IIIH
US007045310B2
(12) United States Patent ao) Patent No.: Us 7,045,310 B2
Buck, Jr. et al. (45) Date of Patent: May 16,2006
(54) REDOX REVERSIBLE BIPYRIDYL-OSMIUM
COMPLEX CONJUGATES
(75) Inventors: Harvey B. Buck, Jr., Indianapolis, IN
(US); Zhi David Deng, Carmel, IN
(US); Eric R. Diebold, Noblesville, IN
(US)
(73) Assignee: Roche Diagnostics Operations, Inc.,
Indianapolis, IN (US)
( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 713 days.
(21) Appl. No.: 09/999,110
(22) Filed: Nov. 1, 2001
(65) Prior Publication Data
US 2002/0090632 Al Jul. 11, 2002
Related U.S. Application Data
(62) Division of application No. 09/322,791, filed on May 28, 1999, now Pat. No. 6,352,824.
(60) Provisional application No. 60/087,576, filed on Jun. 1, 1998.
(51) Int. CI.
G01N 33/53 (2006.01)
G01N 33/72 (2006.01)
(52) U.S. CI 435/7.93; 435/4; 435/5
435/6; 435/7.1; 435/7.93; 436/15; 436/66 436/67; 436/84; 436/172; 436/805; 436/806 436/501; 436/517; 436/518; 436/536; 436/544 436/545; 530/303; 530/304; 530/385
(58) Field of Classification Search 435/4,
435/6, 7.1, 7.2, 7.92, 7.93, 287.2, 968; 436/501,
436/536, 56, 66, 67, 538, 546, 164, 172;
530/303, 304, 385 See application file for complete search history.
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