Topical aminolevulinic acid-photodynamic therapy for the treatment of acne ...

(54) TOPICAL AMINOLEVULINIC

ACID-PHOTODYNAMIC THERAPY FOR
THE TREATMENT OF ACNE VULGARIS

(75) Inventor: Richard Rox Anderson, Lexington,
MA (US)

(73) Assignee: General Hospital Corporation,

Boston, MA (US)

( * ) Notice: Subject to any disclaimer, the term ol this patent is extended or adjusted under 35 U.S.C. 154(b) by 15 days.

(21) Appl. No.: 09/929,384

(22) Filed: Aug. 14, 2001

(65) Prior Publication Data

US 2002/0099094 Al Jul. 25, 2002

Related U.S. Application Data

(60) Provisional application No. 60/225,691, filed on Aug. 16, 2000.

(51) Int. CI.7 A61K 31/195; A61K 7/42

(52) U.S. CI 514/563; 514/561; 514/814;

424/59

(58) Field of Search 514/561, 814,

514/563, 410; 424/59, 60

(56) References Cited

U.S. PATENT DOCUMENTS

OTHER PUBLICATIONS

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Hongcharu et al., The Society for Investigative Dermatology, Inc., Topical ALA-Photodynamic Therapy for the Treatment of Acne Vulgaris, pp. 1-9 (2000).

Peng et al., Journal of Photochemistry and Photobiology B. Biology 34, Build up of esterfield aminolevulinic-acidderivative-induced porphyrin fluorescence in normal mouse skin, pp. 95-96 (1996).

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Sigurdsson et al "Phototherapy of Acne Vulgaris with Visible Light" Dermatology, vol. 194, pp. 256-260 (1997).

(Continued) Primary Examiner—-Vickie Kim

(74) Attorney, Agent, or Firm—Nutter, McClennen & Fish LLP

Light treatments of sebaceous gland disorders with 5-aminolevulinic acid and photodynamic therapy are disclosed. A preferred treatment includes topical application of 5-aminolevulinic acid to the skin followed by light exposures with repeated treatment at various intervals. At low doses of ALA and photodynamic therapy (PDT) in single or multiple treatments, improvement in the sebaceous gland disorder, e.g., acne, provides the discovery that diminishment in sebum secretion and the eradication of bacteria occurs. At high doses of ALA and a single high energy PDT treatment, permanent changes to the sebaceous gland and sebum secretion have been discovered.

13 Claims, 15 Drawing Sheets

OTHER PUBLICATIONS

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* cited by examiner