A method for detecting the presence of a high-molecular-weight analyte, which uses a variation on complementation assays, comprising (1) providing an enzyme donor (ED)complex comprising ED coupled to an analyte-specific binding molecule, wherein the ED complex retains measurable complementation activity...http://www.google.com.au/patents/US5244785?utm_source=gb-gplus-sharePatent US5244785 - Determination of high molecular weight analytes using a .beta.-galactosidase complementation assay
