The invention provides nonhuman transgenic animals with a disrupted FHIT gene. The invention further provides transgenic mice in which one or both Fhit alleles have been inactivated. Preferably, the Fhit-deficient mice develop multiple tumors of both visceral and sebaceous origin, similar to those of...http://www.google.com.au/patents/US6924414?utm_source=gb-gplus-sharePatent US6924414 - Muir-torre-like syndrome in Fhit deficient mice