DE102009008028A1 - Method for manufacturing stack of pharmaceutical foil bag for storing and supplying pharmaceutical wafers for contraception of hormone replacement therapy, involves following one of bags to another bag with markings found at end of edge - Google Patents

Abstract

The method involves stacking pharmaceutical bags (T) under formation of a bag stack so that the pharmaceutical bags are arranged in a sequence in the stack. Markings of the bags are found in marking sections, which are arranged in a sequence. One of the bags with the markings found at an end of a marking edge follows the bag with the markings found at another end of the marking edge. The bags are made of sheet of paper (1) by punching method. A guidance element is provided for guiding the bags to a carrier.

Description

The The present invention relates to a process for producing a Stacks of for storage and provision of drug wafers serving medicine bags. Pharmaceutical wafers contain the drugs in layer form. The pharmaceutical wafers can in particular Hormonal drugs, especially drugs for the Contraception or hormone replacement therapy, included.

State of the art:

Pharmaceutical wafers are sheet-like devices containing pharmaceutically active agents contained in a drug carrier. The active substances in the wafers can be administered, for example, transmucosally, ie via the oral mucosa, by placing the wafers on or under the tongue, whereby the active substance carrier dissolves, thereby releasing the active substances. The wafers are provided enclosed in foil pockets to protect them against mechanical and other environmental influences, such as moisture. According to DE 101 59 746 B4 These pockets may consist of at least one carrier foil and at least one cover foil, wherein at least the areal larger foil has two parallel side edges and between the carrier foil and the cover foil the foil- or sheet-like material (wafer) is enclosed gas- and moisture-proof. Devices for storing and providing the drug wafers may contain foil bags stacked therein. Of course, the drug wafers can also be modified from this, namely, by not necessarily consisting of a larger area film and a smaller area film, but for example from the same size films.

to Taking hormonal drugs, but also other medicines It is important to have the medicines in a given scheme be taken, for example, three times a day or even once a day, with the attending physician setting the regimen. The However, most medicines only become available during one limited period, approximately as long as one to be treated Illness is completely cured. There are, however, too Medicines that last for a very long time must be taken continuously. In these cases It may happen that the drugs are not or not prescribed Time to be taken. Often then the success of one Therapy endangered. Therefore, there has been no lack of attempts In particular, to control the intake of the drug emphasis is placed on self-control by the patient himself.

In order to remedy the aforementioned problems, it has been proposed to provide aids to the patient, with the help of which, despite the distraction of the patient in everyday life, a controlled intake of the medicaments is ensured. For this purpose, for example, devices for receiving the drug packages are described in which the removal of individual tablets is automatically registered. For this are several suggestions in DE 198 50 890 A1 (Dispensing device for medicaments, ie for tablets or the like), DE 197 39 438 A1 and DE 195 16 076 A1 (Packaging for dimensionally stable medicament samples, ie for tablets or the like), DE 198 52 602 A1 (Device and method for reminding a timely intake of medication, ie tablets or the like), DE 102 13 547 C1 (Blister pack), DE 41 34 237 C1 (Device for detecting the removal of a pill from a blister pack), EP 0 191 168 A2 (Device for storage and temporary intake of medicaments, ie of tablets or the like), DE 198 36 100 A1 (Device for storing a medicine container, ie for tablets or the like), DE 102 17 929 A1 (Device for dispensing tablets), US 2004/0050746 A1 (Pill holder and reminder device), WO 01/54646 A2 (Pill dispenser with alarm function), EP 0 166 763 B1 (Tablet dispenser with daily license plate), EP 0 511 726 B1 (Device for holding tablets in blister packs), DE 10 2005 032 015 A1 (Case for receiving a drug package, ie a pack for tablets or the like, as well as their use) and DE 10 2005 048 515 A1 (Solid drug portion dispensers, ie tablets or the like, and its use).

However, there are no proposed controlled use of drug wafers to ensure their safe administration. Although a dispenser for sweets or drugs in wafer form is known, for example DE 101 59746 B4 , However, this device has the disadvantage that a user does not receive any control as to whether or not an intake prescribed for a certain period of time has already been followed. Therefore, it can easily come to a double intake, or the user in general forgets to take the wafer. In particular, for the contraceptive use it is particularly important that the medicines are taken for a very long period without interruption and without irregularities. In this case, the user must be very careful to eat a portion of the medicine without exception every day. To skip a serving would also lead to considerable risks, as would the double intake of a portion of medication on the same day. Since it can happen, especially in stressful situations, that the user ver If the use of medication is to be consumed within the prescribed period of time, there is the problem, especially for this indication, that medicaments wafers have no means of ensuring safe administration. In addition, of course, it is also necessary to provide such means by means of a flawless and inexpensive manufacturing process.

From Therefore, a first task is to find means by which the medicine wafers containing drug pockets for a user be prepared in such a way that this user (s) the wafers in the order provided and in the prescribed Rhythm takes. The device for storage and provision The drug wafer should also be suitable for everyday use be and have the required mechanical stability. The Medicinal wafers should also be stored safely.

A second task is to provide such dosage forms with a easy and simple and virtually flawless production process so that it can be produced inexpensively, so that the dosage form the user (s) the safe and flawless Guaranteed intake of wafers. An inexpensive Preparation of the dosage form also requires that a variety Such dosage forms can be produced in a short time.

Summary of the invention:

These and other objects are achieved by the claimed method of manufacture for piles of bags for storage and provision drug wafers serving pharmaceutical bags solved. Preferred embodiments of the invention are in the Subclaims specified.

typically, there is a drug bag for the drug wafers from a base film and a cover sheet. The cover sheet can over a preferably along the side edges of the cover sheet extending strip-shaped connection connected to the base film, for example, glued or welded, be, or vice versa. Furthermore, the base film and the cover sheet in a particularly preferred embodiment of each at least one Side edge each have protruding tabs, the are not connected. This will be a pulling apart and thereby opening the drug bag for removal of the Wafers contained therein are much easier, because the two films can be easily grasped. A drug wafer is between the base film and the cover sheet within a through the compound formed area preferably air and moisture-proof locked in.

The to be produced by the method according to the invention Device for storing and providing the drug wafers contains the medicine bags containing the drug wafers in the form of a bag stack. To give control to a user to allow, whether in a certain period of time already a drug wafer has been taken or is still being taken must, in particular, be parallel to an edge of the medicine bags be arranged in the device times. Further, on everyone the medicine bags have a mark so attached to attached in the stack of bags successive drug pockets Markings are aligned with consecutive times and that optionally a drug bag with a on a first end of the marker edge marker a drug pouch with one at a second end of the Marking marker follows. This last one Case applies when there are a number of drug bags located in the pocket stack which is larger as the number of marker sections on each drug pocket, so that the sequence of in the marker sections on each other following marks in the pocket stack repeated. The marks thus follow on in the bag stack consecutive drug bags on each other, although if a medicine bag has a mark in the last marking portion, the following drug pocket mark again in the first Marking section has. Subsequent medicine bags in the bag stack then mark again in succession following marking sections.

to secure self-control by the user (s) are aligned arranged on the marker edge marks after receiving the Pocket stack in the device for storage and provision the wafer according to the invention with times. Thereby It will allow the user to determine if a wafer has already been taken or not in a certain period of time.

However, this bag pile must be produced flawlessly. Namely, if in the stack a single drug bag is missing or a drug bag is duplicated, so that consequently a mark in a certain marking portion in the sequence of drug pockets in the bag stack is missing or duplicated, the user will (in) misguided, and it can lead to misappropriation, ie, the user forgets to take a wafer, or takes a wafer twice within a take period. Therefore, the manufacturing process for the bag pile run flawlessly so that pocket stacks are produced in which the drug pockets with the markers are stacked on each other so that the markings of successive drug pockets in the stack are also in successive marker sections or optionally a drug pocket with one at a first end mark on a drug pocket with a marker located at a second end of the marker edge.

About that In addition, it must be ensured that the bag stacks with high production efficiency, d. H. u. a. with a high clock rate, can be produced.

For this reason, the following production method for the pocket stacks according to the invention is provided for achieving the stated object:
Stacking the drug pockets together to form at least one pocket stack so that in the at least one pocket stack there are successive drug pockets whose markers are in successive marker portions and optionally a drug pocket having a marker located at a first end of the marker margin on a drug pocket followed by a marker located at a second end of the marker edge.

So far in this case as well as otherwise in the present application the Mentioned on stacking drug bags is, among them is the stacking up of medicine bags meant, d. H. for example, one stacked on a stack Drug bag is placed on the stack.

With the provision of markings on one marking edge at a time on the medicine bags will ensure that the / Users (in each case) can control whether a wafer in a given Intake period has already been taken or not. this happens by checking if the mark is the one above Drug bag with a time field aligned with the current Period corresponds.

• a) Aufeinander-Stapeln der Arzneimitteltaschen unter Bildung mindestens eines ersten Teilstapels in einer ersten Herstellungsvorrichtung, so dass in jedem ersten Teilstapel Arzneimitteltaschen aufeinander folgen, deren Markierungen sich in aufeinander folgenden Markierungsabschnitten befinden, und gegebenenfalls eine Arzneimitteltasche mit einer sich an einem ersten Ende des Markierungsrandes befindenden Markierung auf eine Arzneimitteltasche mit einer sich an einem zweiten Ende des Markierungsrandes befindenden Markierung folgt;
• b) Aufstapeln weiterer Arzneimitteltaschen auf den mindestens einen ersten Teilstapel in einer zweiten Herstellungsvorrichtung, so dass in jedem so gebildeten Teilstapel Arzneimitteltaschen aufeinander folgen, deren Markierungen sich in aufeinander folgenden Markierungsabschnitten befinden, und gegebenenfalls eine Arzneimitteltasche mit einer sich an einem ersten Ende des Markierungsrandes befindenden Markierung auf eine Arzneimitteltasche mit einer sich an einem zweiten Ende des Markierungsrandes befindenden Markierung folgt;
• c) gegebenenfalls mindestens einmaliges Wiederholen von Verfahrensschritt b) durch jeweiliges Aufstapeln weiterer Arzneimitteltaschen auf den in der zweiten oder in einer weiteren Herstellungsvorrichtung erzeugten mindestens einen Teilstapel in weiteren Herstellungsvorrichtungen unter Bildung schließlich mindestens eines Taschenstapels.

In a preferred first embodiment of the invention, the production method comprises the following method steps:

• a) stacking of the drug pockets to form at least a first sub-stack in a first manufacturing device, so that in each first sub-stack drug bags follow each other, the markings are in successive marker sections, and optionally a drug pocket with a at a first end of the marker edge label on a drug pocket with a label located at a second end of the tag edge;
• b) stacking further medicament pockets on the at least one first partial stack in a second manufacturing device, so that in each partial stack thus formed drug pockets follow each other, the markings are in successive marker sections, and optionally a drug bag with a located at a first end of the marker edge Marking on a drug pocket with a label located at a second end of the marker margin;
• c) if necessary at least one repetition of method step b) by respectively stacking further medicament pockets on the at least one partial stack produced in the second or in another production device in further production devices to finally form at least one pocket stack.

By doing in this process variant, first in a first production device at least a first part of the stack is generated and on the at least a first sub-stack in other manufacturing devices more Pharmaceutical bags are stacked up, becomes a very efficient Manufacturing achieved, namely the fact that in the Storing additional drug pockets in the other manufacturing devices preferably again at the same time on the at least one first partial stack at least one next first partial stack in the first Manufacturing device can be produced. Thereby can the partial stacks are generated at the same time. The same applies to the case that with the piled up of medicine bags on the at least a first partial stack in the second manufacturing device not yet the at least one complete bag pile is produced, but first at least a second Partial stack is generated and even more medicine bags on this at least a second partial stack must be stacked. Then medicine bags are in a third Manufacturing device on the at least one second partial stack piled up. The resulting at least a third sub-stack or the resulting at least one complete one Pocket stacks are also preferably simultaneously with the generates at least a first and the at least one second sub-stack etc.

It is also advantageous that after generation of each sub-stack can be checked separately whether the Partial stack has been produced flawlessly. This makes it possible to remove a faulty partial stack before the completion of a complete stack of bags from the production process. This ensures that additional medicine bags are no longer stacked on an already faulty partial stack. This increases on the one hand the production capacity and reduces to the other committee.

Especially can each have a first sub-stack in a first manufacturing device by stacking drug bags, at least each a second and third sub-stacks in a second and third Manufacturing device by stacking additional drug pockets on each partial stack formed previously and at least one pocket stack in a fourth manufacturing device by stacking another Pharmaceutical bags are generated on every third sub-stack.

In a preferred embodiment of the invention the at least one generated in the first manufacturing device first part of the stack and the other in other manufacturing devices produced by piled up of other drug pockets Partial stack created at the same time, d. H. the further pile up of the Pharmaceutical bags on the at least one first partial stack in The other manufacturing devices happens simultaneously with generating the at least one first sub-stack in the first Manufacturing device, of course, the at least a first partial stack is first generated in the first manufacturing device must be before it is transported to the second manufacturing device so that there are more medicine bags under education at least a second sub-stack or at least one complete Stack of bags can be stacked. same for Of course, even in the event that in a third Manufacturing device more medicine bags on the at least a second sub-stack are stacked so that at least a third sub-stack simultaneously with the at least one first and second sub-stack can be generated. This sequence can be arbitrary be continued, namely by generating at least a fourth sub-stack or by generating at least one complete bag stack, generating at least one fifth sub-stack or generating at least one complete Pocket stack, etc.

• a) Aufeinander-Stapeln der Arzneimitteltaschen unter Bildung mindestens eines ersten Teilstapels in einer ersten Herstellungsvorrichtung sowie jeweils mindestens eines weiteren Teilstapels in weiteren Herstellungsvorrichtungen, so dass in jedem ersten und weiteren Teilstapel Arzneimitteltaschen aufeinander folgen, deren Markierungen sich in aufeinander folgenden Markierungsabschnitten befinden, und gegebenenfalls eine Arzneimitteltasche mit einer sich an einem ersten Ende des Markierungsrandes befindenden Markierung auf eine Arzneimitteltasche mit einer sich an einem zweiten Ende des Markierungsrandes befindenden Markierung folgt;
• b) Aufeinander-Stapeln des in Verfahrensschritt a) gebildeten mindestens einen ersten Teilstapels sowie der weiteren Teilstapel unter Bildung mindestens einen Taschenstapels, so dass in jedem Taschenstapel Arzneimitteltaschen aufeinander folgen, deren Markierungen sich in aufeinander folgenden Markierungsabschnitten befinden, und gegebenenfalls eine Arzneimitteltasche mit einer sich an einem ersten Ende des Markierungsrandes befindenden Markierung auf eine Arzneimitteltasche mit einer sich an einem zweiten Ende des Markierungsrandes befindenden Markierung folgt.

In a second variant of the invention, the method comprises the following method steps:

• a) stacking of the drug pockets to form at least a first sub-stack in a first manufacturing device and at least one further sub-stack in other manufacturing devices, so that in each first and subsequent sub-stack drug bags follow each other, the marks are in successive Markierungsabschnitten, and optionally a drug pocket having a marker located at a first end of the marker edge following a drug pocket with a label located at a second end of the marker edge;
• b) Stacking of the at least one first sub-stack formed in method step a) and the further sub-stack to form at least one pocket stack, so that in each pocket stack pharmaceutical bags follow one another, whose markings are in successive marker sections, and optionally a drug bag with a at a first end of the marker edge on a drug pocket with a marker located at a second end of the marker edge.

In This second variant of the invention are thus the in process step a) at least one formed in the first manufacturing device first part of stack and more in other manufacturing devices formed partial stacks (second, third, fourth partial stacks, etc.) under Formation of the bag stack stacked on top of each other, so that in the Pocket stack of drug bags follow each other, their marks are in consecutive marking sections, and optionally a drug pocket having a first end mark on a drug pocket with one located at a second end of the marker edge Mark follows.

In a preferred embodiment of this second embodiment The invention initially four sub-stacks are generated in each case and these four sub-stacks each forming a stack of bags then stacked on top of each other.

In a further preferred embodiment of this second Invention variant, the at least one in the first manufacturing device generated first part of the stack and the other in the other manufacturing devices generated partial stack generated simultaneously, d. H. the respective stacking on each other the drug pockets to form the at least a first Partial stack, the at least one second sub-stack, the at least one third sub-stack, the at least one fourth sub-stack, etc. happens simultaneously.

By initially in this embodiment at least one partial stack is produced, which then by stacking the respective sub-stack to the at least one pockets stack is summarized, if necessary, defective partial stacks can be removed from the manufacturing process in this case, before the entire bag stack is formed. This allows for a cost-effective production, because the amount of the Committee is minimized. On the other hand, the manufacturing process is thus also accelerated, because the drug pockets, which would otherwise have been taken up in the defective pocket stack, can thus be used to produce flawless bag stacks.

In a further preferred embodiment of both above Variants of the invention are at least two first part of stack Stacking of the medicine bags on each other simultaneously generates at least two second part stacks simultaneously, at least two third part stacks are generated at the same time, etc. (in the first embodiment of the invention with the exception the first partial stack by stacking medicine bags respectively on already formed partial stack and in the second embodiment the invention by separate successive stacking of the drug pockets, wherein the first, second, third part stacks, etc. then united by stacking on each other). For example six or twelve first partial stacks by stacking on top of each other the drug pockets generated simultaneously. This can be done in one suitable first production device by parallel extraction the medicine bags happen. These six generated at the same time or twelve first part stacks are then in a second Where converted as well at the same time six or twelve second partial stacks or already six or twelve pockets stack are generated. Or the six or twelve first partial stacks are according to the second embodiment in the second manufacturing device combined with six or twelve second part stacks. These sequences can be continued arbitrarily, such as the six or twelve second partial stacks in the first variant of the invention transferred to a third manufacturing device and by there by simultaneously stacking more medicine bags on the six or twelve second partial stacks six or twelve third partial stacks or already six or twelve Pocket stacks are generated or by the six or twelve second sub-stack in the second variant of the invention then in the third manufacturing device associated with the third sub-stacks become.

By this approach becomes a very efficient and fast way of production created because in each of the manufacturing devices several partial stacks be generated simultaneously. Under a simultaneous stacking However, this is not the case for the two process variants just to understand that the medicine bags to form the respective sub-stacks in synchronism, d. H. as it were "im same clock or "synchronous", stacked on top of each other become. Under the simultaneous stacking is also to be understood that the respective partial stacks are generated at about the same time. The bag stacks can be produced very fast in this way become. However, synchronous stacking is in this case prefers. The respective manufacturing device are for this purpose fed several drug bags at the same time, and these simultaneously supplied drug bags are then stacked on top of each other in synchronism with the sub-stacks.

In a further preferred embodiment of the invention concerning both variants of the invention, the medicine bags for producing the partial stacks stacked in each case in a cassette stacked on each other. For this purpose, at least one cassette is preferably provided, in who put the medicine bags and then stacked on each other become. For example, six or twelve Cassette be provided, for example, in a row or are also arranged in a carousel.

The Cassettes may continue to be movable, for example around the part stacks produced in the cassettes to another manufacturing device in which each partial stack according to the second embodiment of the invention with another Partial stack is united by the further part of the stack on the first sub-stack is placed in the cassette.

alternative The cassettes can also be moved to this a second manufacturing device, in the other medicine bags according to the first Embodiment of the invention on the first sub-stack be stacked up. For example, the first sub-stack by seven Be formed drug pockets. In the second manufacturing device can then also seven medicine bags on the stacked first partial stack. After that, he can do it now 14 drug pockets containing second partial stack into a third Are conveyed in the manufacturing apparatus, in the example another seven medicine bags are stacked on the second part stack. Thereafter, the so-now containing 21 medicine bags third partial stacks transported in a fourth manufacturing device in which, for example, another seven medicine bags be stacked on the third sub-stack. This method can in principle with any number of drug pockets in each of the manufacturing devices and with any number be performed on manufacturing devices. For example You can use it to produce bag stacks of 28 medicine bags become.

If the wafers for hormone replacement therapy contained in the medicine bags typically, the bag stacks typically contain 28 drug pockets. The 28 medicine bags can either - at a single-phase preparation - 28 same drug wafers or - for contraception in a two-phase Preparation - also 24 identical drug wafers and four more drug wafers with one placebo or another Medicines or also - also in a biphasic Specimen - 21 same drug wafers and seven additional drug wafers with a placebo or other medicine contain. In case of biphasic preparations need the medicine bags containing the the placebo or other medicines containing wafers at the beginning or at the end of the bag stack be inserted. For this purpose, either to Start in a separate manufacturing device the drug bags put together to a stack that the placebo or contain the other drug-containing wafer, or at the end the stacking process in a separate manufacturing device piled up the already produced partial stack.

In further embodiments of the invention can the bag stacks, for example, also for use for contraception also a different number of medicine bags contained as 28, namely, for example, 30 medicine bags. In In this case, in each manufacturing device, respectively ten medicine bags to the already existing partial stacks be added (or stacked on top of each other, to create the first sub-stack), or seven each Medicine bags and finally two medicine bags in another manufacturing device.

In Still another embodiment of the invention can the wafers in case of use for contraception also used for a so-called flexible revenue regime where the wafers are flexible during a first Taken at least 24 days and at most It lasts 120 days and is the first flexible intake phase followed by a four-day interruption, for example. In this case, the bag stack can also be 28 or also 56 or even 84 or even 112 or 120 medicine bags or also include any other number. The pattern for stacking on each other the medicine bags according to the present Invention is directed in this case in a corresponding manner and In each case according to the number of located in the bag stack Medicament pockets.

In a preferred embodiment of the invention can There are seven marking sections at the marking edge of each drug bag. These marker sections each with a marker in one For example, the tagging sections may be the days of the week correspond. In the assembled storage device and providing the drug wafers may be the tag sections are aligned with corresponding times, such as weekdays, so that a marker in a marker section on a Drug bag, which rests in the bag stack on top, with a certain day of the week is aligned, for example with "Mo" for Monday, and to indicate to the user on which day the wafer is in this medicine bag must be taken, d. H. in the present Fall on Monday.

alternative For example, three marking sections, according to three times of the day (morning, noon, evening), or also a different number of marking sections are provided, the the respective requirements of frequency of taking equivalent.

Farther For example, each of seven medicine bags forming at least a first sub-stack stacked on each other become. In the first embodiment of the invention then each additional seven medicine bags on the at least a first partial stack, each further seven medicine bags piled up on the at least one second partial stack, etc. In the second embodiment of the invention are additionally produces second, third partial stacks, etc., for the first partial stacks, each containing seven medicine bags. The respective partial stacks are then stacked on top of each other.

These Approach can be particularly advantageous if the Drug bags seven marker sections, according to the seven Weekdays. In this case, the medicine bags in the sub-stack preferred for taking the wafer during serve one week if one wafer per day is taken.

In a further preferred embodiment of the first variant of the invention the bag pile is produced in four manufacturing devices, in each case for each stack of bags each seven medicine bags be stacked up. In the second variant of the invention are by respective stacking of drug pockets to form a Pocket stack four partial stacks generated and then combined. If the wafers are taken each once a day and each one There are seven medicine bags in a sub-stack are in the Pocket stack of 28 wafers combined, taken in 28 days become.

In a further preferred embodiment of the invention The medicine bags are separated by a single sheet generated. As a bow is in the present sense a preferably rectangular to understand a foil-like structure. The bow is preferably made various materials layered together and includes, for example, plastic films, aluminum foils, paper o. Ä. Under a bow is also a band to understand, d. H. a long time elongated sheet, for example, on a roll (coil) wound up is.

One Sheet is for singling preferably to the individual production devices introduced and placed under a singulator. There are the individual drug bags from the bow preferably at the same time isolated. Preferably, the separation material (drug pockets and separation residues) then transported to a take-off place. From there, the medicine bags are successively, for example by means of Removed robot arms. The robot arms can with a equipped with special sensors to verify that Each medicine bag gripped, transported and into the cassettes has been filed.

Preferably The medicine bags are separated from the sheet by punching. This is a cost-effective and precise separation technique. Other separation techniques are also conceivable, for example To cut.

In a further preferred embodiment of the invention the sheet contains the appropriate drug bags Fields with one drug wafer each and one each Marking in the respective marking sections at respective field edges in a matrix-like arrangement. In the sheet are the drug wafers hermetically sealed by welding. In addition, you can are on the sheet except the markings imprints, for example, allow identification of the drug. The sheet preferably contains at least four and at most twelve Rows of fields. For example, four, eight, ten or twelve rows of fields. Each of the For example, rows contain seven or fourteen fields.

In a further preferred embodiment of the invention follow fields whose marks are consecutive Marking sections are located in a respective row on the bow each other. This allows the drug pockets in the logical order can be taken from the arc in the they are also stacked in the sub-stack. Several adjacent rows preferably have fields that are too The adjacent fields of the other rows are identical. Fields of several rows are separated into medicine bags, which are then fed to different sub-stacks.

In a further preferred embodiment of the invention The medicine bags are used to produce a respective first Partial stack stacked on a support each other. This enables a particularly secure production method: The Drug bags are for use by the / User preferably held in a carrier. Thereby On the one hand, the required stability is achieved also the drug wafers against mechanical impairment on the other hand, that the times, the to control the regular intake by the User (in) serve, can be mounted on the support. By means of the carrier, the drug pockets also be summarized and held in the bag stack. By the drug pockets of the first sub-stack already on the Carriers can be piled up, these can be lighter summarized and held. It eliminates an otherwise Required transport process of the finished bag stack to the carrier to the stack together with the carrier to be able to fix.

In a further preferred embodiment of the invention the wearer has at least one of the medicine bags on the carrier holding the connecting element. Concerning the first embodiment of the invention can additional medicine bags piled up on the first part stack so that the other medicine bags also from the Be held connecting element. Regarding the second embodiment Furthermore, the invention can be any further partial stack, i. H. of the second, third, fourth partial stacks, etc., on the first partial stack be stacked such that contained in the other sub-stacks Pharmaceutical bags also held by the connecting element become. This procedure becomes an instant fixation reaches the individual drug pockets, allowing a disassembly a sub-stack or the finished bag stack, for example in a transport process can not take place.

In a further embodiment of the invention, the Carrier also has a guide element for guiding the medicine bags on the carrier. This will achieved that the drug pockets on the carrier in the Essentially edge-to-edge stacked on each other and also in the Can stay the following.

For the production of the bag stack, it is advantageous if the medicine bags in Kasset th and stacked on top of each other. When using a carrier, it is first placed in the respective cassette so that the drug pockets can be placed thereon.

The Times are preferably so mounted on the support, that they are with the marker sections on the medicine bags are aligned when the drug pockets are combined with the carrier are.

In a preferred embodiment of the invention, the Pocket stack also exclusively by means of a connecting element be summarized without a carrier is used. In this case, the medicine bags with the Connecting element instead of being connected to the carrier, when stacked in the first manufacturing device become. In addition, in this case, a guide element used to edge the drug bags to each other stack and hold together. The means of the connecting element held together can be interchangeable on one Carrier to be attached. For example, the carrier be designed so that a stack of bags are easily attached to him can. This makes it possible to use the pocket stack in the Carrier interchangeable and the carrier with the bag stack make it refillable. this makes possible an elaborate design of the carrier, since this after the consumption of the wafer is not thrown away but reused.

The Connecting element, for example, a rivet or another Be fastener that tamper-proof the bag stack holds together. The connecting element connects the medicament pockets with each other so that they are preferably arranged movable relative to each other are. In the case of a rivet, the connecting element from each two, for example, rod-shaped connecting element parts, which nestled or screwed or glued together can exist. The connecting element can also be rod-shaped be. In a further embodiment of the invention the connecting element also formed in a compact design in which it consists of two parts, being then when it is composed is, the openings in the drug pockets almost completely can fill. The connecting element can in particular a box-shaped lower part with a web arranged therein to pass through the openings and a box-shaped Lower part include closing top. Furthermore, can the box-shaped lower part of the box-shaped Connecting element a base plate, a seated on the base plate and the medicine bags partially enclosing and thus include the leading wall and the bridge. As a connecting element In any case, a component is to be understood through the openings is guided in the drug pockets and the Medical bags connects. Thus, a rivet and also the web of the formed in the compact design connector be understood as connecting elements. In the case of the bridge needs it is of course additional to keeping the pile together suitable holding devices at the foot and the head of the bridge. These additional holding devices can, for example through the box construction, consisting of the kas tenförmigen Lower part and the upper part, be realized. Alternatively you can at the foot and at the head of the bridge also differently designed feet and head portions are provided which hold the stack together. Of the The bridge can also be designed as a rivet with two ridge-shaped rivet heads be. When assembling the at least one connecting element forming connecting element parts can lock them together and preferably are not non-destructible from each other again detachable, or they can be glued together, welded or with another joining technique be connected to each other. In all these cases it acts it is a so-called tamper-evident closure, d. H. a tamper evident closure. Especially preferred it is when the connection of the at least two parts that the connecting element form, is achieved by positive engagement. Under a rivet is a To understand connecting element, which consists of at least two parts exists, which interlock and thereby form-fitting be connected to each other, and further by appropriate Head formations is capable of the interposed stack off Staple medicine bags together.

Of the Carrier is preferably made of cardboard, plastic or metal produced. Preferably, the carrier encloses the bag stack to protect the individual medicine bags. For this purpose, the carrier may be formed as an elongated strip, which is folded around the pocket pile around. For example, can a front tab protruding from one side of the strip be designed as a lid. Furthermore, for example, an on the other side of the strip protruding tab as a cover be educated. For example, the cover and the lid be equipped with suitable closure means to the wearer to complete the pile of bags, such as Velcro, Pressure, magnetic, plug-in, rubber band closure.

The Times can be on the carrier or on the Attached connecting element.

The device produced by the method according to the invention is preferably counterfeit safely executed. For this purpose, one or more security features are provided on the device, which allow verification of the authenticity of the device, for example, imprints in micro-writing, holograms, tilt images or other security features.

The Figures described below are for general understanding the invention. But they are not meant to be limiting but are only intended to explain certain embodiments, which are preferred without other preferred embodiments excluded.

1 shows a schematic representation of the process sequence of the method according to the invention;

2 shows the layout of a sheet from which drug pockets are obtained by punching; 2a : Variant of the bow of 2 ;

3 shows a first embodiment of a wafer pocket booklet containing a pocket stack produced by the method according to the invention in various assembly stages in a perspective view; 3a : Pocket stack and fastener; 3b : Wafer pocketbook open; 3c : Wafer pocketbook closed; 3d : Wafer pocketbook in side view; 3e : alternative embodiment with rubber band for closing the wafer pocket booklet; 3f : alternative embodiment with tab for closing the wafer pocket booklet; 3g : alternative embodiment with magnetic closure;

4 shows a second embodiment of a wafer pocket booklet containing a pocket stack produced by the method according to the invention in various assembly stages in a perspective view; 4a : Carrier; 4b-1 : Pocket stack and connecting element with guide each individually; 4b-2 : as 4b-1 assembled; 4c : Wafer pocketbook open; 4d : Wafer pocketbook closed;

5 shows a third embodiment of a wafer pocket booklet containing a pocket stack produced by the method according to the invention in various assembly stages in a perspective view; 5a : Beam with connecting element and guide; 5b . 5c : Wafer pocketbook completely or partially opened; 5d : Wafer pocketbook closed; 5e : as 5a with different arrangement of the weekday strip;

6 shows a fourth embodiment of a wafer pocket booklet containing a pocket stack produced by the method according to the invention in a side view.

Like reference numerals in the figures indicate the same Elements.

In 1 the process sequence according to the invention is shown schematically. The elements shown may be for devices that can be used ver for carrying out the method. However, other configurations of the devices used can be used, provided they meet the purposes of the invention.

The sheets containing the medicine bags in the form of fields 1 become punching devices 20 . 20 ' in modules 10 . 10 ' . 10 '' fed. The number of modules depends on the total number of drug pockets T to be accommodated in a pocket stack, as well as the number of drug bag fields contained in a sheet in a row, ie, the number of drug pockets supplied to each module. For example, if a total of 28 medicine bags are to be packaged in a bag stack and there are seven drug pockets in a row on a sheet, four modules must be provided.

In 2 is an example of a layout of an arc 1 with a total of 6 × 7 = 42 medicine bags on as many fields 2 shown. The fields are arranged in rows R and columns S. In the present case, six rows and seven columns are provided. The rows and columns are in 2 exemplified by arrows. The fields in a row on an arc are assigned to a stack. Fields of different series can be assigned to different stacks.

In the fields 2 are each field areas 3 for openings and marking sections 4 recognizable at a marking edge of the respective field. Within the marker sections are marks 5 applied, for example by a printing process, to facilitate the user's control of the regular intake. It can be seen that the position of the marks at the marking edge are the same in different rows but equal columns, while the position of the marks in successive fields in a row follow each other: viewed from below, the marks are in the lowest, second lowest, third lowest marking portion etc. placed.

A variant of the drug pocket template of 2 is in 2a shown. This template 1 differs from that described above in that eight rows of each seven fields are provided for the preparation of drug pockets. Furthermore, each field has an oval opening 3 as well as a perforation 153 as well as notches 152 on. In addition, the template is on both sides 1 protruding edges 6 , in which there are continuous perforations 7 are located. These perforations 7 serve to transport the template 1 , like a film transport.

Each of the modules 10 . 10 ' . 10 '' become two such arches 1 supplied (see arrows in 1 ). The areas on the sheets corresponding to the individual rows R and columns S are in 1 also shown schematically.

The bows 1 be simultaneously on the punching tables 21 . 21 ' the punching equipment 20 . 20 ' placed. There are the drug pockets T corresponding to the field border in 2 punched out. At the same time also the openings 3 formed by punching. The punching tables can be moved in parallel according to the arrows. As a result, a sheet can be arranged under the punching device before punching and after punching out the medicament pockets from the punching area (in FIG 1 to the top). Thus, it is possible that another sheet is already placed on the punching table, while still the punched out drug pockets and finally the punching residue are removed from the punching table successively. The punching process takes place in the front area of the table (in 1 in the lower area), on which the sheet for punching is first deposited and fixed, for example by vacuum application. After punching, the punching tables are moved backward (away from the sheet supply) so that the punched-out drug pockets can be removed from the punching table.

Special robot arms (not shown) which are equipped with a sensor system are used to remove the individual drug pockets T, in order to ensure that the individually received drug pockets are safely picked up, safely transported and safely deposited again. With the robot arms the medicine bags are in cassettes 25 . 25 ' . 25 '' . 25 ''' , ... filed. The cartridges contain carriers for the stack of pouches containing rivets or other fasteners prior to loading a first drug pouch. The drug pockets are placed on the carrier so that the rivets pass through the aperture 3 be passed. As a result, the medicine bags are held and additionally guided. Even with improper handling of the formed stack of bags they can then no longer fall apart easily.

In the modules 10 . 10 ' . 10 '' There are twelve cassettes each. Therefore, each module can have two sheets 1 fed simultaneously, since each sheet contains six drug pocket rows R. The sheets fed to the individual modules 1 are punched simultaneously. In addition, the punched-out drug pockets T of a given column S in each module are simultaneously placed in the cassettes.

After all the drug pockets T of the bows 1 in the modules 10 . 10 ' . 10 '' in the appropriate cassettes 25 . 25 ' . 25 '' . 25 ''' , ... have been promoted there, partial stacks have emerged. In the present case, each first sub-stack contains in the first module 10 seven medicine bags. In the second module 10 ' already second partial stacks have been created by stacking seven medicine bags on the first part of the stack. Thus, the second partial stacks already contain 14 medicine bags, etc.

After completion of the partial stack all cassettes 25 . 25 ' . 25 '' . 25 ''' , ... the modules 10 . 10 ' . 10 '' simultaneously moved to the right. Thus then get the cassettes of the first module 10 to the second module 10 ' , the cassettes of the second module 10 ' to the third module, etc.

After moving the cassettes 25 . 25 ' . 25 '' . 25 '' , ... of a module 10 . 10 ' . 10 '' The module to the right next to it will again be made of arches 1 stamped out drug pockets T in the cassettes 25 . 25 ' . 25 '' . 25 ''' , ... the modules 10 . 10 ' . 10 '' placed. Thus, in the first module 10 in turn, first partial stacks formed from drug pockets. In the other modules 10 ' . 10 '' be added to the already existing sub-stacks more drug pockets, so that in the present case in the second module 10 ' Partial stack with 14 , in the third module partial stack with 21 and in the fourth module 10 '' a stack of bags with 28 drug pockets are formed.

After completion of the stack of bags in the fourth module 10 '' these are removed, the rivet connection to the bag stacks are closed, and the carrier strips are folded over to protect the bag stacks.

In 3 is a first embodiment of a pocket stack produced by the method according to the invention 100 containing wafer pocket booklet shown in perspective view.

The bag pile 100 includes a variety of drug pockets, such as 28 bags, of which only the top pharmaceutical bag 110 is visible. The drug pocket contains a shrink-wrapped wafer 120 , At the lower edge 130 . which is a marker edge, there are marker sections 140 , There is a mark on one of the marking sections 141 , In the second drug pocket (not visible) underlying the upper visible drug pocket, this mark is affixed to the marker portion, which is adjacent to the first marker portion where the mark is on the uppermost drug pocket.

The medicine bags 110 are included in the upper area 151 . 152 notched on two sides and have a perforation 153 on. The notch serves to assist in tearing off the wafer 120 containing lower portion of the overhead drug pocket. In addition, the medicine bags have long holes 160 on, by in the assembled state of the booklet the rivet 200 reaches through.

Above the bag pile 100 is the two-piece rivet 200 shown: The rivet has a lower part 210 and a top 220 on. The lower part reaches from below through the slots 160 therethrough. The columnar rivet holders 211 . 212 are on a base plate 213 fastened so spaced apart that the outer edges of the rivet holders loosely abut the rounded slot ends. These outer edges are slightly tilted towards the top, so that the successively placed on the rivet base medicine bags with their respective slot easily slip on the rivet (enlarged view of the rivet holder 212 ). After the entire stack of pockets has been formed, the rivet is closed by pressing the rivet shell between the columnar rivet holders. For the positive connection of the Nietoberteils with the Nietunterteil both rivet parts have tooth-shaped side surfaces which dig into each other. After the rivet is closed, the stack of piles can be easily handled without the fear of compromising the integrity of the stack during handling. In addition, the riveted pocket stack can also be used to refill a carrier. In 3d it is shown that the rivet is made so long that the drug pockets have perpendicular play on it. As a result, the difference in thickness of the wafer pocket areas on the pockets can be taken into account with respect to the remaining areas. The medicine bags also slide frictionless on the rivet.

The rivet base 210 is preferably on a carrier strip 300 attached. When creating the first sub-stack of drug bags 110 Preferably, the carrier strips with the rivet lower part first into the cassettes 25 . 25 ' . 25 '' . 25 ''' , ... ( 1 ). The drug pockets are then placed on this strip, with the attached to the carrier strip rivet base each in the slot 160 the pockets slides in and the pockets leads to one, ie determines their position and this holds to the other also.

After stacking all of the drug pockets of a wafer pocket booklet, the carrier strip will become a weekday strip 310 Mistake. The weekday strip is attached so that it matches the marker sections 140 on the medicine bags 110 flees. This allows the user to recognize on which day of the week the wafer 120 the overhead medicine bag 110 must be taken.

The carrier strip 300 is then folded at both the upper end and at the lower end so that the upper end of a cover 320 for the wafer pocketbook. For example, the cover may contain information about the manufacturer and the name of the medicine. The cover extends substantially over the entire area of the drug pockets 110 , It is after folding by pressing the Nietoberteils 220 between the columnar rivet holders 211 . 212 of the rivet lower part 210 fixed.

The lower end of the carrier strip 300 is also folded over so that it has a lid 330 for the medicine bags 110 forms. The closed state of the wafer pocket booklet is in 3c recognizable. The lid 330 reaches over the cover 320 , Both parts are connected by a releasable closure. For example, on the inside of the lid and on the outside of the cover hook and loop fasteners 410 . 420 to be appropriate. The Velcro closures are in 3d shown. A magnetic closure is in 3g shown. This is in the edge of the lid 330 For example, a metal strip preferably applied over the entire width of the lid, and on the edge region of the cover 320 For example, a magnetized metal strip is also preferably applied over the entire width of the cover.

An alternative embodiment of the wafer pocket booklet is in 3e Shown: Instead of the Velcro or the magnetic closure is a rubber band 430 provided on the lower part of the carrier 300 is attached and to close the booklet over the cover 320 is pulled.

Another embodiment of the wafer pocket booklet is in 3f shown. In this case is on the cover 320 a formed by punching and bent down tab 440 provided in a slot 450 in the lid 330 can intervene when the wafer pocket booklet is closed.

In 4 is a second embodiment of a bag stack produced by the method according to the invention 100 shown wafer pocket booklet in various assembly stages shown in perspective view.

The bag pile 100 includes a variety of drug bags 110 For example, 28 bags, of which only the uppermost drug bag is visible. The drug pocket contains a shrink-wrapped wafer 120 , At the lower edge 130 , which is a marker edge, are marker sections 140 , There is a mark on one of the marking sections 141 , In the second drug pocket (not visible) underlying the upper visible drug pocket, this mark is affixed to the marker portion, which is adjacent to the first marker portion where the mark is on the uppermost drug pocket.

The medicine bags 110 are included in the upper area 151 . 152 notched on two sides and have a perforation 153 on. In addition, the medicine bags have long holes 160 on, by in the assembled state of the booklet a bridge 214 reaches through.

In 4b-1 is above the bag stack 100 the fastening device 200 shown, which is constructed in two parts: The fastening device has a lower part 210 and a top 220 on. The lower part includes a bridge 214 as well as a frame 215 both on a base plate 213 are attached. The bridge reaches from below through the slots 160 therethrough. The frame 215 partially limits the base plate on three sides as well as on the fourth side. Where this frame is not located, the drug pockets may extend over the perforation-containing connector. Incidentally, this frame surrounds the upper part of the drug pockets flush and thus represents an external guide for the drug pockets so that they sit tight in the wafer pocket booklet without play. The upper part of the fastening device is through a plate 220 formed, which can be positively or cohesively fastened on the lower part. In cohesive connection, the plate can be connected, for example by means of ultrasonic welding with the lower part. For a positive connection, for example undercuts on one of the two parts and projecting parts are provided on the other of the two parts.

After the fastening device 200 is closed, the bag pile can 100 be handled without fear that the integrity of the stack could be compromised in handling.

The lower part 210 the fastening device 200 is preferably on a carrier strip 300 , For example, by gluing, attached. When creating the first sub-stack of drug bags 110 The carrier strip with the lower part are preferably first in the cassettes 25 . 25 ' . 25 '' . 25 ''' , ... ( 1 ). The drug pockets are then placed on this strip, with the bridge 214 of the lower part attached to the carrier strip in each case in the slot 160 the pockets slides in. Through this bridge as well as the frame 215 the drug pockets are held on the carrier strip. In addition, their position is determined exactly.

After stacking all the drug pockets of a wafer pocket booklet together, the carrier strip becomes 300 with a weekday strip 310 Mistake. The weekday strip is attached so that it matches the marker sections 140 on the medicine bags 110 flees. As a result, the user can recognize on which day of the week the wafer of the overhead medicament bag must be taken.

The carrier strip 300 is then folded so both at the bottom so that this end a lid 330 for the wafer booklet. For example, information about the manufacturer and the name of the medicine may be appropriate on the lid. The lid extends substantially over the entire surface of the drug pockets.

The top of the carrier strip 300 will not be folded over. At this point forms the fastening device 200 a box that closes the wafer pocket booklet at the top. The closed state of the wafer pocket booklet is in 4d recognizable. The lid 330 extends over the fastening device. Both parts are connected via a detachable closure. For example, can be attached to the inside of the lid and on the outside of the fastening device magnetic fasteners. The partial elements of the magnetic closure can be hidden in the respective components.

In 5 is a third embodiment of a pocket stack produced by the method according to the invention 100 shown wafer pocket booklet in various assembly stages shown in perspective view.

The bag pile 100 includes a variety of drug pockets, such as 28 bags, of which only the top pharmaceutical bag 110 is visible. The drug pocket contains a shrink-wrapped wafer 120 , At the lower edge 130 , which is a marker edge, are marker sections 140 , On one of the markers sections there is a marker 141 , In the second drug pocket (not visible) underlying the upper visible drug pocket, this mark is affixed to the marker portion, which is adjacent to the first marker portion where the mark is on the uppermost drug pocket.

The medicine bags 110 are included in the upper area 151 . 152 notched on two sides and have a perforation 153 on. In addition, the medicine bags have long holes 160 on, by in the assembled state of the booklet a bridge 214 round picks.

In 5a is the attachment device 200 on the carrier strip 300 shown. The fastening device is constructed in two parts: It has a lower part 210 and a top 220 on. The lower part includes a bridge 214 a frame 215 as well as a base plate 213 , The bridge reaches from below through the slots 160 therethrough. The frame 215 sits on the edge of the base plate 213 on. It partially limits the base plate on three sides as well as on the fourth side. Where this frame is not located, the medicine bags 110 pass through the connecting part having the perforation. Incidentally, this frame surrounds the upper part of the drug pockets flush and therefore leads them so that they sit tightly in the wafer pocket booklet without play. The upper part of the attachment is through the plate 220 formed, which can be positively or cohesively fastened on the lower part.

The lower part 210 the fastening device 200 is on the carrier strip 300 attached for example by gluing. When creating the first sub-stack of drug bags 110 become the carrier strips with the lower part 210 preferably first in the cassettes 25 . 25 ' . 25 '' . 25 ''' , ... ( 1 ). The drug pockets are then placed on this strip, with the bridge 214 of the lower part of the fastening device fastened on the carrier strip in each case into the oblong hole 160 the pockets slides in. Through this bridge as well as the frame 215 the drug pockets are held on the carrier strip. In addition, their position is determined exactly.

After stacking all drug bags together 110 of a wafer pocket booklet becomes the carrier strip 300 with a weekday strip 310 Mistake. The weekday strip can be found both at the in 5a as well as at the in 5e be shown attached position. The weekday strip is attached so that it matches the marker sections 140 on the medicine bags 110 flees. As a result, the user can recognize on which day of the week the wafer of the overhead medicament bag must be taken.

The carrier strip 300 is then folded over at the top so that the end is a cover 320 for the wafer pocketbook. For example, the cover may contain information about the manufacturer and the name of the medicine. The cover extends over the entire surface of the drug pockets 110 and over the supernatant of the wearer at the bottom of the booklet.

The lower end of the carrier strip 300 is folded so that the block 340 results. The cover 320 grabs the block. Both parts are connected by a releasable closure. For example, magnetic closures may be attached to the inside of the cover and to the outside of the block.

In 6 a fourth embodiment of the wafer pocket booklet is shown. As in the case of the booklet of 4 is the lid 330 of the carrier 300 from below over the bag pile 100 pulled and covers it in the closed state. In contrast to the embodiment of 4 is a rivet as a connecting element 200 used. This diet, together with a corresponding opening in the lid, serves as a closure for the wafer pocket booklet by inserting a protruding part of the rivet into a hole in the lid.

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Cited patent literature

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Claims (18)

Method for producing pocket stacks ( 100 ) for the storage and provision of drug wafers ( 120 ) serving pharmaceutical bags (T, 110 ), each drug pocket (T, 110 ) at a marker edge ( 130 ) a mark ( 141 ) in one of a plurality of adjacent marking sections ( 140 ), the method comprising the following step: Stacking of the drug pockets (T, 110 ) forming at least one pocket stack ( 100 ), so that in the at least one pocket stack ( 100 ) Medicine bags (T, 110 ), whose marks ( 141 ) in successive marking sections ( 140 ), and optionally a drug bag (T, 110 ) at a first end of the marker edge ( 130 ) ( 141 ) on a drug pocket (T, 110 ) with a at a second end of the marker edge ( 130 ) ( 141 ) follows. A method according to claim 1, characterized in that the method comprises the following method steps: a) stacking of the drug pockets (T, 110 ) forming at least a first sub-stack in a first manufacturing device ( 10 ), so that in each first partial stack drug pockets (T, 110 ), whose marks ( 141 ) in successive marking sections ( 140 ), and optionally a drug bag (T, 110 ) at a first end of the marker edge ( 130 ) ( 141 ) on a drug pocket (T, 110 ) with a at a second end of the marker edge ( 130 ) ( 141 ) follows; b) stacking up further medicament pockets (T, 110 ) on the at least one first partial stack in a second production device ( 10 ' ), so that in each sub-stack thus formed, drug pockets (T, 110 ), whose marks ( 141 ) in successive marking sections ( 140 ), and optionally a drug bag (T, 110 ) at a first end of the marker edge ( 130 ) ( 141 ) on a drug pocket (T, 110 ) with a at a second end of the marker edge ( 130 ) ( 141 ) follows; c) optionally repeating process step b) at least once by respectively stacking up further medicament pockets (T, 110 ) in the second or in another production device ( 10 ' ) produced at least one sub-stack in further production devices ( 10 '' ) finally forming at least one pocket stack ( 100 ). A method according to claim 2, characterized in that in each case a first partial stack in a first production device ( 10 ) by stacking drug pockets (T, 110 ), at least one second and third partial stack in a second and third production device ( 10 ' ) by stacking further medicament pockets (T, 110 ) on each previously formed partial stack and at least one pocket stack ( 100 ) in a fourth manufacturing device ( 10 '' ) by stacking further medicament pockets (T, 110 ) are generated on every third sub-stack. A method according to claim 1, characterized in that the method comprises the following method steps: a) stacking of the drug pockets (T, 110 ) forming at least a first sub-stack in a first manufacturing device ( 10 ) and in each case at least one further sub-stack in further production devices ( 10 ' . 10 '' ), so that in each first and further partial stack drug pockets (T, 110 ) whose marks ( 141 ) in successive marking sections ( 140 ), and optionally a drug bag (T, 110 ) at a first end of the marker edge ( 130 ) ( 141 ) on a drug pocket (T, 110 ) with a at a second end of the marker edge ( 130 ) ( 141 ) follows; b) stacking on one another of the at least one first sub-stack formed in method step a) and the further sub-stack to form at least one pocket stack ( 100 ), so that in each pocket stack ( 100 ) Medicine bags (T, 110 ) whose marks ( 141 ) in successive marking sections ( 140 ), and optionally a drug bag (T, 110 ) at a first end of the marker edge ( 130 ) ( 141 ) on a drug pocket (T, 110 ) with a at a second end of the marker edge ( 130 ) ( 141 ) follows. A method according to claim 4, characterized in that in each case four partial stacks with formation of a respective pocket stack ( 100 ) are stacked on top of each other. Method according to one of the preceding claims, characterized in that at the marking edge ( 130 ) of each drug bag (T, 110 ) seven marking sections ( 140 ) are located. Method according to one of the preceding claims, characterized in that in each case seven medicament pockets (T, 110 ) are stacked to form a first sub-stack. Method according to one of claims 2-7, characterized in that in each case at least two partial stacks by stacking the drug pockets (T, 110 ) are generated simultaneously. Method according to one of the preceding claims, characterized in that the medicament pockets (T, 110 ) for producing the partial stacks in each case in a cassette ( 25 . 25 ' . 25 '' . 25 ''' ) are stacked on top of each other. Method according to one of the preceding claims, characterized in that the medicament pockets (T, 110 ) by separating from a sheet ( 1 ) be generated. Method according to claim 10, characterized in that the medicament pockets (T, 110 ) by punching out of the sheet ( 1 ) be generated. Method according to one of claims 10 and 11, characterized in that the sheet ( 1 ) the drug pockets (T, 110 ) corresponding fields ( 2 ) each with a drug wafer ( 120 ) and each with a marker ( 141 ) in the respective marking sections ( 140 ) at respective field margins ( 130 ) in a matrix-like arrangement. Method according to claim 12, characterized in that fields ( 2 ), whose markings ( 141 ) in successive marking sections ( 140 ) are consecutive in a respective row (R). Method according to one of the preceding claims, characterized in that the medicament pockets (T, 110 ) for generating a respective first sub-stack on a respective carrier ( 300 ) are stacked on top of each other. Method according to claim 14, characterized in that the carrier ( 300 ) at least one of the drug pockets (T, 110 ) on the support ( 300 ) holding connection element ( 200 ) and that further medicament pockets (T, 110 ) or further partial stacks of medicament pockets (T, 110 ) are stacked on the first sub-stack, so that the further drug pockets (T, 110 ) or the drug pockets contained in the further sub-stacks (T, 110 ) also from the connecting element ( 200 ) being held. Method according to claim 15, characterized in that the carrier ( 300 ) a guide element ( 215 ) for guiding the medicament pockets (T, 110 ) on the support ( 300 ) having. Method according to one of claims 14-16, characterized in that on the support ( 300 ) Times ( 310 ), so that the dates ( 310 ) with the marking sections ( 140 ) are aligned. Method according to claim 17, characterized in that the times ( 310 ) Are weekdays.