Methods for engineering a target activated biosensor are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules which do not naturally bind to DNA. Binding...http://www.google.com.au/patents/US20030087239?utm_source=gb-gplus-sharePatent US20030087239 - Target activated nucleic acid biosensor and methods of using same