Bioresorbable compositions of carboxypolysaccharide polyether ...

United States Patent [w]

Schwartz et al.

US006034140A [ii] Patent Number: [45] Date of Patent:

6,034,140 Mar. 7,2000

[54] BIORESORBABLE COMPOSITIONS OF

CARBOXYPOLYSACCHARIDE POLYETHER
INTERMACROMOLECULAR COMPLEXES
AND METHODS FOR THEIR USE IN
REDUCING SURGICAL ADHESIONS

[75] Inventors: Herbert E. Schwartz; John M.

Blackmore, both of Redwood City,
Calif.

[73] Assignee: FzioMed, Inc., San Luis Obispo, Calif.

[21] Appl. No.: 09/023,097 [22] Filed: Feb. 13, 1998

Related U.S. Application Data

[62] Division of application No. 08/877,649, Jun. 17, 1997, Pat. No. 5,906,997.

[51] Int. CI.7 A61K 31/715; A61K 47/00

[52] U.S. CI 514/781; 536/54; 536/56;

536/57; 536/58; 536/59; 514/944; 600/556

[58] Field of Search 514/54, 56, 57,

514/58, 59, 944, 781; 600/556

[56] References Cited

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(List continued on next page.) Primary Examiner—Gary L. Kunz

Attorney, Agent, or Firm—Fliesler Dubb Meyer & Lovejoy LLP

The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides and polyethers, and to the resulting compositions. The polymers are associated with each other, and are then either dried or are used as fluids. Bioresorbable, bioadhesive, anti-adhesion compositions are useful in surgery to prevent the formation of post-surgical adhesions. The compositions are designed to breakdown in-vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. The antiadhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes can be varied as needed by carefully adjusting the pH of the polymer casting solutions, polysaccharide composition, the polyether composition, or by conditioning the membranes prior to surgical use. Bi- or multi-layered membranes can be made and used to provide further control over the physical and biological properties of antiadhesion membranes. Antiadhesion compositions may also be used to deliver drugs to the surgical site and release them locally.

24 Claims, 7 Drawing Sheets

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