Metabotropic glutamate receptor antagonists and their use for treating ...

(54) METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AND THEIR USE FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES

(75) Inventors: Bradford C. Van Wagenen; Scott T.

Moe; Daryl L. Smith, all of Salt Lake
City, UT (US); Susan M. Sheehan,
Dexter, MI (US); Irina Shcherbakova;
Richard Travato, both of Salt Lake
City, UT (US); Ruth Walton, Ogden,
UT (US); Robert Barmore, Salt Lake
City, UT (US); Eric G. Delmar, Salt
Lake City, UT (US); Thomas M.
Stormann, Salt Lake City, UT (US)

(73) Assignee: NPS Pharmaceuticals, Inc., Salt Lake City, UT (US)

( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days.

(21) Appl. No.: 09/573,347

(22) Filed: May 19, 2000

Related U.S. Application Data

(63) Continuation-in-part of application No. PCT/US98/24833,

filed on Nov. 20, 1998. (60) Provisional application No. 60/066,758, filed on Nov. 21,

1997, and provisional application No. 60/137,272, filed on

Jun. 2, 1999.

OTHER PUBLICATIONS

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* cited by examiner

Primary Examiner—Charanjit S. Aulakh

(74) Attorney, Agent, or Firm—Foley & Lardner