WO2016113291A1

WO2016113291A1 - Packaging device for drugs

Info

Publication number: WO2016113291A1
Application number: PCT/EP2016/050544
Authority: WO
Inventors: Dietmar Gross
Original assignee: Carefusion Germany 326 Gmbh
Priority date: 2015-01-16
Filing date: 2016-01-13
Publication date: 2016-07-21
Also published as: DK3045397T3; CA2985677C; JP6856531B2; MX364420B; MX2017009240A; KR102423996B1; EP3045397B1; AU2016208113A1; KR20170102866A; PT3045397T; AU2016208113B2; BR112017011839B1; CN107428424B; EP3045397A1; JP2018502019A; BR112017011839A2; CA2985677A1; ES2618062T3; CN107428424A

Abstract

The invention relates to a packaging device for drugs. The problem addressed by the invention is the fact that drugs cannot be optimally arranged in the packaging in the case of known packaging devices. This problem is solved in that the packaging device according to the invention comprises a packaging-material feed (10) and a folding and guiding device (20), wherein the folding and guiding device (20) folds a packaging-material web (2) in the longitudinal direction in that the edges of the packaging-material web are guided along packing-material-web folding regions (22a, 22b) and a folding segment (23) defines a folding region (3) in the packaging-material web (2), and wherein the folding and guiding device (20) has an impact region (24) for drugs to be packaged, a first joining device (40), and a second joining device (50), wherein the folding and guiding device (20) has a drug-feeding segment (25), which is spaced apart from the folding segment (23) and by means of which drugs can be guided into the folded packaging-material web (2) at a vertical distance from the folding region (3).

Description

Packaging device for pharmaceuticals

The present invention relates to a

Pharmaceutical packaging device, and in particular a packaging device for use in a blister machine.

Corresponding blister machines are from the state of

Technique known. For example, WO 2013/034504 A1 describes a pharmacy and hospital or, with appropriate dimensioning, also usable in blister centers

Blister machines, the drug individualized patient according to the medically prescribed intake times. The packaging device of the blister machine packs the

Drug compositions (which may contain only one drug or a plurality of individual drugs) in bags formed from an endless web of packaging material, so-called blister bags, these bags being referred to as

"Blister" the packaging device to further

Use leave (as Blisterschlauch be the

strung together, not yet separated filled

Blister bag called). A blister bag corresponds

regularly a time of administration of a patient, i. contains all medicines that a patient, e.g. in the morning.

The blister machine according to the aforementioned WO document comprises a plurality of storage and dispensing devices for

Medicines containing a variety of circumferential

Guidance devices cooperate, which also supply the drugs circulating collection devices through which the drug compositions are supplied to a packaging device. The blister machine may be due to the

special construction a variety of

Provide drug compositions in a short time, which makes special demands on the packaging device.

In known packaging devices are the

provided drug compositions of the device itself supplied via appropriate transport facilities and packed in blisters in the packaging device (this process is also referred to as blistering). At a given position, the drug composition is transferred to the packaging device. this happens

for example, by temporarily opening the transport device, whereupon the pharmaceutical composition falls onto a baffle plate provided for this purpose. at

Packaging devices according to the prior art, the baffle plate serves as a shaping / folding aid for a guided past this packaging material web (from which the packaging device forms the individual blister bag). The packaging material web is usually folded along the longitudinal axis in such a way that the fold region is arranged "below." From the baffle plate, the individual drugs of the drug composition slip into the

Fold region, where a stop is regularly formed by the vertical welding of the previous bag.

Due to the orientation of the baffle plate and the folded packaging material web, the direction of movement of the

Packaging material web and the construction of the baffle plate, that the drugs to be packaged regularly in succession in the pre-folded packaging material web. In

Dependent on the number of drugs can thus produce relatively long bags, which leads to a waste of material and increase the duration of packaging.

Depending on the shape of the packaged

Medicinal causes the geometry of the impact plate, that drug partially the prefolded section of the

Packaging material web are fed so unfavorable

(For example, tablets in the form of a flat circular cylinder on a face) that it causes problems in the

Closing the prefolded filled section of the

Packaging material web and their further transport through the packaging device can come.

It is an object of the present invention to provide a

To provide a drug delivery device in which the delivery of drugs into the prefolded Packaging material web is improved so that shorter drug bag can be produced.

The object is achieved by a

Packaging device for medicaments according to claim 1. The packaging device according to the invention comprises a

A packaging material supply for supplying a flexible, elongated packaging material web from a supply roll and a folding and guiding device arranged downstream of the packaging material supply (the term "downstream" refers to the direction of movement of the packaging material web, starting from the supply roll through which

Packing device).

The folding and guiding device comprises a

Packing material web pickup area and two

Packaging material web folding areas, which converge in a folding section, which is arranged opposite to the receiving area of the folding and guiding device. The folding and

Guide device of the packaging device according to the invention folds the packaging material web in the longitudinal direction by the edges of the packaging material web to the

Packaging material fold areas are guided along and the folding portion a folding area in the

Packaging material web sets, creating a folded

Packaging material web with rudimentary U-shaped cross section is formed.

This pre-folded U-shaped area of

Packaging material web, the movement of the

Continuously "formed" packaging material web, the drugs are supplied during the packaging process;

hereinafter this area will be referred to as "packaging area"

designated .

The folding and guiding device comprises a

Impact area for drugs to be packaged, with the

Drugs are guided from this impact area in the area of the folded packaging material web (packaging area). The packaging device according to the invention comprises a first joining device arranged downstream of the folding and guiding device, with which the folded one

Packaging material web vertical to the longitudinal direction

is joined together, wherein pro to be produced

Pharmaceutical bag or blister bag usually two vertical joining areas are produced. Since the blister bag in the device after packaging or manufacturing

Usually not be separated, a joining area is used regularly as the "end" of a previous blister bag and "beginning" of a new blister bag. Depending on the exact configuration of the first joining device, however, two separate vertical joint regions can also be produced per blister bag.

The packaging apparatus further includes a downstream of

Falt- and guide device arranged second

Joining device with which the folded

Packaging material web is joined parallel to the longitudinal direction and opposite or spaced from the folding area.

The order in which the first and second joining devices are arranged with respect to the direction of movement of the packaging material web within the packaging device is not essential to the present invention and depends on

constructive details of the packaging device. It is usual, however, the first joining device of the folding and

Nachführung management device.

The folding and guiding device according to the invention comprises a medicament delivery section spaced from the folding section, over which the medicament to be packaged is vertically spaced from the fold region into the folded (and vertically assembled downstream of the delivery region).

Packaging material web (the packaging area) are passed.

In prior art packaging devices, flat baffles are used by means of which the medicaments to be packaged are supplied to the packaging area in vertical proximity to the fold area, which is regular causes the drugs, due to the movement of the packaging material web during packaging, are arranged substantially one behind the other, so that the volume of drug bag produced in the course of Verblistern this only

is insufficiently exploited and this, based on the

Longitudinal direction of the packaging material web, relatively "long" fails.

Due to the inventive design of the folding and guiding device, the medicaments are guided vertically spaced from the folding area in the packaging area, so that the drugs initially stopped by the vertical

Joining area of the preceding drug bag, fall on the folding area and subsequent medicines may be arranged over already delivered drugs. The

medicines to be supplied are no longer hindered

each other, so that at constant speed

(compared with known packaging devices) the same number of drugs more quickly and into a "shorter"

Pharmaceutical bag can be packed, since the drugs are arranged in this not only one behind the other, but also one above the other. When using a folding and guiding device according to the invention, the supply of the individual

Drugs of the drug composition thus improved so that shorter drug bag can be produced, which u.a. leads to a saving of material with regard to the packaging material. At the same time, however, a faster blistering is also possible, since the device can be operated faster due to the lower hinderance of the individual drugs during the delivery.

When using known baffles it is in

unfavorable cases possible that circular cylindrical

Medicines on their face the folded

Packaging material web area are supplied. Provided

Medicaments are to be packed with a relatively large radius, so it may happen that these, based on their radius, vertically to the direction of movement of

Packaging material web to be supplied and packaged, depending on the size of the drug and the

Filling a folded to be closed

Packaging material range to problems in the

can lead to subsequent joining areas. If, for example, the folded packaging material web is too bulged, it may be too "flat" to be in the second joining device

be joined together parallel to the longitudinal device, since the packaging material simply does not reach the actual joining region of the joining device.

In a preferred embodiment of the invention

Packaging device, it is therefore intended that the impact area providing surface of the folding and

Guide device is concave. This leads, on the one hand, to the impact area having a steeper angle of inclination (compared to a surface without a concave one)

Embodiment), the arranged in the top of the triangular folding and guiding device drug delivery section, however, is flatter, so that the surface of the folding and guiding device a kind of "ski jump"

represents over which the drug is particularly effective and directed (approximately parallel to the joining area) in the

Prefolded area of the packaging material web are performed. There forms a vertical joining area of a

an initial attack on the drug

Drug, from which these fall to the fold area, so that an arrangement is more likely one above the other.

The impact of the drugs in the impact area of the folding and guiding device regularly burst smallest

Drug particles from and contaminate the surface of the folding and guiding device. Subsequent drugs may also entangle the contaminant particles, thus increasing the contamination of the drugs over time

Pharmaceutical bags can take place. It is therefore necessary to replace the folding and guiding device regularly, which is time consuming and an undesirable interruption of

Blinding necessary. In a preferred embodiment of the packaging device according to the invention, it is therefore provided that the folding and guiding device comprises a releasable drug delivery member and a folding member, wherein the feed section is part of the releasable drug delivery member and the folding portion is part of the folding member. Once a certain

Pollution level is reached, due to the

inventive design of the folding and

Only with the medicines in

Contact coming detachable drug delivery component to be replaced, the folding component, which ensures the guidance and folding of the packaging material web can in the

Packaging device remain. The replacement can be done much faster, since it is no longer

it is necessary to insert the complete folding and guiding device in the guide path of the packaging material web.

As already described above, a significant advantage of the packaging device according to the invention, the pharmaceuticals are also arranged one above the other in the packaging area. An optimal arrangement of the drugs in the folded

Area of the packaging material web is dependent on the distance of the feed section to the folding area of the

Packaging material web, more precisely from the distance of the top of the feed section to the bottom of the folding section. In order to be able to adjust this distance ideally, it is provided in a preferred embodiment that the detachable

Pharmaceutical supply component is pivotally mounted.

As already mentioned, the contamination of the surface of the folding and guiding device is problematic and requires that a cleaned surface is provided on a regular basis. This can be done, for example, by the folding and

Guide device, or at least a component of this

Device, is replaced. To the intervals between the

To provide a cleaned surface, it is in a preferred embodiment of the invention

Packaging device provided that the impact area providing surface of the folding and guiding device at least in sections with a non-stick coating

is provided, the adhesion of chipped off

Drug particles difficult. Possibly. flaking

Drug particles are mixed with the drugs in the

folded packaging material web passed and do not remain on the surface.

Alternatively or additionally, it is at another

preferred embodiment provided that the folding and

Guide device is associated with a cleaning device with which on the surface of the folding and guiding device adhering contaminants can be removed. This can be done, for example, by the surface of the folding and guiding device is acted upon by a fluid which rinses the adhering contaminants in the packaging material web. The contaminated area of the packaging material web is assembled as usual into a bag and then disposed of. As cleaning fluid, for example, a

Cleaning fluid can be used. Care must be taken in the design of the cleaning device and the guidance of the cleaning fluid that the contaminant particles are not flushed into other areas of the packaging device.

The packaging material web becomes the folding and

Guiding device provided via the packaging material supply, usually from a supply roll, which may be arranged in a specific section of the packaging device. Particularly in the case of large blister centers, large quantities of medicament are blistered in often repetitive order, so that the supply roll already has finished printed or marked packaging material web areas

can have. In such a case, a spontaneous change of the drug to be packaged is only possible if the

Supply roll is changed with the already marked packaging material web. In order to be packed in terms of

In order to be flexible, it is provided in a preferred embodiment of the packaging device according to the invention that it comprises a marking device, with which the packaging material web corresponding to the packaging or already packaged medicinal products. Usually, corresponding markings are printed on the packaging material web, so that it is preferred that the marking device upstream of the folding and

Guide device is arranged so that a not yet folded packaging material web can be printed.

Hereinafter, an embodiment of the

Packaging device according to the invention described in more detail with reference to the drawing, in which

Figure 1A is an oblique view of the invention

A packaging device having a packaging material web guided through the device;

Figure 1B is an oblique view of the invention

Packaging device without packaging material web shows;

Figures 2A - 2F detail views of the invention

Packaging device in the field of folding and

Show guidance device;

Figures 3A and 3B are side views of the packaging device according to the invention in the field of folding and

Show guidance device;

Figures 4A-4C and 5A-5C are schematic illustrations of the delivery of drugs into the folded

Packaging material web using a conventional

Baffle plate and a folding and

Show guidance device; and

Figures 6A-6F show various views of an embodiment of the folding and guiding device.

FIGS. 1A and 1B are oblique views of FIG

Embodiment of the packaging device according to the invention. In FIG. 1A, the upper area of a packaging material web 2 guided through the device is shown, which covers the

Leaves device as a (only indicated) blister hose 2d. The blister tube is when passing through the

Device formed; how this happens is below

With reference to the following figures explained. In FIG. 1B, the packaging material web and the blister hose are shown

omitted, otherwise the figures are identical. The illustrated embodiment of the invention

Packaging device comprises a supply roll 11, on which a packaging material web 2 is stored, which in the

Passing through the packaging device is formed into bags and filled with drugs. From the supply roll 11, the packaging material web 2 is supplied with a packaging material supply 10 of a folding and guiding device 20, wherein in the embodiment shown between the supply roll and folding and guiding device 20 is still a

Marking device 60 is arranged, with which

Information can be applied to the packaging material web.

With the help of a triangular in this embodiment, folding and guiding device 20 and a subsequent first joining device 40, the packaging material web 2 in

Folded longitudinally to form a U-shaped double track, with the two "legs" of the double track regularly equal or ready are high. How exactly the actual folding of the

Packaging material web and in the same section of

Packing device taking place the folded

Packaging material web is performed, will be described in more detail with reference to subsequent figures.

With the downstream of the folding and guiding device 20th

arranged first joining means 40, the folded and filled with medicines packaging material web is vertical to the longitudinal direction or movement direction X of the

Packing material web (see Figure 1) joined together, wherein a joint area simultaneously represents the beginning of a new (not yet closed) Blisterbeutels and the end of the previous Blisterbeutels. In the embodiment shown, the first joining device 40 is realized by a welding device, with which the folded double web is welded vertically to the longitudinal direction. At the first joining device 40, a cleaning device 29 is attached, with which a cleaning fluid to the surface of the folding and

Guide device 20 can be applied to

Remove impurities from the surface. Downstream of the first joining device 40 is a second

Joining device 50 is arranged, with which the folded

Double track, which is filled with drugs and is already provided with vertical joining areas, parallel to the

Lengthwise and spaced from the folding of the

Packaging material web is joined together, which is realized in the embodiment shown again by a weld. The finished blister hose 2d is led out of the blister machine and an inspection and

(For example, patient-related) separation supplied.

Figures 2A-2E show detailed views of a

Embodiment of the packaging device according to the invention in the region of the folding and guiding device 20. As can be seen in Figure 2A, the packaging material web 2 by means of the folding and guiding device 20 and the first

Joining device 40 folded to a double web 2c.

For this purpose, the unfolded packaging material web 2 is guided under a triangular folding and guiding device 20 in a packaging material web receiving region 21. Occur at the side areas of the folding and guiding device

Sections 2a, 2b of the packaging material web 2 forth. At the (not visible in Figure 2A) tip of the folding and

Guide means 20 determines the fold area, i. the area where the actual folding of the

Packaging material web takes place. The folding of the double web is maintained by the folding and guiding device 20 downstream first joining device 40.

Figure 2A also shows some details of the first

Joining device 40, namely two vertically to the longitudinal direction or direction of movement of the packaging material web (or.

Dual web) aligned welding rollers 41, 42, with which vertical to the longitudinal direction of the packaging material web

directed welding areas or joining areas are formed.

In the case of deflashing, the welding rollers 41, 42 rotate, the speed of rotation being related to the length of the bag and

Movement speed of the packaging material web is adapted or will. In the illustrated embodiment Each welding roller has two opposed welding sections 41a, 41b, 42a, 42b (see Fig. 2B) and only in these areas do the welding rollers make contact with the double track between them during rotation. The welding sections are coordinated so that when moving the

Double track and rotation of the welding rollers these all X cm come into contact with the double track and form a joint area 4. The distance of "non-contact" between

Welding sections and double track defines the length of the

Blister bag.

The illustration according to FIG. 2B serves only for

Illustration of the rollers / contact areas. As can be seen, the joining region in the direction of movement of the

Packaging material web at the height of the axes of

Welding rolls, i. Joining area 4 became "straight"

brought in; the rollers would have to be rotated by 90 ° C to reproduce this just happened welding. For clarity, however, this representation is selected.

As already indicated, the folding and

Guide device 20 be executed in several parts and have a releasable drug delivery component and a folding component. In FIG. 2C, the detachable drug delivery component 26 has been omitted and only the triangular fold component 27 that has just been formed can be seen. In this figure, it can also be seen that the

Packaging material web 2, after being at the

Packaging material receiving portion 21 has been guided under the folding and guiding device 20, in the other two side regions of the folding and guiding device, the

so-called packaging material web folding areas, of which only the "right" in the direction of movement

Packaging material web folding area 22a can be seen, emerge.

In Figure 2D, the complete folding and

Guide device 20 is shown, however, is the

Packaging material web 2 omitted, and in this The illustration shows the "left" packaging material web folding region 22b.

In FIG. 2E, in order to illustrate the folding, the first joining device is omitted in order to define the region in which the folded packaging material web regions 2a, 2b

meet, to illustrate, this area 6 is only schematically represents. For example

indicated that the packaging material web portions 2a, 2b in the area 6 converge pointedly, which is not quite true in practice, since the area is constantly filled with drugs that deform the area.

The packaging material web / double track is at the

Blinding moved by the packaging device, and with the web also moves the joining area (in the direction of

Arrow). The folded packaging material web and the folding and guiding device 20 form a kind of funnel, and in this funnel to be restrained drugs on the folding and guiding device passed (see also Figure 3B).

In the illustration shown in FIG. 2F, both the first joining device and the packaging material web / double web are omitted, and it is the same according to the invention

designed folding and guiding device 20 to recognize. In the illustrated embodiment, the folding and guiding device 20 is constructed in two parts, with a lower folding member 27 and an upper drug delivery member 26, wherein the

Drug delivery member is releasably secured to the folding member. In the illustrated embodiment, the drug delivery member 26 provides an impact area 24 from which to package drugs to be delivered to the packaging area.

As can be seen in FIG. 2F, the two run

Packaging material web folding areas 22a, 22b, which are provided in the present case by the folding member 27, in the folding portion 23 together, the folding area of the

Packaging material web defined. The medicament supply component 26 has the medicament in the region of the tip. Feeding portion 25 which is formed by the folding portion 23 vertically (up) spaced. Furthermore, it can already be assumed in FIG. 2F that the surface of the drug delivery component 26 is concave.

Figures 3A and 3B show side views of the

Packaging device according to the invention in the region of the folding and guiding device 20. In Figure 3A, the first

Joining device omitted to illustrate the course of the unfolding of the packaging material web 2 from the side. In this illustration, it can be seen that the folding and

Guide device itself is arranged inclined in the packaging device, and the unfolded packaging material web 2c after folding also inclined further passed through the device.

FIG. 3B shows a further side view of FIG

inventive packaging device, wherein in this

Representation of a part of the unfolded packaging material web, the area 2b of Figure 3A, is omitted, so that the folding and guiding device 20 can be seen. In the illustration according to FIG. 3B, a plurality of medicaments 7 are also shown in order to supply the medicaments 7 into the packaging region 6 as well as the arrangement of individual medicaments

To illustrate drugs in a (still finished) blister bag (limited by joining areas 4a, 4b).

The provided drug combination is fed via a feed 5 of the folding and guiding device 20, which they impinge on in the impact area 24. The concave configuration of the surface of the folding and guiding device 20, which in the embodiment shown consists of the drug delivery component 26 and the folding component 27, means that the angle in the impact region is steeper in comparison with a non-concave surface, So that the

Drugs are accelerated more. In the region of the tip of the folding and guiding device 20, the medicament supply section 25 is formed, vertically spaced from the folding section 23. The embodiment of the folding and guiding device according to the invention requires that the medicaments 7 not be supplied to the packaging area 6 in the area of the fold 3, but, with respect to the direction of movement of the packaging material web, vertically spaced from the

Faltbereich 3. The inventive folding and

Guide means forms a kind of ski jump (this effect is enhanced by the concave configuration of the surface), with the result that the drug 7 is not easy

are stored one behind the other in the folding area 3, but "jump" in the packaging area 6. In the packaging area they bounce, in the "snapshot" just shown, against the vertical joining area 4a and then fall in the direction of folding area 3. In this way, drugs can not only one behind the other (in the direction of movement of

Packaging material web), but also be stacked, which means that the same number of drugs can be packaged in a smaller blister bag. A correspondingly produced blister bag is shown in FIG. 3B "on the left" of the joining area 4a. It can also be seen that a joining region 4a for the currently produced

Blisterbeutel the "beginning" and for the previous one

Blister bag represents the bag end.

The exact way of storing the drug in the

Packaging range depends on the medicines themselves and the length of the blister pack. In the state shown, the drugs collide at the joining area and then fall down. When moving the packaging material web, in which the joining region 4a moves on to the left, it may also happen that the drugs no longer bounce off the joining region, but simply spaced in the direction of movement in the

Packaging area arise.

Figures 4A-4C and 5A-5C show schematically the

Difference in the production of Blisterbeuteln with a known baffle plate and a folding and guiding device according to the invention, wherein the figures 4A - 4C, the preparation with a known baffle plate 20 ^λ .

Figures 6A - 6D show various views of an embodiment of a folding and Guide means 20, wherein the embodiment shown comprises a drug delivery member 26 and a folding member 27.

In the illustrated embodiment, the folding member 27 is formed as a flat triangular plate. In particular, however, the underside of the folding component can also be designed completely differently in other embodiments.

In the figures, in particular Figure 6C, the concave configuration of the surface of the drug delivery member 26 is clearly visible. Furthermore, the packaging material web receiving region 21 as well as the packaging material web folding regions 22a, 22b can be seen, which are shown in FIG

Embodiment of the folding member 27 are provided.

It can be seen in FIGS. 6E and 6F that the

Pharmaceutical supply component can be designed to be pivotable to the folding component, whereby an adjustment of the folding and

Guide device to be packed or to

Remedies possible.

Claims

claims

A pharmaceutical packaging apparatus (1) comprising a packaging material feeder (10) for feeding a flexible, elongated packaging material web (2) from one

Supply roll (11),

a downstream of the packaging material supply (10) arranged folding and guide means (20) with a

Packaging material web receiving area (21) and two

Packaging material web folding areas (22a, 22b), which in one

Faltabschnitt (23) converge, wherein the folding and

Guiding device (20) the packaging material web (2) in

Folds longitudinally by the edges of the

Packaging material web are guided along the packaging material web folding areas (22a, 22b) and the

Faltabschnitt (23) a folding area (3) in the

Packing material web (2) determines, and wherein the folding and

Guide device (20) has a collision area (24) for medicaments to be packaged,

a first joining device (40) arranged downstream of the folding and guiding device (20), with which the folded packaging material web (2) is vertical to the

Longitudinally joined together,

a second joining device (50) arranged downstream of the folding and guiding device (20), with which the folded packaging material web (2) runs parallel to

Longitudinally joined together,

wherein the folding and guiding means (20) one of the

Faltabschnitt (23) spaced drug delivery section (25) over which drug vertically spaced from the fold region (3) in the folded

Packaging material web (2) are passed.

2. Packaging device (1) for pharmaceutical after

Claim 1, characterized in that the Impact region (24) providing surface of the folding and guiding device (20) is concave.

3. Packaging device (1) for medicines

Claim 1 or 2, characterized in that the folding and guiding device (20) has a detachable drug delivery component (26) and a folding component (27), wherein the delivery portion (25) is part of the detachable drug delivery component (26). and the folding portion (23) is part of the folding member (27).

4. Packaging device (1) for drugs

Claim 3, characterized in that the detachable

Pharmaceutical supply member (26) is pivotally mounted such that the feed section (25) of the drug delivery member (26) with respect to the folding region (3)

is height adjustable.

5. Packaging device (1) for medicaments according to one of claims 1 - 4, characterized in that the

Impact region (24) providing surface of the folding and guiding device (20) is at least partially provided with a non-stick coating (28).

6. Packaging device (1) for medicaments according to one of claims 1-5, characterized in that the folding and guide device (20) is associated with a cleaning device (29) with which on the surface of the folding and guiding device (20) adhering Impurities can be removed.

7. Packaging device (1) for medicaments according to one of claims 1-6, characterized in that the

Packaging device (1) a preferably upstream of the folding and guiding device (20) arranged

Marking device (60).