Drug delivery device

US007943162B2

<12) United States Patent (10) Patent N0.: US 7,943,162 B2 Missel et al. (45) Date of Patent: *May 17, 2011 (54) DRUG DELIVERY DEVICE (56) References Cited (75) Inventors: Paul J. Missel, Arlington, TX (US); U-S- PATENT DOCUMENTS Yoseph Yaacobi, Fort Worth, TX (US) 3,416,530 A 12/1963 Ness 3,828,777 A 8/1974 Ness (73) Assignee: Alcon,Inc., Hunenberg (CH) 4,014,335 A 3/1977 Arnold 4,256,108 A 3/1981 Theeuwes ( * ) Notice" Subject to any disclaimer the term of this Q Eefitno ettalt ' ’ , , O €S€ € 3. . patent is extended or adjusted under 35 4,624,343 A 11/1936 Lee U.S.C. l54(b) by 1137 days. 2 E/°I1_g , , I'W1Il This patent is subject to a tenninal dis- 4,997,652 A 3/1991 Wong C1aimer_ 5,147,647 A 9/1992 Darougar 5,164,188 A 11/1992 Wong 5 178 635 A 1/1993 Gwon et al. 21 A l. No.: 11/567 892 ’ ’ . ( ) pp ’ (Continued) (22) F1100: D°°' 7’ 2006 FOREIGN PATENT DOCUMENTS (65) Prior Publication Data DE 40 22 553 $1 _ 1/(11992 US 2007/0092570 A1 Apr. 26, 2007 1 Ommue 1 OTHER PUBLICATIONS Related U.S. Application Data _ _ _ _ _ R. A. Pontes de Carvalho, et al.; “Delivery from Episcleral (63) COm1nuat1On'1n'Pan of apphcanon NO~ 10/9_57=9_10= Exoplants”; Investigative Ophthamology &Visua1 Science; vol. 47, filfid O11 OCT. 4, 2004, HOW 2lb21I1dOI1€d, W111C11 1S 21 NO_ 10; Oet_ 2006; pp 45324539; gpgst continuation of application No. 10/186,960, filed on _ Jul. 1, 2002, now Pat. NO. 6,808,719, which is a (comlnued) continuation of application No. 09/660,000, filed on _ _ _ Sep. 12, 2000, now Pat. NO. 6,413,540. 1([;’A’t;”‘;1’ZyZ Exam?’ 7 Huge” N %1,1e]1)1‘1‘ _d L orney, gen , or zrm — . avi ee (60) Provisional application No. 60/160,673, filed on Oct. 21, 1999. (57) ABSTRACT 51 I t Cl Drug delivery devices, and methods of delivering phannaceu( ) n ‘ ‘ tically active agents to atarget tissue withinabody using such A61F 2/00 (200001) devices, are disclosed. One drug delivery device includes a A61F13/00 (200601) body having an intemal surface for disposing on a target /161K 9/00 (200001) tissue andawell having anopening to the internal surface.An (52) U.S. Cl. ...... .. 424/427; 424/422; 424/423; 424/426; ihher eere eemprisihg a drug eehtaihihg portion and ah 424/428$ 424/429 expandable material is disposed in the well. (58) Field of Classification Search ...................... .. None See application file for complete search history. 3 Claims, 6 Drawing Sheets 1-.’ 8 KT 1 O I 20

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5,300,114 5,322,691 5,378,475 5,403,901 5,443,505 5,466,233 5,466,466 5,476,511 5,516,522 5,632,984 5,679,666 5,710,165 5,725,493 5,743,274 5,766,242 5,766,619 5,770,592 5,773,019 5,797,898 5,824,072 5,824,073 5,830,173 5,836,935 5,860,994 5,883,108 5,902,598 5,904,144 5,916,584 6,001,088 6,001,386 6,074,661 6,110,485 6,120,460 6,126,687 6,146,366 6,217,895 6,375,972 6,378,526 6,397,849 6,413,245 6,413,540 6,416,777 6,582,422 6,669,950 6,713,081 6,719,750 6,808,719 7,195,774 7,276,050 2002/0188282 2003/0175324 2004/0071761

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