This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi moieties released from NTPs as a polymerase extension product is created. ...http://www.google.com.au/patents/US20030194740?utm_source=gb-gplus-sharePatent US20030194740 - System and method for nucleic acid sequencing by polymerase synthesis