A technique is disclosed that is useful for determining the presence of specific hybridization expression within an output pattern generated from a digitized image of a biological sample applied to an arrayed platform. The output pattern includes signals associated with noise, and signals associated...http://www.google.com.au/patents/US6780589?utm_source=gb-gplus-sharePatent US6780589 - Method and system using active signal processing for repeatable signal amplification in dynamic noise backgrounds