Methods for stimulating proliferation of cells in the epidermis and dermis of mammalian skin are disclosed. The methods comprise the step of administering to an area of the skin a composition comprising a therapeutically effective amount of human placental alkaline phosphatase, or an active derivative....http://www.google.com.au/patents/US7374754?utm_source=gb-gplus-sharePatent US7374754 - Use of placental alkaline phosphatase to promote skin cell proliferation