United States Patent im
Heller et al.
tin 3,811,444 [45] May 21, 1974
[54] BIOERODIBLE OCULAR DEVICE
[75] Inventors: Jorge Heller, Palo Alto; Richard W.
Baker, Mountain View, both of
Calif.
[73] Assignee: Alza Corporation, Palo Alto, Calif.
[22] Filed: Dec. 27, 1972
[21] Appl. No.: 318,891
[52] U.S. CI 128/260, 128/272, 128/156
[51] Int. CI.. A61m 31/00
[58] Field of Search 128/272, 156, 260, 127;
424/19, 22, 365, 33
[56] References Cited
UNITED STATES PATENTS
3,143,472 8/1964 Lappas et al 424/33
3,608,063 9/1971 Banker 424/22
3,629,392 12/1971 Banker 424/22
3,618,604 11/1971 Ness 128/260
2,935,449 5/1960 Bavley 424/312
3,279,996 10/1966 Long, Jr. et al 424/19
3,551,556 12/1970 Kliment et al 424/21
R27,401 6/1972 Wichterle et al 128/127 X
3,674,902 7/1972 Kalopissis 424/365 X
3,630,200 12/1971 Higuchi 128/260
3,710,795 1/1973 Higuchi 128/260
3,737,521 6/1973 Born 424/22
OTHER PUBLICATIONS
David R. Powell and Gilbert S. Banker; "Chemical Modification of Polymeric Film Systems in the Solid State I: Anhydride Acid Conversion", Journal of Pharmaceutical Sciences, Vol. 58, Nov. 1969, pp. 1,335-1,340.
C. R. Willis, Jr. and Gilbert S. Banker; "PolymerDrug Interacted Systems in the Physicochemical Design of Pharmaceutical Dosage Forms I - Drug Salts with PVM/MA and with a PVM/MA Hemi-Ester", Journal of Pharmaceutical Sciences, Vol. 57, Sept. 1968, pp. 1,598-1,603.
Primary Examiner—Aldrich F. Medbery
Attorney, Agent, or Firm—Thomas E. Ciotti; Edward
L. Mandell; Paul L. Sabatine
[57] ABSTRACT
An ocular insert for the continuous controlled administration of a predetermined therapeutically effective dosage of drug to the eye over a prolonged period of time. The insert comprises a drug formulation dispersed through a body of selected hydrophobic polycarboxylic acids which erode in the environment of the eye over a prolonged period of time to dispense the desired amount of drug.
11 Claims, 7 Drawing Figures
