The invention discloses methods and compositions for enhanced skin concentration of iontophoretic delivered active agents. The compositions are pharmaceutically acceptable compositions for iontophoretic delivery which comprise a skin concentration enhancing amount of a vasoconstrictor and active agent....http://www.google.com.au/patents/US5334138?utm_source=gb-gplus-sharePatent US5334138 - Method and composition for increased skin concentration of active agents by iontophoresis