WO2014193237A3 - C diff protease - Google Patents
C diff protease Download PDFInfo
- Publication number
- WO2014193237A3 WO2014193237A3 PCT/NL2014/050349 NL2014050349W WO2014193237A3 WO 2014193237 A3 WO2014193237 A3 WO 2014193237A3 NL 2014050349 W NL2014050349 W NL 2014050349W WO 2014193237 A3 WO2014193237 A3 WO 2014193237A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protease
- diff
- peptide
- invention further
- clostridium difficile
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
Abstract
The invention relates to a peptide comprising the amino acid sequence A/P- A/P-V/P/I/C/T-P as a substrate for the protease CD2830 of Clostridium difficile. The invention further relates to kit or device comprising the peptide for determining the presence of Clostridium difficile in a sample and for identifying an agent that is capable of modulating protease activity of CD2830. The invention further relates to a composition, preferably a pharmaceutical composition, comprising an inhibitor of the protease activity of CD2830.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13169930 | 2013-05-30 | ||
EP13169930.8 | 2013-05-30 | ||
EP13197876.9 | 2013-12-17 | ||
EP13197876 | 2013-12-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014193237A2 WO2014193237A2 (en) | 2014-12-04 |
WO2014193237A3 true WO2014193237A3 (en) | 2015-03-19 |
Family
ID=50928203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL2014/050349 WO2014193237A2 (en) | 2013-05-30 | 2014-05-30 | C diff protease |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2014193237A2 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060121544A1 (en) * | 1997-09-15 | 2006-06-08 | Annegret Boge | Molecular modification assays |
WO2009010765A2 (en) * | 2007-07-18 | 2009-01-22 | Novacta Biosystems Limited | Lantibiotic-based compounds having antimicrobial activity |
US20100291100A1 (en) * | 2009-03-27 | 2010-11-18 | Gojo Industries, Inc. | Compositions And Methods For Screening And Using Compounds Antagonizing Spore-Surface Interactions |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69737977T2 (en) | 1997-05-01 | 2008-04-17 | Minnesota Mining And Manufacturing Company, St. Paul | FLUOROGENE PROTEASE SUBSTRATES BASED ON COLOR DIMERIZATION |
EP1354201A2 (en) | 2000-02-11 | 2003-10-22 | Cellomics, Inc. | Peptide biosensors for anthrax protease |
-
2014
- 2014-05-30 WO PCT/NL2014/050349 patent/WO2014193237A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060121544A1 (en) * | 1997-09-15 | 2006-06-08 | Annegret Boge | Molecular modification assays |
WO2009010765A2 (en) * | 2007-07-18 | 2009-01-22 | Novacta Biosystems Limited | Lantibiotic-based compounds having antimicrobial activity |
US20100291100A1 (en) * | 2009-03-27 | 2010-11-18 | Gojo Industries, Inc. | Compositions And Methods For Screening And Using Compounds Antagonizing Spore-Surface Interactions |
Non-Patent Citations (2)
Title |
---|
JACQUOT ET AL: "High affinity Grb2-SH3 domain ligand incorporating C<b>eta-substituted prolines in a Sos-derived decapeptide", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 15, no. 3, 19 January 2007 (2007-01-19), pages 1439 - 1447, XP005823084, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2006.11.002 * |
M. VIDAL ET AL: "Design of Peptoid Analogue Dimers and Measure of Their Affinity for Grb2 SH3 Domains +", BIOCHEMISTRY, vol. 43, no. 23, 1 June 2004 (2004-06-01), pages 7336 - 7344, XP055087222, ISSN: 0006-2960, DOI: 10.1021/bi030252n * |
Also Published As
Publication number | Publication date |
---|---|
WO2014193237A2 (en) | 2014-12-04 |
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