WO2016068532A1 - Exothermic oral composition - Google Patents

Abstract

The present invention relates to an exothermic oral composition comprising an anhydrous zeolite, a polyol and a binder.

Description

Fever composition for oral cavity

The present invention relates to a pyrogenic composition for oral cavity.

This application claims the benefit of the application date of Korean Patent Application No. 10-2014-0149863 filed with the Korean Intellectual Property Office on October 31, 2014, the entire contents of which are incorporated herein.

Toothpaste, which is used to remove foreign substances such as tartar on the tooth surface, is used for the purpose of preventing tooth decay by containing fluoride, which is a typical tooth decay preventive agent. Agonists, abrasives, etc. are used as a main component.

In addition to the purpose of preventing tooth decay, in order to prevent periodontal disease that causes inflammation of the gums and destroys periodontal tissues, such as gingivitis and periodontal disease such as periodontal disease, additives for promoting blood circulation of the gum are used.

U.S. Patent No.4647451 discloses a technique for preparing a toothpaste having a heat-generating property using anhydrous zeolite, and when the anhydrous zeolite comes into contact with moisture, such as saliva, in the oral cavity, By the heat generated to feel a sense of warmth, promote blood circulation of the gums.

However, U.S. Patent No.4647451 used deacetylated heteropolysaccharide S-60 as a binder with an anhydrous zeolite, but it was not secured as a toothpaste.

In addition, in the past, the pasty toothpaste prevents separation of the abrasive and the liquid component, maintains the shape retention of the preparation, and provides a viscosity, and adjusts the foaming agent in the past. The use of a humectant is required to provide adequate moisture and plasticity and to prevent dry solidification of the toothpaste.

Therefore, in the case of an exothermic toothpaste containing anhydrous zeolite, stability of the composition is required so as to include a humectant, so that a viscosity is maintained and a two-liquid phenomenon in which a solid phase and a liquid phase are separated does not occur.

In addition, a technique for providing warmth when brushing teeth using anhydrous calcium chloride having excellent exothermic properties during hydration is known, but calcium chloride has a unique bitter taste, which is problematic in actual application to toothpaste.

The inventors of the present invention contain anhydrous zeolite, have exothermic properties in the oral cavity, while providing a moisture and plasticity suitable for the formulation by containing a humectant, while maintaining the viscosity even for long-term storage, the two-liquid phenomenon that the solid phase and liquid phase is separated An improved pyrogenic composition for oral cavity is provided.

In order to achieve the above object, the present inventors provide an oral exothermic composition comprising anhydrous zeolite, polyol and a binder.

Oral heating composition according to the present invention contains anhydrous zeolite, while having an exothermic property in the oral cavity, containing a humectant to provide moisture and plasticity suitable for the preparation, while maintaining viscosity even for long-term storage, solid and liquid This separating liquefaction phenomenon is suppressed.

In addition, the oral exothermic composition according to the present invention contains an anhydrous zeolite, even in anhydrous formulation, the taste is relatively good at the time of brushing, and also excellent exothermic properties.

The present invention provides an oral exothermic composition comprising anhydrous zeolite, polyol and a caking additive.

The exothermic composition for oral cavity of the present invention generates heat when reacted with water, including anhydrous zeolite, so that you can feel the heat when using the toothpaste, unlike the case of containing anhydrous calcium chloride, which has a bad feeling of use because of its strong bitterness and salty taste, It is not bitter and salty, so it has excellent feeling.

In one embodiment of the invention, the anhydrous zeolite is not particularly limited as long as generating heat by reaction with water, for example zeolite A, zeolite X, zeolite Y, formulas such as zeolite L xM _{2 / n} O · Al ₂ O ₃ ySiO ₂ ZH ₂ It is an anhydride of a zeolite represented by O (where x, y and z represent arbitrary numbers, M represents an alkali metal or alkaline earth metal, and n represents its valency).

In one embodiment of the present invention, the polyol is any one or more selected from the group consisting of glycerin, propylene glycol, butylene glycol, dipropylene glycol and polyethylene glycol. The polyol may be exothermic while hydrated in the anhydrous form, and in particular, polyethylene glycol is preferred because of its excellent exothermic ability.

In one embodiment of the present invention, the binder is any one or two or more selected from the group consisting of polyvinylpyrrolidone, an acrylate polymer and a polyoxyethylene-polyoxypropylene-polyoxyethylene copolymer.

In the case of a conventional toothpaste, since a large amount of water is formulated, water-soluble polymers are used as a caking agent, but since the zeolites contained in the present invention should be anhydrous in order to maintain exothermic properties, the water-soluble polymers that act only in aqueous solution are desired While no effect can be obtained, polyvinylpyrrolidone, an acrylate polymer, polyoxyethylene-polyoxypropylene-polyoxyethyl and combinations thereof have excellent effects as a binder even in anhydrous formulations.

The acrylate-based polymer may be specifically polyacrylate or sodium acrylate, and more specifically, may be trade name Carbopol 980 or trade name Carbopol 940 manufactured by Lubrizol Corporation.

The polyoxyethylene-polyoxypropylene-polyoxyethylene (PEG-PPG-PEG) block copolymer has a molecular weight (polyoxypropylene molecular mass) of 4,000 g / mol of the PPG block, polyoxyethylene is the entire PEG-PPG-PEG block It may be 70% by mass relative to the mass of the copolymer, specifically Poloxamer 407, and more specifically Pluronic F127 or Croda manufactured by BASF. Synperonic PE / F 127 manufactured by the company.

The polyoxyethylene-polyoxypropylene-polyoxyethylene (PEG-PPG-PEG) block copolymer has a molecular weight (polyoxypropylene molecular mass) of 4,000 g / mol of the PPG block, polyoxyethylene is the entire PEG-PPG-PEG block It may be 80% by mass relative to the mass of the copolymer, specifically Poloxamer 188, more specifically the trade name Pluronic F68 or Croda manufactured by BASF. May be a brand name Synperonic PE / F 127 (Synperonic PE / F 68).

In one embodiment of the present invention, the content of the anhydrous zeolite is 5% by mass or more and 50% by mass or less with respect to the total composition mass. When the content of the anhydrous zeolite is 5% by mass or less, the effect of fever is hardly felt when brushing, and when 50% by mass or more, there is a problem of feeling pain when brushing due to excessive heat.

In one embodiment of the present invention, the content of the polyol is 30% by mass or more and 80% by mass or less based on the total composition mass. If the content of the polyol is 30 mass% or less, the formulation becomes too hard due to excessive powder content, and at 80 mass% or more, there is a problem in formulation that the amount of powder that can be blended in the formulation is too small due to the excessive polyol content.

In one embodiment of the present invention, the content of the binder is 0.1% by mass or more and 5% by mass or less with respect to the total composition mass. If the content of the binder is 0.1% by mass or less, the phase separation phenomenon during long-term storage could not be suppressed, and in the case of 5% by mass or more, the increase was excessive, making it difficult to mix during manufacture and filling the container with the composition.

In one embodiment of the present invention, the oral pyrogenic composition is any one or two or more selected from the group consisting of caries preventive agent, periodontal disease prevention agent, symptomatic relaxant, tooth whitening agent, abrasive, foaming agent, flavoring agent, sweetening agent and preservative It includes more.

The caries preventive agent may be any one or two or more selected from the group consisting of sodium monofluorophosphate, sodium fluoride and tin fluoride.

The periodontal disease preventive agent in the group consisting of allantoin, di-cichlic acid dipotassium, ε-aminocaproic acid, tranexamic acid, hinoxylol, tranexamic acid, hydroxylol, lysozyme, vitamin E, derivatives of vitamin E and sodium chloride It may be any one or more than one selected.

Said relaxant may be any one or two or more selected from the group consisting of calcium nitrate, tricalcium phosphate and strontium chloride.

The abrasive may be any one or two or more selected from the group consisting of heavy calcium carbonate, precipitated calcium carbonate and silica.

The foaming agent may be sodium lauryl sulfate.

The flavoring agent may be menthol and / or peppermint oil.

The sweetener may be any one or two or more selected from the group consisting of saccharin, stevioside and xylitol. The saccharin may be sodium saccharin or calcium saccharin.

The preservative may be methyl paraoxybenzoate and / or butyl benzoate.

The tooth whitening agent may be any one or two or more selected from the group consisting of hydrogen peroxide solution, urea peroxide, calcium peroxide .

The present invention provides a toothpaste comprising the above-described heating composition for oral cavity.

In one embodiment of the present invention, the toothpaste may be powder toothpaste, liquid toothpaste or liquid toothpaste.

Hereinafter, the configuration and effects of the present invention will be described in more detail with reference to test examples and formulation examples. However, these test examples and formulation examples are provided only for the purpose of illustration to help the understanding of the present invention is not limited to the scope and scope of the present invention by the following examples.

Preparation Example 1 Confirmation of Compatibility of Polyols and Caking Agents

Toothpaste compositions of Examples 1 to 3 and Comparative Examples 1 to 6 were prepared in the composition shown in Table 1 below. Perfumes, sodium saccharin, sodium monofluorophosphate and caking additives (carbopol, polyvinylpyrrolidone, poloxamer, cellulose gum, etc.) were dissolved or dispersed in polyol polyethylene glycol and glycerin. In addition, an inorganic powder such as calcium carbonate, hydrous silicic acid, anhydrous zeolite or calcium chloride and sodium lauryl sulfate were added and mixed in a vacuum to prepare a toothpaste composition.

As the carbopol, a trade name Carbopol 940 manufactured by Lubrizol corporation was used, and as the polyvinylpyrrolidone, trade name LUVISCOL K30 manufactured by BASF was used, and BASF as the poloxamer. The brand name Lutrol F127 manufactured by (BASF) was used.

Table 1

ingredient	Example 1	Example 2	Example 3	Comparative Example 1	Comparative Example 2	Comparative Example 3	Comparative Example 4	Comparative Example 5	Comparative Example 6
Calcium carbonate	35.00	35.00	35.00	35.00	35.00	35.00	35.00	35.00	35.00
Function	5.00	5.00	5.00	5.00	5.00	5.00	5.00	5.00	5.00
Zeolite anhydrous	10.00	10.00	10.00	10.00	10.00	10.00	10.00	10.00	10.00
Polyethylene glycol	25.44	24.94	24.94	25.94	25.94	25.94	25.94	25.94	25.94
glycerin	20.00	20.00	20.00	20.00	20.00	20.00	20.00	20.00	20.00
Spices	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
Sodium Lauryl Sulfate	2.00	2.00	2.00	2.00	2.00	2.00	2.00	2.00	2.00
Sodium saccharin	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30
Sodium monofluorophosphate	0.76	0.76	0.76	0.76	0.76	0.76	0.76	0.76	0.76
Cabopol	0.50
Polyvinylpyrrolidone		1.00
Poloxamer			1.00
Cellulose gum				1.00
Carrageenan					1.00
Xanthan Gum						1.00
Methyl Cellulose							1.00
Hydroxyethyl Cellulose								1.00
Polyvinyl alcohol									1.00

* Unit:% by mass relative to the total composition

Test Example 1 Formulation Stability

(1) viscosity change

About 100 g of the toothpaste composition prepared in Examples and Comparative Examples was placed in a 100 ml beaker and measured for 1 minute at a speed of spindle D, 0.5 rpm with a Brookfield viscometer to obtain the results shown in Table 2 below.

TABLE 2

	Example 1	Example 2	Example 3	Comparative Example 1	Comparative Example 2	Comparative Example 3	Comparative Example 4	Comparative Example 5	Comparative Example 6
Initial viscosity	240000	100000	80000	12000	4000	8000	12000	8000	4000
Next day	920000	440000	1040000	20000	12000	20000	8000	12000	12000
1 month later	1000000	640000	1080000	16000	8000	20000	8000	8000	12000

* Unit: cps

Looking at Table 2, using Carbopol, polyvinylpyrrolidone, poloxamer as a binder each of the initial viscosity of 80,000 cps or more, after the next day viscosity of 104,000 cps or more, unlike Examples 1 to 3, different as a binder In the case of Comparative Examples 1 to 6 using the component, it can be confirmed that the binder hardly contributes to the viscosity formation.

(2) phase separation

The toothpaste composition prepared in Preparation Example 1 was stored in a room temperature, 45 ° C. oven, a cycling oven (varied to a temperature range of −10 to 45 ° C.), and after one month, phase separation was evaluated.

<Evaluation Criteria>

Good: No phase separation

Medium: Very weak phase separation

Poor: severe phase separation.

TABLE 3

	Example 1	Example 2	Example 3	Comparative Example 1	Comparative Example 2	Comparative Example 3	Comparative Example 4	Comparative Example 5	Comparative Example 6
Room temperature	Good	Good	Good	Bad	Bad	Bad	Bad	Bad	Bad
45 ℃	usually	Good	Good	Bad	Bad	Bad	Bad	Bad	Bad
Cycling	usually	Good	usually	Bad	Bad	Bad	Bad	Bad	Bad

Looking at the Table 3, as a result of the phase separation evaluation, it can be confirmed that Example 2 using the polyvinylpyrrolidone is the best formulation stability, it was also possible to use Example 1 using Carbopol and Example using poloxamer. . However, it can be seen that all other binders are difficult to use due to separation phenomena.

Preparation Example 2 Usability Check

Toothpaste compositions of Examples 2 and 4 and Comparative Examples 7 and 8 were prepared in the compositions shown in Table 4 below.

Table 4

ingredient	Example 2	Example 4	Comparative Example 7	Comparative Example 8
Calcium carbonate	35.00		35.00	35.00
Function	5.00	5.00	5.00	5.00
Zeolite anhydrous	10.00	50.00
Calcium chloride				10.00
Polyethylene Glycol 400	24.94	19.94	34.94	24.94
glycerin	20.00	20.00	20.00	20.00
Spices	1.00	1.00	1.00	1.00
Sodium Lauryl Sulfate	2.00	2.00	2.00	2.00
Sodium saccharin	0.30	0.30	0.30	0.30
Sodium monofluorophosphate	0.76	0.76	0.76	0.76
Polyvinylpyrrolidone	1.00	1.00	1.00	1.00

* Unit:% by mass relative to the total composition

[ Test Example 2] feeling  evaluation

In this test, to evaluate the feeling of use of the toothpaste prepared in each Example and Comparative Example, a feeling of evaluation was performed.

The survey was conducted on 40 male and female consumers in their 20s and 50s after one week of use, and the results are shown in Table 5.

<Evaluation Criteria>

Warm: very strong 5, strong 4, normal 3, almost no 2, no 1

Bitter taste: very strong 5, strong 4, normal 3, almost no 2, no 1

Stimulation: very strong 5, strong 4, normal 3, almost no 2, no 1

Satisfaction: very good 5, good 4, normal 3, bad 2, very bad 1

Table 5

Usability Index (5-point scale)	Example 2	Example 4	Comparative Example 7	Comparative Example 8
Warmth	3.7	4.8	1.1	3.8
bitter	3.2	3.3	2.7	4.9
Stimulation	3.1	4.2	2.1	4.8
satisfaction	4.3	3.7	3.1	1.3

In the case of Comparative Examples 7 and 8 using calcium chloride, the satisfaction was extremely low even with a relatively high heat feeling due to the very bitter taste and irritation. On the other hand, Example 4 containing 50% by mass of anhydrous zeolite feels a great sense of warmth, but it can be seen that the stimulus increases accordingly, and the overall satisfaction is excellent in Example 2 containing 10% by mass of anhydrous zeolite. Can be.

Claims (7)

1. An oral exothermic composition comprising anhydrous zeolite, polyol and caking additive.
2. The method of claim 1, wherein the polyol is glycerin, propylene glycol, butylene glycol, dipropylene glycol, and any one or more selected from the group consisting of polyethylene glycol oral exothermic composition.
3. The method of claim 1, wherein the binder is any one or two or more selected from the group consisting of polyvinylpyrrolidone, an acrylate-based polymer and a polyoxyethylene-polyoxypropylene-polyoxyethylene block copolymer Fever composition for oral cavity.
4. The oral heating composition according to claim 1, wherein the content of the anhydrous zeolite is 5% by mass or more and 50% by mass or less with respect to the total composition mass.
5. The oral heating composition according to claim 1, wherein the content of the polyol is 30 mass% or more and 80 mass% or less with respect to the total composition mass.
6. The oral heating composition according to claim 1, wherein the content of the binder is 0.1% by mass or more and 5% by mass or less with respect to the total composition mass.
7. A toothpaste composition comprising the fever composition for oral cavity of claim 1.