CA2447354A1 - Method of forming an aerosol for inhalation delivery - Google Patents

Method of forming an aerosol for inhalation delivery Download PDF

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Publication number
CA2447354A1
CA2447354A1 CA002447354A CA2447354A CA2447354A1 CA 2447354 A1 CA2447354 A1 CA 2447354A1 CA 002447354 A CA002447354 A CA 002447354A CA 2447354 A CA2447354 A CA 2447354A CA 2447354 A1 CA2447354 A1 CA 2447354A1
Authority
CA
Canada
Prior art keywords
forming
aerosol
vapor
inhalation therapy
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002447354A
Other languages
French (fr)
Other versions
CA2447354C (en
Inventor
Ron L. Hale
Craig C. Hodges
Peter M. Lloyd
Daniel Mufson
Daniel D. Rogers
Soonho Song
Martin J. Wensley
Daniel J. Myers
Jeffrey A. Mckinney
Reynaldo J. Quintana
Joshua D. Rabinowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alexza Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA2646756A priority Critical patent/CA2646756C/en
Publication of CA2447354A1 publication Critical patent/CA2447354A1/en
Application granted granted Critical
Publication of CA2447354C publication Critical patent/CA2447354C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A61M11/044—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical with electrodes immersed in the liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1075—Preparation of respiratory gases or vapours by influencing the temperature
    • A61M16/109—Preparation of respiratory gases or vapours by influencing the temperature the humidifying liquid or the beneficial agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/16—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas incorporating means for heating or cooling the material to be sprayed
    • B05B7/1686—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas incorporating means for heating or cooling the material to be sprayed involving vaporisation of the material to be sprayed or of an atomising-fluid-generating product
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/368—General characteristics of the apparatus related to heating or cooling by electromagnetic radiation, e.g. IR waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers

Abstract

The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000 ~C/s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 .theta. thick;
and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.
CA002447354A 2001-06-05 2002-05-13 Method of forming an aerosol for inhalation delivery Expired - Lifetime CA2447354C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2646756A CA2646756C (en) 2001-06-05 2002-05-13 Method of forming an aerosol for inhalation delivery

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US29622501P 2001-06-05 2001-06-05
US60/296,225 2001-06-05
US10/057,197 2001-10-26
US10/057,198 2001-10-26
US10/057,198 US20030051728A1 (en) 2001-06-05 2001-10-26 Method and device for delivering a physiologically active compound
US10/057,197 US7766013B2 (en) 2001-06-05 2001-10-26 Aerosol generating method and device
PCT/US2002/015425 WO2002098389A1 (en) 2001-06-05 2002-05-13 Method of forming an aerosol for inhalation delivery

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2646756A Division CA2646756C (en) 2001-06-05 2002-05-13 Method of forming an aerosol for inhalation delivery

Publications (2)

Publication Number Publication Date
CA2447354A1 true CA2447354A1 (en) 2002-12-12
CA2447354C CA2447354C (en) 2008-12-02

Family

ID=27369190

Family Applications (4)

Application Number Title Priority Date Filing Date
CA002447210A Expired - Fee Related CA2447210C (en) 2001-06-05 2002-05-13 Delivery of aerosols containing small particles through an inhalation route
CA002447354A Expired - Lifetime CA2447354C (en) 2001-06-05 2002-05-13 Method of forming an aerosol for inhalation delivery
CA2447081A Expired - Lifetime CA2447081C (en) 2001-06-05 2002-05-13 An aerosol forming device for use in inhalation therapy
CA2646756A Expired - Lifetime CA2646756C (en) 2001-06-05 2002-05-13 Method of forming an aerosol for inhalation delivery

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002447210A Expired - Fee Related CA2447210C (en) 2001-06-05 2002-05-13 Delivery of aerosols containing small particles through an inhalation route

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2447081A Expired - Lifetime CA2447081C (en) 2001-06-05 2002-05-13 An aerosol forming device for use in inhalation therapy
CA2646756A Expired - Lifetime CA2646756C (en) 2001-06-05 2002-05-13 Method of forming an aerosol for inhalation delivery

Country Status (17)

Country Link
US (15) US20030051728A1 (en)
EP (3) EP1392381B9 (en)
JP (4) JP2004532881A (en)
CN (2) CN1304067C (en)
AT (2) ATE503516T1 (en)
AU (4) AU2002311926B2 (en)
CA (4) CA2447210C (en)
CZ (2) CZ20033223A3 (en)
DE (2) DE60239604D1 (en)
ES (1) ES2343678T3 (en)
HK (2) HK1068293A1 (en)
HU (2) HUP0401008A2 (en)
IL (2) IL158955A0 (en)
MX (2) MXPA03011268A (en)
NZ (2) NZ529298A (en)
PL (2) PL373836A1 (en)
WO (3) WO2002098389A1 (en)

Families Citing this family (229)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6962904B1 (en) * 1998-03-13 2005-11-08 Connective Tissue Imagineering Elastin peptide analogs and uses thereof
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
EP1392262A1 (en) * 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US6759029B2 (en) 2001-05-24 2004-07-06 Alexza Molecular Delivery Corporation Delivery of rizatriptan and zolmitriptan through an inhalation route
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US6805853B2 (en) 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
CA2447519C (en) * 2001-05-24 2008-09-16 Alexza Molecular Delivery Corporation Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
GB2381450B (en) * 2001-10-31 2006-05-31 Gw Pharma Ltd Compositions for administration of natural or synthetic cannabinoids by vaporisation
KR20040073438A (en) * 2001-11-19 2004-08-19 벡톤 디킨슨 앤드 컴퍼니 Pharmaceutical compositions in particulate form
EP1446102A1 (en) * 2001-11-21 2004-08-18 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
GB2384184B (en) * 2002-01-10 2005-01-12 Aea Technology Plc Cannabis aerosol
WO2003094900A1 (en) * 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Delivery of drug amines through an inhalation route
US20060193788A1 (en) * 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
JP2006514934A (en) * 2002-11-26 2006-05-18 アレックザ ファーマシューティカルズ， インコーポレイテッド Use of loxapine or amoxapine for the manufacture of drugs for the treatment of pain
AU2003295823B2 (en) * 2002-11-26 2009-11-05 Alexza Pharmaceuticals, Inc. Treatment of headache with antipsychotics delivered by inhalation
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1596824A4 (en) * 2003-02-04 2011-11-23 Chrysalis Tech Inc Aerosol formulations and aerosol delivery of buspirone, buprenorphine, triazolam, cyclobenzaprine and zolpidem
AU2004216550B2 (en) * 2003-02-28 2010-06-03 Ym Biosciences Inc. Opioid delivery system
US7648982B2 (en) * 2003-02-28 2010-01-19 Ym Biosciences Inc. Opioid delivery system
CN1938027A (en) * 2003-02-28 2007-03-28 德莱克斯疗法公司 Opioid delivery system
US7648981B2 (en) * 2003-02-28 2010-01-19 Ym Biosciences Inc. Opioid delivery system
CN100381083C (en) 2003-04-29 2008-04-16 韩力 Electronic nonflammable spraying cigarette
US9119846B2 (en) 2003-04-29 2015-09-01 Neurim Pharmaceuticals (1991) Ltd. Method and composition for enhancing cognition in alzheimer's patients
IL155666A (en) 2003-04-29 2013-12-31 Neurim Pharma 1991 Composition for treating insomnia
JP2007516404A (en) * 2003-05-21 2007-06-21 アレックザ ファーマシューティカルズ， インコーポレイテッド Optically or electrically ignited built-in heating unit and drug supply unit using the same
US20050042177A1 (en) * 2003-07-23 2005-02-24 Elan Pharma International Ltd. Novel compositions of sildenafil free base
CA2534566A1 (en) * 2003-08-04 2005-02-24 Alexza Pharmaceuticals, Inc. Substrates for drug delivery device and methods of preparing and use
US20050037506A1 (en) * 2003-08-04 2005-02-17 Alexza Molecular Delivery Corporation Methods of determining film thicknesses for an aerosol delivery article
US7252050B2 (en) * 2003-09-04 2007-08-07 Maury Dean Cole Substance inhalation system
WO2005037949A2 (en) * 2003-10-07 2005-04-28 Chrysalis Technologies Incorporated Aerosol formulations of butalbital, lorazepam, ipratropium, baclofen, morphine and scopolamine
DE10356925B4 (en) * 2003-12-05 2006-05-11 Lts Lohmann Therapie-Systeme Ag Inhaler for basic active pharmaceutical ingredients and process for its preparation
CN2719043Y (en) 2004-04-14 2005-08-24 韩力 Atomized electronic cigarette
US7402777B2 (en) * 2004-05-20 2008-07-22 Alexza Pharmaceuticals, Inc. Stable initiator compositions and igniters
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
MXPA06014123A (en) 2004-06-03 2007-05-09 Alexza Pharmaceuticals Inc Multiple dose condensation aerosol devices and methods of forming condensation aerosols.
US20100006092A1 (en) * 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
CN101132781A (en) * 2004-12-09 2008-02-27 茵西斯医疗公司 Room-temperature stable dronabinol formulations
FR2880279A1 (en) * 2005-01-05 2006-07-07 Cvb Sarl Sarl MULTI-ODOR DIFFUSION DEVICE
AU2006216696B2 (en) * 2005-02-23 2011-08-18 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations of improved content uniformity
US7213347B2 (en) * 2005-05-03 2007-05-08 Eastman Kodak Company Metering material to promote rapid vaporization
CN101184522B (en) 2005-05-18 2011-12-21 尼克塔治疗公司 Valves, devices, and methods for endobronchial therapy
EP1733753A1 (en) * 2005-06-14 2006-12-20 RIZK, Nelly Kamel An apparatus containing a composition
RU2408368C2 (en) 2005-06-27 2011-01-10 Биовэйл Лэборэториз Интернэшнл С.Р.Л. Modified release bupropion salt preparations
WO2007011030A1 (en) * 2005-07-21 2007-01-25 National Institute For Materials Science Device for inhalation of medicine
WO2007024812A1 (en) * 2005-08-23 2007-03-01 Aerogen, Inc. Self-sealing t-piece and valved t-piece
WO2008048234A2 (en) * 2005-08-26 2008-04-24 North Carolina State University Inhaler system for targeted maximum drug-aerosol delivery
EP1937217A2 (en) * 2005-09-13 2008-07-02 Elan Pharma International Limited Nanoparticulate tadalafil formulations
FR2891435B1 (en) * 2005-09-23 2007-11-09 Bull Sa Sa HOLDING SYSTEM IN POSITION OF A THREE-PART ASSEMBLY PROVIDING A PREDETERMINAL COMPRESSION EFFORT ON THE INTERMEDIATE PART
WO2007079118A1 (en) * 2005-12-29 2007-07-12 Molex Incorporated Heating element connector assembly with press-fit terminals
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8252328B2 (en) 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9289583B2 (en) 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US9066847B2 (en) 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US20070260491A1 (en) * 2006-05-08 2007-11-08 Pamela Palmer System for delivery and monitoring of administration of controlled substances
PE20080329A1 (en) * 2006-06-07 2008-04-09 Wyeth Corp TREATMENT OF CYST FIBROSIS WITH ANTIBIOTICS VIA A DRUG IN AEROSOL
US20070286818A1 (en) * 2006-06-07 2007-12-13 Wyeth Treating cystic fibrosis with antibiotics via an aerosol drug
CN101489686A (en) 2006-06-09 2009-07-22 菲利普莫里斯生产公司 Indirectly heated capillary aerosol generator
US20070299687A1 (en) * 2006-06-23 2007-12-27 Pamela Palmer Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed
BRPI0715328A2 (en) * 2006-08-04 2013-07-09 Insys Therapeutics Inc formulation and unit dose or multiple dose device for sublingual administration of a drug
US20090054333A1 (en) * 2006-10-17 2009-02-26 Antonio Giordano Peptide inhibitors of cyclin-dependent kinase activity and uses thereof
WO2008073757A1 (en) * 2006-12-07 2008-06-19 Helsinn Healthcare Sa Crystalline and amorphous forms of palonosetron hydrochloride
US20080299048A1 (en) * 2006-12-22 2008-12-04 Alexza Pharmaceuticals, Inc. Mixed drug aerosol compositions
US7513781B2 (en) 2006-12-27 2009-04-07 Molex Incorporated Heating element connector assembly with insert molded strips
EP1964564A1 (en) * 2007-04-19 2008-09-03 LAB International SRL Breakthrough Pain Management
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
EP2184983A1 (en) * 2007-08-06 2010-05-19 Insys Therapeutics Inc. Oral cannabinoid liquid formulations and methods of treatment
CN101820838B (en) * 2007-08-07 2013-06-05 阿塞尔Rx制药有限公司 Compositions and methods for procedural sedation and analgesia using oral transmucosal dosage forms
AU2008310734B2 (en) 2007-10-10 2014-06-05 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
WO2009079078A1 (en) 2007-12-14 2009-06-25 Labogroup S.A.S. Delivering aerosolizable food products
CN102014927A (en) 2008-03-06 2011-04-13 安纳考尔医药公司 Boron-containing small molecules as anti-inflammatory agents
EA022565B1 (en) * 2008-05-27 2016-01-29 Дзе Юниверсити Оф Мельбурн Methods of treating mammals with eustachian tube dysfunctions
US7834295B2 (en) * 2008-09-16 2010-11-16 Alexza Pharmaceuticals, Inc. Printable igniters
US20100065052A1 (en) * 2008-09-16 2010-03-18 Alexza Pharmaceuticals, Inc. Heating Units
AU2009292643B2 (en) * 2008-09-19 2016-02-18 Nektar Therapeutics Polymer conjugates of therapeutic peptides
EP2344200A2 (en) * 2008-09-19 2011-07-20 Nektar Therapeutics Modified therapeutics peptides, methods of their preparation and use
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
EP2370136A4 (en) * 2008-12-01 2015-12-30 Map Pharmaceuticals Inc Inhalation delivery methods and devices
WO2010074753A1 (en) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US8548623B2 (en) 2009-03-18 2013-10-01 Acelrx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US20100300433A1 (en) * 2009-05-28 2010-12-02 Alexza Pharmaceuticals, Inc. Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol
CN201445686U (en) * 2009-06-19 2010-05-05 李文博 High-frequency induction atomizing device
US8488952B2 (en) * 2009-06-22 2013-07-16 Magic-Flight General Manufacturing, Inc. Aromatic vaporizer
US9180263B2 (en) * 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
WO2011009133A1 (en) * 2009-07-17 2011-01-20 Nektar Therapeutics Systems and methods for driving sealed nebulizers
WO2011014562A1 (en) 2009-07-28 2011-02-03 North Carolina State University Methods and devices for targeted injection of microspheres
CN102596264B (en) 2009-10-13 2016-09-07 菲利普莫里斯生产公司 Air freshening device
US20110091544A1 (en) * 2009-10-16 2011-04-21 Acelrx Pharmaceuticals, Inc. Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting
WO2011094450A1 (en) 2010-01-27 2011-08-04 Anacor Pharmaceuticals, Inc Boron-containing small molecules
WO2011112531A2 (en) * 2010-03-08 2011-09-15 Stc. Unm Dry powder nebulizer
CN102009012B (en) * 2010-03-31 2012-10-24 范维林 Liquid atomized aerosol generating device with temperature control
US11247003B2 (en) 2010-08-23 2022-02-15 Darren Rubin Systems and methods of aerosol delivery with airflow regulation
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
ES2898695T3 (en) 2010-09-07 2022-03-08 Anacor Pharmaceuticals Inc Benzoxaborole derivatives for the treatment of bacterial infections
EP3834869A1 (en) 2010-12-22 2021-06-16 Syqe Medical Ltd. System for drug delivery
JP6219271B2 (en) 2011-06-07 2017-10-25 パリオン・サイエンシィズ・インコーポレーテッド Method of treatment
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
UA110852C2 (en) * 2011-08-19 2016-02-25 Джапан Тобакко Інк. Aerosol inhaler
JP5808490B2 (en) 2011-09-06 2015-11-10 ブリティッシュ アメリカン タバコ （インヴェストメンツ） リミテッドＢｒｉｔｉｓｈ Ａｍｅｒｉｃａｎｔｏｂａｃｃｏ （Ｉｎｖｅｓｔｍｅｎｔｓ） Ｌｉｍｉｔｅｄ Smoking material heating
US9326547B2 (en) 2012-01-31 2016-05-03 Altria Client Services Llc Electronic vaping article
ES2619959T3 (en) * 2012-03-09 2017-06-27 Vectura Gmbh Mixing channel for an inhalation device and inhalation device
IN2014MN02064A (en) 2012-03-19 2015-08-21 Michael Klein
GB201217067D0 (en) 2012-09-25 2012-11-07 British American Tobacco Co Heating smokable material
SG11201504008PA (en) * 2012-11-28 2015-06-29 Nicotine Technology Inc E Methods and devices for compound delivery
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
MX2015009268A (en) * 2013-01-18 2015-12-07 Tonix Pharmaceuticals Inc Isometheptene isomer.
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
CA2882405C (en) 2013-03-15 2019-12-03 Trudell Medical International Ventilator circuit, adapter for use in ventilator circuit and methods for the use thereof
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
GB2515992A (en) 2013-03-22 2015-01-14 British American Tobacco Co Heating smokeable material
CN117137195A (en) 2013-05-06 2023-12-01 尤尔实验室有限公司 Nicotine salt formulations for aerosol devices and methods thereof
US11202470B2 (en) 2013-05-22 2021-12-21 Njoy, Inc. Compositions, devices, and methods for nicotine aerosol delivery
CN104274426A (en) 2013-07-03 2015-01-14 陆克塞纳医药公司 Novel aerosol formulations of ondansetron and uses thereof
WO2016004409A1 (en) * 2014-07-03 2016-01-07 Luxena Pharmaceuticals, Inc. Novel aerosol formulations of ondansetron and uses thereof
US10010692B2 (en) * 2013-07-08 2018-07-03 Virginia Commonwealth University Systems, devices, and methods for changing therapeutic aerosol size and improving efficiency of ventilation and aerosol drug delivery
JP6397493B2 (en) 2013-07-11 2018-09-26 アレックザ ファーマシューティカルズ， インコーポレイテッド Nicotine salt with meta-salicylic acid
DE202013105715U1 (en) 2013-08-22 2014-02-19 Sipnose Ltd. Device for delivering a predetermined amount of a substance to a natural opening of the body
US11278682B2 (en) 2014-11-09 2022-03-22 Sipnose Ltd. Device and method for aerosolized delivery of substance to a natural orifice of the body
US11116914B2 (en) 2014-11-09 2021-09-14 Sipnose Ltd. Device and method for aerosolized delivering of substance to a natural orifice of the body
US11471618B2 (en) 2014-11-09 2022-10-18 Sipnose Ltd. Adjustable dosing delivery and multi sectioned drug compartment
US10194693B2 (en) 2013-09-20 2019-02-05 Fontem Holdings 1 B.V. Aerosol generating device
US10980273B2 (en) 2013-11-12 2021-04-20 VMR Products, LLC Vaporizer, charger and methods of use
US10039321B2 (en) 2013-11-12 2018-08-07 Vmr Products Llc Vaporizer
EP3068244A4 (en) 2013-11-15 2017-07-05 VMR Products, LLC Vaporizer with cover sleeve
KR102471383B1 (en) 2013-12-05 2022-11-25 쥴 랩스, 인크. Nicotine liquid formulations for aerosol devices and methods thereof
EP3082428A4 (en) 2013-12-09 2017-08-02 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
WO2015095644A1 (en) 2013-12-20 2015-06-25 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
CN104740737A (en) * 2013-12-26 2015-07-01 北京谊安医疗系统股份有限公司 Anesthesia machine and heating device of absorption loop of anesthesia machine
CN105934168B (en) * 2014-02-10 2019-08-30 菲利普莫里斯生产公司 Aerosol with fluid penetrable heater assembly generates system
US10821240B2 (en) 2014-02-11 2020-11-03 Vapor Cartridge Technology Llc Methods and drug delivery devices using cannabis
US9220294B2 (en) 2014-02-11 2015-12-29 Timothy McCullough Methods and devices using cannabis vapors
US9380813B2 (en) 2014-02-11 2016-07-05 Timothy McCullough Drug delivery system and method
USD763502S1 (en) 2014-03-04 2016-08-09 Vmr Products Llc Cartomizer for a vaporizer
USD788697S1 (en) 2014-03-04 2017-06-06 VMR Products, LLC Battery portion for a vaporizer
USD752280S1 (en) 2014-03-07 2016-03-22 VMR Products, LLC Cartomizer for a vaporizer
USD752278S1 (en) 2014-03-07 2016-03-22 VMR Products, LLC Battery portion of a vaporizer
USD749505S1 (en) 2014-03-07 2016-02-16 VMR Products, LLC Charger for a vaporizer
TWI589308B (en) * 2014-03-25 2017-07-01 林信湧 Inhalation-type pharmaceutical composition for parkinson's disease and preparation method thereof
USD804090S1 (en) 2014-04-08 2017-11-28 VMR Products, LLC Vaporizer with indicators
USD750320S1 (en) 2014-08-05 2016-02-23 VMR Products, LLC Vaporizer
TWI669072B (en) 2014-05-21 2019-08-21 瑞士商菲利浦莫里斯製品股份有限公司 Electrically heated aerosol-generating system and cartridge for use in such a system
TWI661782B (en) 2014-05-21 2019-06-11 瑞士商菲利浦莫里斯製品股份有限公司 Electrically heated aerosol-generating system,electrically heated aerosol-generating deviceand method of generating an aerosol
KR101667177B1 (en) 2014-05-21 2016-10-24 필립모리스 프로덕츠 에스.에이. Aerosol-generating article with multi-material susceptor
GB201410562D0 (en) 2014-06-13 2014-07-30 Nicoventures Holdings Ltd Aerosol provision system
US10610512B2 (en) 2014-06-26 2020-04-07 Island Breeze Systems Ca, Llc MDI related products and methods of use
MX2017000056A (en) 2014-06-30 2017-06-30 Syqe Medical Ltd Flow regulating inhaler device.
PL3160552T3 (en) 2014-06-30 2020-03-31 Syqe Medical Ltd. Drug dose cartridge for an inhaler device
US11298477B2 (en) 2014-06-30 2022-04-12 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
MX2017000057A (en) 2014-06-30 2017-06-30 Syqe Medical Ltd Method and device for vaporization and inhalation of isolated substances.
WO2016001924A2 (en) 2014-06-30 2016-01-07 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
WO2016001922A1 (en) 2014-06-30 2016-01-07 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
CN104122179B (en) * 2014-08-05 2017-03-22 云南中烟工业有限责任公司 Method for evaluating smoke volume of electronic cigarettes
US11578863B2 (en) 2014-10-15 2023-02-14 Altria Client Services Llc Electronic vaping device and components thereof
MY187877A (en) 2014-12-23 2021-10-26 Acelrx Pharmaceuticals Inc Systems, devices and methods for dispensing oral transmucosal dosage forms
GB201423317D0 (en) 2014-12-29 2015-02-11 British American Tobacco Co Apparatus for heating smokable material
GB201423312D0 (en) 2014-12-29 2015-02-11 British American Tobacco Co Heating device for apparatus for heating smokable material and method of manufacture
GB201423318D0 (en) 2014-12-29 2015-02-11 British American Tobacco Co Cartridge for use with apparatus for heating smokable material
US10117462B2 (en) * 2015-02-02 2018-11-06 Intrepid Brands, LLC Personal electronic vaporizer
WO2017100369A1 (en) * 2015-12-07 2017-06-15 Ebbu, LLC Printable cannabinoid and terpene compositions
US20160250270A1 (en) * 2015-02-27 2016-09-01 Ebbu, LLC Compositions comprising combinations of purified cannabinoids, with at least one flavonoid, terpene, or mineral
CN114522152A (en) 2015-03-11 2022-05-24 艾利斯达医药品公司 Use of antistatic materials in airways for hot aerosol condensation processes
GB201511358D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
GB201511349D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
US10994084B2 (en) 2015-06-30 2021-05-04 Maury D. Cole Substance inhalation system and method
US9943388B2 (en) 2015-06-30 2018-04-17 Maury D. Cole Substance inhalation system and method
US10034857B2 (en) 2015-07-02 2018-07-31 Civitas Therapeutics, Inc. Triptan powders for pulmonary delivery
US20170038184A1 (en) * 2015-08-06 2017-02-09 Charles E. Ankner Formulation delivery system
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US20170055575A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US20170055574A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Cartridge for use with apparatus for heating smokable material
US20170119050A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Article for Use with Apparatus for Heating Smokable Material
US20170119051A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Article for Use with Apparatus for Heating Smokable Material
US20170119047A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Article for Use with Apparatus for Heating Smokable Material
US20170119046A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Apparatus for Heating Smokable Material
EP3399972B1 (en) * 2016-01-06 2021-03-31 Syqe Medical Ltd. Low dose therapeutic treatment
IL309606A (en) * 2016-01-11 2024-02-01 Syqe Medical Ltd Personal vaporizing device
WO2017136856A1 (en) * 2016-02-07 2017-08-10 U.S. Government As Represented By The Secretary Of The Army Oro-nasal inhalation plethysmography mask exposure system
WO2017153827A1 (en) 2016-03-07 2017-09-14 Wallbrooke Investments Ltd. Inductive heating apparatus and related method
US10244795B2 (en) * 2016-03-31 2019-04-02 Altria Client Services Llc Vaporizing assembly comprising sheet heating element and liquid delivery device for an aerosol generating system
KR102435122B1 (en) * 2016-03-31 2022-08-23 필립모리스 프로덕츠 에스.에이. A vaporization assembly for an aerosol-generating system comprising a seat heating element and a liquid delivery device
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
KR102122887B1 (en) * 2016-05-03 2020-06-16 뉴마 레스퍼러토리 인코포레이티드 Droplet delivery device and method of use for delivery of fluids to the waste relationship
US11457664B2 (en) 2016-06-29 2022-10-04 Nicoventures Trading Limited Apparatus for heating smokable material
CA3034004C (en) 2016-08-29 2021-08-03 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
WO2018102696A1 (en) 2016-12-02 2018-06-07 Vmr Products Llc Vaporizer
SI3551189T1 (en) 2016-12-09 2024-03-29 Alexza Pharmaceuticals, Inc. Alprazolam for use in treating epilepsy
US10231961B1 (en) 2017-02-07 2019-03-19 Genus Lifesciences Inc. Pharmaceutical compositions and methods of using the same
US10149843B1 (en) 2017-02-07 2018-12-11 Gneus Lifescineces Inc. Pharmaceutical compositions and methods of using the same
US10413505B1 (en) 2017-02-07 2019-09-17 Genus Lifesciences Inc. Pharmaceutical compositions and methods of using the same
ES2942889T3 (en) 2017-03-13 2023-06-07 Beyondspring Pharmaceuticals Inc Plinabulin compositions and use thereof
US11529476B2 (en) 2017-05-19 2022-12-20 Pneuma Respiratory, Inc. Dry powder delivery device and methods of use
TWI760513B (en) 2017-06-30 2022-04-11 瑞士商菲利浦莫里斯製品股份有限公司 Aerosol-generating device and aerosol-generating system with inductive heating system with efficient power control
US10292436B2 (en) 2017-07-10 2019-05-21 Arc Innovations, Inc. Electronic smoking systems, devices, and methods
US10506830B2 (en) 2017-09-22 2019-12-17 Altria Client Services Llc Air flow design for an e-vaping cartridge, method of making the e-vaping cartridge, and e-vaping device including the cartridge
EP4111951A1 (en) * 2017-10-02 2023-01-04 Lightlab Imaging, Inc. Intravascular data collection probes and related assemblies
JP2020536614A (en) 2017-10-04 2020-12-17 ニューマ・リスパイラトリー・インコーポレイテッド In-line droplet delivery device and usage that is electrically operated by breathing
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
CN111479604B (en) 2017-11-08 2022-12-30 精呼吸股份有限公司 Electrically breath actuated in-line droplet delivery device with small volume ampoule and method of use
KR20200118081A (en) * 2018-02-02 2020-10-14 알렉스자 파마스티칼즈, 인크. Electrical condensing aerosol device
EP3793655A4 (en) * 2018-05-17 2022-04-06 Sipnose Ltd Device and method for aerosolized delivery of substance to a natural orifice of the body
US11260195B2 (en) * 2018-09-20 2022-03-01 General Electric Company Systems and methods for an inductively heated anesthetic vaporizer
KR20210087963A (en) 2018-11-05 2021-07-13 쥴 랩스, 인크. Cartridge for carburetor device
US11464921B2 (en) 2018-11-05 2022-10-11 Juul Labs, Inc. Cartridges for vaporizer devices
HUE063731T2 (en) 2018-12-17 2024-01-28 Philip Morris Products Sa 3-(1,2,3,6-tetrahydropyridin-2-yl)pyridine glutarate or a pharmaceutically acceptable solvate thereof
CA3125791A1 (en) * 2019-01-07 2020-07-16 Fritz Schmitt Method for qualitative and/or quantitative detection of substances contained in a hemp plant and kit for use therein
CA3130406A1 (en) 2019-02-22 2020-08-27 Theis Terwey 5-methoxy-n,n-dimethyltryptamine (5-meo-dmt) for treating depression
CN109876252A (en) * 2019-04-04 2019-06-14 林晓霞 A kind of fixed atomizing inhalation device for paediatric internal medicine
CN113993523A (en) 2019-04-17 2022-01-28 指南针探路者有限公司 Treatment of depression and other various disorders with siloxibin
US11497249B2 (en) 2019-09-16 2022-11-15 Vapor Cartridge Technology Llc Drug delivery system with stackable substrates
EP3868364A1 (en) 2020-02-24 2021-08-25 GH Research Limited Aerosol comprising 5-methoxy-n,n-dimethyltryptamine
US11666553B2 (en) 2020-02-25 2023-06-06 North Cell Pharmceticals Inc. Method of reducing anxiety in non-human mammals by increasing brain serotonin levels
CN116940351A (en) * 2021-01-15 2023-10-24 阿奎斯蒂弗医疗股份有限公司 Prodrug compositions and methods of treatment
WO2022271848A1 (en) 2021-06-22 2022-12-29 Pneuma Respiratory, Inc. Droplet delivery device with push ejection
RU209490U1 (en) * 2021-07-05 2022-03-16 Общество с ограниченной ответственностью "ИнертГаз Медикал" Universal inhalation device for inert gas therapy with the function of heating the gas mixture
EP4159192A1 (en) 2021-09-30 2023-04-05 Biomind Labs Inc Dimethyltriptamine-based nasal spray for the personalised treatment of neurological and psychiatric disorders
CN114028595B (en) * 2021-10-28 2023-09-19 武汉生物制品研究所有限责任公司 Novel disinfection and evaluation method for coronavirus aerosol exposure system
CN113876748A (en) * 2021-11-22 2022-01-04 兆科药业（广州）有限公司 Atomization method of treprostinil aerosol inhalant for treating pulmonary hypertension
WO2023186797A1 (en) 2022-03-27 2023-10-05 GH Research Ireland Limited 5-meo-dmt for use in the treatment of sleep disturbance

Family Cites Families (555)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3080624A (en) * 1963-03-12 weber iii
US1864980A (en) 1932-06-28 Vapobizeb
US2243669A (en) * 1941-05-27 Electrical vaporizer
US1803334A (en) * 1931-05-05 Ootthujp lehmann
US1239634A (en) 1916-07-25 1917-09-11 Frank J Stuart Medical appliance.
US1535486A (en) * 1922-08-28 1925-04-28 James W Lundy Electric-lamp bulb
US2086140A (en) 1933-09-08 1937-07-06 Silten Ernst Automatic temperature regulated narcosis apparatus
US2084299A (en) 1934-12-15 1937-06-15 Arthur G Borden Medicament holder for nasal inhalers
US2230754A (en) 1937-02-15 1941-02-04 Bilhuber Corp E Unsaturated ethylamine derivatives
US2230753A (en) 1937-02-15 1941-02-04 Bilhuber Corp E Unsaturated ethylamine derivatives
GB502761A (en) 1938-01-29 1939-03-24 Christopher Engelbreth Improvements in and relating to hand inhalation apparatus
US2309846A (en) * 1941-03-06 1943-02-02 Holm Einar Marius Inhaler
FR921852A (en) 1945-12-06 1947-05-21 Diffuser of volatile products
US2469656A (en) * 1946-04-19 1949-05-10 Peter H Lienert Vaporizer
US2714649A (en) 1952-11-25 1955-08-02 Lyle H Critzer Vaporizer
US2761055A (en) 1953-06-10 1956-08-28 Malcome Van Ike Lamp-heated vaporizer
US2741812A (en) * 1954-02-15 1956-04-17 Tellier Andre Perfume dispenser
US2902484A (en) 1954-04-27 1959-09-01 Rhone Poulenc Sa Phenthiazine derivatives and processes for their preparation
US2887106A (en) * 1956-09-27 1959-05-19 Robinson Joseph Combined vaporizer and cover for medicament jar
US2898649A (en) 1956-11-19 1959-08-11 Elaine T Cassidy Perfume diffuser
US3371085A (en) 1959-12-10 1968-02-27 Hoffmann La Roche 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
US3043977A (en) 1960-03-30 1962-07-10 Puritron Corp Device and method for producing negative ions
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB903866A (en) 1961-05-09 1962-08-22 Dausse Lab Therapeutic preparations containing 7-substituted theophylline derivatives
NL284196A (en) * 1961-10-10
US3299185A (en) 1962-09-27 1967-01-17 Ube Nitto Kasei Co Dyeable polyolefin fibers containing a binary copolymer of styrene and acrylonitrile
US3169095A (en) * 1962-10-30 1965-02-09 Rexall Drug Chemical Self-propelling powder-dispensing compositions
BE629985A (en) 1962-11-29
GB1063512A (en) * 1962-11-30 1967-03-30 Benger Lab Ltd Aerosols
US3282729A (en) 1963-02-27 1966-11-01 Union Carbide Corp Barrier coated thermoplastic olefin polymer substrates
US3200819A (en) 1963-04-17 1965-08-17 Herbert A Gilbert Smokeless non-tobacco cigarette
NL298071A (en) 1963-06-04
IL26896A (en) 1966-01-19 1970-11-30 Endo Lab 14-hydroxynormorphines and 14-hydroxynormorphinones
US3909463A (en) 1968-11-29 1975-09-30 Allied Chem Grafted block copolymers of synthetic rubbers and polyolefins
US3987052A (en) 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
US4008723A (en) 1970-03-23 1977-02-22 Imperial Chemical Industries Limited Smoking mixture
US3863347A (en) * 1970-04-13 1975-02-04 Philip Michael Banner Navigation device
US3773955A (en) 1970-08-03 1973-11-20 Bristol Myers Co Analgetic compositions
US3831606A (en) 1971-02-19 1974-08-27 Alza Corp Auto inhaler
US3847650A (en) 1971-09-09 1974-11-12 Airco Inc Flashlamp with improved combustion foil and method of making same
US3749547A (en) 1971-09-09 1973-07-31 Airco Inc Flashlamp with improved combustible foil
US4166087A (en) 1971-11-22 1979-08-28 Cline-Buckner, Inc. Automatic intermittent vapor dispenser
US3701782A (en) 1972-02-10 1972-10-31 Upjohn Co 1-carbolower alkoxy - 6 - phenyl-4h-s-triazolo(1,4)benzodiazepine compounds
US3763347A (en) 1972-04-13 1973-10-02 Ncr Co Vaporous lamp
IE37524B1 (en) 1972-04-20 1977-08-17 Gallaher Ltd Synthetic smoking product
USRE30285E (en) 1972-05-22 1980-05-27 Spraying devices, in particular nebulizing devices
US3864326A (en) 1972-05-22 1975-02-04 Robert S Babington Spraying devices, in particular nebulizing devices
GB1366041A (en) 1972-07-21 1974-09-11 Kodama Bros Co Ltd Device for volatilizing insecticides and the like
US3773995A (en) 1972-10-27 1973-11-20 Westinghouse Electric Corp Motor advanced spring charging pawl and ratchet mechanism with spring assist
US3949743A (en) * 1973-03-19 1976-04-13 Schick Incorporated Medicated vapor production method and apparatus
US3930796A (en) * 1973-09-13 1976-01-06 Universal Oil Products Company Catalytic fume control device
US3982095A (en) 1973-10-04 1976-09-21 Searle Cardio-Pulmonary Systems Inc. Respiratory humidifier
US3971377A (en) 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
US3894040A (en) 1974-09-16 1975-07-08 American Home Prod 2,5,6,7-Tetrahydro-3H-imidazo(1,2-D)(1,4)benzodiazepine-5,6-dicarboxylic acid esters
US4045156A (en) 1974-12-23 1977-08-30 Gte Sylvania Incorporated Photoflash lamp
US4020379A (en) * 1975-10-02 1977-04-26 Eg&G, Inc. Bulb-shaped flashtube with metal envelope
US4104210A (en) 1975-12-17 1978-08-01 Monsanto Company Thermoplastic compositions of high unsaturation diene rubber and polyolefin resin
US4121583A (en) 1976-07-13 1978-10-24 Wen Yuan Chen Method and apparatus for alleviating asthma attacks
US4286604A (en) 1976-10-05 1981-09-01 Gallaher Limited Smoking materials
US4079742A (en) 1976-10-20 1978-03-21 Philip Morris Incorporated Process for the manufacture of synthetic smoking materials
US4160765A (en) 1976-11-17 1979-07-10 Smithkline Corporation Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4141369A (en) 1977-01-24 1979-02-27 Burruss Robert P Noncombustion system for the utilization of tobacco and other smoking materials
US4184099A (en) * 1977-04-27 1980-01-15 International Flavors & Fragrances Inc. Composition for slow release of volatile ingredients at _high temperature; and article comprising same
DE2752384A1 (en) 1977-08-29 1979-03-15 Simes PHARMACEUTICAL PREPARATION BASED ON ANTY-RELEASE AGENTS AND INHIBITANTS OF BETA ADRENERGIC RECEPTORS
SE7812207L (en) 1977-12-01 1979-06-02 Welsh Nat School Med APPARATUS, PROCEDURE AND MANUFACTURED PRODUCTS FOR USE IN THE ADMINISTRATION OF ANTIHISTAMINES
US4183912A (en) * 1978-01-16 1980-01-15 American Home Products Corporation Inhalation therapy for relieving bronchial spasm using quaternary salts of promethazine
JPS54120065A (en) 1978-02-24 1979-09-18 Osaka Takeshi Stick for blind person
US4198200A (en) 1978-05-18 1980-04-15 Lord Corporation Damage-preventive coatings
US4284089A (en) 1978-10-02 1981-08-18 Ray Jon P Simulated smoking device
US4276243A (en) * 1978-12-08 1981-06-30 Western Electric Company, Inc. Vapor delivery control system and method
US4280629A (en) 1979-01-08 1981-07-28 Anchor Brush Company, Inc. Container for nail polish or the like
US4219031A (en) 1979-03-05 1980-08-26 Philip Morris Incorporated Smoking product having core of fibrillar carbonized matter
US4229931A (en) 1979-03-05 1980-10-28 Deere & Company Hydraulic height sensing system with cylinder by-pass
IL59407A (en) 1979-03-06 1983-12-30 Sanofi Sa Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them
US4654370A (en) 1979-03-12 1987-03-31 Abbott Laboratories Glyceryl valproates
US4251525A (en) 1979-05-25 1981-02-17 Smithkline Corporation 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
US4229447A (en) 1979-06-04 1980-10-21 American Home Products Corporation Intraoral methods of using benzodiazepines
US4340072A (en) 1979-11-16 1982-07-20 Imperial Group Limited Smokeable device
EP0039369B1 (en) 1980-05-02 1983-06-15 Schering Corporation Beclomethasone ester solvates, process for their preparation, and preparation of a formulation
US4391285A (en) 1980-05-09 1983-07-05 Philip Morris, Incorporated Smoking article
US4347855A (en) 1980-07-23 1982-09-07 Philip Morris Incorporated Method of making smoking articles
US4303083A (en) 1980-10-10 1981-12-01 Burruss Jr Robert P Device for evaporation and inhalation of volatile compounds and medications
US4376767A (en) 1981-01-02 1983-03-15 Merck & Co., Inc. Pyridylmethyl esters of selected bio-affecting carboxylic acids
US4346059A (en) 1981-03-03 1982-08-24 Donald Spector Aroma-generating lamp structure
DE3116951C2 (en) * 1981-04-29 1984-12-20 Drägerwerk AG, 2400 Lübeck Device for adding liquid anesthetics to the breathing gas to be supplied to the patient
JPS5876038A (en) 1981-10-28 1983-05-09 高森　正之 Evaporation apparatus of insecticide or aromatic agent
GB2122903B (en) 1982-06-22 1986-11-05 Masayuki Takamori Vaporizers for vaporisable substances and support media for substances usable therewith
DE3224849A1 (en) 1982-07-02 1984-01-05 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn STEAM INHALER
US4556539A (en) 1982-08-27 1985-12-03 Donald Spector Disc-playing aroma generator
US4508726A (en) * 1982-09-16 1985-04-02 The Upjohn Company Treatment of panic disorders with alprazolam
US4474191A (en) 1982-09-30 1984-10-02 Steiner Pierre G Tar-free smoking devices
EP0120968B1 (en) 1982-09-30 1988-06-29 Dainihon Jochugiku Co., Ltd. Apparatus for heat-volatilizing medicinal agent
US4753758A (en) 1983-05-19 1988-06-28 Intertech Resources Inc. Respiratory humidifier
US5038769A (en) 1983-06-29 1991-08-13 Krauser Robert S Method and apparatus for treating ailments
US4523589A (en) 1983-06-29 1985-06-18 Krauser Robert S Method and apparatus for treating ailments
DE3326089A1 (en) 1983-07-20 1985-02-07 Gödecke AG, 1000 Berlin INHALATION-INTENDED PHARMACEUTICAL FORM OF CALCIUM ANTAGONISTS
DE3476197D1 (en) 1983-08-01 1989-02-23 Mclean Hospital Corp Gaba esters and gaba analogue esters
US4588721A (en) * 1983-09-12 1986-05-13 The Upjohn Company Treatment of negative symptoms of schizophrenia
ATE44470T1 (en) 1983-11-08 1989-07-15 Bunnell Life Systems Inc HUMIDIFIER, ESPECIALLY FOR RESPIRATORY ASSISTANCE SYSTEMS.
FI68988C (en) * 1984-01-04 1985-12-10 Rauma Repola Oy FLISSIKT VARS SIKTKORG DELATS I TVAO KORGSEKTORER
GB8405190D0 (en) 1984-02-28 1984-04-04 British Petroleum Co Plc Thermoplastic elastomer composition
US4627963A (en) 1984-02-29 1986-12-09 Lad Technology, Inc. Heat activated dispenser and method of dispensing a vapor therefrom
US4683231A (en) 1984-03-02 1987-07-28 Research Foundation For Mental Hygiene, Inc. Method of preventing withdrawal symptoms associated with the cessation or reduction of tobacco smoking
DE3414640A1 (en) * 1984-04-18 1985-10-24 W. Schlafhorst & Co, 4050 Mönchengladbach ROTATIONAL SHAFT
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US4647428A (en) * 1984-06-04 1987-03-03 Gyulay Joseph M Air freshener method
US4755508A (en) 1984-06-26 1988-07-05 Merck & Co., Inc. Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin
US5067499A (en) 1984-09-14 1991-11-26 R. J. Reynolds Tobacco Company Smoking article
US4793365A (en) 1984-09-14 1988-12-27 R. J. Reynolds Tobacco Company Smoking article
US5042509A (en) 1984-09-14 1991-08-27 R. J. Reynolds Tobacco Company Method for making aerosol generating cartridge
US5020548A (en) 1985-08-26 1991-06-04 R. J. Reynolds Tobacco Company Smoking article with improved fuel element
US4854331A (en) 1984-09-14 1989-08-08 R. J. Reynolds Tobacco Company Smoking article
US4647433A (en) * 1984-10-01 1987-03-03 Donald Spector Long-life aroma-generating capsule
CN1018607B (en) 1984-12-21 1992-10-14 美国耳·杰·瑞诺兹烟草公司 Smoking article
GB8501015D0 (en) 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
US5119834A (en) 1985-04-15 1992-06-09 R. J. Reynolds Tobacco Company Smoking article with improved substrate
US4928714A (en) 1985-04-15 1990-05-29 R. J. Reynolds Tobacco Company Smoking article with embedded substrate
JPS63500175A (en) 1985-05-22 1988-01-21 リポソ−ム　テクノロジ−，インコ−ポレイテツド Liposome inhalation method and inhalation system
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
US4800903A (en) 1985-05-24 1989-01-31 Ray Jon P Nicotine dispenser with polymeric reservoir of nicotine
US4722334A (en) * 1985-07-16 1988-02-02 Transpirator Technologies, Inc. Method and apparatus for pulmonary and cardiovascular conditioning of racehorses and competition animals
US4989619A (en) 1985-08-26 1991-02-05 R. J. Reynolds Tobacco Company Smoking article with improved fuel element
US5105831A (en) 1985-10-23 1992-04-21 R. J. Reynolds Tobacco Company Smoking article with conductive aerosol chamber
US5060666A (en) 1985-10-28 1991-10-29 R. J. Reynolds Tobacco Company Smoking article with tobacco jacket
US5033483A (en) 1985-10-28 1991-07-23 R. J. Reynolds Tobacco Company Smoking article with tobacco jacket
US4756318A (en) 1985-10-28 1988-07-12 R. J. Reynolds Tobacco Company Smoking article with tobacco jacket
US4793366A (en) 1985-11-12 1988-12-27 Hill Ira D Nicotine dispensing device and methods of making the same
JPS62204756A (en) * 1986-03-04 1987-09-09 大研医工株式会社 Drug volatilizing method and apparatus
EP0259383B1 (en) 1986-03-10 1991-01-23 Kurt Dr. Burghart Pharmaceutical preparation and process for preparing the same
US4708151A (en) 1986-03-14 1987-11-24 R. J. Reynolds Tobacco Company Pipe with replaceable cartridge
US4765347A (en) 1986-05-09 1988-08-23 R. J. Reynolds Tobacco Company Aerosol flavor delivery system
US4771795A (en) 1986-05-15 1988-09-20 R. J. Reynolds Tobacco Company Smoking article with dual burn rate fuel element
US4917120A (en) 1986-05-21 1990-04-17 Advanced Tobacco Products, Inc. Nicotine impact modification
US4774971A (en) 1986-06-03 1988-10-04 Vieten Michael J Cigarette substitute
US4801411A (en) 1986-06-05 1989-01-31 Southwest Research Institute Method and apparatus for producing monosize ceramic particles
US4735217A (en) 1986-08-21 1988-04-05 The Procter & Gamble Company Dosing device to provide vaporized medicament to the lungs as a fine aerosol
US4858630A (en) 1986-12-08 1989-08-22 R. J. Reynolds Tobacco Company Smoking article with improved aerosol forming substrate
IE873108L (en) 1986-12-12 1988-06-12 Huels Chemische Werke Ag Impact modifying agent for use with smoking articles
US4734560A (en) 1987-01-20 1988-03-29 Medical Enterprises, Ltd. Vaporizing unit
US4819665A (en) 1987-01-23 1989-04-11 R. J. Reynolds Tobacco Company Aerosol delivery article
US4924883A (en) * 1987-03-06 1990-05-15 R. J. Reynolds Tobacco Company Smoking article
US4968885A (en) 1987-03-06 1990-11-06 Extrel Corporation Method and apparatus for introduction of liquid effluent into mass spectrometer and other gas-phase or particle detectors
HU201685B (en) 1987-04-23 1990-12-28 Chinoin Gyogyszer Es Vegyeszet For producing pharmaceutical compositions for inhalation and compositions for scenting air containing volatile active component in cyclodextrine inclusion, and air-scenting composition
US4889850A (en) 1987-05-11 1989-12-26 Thornfeldt Carl R Treatment of colic and teething
US5017575A (en) 1987-06-09 1991-05-21 Golwyn Daniel H Treatment of immunologically based disorders, specifically Crohn's disease
GB8713645D0 (en) 1987-06-11 1987-07-15 Imp Tobacco Ltd Smoking device
US5019122A (en) 1987-08-21 1991-05-28 R. J. Reynolds Tobacco Company Smoking article with an enclosed heat conductive capsule containing an aerosol forming substance
US4935624A (en) * 1987-09-30 1990-06-19 Cornell Research Foundation, Inc. Thermal-assisted electrospray interface (TAESI) for LC/MS
US5072726A (en) 1987-10-09 1991-12-17 University Of Pittsburgh Of The Commonwealth System Of Higher Education Vaporizer for inhalation anesthetics during high-frequency jet ventilation and associated method
US4911157A (en) * 1988-01-07 1990-03-27 Pegasus Research Corporation Self-regulating, heated nebulizer system
US4906417A (en) 1988-02-08 1990-03-06 Associated Mills Inc. Humidifier
JPH01221313A (en) 1988-02-29 1989-09-04 Hayashi Teruaki Sublimation-releasable medicine composition and releasing system thereof
US4853517A (en) 1988-03-28 1989-08-01 John G. Bowen Vaporizing unit
DE3815221C2 (en) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Use of a retinol and / or retinoic acid ester-containing pharmaceutical preparation for inhalation for acting on the mucous membranes of the tracheo-bronchial tract, including the lung alveoli
US5137034A (en) 1988-05-16 1992-08-11 R. J. Reynolds Tobacco Company Smoking article with improved means for delivering flavorants
US4881556A (en) 1988-06-06 1989-11-21 R. J. Reynolds Tobacco Company Low CO smoking article
US5264433A (en) 1988-07-07 1993-11-23 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
CH678151A5 (en) 1988-07-13 1991-08-15 Heinz Hermann Weick Self-medication nasal dispenser
US5345951A (en) 1988-07-22 1994-09-13 Philip Morris Incorporated Smoking article
US4852561A (en) 1988-07-27 1989-08-01 Sperry C R Inhalation device
US4947874A (en) 1988-09-08 1990-08-14 R. J. Reynolds Tobacco Company Smoking articles utilizing electrical energy
EP0358114A3 (en) 1988-09-08 1990-11-14 R.J. Reynolds Tobacco Company Aerosol delivery articles utilizing electrical energy
US4947875A (en) 1988-09-08 1990-08-14 R. J. Reynolds Tobacco Company Flavor delivery articles utilizing electrical energy
US4922901A (en) * 1988-09-08 1990-05-08 R. J. Reynolds Tobacco Company Drug delivery articles utilizing electrical energy
US4950664A (en) 1988-09-16 1990-08-21 Rugby-Darby Group Companies, Inc. Nasal administration of benzodiazepine hypnotics
USRE36744E (en) 1988-09-16 2000-06-20 Ribogene, Inc. Nasal administration of benzodiazepine hypnotics
US4963289A (en) 1988-09-19 1990-10-16 The United States Of America As Represented By The United States Department Of Energy Method for producing monodisperse aerosols
US4917830A (en) 1988-09-19 1990-04-17 The United States Of America As Represented By The United States Department Of Energy Monodisperse aerosol generator
US5511726A (en) 1988-09-23 1996-04-30 Battelle Memorial Institute Nebulizer device
HU200105B (en) 1988-10-04 1990-04-28 Ferenc Inkovics Electrically actuated inhaler of uniform medicine feeding
US4984158A (en) * 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
US4917119A (en) 1988-11-30 1990-04-17 R. J. Reynolds Tobacco Company Drug delivery article
US4906476A (en) 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US4959380A (en) 1988-12-19 1990-09-25 Wilson Jordan E Method of treating people to stop smoking and composition
US4881541A (en) 1988-12-21 1989-11-21 The Regents Of The University Of California Vaporizer for an anesthetic having a vapor pressure about one atmosphere
GB8900267D0 (en) 1989-01-06 1989-03-08 Riker Laboratories Inc Narcotic analgesic formulations and apparatus containing same
US4892109A (en) * 1989-03-08 1990-01-09 Brown & Williamson Tobacco Corporation Simulated smoking article
DE3908161A1 (en) 1989-03-13 1990-09-27 Bat Cigarettenfab Gmbh Smokable article
EP0470154B1 (en) 1989-04-28 1996-06-05 Riker Laboratories, Inc. Dry powder inhalation device
GB8909891D0 (en) 1989-04-28 1989-06-14 Riker Laboratories Inc Device
HUT60631A (en) 1989-05-05 1992-10-28 North Sydney Area Health Serv Process for producing pharmaceutical compositions suitable for increasing fertility
US4941483A (en) 1989-09-18 1990-07-17 R. J. Reynolds Tobacco Company Aerosol delivery article
US6048857A (en) 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
US6313176B1 (en) 1989-10-17 2001-11-06 Everett J. Ellinwood, Jr. Dosing method of administering deprenyl via intraoral administration or inhalation administration
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
US5408574A (en) * 1989-12-01 1995-04-18 Philip Morris Incorporated Flat ceramic heater having discrete heating zones
US5093894A (en) * 1989-12-01 1992-03-03 Philip Morris Incorporated Electrically-powered linear heating element
US5060671A (en) 1989-12-01 1991-10-29 Philip Morris Incorporated Flavor generating article
US5269327A (en) 1989-12-01 1993-12-14 Philip Morris Incorporated Electrical smoking article
US5144962A (en) 1989-12-01 1992-09-08 Philip Morris Incorporated Flavor-delivery article
US5224498A (en) 1989-12-01 1993-07-06 Philip Morris Incorporated Electrically-powered heating element
CA2070823C (en) 1989-12-05 1999-01-12 William H. Ii Frey Neurologic agents for nasal administration to the brain
US5109180A (en) * 1989-12-14 1992-04-28 Phillips Petroleum Company Apparatus providing a shatter-resistant electric lamp
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
GB9000042D0 (en) * 1990-01-03 1990-03-07 Ralph John F Decorative wall covering applied to steel radiators
GB2239807A (en) * 1990-01-09 1991-07-17 Boc Group Plc Anaesthetic vaporiser
US5376386A (en) 1990-01-24 1994-12-27 British Technology Group Limited Aerosol carriers
US5156170A (en) 1990-02-27 1992-10-20 R. J. Reynolds Tobacco Company Cigarette
US5099861A (en) 1990-02-27 1992-03-31 R. J. Reynolds Tobacco Company Aerosol delivery article
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
US5118494A (en) 1990-03-23 1992-06-02 Minnesota Mining And Manufacturing Company Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
US5366770A (en) 1990-04-17 1994-11-22 Xingwu Wang Aerosol-plasma deposition of films for electronic cells
US5229382A (en) 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US5192548A (en) 1990-04-30 1993-03-09 Riker Laboratoires, Inc. Device
WO1991018897A1 (en) 1990-06-07 1991-12-12 The Wellcome Foundation Limited Therapeutic heterocyclic compounds
US5167242A (en) 1990-06-08 1992-12-01 Kabi Pharmacia Aktiebolaq Nicotine-impermeable container and method of fabricating the same
SE9002052D0 (en) 1990-06-08 1990-06-08 Pharmacia Ab SMOKING COMPOSITION
US5455043A (en) 1990-06-13 1995-10-03 Fischel-Ghodsian; Fariba Device for controlled release of vaporous medications through nasal route
US5126123A (en) 1990-06-28 1992-06-30 Glaxo, Inc. Aerosol drug formulations
EP0469797B2 (en) * 1990-08-02 2001-12-12 Datex-Ohmeda Inc. Anaesthetic vaporiser
US5060667A (en) 1990-08-16 1991-10-29 Brown & Williamson Tobacco Corporation Smoking article
US5292499A (en) 1990-09-11 1994-03-08 University Of Wales College Of Cardiff Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
US5166202A (en) 1990-09-19 1992-11-24 Trustees Of The University Of Pennsylvania Method for the treatment of panic disorder
NO904226D0 (en) 1990-09-28 1990-09-28 Forsvarets Forsknings MOISTURE DEVICES.
US5175152A (en) 1990-09-28 1992-12-29 Singh Nikhilesh N Composition containing ephedrine base and alkyl salicylate for the delivery of ephedrine base in vapor form
US5179966A (en) * 1990-11-19 1993-01-19 Philip Morris Incorporated Flavor generating article
US5095921A (en) * 1990-11-19 1992-03-17 Philip Morris Incorporated Flavor generating article
HU219778B (en) 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Process for producing n-acyl-2,3-benzodiazepine derivatives, their acid additional salts and pharmaceutical compositions containing them and a grop of the compounds and pharmaceutical compositions containing them
US5519019A (en) 1990-12-21 1996-05-21 Gyogyszerkutato Intezet N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
FR2671487B1 (en) 1991-01-14 1993-03-19 Oreal USE OF A GROWTH FACTOR IN A SLIMMING COMPOSITION.
DE69229070T2 (en) * 1991-02-09 1999-11-18 B S D Bio Science Dev Snc Di O Antireactive anti-asthmatic effects of acetylsalicylic acid by inhalation
DE69430303T2 (en) 1991-03-05 2002-11-28 Aradigm Corp METHOD AND DEVICE FOR CORRECTING A ZERO SIGNAL OF A PRESSURE SENSOR FOR A FLOW METER
US5394866A (en) 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
US5404871A (en) 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5226411A (en) 1991-03-07 1993-07-13 Walter Levine Aerosol nebulizer heater
US5505214A (en) * 1991-03-11 1996-04-09 Philip Morris Incorporated Electrical smoking article and method for making same
US5479948A (en) * 1993-08-10 1996-01-02 Philip Morris Incorporated Electrical smoking article having continuous tobacco flavor web and flavor cassette therefor
US5249586A (en) 1991-03-11 1993-10-05 Philip Morris Incorporated Electrical smoking
US5186164A (en) * 1991-03-15 1993-02-16 Puthalath Raghuprasad Mist inhaler
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
US5605897A (en) 1991-04-23 1997-02-25 Eli Lilly And Company 2-methyl-thieno-benzodiazepine
US5817656A (en) 1991-04-23 1998-10-06 Eli Lilly And Company Mental disorders
US5627178A (en) 1991-04-23 1997-05-06 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US5164740A (en) 1991-04-24 1992-11-17 Yehuda Ivri High frequency printing mechanism
US5938117A (en) 1991-04-24 1999-08-17 Aerogen, Inc. Methods and apparatus for dispensing liquids as an atomized spray
GB9109021D0 (en) 1991-04-26 1991-06-12 Boc Group Plc Dosing pump
GB9109442D0 (en) * 1991-05-01 1991-06-26 Volex Group Plc Apparatus for emitting a chemical agent
US5261424A (en) 1991-05-31 1993-11-16 Philip Morris Incorporated Control device for flavor-generating article
US5160664A (en) * 1991-05-31 1992-11-03 Msp Corporation High output monodisperse aerosol generator
US5149538A (en) 1991-06-14 1992-09-22 Warner-Lambert Company Misuse-resistive transdermal opioid dosage form
US5177071A (en) 1991-06-17 1993-01-05 Merck & Co., Inc. 1,4-benzodiazepines with 6-membered heterocyclic rings to treat panic and anxiety disorder
US5285798A (en) * 1991-06-28 1994-02-15 R. J. Reynolds Tobacco Company Tobacco smoking article with electrochemical heat source
CA2069687A1 (en) * 1991-06-28 1992-12-29 Chandra Kumar Banerjee Tobacco smoking article with electrochemical heat source
CN1103609C (en) * 1991-08-07 2003-03-26 伊万·菲利普·吉勒·佩森蒂 Inhalation device
US5184133A (en) * 1991-11-26 1993-02-02 Texas Instruments Incorporated ISAR imaging radar system
US5457100A (en) 1991-12-02 1995-10-10 Daniel; David G. Method for treatment of recurrent paroxysmal neuropsychiatric
US5363842A (en) 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
GB9200047D0 (en) 1992-01-03 1992-02-26 Univ Alberta Nicotine-containing nasal spray
US5229120A (en) 1992-02-05 1993-07-20 Devincent James F Treatment for cocaine abuse
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
DK64592D0 (en) 1992-05-14 1992-05-14 Carlbiotech Ltd As PEPTIDES FOR THERAPEUTIC TREATMENT
US5584701A (en) 1992-05-13 1996-12-17 University Of Florida Research Foundation, Incorporated Self regulating lung for simulated medical procedures
US5391081A (en) 1992-05-13 1995-02-21 University Of Florida Research Foundation, Incorporated Method and apparatus for simulating neuromuscular stimulation during medical surgery
US5525329A (en) 1992-05-21 1996-06-11 The Johns Hopkins University Inhibition of phosphodiesterase in olfactory mucosa
ATE204750T1 (en) 1992-06-12 2001-09-15 Teijin Ltd PHARMACEUTICAL PREPARATION FOR USE IN THE RESPIRATORY CIRCULATION
US5607691A (en) 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US5622944A (en) 1992-06-12 1997-04-22 Affymax Technologies N.V. Testosterone prodrugs for improved drug delivery
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
US5322075A (en) 1992-09-10 1994-06-21 Philip Morris Incorporated Heater for an electric flavor-generating article
US5613505A (en) * 1992-09-11 1997-03-25 Philip Morris Incorporated Inductive heating systems for smoking articles
US5333106A (en) 1992-10-09 1994-07-26 Circadian, Inc. Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers
AU5358694A (en) 1992-10-28 1994-05-24 Charles A. Rosen Method and devices for delivering drugs by inhalation
US5970973A (en) 1993-01-29 1999-10-26 Aradigm Corporation Method of delivering insulin lispro
US6098620A (en) 1993-01-29 2000-08-08 Aradigm Corporation Device for aerosolizing narcotics
US5364838A (en) 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
US5915378A (en) 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US5672581A (en) 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US5724957A (en) 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics
US5934272A (en) 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5558085A (en) 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US5694919A (en) 1993-01-29 1997-12-09 Aradigm Corporation Lockout device for controlled release of drug from patient-activated dispenser
US5507277A (en) 1993-01-29 1996-04-16 Aradigm Corporation Lockout device for controlled release of drug from patient-activateddispenser
US5888477A (en) 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US6024090A (en) 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5743250A (en) 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5372148A (en) 1993-02-24 1994-12-13 Philip Morris Incorporated Method and apparatus for controlling the supply of energy to a heating load in a smoking article
US5468936A (en) 1993-03-23 1995-11-21 Philip Morris Incorporated Heater having a multiple-layer ceramic substrate and method of fabrication
GB9310412D0 (en) 1993-05-20 1993-07-07 Danbiosyst Uk Nasal nicotine system
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
CN1082365A (en) 1993-05-25 1994-02-23 潘昆年 Nutrient health-protecting cigarette
SK284063B6 (en) 1993-06-03 2004-09-08 Schrader Barthold Von Inhalator
US5666977A (en) 1993-06-10 1997-09-16 Philip Morris Incorporated Electrical smoking article using liquid tobacco flavor medium delivery system
KR100314138B1 (en) * 1993-06-29 2001-12-28 마틴 보게스 로버트 Metering device
US5388574A (en) * 1993-07-29 1995-02-14 Ingebrethsen; Bradley J. Aerosol delivery article
DE4328243C1 (en) 1993-08-19 1995-03-09 Sven Mielordt Smoke or inhalation device
US5456247A (en) 1993-08-26 1995-10-10 Iowa State University Research Foundation, Inc. Method for delivering drugs soluble in a vaporization vehicle
US5462740A (en) 1993-09-17 1995-10-31 Athena Neurosciences, Inc. Rectally-administered, epileptic-seizure-inhibiting composition
US5400969A (en) * 1993-09-20 1995-03-28 Keene; Christopher M. Liquid vaporizer and diffuser
SE9303574D0 (en) 1993-11-01 1993-11-01 Kabi Pharmacia Ab Composition for drug delivery and method of manufacturing thereof
FI98270C (en) 1993-11-29 1997-05-26 Instrumentarium Oy Method and apparatus for evaporation of anesthetic agent
MA23420A1 (en) 1994-01-07 1995-10-01 Smithkline Beecham Corp BICYCLIC FIBRINOGEN ANTAGONISTS.
US6143746A (en) 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
GB9401894D0 (en) 1994-02-01 1994-03-30 Rhone Poulenc Rorer Ltd New compositions of matter
US5543434A (en) 1994-02-25 1996-08-06 Weg; Stuart L. Nasal administration of ketamine to manage pain
US5522008A (en) 1994-03-16 1996-05-28 Bernard; Costello J. Device for heating and vaporizing a vaporizable module
US5451408A (en) 1994-03-23 1995-09-19 Liposome Pain Management, Ltd. Pain management with liposome-encapsulated analgesic drugs
CN1082365C (en) 1994-03-30 2002-04-10 普罗克特和甘保尔公司 Combined skin moisturizing and cleaning bar composition
US6102036A (en) 1994-04-12 2000-08-15 Smoke-Stop Breath activated inhaler
WO1995031182A1 (en) 1994-05-13 1995-11-23 Aradigm Corporation Narcotic containing aerosol formulation
US5457101A (en) 1994-06-03 1995-10-10 Eli Lilly And Company Thieno[1,5]benzoidiazepine use
AU2702795A (en) 1994-06-23 1996-01-19 Procter & Gamble Company, The Treatment of nicotine craving and/or smoking withdrawal symptoms with a solid or semi-solid composition containing nicotine and caffeine or xanthine, especially for nasal administration
MA23588A1 (en) 1994-06-23 1995-12-31 Procter & Gamble TREATMENT OF NEED FOR NICOTINE AND / OR SMOKING-RELATED SYNDROME
MA23587A1 (en) 1994-06-23 1995-12-31 Procter & Gamble TREATMENT OF NEED FOR NICOTINE AND / OR SMOKING-RELATED SYNDROME
CA2152684A1 (en) 1994-07-01 1996-01-02 Richard Anthony Henry Aerosol delivery of midazolam
DE4425255A1 (en) 1994-07-16 1996-01-18 Asta Medica Ag Formulation for inhalation application
EP0777657A1 (en) 1994-08-22 1997-06-11 Smithkline Beecham Corporation Bicyclic compounds
US5456677A (en) 1994-08-22 1995-10-10 Spector; John E. Method for oral spray administration of caffeine
US5522385A (en) 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5537507A (en) 1994-09-28 1996-07-16 Advanced Ceramics Corporation Coated flash evaporator heater
AU3380395A (en) 1994-09-30 1996-04-26 Niro Separation A/S A plant and a process for dry-producing a web-formed product
AU3745795A (en) 1994-10-14 1996-05-06 Glaxo Wellcome S.P.A. Use of CCK-B receptor antagonists for the treatment of sleepdisorders
EP1177807A3 (en) 1994-10-28 2003-10-22 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5767117A (en) * 1994-11-18 1998-06-16 The General Hospital Corporation Method for treating vascular headaches
US5540959A (en) 1995-02-21 1996-07-30 Howard J. Greenwald Process for preparing a coated substrate
US5747001A (en) 1995-02-24 1998-05-05 Nanosystems, L.L.C. Aerosols containing beclomethazone nanoparticle dispersions
AU4990696A (en) 1995-02-24 1996-09-11 Nanosystems L.L.C. Aerosols containing nanoparticle dispersions
DE19507410C2 (en) 1995-03-03 1997-05-22 Gsf Forschungszentrum Umwelt Method and device for producing aerosols
US5565148A (en) 1995-03-16 1996-10-15 Minnesota Mining And Manufacturing Company Device for selectively providing a multiplicity of aromas
JPH11502845A (en) 1995-03-31 1999-03-09 アラディグム コーポレーション Pulmonary delivery of hematopoietic agents
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6014970A (en) 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US5586550A (en) 1995-08-31 1996-12-24 Fluid Propulsion Technologies, Inc. Apparatus and methods for the delivery of therapeutic liquids to the respiratory system
US5612053A (en) * 1995-04-07 1997-03-18 Edward Mendell Co., Inc. Controlled release insufflation carrier for medicaments
US6258341B1 (en) 1995-04-14 2001-07-10 Inhale Therapeutic Systems, Inc. Stable glassy state powder formulations
WO1996032099A1 (en) 1995-04-14 1996-10-17 Glaxo Wellcome Inc. Metered dose inhaler for albuterol
RO119116B1 (en) 1995-04-14 2004-04-30 Glaxo Wellcome Inc. Inhaler for dosing salmeterol
AU718851B2 (en) 1995-04-14 2000-04-20 Smithkline Beecham Corporation Metered dose inhaler for beclomethasone dipropionate
US5690809A (en) 1995-04-18 1997-11-25 Center For Research, Inc. In situ mitigation of coke buildup in porous catalysts by pretreatment of hydrocarbon feed to reduce peroxides and oxygen impurities
US5725756A (en) 1995-04-18 1998-03-10 Center For Research, Inc. In situ mitigation of coke buildup in porous catalysts with supercritical reaction media
US5776928A (en) 1995-04-21 1998-07-07 Eli Lilly And Company Method for treating dyskinesias with olanzapine
FR2733594B1 (en) * 1995-04-28 1997-06-06 France Etat DEVICE FOR THE SAMPLING OF GASEOUS SUBSTANCES, LIQUIDS, AEROSOLS OR EVEN OF POWDERY MATERIALS, FOR THEIR IN SITU ANALYSIS
US5809997A (en) 1995-05-18 1998-09-22 Medtrac Technologies, Inc. Electronic medication chronolog device
DE19519056A1 (en) 1995-05-24 1997-01-16 Klinge Co Chem Pharm Fab Use of antidepressants for the treatment of asthma and / or respiratory diseases by inhalation
US5874481A (en) * 1995-06-07 1999-02-23 Alliance Pharmaceutical Corp. Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents
GB9512708D0 (en) 1995-06-22 1995-08-23 Reckitt & Colman Inc Improvements in or relating to organic compounds
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
US6209538B1 (en) * 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5591409A (en) * 1995-08-15 1997-01-07 Watkins; Carl J. Providing aromas
SE9503141D0 (en) 1995-09-12 1995-09-12 Siemens Elema Ab Anesthesia apparatus
US5649554A (en) 1995-10-16 1997-07-22 Philip Morris Incorporated Electrical lighter with a rotatable tobacco supply
US6013050A (en) 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
WO1997016181A1 (en) 1995-11-03 1997-05-09 University Of Kentucky Method for the intranasal administration of l-dopa prodrugs
US6017963A (en) 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
US5564442A (en) 1995-11-22 1996-10-15 Angus Collingwood MacDonald Battery powered nicotine vaporizer
US6041777A (en) * 1995-12-01 2000-03-28 Alliance Pharmaceutical Corp. Methods and apparatus for closed-circuit ventilation therapy
DE69632148T2 (en) 1995-12-14 2005-03-17 Taisho Pharmaceutical Co., Ltd. AEROSOL PREPARATION
SE9504580L (en) 1995-12-21 1997-06-22 Siemens Elema Ab Procedure for gasification of an anesthetic fluid and a carburetor
WO1997023221A1 (en) 1995-12-21 1997-07-03 Eli Lilly And Company Method for treating dermatitis
US5829436A (en) 1996-02-05 1998-11-03 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
EP0955885A1 (en) 1996-02-05 1999-11-17 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
DE19606107C1 (en) * 1996-02-19 1997-02-13 Martin Umwelt & Energietech Firing grate, in particular for waste incineration plants
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
GB9604329D0 (en) 1996-02-29 1996-05-01 Ici Plc Electrostatic spraying
US5833891A (en) 1996-10-09 1998-11-10 The University Of Kansas Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
EP0885038B1 (en) 1996-03-01 2011-06-15 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
EP0828489A4 (en) 1996-03-13 2001-04-04 Univ Yale Smoking cessation treatments using naltrexone and related compounds
GB9606188D0 (en) 1996-03-23 1996-05-29 Danbiosyst Uk Pollysaccharide microspheres for the pulmonary delivery of drugs
US5944012A (en) 1996-03-25 1999-08-31 Pera; Ivo E. Method for dispensing antioxidant vitamins by inhalation background of the invention
GB9606677D0 (en) 1996-03-29 1996-06-05 Glaxo Wellcome Inc Process and device
US5875776A (en) 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
GB2312848B (en) 1996-04-26 1999-11-17 Bespak Plc Controlled flow inhalers
JP2000510109A (en) 1996-04-29 2000-08-08 デュラ・ファーマシューティカルズ・インコーポレイテッド Inhalation method of dry powder
US5743251A (en) * 1996-05-15 1998-04-28 Philip Morris Incorporated Aerosol and a method and apparatus for generating an aerosol
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5929093A (en) 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
CN1106812C (en) * 1996-06-17 2003-04-30 日本烟业产业株式会社 Flavor producing article
EP0857431B1 (en) 1996-06-17 2003-03-12 Japan Tobacco Inc. Flavor generating product and flavor generating tool
GB9613015D0 (en) 1996-06-21 1996-08-28 Reckitt & Colman Inc Device
US6089857A (en) 1996-06-21 2000-07-18 Japan Tobacco, Inc. Heater for generating flavor and flavor generation appliance
AU3400797A (en) 1996-06-27 1998-01-14 Merck & Co., Inc. A method for treating meniere's disease
KR20000022239A (en) 1996-07-11 2000-04-25 토마스 헤인 Inclusion complex containing indole selective serotonin agonist
US6004516A (en) 1996-08-06 1999-12-21 Illinois Institute Of Technology Apparatus for generating odor upon electronic signal demand
US6325475B1 (en) 1996-09-06 2001-12-04 Microfab Technologies Inc. Devices for presenting airborne materials to the nose
US6048550A (en) 1996-10-03 2000-04-11 Chan; Daniel C. F. Hydrophilic microparticles and methods to prepare same
US5934289A (en) 1996-10-22 1999-08-10 Philip Morris Incorporated Electronic smoking system
US6694975B2 (en) * 1996-11-21 2004-02-24 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US6131570A (en) 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US5906202A (en) 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
US5878752A (en) 1996-11-25 1999-03-09 Philip Morris Incorporated Method and apparatus for using, cleaning, and maintaining electrical heat sources and lighters useful in smoking systems and other apparatuses
US5744469A (en) 1996-11-26 1998-04-28 Eli Lilly And Company Method for treating dermatitis
CA2222830C (en) * 1996-12-02 2004-03-30 Fisher & Paykel Limited Humidifier sleep apnea treatment apparatus
JP2001513078A (en) 1996-12-30 2001-08-28 バテル・メモリアル・インスティテュート Formulations and methods for treating neoplasms by inhalation
ATE287257T1 (en) 1997-01-16 2005-02-15 Massachusetts Inst Technology PREPARATION OF PARTICLE-CONTAINING MEDICINAL PRODUCTS FOR INHALATION
US6461591B1 (en) 1997-02-05 2002-10-08 Jago Research Ag Medical aerosol formulations
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US6051257A (en) 1997-02-24 2000-04-18 Superior Micropowders, Llc Powder batch of pharmaceutically-active particles and methods for making same
US5829435A (en) 1997-02-24 1998-11-03 Aradigm Corporation Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles
US6192882B1 (en) 1997-02-24 2001-02-27 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US5837713A (en) 1997-02-26 1998-11-17 Mayo Foundation For Medical Education And Research Treatment of eosinophil-associated pathologies by administration of topical anesthetics and glucocorticoids
HU219329B (en) 1997-04-21 2001-03-28 Radelkis Elektroanalitikai Mue Ph-electrode based on glass material
US5769621A (en) * 1997-05-23 1998-06-23 The Regents Of The University Of California Laser ablation based fuel ignition
US5907075A (en) 1997-06-11 1999-05-25 The University Of Kansas Solid acid supercritical alkylation reactions using carbon dioxide and/or other co-solvents
US5906811A (en) 1997-06-27 1999-05-25 Thione International, Inc. Intra-oral antioxidant preparations
US5928520A (en) 1997-07-16 1999-07-27 Abanaki Corporation Method and apparatus for extracting ground water contaiminants
KR100289448B1 (en) 1997-07-23 2001-05-02 미즈노 마사루 Flavor generator
HUP9701284A3 (en) 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
US5874841A (en) * 1997-07-28 1999-02-23 Philips Electronics North America Corporation Sample-and-hold circuit for a switched-mode power supply
US6090212A (en) * 1997-08-15 2000-07-18 Micro C Technologies, Inc. Substrate platform for a semiconductor substrate during rapid high temperature processing and method of supporting a substrate
US5855564A (en) 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
US6250301B1 (en) 1997-08-28 2001-06-26 Hortal Harm B.V. Vaporizer for inhalation and method for extraction of active ingredients from a crude natural product or other matrix
CN1176075A (en) 1997-08-29 1998-03-18 宋国合 Combustion-less innoxious cigarette and its preparation
US6138683A (en) 1997-09-19 2000-10-31 Thione International, Inc. Smokeless tobacco products containing antioxidants
EP1019023B1 (en) 1997-09-29 2003-05-07 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in nebulizers
US6390453B1 (en) 1997-10-22 2002-05-21 Microfab Technologies, Inc. Method and apparatus for delivery of fragrances and vapors to the nose
US6403597B1 (en) * 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
US6362178B1 (en) 1997-11-12 2002-03-26 Bayer Aktiengesellschaft 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
KR20010034406A (en) 1998-01-27 2001-04-25 아메리칸 사이아나미드 컴파니 2,3,4,5-Tetrahydro-1H[1,4]-benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors
US6044777A (en) 1998-02-09 2000-04-04 Walsh; Michael J. Composite metal safe and method of making
US6158431A (en) 1998-02-13 2000-12-12 Tsi Incorporated Portable systems and methods for delivery of therapeutic material to the pulmonary system
US5996589A (en) * 1998-03-03 1999-12-07 Brown & Williamson Tobacco Corporation Aerosol-delivery smoking article
CA2322805C (en) 1998-03-05 2005-09-13 Nippon Shinyaku Co., Ltd. Fat emulsions for inhalational administration
DE69927139T2 (en) 1998-03-05 2006-06-14 Zivena Inc pulmonary dosing
DE1073432T1 (en) 1998-04-14 2002-02-07 Gen Hospital Corp USE OF GLYCINE RECEPTORAGONISTS AND GLYCINE INHIBITOR INHIBITORS FOR THE TREATMENT OF NEUROPSYCHIATRIC COMPLAINTS
WO1999055362A1 (en) * 1998-04-29 1999-11-04 Genentech, Inc. Spray dried formulations of igf-i
GB9810559D0 (en) 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
US6060212A (en) * 1998-06-11 2000-05-09 Clariant Finance (Bvi) Limited 193 nm positive-working photoresist composition
AU4680699A (en) 1998-06-12 1999-12-30 Aradigm Corporation Methods of delivering aerosolized polynucleotides to the respiratory tract
US6095153A (en) 1998-06-19 2000-08-01 Kessler; Stephen B. Vaporization of volatile materials
TWI223598B (en) 1998-06-22 2004-11-11 Pfizer Ireland Pharmaceuticals An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
US6241969B1 (en) * 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
WO2000000215A1 (en) 1998-06-29 2000-01-06 Inhale Therapeutic Systems, Inc. Particulate delivery systems and methods of use
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
US6090403A (en) 1998-08-17 2000-07-18 Lectec Corporation Inhalation therapy decongestant with foraminous carrier
AU1200100A (en) 1998-10-02 2000-04-26 Battelle Memorial Institute Inhalation chemotherapy for prevention and treatment of metastatic tumors in thelung
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US6509005B1 (en) * 1998-10-27 2003-01-21 Virginia Commonwealth University Δ9 Tetrahydrocannabinol (Δ9 THC) solution metered dose inhaler
US6255334B1 (en) 1998-10-30 2001-07-03 Pfizer Inc 5HT 1 receptor agonists and metoclopramide for the treatment of migraine
MXPA01004828A (en) 1998-11-12 2002-09-18 Frank G Pilkiewicz An inhalation system.
DE19854012C2 (en) 1998-11-12 2001-05-10 Reemtsma H F & Ph Inhalable aerosol delivery system
DE19854007C2 (en) 1998-11-12 2001-05-17 Reemtsma H F & Ph Inhalable aerosol delivery system
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
DK1283036T3 (en) 1998-11-13 2008-03-25 Jagotec Ag Dry powder for inhalation
AU1473000A (en) 1998-11-16 2000-06-05 Aradigm Corporation Method of fabricating porous membrane with unique pore structure for aerosolizeddelivery of drugs
US6070575A (en) 1998-11-16 2000-06-06 Aradigm Corporation Aerosol-forming porous membrane with certain pore structure
US6113795A (en) 1998-11-17 2000-09-05 The University Of Kansas Process and apparatus for size selective separation of micro- and nano-particles
JP3506618B2 (en) 1998-11-18 2004-03-15 ウシオ電機株式会社 Incandescent light bulb for yellow light emission
ATE251447T1 (en) 1998-12-11 2003-10-15 Pharmachemie Bv PHARMACEUTICAL PREPARATIONS FOR INHALING AN OPIOID
WO2000038618A2 (en) 1998-12-24 2000-07-06 Du Pont Pharmaceuticals Company SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
AR022423A1 (en) 1999-01-27 2002-09-04 American Cyanamid Co COMPOUNDS DERIVED FROM ACIDS 2,3,4,5-TETRAHIDRO-1H- [1,4] BENZODIAZEPINA-3-HYDROXAMICS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM, AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
EP1031347B1 (en) 1999-01-27 2002-04-17 Idea Ag Transnasal transport/immunisation with highly adaptable carriers
US6376550B1 (en) * 1999-02-09 2002-04-23 Asta Medica Ag Pharmaceutical compositions containing tramadol for migraine
WO2000047203A1 (en) 1999-02-12 2000-08-17 Mqs, Inc. Formulation and system for intra-oral delivery of pharmaceutical agents
US6591839B2 (en) 1999-02-17 2003-07-15 Dieter Meyer Filter material for reducing harmful substances in tobacco smoke
US6053176A (en) * 1999-02-23 2000-04-25 Philip Morris Incorporated Heater and method for efficiently generating an aerosol from an indexing substrate
WO2000051491A1 (en) 1999-03-05 2000-09-08 Battelle Memorial Institute Method for safely and effectively administering a drug by inhalation
EP1173482A1 (en) 1999-04-27 2002-01-23 Eli Lilly And Company Insulin crystals for pulmonary administration
DE60042425D1 (en) 1999-04-30 2009-07-30 Univ Michigan Use of benzodiazepines for the treatment of autoimmune diseases, inflammation, neoplasia, viral infections and atherosclerosis
BR0010262A (en) 1999-05-03 2002-01-15 Battelle Memorial Institute Composition to form an aerosol, process for preparing and aerosolizing a composition, and aerosol generating device
US6428769B1 (en) 1999-05-04 2002-08-06 Aradigm Corporation Acute testosterone administration
US6309986B1 (en) 1999-05-07 2001-10-30 S. C. Johnson & Son, Inc. Mat for dispensing volatile materials
KR100883477B1 (en) 1999-05-27 2009-02-16 아쿠스피어 인코포레이티드. Pharmaceutical composition of porous drug matrices
EP1192009B1 (en) 1999-06-11 2013-05-01 Aradigm Corporation Method for producing an aerosol
US20020061281A1 (en) * 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
WO2001005459A1 (en) 1999-07-16 2001-01-25 Aradigm Corporation System for effecting smoke cessation
WO2001013957A2 (en) 1999-08-24 2001-03-01 Cellgate, Inc. Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
WO2001017614A2 (en) 1999-09-07 2001-03-15 Conjuchem, Inc. Methods and compositions containing succinimide or maleimide derivatives of antineoplastic agents
JP2003509142A (en) 1999-09-15 2003-03-11 アラダイム コーポレーション Reduced aerosol pore structure
CZ20021086A3 (en) * 1999-09-30 2002-10-16 Neurogen Corporation Alkylenediamine substituted heterocycles
CA2386974C (en) 1999-10-15 2009-10-13 Geo Adam Benzodiazepine derivatives for use in acute or chronic neurological disorders
IL149085A0 (en) 1999-10-29 2002-11-10 Inhale Therapeutic Syst A dry powder composition containing a di or tripeptide
CA2325106A1 (en) 1999-12-06 2001-06-06 Stanley L. Gore Compositions and methods for intranasal delivery of active agents to the brain
DE19961300A1 (en) 1999-12-18 2001-06-21 Asta Medica Ag Storage system for medicinal products in powder form and inhaler equipped with them
DE10001035A1 (en) * 2000-01-13 2001-07-26 Bayer Ag Active ingredient chip with integrated heating element
AU3400501A (en) 2000-02-28 2001-09-12 Vectura Ltd Improvements in or relating to the delivery of oral drugs
DE60139307D1 (en) * 2000-03-23 2009-09-03 Pmpi Llc ELECTRICAL SMOKE SYSTEM AND METHOD
US6632047B2 (en) 2000-04-14 2003-10-14 Board Of Regents, The University Of Texas System Heater element for use in an in situ thermal desorption soil remediation system
JP2001299916A (en) 2000-04-18 2001-10-30 Kao Corp Mask-shaped inhalator
MY136453A (en) * 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
CA2410577A1 (en) 2000-05-23 2001-12-13 The Trustees Of Columbia University In The City Of New York Method for treating respiratory disorders associated with pulmonary elastic fiber injury
WO2001095903A1 (en) 2000-06-15 2001-12-20 Respiratorius Ab 5-ht3 receptor antagonists for treatment of disorders involving airway constriction
GB0015981D0 (en) 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
FR2812545B1 (en) 2000-08-03 2003-03-28 Air Liquide Sante Int INHALABLE DRUG AEROSOL FOR TREATMENT OR PREVENTION OF SWEETNESS
US6514482B1 (en) * 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6613308B2 (en) * 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US20020117175A1 (en) 2000-10-27 2002-08-29 Kottayil S. George Thermal vaporizing device for drug delivery
US20030121906A1 (en) 2000-11-29 2003-07-03 Abbott Richard C. Resistive heaters and uses thereof
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6681998B2 (en) * 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US6701921B2 (en) * 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6443152B1 (en) 2001-01-12 2002-09-03 Becton Dickinson And Company Medicament respiratory delivery device
FI20010115A0 (en) 2001-01-18 2001-01-18 Orion Corp A process for preparing nanoparticles
US6680668B2 (en) 2001-01-19 2004-01-20 Vishay Intertechnology, Inc. Fast heat rise resistor using resistive foil
EP1383376A4 (en) 2001-03-19 2006-03-08 Praecis Pharm Inc Pharmaceutical formulations for sustained release
US20030004142A1 (en) * 2001-04-18 2003-01-02 Prior Christopher P. Use of NSAIDs for prevention and treatment of cellular abnormalities of the lung or bronchial pathway
US20030023638A1 (en) * 2001-05-02 2003-01-30 Weight Christopher F. Method and apparatus for processing content
US20030051728A1 (en) * 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
EP1392260A2 (en) * 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Delivery of benzodiazepines through an inhalation route
US20030118512A1 (en) 2001-10-30 2003-06-26 Shen William W. Volatilization of a drug from an inclusion complex
US6805853B2 (en) 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US7585493B2 (en) * 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7645442B2 (en) * 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20030131843A1 (en) 2001-11-21 2003-07-17 Lu Amy T. Open-celled substrates for drug delivery
US20080038363A1 (en) * 2001-05-24 2008-02-14 Zaffaroni Alejandro C Aerosol delivery system and uses thereof
DK1389096T3 (en) 2001-05-24 2009-06-22 Alexza Pharmaceuticals Inc Administration of opiates through an inhalation route
US6759029B2 (en) 2001-05-24 2004-07-06 Alexza Molecular Delivery Corporation Delivery of rizatriptan and zolmitriptan through an inhalation route
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
CA2447519C (en) * 2001-05-24 2008-09-16 Alexza Molecular Delivery Corporation Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
EP1392262A1 (en) * 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
EP1412829B1 (en) * 2001-07-31 2014-03-26 Philip Morris Products S.a.s. Method and apparatus for generating a volatilized liquid
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US6648950B2 (en) 2001-10-15 2003-11-18 Hewlett-Packard Development Company, L.P. Electro-thermal odor-releasing inks and methods for releasing odors from the same
US6779520B2 (en) 2001-10-30 2004-08-24 Iep Pharmaceutical Devices Inc. Breath actuated dry powder inhaler
GB0126150D0 (en) 2001-10-31 2002-01-02 Gw Pharma Ltd A device method and resistive element for vaporising a substance
EP1446102A1 (en) 2001-11-21 2004-08-18 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
US20030106551A1 (en) 2001-12-06 2003-06-12 Sprinkel F. Murphy Resistive heater formed inside a fluid passage of a fluid vaporizing device
US6681769B2 (en) * 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
CN1176075C (en) 2001-12-07 2004-11-17 北京燕山石油化工公司研究院 Pyrrole derivative preparation method
AU2002361742A1 (en) 2001-12-18 2003-06-30 Alexza Molecular Delivery Corporation Parental analgesic formulations comprising fentanyl and a cannabinoid receptor agonist
US6701922B2 (en) * 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
US6772756B2 (en) 2002-02-09 2004-08-10 Advanced Inhalation Revolutions Inc. Method and system for vaporization of a substance
US6961515B2 (en) 2002-02-15 2005-11-01 Dekko Technologies, Inc. PTC heater with flexible printed circuit board
US6728478B2 (en) * 2002-02-21 2004-04-27 Dekko Heating Technologies, Inc. Heated chemical delivery system
WO2003094900A1 (en) * 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Delivery of drug amines through an inhalation route
US20060193788A1 (en) 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
US6909840B2 (en) * 2002-06-06 2005-06-21 S. C. Johnson & Son, Inc. Localized surface volatilization
US7074806B2 (en) * 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CN1700934B (en) * 2002-09-06 2011-08-03 菲利普莫里斯美国公司 Liquid aerosol formulations and aerosol generating devices and methods for generating aerosols
US6772757B2 (en) 2002-10-25 2004-08-10 Chrysalis Technologies Incorporated Concentric controlled temperature profile fluid vaporizing device
AU2003295823B2 (en) 2002-11-26 2009-11-05 Alexza Pharmaceuticals, Inc. Treatment of headache with antipsychotics delivered by inhalation
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
JP2006514934A (en) 2002-11-26 2006-05-18 アレックザ ファーマシューティカルズ， インコーポレイテッド Use of loxapine or amoxapine for the manufacture of drugs for the treatment of pain
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
JP2007516404A (en) 2003-05-21 2007-06-21 アレックザ ファーマシューティカルズ， インコーポレイテッド Optically or electrically ignited built-in heating unit and drug supply unit using the same
CA2534566A1 (en) 2003-08-04 2005-02-24 Alexza Pharmaceuticals, Inc. Substrates for drug delivery device and methods of preparing and use
US20050037506A1 (en) * 2003-08-04 2005-02-17 Alexza Molecular Delivery Corporation Methods of determining film thicknesses for an aerosol delivery article
WO2005061033A1 (en) 2003-12-15 2005-07-07 Alexza Pharmaceuticals, Inc. Treatment of breakthrough pain by drug aerosol inhalation
WO2005059804A2 (en) 2003-12-16 2005-06-30 Alexza Pharmaceuticals, Inc. Methods for monitoring severity of panic attacks and other rapidly evolving medical events in real-time
US7402777B2 (en) 2004-05-20 2008-07-22 Alexza Pharmaceuticals, Inc. Stable initiator compositions and igniters
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP1781360A1 (en) * 2004-08-12 2007-05-09 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
US20060032496A1 (en) 2004-08-12 2006-02-16 Alexza Molecular Delivery Corporation Inhalation actuated percussive ignition system
US20100006092A1 (en) * 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
EP1809240A4 (en) 2004-10-12 2010-06-16 Alexza Pharmaceuticals Inc Cardiac safe, rapid medication delivery
WO2007079118A1 (en) 2005-12-29 2007-07-12 Molex Incorporated Heating element connector assembly with press-fit terminals
US20080299048A1 (en) 2006-12-22 2008-12-04 Alexza Pharmaceuticals, Inc. Mixed drug aerosol compositions
US7513781B2 (en) 2006-12-27 2009-04-07 Molex Incorporated Heating element connector assembly with insert molded strips
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
WO2008134668A2 (en) 2007-04-27 2008-11-06 Alexza Pharmaceuticals, Inc. Heat-labile prodrugs
WO2009089550A1 (en) 2008-01-11 2009-07-16 Alexza Pharmaceuticals, Inc. Metal coordination complexes of volatile drugs
US20100068155A1 (en) 2008-09-16 2010-03-18 Alexza Pharmaceuticals, Inc. Reactant Formulations and Methods for Controlled Heating
US7834295B2 (en) 2008-09-16 2010-11-16 Alexza Pharmaceuticals, Inc. Printable igniters
US20100065052A1 (en) 2008-09-16 2010-03-18 Alexza Pharmaceuticals, Inc. Heating Units
US20100300433A1 (en) 2009-05-28 2010-12-02 Alexza Pharmaceuticals, Inc. Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol
US20100181387A1 (en) 2009-12-01 2010-07-22 Zaffaroni Alejandro C Aerosol delivery system and uses thereof
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
JP6397493B2 (en) 2013-07-11 2018-09-26 アレックザ ファーマシューティカルズ， インコーポレイテッド Nicotine salt with meta-salicylic acid

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