WO1997023208A1 - Taxane composition and method - Google Patents
Taxane composition and method Download PDFInfo
- Publication number
- WO1997023208A1 WO1997023208A1 PCT/US1996/020187 US9620187W WO9723208A1 WO 1997023208 A1 WO1997023208 A1 WO 1997023208A1 US 9620187 W US9620187 W US 9620187W WO 9723208 A1 WO9723208 A1 WO 9723208A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- solution
- taxane
- taxol
- storage solution
- castor oil
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96943805A EP0876145A4 (en) | 1995-12-21 | 1996-12-19 | Taxane composition and method |
AU12949/97A AU724842B2 (en) | 1995-12-21 | 1996-12-19 | Taxane composition and method |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57620495A | 1995-12-21 | 1995-12-21 | |
US08/576,204 | 1995-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997023208A1 true WO1997023208A1 (en) | 1997-07-03 |
Family
ID=24303400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/020187 WO1997023208A1 (en) | 1995-12-21 | 1996-12-19 | Taxane composition and method |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0876145A4 (en) |
KR (1) | KR970032859A (en) |
CN (1) | CN1209059A (en) |
AU (1) | AU724842B2 (en) |
CA (1) | CA2240595A1 (en) |
WO (1) | WO1997023208A1 (en) |
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000020036A1 (en) * | 1998-10-02 | 2000-04-13 | Abbott Laboratories | Pharmaceutical compositions containing paclitaxel |
WO2002043765A2 (en) * | 2000-11-28 | 2002-06-06 | Transform Pharmaceuticals, Inc. | Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof |
EP1221908A1 (en) * | 1995-10-26 | 2002-07-17 | Ivax Research, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
EP1479382A1 (en) * | 1999-06-18 | 2004-11-24 | IVAX Research, Inc. | Oral pharmaceutical compositions containing taxanes and methods for treatment employing the same |
WO2007020085A2 (en) * | 2005-08-19 | 2007-02-22 | Sandoz Ag | Compositions containing taxane derivatives for intravenous injection |
WO2007134354A1 (en) * | 2006-05-23 | 2007-11-29 | Ebewe Pharma Ges.M.B.H. Nfg. Kg | Pharmaceutical formulation |
WO2007124700A3 (en) * | 2006-05-03 | 2007-12-21 | I Q A A S | Pharmaceutical composition containing taxane derivative destined for the preparation of an infusion solution, method of preparation thereof and use thereof |
EP1904052A1 (en) * | 2005-06-17 | 2008-04-02 | Hospira Australia Pty Ltd | Liquid pharmaceutical formulations of docetaxel |
EP1946747A1 (en) * | 2007-01-17 | 2008-07-23 | Sandoz AG | Pharmaceutical composition of improved stability containing taxane derivatives |
WO2008089706A1 (en) * | 2007-01-23 | 2008-07-31 | Heaton A.S. | A two-component taxane containing pharmaceutical composition |
EP1978953A1 (en) * | 2006-01-30 | 2008-10-15 | Quiral Quimica Do Brasil | Pharmaceutical compositions containing docetaxel and a degradation inhibitor and a process for obtaining the same. |
ES2344674A1 (en) * | 2008-08-07 | 2010-09-02 | Gp Pharm, S.A. | Injectable taxane pharmaceutical composition |
CN101396354B (en) * | 2007-09-30 | 2010-12-01 | 江苏恒瑞医药股份有限公司 | Stable taxabe compound liquid combination and preparation method and use thereof |
JP2011513299A (en) * | 2008-02-29 | 2011-04-28 | ドン−エー ファーム.カンパニー リミテッド | Single liquid stable pharmaceutical composition containing docetaxel |
US8044093B2 (en) * | 2006-02-20 | 2011-10-25 | Beijing Century Biocom Pharmaceutical Technology Co., Ltd. | Pharmaceutical compositions comprising docetaxel and methods for preparation thereof |
US20150056270A1 (en) * | 2012-03-22 | 2015-02-26 | Ensuiko Sugar Refining Co., Ltd. | Method for producing liposome encapsulating paclitaxel monoglycoside and/or docetaxel monoglycoside |
US9545487B2 (en) | 2012-04-13 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Dispenser with encoding means |
US20170087121A1 (en) * | 2015-09-30 | 2017-03-30 | Athenex HK Innovative Limited | Oral taxane compositions and methods |
US9682202B2 (en) | 2009-05-18 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and atomizer |
US9724482B2 (en) | 2009-11-25 | 2017-08-08 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9757750B2 (en) | 2011-04-01 | 2017-09-12 | Boehringer Ingelheim International Gmbh | Medicinal device with container |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10004857B2 (en) | 2013-08-09 | 2018-06-26 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10099022B2 (en) | 2014-05-07 | 2018-10-16 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10124129B2 (en) | 2008-01-02 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Dispensing device, storage device and method for dispensing a formulation |
US10124125B2 (en) | 2009-11-25 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10195374B2 (en) | 2014-05-07 | 2019-02-05 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
US11629367B2 (en) | 2017-01-16 | 2023-04-18 | Nansha Biologies (HK) Limited | Systems and methods for production of recombinant IL-11 in yeast |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100595270C (en) * | 2006-04-12 | 2010-03-24 | 中国科学院大连化学物理研究所 | Microorganism capable of hydrolyzing glycosyl to hydroxyl and application thereof |
JO3685B1 (en) * | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | Non-aqueous taxane nanodispersion formulations and methods of using the same |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5504102A (en) * | 1993-09-29 | 1996-04-02 | Bristol-Myers Squibb Company | Stabilized pharmaceutical composition and stabilizing solvent |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601675B1 (en) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | TAXOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
FR2678833B1 (en) * | 1991-07-08 | 1995-04-07 | Rhone Poulenc Rorer Sa | NEW PHARMACEUTICAL COMPOSITIONS BASED ON DERIVATIVES OF THE TAXANE CLASS. |
NZ258044A (en) * | 1992-11-27 | 1995-12-21 | Faulding F H & Co Ltd | Pharmaceutical composition comprising taxol, solubilising agent, an acid and an organic solvent |
ATE274347T1 (en) * | 1992-11-27 | 2004-09-15 | Mayne Pharma Usa Inc | STABLE INJECTABLE PACLITAXEL SOLUTION |
FR2698543B1 (en) * | 1992-12-02 | 1994-12-30 | Rhone Poulenc Rorer Sa | New taxoid-based compositions. |
US5681846A (en) * | 1995-03-17 | 1997-10-28 | Board Of Regents, The University Of Texas System | Extended stability formulations for paclitaxel |
-
1996
- 1996-12-19 AU AU12949/97A patent/AU724842B2/en not_active Withdrawn - After Issue
- 1996-12-19 WO PCT/US1996/020187 patent/WO1997023208A1/en not_active Application Discontinuation
- 1996-12-19 CA CA002240595A patent/CA2240595A1/en not_active Abandoned
- 1996-12-19 CN CN96199939A patent/CN1209059A/en active Pending
- 1996-12-19 EP EP96943805A patent/EP0876145A4/en not_active Ceased
- 1996-12-20 KR KR1019960069000A patent/KR970032859A/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5504102A (en) * | 1993-09-29 | 1996-04-02 | Bristol-Myers Squibb Company | Stabilized pharmaceutical composition and stabilizing solvent |
Non-Patent Citations (1)
Title |
---|
See also references of EP0876145A4 * |
Cited By (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1221908A1 (en) * | 1995-10-26 | 2002-07-17 | Ivax Research, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
EP1221908A4 (en) * | 1995-10-26 | 2002-10-09 | Baker Norton Pharma | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
US6964946B1 (en) | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
WO2000020036A1 (en) * | 1998-10-02 | 2000-04-13 | Abbott Laboratories | Pharmaceutical compositions containing paclitaxel |
AU759034B2 (en) * | 1998-10-02 | 2003-04-03 | Abbott Laboratories | Pharmaceutical compositions containing paclitaxel |
EP1479382A1 (en) * | 1999-06-18 | 2004-11-24 | IVAX Research, Inc. | Oral pharmaceutical compositions containing taxanes and methods for treatment employing the same |
WO2002043765A2 (en) * | 2000-11-28 | 2002-06-06 | Transform Pharmaceuticals, Inc. | Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof |
WO2002043765A3 (en) * | 2000-11-28 | 2002-11-21 | Transform Pharmaceuticals Inc | Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof |
EP1904052A1 (en) * | 2005-06-17 | 2008-04-02 | Hospira Australia Pty Ltd | Liquid pharmaceutical formulations of docetaxel |
EP2138164A1 (en) * | 2005-06-17 | 2009-12-30 | Hospira Australia Pty Ltd | Liquid pharmaceutical formulations of docetaxel |
EP2308467A3 (en) * | 2005-06-17 | 2011-06-22 | Hospira Australia Pty Ltd | Liquid pharmaceutical formulations of docetaxel |
JP2008543789A (en) * | 2005-06-17 | 2008-12-04 | ホスピラ オーストラリア ピーティーワイ エルティーディー | Docetaxel liquid pharmaceutical formulation |
EP1904052A4 (en) * | 2005-06-17 | 2008-12-10 | Hospira Australia Pty Ltd | Liquid pharmaceutical formulations of docetaxel |
WO2007020085A3 (en) * | 2005-08-19 | 2007-11-08 | Sandoz Ag | Compositions containing taxane derivatives for intravenous injection |
WO2007020085A2 (en) * | 2005-08-19 | 2007-02-22 | Sandoz Ag | Compositions containing taxane derivatives for intravenous injection |
EP1978953A1 (en) * | 2006-01-30 | 2008-10-15 | Quiral Quimica Do Brasil | Pharmaceutical compositions containing docetaxel and a degradation inhibitor and a process for obtaining the same. |
US8044093B2 (en) * | 2006-02-20 | 2011-10-25 | Beijing Century Biocom Pharmaceutical Technology Co., Ltd. | Pharmaceutical compositions comprising docetaxel and methods for preparation thereof |
WO2007124700A3 (en) * | 2006-05-03 | 2007-12-21 | I Q A A S | Pharmaceutical composition containing taxane derivative destined for the preparation of an infusion solution, method of preparation thereof and use thereof |
WO2007134354A1 (en) * | 2006-05-23 | 2007-11-29 | Ebewe Pharma Ges.M.B.H. Nfg. Kg | Pharmaceutical formulation |
WO2008087076A1 (en) * | 2007-01-17 | 2008-07-24 | Sandoz Ag | Pharmaceutical composition of improved stability containing taxane derivatives |
EP1946747A1 (en) * | 2007-01-17 | 2008-07-23 | Sandoz AG | Pharmaceutical composition of improved stability containing taxane derivatives |
WO2008089706A1 (en) * | 2007-01-23 | 2008-07-31 | Heaton A.S. | A two-component taxane containing pharmaceutical composition |
CN101396354B (en) * | 2007-09-30 | 2010-12-01 | 江苏恒瑞医药股份有限公司 | Stable taxabe compound liquid combination and preparation method and use thereof |
US10124129B2 (en) | 2008-01-02 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Dispensing device, storage device and method for dispensing a formulation |
JP2011513299A (en) * | 2008-02-29 | 2011-04-28 | ドン−エー ファーム.カンパニー リミテッド | Single liquid stable pharmaceutical composition containing docetaxel |
ES2344674A1 (en) * | 2008-08-07 | 2010-09-02 | Gp Pharm, S.A. | Injectable taxane pharmaceutical composition |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
US9682202B2 (en) | 2009-05-18 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and atomizer |
US10124125B2 (en) | 2009-11-25 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9724482B2 (en) | 2009-11-25 | 2017-08-08 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9757750B2 (en) | 2011-04-01 | 2017-09-12 | Boehringer Ingelheim International Gmbh | Medicinal device with container |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
US20160256566A2 (en) * | 2012-03-22 | 2016-09-08 | Ensuiko Sugar Refining Co., Ltd. | Method for producing liposome encapsulating paclitaxel monoglycoside and/or docetaxel monoglycoside |
US10682330B2 (en) * | 2012-03-22 | 2020-06-16 | Ensuiko Sugar Refining Co., Ltd. | Method for producing liposome encapsulating paclitaxel monoglycoside and/or docetaxel monoglycoside |
US20150056270A1 (en) * | 2012-03-22 | 2015-02-26 | Ensuiko Sugar Refining Co., Ltd. | Method for producing liposome encapsulating paclitaxel monoglycoside and/or docetaxel monoglycoside |
US10220163B2 (en) | 2012-04-13 | 2019-03-05 | Boehringer Ingelheim International Gmbh | Nebuliser with coding means |
US9545487B2 (en) | 2012-04-13 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Dispenser with encoding means |
US10894134B2 (en) | 2013-08-09 | 2021-01-19 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US11642476B2 (en) | 2013-08-09 | 2023-05-09 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10004857B2 (en) | 2013-08-09 | 2018-06-26 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10099022B2 (en) | 2014-05-07 | 2018-10-16 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10195374B2 (en) | 2014-05-07 | 2019-02-05 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
US10835511B2 (en) | 2015-09-30 | 2020-11-17 | Athenex HK Innovative Limited | Oral taxane compositions and methods |
EP3355881A4 (en) * | 2015-09-30 | 2019-05-08 | Athenex HK Innovative Limited | Oral taxane compositions and methods |
KR20180093880A (en) * | 2015-09-30 | 2018-08-22 | 아테넥스 에이치케이 이노베이티브 리미티드 | Taxane compositions and methods for oral use |
TWI715636B (en) * | 2015-09-30 | 2021-01-11 | 香港商慧源香港創新有限公司 | Oral taxane compositions and methods |
US20170087121A1 (en) * | 2015-09-30 | 2017-03-30 | Athenex HK Innovative Limited | Oral taxane compositions and methods |
AU2016333292B2 (en) * | 2015-09-30 | 2021-11-11 | Athenex HK Innovative Limited | Oral taxane compositions and methods |
JP2022016636A (en) * | 2015-09-30 | 2022-01-21 | エイジネックス・ホンコン・イノヴェイティヴ・リミテッド | Oral taxane compositions and methods |
JP7227334B2 (en) | 2015-09-30 | 2023-02-21 | エイジネックス・ホンコン・イノヴェイティヴ・リミテッド | Oral taxane compositions and methods |
JP2018529778A (en) * | 2015-09-30 | 2018-10-11 | エイジネックス・ホンコン・イノヴェイティヴ・リミテッドAthenex Hk Innovative Limited | Oral taxane compositions and methods |
KR102656954B1 (en) * | 2015-09-30 | 2024-04-12 | 아테넥스 에이치케이 이노베이티브 리미티드 | Oral taxane compositions and methods |
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US11629367B2 (en) | 2017-01-16 | 2023-04-18 | Nansha Biologies (HK) Limited | Systems and methods for production of recombinant IL-11 in yeast |
Also Published As
Publication number | Publication date |
---|---|
AU1294997A (en) | 1997-07-17 |
EP0876145A1 (en) | 1998-11-11 |
AU724842B2 (en) | 2000-09-28 |
EP0876145A4 (en) | 1999-04-21 |
CN1209059A (en) | 1999-02-24 |
CA2240595A1 (en) | 1997-07-03 |
KR970032859A (en) | 1997-07-22 |
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