CN103617761A - High-precision multi-tissue simulation fetal model - Google Patents

High-precision multi-tissue simulation fetal model Download PDF

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CN103617761A
CN103617761A CN201310664607.5A CN201310664607A CN103617761A CN 103617761 A CN103617761 A CN 103617761A CN 201310664607 A CN201310664607 A CN 201310664607A CN 103617761 A CN103617761 A CN 103617761A
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fetus
model
fetal
imitative
simulation
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CN103617761B (en
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祝海江
齐海波
宋健
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Beijing University of Chemical Technology
Shijiazhuang Tiedao University
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Beijing University of Chemical Technology
Shijiazhuang Tiedao University
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Abstract

The invention discloses a high-precision multi-tissue simulation fetal model, and belongs to the field of medical applied researches. The model mainly comprises simulation fetal bones, simulation fetal organs and simulation fetal muscular tissues, wherein the simulation fetal bones are made of hydroxyapatite, the simulation fetal organs are made of elastic materials, the simulation fetal muscular tissues are made of elastic materials, and the model is characterized in that according to computed tomography data of a fetus, the three-dimensional printing technology is adopted to make a fetal high-precision acrylonitrile-butadiene-styrene plastic model, and a simulation fetal silicone mold is made through the model. The manufactured simulation fetal organs and the simulation fetal bones are fixed in the mold, simulation muscular tissue material pouring is carried out, and the manufacturing of the simulation fetal model is completed. The manufactured simulation fetal model provides the characteristics such as ultrasound and X-ray detection of the external fetal simulation shape, the internal organs and the bones, and is widely applied to the fields, such as medical training and teaching, medical image processing and medical equipment detection.

Description

A kind of high precision is organized emulation fetus model more
Technical field
What the present invention relates to is a kind of method of medical application research field, and specifically a kind of high precision is organized emulation fetus model more.
Background technology
Along with developing rapidly of computing machine, image technique and signal processing technology, B ultrasonic imaging, doppler ultrasound, ultrasonic CT imaging etc. all obtain applying comparatively widely at medical field.In order to guarantee human-body safety, various imitative organization material models are also applied to medical field gradually.Medical emulation fetus model has corresponding research and use in fields such as medical training teaching, Medical Image Processing, Medical Devices detections.Therefore, the high precision of the present invention's research organizes emulation fetus model to have important using value more.
Through the literature search of prior art is found, U.S. CIRS company (www.cirsinc.com) utilizes simulation prepared by special gel 20 weeks and 36 weeks fetuses to detect the serviceability of medical imaging device; Japan Kyoto Kagaku company (www.kyotokagaku.com) has set forth the performance of utilizing 23 weeks fetus die body test medical imaging devices of simulation.U.S. ATS Laboratories company (www.atslabs.com) passes through the performance of simulation 36-40 week fetal monitoring imaging device etc.
These methods are all to detect medical imaging device serviceability by emulation fetus model above, only considered the musculature of fetus and do not consider the organ-tissue, skeletal tissue etc. of fetus when the problem that their exist is simulation fetus.Therefore, be difficult to student, with real medical technology, experience in medical training teaching; The image obtaining by Medical imaging systems is had any different with the image that true fetus obtains under Medical Ultrasonic Imaging System, as: under Medical Ultrasonic Imaging System, brightness of image is low, contrast is low for the musculature of true fetus, and the brightness of image that the musculature of simulation fetus obtains under Medical Ultrasonic Imaging System is high, contrast is high.
Summary of the invention
In view of the above problems, its object is in the present invention: a kind of emulation fetus model that comprises imitative musculature, imitative bone and multiple organ is provided.
A kind of high precision is organized emulation fetus model more, this model mainly comprises imitative fetal bone tissue, imitative fetal organic tissue and imitative fetus musculature, it is characterized in that: according to the computed tomography data of fetus, adopt three-dimensional printing technology to prepare the high precision acrylonitrile-butadiene-styrene (ABS) plastic pattern of fetus, and go out emulation fetus silica gel mould by this model manufacturing; And the imitative fetus organ of preparation, imitative fetal bone are fixed in mould, and imitate the cast of musculature material, complete the preparation of emulation fetus model.
The imitative fetus musculature of gel that acrylate copolymer is main material is take in preparation, according to mass percent component, be: acrylamide 10%, metagin 0.25%, methylene-bisacrylamide 0.25%, ethylene glycol 8%, tetramethylethylenediamine 0.30%, NaOH 0.10%, ammonium persulfate 0.10%, alumina powder 3%, distilled water 78%.
Liver, lung, kidney, the heart of the imitative fetus of gel that acrylate copolymer is main material are take in preparation, according to mass percent component, be: acrylamide 7%~12%, metagin 0.25%, methylene-bisacrylamide 0.25%, ethylene glycol 6%~8%, tetramethylethylenediamine 0.30%, NaOH 0.10%, ammonium persulfate 0.10%, boron nitride powder 1%~9%, distilled water 70%~85%.
The analytical reagent of calcic and phosphorus of take is raw material synthesis of hydroxy calcium phosphate, and imitative fetal skull, vertebra, the femur that calcium hydroxy phosphate is principal ingredient take in preparation; According to mass percent component, be: calcium hydroxy phosphate 56%, polyacrylic acid 28%, citric acid 9%, phosphoric acid 7%.
Imitative fetal bone preparation flow is as follows: first CT bone scan data-switching is become to print the data layout of function read-write, carry out the preparation of ABS (acrylonitrile-butadiene-styrene (ABS) plastics) prototype; Then by ABS bone prototype, be configured and pour into a mould silica gel, after silica gel solidifies, carrying out parting, taking out the upper and lower mould that ABS prototype obtains silica gel mould; Finally carry out the cast of hydroxyapatite slurry, after the imitative bone of calcium hydroxy phosphate solidifies 12 hours, take out, just obtain the artificial bone preparing.
Further: according to the computed tomography data of fetus, to adopt three-dimensional printing technology to produce the ABS model (acrylonitrile-butadiene-styrene (ABS) plastic pattern) of fetus, by ABS model, prepare emulation fetus silica gel mould; And will imitate fetus organ, bone is wrapped in silica gel mould, then imitates musculature material cast, completes the preparation of emulation fetus model.
The described high precision of application is organized emulation fetus model more, it is characterized in that, step is as follows:
Step 1): the imitative fetus musculature of resilient material that acrylate copolymer is principal ingredient is take in preparation, its main parameters,acoustic is met: the velocity of sound 1540 ± 10% meter per seconds; Acoustic attenuation coefficient: (0.5 ± 0.05) * 10 -4* f decibel/( meter He Zi); Wherein f represents frequency probe.
Calculate the velocity of sound of imitative musculature sample of material: the thickness of supposing sample is d, ultrasonic velocity of sound v in sample 2for
Figure BDA0000433518350000031
v wherein 1for the ultrasonic velocity of sound in water, Δ t is that sample inserts the reception ultrasonic pulse time delay causing in water.
Calculate the attenuation coefficient of imitative musculature sample of material: the thickness of supposing sample is d, and ultrasonic velocity of sound α in sample is p wherein 0for sample inserts the front peak value that receives signal, P receives the peak value of signal after sample inserts.
Step 2): the liver, kidney etc. of the imitative fetus of resilient material that acrylate copolymer is principal ingredient are take in preparation.The imitative main parameters,acoustic of liver is met: the velocity of sound 1570 ± 10 meter per seconds; Acoustic attenuation coefficient: (0.7 ± 0.05) * 10 -4* f decibel/( meter He Zi).The imitative main parameters,acoustic of kidney is met: the velocity of sound 1560 ± 10 meter per seconds; Acoustic attenuation coefficient: (1.0 ± 0.05) * 10 -4* f decibel/( meter He Zi); F represents frequency probe.
Step 3): the analytical reagent of calcic and phosphorus of take is raw material synthesis of hydroxy calcium phosphate, and preparation take imitative fetal skull that calcium hydroxy phosphate is principal ingredient, vertebra, femur etc.The imitative main parameters,acoustic of bone is met: the velocity of sound 3360 ± 10 meter per seconds; Acoustic attenuation coefficient: (20.0 ± 0.1) * 10 -4* f decibel/( meter He Zi); F represents frequency probe.Imitative fetal bone preparation flow as shown in Figure 1.First CT bone scan data 1 are converted to the data layout of printing function read-write, carry out 2 preparations of ABS (acrylonitrile-butadiene-styrene (ABS) plastics) prototype; Then by ABS bone prototype, be configured and pour into a mould silica gel 3, after silica gel solidifies 4, carrying out parting 5, taking out the upper and lower mould that ABS prototype 6 obtains silica gel mould; Finally carry out hydroxyapatite slurry cast 7, after the imitative bone of calcium hydroxy phosphate solidifies 80 two hours, take out, just obtain the artificial bone preparing.
Step 4): preparation emulation fetus mould, according to the computed tomography data of fetus, adopt three-dimensional printing technology to produce the ABS model (acrylonitrile-butadiene-styrene (ABS) plastic pattern) of fetus, by ABS model, prepare emulation fetus silica gel mould.
Step 5): will imitate fetus organ, skeletal fixation in emulation fetus mould, and imitate the cast of musculature material, and complete the preparation of emulation fetus model;
The present invention, can provide in medical training teaching emulation fetus model to carry out medical teaching training; Can obtain the high emulating image of fetus model under Medical Ultrasonic Imaging System, and carry out medical diagnosis simulation etc. according to picture quality.
Accompanying drawing explanation
Fig. 1 is imitative fetal bone preparation flow figure.
Fig. 2 is the ultrasonoscopy of imitative fetus model.
Embodiment
Below embodiments of the invention are elaborated: the present embodiment is implemented take technical solution of the present invention under prerequisite, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
Below in conjunction with instantiation, to a kind of high precision of the present invention, organize emulation fetus model content to be described in further detail more:
Step 1): imitative fetus musculature preparation method: 2.5 grams of metagins and 780 grams of distilled water slowly mix, and under room temperature, stir about is 10 minutes; 100 grams of acrylamides are added in solution, and under room temperature, stir about is 5 minutes, and in 2.5 grams of methylene-bisacrylamide gained solution, under room temperature, stir about is 10 minutes; 80 grams of ethylene glycol are added in gained solution, and under room temperature, stir about is 1 minute; .30g alumina powder slowly adds in gained solution, and under room temperature, stir about is 8 minutes; 3 grams of tetramethylethylenediamines and 1 gram of NaOH join in gained solution, stirring at room approximately 1 minute; 1 gram of ammonium persulfate joins in gained solution with very low speed mix and blend; Solution obtained above is poured in mould, in mould, be cooled to normal temperature.The velocity of sound of measuring under the probe that the imitative musculature sample of material of preparation is 1MHz in frequency is: 1531.9384 meter per seconds, acoustic attenuation coefficient is 0.5089 * 10 -4decibel/( meter He Zi).
Step 2): imitative human fetal liver tissue preparation method: 2.5 grams of metagins and 800 grams of distilled water slowly mix, and under room temperature, stir about is 10 minutes; 90 grams of acrylamides are added in solution, and under room temperature, stir about is 5 minutes, and in 2.5 grams of methylene-bisacrylamide gained solution, under room temperature, stir about is 10 minutes; 70 grams of ethylene glycol are added in gained solution, and under room temperature, stir about is 1 minute; 30g boron nitride powder slowly adds in gained solution, and under room temperature, stir about is 8 minutes; 3 grams of tetramethylethylenediamines and 1 gram of NaOH join in gained solution, stirring at room approximately 1 minute; 1 gram of ammonium persulfate joins in gained solution with very low speed mix and blend; Solution obtained above is poured in mould, in mould, be cooled to normal temperature.The velocity of sound of measuring under the probe that the imitative liver organization sample of material of preparation is 1MHz in frequency is: 1564.1208 meter per seconds, acoustic attenuation coefficient is 0.7096 * 10 -4decibel/( meter He Zi).
Step 3): imitative fetal bone tissue preparation method: by calcium and number of phosphorus atoms, than 1.67, take calcium nitrate and phosphorus pentoxide, by calcium nitrate aqueous solution and phosphorus pentoxide alcoholic solution mix and blend 4 hours, standing 4 hours, obtain white gels; White gels is dried and within 12 hours, obtains white calcium hydroxy phosphate powder in 120 degree thermostatic drying chambers; 9 grams of citric acid solutions are dissolved in 28 grams of polyacrylic acid, add successively 56 grams of calcium hydroxy phosphate powder and 7 grams of phosphoric acid to stir, pour in organic glass mould, carry out compacting, solidify, the demoulding processes and can obtain calcium hydroxy phosphate class artificial bone.The velocity of sound of measuring under the probe that the imitative skeletal tissue sample of material of preparation is 1MHz in frequency is: 3368.0827 meter per seconds, acoustic attenuation coefficient is 19.5246 * 10 -4decibel/( meter He Zi).
Step 4): the emulation fetus of preparing the long 32cm of body is simulated 28 weeks fetuses; Imitative fetus musculature, liver, lung, kidney, heart and skull, the vertebra of preparation, femur etc. are combined to the emulation fetus that obtains the long 32cm of body and simulate 28 weeks fetuses.As shown in Figure 2, in ultrasonoscopy, imitative musculature 1 presents dark areas to the B ultrasonic image of the imitative fetus model sample preparing, and imitative vertebral bones image 2 is shown as bright areas, and this presents consistent with the muscle of human body and the ultrasonoscopy of bone.
Step 5): prepare the mould of 40 * 25 * 25cm, emulation fetus is placed in the middle of mould, and fills acrylate copolymer material as a setting, obtain emulation fetus model.

Claims (5)

1. a high precision is organized emulation fetus model more, this model mainly comprises imitative fetal bone tissue, imitative fetal organic tissue and imitative fetus musculature, it is characterized in that: according to the computed tomography data of fetus, adopt three-dimensional printing technology to prepare the high precision acrylonitrile-butadiene-styrene (ABS) plastic pattern of fetus, and go out emulation fetus silica gel mould by this model manufacturing; And the imitative fetus organ of preparation, imitative fetal bone are fixed in mould, and imitate the cast of musculature material, complete the preparation of emulation fetus model.
2. be applied to high precision claimed in claim 1 and organize emulation fetus model more, it is characterized in that: the imitative fetus musculature of gel that acrylate copolymer is main material is take in preparation, according to mass percent component, be: acrylamide 10%, metagin 0.25%, methylene-bisacrylamide 0.25%, ethylene glycol 8%, tetramethylethylenediamine 0.30%, NaOH 0.10%, ammonium persulfate 0.10%, alumina powder 3%, distilled water 78%.
3. high precision according to claim 1 is organized emulation fetus model more, it is characterized in that: liver, lung, kidney, the heart of the imitative fetus of gel that acrylate copolymer is main material are take in preparation, according to mass percent component, be: acrylamide 7%~12%, metagin 0.25%, methylene-bisacrylamide 0.25%, ethylene glycol 6%~8%, tetramethylethylenediamine 0.30%, NaOH 0.10%, ammonium persulfate 0.10%, boron nitride powder 1%~9%, distilled water 70%~85%.
4. high precision according to claim 1 is organized emulation fetus model more, it is characterized in that: the analytical reagent of calcic and phosphorus of take is raw material synthesis of hydroxy calcium phosphate, and imitative fetal skull, vertebra, the femur that calcium hydroxy phosphate is principal ingredient take in preparation; According to mass percent component, be: calcium hydroxy phosphate 56%, polyacrylic acid 28%, citric acid 9%, phosphoric acid 7%.
Imitative fetal bone preparation flow is as follows: first CT bone scan data-switching is become to print the data layout of function read-write, carry out the preparation of ABS (acrylonitrile-butadiene-styrene (ABS) plastics) prototype; Then by ABS bone prototype, be configured and pour into a mould silica gel, after silica gel solidifies, carrying out parting, taking out the upper and lower mould that ABS prototype obtains silica gel mould; Finally carry out the cast of hydroxyapatite slurry, after the imitative bone of calcium hydroxy phosphate solidifies 12 hours, take out, just obtain the artificial bone preparing.
5. high precision according to claim 1 is organized emulation fetus model more, it is characterized in that: according to the computed tomography data of fetus, adopt three-dimensional printing technology to produce the ABS model (acrylonitrile-butadiene-styrene (ABS) plastic pattern) of fetus, by ABS model, prepare emulation fetus silica gel mould; And will imitate fetus organ, bone is wrapped in silica gel mould, then imitates musculature material cast, completes the preparation of emulation fetus model.
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CN105348820A (en) * 2015-12-08 2016-02-24 青华科教仪器有限公司 Simulated human skin material for nursing medical education as well as preparation method and application thereof
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CN106738541A (en) * 2017-01-17 2017-05-31 英诺莱比(北京)科技有限公司 A kind of mosaic technology of copper nut and plastic parts
CN106781956A (en) * 2016-12-14 2017-05-31 三的部落(上海)科技股份有限公司 The method that reusable medical operation training pattern is obtained using 3D printing
CN106847040A (en) * 2017-03-03 2017-06-13 宁波维迈医疗科技有限公司 Human body organa parenchymatosum's model preparation method
CN107067924A (en) * 2017-04-17 2017-08-18 营口巨成教学科技开发有限公司 One kind emulation fetus
CN107657880A (en) * 2016-07-26 2018-02-02 上海光韵达数字医疗科技有限公司 A kind of manufacturing process of human organ model
CN108806446A (en) * 2017-11-24 2018-11-13 安徽农业大学 A kind of production method of diagnosis of early gestation teaching mode and application
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105348820A (en) * 2015-12-08 2016-02-24 青华科教仪器有限公司 Simulated human skin material for nursing medical education as well as preparation method and application thereof
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CN107657880A (en) * 2016-07-26 2018-02-02 上海光韵达数字医疗科技有限公司 A kind of manufacturing process of human organ model
CN106128257A (en) * 2016-08-16 2016-11-16 杭州科霖医疗科技有限公司 A kind of method utilizing rapid prototyping technology to make personalization emulation anatomical model
CN106182509A (en) * 2016-08-31 2016-12-07 英诺莱比(北京)科技有限公司 Use the operational approach of silica gel mould post forming
CN106781956A (en) * 2016-12-14 2017-05-31 三的部落(上海)科技股份有限公司 The method that reusable medical operation training pattern is obtained using 3D printing
CN106738541A (en) * 2017-01-17 2017-05-31 英诺莱比(北京)科技有限公司 A kind of mosaic technology of copper nut and plastic parts
CN106847040A (en) * 2017-03-03 2017-06-13 宁波维迈医疗科技有限公司 Human body organa parenchymatosum's model preparation method
CN107067924A (en) * 2017-04-17 2017-08-18 营口巨成教学科技开发有限公司 One kind emulation fetus
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CN108806446A (en) * 2017-11-24 2018-11-13 安徽农业大学 A kind of production method of diagnosis of early gestation teaching mode and application
CN115122814A (en) * 2022-07-21 2022-09-30 北京共赏文化传媒有限公司 Art sculpture method

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