WO2015131056A3 - Waveguide-based detection system with scanning light source - Google Patents

Waveguide-based detection system with scanning light source Download PDF

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Publication number
WO2015131056A3
WO2015131056A3 PCT/US2015/018032 US2015018032W WO2015131056A3 WO 2015131056 A3 WO2015131056 A3 WO 2015131056A3 US 2015018032 W US2015018032 W US 2015018032W WO 2015131056 A3 WO2015131056 A3 WO 2015131056A3
Authority
WO
WIPO (PCT)
Prior art keywords
light source
substrate
scanning light
waveguides
waveguide
Prior art date
Application number
PCT/US2015/018032
Other languages
French (fr)
Other versions
WO2015131056A2 (en
Inventor
Reuven Duer
Original Assignee
Indx Lifecare, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/194,437 external-priority patent/US9423397B2/en
Application filed by Indx Lifecare, Inc. filed Critical Indx Lifecare, Inc.
Publication of WO2015131056A2 publication Critical patent/WO2015131056A2/en
Publication of WO2015131056A3 publication Critical patent/WO2015131056A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres

Abstract

The invention provides methods and devices for generating optical pulses in one or more waveguides using a spatially scanning light source. A detection system, methods of use thereof and kits for detecting a biologically active analyte molecule are also provided. The system includes a scanning light source, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, a detector that is coupled to and in optical communication with the substrate, and means for spatially translating a light beam emitted from said scanning light source such that the light beam is coupled to and in optical communication with the waveguides of the substrate at some point along its scanning path. The use of a scanning light source allows the coupling of light into the waveguides of the substrate in a simple and cost-effective manner.
PCT/US2015/018032 2014-02-28 2015-02-27 Waveguide-based detection system with scanning light source WO2015131056A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/194,437 US9423397B2 (en) 2006-03-10 2014-02-28 Waveguide-based detection system with scanning light source
US14/194,437 2014-02-28

Publications (2)

Publication Number Publication Date
WO2015131056A2 WO2015131056A2 (en) 2015-09-03
WO2015131056A3 true WO2015131056A3 (en) 2015-11-19

Family

ID=54009791

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/018032 WO2015131056A2 (en) 2014-02-28 2015-02-27 Waveguide-based detection system with scanning light source

Country Status (1)

Country Link
WO (1) WO2015131056A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107003234B (en) * 2014-07-29 2020-01-21 Ldip有限责任公司 Partially packaged waveguide-based sensing chip, system and method of use
CN108845146A (en) * 2018-06-21 2018-11-20 微粒云科技（北京）有限公司 A kind of biochip for myocardium five marker detections, detection method
CN108828231A (en) * 2018-06-21 2018-11-16 微粒云科技（北京）有限公司 A kind of cardio-pulmonary function marker magnetic particle microflow controlled biochip, detection method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5671303A (en) * 1996-04-17 1997-09-23 Motorola, Inc. Molecular detection apparatus and method using optical waveguide detection
US6078705A (en) * 1995-05-12 2000-06-20 Novartis Ag Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence
JP2010160087A (en) * 2009-01-09 2010-07-22 Nitto Denko Corp Optical waveguide type chemical sensor
US20130215425A9 (en) * 2006-03-10 2013-08-22 Reuven Duer Waveguide-based detection system with scanning light source

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6078705A (en) * 1995-05-12 2000-06-20 Novartis Ag Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence
US5671303A (en) * 1996-04-17 1997-09-23 Motorola, Inc. Molecular detection apparatus and method using optical waveguide detection
US20130215425A9 (en) * 2006-03-10 2013-08-22 Reuven Duer Waveguide-based detection system with scanning light source
JP2010160087A (en) * 2009-01-09 2010-07-22 Nitto Denko Corp Optical waveguide type chemical sensor

Also Published As

Publication number Publication date
WO2015131056A2 (en) 2015-09-03

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