WO2015097190A3 - Device and method for characterisation of biological samples - Google Patents

Device and method for characterisation of biological samples Download PDF

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Publication number
WO2015097190A3
WO2015097190A3 PCT/EP2014/079080 EP2014079080W WO2015097190A3 WO 2015097190 A3 WO2015097190 A3 WO 2015097190A3 EP 2014079080 W EP2014079080 W EP 2014079080W WO 2015097190 A3 WO2015097190 A3 WO 2015097190A3
Authority
WO
WIPO (PCT)
Prior art keywords
reflector
sample
skin
extracted
incident radiation
Prior art date
Application number
PCT/EP2014/079080
Other languages
French (fr)
Other versions
WO2015097190A2 (en
Inventor
Dewan Fazlul Hoque Chowdhury
Original Assignee
Ndm Technologies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ndm Technologies Limited filed Critical Ndm Technologies Limited
Publication of WO2015097190A2 publication Critical patent/WO2015097190A2/en
Publication of WO2015097190A3 publication Critical patent/WO2015097190A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B2010/0009—Testing for drug or alcohol abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs

Abstract

An apparatus for measuring the concentration of an analyte in a sample extracted from the skin (10) of a patient comprises a collection chamber (3) adjacent to the skin; a radiation source (7) configured to irradiate the sample in the collection chamber (3); a reflector (4) configured to reflect incident radiation back through the sample; and a sensor (11) configured to measure the radiation emitted from the sample. The reflector (4) may shield the skin (10) from the incident radiation and have a convoluted or perforated shape to permit sufficient diffusion of the extracted analyte to all parts of the surface of the reflector from its edges. The reflector (4) may be a reflective surface of reverse iontophoresis electrodes (9) used to extract the sample from the skin. In a further apparatus the reflector (4) is implanted beneath an outer layer of the skin (10) so that instead of being extracted, the sample can be measured in vivo. An implanted reflector (4) may be formed from an assemblage of reflective particles. A mask (5) may be provided to prevent the incident radiation bypassing the reflector (4).
PCT/EP2014/079080 2013-12-23 2014-12-22 Device and method for characterisation of biological samples WO2015097190A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1322953.9A GB2521627A (en) 2013-12-23 2013-12-23 Device and method for characterisation of biological samples
GB1322953.9 2013-12-23

Publications (2)

Publication Number Publication Date
WO2015097190A2 WO2015097190A2 (en) 2015-07-02
WO2015097190A3 true WO2015097190A3 (en) 2016-05-26

Family

ID=50114708

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2014/079080 WO2015097190A2 (en) 2013-12-23 2014-12-22 Device and method for characterisation of biological samples

Country Status (2)

Country Link
GB (2) GB2531956A (en)
WO (1) WO2015097190A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2774983B2 (en) 2019-01-22 2021-06-10 Univ Sevilla PORTABLE DEVICE AND METHOD FOR NON-INVASIVE ESTIMATION OF GLUCOSE LEVEL IN BLOOD

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022927A1 (en) * 1994-02-23 1995-08-31 Peyman Gholam A Diagnostic system and method using an implanted reflective device
EP1129353A1 (en) * 1999-09-10 2001-09-05 Beckman Coulter, Inc. Minimally invasive methods for measuring analytes in vivo
DE10212140A1 (en) * 2002-03-19 2003-10-09 Henry Arthur Muglia Blood sugar sensor and measuring method for determining the blood sugar value
US20030225322A1 (en) * 2001-11-22 2003-12-04 Kenichi Uchiyama Optical waveguide sensor, device, system and method for glucose measurement
US20040012788A1 (en) * 2002-06-19 2004-01-22 Omron Corporation Method for measuring concentration of component contained in bodily fluid and apparatus for measuring concentration of component contained in bodily fluid
JP2004159994A (en) * 2002-11-14 2004-06-10 Toshiba Corp Apparatus and measuring method for reverse iontophoresis
WO2004085995A2 (en) * 2003-03-24 2004-10-07 Rosedale Medical Inc. Analyte concentration detection devices and methods
US20060198762A1 (en) * 2005-03-04 2006-09-07 Ikuo Uematsu Optical glucose sensor chip
US7236812B1 (en) * 2003-09-02 2007-06-26 Biotex, Inc. System, device and method for determining the concentration of an analyte
WO2011084607A1 (en) * 2009-12-17 2011-07-14 Bayer Healthcare Llc Transdermal systems, devices, and methods for biological analysis
US20120188640A1 (en) * 2009-07-20 2012-07-26 Tufts University/Trustees Of Tufts College All-protein implantable, resorbable reflectors
US20120265038A1 (en) * 2011-04-12 2012-10-18 Panasonic Corporation Method for measuring a concentration of a biogenic substance contained in a living body

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4645340A (en) * 1983-06-01 1987-02-24 Boston University Optically reflective sphere for efficient collection of Raman scattered light
US6438397B1 (en) * 1999-10-28 2002-08-20 Gerald G. Bosquet Method and apparatus for analyte detection using intradermally implanted skin port
DE10011284B4 (en) * 2000-03-08 2007-06-28 Disetronic Licensing Ag Apparatus for in vivo measurement of the concentration of an ingredient of a body fluid
EP1406537B1 (en) * 2001-06-12 2011-01-12 Pelikan Technologies Inc. Integrated blood sampling analysis system with multi-use sampling module
DE102006020720A1 (en) * 2006-05-04 2007-11-08 Robert Bosch Gmbh Interferometric measuring device for optical measurement on skin structures
US7603151B2 (en) * 2006-08-22 2009-10-13 Bayer Healthcare Llc Non-invasive methods of using spectral information in determining analyte concentrations
EP2097508A4 (en) * 2006-12-07 2011-10-26 Univ Ohio State Res Found A system for in vivo biosensing based on the optical response of electronic polymers

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022927A1 (en) * 1994-02-23 1995-08-31 Peyman Gholam A Diagnostic system and method using an implanted reflective device
EP1129353A1 (en) * 1999-09-10 2001-09-05 Beckman Coulter, Inc. Minimally invasive methods for measuring analytes in vivo
US20030225322A1 (en) * 2001-11-22 2003-12-04 Kenichi Uchiyama Optical waveguide sensor, device, system and method for glucose measurement
DE10212140A1 (en) * 2002-03-19 2003-10-09 Henry Arthur Muglia Blood sugar sensor and measuring method for determining the blood sugar value
US20040012788A1 (en) * 2002-06-19 2004-01-22 Omron Corporation Method for measuring concentration of component contained in bodily fluid and apparatus for measuring concentration of component contained in bodily fluid
JP2004159994A (en) * 2002-11-14 2004-06-10 Toshiba Corp Apparatus and measuring method for reverse iontophoresis
WO2004085995A2 (en) * 2003-03-24 2004-10-07 Rosedale Medical Inc. Analyte concentration detection devices and methods
US7236812B1 (en) * 2003-09-02 2007-06-26 Biotex, Inc. System, device and method for determining the concentration of an analyte
US20060198762A1 (en) * 2005-03-04 2006-09-07 Ikuo Uematsu Optical glucose sensor chip
US20120188640A1 (en) * 2009-07-20 2012-07-26 Tufts University/Trustees Of Tufts College All-protein implantable, resorbable reflectors
WO2011084607A1 (en) * 2009-12-17 2011-07-14 Bayer Healthcare Llc Transdermal systems, devices, and methods for biological analysis
US20120265038A1 (en) * 2011-04-12 2012-10-18 Panasonic Corporation Method for measuring a concentration of a biogenic substance contained in a living body

Also Published As

Publication number Publication date
GB2521627A (en) 2015-07-01
WO2015097190A2 (en) 2015-07-02
GB201322953D0 (en) 2014-02-12
GB2531956A (en) 2016-05-04
GB201522844D0 (en) 2016-02-03

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