(19) United States
(12) Patent Application Publication (io) Pub. No.: US 2002/0002353 Al
Michal et al. (43) Pub. Date: Jan. 3,2002
(54) THERAPEUTIC, DIAGNOSTIC, OR HYDROPHILIC COATING FOR AN EXTRACORPOREAL MEDICAL DEVICE
(75) Inventors: Eugene T. Michal, San Francisco, CA
(US); Christopher J. Buchko, San
Francisco, CA (US); Stephen J. Bigus,
San Jose, CA (US)
Edward J. Lynch
Heller Ehrman White & McAuliffe
275 Middlefleld Road
Menlo Park, CA 94025-3506 (US)
(73) Assignee: Advanced Cardiovascular Systems, Inc.
(21) Appl. No.: 09/915,413
(22) Filed: Jul. 25, 2001
Related U.S. Application Data
(60) Division of application No. 09/240,914, filed on Jan. 29, 1999, now Pat. No. 6,287,285, which is a continuation-in-part of application No. 09/016,694, filed on Jan. 30, 1998, now Pat. No. 6,221,425.
(51) Int. CI.7 A61M 5/32; B05D 3/00;
A61F 2/06; A61M 25/00
(52) U.S. CI 604/265; 427/2.24; 623/1.25
A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.