DE60035669D1 - Neue in einem hydrogel isolierte cochleat-formulierungen, verfahren zu deren herstellung und deren verwendung zur verabreichung von biologisch aktiven molekülen - Google Patents

Neue in einem hydrogel isolierte cochleat-formulierungen, verfahren zu deren herstellung und deren verwendung zur verabreichung von biologisch aktiven molekülen

Info

Publication number
DE60035669D1
DE60035669D1 DE60035669T DE60035669T DE60035669D1 DE 60035669 D1 DE60035669 D1 DE 60035669D1 DE 60035669 T DE60035669 T DE 60035669T DE 60035669 T DE60035669 T DE 60035669T DE 60035669 D1 DE60035669 D1 DE 60035669D1
Authority
DE
Germany
Prior art keywords
hydrogel
administration
production
biologically active
active molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60035669T
Other languages
English (en)
Other versions
DE60035669T2 (de
Inventor
Leila Zarif
Tuo Jin
Ignacio Segarra
Raphael Mannino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Medicine and Dentistry of New Jersey
Rutgers State University of New Jersey
Biodelivery Sciences Inc
Original Assignee
University of Medicine and Dentistry of New Jersey
Rutgers State University of New Jersey
Biodelivery Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Medicine and Dentistry of New Jersey, Rutgers State University of New Jersey, Biodelivery Sciences Inc filed Critical University of Medicine and Dentistry of New Jersey
Application granted granted Critical
Publication of DE60035669D1 publication Critical patent/DE60035669D1/de
Publication of DE60035669T2 publication Critical patent/DE60035669T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
DE60035669T 1999-01-22 2000-01-24 Neue in einem hydrogel isolierte cochleat-formulierungen, verfahren zu deren herstellung und deren verwendung zur verabreichung von biologisch aktiven molekülen Expired - Lifetime DE60035669T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/235,400 US6153217A (en) 1999-01-22 1999-01-22 Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents
US235400 1999-01-22
PCT/US2000/001684 WO2000042989A2 (en) 1999-01-22 2000-01-24 Novel hydrogel isolated cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules

Publications (2)

Publication Number Publication Date
DE60035669D1 true DE60035669D1 (de) 2007-09-06
DE60035669T2 DE60035669T2 (de) 2008-02-07

Family

ID=22885334

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60035669T Expired - Lifetime DE60035669T2 (de) 1999-01-22 2000-01-24 Neue in einem hydrogel isolierte cochleat-formulierungen, verfahren zu deren herstellung und deren verwendung zur verabreichung von biologisch aktiven molekülen

Country Status (12)

Country Link
US (7) US6153217A (de)
EP (1) EP1143933B1 (de)
JP (1) JP2002535267A (de)
AT (1) ATE367800T1 (de)
AU (1) AU3213300A (de)
CA (1) CA2358505C (de)
CY (1) CY1106916T1 (de)
DE (1) DE60035669T2 (de)
DK (1) DK1143933T3 (de)
ES (1) ES2290019T3 (de)
PT (1) PT1143933E (de)
WO (1) WO2000042989A2 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153217A (en) 1999-01-22 2000-11-28 Biodelivery Sciences, Inc. Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents
WO2001052817A2 (en) * 2000-01-24 2001-07-26 Biodelivery Sciences, Inc. Cochleate formulations and their use for delivering biologically relevant molecules
DE10154464B4 (de) * 2001-11-08 2005-10-20 Max Delbrueck Centrum Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol
US20030219473A1 (en) * 2002-03-26 2003-11-27 Leila Zarif Cochleates made with purified soy phosphatidylserine
US20040092727A1 (en) * 2002-11-13 2004-05-13 Biopharm Solutions Inc. Cochleates without metal cations as bridging agents
CN1674869A (zh) * 2002-08-06 2005-09-28 金拓 非金属阳离子作桥联剂的脂质卷
JP3927887B2 (ja) * 2002-08-09 2007-06-13 本田技研工業株式会社 軸流圧縮機の静翼
US8685428B2 (en) * 2002-12-10 2014-04-01 Advanced Cardiovascular Systems, Inc. Therapeutic composition and a method of coating implantable medical devices
US8980310B2 (en) * 2002-12-31 2015-03-17 Bharat Serums and Vaccines, Ltd. Non-pegylated long-circulating liposomes
WO2004064805A1 (en) * 2003-01-15 2004-08-05 Biodelivery Sciences International, Inc. Cochleate preparations of fragile nutrients
US20050013854A1 (en) 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
JP4789208B2 (ja) 2003-04-09 2011-10-12 バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド タンパク質発現に向けられた渦巻型組成物
DE10322439A1 (de) * 2003-05-19 2004-12-09 Bayer Ag Verfahren und Vorrichtung zur Bestimmung der Isomerenzusammensetzung bei Isocyanat-Herstellprozessen
SE527505C2 (sv) * 2003-06-10 2006-03-28 Anna Imberg Komposita material och partiklar
US20060188573A1 (en) * 2003-06-10 2006-08-24 Anna Imberg Composite materials and particles
EP1674093A4 (de) * 2003-10-15 2009-12-09 Nanoegg Res Lab Inc Verfahren zur kontrolle der teilchengrösse von retinolsäure-nanoteilchen mit einer beschichtung aus polyvalentem anorganischem metallsalz und mit dem kontrollverfahren erhaltene nanoteilchen
CN1859906A (zh) * 2003-10-15 2006-11-08 株式会社纳米卵 含有多价金属无机盐包覆的视黄酸纳米颗粒的组合物
WO2005063213A1 (en) * 2003-12-19 2005-07-14 Biodelivery Sciences International, Inc. Rigid liposomal cochleate and methods of use and manufacture
US20050244522A1 (en) * 2004-04-30 2005-11-03 Carrara Dario Norberto R Permeation enhancer comprising genus Curcuma or germacrone for transdermal and topical administration of active agents
US7494526B2 (en) * 2004-07-14 2009-02-24 Yavitz Edward Q Plant protection and growth stimulation by nanoscalar particle folial delivery
US20060040896A1 (en) * 2004-08-18 2006-02-23 Paringenix, Inc. Method and medicament for anticoagulation using a sulfated polysaccharide with enhanced anti-inflammatory activity
US20070082115A1 (en) * 2005-10-07 2007-04-12 Aimutis William Ronald Jr Methods for inducing satiety, reducing food intake and reducing weight
US20070082030A1 (en) * 2005-10-07 2007-04-12 Aimutis William R Fiber satiety compositions
US20070082107A1 (en) * 2005-10-07 2007-04-12 Aimutis William R Jr Compositions and methods for reducing food intake and controlling weight
US20070082029A1 (en) * 2005-10-07 2007-04-12 Aimutis William R Fiber satiety compositions
WO2008024389A2 (en) * 2006-08-23 2008-02-28 Biodelivery Sciences International, Inc. Amphiphilic nucleotide cochleate compositions and methods of using the same
US20080085354A1 (en) * 2006-10-06 2008-04-10 Teresa Marie Paeschke Controlled hydration of hydrocolloids
CA2672338C (en) 2006-12-15 2017-06-06 National Research Council Of Canada Archaeal polar lipid aggregates for administration to animals
US20090054374A1 (en) * 2007-02-28 2009-02-26 Paringenix, Inc. Methods of treating acute exacerbations of chronic obstructive pulmonary disease
US8591225B2 (en) * 2008-12-12 2013-11-26 Align Technology, Inc. Tooth movement measurement by automatic impression matching
CA2694189A1 (en) * 2007-07-23 2009-01-29 University Of Utah Research Foundation Method for blocking ligation of the receptor for advanced glycation end-products (rage)
US20090047336A1 (en) * 2007-08-17 2009-02-19 Hong Kong Baptist University novel formulation of dehydrated lipid vesicles for controlled release of active pharmaceutical ingredient via inhalation
JP2010539245A (ja) 2007-09-14 2010-12-16 日東電工株式会社 薬物担体
ES2630805T3 (es) 2008-07-14 2017-08-24 Polypid Ltd. Composición de vehículo de fármaco de liberación sostenida
US20100113352A1 (en) 2008-11-06 2010-05-06 Elliott Millstein Retinol formulations and methods for their use
IN2012DN00570A (de) 2009-07-14 2015-06-12 Polypid Ltd
WO2011016043A2 (en) 2009-08-06 2011-02-10 Technion Research & Development Foundation Ltd. Antibiotic drug delivery and potentiation
WO2011031018A2 (ko) * 2009-09-14 2011-03-17 한남대학교 산학협력단 서방형 방출이 가능한 수용성 약물 전달 시스템
WO2011089595A2 (en) * 2010-01-19 2011-07-28 Polypid Ltd. Sustained-release nucleic acid matrix compositions
EP2533762B1 (de) * 2010-02-10 2019-03-27 Biopelle Inc. Retinolformulierungen und verfahren zu ihrer verwendung
CN113018452A (zh) 2011-04-29 2021-06-25 西莱克塔生物科技公司 用于效应性t细胞的抗原特异性缺失的致耐受性合成纳米载体
ES2741282T3 (es) * 2011-05-05 2020-02-10 Matinas Biopharma Nanotechnologies Inc Composiciones de cocleato y métodos de elaboración y uso de las mismas
AU2012278832B2 (en) 2011-07-06 2017-04-20 The Regents Of The University Of California Multiple-enzyme nanocomplexes
WO2013033717A1 (en) 2011-09-02 2013-03-07 The Regents Of The University Of California Enzyme responsive nanocapsules for protein delivery
LT2846809T (lt) 2012-05-09 2021-01-25 Cantex Pharmaceuticals, Inc. Mielosupresijos gydymas
WO2014151775A1 (en) * 2013-03-15 2014-09-25 Robert Bosch Gmbh Heated garment and battery holster
CA2910575C (en) * 2013-05-03 2023-10-24 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers and therapeutic macromolecules for reduced or enhanced pharmacodynamic effects
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
EP3258941A4 (de) 2015-02-17 2018-09-26 Cantex Pharmaceuticals, Inc. Behandlung von durch cxcl12-cxcr4 interaktion privilegierten krebs- und hämatopoetischen stammzellerkrankungen
AU2016226151B2 (en) 2015-03-03 2021-02-25 Matinas Biopharma Nanotechnologies, Inc. Cochleates and methods of using the same to enhance tissue penetration of pharmacologically active agent
AU2016352874B2 (en) * 2015-11-10 2021-06-24 Children's Research Institute, Children's National Medical Center Echinomycin formulation, method of making and method of use thereof
JP6991592B2 (ja) * 2016-07-12 2022-01-12 マティナス バイオファーマ ナノテクノロジーズ，インコーポレーテッド 中枢神経系送達のためのコクリエート化抗真菌化合物及びクリプトコッカス感染症の治療
KR101989789B1 (ko) 2017-11-30 2019-06-18 (주) 에이치엔에이파마켐 포스파티딜세린/음이온계면활성제/염화칼슘을 이용한 코킬레이트
WO2020066471A1 (ja) * 2018-09-28 2020-04-02 株式会社マンダム 化粧料
US20220226465A1 (en) 2021-01-18 2022-07-21 ConserV Bioscience Coronavirus Immunogenic Compositions, Methods and Uses Thereof
WO2024039733A1 (en) 2022-08-16 2024-02-22 Matinas Biopharma Nanotechnologies, Inc. Methods of controlling lipid nanocrystal particle size and lipid nanocrystals produced by such methods
WO2024039729A1 (en) 2022-08-16 2024-02-22 Matinas Biopharma Nanotechnologies, Inc. Antifungal agent encapsulated in a lipid nanocrystal for treating mucormycosis

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663161A (en) * 1985-04-22 1987-05-05 Mannino Raphael J Liposome methods and compositions
US4871488A (en) * 1985-04-22 1989-10-03 Albany Medical College Of Union University Reconstituting viral glycoproteins into large phospholipid vesicles
US4990291A (en) * 1986-04-15 1991-02-05 The United States Of America As Represented By The Secretary Of The Navy Method of making lipid tubules by a cooling process
US5269979A (en) * 1988-06-08 1993-12-14 Fountain Pharmaceuticals, Inc. Method for making solvent dilution microcarriers
AU638271B2 (en) * 1989-06-22 1993-06-24 Nexstar Pharmaceuticals, Inc. Encapsulation process
US5994318A (en) * 1993-10-04 1999-11-30 Albany Medical College Cochleate delivery vehicles
US5643574A (en) * 1993-10-04 1997-07-01 Albany Medical College Protein- or peptide-cochleate vaccines and methods of immunizing using the same
US5840707A (en) * 1993-10-04 1998-11-24 Albany Medical College Stabilizing and delivery means of biological molecules
CA2246754C (en) 1996-02-22 2002-10-22 Raphael James Mannino Cochleate delivery vehicles
US6120751A (en) * 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6153217A (en) 1999-01-22 2000-11-28 Biodelivery Sciences, Inc. Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents

Also Published As

Publication number Publication date
ES2290019T3 (es) 2008-02-16
US20140220109A1 (en) 2014-08-07
US20050186265A1 (en) 2005-08-25
WO2000042989A2 (en) 2000-07-27
US6592894B1 (en) 2003-07-15
US20090028904A1 (en) 2009-01-29
JP2002535267A (ja) 2002-10-22
ATE367800T1 (de) 2007-08-15
US6153217A (en) 2000-11-28
AU3213300A (en) 2000-08-07
US20030228355A1 (en) 2003-12-11
EP1143933A2 (de) 2001-10-17
CA2358505A1 (en) 2000-07-27
US20120294901A1 (en) 2012-11-22
EP1143933B1 (de) 2007-07-25
WO2000042989A3 (en) 2000-11-30
DE60035669T2 (de) 2008-02-07
CY1106916T1 (el) 2012-09-26
CA2358505C (en) 2010-04-06
PT1143933E (pt) 2007-09-03
DK1143933T3 (da) 2007-11-26

Similar Documents

Publication Publication Date Title
DE60035669D1 (de) Neue in einem hydrogel isolierte cochleat-formulierungen, verfahren zu deren herstellung und deren verwendung zur verabreichung von biologisch aktiven molekülen
Wang et al. An enzyme‐responsive polymeric superamphiphile
Matos et al. Alternating current electric field effects on neural stem cell viability and differentiation
DE69630691T2 (de) Liposomal p-Ethoxy Oligonucleotides
ATE66947T1 (de) Verfahren zur herstellung von kleinen, sphaerischen polymerpartikeln.
US10485827B2 (en) Topical eye serum compositions, methods or preparing, and methods of use
DE69102062T2 (de) Immobilisierte polyethylenoxyd-sternmoleküle für bioanwendungen.
ATE204469T1 (de) Verfahren zur herstellung von morphologisch einheitlichen mikrokapseln sowie nach diesem verfahren hergestellte mikrokapseln
DE69913685T2 (de) Verfahren zur mikroverkapselung und elektrostatische behandlung
ES2119250T3 (es) Composiciones y metodos para estimular el crecimiento y diferenciacion de megacariocitos.
ATE180408T1 (de) Herstellung eines arzneimittels zur behandlung von augenentzündung durch blockierung von zelladhäsionsmolekulen
WO2001052817A3 (en) Cochleate formulations and their use for delivering biologically relevant molecules
EP0281679A2 (de) Niedermolekulare Alkalihuminate, Verfahren zur ihrer Herstellung und Verwendung
DE3209098A1 (de) Verfahren zur kultivierung verankerungsabhaengiger zellen
Kawakami et al. Liver plasma membranes and proteoglycan prepared therefrom inhibit the growth of hepatoma cells in vitro
ATE242816T1 (de) Verfahren zur reinigung von hyaluronsäure mit hohem molekulargewicht
DE69911614D1 (de) Komponenten mit niedrigem molekulargewicht aus knorpelgewebe von haien, verfahren zur herstellung und therapeutische verwendungen
Xu et al. Solution–air interface synthesis and growth mechanism of tooth enamel-like hydroxyapatite/chondroitin sulfate films
DE69427234T2 (de) Verfahren zur herstellung von hochtransformierbaren bakterienzellen und dadurch herggestellte zellen
Svarnas et al. Liposomal membrane disruption by means of miniaturized dielectric-barrier discharge in air: liposome characterization
DE50107344D1 (de) Herstellung von polygalakturoniden und ihre verwendung als lebensmittelzusatzstoffe
Santos‐Ebinuma et al. Extraction of natural red colorants from the fermented broth of Penicillium purpurogenum using aqueous two‐phase polymer systems
ATE92075T1 (de) Verfahren zur gewinnung aktiver proteine aus einer biologisch inaktiven form.
Schuster et al. From fibers to micelles using point-mutated amphiphilic peptides
EP0537429B1 (de) Modifizierte Huminate, Verfahren zu ihrer Herstellung und Verwendung

Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: ZARIF, LEILA, NEWARK, NJ 07103-3000, US

Inventor name: JIN, TUO, NEWARK, NJ 07103-3000, US

Inventor name: SEGARRA, IGNACIO, NEWARK, NJ 07103-3000, US

Inventor name: MANNINO, RAPHAEL, NEWARK NJ 07103-3000, US

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KUDLEK & GRUNERT PATENTANWAELTE PARTNERSCHAFT, 803