The invention relates to transgenic non-human animals capable of producing high affinity human sequence antibodies. The invention is also directed to human sequence antibodies specific for human antigens, such as, human CD4. The invention also is directed to methods for producing human sequence anti...http://www.google.com.au/patents/US7084260?utm_source=gb-gplus-sharePatent US7084260 - High affinity human antibodies and human antibodies against human antigens