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(21) (22) (65)
Appl. No.: Filed:
Richard R. Wilson, Seattle, WA (US); Robert L. Wilcox, Bothell, WA (US); Curtis Genstler, Snohomoish, WA (US); Tim Abrahamson, Seattle, WA (US); Wm. Gerrit Barrere, Lake Forest Park, WA (US); Amy Cohen, Seattle, WA (US); George Keilman, Seattle, WA (US); Leonard R. Oliver, Seattle, WA (US); Natalya Peskin, Redmond, WA (US)
Ekos Corporation, Bothell, WA (US)
Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 705 days.
Dec. 21, 2006
Prior Publication Data
US 2007/0112296 Al May 17, 2007
Related U.S. Application Data
Division of application No. 10/309,388, filed on Dec. 3, 2002, now Pat. No. 7,220,239.
Provisional application No. 60/336,744, filed on Dec. 3, 2001, provisional application No. 60/336,630, filed on Dec. 3, 2001, provisional application No. 60/394, 093, filed on Jul. 3, 2002.
A61B 17/20 (2006.01)
U.S. CI 604/22
Field of Classification Search 604/19 22;
600/437^72; 73/625,626; 601/2,3; 607/22 See application file for complete search history.
(56) References Cited
U.S. PATENT DOCUMENTS
3,433,226 A 3/1969 Boyd
FOREIGN PATENT DOCUMENTS
DE 4005743 8/1991
Hynynen, et al.,"Small Cylindrical Ultrasound Sources for Induction of Hyperthermia Via Body Cavities or Interstitial Implants", Arizona Cancer.
Primary Examiner—Manuel A Mendez
(74) Attorney, Agent, or Firm—Knobbe Martens Olson &
A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.
23 Claims, 25 Drawing Sheets