The invention provides a LM609 grafted antibody comprising one or more CDRs having at least one amino acid substitution, where the LM609 grafted antibody has v3 binding activity. Nucleic acids encoding LM609 grafted heavy and light chains are additionally provided. Functional fragments of such encoding...http://www.google.com.au/patents/US6596850?utm_source=gb-gplus-sharePatent US6596850 - Anti-