The present invention provides for a method of using BOC/CDO hedgehog antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders,...http://www.google.com.au/patents/US7625759?utm_source=gb-gplus-sharePatent US7625759 - Method for using BOC/CDO to modulate hedgehog signaling