Preparation comprising cavitate- or clathrate-forming host/guest complexes ...

[54] PREPARATION COMPRISING CAVITATEOR CLATHRATE-FORMING HOST/GUEST COMPLEXES AS CONTRAST AGENT

[75] Inventors: Celal Albayrak; Georg Rossling;

Johannes Tack, all of Berlin, Germany

[73] Assignee: Schering Aktiengesellschaft. Berlin,
Germany

[21] Appl. No.: 322,966
[22] Filed: Oct 13,1994

Related U.S. Application Data

[63] Continuation of Ser. No. 973,315, Nov. 9,1992, abandoned, which is a continuation of Ser. No. 656,099, Feb. 25,1991, abandoned.

[30] Foreign Application Priority Data

Aug. 23, 1988 [DE] Germany 38 28 905.9

[51] Lit CL6 A61K 49/00; G01N 31/00;

G01N 33/48

[52] U.S. CI 424/9.52; 424/9.1; 424/9.5

[58] Field of Search 424/9, 9.1. 9.5,

424/9.51, 9.52, 400, 450; 128/662.02

[56] References Cited

U.S. PATENT DOCUMENTS

4,276,885 7/1981 Tickneretal 128/660

4,657,756 4/1987 Rasoretal 424/9

4,681,119 7/1987 Rasoretal 128/662.02

4,684,479 8/1987 D'Amgo 252/307

4,718,433 1/1988 Feinstein 128/662.02

4,844,882 7/1989 Widderetal 424/9

4,925,652 5/1990 Gries etal 424/9

FOREIGN PATENT DOCUMENTS

36 37 926 11/1987 Germany .

OTHER PUBLICATIONS

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Primary Examiner—John Kight

Assistant Examiner—Dameron Jones

Attorney, Agent, or Firm—Millen, White, Zelano &

Branigan, PC.

[57] ABSTRACT

A method of using cavitate- or clathrate-forming host/guest complexes for the preparation of contrast media in ultrasonic examination is provided. The host/guest complexes have a host which dissolves in a liquid carrier, releasing the guest (inert gas). With such contrast media, it is possible to diagnose blood and its flow conditions in the heart, and other organs, such as the myocardium, liver, spleen, and kidneys. Other internal systems such as the urinary ducts, the gastrointestinal tract, joints, and eyes can also be imaged.

15 Claims, 4 Drawing Sheets