OTHER PUBLICATIONS
Altruis Biomedical Network, Growth Factor.net, 2002,1-3.*
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She et al., "Placental alkaline phosphatase, insulin, and adenine nucleotides or adenosine syndergistically promote long-term survival ol serum-starved mouse embryo and human letus fibroblasts," Cellular Signalling, 2000,12:659665.
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* cited by examiner
Primary Examiner—Michael Meller
(74) Attorney, Agent, or Firm—Fish & Richardson PC, PA.
It has been found that placental alkaline phosphatase interacts synergistically with growth lactors and corresponding serum lactors to stimulate the prolileration ol adult fibroblast cells. Furthermore, this stimulation ol fibroblast prolileration does not result in a corresponding stimulation ol collagen synthesis. Thus, wound healing compositions can be formulated that improve wound healing without increasing scar formation. Compositions for wound healing can include placental alkaline phosphatase and a gel-forming material. In some embodiments, compositions include placental alkaline phosphatase and serum/growth lactors. In addition to wound healing applications, compositions with placental alkaline phosphatase can also be used in cell culturing ol adult fibroblast cells.
12 Claims, 13 Drawing Sheets
