CN103617761B - A kind of High-precision multi-tissue simulation fetal model - Google Patents
A kind of High-precision multi-tissue simulation fetal model Download PDFInfo
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- CN103617761B CN103617761B CN201310664607.5A CN201310664607A CN103617761B CN 103617761 B CN103617761 B CN 103617761B CN 201310664607 A CN201310664607 A CN 201310664607A CN 103617761 B CN103617761 B CN 103617761B
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- 230000001605 fetal effect Effects 0.000 title claims abstract description 45
- 238000004088 simulation Methods 0.000 title claims abstract description 14
- 210000003754 fetus Anatomy 0.000 claims abstract description 44
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 30
- 238000002360 preparation method Methods 0.000 claims abstract description 28
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 claims abstract description 20
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 19
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000741 silica gel Substances 0.000 claims abstract description 16
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 16
- CADZRPOVAQTAME-UHFFFAOYSA-L calcium;hydroxy phosphate Chemical compound [Ca+2].OOP([O-])([O-])=O CADZRPOVAQTAME-UHFFFAOYSA-L 0.000 claims abstract description 13
- 238000005516 engineering process Methods 0.000 claims abstract description 8
- 238000010146 3D printing Methods 0.000 claims abstract description 5
- 238000002591 computed tomography Methods 0.000 claims abstract description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 7
- 239000000499 gel Substances 0.000 claims description 7
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 210000004185 liver Anatomy 0.000 claims description 6
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 6
- 210000001519 tissue Anatomy 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 5
- 210000003734 kidney Anatomy 0.000 claims description 5
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- 210000003625 skull Anatomy 0.000 claims description 4
- 229910052582 BN Inorganic materials 0.000 claims description 3
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 claims description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000007469 bone scintigraphy Methods 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 3
- 210000004072 lung Anatomy 0.000 claims description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 3
- 239000011574 phosphorus Substances 0.000 claims description 3
- 229910052698 phosphorus Inorganic materials 0.000 claims description 3
- 239000004584 polyacrylic acid Substances 0.000 claims description 3
- 238000007639 printing Methods 0.000 claims description 3
- 239000002002 slurry Substances 0.000 claims description 3
- 238000003786 synthesis reaction Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000005538 encapsulation Methods 0.000 claims 1
- 210000005003 heart tissue Anatomy 0.000 claims 1
- 230000011164 ossification Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 abstract description 6
- 238000012549 training Methods 0.000 abstract description 5
- 238000011160 research Methods 0.000 abstract description 4
- 239000012858 resilient material Substances 0.000 abstract description 4
- 238000001514 detection method Methods 0.000 abstract description 3
- 238000012545 processing Methods 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 19
- 239000000243 solution Substances 0.000 description 17
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 10
- 239000000203 mixture Substances 0.000 description 8
- 238000003384 imaging method Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 4
- 238000002059 diagnostic imaging Methods 0.000 description 4
- 238000007711 solidification Methods 0.000 description 4
- 230000008023 solidification Effects 0.000 description 4
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 210000000689 upper leg Anatomy 0.000 description 3
- 150000003926 acrylamides Chemical class 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000013170 computed tomography imaging Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000013332 literature search Methods 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 125000004437 phosphorous atom Chemical group 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Abstract
A kind of High-precision multi-tissue simulation fetal model, belongs to medical application research field.The imitative Foetal organ that this model mainly comprises imitative fetal bone prepared by calcium hydroxy phosphate, prepared by resilient material and imitative fetus musculature prepared by resilient material, it is characterized in that: according to the computed tomography data of fetus, adopt three-dimensional printing technology to prepare the high precision acrylonitrile-butadiene-styrene (ABS) plastic pattern of fetus, and prepare emulation fetus silica gel mould by this model; And the imitative Foetal organ of preparation, imitative fetal bone are fixed in a mold, and carry out the cast of imitative musculature material, complete the preparation of emulation fetal model.Emulation fetal model prepared by the present invention provides the character such as ultrasonic, X ray detection of outside fetus emulation shape and internal, bone, has a wide range of applications in fields such as medical training teaching, Medical Image Processing, Medical Devices detections.
Description
Technical field
What the present invention relates to is a kind of method of medical application research field, specifically a kind of High-precision multi-tissue simulation fetal model.
Background technology
Along with developing rapidly of computing machine, image technique and signal processing technology, B ultrasonic imaging, doppler ultrasound, ultrasonic CT imaging etc. all obtain applying comparatively widely at medical field.In order to ensure human-body safety, various imitative organization material model is also applied to medical field gradually.Medical emulation fetal model has corresponding research and uses in fields such as medical training teaching, Medical Image Processing, Medical Devices detections.Therefore, the High-precision multi-tissue simulation fetal model of the present invention's research has important using value.
Through finding the literature search of prior art, the simulation that CIRS company of the U.S. (www.cirsinc.com) utilizes special gel to prepare 20 weeks and 36 weeks fetuses are to detect the serviceability of medical imaging device; KyotoKagaku company of Japan (www.kyotokagaku.com) has set forth the performance utilizing simulation 23 weeks fetus die body test medical imaging devices.ATSLaboratories company of the U.S. (www.atslabs.com) is by the performance etc. of simulation 36-40 week fetal monitoring imaging device.
These methods are all detect medical imaging device serviceability by emulation fetal model above, only consider the musculature of fetus and do not consider the organ-tissue, skeletal tissue etc. of fetus when their Problems existing are simulation fetuses.Therefore, be difficult to experience with real medical technology to student in medical training teaching; The image that the image obtained by Medical imaging systems and true fetus are obtained under Medical Ultrasonic Imaging System is had any different, as: under Medical Ultrasonic Imaging System, brightness of image is low, contrast is low for the musculature of true fetus, and the brightness of image that the musculature simulating fetus obtains under Medical Ultrasonic Imaging System is high, contrast is high.
Summary of the invention
The present invention in view of the above problems, its object is to: provide a kind of emulation fetal model comprising imitative musculature, imitative bone and multiple organ.
A kind of High-precision multi-tissue simulation fetal model, this model mainly comprises imitative fetal bone tissue, imitative fetal organic tissue and imitative fetus musculature, it is characterized in that: according to the computed tomography data of fetus, adopt three-dimensional printing technology to prepare the high precision acrylonitrile-butadiene-styrene (ABS) plastic pattern of fetus, and go out to emulate fetus silica gel mould by this model manufacturing; And the imitative Foetal organ of preparation, imitative fetal bone are fixed in a mold, and carry out the cast of imitative musculature material, complete the preparation of emulation fetal model.
Preparation is that fetus musculature imitated by the gel of main material with acrylate copolymer, according to mass percent component be: acrylamide 10%, metagin 0.25%, methylene-bisacrylamide 0.25%, ethylene glycol 8%, tetramethylethylenediamine 0.30%, NaOH 0.10%, ammonium persulfate 0.10%, alumina powder 3%, distilled water 78%.
Preparation take acrylate copolymer as liver, lung, kidney, the heart that fetus imitated by the gel of main material, according to mass percent component be: acrylamide 7% ~ 12%, metagin 0.25%, methylene-bisacrylamide 0.25%, ethylene glycol 6% ~ 8%, tetramethylethylenediamine 0.30%, NaOH 0.10%, ammonium persulfate 0.10%, boron nitride powder 1% ~ 9%, distilled water 70% ~ 85%.
With the analytical reagent of calcic and phosphorus for Material synthesis calcium hydroxy phosphate, and preparation take calcium hydroxy phosphate as imitative fetal skull, vertebra, the femur of principal ingredient; According to mass percent component be: calcium hydroxy phosphate 56%, polyacrylic acid 28%, citric acid 9%, phosphoric acid 7%.
Imitative fetal bone preparation flow is as follows: first CT bone scan data are converted to the data layout printing function read-write, carries out the preparation of ABS (acrylonitrile-butadiene-styrene (ABS) plastics) prototype; Then be configured by ABS bone prototype and pour into a mould silica gel, after silica gel solidification, carrying out parting, taking out the upper and lower mould that ABS prototype obtains silica gel mould; Finally carry out hydroxyapatite slurry cast, imitate after bone solidifies 12 hours until calcium hydroxy phosphate and take out, just obtain the artificial bone prepared.
Further: to adopt three-dimensional printing technology to produce the ABS model (acrylonitrile-butadiene-styrene (ABS) plastic pattern) of fetus according to the computed tomography data of fetus, prepare emulation fetus silica gel mould by ABS model; And imitative Foetal organ, bone are wrapped in silica gel mould, then carry out the cast of imitative musculature material, complete the preparation of emulation fetal model.
High-precision multi-tissue simulation fetal model described in application, is characterized in that, step is as follows:
Step 1): preparing with acrylate copolymer is that fetus musculature imitated by the resilient material of principal ingredient, its primary acoustic parameter is met: the velocity of sound 1540 ± 10% meter per second; Acoustic attenuation coefficient: (0.5 ± 0.05) × 10
-4× f decibel/( meter He Zi); Wherein f represents frequency probe.
Calculate the velocity of sound of imitative musculature sample of material: suppose that the thickness of sample is d, then ultrasonic velocity of sound v in the sample
2for
wherein v
1for the ultrasonic velocity of sound in water, Δ t is that sample inserts the reception ultrasonic pulse time delay caused in water.
Calculate the attenuation coefficient of imitative musculature sample of material: suppose that the thickness of sample is d, then ultrasonic velocity of sound α is in the sample
wherein P
0for sample inserts the peak value of front Received signal strength, P is the peak value of Received signal strength after sample inserts.
Step 2): preparing with acrylate copolymer is the liver, kidney etc. that fetus imitated by the resilient material of principal ingredient.Imitative liver primary acoustic parameter is met: the velocity of sound 1570 ± 10 meter per second; Acoustic attenuation coefficient: (0.7 ± 0.05) × 10
-4× f decibel/( meter He Zi).Imitative kidney primary acoustic parameter is met: the velocity of sound 1560 ± 10 meter per second; Acoustic attenuation coefficient: (1.0 ± 0.05) × 10
-4× f decibel/( meter He Zi); F represents frequency probe.
Step 3): with the analytical reagent of calcic and phosphorus for Material synthesis calcium hydroxy phosphate, and preparation take calcium hydroxy phosphate as the imitative fetal skull, vertebra, femur etc. of principal ingredient.Imitative bone primary acoustic parameter is met: the velocity of sound 3360 ± 10 meter per second; Acoustic attenuation coefficient: (20.0 ± 0.1) × 10
-4× f decibel/( meter He Zi); F represents frequency probe.Imitative fetal bone preparation flow as shown in Figure 1.First CT bone scan data 1 are converted to the data layout printing function read-write, carry out ABS (acrylonitrile-butadiene-styrene (ABS) plastics) prototype 2 and prepare; Then be configured by ABS bone prototype and pour into a mould silica gel 3, after silica gel solidification 4, carrying out parting 5, taking out the upper and lower mould that ABS prototype 6 obtains silica gel mould; Finally carry out hydroxyapatite slurry cast 7, imitate bone solidification until calcium hydroxy phosphate and take out after 80 two hours, just obtain the artificial bone prepared.
Step 4): preparation emulation fetus mould, adopt three-dimensional printing technology to produce the ABS model (acrylonitrile-butadiene-styrene (ABS) plastic pattern) of fetus according to the computed tomography data of fetus, prepare emulation fetus silica gel mould by ABS model.
Step 5): Foetal organ will be imitated, skeletal fixation in emulation fetus mould, and will carry out the cast of imitative musculature material, complete the preparation of emulation fetal model;
The present invention, emulates fetal model to carry out medical teaching training during medical training can be provided to impart knowledge to students; The high emulating image of fetal model under Medical Ultrasonic Imaging System can be obtained, and carry out medical diagnosis simulation etc. according to picture quality.
Accompanying drawing explanation
Fig. 1 is imitative fetal bone preparation flow figure.
Fig. 2 is the ultrasonoscopy of imitative fetal model.
Embodiment
Below embodiments of the invention are elaborated: the present embodiment is implemented under premised on technical solution of the present invention, give detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
Below in conjunction with instantiation, a kind of High-precision multi-tissue simulation fetal model content of the present invention is described in further detail:
Step 1): imitative fetus musculature preparation method: 2.5 grams of metagins and 780 grams of distilled water slowly mix, stirred at ambient temperature about 10 minutes; 100 grams of acrylamides are added in solution, stirred at ambient temperature about 5 minutes, in 2.5 grams of methylene-bisacrylamide gained solution, and stirred at ambient temperature about 10 minutes; 80 grams of ethylene glycol are added in gained solution, stirred at ambient temperature about 1 minute; .30g alumina powder slowly adds in gained solution, stirred at ambient temperature about 8 minutes; 3 grams of tetramethylethylenediamines and 1 gram of NaOH join in gained solution, stirring at room temperature about 1 minute; 1 gram of ammonium persulfate joins in gained solution with very low speed mix and blend; Solution obtained above is poured in mould, is cooled to normal temperature in a mold.The velocity of sound that the imitative musculature sample of material of preparation is measured under frequency is the probe of 1MHz is: 1531.9384 meter per seconds, acoustic attenuation coefficient is 0.5089 × 10
-4decibel/( meter He Zi).
Step 2): imitative human fetal liver tissue preparation method: 2.5 grams of metagins and 800 grams of distilled water slowly mix, stirred at ambient temperature about 10 minutes; 90 grams of acrylamides are added in solution, stirred at ambient temperature about 5 minutes, in 2.5 grams of methylene-bisacrylamide gained solution, and stirred at ambient temperature about 10 minutes; 70 grams of ethylene glycol are added in gained solution, stirred at ambient temperature about 1 minute; 30g boron nitride powder slowly adds in gained solution, stirred at ambient temperature about 8 minutes; 3 grams of tetramethylethylenediamines and 1 gram of NaOH join in gained solution, stirring at room temperature about 1 minute; 1 gram of ammonium persulfate joins in gained solution with very low speed mix and blend; Solution obtained above is poured in mould, is cooled to normal temperature in a mold.The velocity of sound that the imitative liver organization sample of material of preparation is measured under frequency is the probe of 1MHz is: 1564.1208 meter per seconds, acoustic attenuation coefficient is 0.7096 × 10
-4decibel/( meter He Zi).
Step 3): imitative fetal bone tissue preparation method: take calcium nitrate and phosphorus pentoxide than 1.67 by calcium and number of phosphorus atoms, by calcium nitrate aqueous solution and phosphorus pentoxide alcoholic solution mix and blend 4 hours, standing 4 hours, obtains white gels; White di calcium powder within 12 hours, is obtained dry in 120 degree of thermostatic drying chambers for white gels; 9 grams of citric acid solutions are dissolved in 28 grams of polyacrylic acid, add 56 grams of di calcium powders successively and 7 grams of phosphoric acid stir, pour in organic glass mould carry out compacting, solidification, demoulding process can obtain calcium hydroxy phosphate class artificial bone.The velocity of sound that the imitative skeletal tissue sample of material of preparation is measured under frequency is the probe of 1MHz is: 3368.0827 meter per seconds, acoustic attenuation coefficient is 19.5246 × 10
-4decibel/( meter He Zi).
Step 4): the emulation fetus of preparing the long 32cm of body simulates 28 weeks fetuses; The imitative fetus musculature of preparation, liver, lung, kidney, heart and skull, vertebra, femur etc. are carried out combining the emulation fetus obtaining the long 32cm of body and simulates 28 weeks fetuses.As shown in Figure 2, in ultrasonoscopy, imitative musculature 1 presents dark areas to the B ultrasonic image of the imitative fetal model sample prepared, and imitative vertebral bones image 2 is shown as bright areas, and this presents consistent with the muscle of human body and the ultrasonoscopy of bone.
Step 5): the mould of preparation 40 × 25 × 25cm, is placed in emulation fetus in the middle of mould, and fills acrylate copolymer material as a setting, obtains emulating fetal model.
Claims (1)
1. a High-precision multi-tissue simulation fetal model, this model comprises imitative fetal bone tissue, imitative fetal organic tissue and imitative fetus musculature, it is characterized in that: according to the computed tomography data of fetus, adopt three-dimensional printing technology to prepare the high precision acrylonitrile-butadiene-styrene (ABS) plastic pattern of fetus, and go out to emulate fetus silica gel mould by this model manufacturing; And the imitative fetal organic tissue of preparation, imitative fetal bone tissue encapsulation are fixed in emulation fetus silica gel mould, then carry out the cast of imitative musculature material, complete the preparation of emulation fetal model;
Wherein said imitative fetus musculature is that fetus musculature imitated by the gel of main material with acrylate copolymer, its mass percent component is: acrylamide 10%, metagin 0.25%, methylene-bisacrylamide 0.25%, ethylene glycol 8%, tetramethylethylenediamine 0.30%, NaOH 0.10%, ammonium persulfate 0.10%, alumina powder 3%, distilled water 78%;
Wherein said imitative fetal organic tissue take acrylate copolymer as liver, lung, kidney, the heart tissue that fetus imitated by the gel of main material, its mass percent component is: acrylamide 7% ~ 12%, metagin 0.25%, methylene-bisacrylamide 0.25%, ethylene glycol 6% ~ 8%, tetramethylethylenediamine 0.30%, NaOH 0.10%, ammonium persulfate 0.10%, boron nitride powder 1% ~ 9%, distilled water 70% ~ 85%;
Described imitative fetal bone tissue is with the analytical reagent of calcic and phosphorus for Material synthesis calcium hydroxy phosphate, and preparation take calcium hydroxy phosphate as imitative fetal skull, vertebra, the bone formation of principal ingredient; Its mass percent component is: calcium hydroxy phosphate 56%, polyacrylic acid 28%, citric acid 9%, phosphoric acid 7%;
Wherein said imitative fetal bone Tissue preparation protocol is as follows: first CT bone scan data are converted to the data layout printing function read-write, carries out the preparation of acrylonitrile-butadiene-styrene (ABS) plastics bone prototype; Then be configured by acrylonitrile-butadiene-styrene (ABS) plastics bone prototype and poured into a mould silica gel, treating that silica gel solidifies laggard row parting, taking out the upper and lower mould that acrylonitrile-butadiene-styrene (ABS) plastics bone prototype obtains silica gel mould; Finally carry out hydroxyapatite slurry cast, imitate after bone solidifies 12 hours until calcium hydroxy phosphate and take out, just obtain the imitative fetal bone tissue prepared.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4936862A (en) * | 1986-05-30 | 1990-06-26 | Walker Peter S | Method of designing and manufacturing a human joint prosthesis |
| CN1293946A (en) * | 1999-10-25 | 2001-05-09 | 赛伯特株式会社 | Method and appts. for making model of internal target of human body |
| CN101816590A (en) * | 2010-03-10 | 2010-09-01 | 南方医科大学 | Method for manufacturing navigation template of human bone surgery and female die thereof |
| CN101964155A (en) * | 2010-09-16 | 2011-02-02 | 南方医科大学 | Method for manufacturing anthropotomy cast specimen model |
| CN102187379A (en) * | 2008-09-25 | 2011-09-14 | Cae医疗保健有限公司 | Simulation of medical imaging |
-
2013
- 2013-12-09 CN CN201310664607.5A patent/CN103617761B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4936862A (en) * | 1986-05-30 | 1990-06-26 | Walker Peter S | Method of designing and manufacturing a human joint prosthesis |
| CN1293946A (en) * | 1999-10-25 | 2001-05-09 | 赛伯特株式会社 | Method and appts. for making model of internal target of human body |
| CN102187379A (en) * | 2008-09-25 | 2011-09-14 | Cae医疗保健有限公司 | Simulation of medical imaging |
| CN101816590A (en) * | 2010-03-10 | 2010-09-01 | 南方医科大学 | Method for manufacturing navigation template of human bone surgery and female die thereof |
| CN101964155A (en) * | 2010-09-16 | 2011-02-02 | 南方医科大学 | Method for manufacturing anthropotomy cast specimen model |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2675062C1 (en) * | 2017-12-26 | 2018-12-14 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский университет "Московский институт электронной техники" | Artificial muscle for heart tissue |
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