The compositions and methods of the present invention are based, in part, on our discovery that an effector function mediated by an Fc-containing polypeptide can be altered by modifying one or more amino acid residues within the polypeptide (by, for example, electrostatic optimization). The polypeptides...http://www.google.com.au/patents/US20060275283?utm_source=gb-gplus-sharePatent US20060275283 - Fcgamma receptor-binding polypeptide variants and methods related thereto