Contact-killing antimicrobial devices

United States Patent [w]

Sawan et al.

US006126931A [ii] Patent Number: [45] Date of Patent:

6,126,931 Oct. 3,2000

[54] CONTACT-KILLING ANTIMICROBIAL DEVICES

[75] Inventors: Samuel P. Sawan, Tyngsboro; Sundar Subramanyam, Stoneham; Alexander Yurkovetskiy, Acton, all ol Mass.

[73] Assignees: Surfacine Development Company,

LLC, Tewksbury, Mass.; BioPolymerix,
Inc., Farnham, United Kingdom

[21] Appl. No.: 09/151,495
[22] Filed: Sep. 11, 1998

Related U.S. Application Data

[62] Division of application No. 08/742,580, Oct. 28, 1996, Pat. No. 5,817,325, which is a continuation-in-part of application No. 08/663,269, filed as application No. PCT/US94/14636, Dec. 19, 1994, Pat. No. 5,869,073, which is a continuationin-part of application No. 08/220,821, Mar. 31, 1994, abandoned, which is a continuation-in-part of application No. 08/170,510, Dec. 20, 1993, Pat. No. 5,490,938.

Int. CI. AO IN 25/10

U.S. CI 424/78.09; 424/78.17;

424/78.34; 424/78.35; 424/405; 424/406; 424/409; 424/411; 424/413; 424/617; 424/618; 574/492; 574/495; 574/634; 574/635; 523/122

Field of Search 424/617, 618,

424/619, 630-643, 646-651, 663, 667-672, 78.09, 78.17, 78.34, 78.35, 404-407, 409, 411-413, 431; 574/695, 634, 635; 523/132;

514/492^194, 499-503

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(List continued on next page.) Primary Examiner—Neil S. Levy

Attorney, Agent, or Firm—Testa, Hurwitz & Thibeault, LLP

Contact killing antimicrobial articles, devices and formulations are described which kill microorganisms on contact. The articles, devices or formulations contain a non-leaching antimicrobial material which is a unique combination ol an organic matrix having biocidal metallic materials nonleachably associated with the matrix. The antimicrobial material may used to form an antimicrobial coating or layer on a surface ol the article or device, or may be dispersed in a vehicle or carrier to form a topical antiseptic or disinlectant, or solid shape having contact killing antimicrobial properties. When a microorganism contacts the article, device, or formulation, the biocidal metallic material is translerred to the microorganism in amounts sufficient to kill it.

12 Claims, 3 Drawing Sheets

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