The present invention is directed to a substrate having a plurality of microfeatures that provide a high surface area and are open to provide ready access to fluids and components therein. Methods of making the high surface area substrates are described and include generating microfeatures and/or microstructures...http://www.google.com.au/patents/US7195872?utm_source=gb-gplus-sharePatent US7195872 - High surface area substrates for microarrays and methods to make same