US20040182312A1 - Apparatus and method for coating implantable devices - Google Patents
Apparatus and method for coating implantable devices Download PDFInfo
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- US20040182312A1 US20040182312A1 US10/813,845 US81384504A US2004182312A1 US 20040182312 A1 US20040182312 A1 US 20040182312A1 US 81384504 A US81384504 A US 81384504A US 2004182312 A1 US2004182312 A1 US 2004182312A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B13/00—Machines or plants for applying liquids or other fluent materials to surfaces of objects or other work by spraying, not covered by groups B05B1/00 - B05B11/00
- B05B13/02—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work
- B05B13/0221—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work characterised by the means for moving or conveying the objects or other work, e.g. conveyor belts
- B05B13/0235—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work characterised by the means for moving or conveying the objects or other work, e.g. conveyor belts the movement of the objects being a combination of rotation and linear displacement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B16/00—Spray booths
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/04—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
- B05D3/0486—Operating the coating or treatment in a controlled atmosphere
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/04—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
- B05D3/0493—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases using vacuum
Definitions
- This invention relates to an apparatus and method for coating implantable devices such as stents.
- Stents act as scaffoldings, functioning to physically hold open and, if desired, to expand the wall of the passageway.
- stents are capable of being compressed, so that they can be inserted through small cavities via catheters, and then expanded to a larger diameter once they are at the desired location.
- Mechanical intervention via stents has reduced the rate of restenosis; restenosis, however, is still a significant clinical problem. Accordingly, stents have been modified to perform not only as a mechanical scaffolding, but also to provide biological therapy.
- Biological therapy can be achieved by medicating the stents.
- Medicated stents provide for the local administration of a therapeutic substance at the diseased site.
- systemic administration of such medication often produces adverse or toxic side effects for the patient.
- Local delivery is a preferred method of treatment in that smaller total levels of medication are administered in comparison to systemic dosages, but are concentrated at a specific site. Local delivery thus produces fewer side effects and achieves more favorable results.
- a common method of medicating a stent is by depositing a polymeric coating, impregnated with the therapeutic substance, on the surface of the stent.
- a polymer dissolved in a solvent is applied to the stent.
- a therapeutic substance can be dissolved or dispersed in the composition.
- the solvent is allowed to evaporate to form the coating.
- the application of the composition can be performed by spraying the composition on the stent or immersing the stent in the composition.
- the solvents employed with the composition can be categorized as having a high vapor pressure or low vapor pressure.
- Non-volatile solvents evaporate very slowly from the composition causing coating defects such as inconsistency in the coating thickness and formation of “cob webs” or “pool webs” between the stent struts.
- a solution to this problem is to coat the stent at elevated temperatures to increase the evaporation rate of the solvent.
- Volatile solvents have the tendency to evaporate very quickly from the composition resulting in a coating which has a powdered consistency and adheres poorly to the surface of the stent. Accordingly, what is needed is an apparatus and process for coating stents that does not suffer from the aforementioned drawbacks.
- a method of forming a coating for an implantable medical device such as a stent.
- the method comprises applying a composition to the stent in an environment having a pressure other than ambient pressure.
- the pressure can be less that 760 torr; for compositions including a volatile solvent, the pressure can be greater than 760 torr.
- the composition can include a polymer, such as an ethylene vinyl alcohol copolymer dissolved in a solvent, such as dimethylacetamide.
- a therapeutic substance can be added to the composition, such as actinomycin D, paclitaxel, docetaxel, or rapamycin.
- the composition can be applied by spraying the composition on the stent.
- the stent can be rotated and/or moved in a linear direction along the longitudinal axis of the stent.
- the stent can be a radially expandable stent, such as a balloon expandable or self-expandable type.
- a method of forming a coating for a stent comprising positioning a stent in a chamber; applying a fluid to the stent; and adjusting the pressure of the chamber to increase or decrease the evaporation rate of the fluid.
- an apparatus for coating implantable medical devices such as stents.
- the apparatus includes a chamber for housing a stent and a pressure controller for adjusting the pressure of the chamber during the coating process to a pressure below or above 760 torr.
- an applicator can be provided for spraying a composition at the stent.
- a support assembly holds the stents in the chamber and can be connected to a motor for providing rotational and/or translational motion to the stent.
- a temperature controller can also be provided for adjusting the temperature of the chamber.
- FIG. 1 illustrates a pressure chamber for forming a coating on a stent.
- FIG. 1 there is illustrated a pressure chamber 10 defining a workspace 12 for depositing a composition on a stent 14 for forming a coating.
- a chamber opening (number omitted) can be provided for allowing a user to gain access into workspace 12 .
- a hatch 16 can be placed over the chamber opening for tightly sealing the opening during the deposition process.
- the size of workspace 12 needs to be large enough so as to enclose a support assembly 18 , such as a mandrel, for adequately supporting stent 14 during the coating process.
- Workspace 12 can be large enough so as to support any suitable number of support assemblies 18 and stents 14 .
- support assembly 18 can be connected to a first motor assembly 20 A for rotation of support assembly 18 along the central, longitudinal axis x of stent 14 .
- a second motor assembly 20 B can be additionally provided for translational movement of support assembly 18 in a linear direction, back and forth, along a railing 22 .
- the rotational and translational motion of stent 14 during the application of the composition can result in a more uniform deposition of the coating.
- An applicator 24 such as a spray valve, penetrates through the wall of pressure chamber 10 and is positioned in the vicinity of stent 14 .
- Commercial applicators are available from Spray Systems Co., EFD International Inc., and Badger Air-Brush Co., one specific model of which is the EFD 780S spray device with VALVEMATE 7040 control system.
- applicator 24 can be placed entirely within pressure chamber 10 .
- the nose of applicator 24 can be positioned at any suitable distance away from stent 14 , for example at about 1 cm to about 10 cm.
- An operator should be capable of adjusting the distance depending on the particular circumstances of the deposition process.
- Applicator 24 is capable of applying the composition at a pressure of, for example, about 10 torr to about 1000 torr.
- support element 18 can be in a vertical position and applicator 24 spraying in a horizontal direction.
- a pressure controller such as a pump 26 is in fluid communication with workspace 12 so as to create pressures below or above 760 torr (1 atm) in pressure chamber 10 .
- a cold trap 28 can be provided for preventing the solvent or condensation from penetrating into pump 26 should pump 26 be used to create a vacuum in pressure chamber 10 .
- a filter 30 such as a mist filter, can also be provided to prevent droplets of coating composition from possibly reaching and damaging pump 26 .
- Other components of pressure chamber 10 can include a throttle valve 32 for opening and closing the communication line to pump 26 , a baratron vacuum gauge 34 for measuring the pressure in workspace 12 independent of the type and composition of the solvent vapor, and an absorbent 36 for capturing the bulk of the composition over-spray.
- Gas such as air
- a diffuser 38 can be used to diffuse or “spread out” the flow of gas so as to minimize disturbance of the spraying process.
- a bleed valve 40 can be used for adjusting the flow rate of gas through diffuser 38 . In addition to rapidly removing the solvent vapor from pressure chamber 10 , bleed valve 40 can also be used to control the chamber pressure by working in concert with throttle valve 32 .
- Pressure chamber 10 can also be connected to a heating and/or cooling source 44 so as to control the temperature of workspace 12 .
- a cooler deposition environment such as temperatures of less than 50° C. may be preferred depending on the chemical stability of the therapeutic substance and the type solvent used.
- an internal component such as heating and/or cooling coils, can be provided.
- the surface of stent 14 should be clean and free from contaminants that may be introduced during manufacturing. However, the surface of stent 14 requires no particular surface treatment to retain the applied coating.
- Stent 14 is mounted on mandrel 18 and the composition is sprayed via applicator 24 at a pressure of, for example between 10 to 1000 torr. During the spraying of the composition, stent 14 can be rotated at about 1 to about 120 rotations per minute. Stent 14 can also be moved in a linear direction at speed of about 1 to about 20 cm/sec.
- the temperature of chamber 10 should be maintained at a temperature that does not adversely affect the therapeutic substance or the coating process—for example at about 20° C. to about 50° C.
- compositions have been applied in short bursts, interrupted by the drying of the composition between each application step to minimize coating defects. Reducing the pressure of chamber 10 below ambient pressure during the coating process allows the solvent to evaporate more rapidly.
- the pressure employed in pressure camber 10 depends on the type of solvent employed. Table 1 is an exemplary list of non-volatile solvents and the suitable range of pressure which can be used in the process of the present invention: TABLE 1 Exemplary Pressure Ranges Solvent torr @ 20° C. Dimethylsulfoxide 0.8- ⁇ 760 Dimethlacetamide 0.9- ⁇ 760 Dimethylformamide 5.4- ⁇ 760
- the embodiments of the composition can be prepared by conventional methods wherein all components are combined, then blended. More particularly, in accordance to one embodiment, a predetermined amount of a polymer or combination of polymers can be added to a predetermined amount of a solvent or a combination of solvents. If necessary, heating, stirring and/or mixing can be employed to effect dissolution of the polymer(s) into the solvent(s)—for example in an 80° C. water bath for two hours.
- a therapeutic substance can be also added to the composition. The therapeutic substance should be in true solution or saturated in the blended composition. If the therapeutic substance is not completely soluble in the composition, operations including mixing, stirring, and/or agitation can be employed to effect homogeneity of the residues. The therapeutic substance may be added so that dispersion is in fine particles. The mixing of the therapeutic substance can be conducted at ambient pressure and at room temperature.
- the polymer or combination of polymers chosen must be biocompatible and minimize irritation to the vessel wall when the device is implanted.
- the polymer may be either a biostable or a bioabsorbable polymer.
- Bioabsorbable polymers that could be used include poly(hydroxyvalerate), poly(L-lactic acid), polycaprolactone, poly(lactide-co-glycolide), poly(hydroxybutyrate), poly(hydroxybutyrate-co-valerate), polydioxanone, polyorthoester, polyanhydride, poly(glycolic acid), poly(D,L-lactic acid), poly(glycolic acid-co-trimethylene carbonate), polyphosphoester, polyphosphoester urethane, poly(amino acids), cyanoacrylates, poly(trimethylene carbonate), poly(iminocarbonate), copoly(ether-esters) (e.g.
- PEO/PLA polyalkylene oxalates
- polyphosphazenes polyphosphazenes
- biomolecules such as fibrin, fibrinogen, cellulose, starch, collagen and hyaluronic acid.
- biostable polymers with a relatively low chronic tissue response such as polyurethanes, silicones, and polyesters could be used.
- polymers include polyolefins, polyisobutylene and ethylene-alphaolefin copolymers; acrylic polymers and copolymers; vinyl halide polymers and copolymers, such as polyvinyl chloride; polyvinyl ethers, such as polyvinyl methyl ether; polyvinylidene halides, such as polyvinylidene fluoride and polyvinylidene chloride; polyacrylonitrile; polyvinyl ketones; polyvinyl aromatics, such as polystyrene; polyvinyl esters, such as polyvinyl acetate; copolymers of vinyl monomers with each other and olefins, such as ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, and ethylene-vinyl acetate copolymers; polyamides, such as Nylon 66 and polycaprolactam; alkyd resins; polycarbonates; poly
- Ethylene vinyl alcohol is functionally a very suitable choice of polymer.
- the copolymer possesses good adhesive qualities to the surface of a stent, particularly stainless steel surfaces, and has illustrated the ability to expand with a stent without any significant detachment of the copolymer from the surface of the stent.
- the copolymer moreover, allows for good control capabilities over the release rate of the therapeutic substance.
- solvents include chloroform, acetone, water (buffered saline), dimethylsulfoxide (DMSO), propylene glycol methyl ether (PM,) isopropyl alcohol (IPA), n-propyl alcohol, methanol, ethanol, tetrahydrofuran (THF), dimethylformamide (DMF), dimethyl acetamide (DMAC), benzene, toluene, xylene, hexane, cyclohexane, heptane, octane, nonane, decane, decalin, ethyl acetate, butyl acetate, isobutyl acetate, isopropyl acetate, butanol, diacetone alcohol, benzyl alcohol, acetone, 2-butanone, cyclohexanone, dioxane, methylene chloride, carbon tetrachloride, tetrachloro
- the therapeutic substance can include any agent capable of exerting a therapeutic or prophylactic effect in the practice of the present invention such as inhibition of migration and/or proliferation of smooth muscle cells.
- the agent can also be for enhancing wound healing in a vascular site and improving the structural and elastic properties of the vascular site.
- agents include antiproliferative substances as well as antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, antioxidant, and combinations thereof.
- One suitable example of an antiproliferative substance includes actinomycin D—synonyms of which include dactinomycin, actinomycin IV, actinomycin I 1 , actinomycin X 1 , and actinomycin C 1 .
- Suitable antineoplastics include paclitaxel and docetaxel.
- suitable antiplatelets, anticoagulants, antifibrins, and antithrombins include sodium heparin, low molecular weight heparin, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogs, dextran, D-phe-pro-argchloromethylketone (synthetic antithrombin), dipyridamole, glycoprotein IIb/IIIa platelet membrane receptor antagonist, recombinant hirudin, thrombin inhibitor (available from Biogen), and 7E-3B® (an antiplatelet drug from Centocore).
- Suitable antimitotic agents include methotrexate, azathioprine, vincristine, vinblastine, fluorouracil, adriamycin, and mutamycin.
- suitable cytostatic or antiproliferative agents include angiopeptin (a somatostatin analog from Ibsen), angiotensin converting enzyme inhibitors such as CAPTOPRIL (available from Squibb), CILAZAPRIL (available from Hoffman-LaRoche), or LISINOPRIL (available from Merck); calcium channel blockers (such as Nifedipine), colchicine, fibroblast growth factor (FGF) antagonists, fish oil (omega 3-fatty acid), histamine antagonist, LOVASTATIN (an inhibitor of HMG-CoA reductase, a cholesterol lowering drug from Merck), monoclonal antibodies (such as PDGF receptors), nitroprusside, phosphodiesterase inhibitors, prostaglandin inhibitor (available form Glazo), Seramin (a
- the dosage or concentration of the active agent required to produce a favorable therapeutic effect should be less than the level at which the active agent produces toxic effects and greater than the level at which non-therapeutic results are obtained.
- the dosage or concentration of the active agent required to inhibit the desired cellular activity of the vascular region can depend upon factors such as the particular circumstances of the patient; the nature of the trauma; the nature of the therapy desired; the time over which the ingredient administered resides at the vascular site; and if other therapeutic agents are employed, the nature and type of the substance or combination of substances.
- Therapeutic effective dosages can be determined empirically, for example by infusing vessels from suitable animal model systems and using immunohistochemical, fluorescent or electron microscopy methods to detect the agent and its effects, or by conducting suitable in vitro studies. Standard pharmacological test procedures to determine dosages are understood by one of ordinary skill in the art.
- Stent is broadly intended to include self-expandable stents, balloon-expandable stents, and stent-grafts.
- grafts e.g., aortic grafts
- endocardial leads e.g., valves, and the like.
- the underlying structure of the device can be virtually any design.
- Stents are typically defined by a tubular body having a plurality of bands or cylindrical elements interconnected by connecting elements.
- the device can be made of a metallic material or an alloy such as, but not limited to, cobalt chromium alloy (ELGILOY), stainless steel (316L), “MP35N,” “MP20N,” ELASTINITE (Nitinol), tantalum, nickel-titanium alloy, platinum-iridium alloy, gold, magnesium, or combinations thereof.
- ELGILOY cobalt chromium alloy
- stainless steel 316L
- MP35N stainless steel
- MP35N stainless steel
- MP20N ELASTINITE
- tantalum nickel-titanium alloy
- platinum-iridium alloy platinum-iridium alloy
- gold magnesium
- magnesium or combinations thereof.
- MP35N and “MP20N” are trade names for alloys of cobalt, nickel, chromium and molybdenum available from standard Press Steel Co., Jenkintown, Pa.
- MP35N consists of 35% cobalt, 35% nickel, 20% chromium, and 10% molybdenum.
Abstract
A method of forming a coating for an implantable medical device, such as a stent, is provided which includes applying a composition to the device in an environment having a selected pressure. An apparatus is also provided for coating the devices. The apparatus comprises a chamber for housing the device wherein the pressure of the chamber can be adjusted during the coating process.
Description
- This is a Divisional of U.S. Ser. No. 09/872,816 filed on May 31, 2001, allowed.
- 1. Field of the Invention
- This invention relates to an apparatus and method for coating implantable devices such as stents.
- 1. Description of the Background
- Stents act as scaffoldings, functioning to physically hold open and, if desired, to expand the wall of the passageway. Typically, stents are capable of being compressed, so that they can be inserted through small cavities via catheters, and then expanded to a larger diameter once they are at the desired location. Mechanical intervention via stents has reduced the rate of restenosis; restenosis, however, is still a significant clinical problem. Accordingly, stents have been modified to perform not only as a mechanical scaffolding, but also to provide biological therapy.
- Biological therapy can be achieved by medicating the stents. Medicated stents provide for the local administration of a therapeutic substance at the diseased site. In order to provide an efficacious concentration to the treated site, systemic administration of such medication often produces adverse or toxic side effects for the patient. Local delivery is a preferred method of treatment in that smaller total levels of medication are administered in comparison to systemic dosages, but are concentrated at a specific site. Local delivery thus produces fewer side effects and achieves more favorable results.
- A common method of medicating a stent is by depositing a polymeric coating, impregnated with the therapeutic substance, on the surface of the stent. A polymer dissolved in a solvent is applied to the stent. A therapeutic substance can be dissolved or dispersed in the composition. The solvent is allowed to evaporate to form the coating. The application of the composition can be performed by spraying the composition on the stent or immersing the stent in the composition.
- The solvents employed with the composition can be categorized as having a high vapor pressure or low vapor pressure. Non-volatile solvents evaporate very slowly from the composition causing coating defects such as inconsistency in the coating thickness and formation of “cob webs” or “pool webs” between the stent struts. A solution to this problem is to coat the stent at elevated temperatures to increase the evaporation rate of the solvent. However, not all drugs are stable at elevated temperatures. Volatile solvents have the tendency to evaporate very quickly from the composition resulting in a coating which has a powdered consistency and adheres poorly to the surface of the stent. Accordingly, what is needed is an apparatus and process for coating stents that does not suffer from the aforementioned drawbacks.
- In accordance with one aspect of the invention, a method of forming a coating for an implantable medical device, such as a stent, is provided. The method comprises applying a composition to the stent in an environment having a pressure other than ambient pressure. For compositions including a non-volatile solvent, the pressure can be less that 760 torr; for compositions including a volatile solvent, the pressure can be greater than 760 torr. The composition can include a polymer, such as an ethylene vinyl alcohol copolymer dissolved in a solvent, such as dimethylacetamide. Optionally, a therapeutic substance can be added to the composition, such as actinomycin D, paclitaxel, docetaxel, or rapamycin. In accordance to one embodiment, the composition can be applied by spraying the composition on the stent. During the act of applying, the stent can be rotated and/or moved in a linear direction along the longitudinal axis of the stent. The stent can be a radially expandable stent, such as a balloon expandable or self-expandable type.
- In accordance with another aspect of the invention, a method of forming a coating for a stent is provided, comprising positioning a stent in a chamber; applying a fluid to the stent; and adjusting the pressure of the chamber to increase or decrease the evaporation rate of the fluid.
- In accordance with another aspect of the invention, an apparatus for coating implantable medical devices such as stents is provided. The apparatus includes a chamber for housing a stent and a pressure controller for adjusting the pressure of the chamber during the coating process to a pressure below or above 760 torr. In one embodiment, an applicator can be provided for spraying a composition at the stent. A support assembly holds the stents in the chamber and can be connected to a motor for providing rotational and/or translational motion to the stent. A temperature controller can also be provided for adjusting the temperature of the chamber.
- FIG. 1 illustrates a pressure chamber for forming a coating on a stent.
- Embodiments of the Pressure Chamber
- Referring to FIG. 1, there is illustrated a
pressure chamber 10 defining aworkspace 12 for depositing a composition on astent 14 for forming a coating. A chamber opening (number omitted) can be provided for allowing a user to gain access intoworkspace 12. Ahatch 16 can be placed over the chamber opening for tightly sealing the opening during the deposition process. The size ofworkspace 12 needs to be large enough so as to enclose asupport assembly 18, such as a mandrel, for adequately supportingstent 14 during the coating process.Workspace 12 can be large enough so as to support any suitable number ofsupport assemblies 18 andstents 14. - In one embodiment,
support assembly 18 can be connected to afirst motor assembly 20A for rotation ofsupport assembly 18 along the central, longitudinal axis x ofstent 14. Asecond motor assembly 20B can be additionally provided for translational movement ofsupport assembly 18 in a linear direction, back and forth, along arailing 22. The rotational and translational motion ofstent 14 during the application of the composition can result in a more uniform deposition of the coating. - An
applicator 24, such as a spray valve, penetrates through the wall ofpressure chamber 10 and is positioned in the vicinity ofstent 14. Commercial applicators are available from Spray Systems Co., EFD International Inc., and Badger Air-Brush Co., one specific model of which is the EFD 780S spray device with VALVEMATE 7040 control system. To avoid spray rate alterations due to the pressure difference,applicator 24 can be placed entirely withinpressure chamber 10. The nose ofapplicator 24 can be positioned at any suitable distance away fromstent 14, for example at about 1 cm to about 10 cm. An operator should be capable of adjusting the distance depending on the particular circumstances of the deposition process.Applicator 24 is capable of applying the composition at a pressure of, for example, about 10 torr to about 1000 torr. In accordance with an alternative embodiment,support element 18 can be in a vertical position andapplicator 24 spraying in a horizontal direction. - A pressure controller such as a
pump 26 is in fluid communication withworkspace 12 so as to create pressures below or above 760 torr (1 atm) inpressure chamber 10. In one embodiment, acold trap 28 can be provided for preventing the solvent or condensation from penetrating intopump 26 should pump 26 be used to create a vacuum inpressure chamber 10. Afilter 30, such as a mist filter, can also be provided to prevent droplets of coating composition from possibly reaching and damagingpump 26. Other components ofpressure chamber 10 can include athrottle valve 32 for opening and closing the communication line to pump 26, abaratron vacuum gauge 34 for measuring the pressure inworkspace 12 independent of the type and composition of the solvent vapor, and an absorbent 36 for capturing the bulk of the composition over-spray. Gas, such as air, can be pumped or bled intopressure chamber 10 for creating a convection flow insidepressure chamber 10, to actively scavenge the solvent vapor fromworkspace 12 and out throughpump 26 so as to prevent solvent vapor build-up. Adiffuser 38 can be used to diffuse or “spread out” the flow of gas so as to minimize disturbance of the spraying process. Ableed valve 40 can be used for adjusting the flow rate of gas throughdiffuser 38. In addition to rapidly removing the solvent vapor frompressure chamber 10, bleedvalve 40 can also be used to control the chamber pressure by working in concert withthrottle valve 32. -
Pressure chamber 10 can also be connected to a heating and/or coolingsource 44 so as to control the temperature ofworkspace 12. A cooler deposition environment, such as temperatures of less than 50° C. may be preferred depending on the chemical stability of the therapeutic substance and the type solvent used. In lieu of providing an external heating source, an internal component, such as heating and/or cooling coils, can be provided. - Method of Applying the Composition
- To form a coating on a surface of
stent 14, the surface ofstent 14 should be clean and free from contaminants that may be introduced during manufacturing. However, the surface ofstent 14 requires no particular surface treatment to retain the applied coating.Stent 14 is mounted onmandrel 18 and the composition is sprayed viaapplicator 24 at a pressure of, for example between 10 to 1000 torr. During the spraying of the composition,stent 14 can be rotated at about 1 to about 120 rotations per minute.Stent 14 can also be moved in a linear direction at speed of about 1 to about 20 cm/sec. The temperature ofchamber 10 should be maintained at a temperature that does not adversely affect the therapeutic substance or the coating process—for example at about 20° C. to about 50° C. - For a solvent having a low vapor pressure (e.g., below 30 torr at the temperature of application), or in other words non-volatile substances, the solvent evaporates very slowly from the composition, leading to irregularities in the coating thickness and “cob webs” or “pool webs” between the stent struts. Accordingly, compositions have been applied in short bursts, interrupted by the drying of the composition between each application step to minimize coating defects. Reducing the pressure of
chamber 10 below ambient pressure during the coating process allows the solvent to evaporate more rapidly. Rapid evaporation of the solvent allows the composition to be applied continuously for depositing a coating of a suitable thickness or weight while minimizing coating defects such as “pool webs.” The pressure employed inpressure camber 10 depends on the type of solvent employed. Table 1 is an exemplary list of non-volatile solvents and the suitable range of pressure which can be used in the process of the present invention:TABLE 1 Exemplary Pressure Ranges Solvent torr @ 20° C. Dimethylsulfoxide 0.8-<760 Dimethlacetamide 0.9-<760 Dimethylformamide 5.4-<760 - For a solvent having a high vapor pressure (e.g., above 30 torr at the temperature of application), or in other words volatile solvents, the solvent evaporates extremely rapidly from the composition, leading to difficulties in the application of the composition to the stent. Application of such compositions often lead to coatings having powdered consistency and poor adhesion of the coating to the surface of the stent. Increasing the pressure in
pressure chamber 10 above ambient pressure causes the solvent to evaporate more slowly leading to a coating with a smoother surface, more uniform composition, and better adhesion. Table 2 is an exemplary list of volatile solvents and the suitable range of pressure which can be used in the process of the present invention:TABLE 2 Exemplary Pressure Ranges Solvent torr @ 20° C. Toluene >760-2000 n-propanol >760-3400 Acetone >760-9000 - The Composition
- The embodiments of the composition can be prepared by conventional methods wherein all components are combined, then blended. More particularly, in accordance to one embodiment, a predetermined amount of a polymer or combination of polymers can be added to a predetermined amount of a solvent or a combination of solvents. If necessary, heating, stirring and/or mixing can be employed to effect dissolution of the polymer(s) into the solvent(s)—for example in an 80° C. water bath for two hours. A therapeutic substance can be also added to the composition. The therapeutic substance should be in true solution or saturated in the blended composition. If the therapeutic substance is not completely soluble in the composition, operations including mixing, stirring, and/or agitation can be employed to effect homogeneity of the residues. The therapeutic substance may be added so that dispersion is in fine particles. The mixing of the therapeutic substance can be conducted at ambient pressure and at room temperature.
- The polymer or combination of polymers chosen must be biocompatible and minimize irritation to the vessel wall when the device is implanted. The polymer may be either a biostable or a bioabsorbable polymer. Bioabsorbable polymers that could be used include poly(hydroxyvalerate), poly(L-lactic acid), polycaprolactone, poly(lactide-co-glycolide), poly(hydroxybutyrate), poly(hydroxybutyrate-co-valerate), polydioxanone, polyorthoester, polyanhydride, poly(glycolic acid), poly(D,L-lactic acid), poly(glycolic acid-co-trimethylene carbonate), polyphosphoester, polyphosphoester urethane, poly(amino acids), cyanoacrylates, poly(trimethylene carbonate), poly(iminocarbonate), copoly(ether-esters) (e.g. PEO/PLA), polyalkylene oxalates, polyphosphazenes and biomolecules such as fibrin, fibrinogen, cellulose, starch, collagen and hyaluronic acid. Also, biostable polymers with a relatively low chronic tissue response such as polyurethanes, silicones, and polyesters could be used. Other polymers include polyolefins, polyisobutylene and ethylene-alphaolefin copolymers; acrylic polymers and copolymers; vinyl halide polymers and copolymers, such as polyvinyl chloride; polyvinyl ethers, such as polyvinyl methyl ether; polyvinylidene halides, such as polyvinylidene fluoride and polyvinylidene chloride; polyacrylonitrile; polyvinyl ketones; polyvinyl aromatics, such as polystyrene; polyvinyl esters, such as polyvinyl acetate; copolymers of vinyl monomers with each other and olefins, such as ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, and ethylene-vinyl acetate copolymers; polyamides, such as Nylon 66 and polycaprolactam; alkyd resins; polycarbonates; polyoxymethylenes; polyimides; polyethers; epoxy resins; polyurethanes; rayon; rayon-triacetate; cellulose, cellulose acetate; cellulose butyrate; cellulose acetate butyrate; cellophane; cellulose nitrate; cellulose propionate; cellulose ethers; and carboxymethyl cellulose. Ethylene vinyl alcohol is functionally a very suitable choice of polymer. The copolymer possesses good adhesive qualities to the surface of a stent, particularly stainless steel surfaces, and has illustrated the ability to expand with a stent without any significant detachment of the copolymer from the surface of the stent. The copolymer, moreover, allows for good control capabilities over the release rate of the therapeutic substance.
- Representative examples of solvents include chloroform, acetone, water (buffered saline), dimethylsulfoxide (DMSO), propylene glycol methyl ether (PM,) isopropyl alcohol (IPA), n-propyl alcohol, methanol, ethanol, tetrahydrofuran (THF), dimethylformamide (DMF), dimethyl acetamide (DMAC), benzene, toluene, xylene, hexane, cyclohexane, heptane, octane, nonane, decane, decalin, ethyl acetate, butyl acetate, isobutyl acetate, isopropyl acetate, butanol, diacetone alcohol, benzyl alcohol, acetone, 2-butanone, cyclohexanone, dioxane, methylene chloride, carbon tetrachloride, tetrachloroethylene, tetrachloroethane, chlorobenzene, 1,1,1-trichloroethane, formamide, and combination thereof. The solvent should be capable of placing the selected polymer into dissolution at the selected concentration and should not adversely react with the therapeutic substance.
- The therapeutic substance can include any agent capable of exerting a therapeutic or prophylactic effect in the practice of the present invention such as inhibition of migration and/or proliferation of smooth muscle cells. The agent can also be for enhancing wound healing in a vascular site and improving the structural and elastic properties of the vascular site. Examples of agents include antiproliferative substances as well as antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, antioxidant, and combinations thereof. One suitable example of an antiproliferative substance includes actinomycin D—synonyms of which include dactinomycin, actinomycin IV, actinomycin I1, actinomycin X1, and actinomycin C1. Examples of suitable antineoplastics include paclitaxel and docetaxel. Examples of suitable antiplatelets, anticoagulants, antifibrins, and antithrombins include sodium heparin, low molecular weight heparin, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogs, dextran, D-phe-pro-argchloromethylketone (synthetic antithrombin), dipyridamole, glycoprotein IIb/IIIa platelet membrane receptor antagonist, recombinant hirudin, thrombin inhibitor (available from Biogen), and 7E-3B® (an antiplatelet drug from Centocore). Examples of suitable antimitotic agents include methotrexate, azathioprine, vincristine, vinblastine, fluorouracil, adriamycin, and mutamycin. Examples of suitable cytostatic or antiproliferative agents include angiopeptin (a somatostatin analog from Ibsen), angiotensin converting enzyme inhibitors such as CAPTOPRIL (available from Squibb), CILAZAPRIL (available from Hoffman-LaRoche), or LISINOPRIL (available from Merck); calcium channel blockers (such as Nifedipine), colchicine, fibroblast growth factor (FGF) antagonists, fish oil (omega 3-fatty acid), histamine antagonist, LOVASTATIN (an inhibitor of HMG-CoA reductase, a cholesterol lowering drug from Merck), monoclonal antibodies (such as PDGF receptors), nitroprusside, phosphodiesterase inhibitors, prostaglandin inhibitor (available form Glazo), Seramin (a PDGF antagonist), serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. Other therapeutic substances or agents which may be appropriate include alpha-interferon, genetically engineered epithelial cells, rapamycin, and dexamethasone.
- The dosage or concentration of the active agent required to produce a favorable therapeutic effect should be less than the level at which the active agent produces toxic effects and greater than the level at which non-therapeutic results are obtained. The dosage or concentration of the active agent required to inhibit the desired cellular activity of the vascular region can depend upon factors such as the particular circumstances of the patient; the nature of the trauma; the nature of the therapy desired; the time over which the ingredient administered resides at the vascular site; and if other therapeutic agents are employed, the nature and type of the substance or combination of substances. Therapeutic effective dosages can be determined empirically, for example by infusing vessels from suitable animal model systems and using immunohistochemical, fluorescent or electron microscopy methods to detect the agent and its effects, or by conducting suitable in vitro studies. Standard pharmacological test procedures to determine dosages are understood by one of ordinary skill in the art.
- Stent is broadly intended to include self-expandable stents, balloon-expandable stents, and stent-grafts. One of ordinary skill in the art, however, understands that other medical devices on which a polymer can be coated can be used with the practice of the present invention, such as grafts (e.g., aortic grafts), endocardial leads, valves, and the like. The underlying structure of the device can be virtually any design. Stents are typically defined by a tubular body having a plurality of bands or cylindrical elements interconnected by connecting elements. The device can be made of a metallic material or an alloy such as, but not limited to, cobalt chromium alloy (ELGILOY), stainless steel (316L), “MP35N,” “MP20N,” ELASTINITE (Nitinol), tantalum, nickel-titanium alloy, platinum-iridium alloy, gold, magnesium, or combinations thereof. “MP35N” and “MP20N” are trade names for alloys of cobalt, nickel, chromium and molybdenum available from standard Press Steel Co., Jenkintown, Pa. “MP35N” consists of 35% cobalt, 35% nickel, 20% chromium, and 10% molybdenum. “MP20N” consists of 50% cobalt, 20% nickel, 20% chromium, and 10% molybdenum. Devices made from bioabsorbable or biostable polymers could also be used with the blended composition.
- While particular embodiments of the present invention have been shown and described, it will be obvious to those skilled in the art that changes and modifications can be made without departing from the embodiments this invention in its broader aspects and, therefore, the appended claims are to encompass within their scope all such changes and modifications as fall within the true spirit and scope of the embodiments this invention.
- This is a divisional of U.S. Ser. No. 09/872,816, the entire disclosure of which is incorporated by reference.
Claims (24)
1. An apparatus for coating implantable devices, comprising:
a) a chamber in which a coating composition comprising a coating solvent can be applied to an implantable device;
b) a pressure controller for adjusting the pressure of the chamber during the coating process to other than ambient pressure,
wherein other than ambient pressure is greater than 760 torr if the coating solvent is non-volatile, and alternatively, wherein other than ambient pressure is less than 760 torr if the coating solvent is volatile.
2. The apparatus of claim 1 additionally including an applicator for spraying a composition at the device.
3. The apparatus of claim 1 additionally including a support assembly for holding the device during the coating process.
4. The apparatus of claim 1 additionally including means for rotating the device during the coating process.
5. The apparatus of claim 1 additionally including means for moving the device in a linear direction during the coating process.
6. The apparatus of claim 1 additionally including means for creating convection flow within the chamber.
7. The apparatus of claim 1 wherein the coating process comprises the application of the composition to the device and wherein the composition further comprises a polymer and optionally a therapeutic substance.
8. The apparatus of claim 1 additionally including a temperature controller for adjusting the temperature of the chamber.
9. An apparatus for coating implantable devices, comprising:
a) a chamber in which a coating composition comprising a coating solvent can be applied to an implantable device;
b) a pressure controller for adjusting the pressure of the chamber during the coating process to other than ambient pressure,
wherein other than ambient pressure is greater than 760 torr if the coating solvent evaporation rate is to be decreased, and alternatively, wherein other than ambient pressure is less than 760 torr if the coating solvent evaporation rate is to be increased.
10. The apparatus of claim 9 additionally including an applicator for spraying the composition at the device.
11. The apparatus of claim 9 additionally including a support assembly for holding the device during the coating process.
12. The apparatus of claim 9 additionally including means for rotating the device during the coating process.
13. The apparatus of claim 9 additionally including means for moving the device in a linear direction during the coating process.
14. The apparatus of claim 9 additionally including means for creating convection flow within the chamber.
15. The apparatus of claim 9 wherein the coating process comprises the application of the composition to the device and wherein the composition further comprises a polymer and optionally a therapeutic substance.
16. The apparatus of claim 9 additionally including a temperature controller for adjusting the temperature of the chamber.
17. An apparatus for coating implantable devices, comprising:
a) a chamber in which a coating composition comprising a coating solvent can be applied to an implantable device;
b) a pressure controller for selecting the pressure of the chamber during the coating process to a pressure,
wherein pressure is other than ambient pressure and is based on the vapor pressure of the coating solvent.
18. The apparatus of claim 17 additionally including an applicator for spraying the composition at the device.
19. The apparatus of claim 17 additionally including a support assembly for holding the device during the coating process.
20. The apparatus of claim 17 additionally including means for rotating the device during the coating process.
21. The apparatus of claim 17 additionally including means for moving the device in a linear direction during the coating process.
22. The apparatus of claim 17 additionally including means for creating convection flow within the chamber.
23. The apparatus of claim 17 wherein the coating process comprises the application of the composition to the device and wherein the composition further comprises a polymer and optionally a therapeutic substance.
24. The apparatus of claim 17 additionally including a temperature controller for adjusting the temperature of the chamber.
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US7335391B1 (en) | 2008-02-26 |
US20040180132A1 (en) | 2004-09-16 |
US20080102193A1 (en) | 2008-05-01 |
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