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US006416779B1
(12) United States Patent ao) Patent No.: us 6,416,779 Bi
D'Augustine et al. (45) Date of Patent: *Jul. 9,2002
(54) DEVICE AND METHOD FOR
INTRAVAGINAL OR TRANSVAGINAL
TREATMENT OF FUNGAL, BACTERIAL,
VIRAL OR PARASITIC INFECTIONS
(75) Inventors: Merida A. D'Augustine; James H.
Liu; Donald C. Harrison, all of
Cincinnati, OH (US)
(73) Assignee: UMD, Inc., Cincinnati, OH (US)
( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days.
This patent is subject to a terminal disclaimer.
(21) Appl. No.: 09/613,441
(22) Filed: Jul. 11, 2000
Related U.S. Application Data
(63) Continuation-in-part of application No. 09/249,963, filed on Feb. 12, 1999, now Pat. No. 6,086,909, which is a continuation-in-part of application No. 09/079,897, filed on May 15, 1998, now Pat. No. 6,197,327.
(60) Provisional application No. 60/049,325, filed on Jun. 11, 1997.
(51) Int. CI.7 A61F 6/08; A61F 6/06;
A61F 6/14
(52) U.S. CI 424/430; 424/431; 424/432;
424/434; 424/443; 424/433
(58) Field of Search 424/430, 431,
424/432, 434, 443, 433
(56) References Cited
U.S. PATENT DOCUMENTS
3,852,155 A 12/1974 Moore 195/1.8
4,016,270 A 4/1977 Pharriss et al 424/242
4,073,743 A 2/1978 Midler, Jr. et al 252/309
4,250,166 A 2/1981 Mackawa et al 424/81
4,318,405 A 3/1982 Sneider 128/263
4,405,323 A 9/1983 Auerbach 604/285
4,540,581 A 9/1985 Nair et al 514/415
4,560,549 A 12/1985 Ritchey 424/18
4,615,697 A 10/1986 Robinson 604/890
4,789,667 A 12/1988 Makino et al 514/161
4,863,725 A 9/1989 Deckner et al 424/81
4,983,392 A 1/1991 Robinson 424/427
5,026,543 A 6/1991 Rijke 424/81
5,084,277 A 1/1992 Greco et al 424/433
5,185,146 A 2/1993 Altenburger 424/89
5,192,802 A 3/1993 Rencher 514/535
5,201,326 A 4/1993 Kubicki et al 128/832
5,246,697 A 9/1993 Conte et al 424/78.03
5,273,521 A 12/1993 Peller et al 604/13
5,275,820 A 1/1994 Change 424/426
5,314,915 A 5/1994 Rencher 514/535
5,330,761 A 7/1994 Baichwal 424/469
5,362,498 A 11/1994 Aiache 424/435
5,393,528 A 2/1995 Staab 424/436
5,527,534 A 6/1996 Myhling 424/430
5,742,525 A * 4/1998 Larsen 424/616
5,788,980 A 8/1998 Nabahi 424/430
5,985,319 A * 11/1999 Embil et al 424/450
6,086,909 A * 7/2000 Harrison et al 424/430
FOREIGN PATENT DOCUMENTS
WO WO 87/02576 5/1987 A61F/5/46
WO WO 89/03207 4/1989 A61K/9/50
* cited by examiner
Primary Examiner—Thurman K. Page Assistant Examiner—Rachel M. Bennett (74) Attorney, Agent, or Firm—Hana Verny
(57) ABSTRACT
Devices, methods, and compositions for treating vaginal fungal, bacterial, viral and parasitic infections by intravaginal or transvaginal administration of therapeutic and/or palliative antifungal, antibacterial, antiviral or parasiticidal drugs to the vagina or to the uterus.
18 Claims, 6 Drawing Sheets
