-06-19 2001-05-23 Medical imaging, diagnosis, and therapy using a scanning single optical fiber system WO2001097902A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001274933A AU2001274933A1 (en) 2000-06-19 2001-05-23 Medical imaging, diagnosis, and therapy using a scanning single optical fiber system
JP2002503383A JP5025877B2 (en) 2000-06-19 2001-05-23 Medical imaging, diagnosis and treatment using a scanning single fiber optic system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21241100P 2000-06-19 2000-06-19
US60/212,411 2000-06-19

Publications (4)

Publication Number Publication Date
WO2001097902A2 WO2001097902A2 (en) 2001-12-27
WO2001097902A3 WO2001097902A3 (en) 2002-06-20
WO2001097902B1 true WO2001097902B1 (en) 2002-10-10
WO2001097902A9 WO2001097902A9 (en) 2004-11-18

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Family Applications (1)

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PCT/US2001/016844 WO2001097902A2 (en) 2000-06-19 2001-05-23 Medical imaging, diagnosis, and therapy using a scanning single optical fiber system

Country Status (4)

Country Link
US (1) US6975898B2 (en)
JP (1) JP5025877B2 (en)
AU (1) AU2001274933A1 (en)
WO (1) WO2001097902A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
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US6975898B2 (en) 2005-12-13
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