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US006752961B2

(12) United States Patent ao) Patent No.: us 6,752,961 B2

Kopf-Sill et al. (45) Date of Patent: Jun. 22,2004

(54) MODIFIED SIPHONS FOR IMPROVING METERING PRECISION

(75) Inventors: Anne R. Kopf-Sill, Portola Valley, CA (US); Carol T. Schembri, San Mateo, CA (US)

(73) Assignee: Abaxis, Inc., Union City, CA (US)

( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) bydays.days.

(21) Appl. No.: 09/834,300

(22) Filed: Apr. 12, 2001

(65) Prior Publication Data

US 2003/0207457 Al Nov. 6, 2003

Related U.S. Application Data

(63) Continuation of application No. 08/562,327, filed on Nov. 22, 1995, now Pat. No. 6,235,531, which is a continuation of application No. 08/254,406, filed on Jun. 6, 1994, now abandoned, which is a continuation-in-part of application No. 08/115,162, filed on Sep. 1, 1993, now Pat. No. 5,591, 643.

(51) Int. C I. G01N 9/30

(52) U.S. CI 422/72; 422/100; 422/102;

436/45; 436/180

(58) Field of Search 422/72, 100, 102;

436/45, 180

(56) References Cited

U.S. PATENT DOCUMENTS

4,244,916 A 1/1981 Guigan 422/72

4,314,968 A 2/1982 Guigan 422/64

4,623,519 A 11/1986 Comut et al 422/72

4,689,203 A 8/1987 Kaartinen et al 422/72

4,743,558 A 5/1988 Guigan 436/45

4,761,268 A 8/1988 Andersen et al 422/72

4.876.203 A 10/1989 Guigan 436/45

4.894.204 A 1/1990 Comut 422/72

4,902,479 A 2/1990 Brikus 422/72

4,963,498 A 10/1990 Hillman et al 436/69

4,999,304 A 3/1991 Robertson 436/45

5,061,381 A 10/1991 Burd 210/789

5,071,625 A 12/1991 Kelln et al 422/72

5,077,013 A 12/1991 Guigan 422/64

5,104,813 A 4/1992 Besemer et al 436/179

5,122,284 A 6/1992 Braynin et al 210/782

5,160,702 A 11/1992 Kopf-Sill et al 422/72

5,173,193 A 12/1992 Schembri 210/782

5,173,262 A 12/1992 Burtis et al 422/72

5,186,844 A 2/1993 Burd et al 210/782

5,256,376 A 10/1993 Callan et al 422/102

5,457,053 A * 10/1995 Burd et al 436/45

5,693,233 A * 12/1997 Schembri 210/787

OTHER PUBLICATIONS

Tech Update, "Blood Rotor Test Magic," Popular Mechanics, Feb. 1993.

Schembri, C. Abstract, "Centrifligation and Capillary Inte-
grated into a Multiple Analyte Whole Blood Analyzer,"
Abaxis, Inc., Feb. 1993.
Marketing Brochure, Abaxis, Inc., Aug. 1993.

* cited by examiner

Primary Examiner—-Jan M. Ludlow

(74) Attorney, Agent, or Firm—Gray, Cary, Ware & Freidenrich LLP

(57) ABSTRACT

The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors comprise siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.

6 Claims, 6 Drawing Sheets

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