CA2523262A1 - Artificial valve prosthesis with improved flow dynamics - Google Patents

Artificial valve prosthesis with improved flow dynamics Download PDF

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Publication number
CA2523262A1
CA2523262A1 CA002523262A CA2523262A CA2523262A1 CA 2523262 A1 CA2523262 A1 CA 2523262A1 CA 002523262 A CA002523262 A CA 002523262A CA 2523262 A CA2523262 A CA 2523262A CA 2523262 A1 CA2523262 A1 CA 2523262A1
Authority
CA
Canada
Prior art keywords
leaflets
radially expandable
support structure
valve prosthesis
prosthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002523262A
Other languages
French (fr)
Other versions
CA2523262C (en
Inventor
Brian C. Case
Jacob A. Flagle
Michael L. Garrison
Andrew K. Hoffa
Darin G. Schaeffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cook Medical Technologies LLC
Original Assignee
Cook Incorporated
Brian C. Case
Jacob A. Flagle
Michael L. Garrison
Andrew K. Hoffa
Darin G. Schaeffer
Cook Medical Technologies Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cook Incorporated, Brian C. Case, Jacob A. Flagle, Michael L. Garrison, Andrew K. Hoffa, Darin G. Schaeffer, Cook Medical Technologies Llc filed Critical Cook Incorporated
Publication of CA2523262A1 publication Critical patent/CA2523262A1/en
Application granted granted Critical
Publication of CA2523262C publication Critical patent/CA2523262C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2475—Venous valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2002/068—Modifying the blood flow model, e.g. by diffuser or deflector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0054—V-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0073—Quadric-shaped
    • A61F2230/0076—Quadric-shaped ellipsoidal or ovoid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0073—Quadric-shaped
    • A61F2230/0078—Quadric-shaped hyperboloidal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0073—Quadric-shaped
    • A61F2230/008—Quadric-shaped paraboloidal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0037—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in height or in length
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter

Abstract

An expandable venous valve having a support structure (11) that configured to enlarge the area adjacent to the valve structure (12) such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus (34) adjacent the valve structure in an unsupported section of vessel wall between two support frame section or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure. In another group of embodiments, the attachment pathway between opposing leaflets and the support frame and/or vessel wall comprises a proximal portion that places the leaflets in extended contact with one another and a distal portion forms a large angle with respect to the adjacent walls such that a large pocket is created at the base of the leaflets. In one embodiment, the attachment pathway extends distally along a pair of substantially parallel longitudinal attachment struts to create an extended leaflet contact area, then angles circumferentially and distally from the former along distal attachment struts to define the bottom edge of the leaflets.

Claims (29)

1. A radially expandable artificial valve prosthesis for deployment in a bodily passage, comprising:

a valve structure adapted for restricting fluid flow therethrough;
a support structure attached to the valve structure, wherein at least a portion of the the support structure is adapted to expand upon deployment to create an artificial sinus in the bodily passage adjacent to the valve structure; and wherein the artificial sinus is configured to create retrograde flow vortices sufficient to substantially prevent stagnation of fluid therein.
2. The radially expandable artificial valve prosthesis of claim 1, wherein the support structure is expandable to a particular diameter upon deployment, and wherein the valve prosthesis is configured such that the artificial sinus comprises a portion of the bodily passage that is substantially unsupported by the support structure such that the artificial sinus is adapted to assume a diameter that is larger than the deployment diameter of the adjacent support structure.
3. The radially expandable artificial valve prosthesis of claim 2, wherein the sinus has a proximal and distal end such that support structure include a first portion disposed adjacent to the proximal end of the sinus and an interconnecting second portion adjacent to the distal end of the sinus.
4. The radially expandable artificial valve prosthesis of claim 3, wherein the first and second portions of the support structure are interconnected by a pair of oppositely placed struts.
5. The radially expandable artificial valve prosthesis of claim 4, wherein in the valve structure is connected at least in part to the oppositely placed struts.
6. The radially expandable artificial valve prosthesis of claim 1, wherein the support structure comprises a first end and a second end, wherein the valve structure is located about the first end and the first end of support structure has an enlarged diameter that is configured to create the artificial sinus about the valve structure.
7. The radially expandable artificial valve prosthesis of claim 1, wherein the expandable support structure includes an intermediate portion, a proximal portion, and a distal portion; wherein the intermediate portion has a diameter that is larger than the diameter of the distal and proximal portions such that an artificial sinus is created thereabout.
8. The radially expandable artificial valve prosthesis of claim 7, wherein the intermediate, proximal, and distal portion comprise interconnected segments.
9. The radially expandable artificial valve prosthesis of claim 8, wherein the intermediate portion comprises a first and a second radially expandable anchoring portion that each include a first end, a second end and at least one constraining mechanism configured with the first end and the second end of the first and second radially expandable anchoring portion being of different diameters such that the first and second radially expandable anchoring portions collectively form the artificial sinus.
10. The radially expandable artificial valve prosthesis of claim 7, wherein the intermediate portion comprises the artificial sinus that forms a expanded portion extending outward from adjacent portions of the collapsible support structure.
11. The radially expandable artificial valve prosthesis of claim 10, wherein the support structure comprises a superelastic material.
12. The radially expandable artificial valve prosthesis of claim 11, wherein the superelastic material comprises nitinol.
13. A radially expandable artificial valve prosthesis for deployment in a bodily passage, comprising:

a valve structure, including a plurality of leaflets adapted to restrict fluid flow therethrough;
a support structure attached to the valve structure;
wherein each of the plurality of leaflets is oriented closely with the longitudinal axis of the bodily passage throughout the majority of the lengths thereof with the distal portions thereof extending circumferentially and distally to form a seal with at least one of the walls of the bodily passage and the support structure; and wherein the configuration of the leaflets creates pockets between the leaflets and the walls of the bodily passage of sufficient size and shape to facilitate the creation of retrograde flow patterns capable of reducing stagnation of fluid therein.
14. A radially expandable artificial valve prosthesis for deployment in a bodily passage, comprising:
a valve structure comprising leaflets adapted to restrict fluid flow therethrough;
a support structure attached to the valve structure;
a covering of material extending over the support structure;
wherein the support structure includes a first section having a first diameter and a second section attached below the first section having a second diameter substantially smaller than the first diameter such that retrograde flow increases in velocity as it passes through the second section; and wherein the valve structure is located within the second section such that pockets are formed between the valves structure and walls of the bodily passage, the pockets configured to be continually flushed by retrograde flow from above.
15. A radially expandable artificial valve prosthesis for deployment in a bodily passage, comprising:
a valve structure, including a plurality of leaflets adapted to restrict fluid flow therethrough;
a support structure comprising a series of proximal bends comprising commissural points for the attachment of the plurality of leaflets and adjacent distal bends located therebetween, wherein the proximal bends generally define a first angle and the distal bends generally define a second, larger angle such that the leaflets maintain an orientation that is substantially parallel with the bodily passage as they extend proximally from the proximal bends before curving outward to engage at least one of the support structure and the vessel wall; and wherein the orientation of the leaflets is configured such that a pocket is created adjacent the proximal surfaces thereof which is of sufficient size and shape such that fluid flowing in the retrograde direction is capable of achieving flow patterns that reduce stagnation of fluid therein.
16. A radially expandable artificial valve prosthesis for deployment in a bodily passage, comprising:
a valve structure comprising one or more leaflets adapted to restrict fluid flow therethrough, the leaflets includes an inner edge;
a support structure configured to carry the valve structure;
wherein the support structure includes one or more longitudinal attachment struts along which the at least a portion leaflets are attached, the longitudinal attachment struts oriented substantially longitudinally with respect to the device such that the leaflet are coaptable with one another over a substantial portion of their length when the device is implanted within the body passage.
17. The radially expandable artificial valve prosthesis of claims 16, wherein the support structure comprises a first and a second substantially parallel longitudinal attachment struts and a pair of opposing leaflets attached therealong.
18. The radially expandable artificial valve prosthesis of claim 16, wherein the valve includes a pair of commissural points spanning an orifice created between the leaflets, and wherein the support structure includes a first and a second longitudinal attachment strut extending distally from each commissural point, the first and second longitudinal attachment struts defining a first angle therebetween that is less than 30°.
19. The radially expandable artificial valve prosthesis of claim 16, wherein the first angle is less than 20°.
20. The radially expandable artificial valve prosthesis of claim 16, wherein the first angle is less than 10°.
21. The radially expandable artificial valve prosthesis of claim 16, wherein the two longitudinal attachment struts extend generally parallel to one another from each of the commissural points.
22. A radially expandable artificial valve prosthesis for implantation in a vessel comprising:
a support structure having a first end that includes at least a first and a second commissure, and second end located distal thereto;

a plurality of leaflets, each having an outer edge that includes a first lateral edge extending distally from the first commissure and a second edge portion extending distally from the second commissure, the first and second lateral edges generally converging about the second end such that the plurality of leaflets collectively form a seal with the walls of the vessel and cooperate with one another to restrict fluid flow therethrough; and wherein the first and second lateral edges are each attached to the support structure along an attachment pathway that includes a first, proximal portion comprising a substantial portion of the length of the prosthesis having primarily a longitudinal orientation with respect to the longitudinal axis of the prosthesis, and a second, distal portion angling obliquely from the first portion such that plurality of leaflets each comprise an extensive coaptable portion that defines the side of a large pocket located adjacent to each leaflet, and a basal portion that defines the bottom of the pocket when the prosthesis is implanted within the vessel.
23. A radially expandable artificial valve prosthesis for implantation in a vessel comprising:
a support structure having a first end that includes a first and a second commissure, and second end located distal thereto;
a pair of leaflets, each having an outer edge that includes a first lateral edge extending distally from the first commissure and a second edge portion extending distally from the second commissure, the first and second lateral edges generally converging about the second end such that the plurality of leaflets collectively form a seal with the walls of the vessel and cooperate with one another to restrict fluid flow therethrough; and wherein the first and second lateral edges are each attached about a first strut that extends from the first and second commissure structure along an attachment pathway that includes a first, proximal portion comprising a substantial portion of the length of the prosthesis having primarily a longitudinal orientation with respect to the longitudinal axis of the prosthesis, and a second, distal portion angling obliquely from the first portion such that plurality of leaflets each comprise an extensive coaptable portion that defines the side of a large pocket located adjacent to each leaflet, and a basal portion that defines the bottom of the pocket when the prosthesis is implanted within the vessel.
24. A radially expandable artificial valve prosthesis for deployment in a bodily passage, comprising:
a valve structure, including a plurality of leaflets adapted to restrict fluid flow therethrough, each of the plurality of leaflets comprising a free inner edge and an outer edge that includes a first and second lateral outer edge which interconnect distally to form a bottom edge;
a support structure comprising a series of proximal bends comprising commissural points for the attachment of the plurality of leaflets; and longitudinal attachment struts extending distally therefrom, the support structure further comprising a pair of distal attachment struts extending distally and circumferentially from the longitudinal attachment struts; and wherein the lateral outer edges are attached proximally along the longitudinal attachment struts to form a extensive leaflet contact area, and distally long the distal attachment struts which converge laterally and carry the bottom edge of each of the plurality of leaflets such that the prosthesis is adapted for forming a seal between the plurality of leaflets and the walls of the bodily passage and creating a large pocket at the base of each of the plurality of leaflets that is of sufficient size and shape such that fluid flowing in the retrograde direction is capable of achieving flow patterns that reduce stagnation of fluid therein.
25. The radially expandable artificial valve prosthesis of claim 24, wherein the longitudinal attachment struts are sized to create a leaflet contact area that comprises 10-80% of the length of the valve structure.
26. The radially expandable artificial valve prosthesis of claim 24, wherein the longitudinal attachment struts are sized to create a leaflet contact area that comprises 30-60% of the length of the valve structure.
27. The radially expandable artificial valve prosthesis of claim 24, wherein the longitudinal attachment struts are sized to create a leaflet contact area that comprises 35-55% of the length of the valve structure.
28. A radially expandable artificial valve prosthesis for deployment in a bodily passage, comprising:
a pair of opposing leaflets configured to cooperate with one another to restrict fluid flowing therethrough, each of the opposing leaflets having proximal portion a distal portion, an inner edge traversing the lumen of the bodily passage and an outer edge comprising a first and second lateral outer edge;
wherein the outer edges of the opposing leaflets include an attachment pathway coextending therealong, wherein the attachment pathway comprises an attachment with at least one of a support frame and the inner walls of the bodily passage such that the attachment pathway defines the shape and configuration of the plurality of leaflets when the prosthesis is implanted in the bodily passage, and wherein attachment pathway comprises extends along the first and the second lateral outer edge of each leaflet, each of the first a second lateral outer edges including a proximal attachment pathway portion having a substantially longitudinal orientation with respect to the prosthesis such that a large leaflet contact area is established between the opposing leaflets, and distal attachment pathway portion which converges with that of the other of the first and second lateral outer edge to define a bottom edge of the leaflet such that the bottom portion of the leaflet angles extend laterally from the substantially longitudinally aligned proximal portion in a manner that forms a seal and creates a wide pocket about the junction of the proximal and distal portions that is adapted for creating retrograde flow patterns sufficient to reduce stagnation of fluids therein.
29. A radially expandable artificial valve prosthesis for deployment in a bodily passage, comprising:
a first leaflet having a first and second lateral outer edges and a first leaflet surface;
a second leaflet having a first and second lateral outer edges and a second leaflet surface;
an expandable support structure defining means for positioning the first and second leaflet surfaces substantially opposite one another and substantially along a longitudinal axis of the support structure for a majority of the lengths thereof; and wherein the first and second lateral outer edges of each of the first and second leaflets are attached along the support frame.
CA2523262A 2003-04-24 2004-04-21 Artificial valve prosthesis with improved flow dynamics Expired - Lifetime CA2523262C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US46514103P 2003-04-24 2003-04-24
US60/465,141 2003-04-24
US53078103P 2003-12-18 2003-12-18
US60/530,781 2003-12-18
PCT/US2004/012430 WO2004096100A1 (en) 2003-04-24 2004-04-21 Artificial valve prosthesis with improved flow dynamics

Publications (2)

Publication Number Publication Date
CA2523262A1 true CA2523262A1 (en) 2004-11-11
CA2523262C CA2523262C (en) 2012-01-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2523262A Expired - Lifetime CA2523262C (en) 2003-04-24 2004-04-21 Artificial valve prosthesis with improved flow dynamics

Country Status (8)

Country Link
US (4) US8221492B2 (en)
EP (3) EP2926772A1 (en)
JP (1) JP4940388B2 (en)
AT (1) ATE446061T1 (en)
AU (1) AU2004233848B2 (en)
CA (1) CA2523262C (en)
DE (1) DE602004023708D1 (en)
WO (1) WO2004096100A1 (en)

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US10940167B2 (en) 2012-02-10 2021-03-09 Cvdevices, Llc Methods and uses of biological tissues for various stent and other medical applications
US11406495B2 (en) 2013-02-11 2022-08-09 Cook Medical Technologies Llc Expandable support frame and medical device

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