WO2015161392A1 - Concentrated cleaning composition comprising copper and mentha piperita extract,for cleaning all types of surfaces for household and industrial use - Google Patents

Concentrated cleaning composition comprising copper and mentha piperita extract,for cleaning all types of surfaces for household and industrial use Download PDF

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Publication number
WO2015161392A1
WO2015161392A1 PCT/CL2015/000024 CL2015000024W WO2015161392A1 WO 2015161392 A1 WO2015161392 A1 WO 2015161392A1 CL 2015000024 W CL2015000024 W CL 2015000024W WO 2015161392 A1 WO2015161392 A1 WO 2015161392A1
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weight
composition
concentration
copper
cleaning composition
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PCT/CL2015/000024
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Spanish (es)
French (fr)
Inventor
Alejandra Arlette PUEBLA DUHALDE
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Importadora Soviquim Ltda.
Sociedad Legal Minera La Coqueta Dos Uno De Rio Hurtado
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Publication of WO2015161392A1 publication Critical patent/WO2015161392A1/en

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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • A01N65/22Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02Anionic compounds
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02Inorganic compounds ; Elemental compounds
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/382Vegetable products, e.g. soya meal, wood flour, sawdust
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/50Perfumes

Definitions

  • Concentrated cleaning composition with Copper and Mentha Piperita extract for cleaning all types of household and industrial use surfaces
  • the present invention relates to a cleaning composition with copper and mentha piperita extract, a process for its preparation, its use and application in the cleaning of all types of surfaces, such as floors, walls, work tables, handrails, ceramic surfaces, tiles, plastics, for home and industrial use.
  • cleaning compositions are known in the art, the need to use products, which serve a dual purpose, to clean and disinfect at the same time, facilitating the daily work of people, has increased in recent years, being common in surface cleaning processes, the use of various detergent and disinfection compositions separately, which require optimal environmental conditions, to obtain satisfactory results, this objective is not met, in most cases, due to the presence of organic matter , and a high concentration of pathogenic microorganisms that exist in the environment, such as bacteria, viruses, and fungi, which have the power to adapt quickly to the chemical and biological structures of cleaning and disinfectant agents, generating bacterial resistance, this has as a consequence direct, increasing and permanent increase in the doses of use of cleaners and disinfectants, c A final consequence can be clearly observed in hospital enclosures, in the food industry, or in large-flowed areas of people, where the resistance of bacteria such as Escherichia Coli, Listeria, Speudomonas, among others, has caused epidemic outbreaks of difficult control elimination.
  • the cleaning composition concentrated with copper and mentha piperita extract improves the problem of bacterial resistance, which occurs in the permanent use of disinfectants and cleaners, providing in a single concentrated composition, a cleaning agent , an antibacterial agent of copper salts and peppermint extract, complementary agent in the reduction of bacterial load, this contributes to the residual effects of the cleaning composition.
  • mentha piperita eliminates bacteria such as E. coli, S. aureus, Pseudomonas aeruginosa, S. faecalis, Klebsiella pneumoniae, various scientific studies have shown In addition, mentha piperita has antiparasitic effects on different ectoparasites, such as H. tuberculatus, Musca domestica, Stomoxys calcitrans, Haematobia irritans, Hippobosca equina, Culex quinquefasciatus and pipiens, Aedes aegypti.
  • the objective of this invention is to provide a concentrated cleaning composition with copper and mentha piperita extract, which allows cleaning of all types of surfaces, such as floors, walls, inns, food preparation rooms, helping to reduce the presence of pathogenic microorganisms, in highly contaminated enclosures, food factories, hospital enclosures, schools, industries in general, providing a better process of cleaning the treated surfaces.
  • the detergent composition volatile elements, it allows to maintain a residual effect over time, which increases the antibacterial effect of the cleaning composition, also reduces environmental pollution, by reducing the odor emissions of the enclosures, where they work animals, such as slaughterhouses, agricultural enclosures, veterinarians, among others, contributing to improve the quality of life of people.
  • the cleaning composition concentrated with copper and mentha piperita extract, of the present invention is characterized by containing a copper salt by weight of 3% to 15%, given its high concentration, provides the cleaning composition with an antibacterial effect, increasing its residual effects over time, it also contains 0.5-1% by weight of mentha piperita extract, which enhances the antibacterial effects of copper, acting as a complementary agent in the reduction of pathogenic microorganisms, 10 to 40% by weight of a surfactant surfactant Sodium Lauryl Sulfate short chain with 12 to 14 Carbon atoms (C12-C14, SLES), which provides a high degree of cleanliness, adequate levels of foam, widely used in soap, shampoo formulations, among other preparations for cosmetic and industrial use, the cleaning preparation with copper and mint extract, also contains 4 to 8% by weight of a thickening agent Chloride of Sodium food grade, 0.5 to 3% by weight, of a fragrance or perfume essence of lemon, mint, apple, lavender, or other, demineralized water sufficient quantity for 100% by weight of components.
  • the cleaning composition with copper and mentha piperita extract is presented as a liquid preparation, slightly viscous, whose field of application, is intended for cleaning all types of surfaces, for home and industrial use, such as cleaning of ceramics, tiles, tiles, linoleum, in floors and walls, in hospital rooms, process plants, fast food facilities, means of transport, private homes, schools, etc.
  • the cleaning composition with copper and mentha piperita extract due to its high concentration of copper salts, improves the physicochemical characteristics of cleaners existing in the market, known in the art, and which are related to the subject, such as for example, Japanese patents C11D1 / 29, A61K8 / 00, US patent US4024078, CllD17 / 00 where the ion copper, together with other metal ions such as manganese, zinc, tin, silver, are in low concentrations, as additives, for the removal of grease stains, low concentrations of copper in said compositions limit and reduce the antibacterial effect, against high concentrations of organic matter and the resistance of pathogenic microorganisms of the environment.
  • the inhibitory activity of copper depends on its concentration, on the presence or not of copper binding proteins, as in the case of Vibrio alginolyticus, which can survive in high concentrations of copper, bacteria such as Staphylococcus Aureus, die in low concentrations of biocides , widely used to disinfect, in hospital enclosures, that is why the copper concentrated cleaning composition proposed in this invention patent is enhanced, by containing in its formulation, mentha piperita, whose effects on the reduction and inhibition of pathogenic microorganisms have been studied by the international scientific community.
  • the permanent struggle in high-flow precincts of people, such as hospitals, food industries, public and private institutions, to avoid and reduce the resistance of pathogenic microorganisms, is often unsuccessful, generating epidemic outbreaks of difficult control.
  • Antibacterial agents used in cleansers, disinfectants and antiseptics in low doses, cause bacteria and viruses to form biofilms, which are clusters of microorganisms coated with extracellular polymers that serve to protect microorganisms, allowing them to survive and Become resistant to cleaners and disinfectants.
  • the World Health Organization (WHO), the United States Environmental Protection Agency, which in studies in conjunction with the Medical University of South Carolina, United States, which in 2011, determined through clinical studies that Copper eliminates over 90% of microbial agents, copper also has the ability to inhibit the growth of pathogenic microorganisms rapidly at refrigeration (4 ° C) and environmental (20 ° C) temperatures, over a period of four hours.
  • Copper due to its ability to attack the cell wall, and to penetrate inside the cells of microorganisms, prevents the transport of basic nutrients, causing cell death and therefore of microorganisms, also achieving a lower adaptation and resistance In time, it is considered an important element for the control of pathogenic microorganisms, recognizing Copper as a bactericidal metal.
  • the cleaning composition concentrated with copper and mentha piperita extract does not contain volatile solvents such as Ethyl or Isopropyl Alcohol, which allows maintaining a residual effect of copper over time, increasing the latency periods of the cleaning process, where traditional cleaners do not act, due to the low concentrations of antibacterial elements, in addition to the concentrated cleaning composition, has a high level of detergency, which allows high performance at a lower cost.
  • Concentrations of the copper cleaning composition between 20% and 95% by weight, inhibited the bacterial growth of Escherichia Coli and Staphylococcus Aureus in average range less than 1 CFU / ml, by being in contact with the copper cleaning composition for a period of 5 to 10 minutes, compared to the blank, without the copper cleaning composition, which presented bacterial growths of 1.2 x 10 6 CFU / ml and 3.6 x 10 7 CFU / ml respectively.
  • the present invention is further related to a method of manufacturing said composition, which is characterized primarily by dissolving copper salts in an aqueous solution, the concentration of which is between twenty thousand parts per million and three hundred thousand parts per million by weight , proceed to incorporate the preparation into a stainless steel tank, provided with vanes and automatic mechanical agitation, at a stirring speed between 1,000 rpm and 3,000 rpm.
  • the cleaning composition Add to the cleaning composition, the C12-C14 Sodium Lauryl Sulfate surfactant, in a concentration between 10 and 40 percent by weight, add the mentha piperita extract in a concentration of 0.5 to 1 percent in weight, the thickener Sodium chloride food grade in a concentration between 4 to 8 percent by weight, and the aroma aroma lemon, or apple, or cinnamon or others in concentrations between 0.5 to 3 percent by weight, mix and homogenize For a period of 10-20 minutes, finish the manufacturing process by adding demineralized water until one hundred percent concentration by weight is complete, package.

Abstract

The invention relates to a cleaning composition comprising copper and mentha piperita extract, to be used in the cleaning of all types of surfaces, for household and industrial use, said composition containing a surfactant, a high concentration of soluble copper salts as an anti-bacterial agent, mentha piperita as a complementary anti-bacterial agent, a thickening agent, a fragrance and demineralised water completing the preparation. The mixture is carried out in a stainless steel reactor at between 21 and 30°C.

Description

Composición de limpieza concentrada con Cobre y extracto de Mentha Piperita, para la limpieza de todo tipo de superficies de uso domiciliario e industrial  Concentrated cleaning composition with Copper and Mentha Piperita extract, for cleaning all types of household and industrial use surfaces
La presente invención, dice relación, con una composición de limpieza concentrada con cobre y extracto de mentha piperita, un procedimiento para su preparación, su uso y aplicación en la limpieza de todo tipo de superficies, tales como pisos, paredes, mesones de trabajo, pasamanos, superficies de cerámica, baldosas, plásticos, de uso domiciliario e industrial.  The present invention relates to a cleaning composition with copper and mentha piperita extract, a process for its preparation, its use and application in the cleaning of all types of surfaces, such as floors, walls, work tables, handrails, ceramic surfaces, tiles, plastics, for home and industrial use.
Aunque las composiciones de limpieza , se conocen en la técnica, la necesidad de utilizar productos, que cumplan un doble propósito, limpiar y desinfectar a la vez, facilitando la labor diaria, de las personas, se ha incrementado los últimos años, siendo común en los procesos de limpieza de superficies, la utilización de variadas composiciones detergentes y de desinfección por separado, que requieren condiciones ambientales óptimas, para obtener resultados satisfactorios, este objetivo no se cumple, en la mayoría de los casos, debido a la presencia de materia orgánica, y a una alta concentración de microorganismos patógenos que existen en el ambiente, como bacterias, virus, y hongos, que tienen la facultad de adaptarse rápidamente a las estructuras químicas y biológicas de los agentes limpiadores y desinfectantes, generando resistencia bacteriana, esto tiene como consecuencia directa, el aumento creciente y permanente de las dosis de uso de limpiadores y desinfectantes, cuya consecuencia final se puede observar claramente en recintos hospitalarios, en la industria alimenticia, o en recintos de gran flujo de personas, donde la resistencia de bacterias como la Escherichia Coli, Listeria, Speudomonas, entre otros, ha provocado brotes epidémicos de difícil control y eliminación. La composición de limpieza concentrada con cobre y extracto de mentha piperita, propuesta en esta invención, viene a mejorar el problema de la resistencia bacteriana, que se presenta en el uso permanente de desinfectantes y limpiadores, proporcionando en una sola composición concentrada, un agente limpiador, un agente antibacteriano de sales de cobre y extracto de menta piperita, agente complementario en la disminución de la carga bacteriana, esto contribuye en los efectos residuales que presenta la composición de limpieza . Although cleaning compositions are known in the art, the need to use products, which serve a dual purpose, to clean and disinfect at the same time, facilitating the daily work of people, has increased in recent years, being common in surface cleaning processes, the use of various detergent and disinfection compositions separately, which require optimal environmental conditions, to obtain satisfactory results, this objective is not met, in most cases, due to the presence of organic matter , and a high concentration of pathogenic microorganisms that exist in the environment, such as bacteria, viruses, and fungi, which have the power to adapt quickly to the chemical and biological structures of cleaning and disinfectant agents, generating bacterial resistance, this has as a consequence direct, increasing and permanent increase in the doses of use of cleaners and disinfectants, c A final consequence can be clearly observed in hospital enclosures, in the food industry, or in large-flowed areas of people, where the resistance of bacteria such as Escherichia Coli, Listeria, Speudomonas, among others, has caused epidemic outbreaks of difficult control elimination. The cleaning composition concentrated with copper and mentha piperita extract, proposed in this invention, improves the problem of bacterial resistance, which occurs in the permanent use of disinfectants and cleaners, providing in a single concentrated composition, a cleaning agent , an antibacterial agent of copper salts and peppermint extract, complementary agent in the reduction of bacterial load, this contributes to the residual effects of the cleaning composition.
Estudios realizados por la Sociedad Iberoamericana de Información Científica (SIIC) de año 2002, determinaron IN VITRO, que la mentha piperita elimina bacterias como E. coli, S. aureus, Pseudomonas aeruginosa, S. faecalis, Klebsiella pneumoniae, diversos estudios científicos han demostrado además que la mentha piperita tiene efectos antiparasitarios sobre distintos ectoparásitos , como el H. tuberculatus, Musca domestica, Stomoxys calcitrans, Haematobia irritans, Hippobosca equina, Culex quinquefasciatus y pipiens, Aedes aegypti. Studies conducted by the Ibero-American Society for Scientific Information (SIIC) in 2002, determined IN VITRO, that mentha piperita eliminates bacteria such as E. coli, S. aureus, Pseudomonas aeruginosa, S. faecalis, Klebsiella pneumoniae, various scientific studies have shown In addition, mentha piperita has antiparasitic effects on different ectoparasites, such as H. tuberculatus, Musca domestica, Stomoxys calcitrans, Haematobia irritans, Hippobosca equina, Culex quinquefasciatus and pipiens, Aedes aegypti.
Otros estudios realizados por el Department of Biotechnology, Sri Venkateswara University, Tirupathi, India; han determinado que los extractos de mentha piperita, presentan propiedades antifúngicas contra Candida albicans, Aspergillus albus. Other studies conducted by the Department of Biotechnology, Sri Venkateswara University, Tirupathi, India; they have determined that mentha piperita extracts have antifungal properties against Candida albicans, Aspergillus albus.
Descripción resumida de la Invención  Summary Description of the Invention
El objetivo de esta invención, es proporcionar una composición de limpieza concentrada con cobre y extracto de mentha piperita , que permita realizar la limpieza de todo tipo de superficies, como por ejemplo , pisos, paredes, mesones, salas de preparación de alimentos, ayudando a disminuir la presencia de microorganismos patógenos, en recintos altamente contaminados, fábricas de alimentos, recintos hospitalarios, colegios, industrias en general, proporcionando un mejor proceso de limpieza de las superficies tratadas. Al no contener la composición detergente elementos volátiles, permite mantener un efecto residual en el tiempo, lo que aumenta el efecto antibacterial de la composición de limpieza, disminuye además la contaminación ambiental, al reducir las emanaciones de mal olor de los recintos, donde se faenan animales, como mataderos, recintos agropecuarios, veterinarias, entre otros, contribuyendo a mejorar la calidad de vida de las personas. Descripción detallada de la Invención The objective of this invention is to provide a concentrated cleaning composition with copper and mentha piperita extract, which allows cleaning of all types of surfaces, such as floors, walls, inns, food preparation rooms, helping to reduce the presence of pathogenic microorganisms, in highly contaminated enclosures, food factories, hospital enclosures, schools, industries in general, providing a better process of cleaning the treated surfaces. By not containing the detergent composition volatile elements, it allows to maintain a residual effect over time, which increases the antibacterial effect of the cleaning composition, also reduces environmental pollution, by reducing the odor emissions of the enclosures, where they work animals, such as slaughterhouses, agricultural enclosures, veterinarians, among others, contributing to improve the quality of life of people. Detailed description of the invention
La composición de limpieza concentrada con cobre y extracto de mentha piperita, de la presente invención, se caracteriza por contener una sal de cobre en peso de 3 % a 15 %, dada su alta concentración, proporciona a la composición limpieza , un efecto antibacterial, incrementando los efectos residuales de la misma en el tiempo, contiene ademas un 0.5-1 % en peso de extracto de mentha piperita , que potencia los efectos antibacteriales del cobre, actuando como agente complementario en la disminución de microorganismos patógenos, un 10 a 40 % en peso de un surfactante tensoactivo Lauril Sulfato de Sodio de cadena corta con 12 a 14 átomos de Carbono (C12-C14 , SLES ) , qué proporciona un alto grado de limpieza, adecuados niveles de espuma, ampliamente usado en formulaciones de jabones, shampoo, entre otras preparaciones de uso cosmético e industrial, la preparación de limpieza con cobre y extracto de menta , contiene además, un 4 a 8 % en peso de un agente espesante Cloruro de Sodio grado alimenticio,un 0.5 a 3 % en peso , de una fragancia o perfume esencia de limón, menta, manzana, lavanda, u otras , agua desmineralizada cantidad suficiente para un 100 % en peso de componentes.  The cleaning composition concentrated with copper and mentha piperita extract, of the present invention, is characterized by containing a copper salt by weight of 3% to 15%, given its high concentration, provides the cleaning composition with an antibacterial effect, increasing its residual effects over time, it also contains 0.5-1% by weight of mentha piperita extract, which enhances the antibacterial effects of copper, acting as a complementary agent in the reduction of pathogenic microorganisms, 10 to 40% by weight of a surfactant surfactant Sodium Lauryl Sulfate short chain with 12 to 14 Carbon atoms (C12-C14, SLES), which provides a high degree of cleanliness, adequate levels of foam, widely used in soap, shampoo formulations, among other preparations for cosmetic and industrial use, the cleaning preparation with copper and mint extract, also contains 4 to 8% by weight of a thickening agent Chloride of Sodium food grade, 0.5 to 3% by weight, of a fragrance or perfume essence of lemon, mint, apple, lavender, or other, demineralized water sufficient quantity for 100% by weight of components.
Tabla de Composición  Composition Table
INGREDIENTES % P/P INGREDIENTS% P / P
Surfactante Tensoactivo 10 % a 40 %  Surfactant Surfactant 10% to 40%
Lauril Sulfato de Sodio  Sodium Lauryl Sulfate
Sal de Cobre como sulfato 2 % a 15 %  Copper salt as 2% to 15% sulfate
Extracto de Mentha piperita 0.5-5 %  Mentha piperita extract 0.5-5%
Espesante Cloruro de Sodio 4 % a 8 %  Sodium Chloride Thickener 4% to 8%
grado alimenticio  alimentary grade
Fragancia 0.5 % a 3%  Fragrance 0.5% to 3%
Agua desmineralizada Cantidad suficiente para (c.s.p)  Demineralized water Enough quantity for (c.s.p)
completar el 100 % complete 100%
La composición de limpieza con cobre y extracto de mentha piperita, se presenta como una preparación líquida, levemente viscosa, cuyo campo de aplicación, está destinado a la limpieza de todo tipo de superficies, de uso domiciliario e industrial, como por ejemplo la limpieza de cerámicas, baldosas, azulejos, linóleos, en pisos y paredes, en recintos hospitalarios, plantas de procesos, instalaciones de comida rápida, medios de transportes, domicilios particulares, colegios, etc. The cleaning composition with copper and mentha piperita extract, is presented as a liquid preparation, slightly viscous, whose field of application, is intended for cleaning all types of surfaces, for home and industrial use, such as cleaning of ceramics, tiles, tiles, linoleum, in floors and walls, in hospital rooms, process plants, fast food facilities, means of transport, private homes, schools, etc.
La composición de limpieza con cobre y extracto de mentha piperita, debido a su alta concentración de sales de cobre, mejora las características físico- químicas de los limpiadores existentes en el mercado, conocidas en la técnica, y que están relacionadas con el tema, como por ejemplo , las patentes Japonesas C11D1/29, A61K8/00 , la patente Norteamericana US US4024078 ,CllD17/00 en donde el ion cobre, junto a otros iones metálicos como el manganeso, zinc, estaño, plata, se encuentran en bajas concentraciones, como aditivos , para la eliminación de manchas de grasas , concentraciones bajas de cobre en dichas composiciónes , limitan y reducen el efecto antibacterial, frente a elevadas concentraciones de materia orgánica y la resistencia de microrganismos patógenos del medio ambiente. The cleaning composition with copper and mentha piperita extract, due to its high concentration of copper salts, improves the physicochemical characteristics of cleaners existing in the market, known in the art, and which are related to the subject, such as for example, Japanese patents C11D1 / 29, A61K8 / 00, US patent US4024078, CllD17 / 00 where the ion copper, together with other metal ions such as manganese, zinc, tin, silver, are in low concentrations, as additives, for the removal of grease stains, low concentrations of copper in said compositions limit and reduce the antibacterial effect, against high concentrations of organic matter and the resistance of pathogenic microorganisms of the environment.
La actividad inhibitoria del cobre depende de su concentración, de la presencia o no de proteínas ligantes de cobre, como en el caso, de Vibrio alginolyticus, que puede sobrevivir en concentraciones elevadas de cobre , bacterias como Staphylococcus Aureus, muían en bajas concentraciones de biocidas, ampliamente utilizados para desinfectar, en recintos hospitalarios, es por ello que la composición de limpieza concentrada con cobre propuesta en esta patente de invención es potenciada , al contener en su formulación, mentha piperita, cuyos efectos en la reducción e inhibición de microorganismos patógenos han sido estudiados por la comunidad científica internacional. La lucha permanente en recintos de alto flujo de personas, como hospitales, industrias alimenticias, instituciones públicas y privadas, en evitar y disminuir la resistencia de los microorganismos patógenos, en muchas ocasiones resulta infructuosa, generándose brotes epidémicos de difícil control. Los agentes antibacteriales que se utilizan en limpiadores, desinfectantes y antisépticos , en dosis bajas, provocan que las bacterias y virus puedan formar biopelículas, que son agrupaciones de microorganismos recubiertas de polímeros extracelulares que sirven de protección a los microorganismos, lo que les permite sobrevivir y hacerse resistente a los limpiadores y desinfectantes. The inhibitory activity of copper depends on its concentration, on the presence or not of copper binding proteins, as in the case of Vibrio alginolyticus, which can survive in high concentrations of copper, bacteria such as Staphylococcus Aureus, die in low concentrations of biocides , widely used to disinfect, in hospital enclosures, that is why the copper concentrated cleaning composition proposed in this invention patent is enhanced, by containing in its formulation, mentha piperita, whose effects on the reduction and inhibition of pathogenic microorganisms have been studied by the international scientific community. The permanent struggle in high-flow precincts of people, such as hospitals, food industries, public and private institutions, to avoid and reduce the resistance of pathogenic microorganisms, is often unsuccessful, generating epidemic outbreaks of difficult control. Antibacterial agents used in cleansers, disinfectants and antiseptics, in low doses, cause bacteria and viruses to form biofilms, which are clusters of microorganisms coated with extracellular polymers that serve to protect microorganisms, allowing them to survive and Become resistant to cleaners and disinfectants.
La Organización mundial de la Salud (OMS), la Agencia de Protección ambiental de Estado Unidos, que en estudios en conjunto con la Universidad Médica de Carolina del Sur, de Estados Unidos, que el año 2011, determinó mediante estudios clínicos que el Cobre elimina sobre el 90 % de agentes microbianos, el cobre además tiene la capacidad de inhibir el crecimiento microorganismos patógenos en forma rápida a temperaturas de refrigeración (4°C) y ambientales (20°C), en un periodo de tiempo de cuatro horas.  The World Health Organization (WHO), the United States Environmental Protection Agency, which in studies in conjunction with the Medical University of South Carolina, United States, which in 2011, determined through clinical studies that Copper eliminates over 90% of microbial agents, copper also has the ability to inhibit the growth of pathogenic microorganisms rapidly at refrigeration (4 ° C) and environmental (20 ° C) temperatures, over a period of four hours.
Factores físicos-químicos, como la concentración, el Ph, la temperatura, el tiempo de exposición y acción, las fuentes biológicas, son elementos que determinan, la eficacia de los limpiadores y desinfectantes en la eliminación de los microorganismos patógenos de las superficies que se desean tratar, también generan sustancias volátiles tóxicas para las personas y los animales , provocando cuadros respiratorios que perjudican la recuperación post operatorias (Sander y col., 1995; Gerrits y col.1991), su uso prolongado daña las mucosas y lesiona las vías respiratorias, los componentes volátiles además disminuyen el efecto en el tiempo de los procesos de limpieza y desinfección, lo que obliga a realizar rotaciones permanentes de desinfectantes, para evitar la resistencia bacteriana. Physical-chemical factors, such as concentration, Ph, temperature, exposure time and action, biological sources, are determining elements, the effectiveness of cleaners and disinfectants in the elimination of pathogenic microorganisms from the surfaces that are They want to treat, they also generate volatile substances toxic to people and animals, causing respiratory conditions that impair post-operative recovery (Sander et al., 1995; Gerrits et al. 1991), their prolonged use damages the mucous membranes and injures the respiratory tract , the volatile components also diminish the effect in time of the cleaning and disinfection processes, forcing permanent rotations of disinfectants, to avoid bacterial resistance.
El cobre por su capacidad de atacar la pared celular, y de penetrar al interior de las células de los microorganismos, evita el transporte de los nutrientes básicos, provocando la muerte celular y por lo tanto de los microorganismos, logrando además una menor adaptación y resistencia en el tiempo, por lo que es considerado un elemento importante para el control de los microorganismos patógenos, reconociendo al Cobre como un metal bactericida. La composición de limpieza concentrada con cobre y extracto de mentha piperita, propuesta en esta patente de invención, no contiene solventes volátiles como el Alcohol Etílico o Isopropílico, lo que permite mantener un efecto residual del cobre en el tiempo, aumentando los periodos de latencia del proceso de limpieza, en donde los limpiadores tradicionales no actúan, debido a las bajas concentraciones de elementos antibacteriales, además la composición limpiadora concentrada, presenta un elevado nivel de detergencia, lo que permite un alto rendimiento a un menor costo. Copper, due to its ability to attack the cell wall, and to penetrate inside the cells of microorganisms, prevents the transport of basic nutrients, causing cell death and therefore of microorganisms, also achieving a lower adaptation and resistance In time, it is considered an important element for the control of pathogenic microorganisms, recognizing Copper as a bactericidal metal. The cleaning composition concentrated with copper and mentha piperita extract, proposed in this invention patent, does not contain volatile solvents such as Ethyl or Isopropyl Alcohol, which allows maintaining a residual effect of copper over time, increasing the latency periods of the cleaning process, where traditional cleaners do not act, due to the low concentrations of antibacterial elements, in addition to the concentrated cleaning composition, has a high level of detergency, which allows high performance at a lower cost.
Como ejemplo de la acción antibacteriana de la composición de limpieza concentrada con cobre y mentha piperita , se realizaron pruebas in vitro, de acuerdo a la norma Chilena NCh 2659 Of2002, para recuentos aeróbicos mesófilos, en la Universidad de Santiago de Chile, departamento de Microbiología, año 2012, con la composición limpiadora con cobre señalada en esta patente de invención, y se obtuvieron resultados positivos de inhibición del crecimiento bacteriano, en concentraciones de dilución de la composición entre el 20 % y el 95 % en peso, de acuerdo a las siguientes tablas.  As an example of the antibacterial action of the cleaning composition concentrated with copper and mentha piperita, in vitro tests were carried out, according to Chilean Standard NCh 2659 Of2002, for mesophilic aerobic counts, at the University of Santiago de Chile, Department of Microbiology , year 2012, with the copper cleaning composition indicated in this invention patent, and positive results of bacterial growth inhibition were obtained, in dilution concentrations of the composition between 20% and 95% by weight, according to the following tables.
TABLA N°2 CEPA ESCHERICHLA COLI TABLE N ° 2 CEPA ESCHERICHLA COLI
Figure imgf000007_0001
Figure imgf000007_0001
UFC: Unidad formadora de colonias 5 000024 UFC: Colony Forming Unit 5 000024
-7--7-
TABLA N°3: CEPA STAPHYLOCOCCUS AUREUS TABLE N ° 3: STAPHYLOCOCCUS AUREUS CEPA
Figure imgf000008_0001
Figure imgf000008_0001
Concentraciones de la composición de limpieza con cobre, entre el 20 % y el 95 % en peso, inhibieron el crecimiento bacteriano de Escherichia Coli y Staphylococcus Aureus en rango promedio menores a 1 UFC/ml, al estar en contacto con la composición limpiadora con cobre por un periodo de tiempo de 5 a 10 minutos, en comparación con el blanco, sin la composición limpiadora con cobre, que presento crecimientos bacterianos de 1,2 x 106 UFC/ml y 3,6 x 107 UFC/ml respectivamente. Concentrations of the copper cleaning composition, between 20% and 95% by weight, inhibited the bacterial growth of Escherichia Coli and Staphylococcus Aureus in average range less than 1 CFU / ml, by being in contact with the copper cleaning composition for a period of 5 to 10 minutes, compared to the blank, without the copper cleaning composition, which presented bacterial growths of 1.2 x 10 6 CFU / ml and 3.6 x 10 7 CFU / ml respectively.
La presente invención está relacionada además con un procedimiento de fabricación de dicha composición, que se caracteriza principalmente por disolver las sales de cobre en una solución acuosa, cuya concentración se encuentra entre los veinte mil partes por millón y las trescientas mil partes por millón en peso, proceder a incorporar la preparación a un estanque de acero inoxidable, provisto con paletas y agitación mecánica automática, a una velocidad de agitación entre los 1.000 rpm y los 3.000 r.pm.  The present invention is further related to a method of manufacturing said composition, which is characterized primarily by dissolving copper salts in an aqueous solution, the concentration of which is between twenty thousand parts per million and three hundred thousand parts per million by weight , proceed to incorporate the preparation into a stainless steel tank, provided with vanes and automatic mechanical agitation, at a stirring speed between 1,000 rpm and 3,000 rpm.
Agregar a la composición de limpieza, el agente tensoactivo Lauril Sulfato de Sodio de cadena C12-C14, en una concentración entre 10 y 40 por ciento en peso, agregar el extracto de mentha piperita en una concentración de 0,5 a 1 por ciento en peso, el agente espesante Cloruro de Sodio grado alimenticio en una concentración entre 4 a 8 por ciento en peso, y la f agancia aroma limón, o manzana, o canela u otras en concentraciones entre 0.5 a 3 por ciento en peso, mezclar y homogenizar por un periodo de 10-20 minutos , finalizar el proceso de fabricación agregando agua desmineralizada hasta completar el cien por ciento de concentración en peso, envasar.  Add to the cleaning composition, the C12-C14 Sodium Lauryl Sulfate surfactant, in a concentration between 10 and 40 percent by weight, add the mentha piperita extract in a concentration of 0.5 to 1 percent in weight, the thickener Sodium chloride food grade in a concentration between 4 to 8 percent by weight, and the aroma aroma lemon, or apple, or cinnamon or others in concentrations between 0.5 to 3 percent by weight, mix and homogenize For a period of 10-20 minutes, finish the manufacturing process by adding demineralized water until one hundred percent concentration by weight is complete, package.

Claims

PLIEGO DE REIVINDICACIONES CLAIM OF CLAIMS
1.- Una composición de limpieza concentrada con cobre y extracto de mentha piperita, biodegradable, que no contiene agentes volátiles, para la limpieza de todo tipo de superficies, tanto de uso domiciliario como en la industria en general, que ayuda a disminuir los microorganismos patógenos, Gram positivos y Gram negativos, presentes en el medio ambiente ,evitando la resistencia bacteriana, presentado un gran efecto residual del limpiador en el tiempo, CARACTERIZADA por que contiene, un surfactante tensoactivo biodegradable, sales de Cobre, un agente complementario antibacterial, extracto de menta, un agente espesante Cloruro de Sodio, de grado alimenticio, una fragancia, y el saldo es agua desmineralizada, la preparación de la composición es realizada entre 21 - 30 0 Celsius. 1.- A cleaning composition concentrated with copper and extract of mentha piperita, biodegradable, which does not contain volatile agents, for cleaning all types of surfaces, both for home use and in the industry in general, which helps reduce microorganisms pathogens, Gram positive and Gram negative, present in the environment, avoiding bacterial resistance, presented a great residual effect of the cleaner over time, CHARACTERIZED because it contains, a biodegradable surfactant surfactant, Copper salts, a complementary antibacterial agent, extract peppermint, a thickening agent sodium chloride, food grade, a fragrance, and the balance is demineralized water, the preparation of the composition is held at 21 - 30 0 Celsius.
2.- La composición de limpieza concentrada de acuerdo con la Reivindicación 1, CARACTERIZADA por que el agente surfactante tensoactivo Lauril Sulfato de Sodio de cadena C12-C14 es agregado en una concentración entre 10 a 40 % en peso total de la composición. 2. The concentrated cleaning composition according to Claim 1, CHARACTERIZED in that the surfactant surfactant Sodium Lauryl Sulfate C12-C14 chain is added in a concentration between 10 to 40% by total weight of the composition.
3.- La composición de limpieza concentrada de acuerdo con la Reivindicación 1, CARACTERIZADA por que el agente antibacterial es una sal de Cobre, grado técnico que es agregado en una concentración entre 2 a 15 % en peso total de la composición. 3. The concentrated cleaning composition according to Claim 1, CHARACTERIZED in that the antibacterial agent is a Copper salt, technical grade that is added in a concentration between 2 to 15% by total weight of the composition.
4.- La composición de limpieza concentrada de acuerdo con la Reivindicación 1, CARACTERIZADA por que el agente complementario antibacterial es un extracto de mentha piperita, es agregado en una concentración entre 05- a 1 % en peso total de la composición. 4. The concentrated cleaning composition according to Claim 1, CHARACTERIZED in that the antibacterial complementary agent is an extract of mentha piperite, is added in a concentration between 05- to 1% by total weight of the composition.
5.- La composición de limpieza concentrada de acuerdo con la Reivindicación 1, CARACTERIZADA por que el agente espesante es Cloruro de Sodio grado alimenticio al 99 % es agregado en una concentración entre 4 a 8 % en peso total de la composición. 5. The concentrated cleaning composition according to Claim 1, CHARACTERIZED in that the thickening agent is 99% food grade Sodium Chloride is added in a concentration between 4 to 8% by total weight of the composition.
6. -La composición de limpieza concentrada de acuerdo con la Reivindicación 1, CARACTERIZADA por que el agente de fragancia es una esencia aroma a limón, o menta, o lavanda, o manzana, o canela es agregado en una concentración entre 0.5 a 3 % en peso total de la composición. 6. The concentrated cleaning composition according to Claim 1, CHARACTERIZED in that the fragrance agent is a scent of lemon, mint, or lavender, or apple, or cinnamon is added in a concentration between 0.5 to 3% in total weight of the composition.
7. -La composición de limpieza concentrada de acuerdo con la Reivindicación 1, CARACTERIZADA por que el resto de la composición es agua desmineralizada, hasta completar el 100 % en peso. 7. The concentrated cleaning composition according to Claim 1, CHARACTERIZED in that the rest of the composition is demineralized water, until 100% by weight is completed.
8. -Procedimiento de preparación de la composición de la reivindicación 1, CARACTERIZADA por que se mezclan: 8. Procedure for preparing the composition of claim 1, CHARACTERIZED by mixing:
a) de 2 a 15 % en peso de la sal de Cobre a) 2 to 15% by weight of Copper salt
b) de 10 a 40 % en peso de surfactante tensoactivo Lauril Sulfato de Sodio c) de 0.5 a 1 % en peso de un extracto de mentha piperita b) 10 to 40% by weight of surfactant surfactant Sodium Lauryl Sulfate c) 0.5 to 1% by weight of a extract of mentha piperita
d) de 4 a 8 % en peso de un agente espesante Cloruro de Sodio grado alimenticio e) de 0.5 a 3 % en peso de f agancia esencia de limón, o lavanda, o manzana, o menta, o canela d) from 4 to 8% by weight of a thickener Sodium chloride food grade e) from 0.5 to 3% by weight of fragrance essence of lemon, or lavender, or apple, or mint, or cinnamon
f) el resto de la composición es agua desmineralizada hasta completar el 100 % de la composición en peso. f) the rest of the composition is demineralized water until 100% of the composition is completed by weight.
9.- Procedimiento de preparación de la composición de acuerdo a la reivindicación 8, CARACTERIZADA por que se disuelve la sal de Cobre en agua desmineralizada, en una concentración entre 2 a 15 % en peso, a una temperatura entre 2 ° y 30 0 Celsius, se agrega a un reactor de acero inoxidable, donde se mezcla con el surfactante tensoactivo Lauril Sulfato de Sodio en concentración entre 10 a 40 % en peso , agregando el agente espesante Cloruro de Sodio grado alimenticio en concentración entre 4 a 8 % por ciento, en peso, junto con el extracto de mentha piperita a una concentración de 0.5 a l % en peso, se mezcla por un periodo de 15 minutos, se agrega la fragancia aroma limón, o menta, o manzana o canela o lavanda, según corresponda en una concentración entre 0.5 - 3 % en peso, se mezcla nuevamente, por un periodo de 10 minutos y se finaliza con agua desmineralizada hasta completar el 100 % de la composición en peso. 9. Method of preparing the composition according to claim 8, CHARACTERIZED by dissolving the copper salt in demineralized water, in a concentration between 2 to 15% by weight, at a temperature between 2 ° and 30 0 Celsius , is added to a stainless steel reactor, where it is mixed with the surfactant surfactant Sodium Lauryl Sulfate in concentration between 10 to 40% by weight, adding the thickener Sodium chloride food grade in concentration between 4 to 8% percent, by weight, together with the extract of mentha piperita at a concentration of 0.5% by weight, it is mixed for a period of 15 minutes, the fragrance is added lemon, or mint, or apple or cinnamon or lavender, as appropriate in a concentration between 0.5 - 3% by weight, mixed again, for a period of 10 minutes and finished with demineralized water to complete 100% of the composition by weight.
10.- El uso de la composición de acuerdo con cualquiera de las reivindicaciones 1 a 10, CARACTERIZADA porque es una composición de limpieza concentrada con cobre y extracto de mentha piperita, utilizada en la limpieza y disminución de microorganismos patógenos de todo tipo de superficies duras, como por ejemplo pisos, paredes, baldosas, azulejos, cerámicas, linóleos, vidrios, para uso domiciliario en cocinas, baños, patios, e industrial, como por ejemplo, recintos hospitalarios, fábricas de alimentos, colegios, medios de transporte, recintos de comida rápida, centros de atención de público, plantas de faenamiento de animales, frigoríficos, empresas agropecuarias productoras de aves de corral, planteles de cerdos, vacunos, centros de cultivos de salmónidos, centros veterinarios, entre otros. 10. The use of the composition according to any of claims 1 to 10, CHARACTERIZED because it is a cleaning composition concentrated with copper and mentha piperita extract, used in the cleaning and reduction of pathogenic microorganisms of all types of hard surfaces , such as floors, walls, tiles, tiles, ceramics, linoleum, glass, for home use in kitchens, bathrooms, patios, and industrial, such as hospital enclosures, food factories, schools, means of transport, enclosures fast food, public attention centers, animal slaughter plants, refrigerators, agricultural companies producing poultry, pig farms, cattle, salmon farming centers, veterinary centers, among others.
PCT/CL2015/000024 2014-04-25 2015-04-17 Concentrated cleaning composition comprising copper and mentha piperita extract,for cleaning all types of surfaces for household and industrial use WO2015161392A1 (en)

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