WO2000026935A8 - Systems and methods for high performance scanning - Google Patents

Systems and methods for high performance scanning

Info

Publication number
WO2000026935A8
WO2000026935A8 PCT/US1999/024049 US9924049W WO0026935A8 WO 2000026935 A8 WO2000026935 A8 WO 2000026935A8 US 9924049 W US9924049 W US 9924049W WO 0026935 A8 WO0026935 A8 WO 0026935A8
Authority
WO
WIPO (PCT)
Prior art keywords
scanning
objective lens
voice coil
inexpensive
rapid
Prior art date
Application number
PCT/US1999/024049
Other languages
French (fr)
Other versions
WO2000026935A2 (en
Inventor
David Stern
Original Assignee
Affymetrix Inc
David Stern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc, David Stern filed Critical Affymetrix Inc
Priority to AU12057/00A priority Critical patent/AU1205700A/en
Priority to JP2000580227A priority patent/JP2004507710A/en
Priority to EP99971578A priority patent/EP1269508A2/en
Publication of WO2000026935A2 publication Critical patent/WO2000026935A2/en
Publication of WO2000026935A8 publication Critical patent/WO2000026935A8/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008—Details of detection or image processing, including general computer control
    • G02B21/0084—Details of detection or image processing, including general computer control time-scale detection, e.g. strobed, ultra-fast, heterodyne detection
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/0048—Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008—Details of detection or image processing, including general computer control
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/26—Stages; Adjusting means therefor

Abstract

Cette invention se rapporte à un système de détection d'images à microscope confocal à balayage, comprenant une lentille objectif simple et peu coûteuse et un système de translation mû par bobine mobile à accélération élevée/haute vitesse. La lentille objectif fournit une efficacité élevée de captage de la lumière à faible coût. La bobine mobile assure une accélération accrue pour le balayage rapide d'au moins un axe (direction de balayage, axe de balayage rapide) d'une matrice polymère, qui peut être utilisé efficacement avec la lentille objectif peu coûteuse ayant une efficacité élevée de captage de la lumière. Dans un mode de réalisation, l'étage de translation comprend une bobine mobile, un coulisseau linéaire et un étrier léger reliant la bobine mobile au coulisseau linéaire. Cet étrier est rigide et il est conçu pour soutenir une matrice polymère devant être balayée ou un prisme de rotation et la lentille objectif. Ainsi, cette invention fournit des systèmes et des procédés pour le balayage rapide et peu coûteux notamment de matrices polymères, c'est-à-dire le balayage hautes performances et rentable de matrices polymères à l'aide d'un étage de translation mû par bobine mobile.This invention relates to a system for detecting images with a scanning confocal microscope, comprising a simple and inexpensive objective lens and a translation system driven by a moving coil with high acceleration / high speed. The objective lens provides high light capture efficiency at low cost. The voice coil provides increased acceleration for rapid scanning of at least one axis (scanning direction, rapid scanning axis) of a polymer matrix, which can be used effectively with the inexpensive objective lens having a high capture efficiency light. In one embodiment, the translation stage comprises a voice coil, a linear slide and a light bracket connecting the voice coil to the linear slide. This bracket is rigid and is designed to support a polymer matrix to be scanned or a rotational prism and the objective lens. Thus, this invention provides systems and methods for rapid and inexpensive scanning in particular of polymer matrices, that is to say the high performance and cost-effective scanning of polymer matrices using a translation stage driven by voice coil.

PCT/US1999/024049 1998-10-30 1999-10-27 Systems and methods for high performance scanning WO2000026935A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU12057/00A AU1205700A (en) 1998-10-30 1999-10-27 Systems and methods for high performance scanning
JP2000580227A JP2004507710A (en) 1998-10-30 1999-10-27 System and method for performing high performance scanning
EP99971578A EP1269508A2 (en) 1998-10-30 1999-10-27 Systems and methods for high performance scanning

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10639798P 1998-10-30 1998-10-30
US60/106,397 1998-10-30
US09/383,986 US6545264B1 (en) 1998-10-30 1999-08-26 Systems and methods for high performance scanning
US09/383,986 1999-08-26

Publications (2)

Publication Number Publication Date
WO2000026935A2 WO2000026935A2 (en) 2000-05-11
WO2000026935A8 true WO2000026935A8 (en) 2001-12-27

Family

ID=26803624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024049 WO2000026935A2 (en) 1998-10-30 1999-10-27 Systems and methods for high performance scanning

Country Status (5)

Country Link
US (1) US6545264B1 (en)
EP (1) EP1269508A2 (en)
JP (1) JP2004507710A (en)
AU (1) AU1205700A (en)
WO (1) WO2000026935A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9540689B2 (en) 1998-05-01 2017-01-10 Life Technologies Corporation Method of determining the nucleotide sequence of oligonucleotides and DNA molecules

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH697814B1 (en) * 2001-01-26 2009-02-27 Tecan Trading Ag Optical system and method for exciting and measuring fluorescence on or in samples treated with fluorescent dyes.
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
AU773664B2 (en) * 1998-10-30 2004-06-03 Affymetrix, Inc. Systems and methods for high performance scanning
US6371370B2 (en) * 1999-05-24 2002-04-16 Agilent Technologies, Inc. Apparatus and method for scanning a surface
JP2003507777A (en) * 1999-08-26 2003-02-25 アフィメトリックス インコーポレイテッド Apparatus and method for performing high performance scanning
US20020180159A1 (en) * 2000-12-13 2002-12-05 Nsk Ltd. Sealing device and positioning device using the same
WO2003019161A1 (en) * 2001-08-23 2003-03-06 D.N.R. - Imaging Systems Ltd. Optical system and method for inspecting fluorescently labeled biological specimens
ITMI20010566U1 (en) * 2001-10-25 2003-04-25 Troletti Adriano HAIR DRYER, WITH HIGH PRACTICALITY OF USE
JP3678192B2 (en) * 2001-11-21 2005-08-03 横河電機株式会社 Measuring device
US6791690B2 (en) * 2002-04-30 2004-09-14 Agilent Technologies, Inc. Reading dry chemical arrays
US20040090127A1 (en) * 2002-11-12 2004-05-13 Toshiba Tec Kabushiki Kaisha Motor controller for image reading apparatus, and image reading apparatus with the same
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
US7030383B2 (en) * 2003-08-04 2006-04-18 Cadent Ltd. Speckle reduction method and apparatus
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
EP2248911A1 (en) 2004-02-19 2010-11-10 Helicos Biosciences Corporation Methods and kits for analyzing polynucleotide sequences
US7093939B2 (en) * 2004-04-05 2006-08-22 Nextscan, Inc. High-speed continuous linear film transport system
US7768638B2 (en) * 2005-03-18 2010-08-03 Illumina, Inc. Systems for and methods of facilitating focusing an optical scanner
US8351026B2 (en) 2005-04-22 2013-01-08 Affymetrix, Inc. Methods and devices for reading microarrays
US20070023521A1 (en) * 2005-07-29 2007-02-01 Chester Wildey Apparatus and method for security tag detection
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US7279814B2 (en) * 2005-11-01 2007-10-09 Bio-Rad Laboratories, Inc. Moving coil actuator for reciprocating motion with controlled force distribution
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US7791013B2 (en) * 2006-11-21 2010-09-07 Illumina, Inc. Biological microarray line scanning method and system
US7813013B2 (en) * 2006-11-21 2010-10-12 Illumina, Inc. Hexagonal site line scanning method and system
US20140142404A1 (en) * 2008-10-23 2014-05-22 The Washington University Single-cell label-free photoacoustic flowoxigraphy in vivo
US8454512B2 (en) * 2007-10-25 2013-06-04 Washington University Confocal photoacoustic microscopy with optical lateral resolution
WO2010048258A1 (en) 2008-10-23 2010-04-29 Washington University In St. Louis Reflection-mode photoacoustic tomography using a flexibly-supported cantilever beam
ES2396607T3 (en) * 2007-12-27 2013-02-22 Cytyc Corporation System to control a cytological specimen in a controllable way
US20090203022A1 (en) * 2008-02-07 2009-08-13 Arizona Board Of Regents For And On Behalf Of Arizona State University Analysis
DE102008015049B4 (en) * 2008-03-19 2014-11-06 Schneider Gmbh & Co. Kg Linear drive for a machine tool
US8725477B2 (en) 2008-04-10 2014-05-13 Schlumberger Technology Corporation Method to generate numerical pseudocores using borehole images, digital rock samples, and multi-point statistics
US9581723B2 (en) 2008-04-10 2017-02-28 Schlumberger Technology Corporation Method for characterizing a geological formation traversed by a borehole
EP2393941A2 (en) * 2009-02-09 2011-12-14 Frederic Zenhausern Improvements in and relating to microfluidic devices for processing a sample
US20110004447A1 (en) * 2009-07-01 2011-01-06 Schlumberger Technology Corporation Method to build 3D digital models of porous media using transmitted laser scanning confocal mircoscopy and multi-point statistics
US8311788B2 (en) * 2009-07-01 2012-11-13 Schlumberger Technology Corporation Method to quantify discrete pore shapes, volumes, and surface areas using confocal profilometry
US8997572B2 (en) 2011-02-11 2015-04-07 Washington University Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
US11020006B2 (en) 2012-10-18 2021-06-01 California Institute Of Technology Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data
WO2015077355A1 (en) 2013-11-19 2015-05-28 Washington University Systems and methods of grueneisen-relaxation photoacoustic microscopy and photoacoustic wavefront shaping
RU2016127260A (en) * 2013-12-31 2018-02-06 Мемориал Слоун Кеттеринг Кэнсэ Сентр SYSTEMS, METHODS AND DEVICE FOR MULTI-CHANNEL DISPLAY OF FLUORESCENT SOURCES IN REAL TIME
WO2018209046A1 (en) 2017-05-10 2018-11-15 Washington University Snapshot photoacoustic photography using an ergodic relay
WO2020037082A1 (en) 2018-08-14 2020-02-20 California Institute Of Technology Multifocal photoacoustic microscopy through an ergodic relay
US11592652B2 (en) 2018-09-04 2023-02-28 California Institute Of Technology Enhanced-resolution infrared photoacoustic microscopy and spectroscopy
US11369280B2 (en) 2019-03-01 2022-06-28 California Institute Of Technology Velocity-matched ultrasonic tagging in photoacoustic flowgraphy
US20220299536A1 (en) * 2019-05-01 2022-09-22 Rohit Hiwale Automated positioning and imaging of samples
CN114199768A (en) * 2021-12-10 2022-03-18 济南国科医工科技发展有限公司 Line scanning confocal reflective imaging device

Family Cites Families (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013467A (en) 1957-11-07 1961-12-19 Minsky Marvin Microscopy apparatus
US3862056A (en) 1967-12-15 1975-01-21 Allied Chem Semiconductor polymer compositions comprising a grafted block copolymer of synthetic rubber and polyolefin and carbon black
DE2150691C2 (en) 1971-10-12 1982-09-09 Basf Ag, 6700 Ludwigshafen Photosensitive mixture and use of a photosensitive mixture for the production of a planographic printing plate
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
SE407115B (en) 1975-10-06 1979-03-12 Kabi Ab PROCEDURES AND METAL ELECTRODES FOR THE STUDY OF ENZYMATIC AND OTHER BIOCHEMICAL REACTIONS
US4238757A (en) 1976-03-19 1980-12-09 General Electric Company Field effect transistor for detection of biological reactions
US4180739A (en) 1977-12-23 1979-12-25 Varian Associates, Inc. Thermostatable flow cell for fluorescence measurements
US4448534A (en) 1978-03-30 1984-05-15 American Hospital Corporation Antibiotic susceptibility testing
US4269933A (en) 1978-06-08 1981-05-26 E. I. Du Pont De Nemours And Company Methods of developing photopolymerizable compositions containing an 0-nitroaromatic compound as photoinhibitor
US4314821A (en) 1979-04-09 1982-02-09 Minnesota Mining And Manufacturing Company Sandwich immunoassay using piezoelectric oscillator
US4342905A (en) 1979-08-31 1982-08-03 Nippon Kogaku K.K. Automatic focusing device of a microscope
US4500707A (en) 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4327073A (en) 1980-04-07 1982-04-27 Huang Henry V Automated method for quantitative analysis of biological fluids
US4444892A (en) 1980-10-20 1984-04-24 Malmros Mark K Analytical device having semiconductive organic polymeric element associated with analyte-binding substance
IL61351A (en) 1980-10-27 1983-12-30 Yeda Res & Dev Organometallic polymers,their preparation and compositions of co-ordination compounds containing them
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
FI76888C (en) 1981-04-29 1988-12-12 Ciba Geigy Ag New agents and packaging for immunological analysis.
US4373071A (en) 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4339528A (en) 1981-05-19 1982-07-13 Rca Corporation Etching method using a hardened PVA stencil
US4444878A (en) 1981-12-21 1984-04-24 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
US4483920A (en) 1982-05-17 1984-11-20 Hahnemann University Immobilization of message RNA directly from cells onto filter material
US4624915A (en) 1982-07-29 1986-11-25 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4973493A (en) 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US4722906A (en) 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US4516833A (en) 1982-12-27 1985-05-14 University Of Dayton Production of high performance optical spatial filters
DE3301833A1 (en) 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig METHOD FOR SIMULTANEOUS SYNTHESIS OF SEVERAL OLIGONOCLEOTIDES IN A SOLID PHASE
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4537861A (en) 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
US4584277A (en) 1983-04-05 1986-04-22 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4517338A (en) 1983-06-20 1985-05-14 Chiron Corporation Multiple reactor system and method for polynucleotide synthesis
US4542102A (en) 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4713326A (en) 1983-07-05 1987-12-15 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4987065A (en) 1983-07-05 1991-01-22 Enzo Biochem, Inc. In vivo labelling of polynucleotide sequences
US4626684A (en) 1983-07-13 1986-12-02 Landa Isaac J Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
US4677054A (en) 1983-08-08 1987-06-30 Sloan-Kettering Institute For Cancer Research Method for simple analysis of relative nucleic acid levels in multiple small samples by cytoplasmic dot hybridization
US4719615A (en) 1983-08-22 1988-01-12 Optical Data, Inc. Erasable optical data storage medium
US4569967A (en) 1983-10-24 1986-02-11 The Salk Institute For Biological Studies Synthesis of N-substituted peptide amides
US4580895A (en) 1983-10-28 1986-04-08 Dynatech Laboratories, Incorporated Sample-scanning photometer
US4849513A (en) 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US4613566A (en) 1984-01-23 1986-09-23 President And Fellows Of Harvard College Hybridization assay and kit therefor
FI71768C (en) 1984-02-17 1987-02-09 Orion Yhtymae Oy Enhanced nucleic acid reagents and process for their preparation.
US4704353A (en) 1984-04-27 1987-11-03 Molecular Devices Corporation Photoresponsive redox detection and discrimination
DE3565986D1 (en) 1984-05-02 1988-12-08 Brendan James Hamill An apparatus for the chemical synthesis of oligonucleotides
US4555490A (en) 1984-06-08 1985-11-26 The United States Of America As Represented By The Department Of Health And Human Services Rapid visualization system for gel electrophoresis
US4755458A (en) 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US4681859A (en) 1984-09-21 1987-07-21 Ortho Diagnostic Systems Inc. Fluorescence polarization immunoassay for heavy antigens
US5258506A (en) 1984-10-16 1993-11-02 Chiron Corporation Photolabile reagents for incorporation into oligonucleotide chains
US4820630A (en) 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
US5026840A (en) 1985-01-10 1991-06-25 Molecular Diagnostics, Inc. Photochemical nucleic acid-labeling reagent having a polyalklamine spacer
US4713347A (en) 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE3513168A1 (en) 1985-04-12 1986-10-16 Thomas 8000 München Dandekar BIOSENSOR CONSISTING OF A SEMICONDUCTOR BASED ON SILICON OR CARBON-BASED (ELECTRONIC PART) AND NUCLEIN BASE (OR. OTHER BIOL. MONOMERS)
NZ215865A (en) 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
FR2583772B1 (en) 1985-06-20 1987-08-28 Roussel Uclaf NEW MEDIA, THE PREPARATION OF SUCH MEDIA, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION TO THE SYNTHESIS OF OLIGONUCLEOTIDES AND THE NEW NUCLEOSIDES AND OLIGONUCLEOTIDES RELATED TO THE MEDIA THUS OBTAINED
FR2584090B1 (en) 1985-06-27 1987-08-28 Roussel Uclaf NEW SUPPORTS, THEIR PREPARATION AND THE INTERMEDIATES OBTAINED, THEIR APPLICATION TO THE SYNTHESIS OF OLIGONUCLEOTIDES AND THE NEW NUCLEOSIDES AND OLIGONUCLEOTIDES RELATED TO THE SUPPORTS OBTAINED
EP0212807A3 (en) 1985-07-15 1988-01-07 Imperial Chemical Industries Plc Coloured compound containing a cationic group and a reactive group
DD254998A1 (en) 1985-07-26 1988-03-16 Zeiss Jena Veb Carl ARRANGEMENT FOR THE IMAGE AND ANALYSIS OF FLUORESCENCE SIGNALS
WO1987000926A1 (en) 1985-08-05 1987-02-12 Rijksuniversiteit Leiden Labelled macromolecules; a process for their preparation and their use for immunological or immunocytochemical assays
US4888278A (en) 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US4822566A (en) 1985-11-19 1989-04-18 The Johns Hopkins University Optimized capacitive sensor for chemical analysis and measurement
US4637861A (en) 1985-12-16 1987-01-20 Allied Corporation Stabilized, lipid membrane-based device and method of analysis
US5447841A (en) 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US4855225A (en) 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
JPH0685387B2 (en) 1986-02-14 1994-10-26 株式会社東芝 Alignment method
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5348855A (en) 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
US4925785A (en) 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
US4728591A (en) 1986-03-07 1988-03-01 Trustees Of Boston University Self-assembled nanometer lithographic masks and templates and method for parallel fabrication of nanometer scale multi-device structures
US5310893A (en) 1986-03-31 1994-05-10 Hoffmann-La Roche Inc. Method for HLA DP typing
US5256549A (en) 1986-03-28 1993-10-26 Chiron Corporation Purification of synthetic oligomers
US5153319A (en) 1986-03-31 1992-10-06 University Patents, Inc. Process for preparing polynucleotides
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US4846552A (en) 1986-04-16 1989-07-11 The United States Of America As Represented By The Secretary Of The Air Force Method of fabricating high efficiency binary planar optical elements
US4808508A (en) 1986-07-01 1989-02-28 Hoechst Celanese Corporation Negative working color proofing process comprising diazo compound and polyvinyl acetal/polyvinyl alcohol/polyvinyl acetate resin
US4786684A (en) 1986-08-21 1988-11-22 The Mount Sinai School Of Medicine Of The City University Of New York Benzylthioether-linked solid support-bound thiol compounds and method for peptide synthesis
US5021550A (en) 1986-10-07 1991-06-04 Thomas Jefferson University Method for preventing deletion sequences in solid phase synthesis
GB8624637D0 (en) 1986-10-14 1986-11-19 Emi Plc Thorn Electrical device
US4979959A (en) 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US5028525A (en) 1986-11-24 1991-07-02 Regents Of The University Of California Method of preparing and applying single stranded DNA probes to double stranded target DNAs in situ
JPS63167313A (en) 1986-12-27 1988-07-11 Hitachi Ltd Automatic focus control method
US4762881A (en) 1987-01-09 1988-08-09 E. I. Du Pont De Nemours And Company Photoreactive benzoylphenylalanines and related peptides
US5079600A (en) 1987-03-06 1992-01-07 Schnur Joel M High resolution patterning on solid substrates
US5026773A (en) 1987-03-11 1991-06-25 Samuel Steel Apparatus for a solid phase synthesis of peptide analogs
US4794150A (en) 1987-03-11 1988-12-27 Samuel Steel Synthesis of peptide analogs
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US4874500A (en) 1987-07-15 1989-10-17 Sri International Microelectrochemical sensor and sensor array
US4923901A (en) 1987-09-04 1990-05-08 Millipore Corporation Membranes with bound oligonucleotides and peptides
US4981985A (en) 1987-10-20 1991-01-01 Trustees Of The University Of Pennsylvania Synthesis of photolabile chelators for multivalent cations
US4886741A (en) 1987-12-09 1989-12-12 Microprobe Corporation Use of volume exclusion agents for the enhancement of in situ hybridization
US4844617A (en) 1988-01-20 1989-07-04 Tencor Instruments Confocal measuring microscope with automatic focusing
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
US4946942A (en) 1988-03-11 1990-08-07 Bioresearch, Inc. Urethane-protected amino acid-N-carboxyanhydrides
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5002867A (en) 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
DE3923165A1 (en) 1988-07-15 1990-01-18 Hitachi Ltd MAGNETIC DISK DEVICE
US4992383A (en) 1988-08-05 1991-02-12 Porton Instruments, Inc. Method for protein and peptide sequencing using derivatized glass supports
US5206137A (en) 1988-09-08 1993-04-27 Lifecodes Corporation Compositions and methods useful for genetic analysis
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5215889A (en) 1988-11-18 1993-06-01 The Regents Of The University Of California Catalytic and reactive polypeptides and methods for their preparation and use
US5489507A (en) 1988-11-30 1996-02-06 Perkin-Elmer Corporation DNA detection by color complementation
US5047524A (en) 1988-12-21 1991-09-10 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US5081584A (en) 1989-03-13 1992-01-14 United States Of America Computer-assisted design of anti-peptides based on the amino acid sequence of a target peptide
US5112962A (en) 1989-04-19 1992-05-12 Northwestern University Labile anchors for solid phase polynucleotide synthesis
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
DE3924454A1 (en) 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg THE APPLICATION OF DNA AND DNA TECHNOLOGY FOR THE CONSTRUCTION OF NETWORKS FOR USE IN CHIP CONSTRUCTION AND CHIP PRODUCTION (DNA CHIPS)
US5141813A (en) 1989-08-28 1992-08-25 Clontech Laboratories, Inc. Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
US5232829A (en) 1989-09-29 1993-08-03 Hoffmann-La Roche Inc. Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5215882A (en) 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
US5091652A (en) 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
GB9014263D0 (en) 1990-06-27 1990-08-15 Dixon Arthur E Apparatus and method for spatially- and spectrally- resolvedmeasurements
US5306641A (en) 1990-07-27 1994-04-26 Saccocio Edward J Apparatus and method for determining gel rate of polymerizable compositions
US5235028A (en) 1990-08-31 1993-08-10 University Of Minnesota Polyethylene glycol derivatives for solid-phase applications
US5260589A (en) 1990-11-02 1993-11-09 Norikatsu Yamauchi Semiconductor device having reflecting layers made of varying unit semiconductors
RU1794088C (en) 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Method of dna nucleotide sequence determination and a device for its realization
JPH0527177A (en) * 1991-07-25 1993-02-05 Fuji Photo Film Co Ltd Scanning type microscope
US5556961A (en) 1991-11-15 1996-09-17 Foote; Robert S. Nucleosides with 5'-O-photolabile protecting groups
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5667667A (en) 1992-04-24 1997-09-16 Isis Innovation Limited Electrochemical treatment of surfaces
EP1157743B1 (en) 1993-10-28 2009-03-11 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5459325A (en) 1994-07-19 1995-10-17 Molecular Dynamics, Inc. High-speed fluorescence scanner
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5707806A (en) 1995-06-07 1998-01-13 Genzyme Corporation Direct sequence identification of mutations by cleavage- and ligation-associated mutation-specific sequencing
US5777888A (en) 1995-08-09 1998-07-07 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US5698393A (en) 1995-08-18 1997-12-16 Abbott Laboratories Method for elimination of rheumatoid factor interference in diagnostic assays
US5871697A (en) 1995-10-24 1999-02-16 Curagen Corporation Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
JP2000512744A (en) * 1996-05-16 2000-09-26 アフィメトリックス，インコーポレイテッド System and method for detecting label material
US5880465A (en) * 1996-05-31 1999-03-09 Kovex Corporation Scanning confocal microscope with oscillating objective lens
US6193199B1 (en) * 1998-07-15 2001-02-27 Nanomotion, Inc. Sample stage including a slider assembly

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9540689B2 (en) 1998-05-01 2017-01-10 Life Technologies Corporation Method of determining the nucleotide sequence of oligonucleotides and DNA molecules

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EP1269508A2 (en) 2003-01-02
WO2000026935A2 (en) 2000-05-11

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