[ii] Patent Number: 5,016,652  Date of Patent: May 21, 1991
 METHOD AND APPARATUS FOR AIDING IN THE REDUCTION OF INCIDENCE OF TOBACCO SMOKING
 Inventors: Jed E. Rose, Venice; Murray E.
Jarvik, Santa Monica, both of Calif.
 Assignee: The Regents of the University of California, Berkely, Calif.
 Appl. No.: 157,627
 Filed: Feb. 19,1988
Related U.S. Application Data
 Continuation of Ser. No. 727,525, Apr. 25, 1985.
 Int. CI.' A24F 47/00
 U.S. CI 131/270; 31/273;
424/44; 424/447; 424/448; 424/449; 604/305;
 Field of Search 131/270, 273; 424/4,
424/44, 28, 447, 448, 449; 604/896, 897, 46, 289, 304, 305, 890.1
A dermally applicable patch adapted for application to the skin of the user-to enable a transdermal administration to the bloodstream of a user. The patch comprises an outer layer which is impermeable to the passage of nicotine and an inner layer which may operate as a rate controlling membrane to allow the passage of nicotine into the bloodstream of a user. An outer layer and an inner layer form a nicotine receiving area for receiving the nicotine to thereby allow the same to pass through the inner layer. In a preferred embodiment, the patch is highly effective in reducing the incidence of tobacco smoking by allowing transdermal nicotine migration into the bloodstream of a user at a rate sufficient to correspond to the nicotine level in the blood achieved by smoking.
24 Claims, 3 Drawing Sheets