The invention provides an apparatus for interrogating an optical biosensor. The apparatus includes (a) locating means for positioning one or more optical biosensors; (b) calibration means for generating a reference measurement; (c) one or more biosensors for generating one or more sample measurements,...http://www.google.com.au/patents/US7413893?utm_source=gb-gplus-sharePatent US7413893 - Methods, apparatus and compositions for improved measurements with optical biosensors