Antibodies against AILIM (also called ICOS and 8F4) were found to significantly suppress the onset of inflammatory bowel diseases (especially Crohn's disease and colitis (ulcerative colitis and such)), and exhibit a significant therapeutic effect against inflammatory bowel diseases....http://www.google.com.au/patents/US7465444?utm_source=gb-gplus-sharePatent US7465444 - Methods of suppressing or treating an inflammatory bowel disease by administering an antibody or portion thereof that binds to AILIM