WO2016013949A3 - Biomimetic gellable colloid for encoding, processing and sectioning histological samples - Google Patents

Biomimetic gellable colloid for encoding, processing and sectioning histological samples Download PDF

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Publication number
WO2016013949A3
WO2016013949A3 PCT/RO2015/000003 RO2015000003W WO2016013949A3 WO 2016013949 A3 WO2016013949 A3 WO 2016013949A3 RO 2015000003 W RO2015000003 W RO 2015000003W WO 2016013949 A3 WO2016013949 A3 WO 2016013949A3
Authority
WO
WIPO (PCT)
Prior art keywords
colloid
sectionable
gellable
sectioning
processing
Prior art date
Application number
PCT/RO2015/000003
Other languages
French (fr)
Other versions
WO2016013949A2 (en
Inventor
Sorin Musat
Original Assignee
FLOREA, Ileana Maria
MUŞAT, Daniela
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FLOREA, Ileana Maria, MUŞAT, Daniela filed Critical FLOREA, Ileana Maria
Publication of WO2016013949A2 publication Critical patent/WO2016013949A2/en
Publication of WO2016013949A3 publication Critical patent/WO2016013949A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis

Abstract

The present invention refers to a biomimetic gellable colloid with customizable composition which may be used as a sectionable support for encoding, processing and microtome sectioning of histological specimens for diagnostic examination. The gellable colloid has a uniformly dispersed phase, it comprises a hydrophilic component and may be gelled upon demand. The colloid may be a nanocolloid or a microcolloid. It may also optionally comprise a hydrophobic component. The hydrophilic component comprises at least a protein component and/or a polymerizable carbohydrate and/or a pre- polymerized carbohydrate, in an aqueous phase. The invention also refers to a process for preparing said gellable colloid, a sectionable matrix configured to handle processing and sectioning of histological samples obtained from said gellable colloid, methods for preparing such a sectionable matrix. The invention also discloses a sectionable code for unambiguous and irreversible identification of histological preparations and the use of a gellable colloid to obtain such a sectionable code.
PCT/RO2015/000003 2014-01-28 2015-01-28 Biomimetic gellable colloid for encoding, processing and sectioning histological samples WO2016013949A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
RO201400075 2014-01-28
ROA201400075 2014-01-28
RO201400078 2014-01-29
ROA201400078 2014-01-29

Publications (2)

Publication Number Publication Date
WO2016013949A2 WO2016013949A2 (en) 2016-01-28
WO2016013949A3 true WO2016013949A3 (en) 2016-05-12

Family

ID=55073086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RO2015/000003 WO2016013949A2 (en) 2014-01-28 2015-01-28 Biomimetic gellable colloid for encoding, processing and sectioning histological samples

Country Status (1)

Country Link
WO (1) WO2016013949A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3580764A4 (en) * 2017-02-09 2020-11-11 Leavitt Medical, Inc. Systems and methods for tissue sample processing
US11129790B2 (en) 2017-05-19 2021-09-28 Northeastern University Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates
WO2023081329A1 (en) * 2021-11-04 2023-05-11 The Trustees Of Princeton University 3d-printing engineered living materials

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2800457A (en) * 1953-06-30 1957-07-23 Ncr Co Oil-containing microscopic capsules and method of making them
US3405071A (en) * 1963-12-30 1968-10-08 Ibm Process of making microcapsules
WO2005089564A1 (en) * 2004-03-19 2005-09-29 Danisco A/S Emulsifier composition for shortening
WO2013002661A1 (en) * 2011-06-29 2013-01-03 Musat-Marcu Sorin Matrix for receiving a tissue sample and use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2800457A (en) * 1953-06-30 1957-07-23 Ncr Co Oil-containing microscopic capsules and method of making them
US3405071A (en) * 1963-12-30 1968-10-08 Ibm Process of making microcapsules
WO2005089564A1 (en) * 2004-03-19 2005-09-29 Danisco A/S Emulsifier composition for shortening
WO2013002661A1 (en) * 2011-06-29 2013-01-03 Musat-Marcu Sorin Matrix for receiving a tissue sample and use thereof

Also Published As

Publication number Publication date
WO2016013949A2 (en) 2016-01-28

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