US20060161245A1 - Interlocking endoluminal device - Google Patents
Interlocking endoluminal device Download PDFInfo
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- US20060161245A1 US20060161245A1 US11/385,621 US38562106A US2006161245A1 US 20060161245 A1 US20060161245 A1 US 20060161245A1 US 38562106 A US38562106 A US 38562106A US 2006161245 A1 US2006161245 A1 US 2006161245A1
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- outer member
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2002/065—Y-shaped blood vessels
- A61F2002/067—Y-shaped blood vessels modular
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- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
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- Materials For Medical Uses (AREA)
Abstract
An endoluminal device comprises at least a first member and a second member, which may be modular. The first member comprises a first trunk portion, a first midsection comprising a first opening, and a first leg portion. The second member comprises a second trunk portion, a second midsection comprising a second opening, and a second leg portion. The device has an assembled configuration in which the first member and second member are interlocked with one another with the second trunk portion coaxially contained within the first trunk portion, the second leg portion protruding through the first opening, and the second opening facing the first leg portion. The second midsection may have a leg stump portion that protrudes into the first leg portion of the first member in the assembled configuration. A system and method for deploying the device may use identical catheters for deploying the two members.
Description
- This application is a continuation of U.S. patent application Ser. No. 10/010,628, filed Nov. 7, 2001, the contents of which are incorporated herein by reference.
- This invention relates generally to endoluminal devices and, more specifically, to endoluminal devices such as stents, grafts, and stent-grafts.
- A stent is an elongated device used to support an intraluminal wall. In the case of a stenosis, a stent provides an unobstructed conduit through a body lumen in the area of the stenosis. Such a stent may also have a prosthetic graft layer of fabric or covering lining the inside and/or outside thereof. Such a covered stent is commonly referred to in the art as an intraluminal prosthesis, an endoluminal or endovascular graft (EVG), or a stent-graft. As used herein, however, the term “stent” is a shorthand reference referring to a covered or uncovered such device.
- A covered stent may be used, for example, to treat a vascular aneurysm by removing the pressure on a weakened part of an artery so as to reduce the risk of rupture. Typically, a stent is implanted in a blood vessel at the site of a stenosis or aneurysm endoluminally, i.e. by so-called “minimally invasive techniques” in which the stent, restrained in a radially compressed configuration by a sheath or catheter, is delivered by a stent delivery system or “introducer” to the site where it is required. The introducer may enter the body from an access location outside the body, such as through the patient's skin, or by a “cut down” technique in which the entry blood vessel is exposed by minor surgical means. The term “proximal” as used herein refers to portions of the stent or delivery system relatively closer to this access location, whereas the term “distal” is used to refer to portions farther from the access location.
- When the introducer has been threaded into the body lumen to the stent deployment location, the introducer is manipulated to cause the stent to be ejected from the surrounding sheath or catheter in which it is restrained (or alternatively the surrounding sheath or catheter is retracted from the stent), whereupon the stent expands to a predetermined diameter at the deployment location, and the introducer is withdrawn. Stent expansion may be effected by spring elasticity, balloon expansion, or by the self-expansion of a thermally or stress-induced return of a memory material to a pre-conditioned expanded configuration.
- Among the many applications for stent-grafts is for deployment in branching lumen, and more specifically for bifurcated lumen, such as for repair of abdominal aortic aneurysms (AAA). Various stent-graft configurations are known in the art for bifurcated applications, including single-piece (“unitary”) designs and modular designs. Bifurcated devices, however, may involve special tooling and procedures for their manufacture that result in high cycle time and low yields, may utilize relatively large-profile delivery systems or specialized delivery systems, and in general may be relatively complex in design and implementation. Modular devices typically also have a risk of leaks in the seals between the modular components. Thus, it is desirable to provide a modular endoluminal device, such as a bifurcated stent-graft, that accommodates a branching flow path yet minimizes drawbacks often associated with bifurcated and/or modular devices.
- In accordance with this invention, there is provided an endoluminal device comprising a first member and a second member. The first member comprises a first trunk portion, a first midsection comprising a first opening, and a first leg portion. The second member comprises a second trunk portion, a second midsection comprising a second opening, and a second leg portion. The device has an assembled configuration in which the first member and second member are interlocked with one another with the second trunk portion coaxially contained within the first trunk portion, the second leg portion protruding through the first opening, and the second opening facing the first leg portion. The second midsection may further comprise a leg stump portion that protrudes into the first leg portion of the first member in the assembled configuration.
- The first member and the second member each may further comprise a stent having a covering inside, outside, or inside and outside of the stent. The covering may comprise a textile, a plastic, or a combination thereof. The first member may comprise an uncovered portion of the stent, such as an uncovered portion adapted to be located at an intersection of a renal lumen with the aorta. The first member may comprise a partial inside covering and the second member may comprise an outside covering, where the first member has no inside covering in an interlocking portion adapted to contact the outside covering of the second member.
- The invention also comprises a modular endoluminal device for deployment in a body lumen comprising a main lumen, a first branch lumen, a second branch lumen, and an internal fluid flowing in a first direction from the main lumen into the first and second branch lumens. The device comprises a first member for directing the fluid from the main lumen into the first branch lumen and a second member for directing the fluid from the main lumen into the second branch lumen. The device, therefore, accommodates a branching fluid flow. The first member and the second member are adapted to interlock together such that the fluid flow forces the second member against the first member in a sealing relationship. The second member may comprise at least one impingement area on which the fluid flow impinges to force the second member against the first member.
- A system for deployment of an endoluminal device of this invention may comprise a first introducer for deploying the first member into a body lumen and having a first profile; and a second introducer, having a second profile essentially identical to the first profile, for deploying the second member into the body lumen.
- The invention also comprises a method of deploying an endoluminal device of the present invention in a deployment location in a branched lumen comprising a main lumen, a first branch lumen, and a second branch lumen. The method comprises the steps of inserting a first introducer containing the first member into the branched lumen from a first proximal location, and deploying the first member with the first trunk portion in the main lumen and the first leg portion in the first branch lumen. A second introducer containing the second member is then inserted into the branched lumen from a second proximal location and the second member is deployed such that the second member is interlocked with the first member in the assembled configuration with the second trunk portion coaxially contained within the first trunk portion, the second leg portion protruding through the first opening into the second branch lumen, and the second opening facing the first leg portion.
- It is to be understood that both the foregoing general description and the following detailed description are exemplary, but not restrictive, of the invention.
- The invention is best understood from the following detailed description when read in connection with the accompanying drawing, in which:
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FIG. 1 is a plan view illustration showing an exemplary embodiment of a device of the present invention; -
FIG. 2 is a longitudinal section view showing another exemplary embodiment of a device of the present invention; -
FIG. 3 is a cross-sectional illustration of a portion of an exemplary wall taken across line 3-3 inFIG. 1 ; -
FIG. 4 is a plan view illustration of an exemplary tapered member of the present invention; and -
FIG. 5 is a plan view illustration of an exemplary member of the present invention having a straight leg design. - The invention will next be illustrated with reference to the figures wherein the same numbers indicate similar elements in all figures. Such figures are intended to be illustrative rather than limiting and are included herewith to facilitate the explanation of the apparatus of the present invention.
- Referring now to
FIG. 1 , there is shown an exemplaryendoluminal device 10 of this invention.Device 10 may be said to be “modular” in that it is constructed of more than one standardized, although not necessarily identical, units. In particular,device 10 comprises twomembers First member 12 comprises afirst trunk portion 14, afirst midsection 16 comprising afirst opening 17, and afirst leg portion 18.Second member 22 comprises asecond trunk portion 24, asecond midsection 26 comprising asecond opening 27, and asecond leg portion 28.First member 12 andsecond member 22 are adapted to interlock with one another in an assembled configuration in whichsecond trunk portion 24 is coaxially contained withinfirst trunk portion 14,second leg portion 28 protrudes through thefirst opening 17, and second opening 27 facesfirst leg portion 18. First opening 17 may have a greater area than the second opening 27. The shape offirst opening 17 may generally be the shape of the outer periphery of the portion ofsecond member 22 which extends through the opening. The shape ofsecond opening 27 may generally be suitable to be an extension of the flow path defined byfirst member 12. - Referring now to
FIG. 2 , there is shown another exemplaryendoluminal device 100.Endoluminal device 100 also comprises first andsecond members respective trunk portions midsections openings leg portions members Second midsection 26 of secondmodular member 122, however, further comprises aleg stump portion 30opposite leg portion 28.Leg stump portion 30 has anopen end 32 comprising opening 27.Leg stump portion 30 is adapted to protrude into thefirst leg portion 18 whenfirst member 112 andsecond member 122 are interlocked.Leg stump portion 30 serves to further stabilizesecond member 122 withinfirst member 112, and may extend intoleg portion 18 any suitable length. -
Device 100 shown inFIG. 2 further comprises aseal ring 40 intrunk portion 14 offirst member 112.Seal ring 40 may comprise any circumferential area of the device having greater sealing properties than the surrounding areas of the device. For example,device 100 may comprise a stent that exerts a certain radial force per unit length throughout the stent, but the seal ring portion exerts a greater radial force. Alternatively, the stent may have a covering comprising one type of material over much of the stent surface area and a different material in the area of the seal ring. For example, the material in the seal ring may comprise a knit material with a heavier texture than the surrounding material. The greater sealing properties of the underlying stent may result from the use of a first stent pattern, such as a woven mesh with a first amount of open area between filaments, in the area surrounding the seal ring, and a second stent pattern, such as a more densely woven mesh with a second, lesser amount of open area between filaments, in the seal ring itself. Other embodiments of seal rings suitable for use in this invention are disclosed in U.S. patent application Ser. No. 09/898,936 entitled IMPLANT HAVING IMPROVED FIXATION TO A BODY LUMEN AND METHOD FOR IMPLANTING THE SAME by Paul DiCarlo and filed on Jul. 3, 2001, incorporated herein by reference. Any seal ring embodiment may be used, however, such as but not limited to embodiments described in U.S. Pat. No. 5,575,818 to Pinchuk, incorporated herein by reference. Seal rings may be located anywhere along the body of the first or second member where desired. For example, seal rings may be particularly useful at the distal or proximal ends of the members for sealing against the lumen wall, as illustrated byseal ring 40. Seal rings may also be useful in the first member opening 17 or on the corresponding portion ofsecond member - The respective members of
endoluminal devices stent 42 having at least a partial covering 44 inside, outside, or inside and outside of the stent. The stent itself may be any type of stent known in the art, such as a filamentary stent or a stent fabricated by laser or otherwise cutting a preformed tube or sheet to be rolled into a tube. The stent may also comprise any stent material known in the art, such as a plastically deformable material such as stainless steel, or a superelastic material or shape-memory material, such as nitinol, or some combination thereof. Accordingly, the stent may be balloon expandable, self-expanding, or some combination thereof. The stent construction is not limited, however, to any particular design, architecture, fabrication method, deployment method, or materials. - Covering 44 may comprise a textile, such as a knit or woven textile, a plastic, such as ePTFE or urethane, or a combination thereof. Referring now to
FIG. 3 , there is shown a cross-section of an exemplary device taken across line 3-3 inFIG. 1 , with the inner surface of the device at the bottom and the outer surface of the device at the top. As shown inFIG. 3 , the device may comprise astent 42 have both an outside ePTFE covering 50 and an inside ePTFE covering 52. The outside ePTFE covering 50 may further comprise a textile covering 54, such as a knit or woven covering as shown inFIG. 3 . The textile covering may, for example, comprise stretchable PET or polyester yarn. In an alternative embodiment, the stent may have no inner ePTFE covering 52 or no outer textile covering 54. Any combination of the coverings, however, may be present. - The covering configuration may be the same throughout each member, or may vary in different areas according to need. For example,
first member 112 may comprise an inside covering 52 andsecond member 122 may comprise anoutside covering 50. The interlocking portion 60 offirst member 12 that is adapted to contact the outside covering of the second member, however, may have no inside covering. - As shown in
FIG. 2 ,first member 112 ofdevice 100 may further comprise an uncoveredportion 56 ofstent 42.Uncovered portion 56 ofstent 42 may comprise a hexagonal cell design, wherein eachcell 46 typically has a pointedapex section 48 at opposite ends, or any design known in the art. As shown inFIG. 2 ,cells 46 are end cells that have pointedapex sections 48 at the proximal end and flat distal ends 47, providing pentagons rather than hexagons. The covered portion ofstent 42 may comprise the same geometric pattern or a different pattern as the end geometry. Forendoluminal device 100, which is shown mounted in a branched lumen, such as the aorta, uncoveredportion 56 may be located at an intersection ofbranch lumens FIG. 2 ,second trunk portion 24 ofsecond member 122 is not distally coextensive withfirst trunk portion 14 offirst member 112. That is,first trunk portion 14 comprises the uncoveredportion 56 which extends further distally thantrunk portion 24. In other designs, however, the two trunk portions may end at the same distal location. - As shown in
FIG. 1 , eachmember FIG. 2 . The overall member design may differ for a tapering leg design as compared to a straight leg design. For example, referring now toFIGS. 4 and 5 , there are shown afirst member 212 with a tapered leg design and afirst member 312 with a straight leg design, respectively. Opening 217 in tapered-legfirst member 212 has essentially an tear-drop or egg shape, and the body offirst member 212 has a smooth curvature. Opening 317 in straight-legfirst member 312 has an almost triangular projection, whereas the body offirst member 312 comprises three distinct sections, a largerdiameter trunk portion 314, atapered midsection 316, and a smallerdiameter leg portion 318. - One advantage of the present invention is that the modular components may be similar in size and profile. For example, any endoluminal device typically has a compressed configuration and an expanded configuration, and each device has a respective diameter or profile in each configuration. For many bifurcated modular devices known in the art, the individual modular members may differ in compressed profile significantly enough that differently sized delivery systems may be required to deploy each member. As used herein, the term “profile” refers to the largest diameter of any portion of a device in a compressed configuration. For the design shown in
FIG. 1 , however, each of the modular members has a similar, if not identical, compressed profile, and can thus be introduced into the body using similarly sized delivery systems. Furthermore, because eachmember Members trunk portion 14, and thus do not require a delivery system any larger than for such a non-branching device. - The similarity in profile and geometry of
first member 12 andsecond member 22 also means that they can be constructed using similar tooling, and the simplicity of both means that they can be constructed without the need for any of the special or complex tooling typically required for bifurcated systems. The simplicity of design also makes the members relatively easier to cover using existing lamination and bonding techniques, resulting in reduced cycle time and higher yields as compared to traditional bifurcated devices. - The interlocking design of the device of this invention also provides certain advantages. As shown in
FIG. 2 , the device is typically deployed in a body lumen comprising amain lumen 70, afirst branch lumen 72, asecond branch lumen 74, and aninternal fluid 76 flowing in a first direction along arrow A from the main lumen into the first and second branch lumens.First member 112 directs fluid 76 frommain lumen 70 intofirst branch lumen 72 andsecond member 22 directs the fluid from the main lumen intosecond branch lumen 74. The shear force offluid 76 flowing in the direction of arrow A tends to forcesecond member 22 againstfirst member 12 in a sealing relationship. That is, the fluid pressure wedgessecond member 22 further into opening 17 ofmember 12, strengthening the seal betweenopening 17 and themember 22. In particular, fluid 76 impinges againstinner crotch 78 insecond member 122 and adds to the force that interlocksmembers leg stump 30, such as the design shown inFIG. 1 , there is a sharper transition between the midsection and the legs that may provide more advantageous hemodynamics because there is no dead space where clots can form. - The endoluminal device of the present invention may be introduced by any known surgical procedure. Preferably, the device is introduced endoluminally, by first introducing
first member 12 to its location, in a proper radial orientation using radiopaque markers such that first opening faces second branch lumen 74 (as shown inFIG. 2 ). Then,second member 22 is deployed by directing a second introducer throughfirst opening 17. In the embodiment shown inFIG. 1 ,second member 22 can be deployed directly to its ultimate location to be desired. In the embodiment shown inFIG. 2 , however, it is desirable to initially deploysecond member 122 at a location slightly upstream of its ultimate resting place to ensure thatleg stump 30 leads tofirst branch lumen 32. Endoluminal fluid flow in the direction of arrow A may then movesecond member 122 proximally untilcrotch 78 ofsecond member 122 abutsfirst member 112. - The deployed device may be inspected using fluoroscopy, optionally following injection of a contrast media, as is known in the art, to ascertain that the
second member 122 has seated properly in abutment withfirst member 112. If necessary, mechanical means, such as but not limited to a hook or tethers attached to the second member, may be used to adjust the position ofsecond member 122. As noted above, the stent may be deployed by any type of expansion known in the art. Regardless of how the stent is initially deployed, balloon devices may be used to model the members into place to conform to the topography of the lumen, as is known in the art. -
First member 112 may be introduced from a proximal location downstream of the deployment location throughfirst branch lumen 72, andsecond member 122 introduced from a proximal location throughbranch lumen 74, or one or both members may be introduced throughmain lumen 70 from proximal locations upstream of the deployment location. - Furthermore, although illustrated and described herein with reference to certain specific embodiments, the present invention is nevertheless not intended to be limited to the details shown. Rather, various modifications may be made in the details within the scope and range of equivalents of the claims and without departing from the spirit of the invention.
Claims (14)
1. A modular endoluminal device comprising an outer member and an inner member, the outer member and inner member each comprising a stent-graft, a fluid inlet opening, a first fluid exit opening, and a second fluid exit opening, the device having an assembled configuration in which the inner member fits partially inside the outer member and partially protrudes through the outer member first exit opening such that the inner member inlet opening aligns with the outer member inlet opening and the inner member first exit opening aligns with the outer member second exit opening, the device adapted to receive a fluid stream through the aligned inner and outer member inlet openings and to discharge the fluid from the device in two discharge streams, one through each of the second fluid exit openings.
2. The endoluminal device of claim 1 , wherein the outer member further comprises a seal ring.
3. The endoluminal device of claim 2 , wherein the seal ring is positioned adjacent the fluid inlet opening.
4. The endoluminal device of claim 2 , wherein the seal ring is positioned adjacent the first fluid exit opening.
5. The endoluminal device of claim 1 , wherein at least one stent-graft comprises a textile, a plastic, or a combination thereof.
6. The endoluminal device of claim 1 , wherein the device is adapted to be mounted in an aorta and the stent-graft comprises an uncovered stent portion positioned to be located at an intersection of a renal lumen with the aorta.
7. The endoluminal device of claim 6 , wherein the uncovered stent portion comprises a hexagonal cell design.
8. The endoluminal device of claim 1 , wherein each of the inner member and the outer member has a tapered diameter.
9. The endoluminal device of claim 1 , wherein the fluid inlet opening is located at a distal end of each member, and the fluid inlet opening of the inner member is positioned proximal the fluid inlet opening of the outer member in the assembled configuration.
10. The endoluminal device of claim 1 , wherein the fluid inlet opening is located at a distal end of each member, and the fluid inlet opening of the inner member is distally coextensive with the fluid inlet opening of the outer member in the assembled configuration.
11. The device of claim 1 , wherein each of the inner member and the outer member comprises an inside surface and an outside surface, the inner member further comprising at least one impingement area positioned receive fluid flow to force the outside surface of the inner member against the inside surface of the outer member in the assembled configuration.
12. The endoluminal device of claim 1 wherein the inner member further comprises a leg stump portion leading to the first fluid exit opening, the outer member further comprises a leg portion leading to the second fluid exit, and the leg stump portion protrudes into the leg portion in the assembled configuration.
13. A two-component, bifurcated endoluminal device kit comprising:
a first stent-graft component comprising a trunk portion, a first long leg portion connected to the trunk portion and a short leg portion connected to the trunk portion adjacent the long leg portion; and
a second stent-graft component comprising a trunk portion, a second long leg portion for receiving the short leg, and a long leg receiving aperture;
wherein the first long leg is adapted to be inserted through the long leg receiving aperture, and the short leg is adapted to be inserted into the second long leg, thereby forming a bifurcated endoluminal device.
14. A method for deploying a modular endoluminal device in a deployment location in a branched lumen comprising a main lumen, a first branch lumen, and a second branch lumen, the modular endoluminal device comprising an outer member and an inner member, the outer member and inner member each comprising a stent-graft, a fluid inlet opening, a first fluid exit opening, and a second fluid exit opening, the device having an assembled configuration in which the inner member fits partially inside the outer member, the method comprising:
(a) inserting a first introducer containing the outer member into the branched lumen;
(b) deploying the outer member with the inlet opening in the main lumen, the first exit opening aligned with the first branch lumen, and the second exit opening positioned in the second branch lumen;
(c) inserting a second introducer containing the inner member into the branched lumen;
(d) assembling the device into the assembled configuration by deploying the inner member with the inner member inlet opening aligned with the outer member inlet opening, a portion of the inner member protruding through the outer member first exit opening and terminating at the inner member second exit opening, and the inner member first exit opening aligned with the outer member second exit opening; and
(e) the assembled device receiving endoluminal fluid from the main lumen through the aligned inner and outer member inlet openings and discharging the fluid into the first branch lumen through the inner member second exit opening and into the second branch lumen through the outer member second exit opening.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US11/385,621 US20060161245A1 (en) | 2001-11-07 | 2006-03-21 | Interlocking endoluminal device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US10/010,628 US7029496B2 (en) | 2001-11-07 | 2001-11-07 | Interlocking endoluminal device |
US11/385,621 US20060161245A1 (en) | 2001-11-07 | 2006-03-21 | Interlocking endoluminal device |
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US10/010,628 Continuation US7029496B2 (en) | 2001-11-07 | 2001-11-07 | Interlocking endoluminal device |
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US20060161245A1 true US20060161245A1 (en) | 2006-07-20 |
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US11/385,621 Abandoned US20060161245A1 (en) | 2001-11-07 | 2006-03-21 | Interlocking endoluminal device |
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US10/010,628 Expired - Fee Related US7029496B2 (en) | 2001-11-07 | 2001-11-07 | Interlocking endoluminal device |
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EP (1) | EP1441782B1 (en) |
AT (1) | ATE430533T1 (en) |
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Also Published As
Publication number | Publication date |
---|---|
EP1441782A2 (en) | 2004-08-04 |
WO2003039621A9 (en) | 2003-12-18 |
US20030088306A1 (en) | 2003-05-08 |
DE60232263D1 (en) | 2009-06-18 |
WO2003039621A2 (en) | 2003-05-15 |
ES2326365T3 (en) | 2009-10-08 |
WO2003039621A3 (en) | 2003-11-20 |
US7029496B2 (en) | 2006-04-18 |
AU2002363317A1 (en) | 2003-05-19 |
EP1441782B1 (en) | 2009-05-06 |
ATE430533T1 (en) | 2009-05-15 |
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