WO2014162008A2 - Novel biomarker signature and uses thereof - Google Patents
Novel biomarker signature and uses thereof Download PDFInfo
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- WO2014162008A2 WO2014162008A2 PCT/EP2014/056879 EP2014056879W WO2014162008A2 WO 2014162008 A2 WO2014162008 A2 WO 2014162008A2 EP 2014056879 W EP2014056879 W EP 2014056879W WO 2014162008 A2 WO2014162008 A2 WO 2014162008A2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Definitions
- the present invention relates to novel biomarkers, and signatures comprising the same, for identifying individuals with Hodgkin's lymphoma who are responsive or resistant to treatment with chemotherapeutic agents.
- HL Hodgkin's lymphoma
- the present invention seeks to provide novel biomarkers for use in predicting the responsiveness of a patient with Hodgkin's lymphoma to chemotherapeutic drug treatment.
- the invention provides methods of gene expression analysis in which a novel biomarker 'signature' is obtained to predict the responsiveness of a Hodgkin's lymphoma patient to chemotherapy, wherein the signature corresponds to quantitative information about the amount of a plurality of proteins (or mRNA encoding the same) which have been identified as characteristic of the responsiveness of said patient.
- a first aspect of the invention provides an in vitro method for determining the responsiveness of an individual with Hodgkin's lymphoma to chemotherapeutic drug treatment, the method comprising the steps of:
- Table B lists eighty-six biomarkers previously known or suggested in the art as being of potential diagnostic value in differentiating chemotherapy-responsive from chemotherapy-resistant Hodgkin's lymphoma patients (see ref [34], in particular Table S5 of supplementary appendix therein; the disclosures of which are incorporated herein by reference).
- a positive log-fold change indicates increased expression in chemotherapy-responsive versus chemotherapy-resistant Hodgkin's lymphoma patients
- a negative log-fold change indicates increased expression in chemotherapy-resistant versus chemotherapy-responsive Hodgkin's lymphoma patients.
- the individual being tested is typically a human. However, it will be appreciated that the methods may also be used for the diagnosis of any domestic or farm mammal (such as a horse, pig, cow, sheep, dog or cat).
- any domestic or farm mammal such as a horse, pig, cow, sheep, dog or cat.
- chemotherapeutic drug treatment we include any of the chemotherapeutic drug regimes commonly used clinically in the treatment of Hodgkin's lymphoma.
- ABVD chemotherapy contains the drugs adriamycin (doxorubicin), bleomycin, vinblastine and dacarbazine.
- doxorubicin doxorubicin
- bleomycin bleomycin
- vinblastine bleomycin
- dacarbazine dacarbazine
- advanced stage Hodgkin's lymphoma some people have ABVD for up to 8 cycles.
- chemotherapeutic drug combinations include:
- responsiveness in the context of chemotherapeutic drug treatment of an individual with Hodgkin's lymphoma we include the therapeutic effectiveness of the treatment with respect to Hodgkin's lymphoma.
- responsiveness includes the ability of chemotherapeutic drug treatment to reduce and most preferably prevent a clinically significant deficit in the activity, function and response of the individual with Hodgkin's lymphoma.
- the measure of responsiveness may encompass the effect of the chemotherapeutic drug treatment on one or more of the following:
- Step (a) of the methods of the invention comprises providing a protein or mRNA sample from the individual to be tested.
- the sample is a lymph node tumour biopsy sample (which may have been excised from the individual previously, for example at the time of diagnosis).
- the sample may be a blood or serum sample. It will be appreciated by persons skilled in the art that the samples may be fresh-frozen or formalin-fixed.
- step (b) comprises measuring the presence and/or amount in the sample of at least three proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table A, and/or mRNA encoding the same.
- step (b) may comprise measuring the presence and/or amount in the sample of at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table A, and/or mRNA encoding the same
- the proteins and/or mRNA encoding the same measured in step (b) are selected from one of the following sub-groups defined in Table A:
- step (b) may comprise measuring the presence and/or amount in the sample of biomarker nos. 1 to 10 in Table A (i.e. the first ten biomarkers listed in Table A) and/or mRNA encoding the same
- step (b) comprises measuring the presence and/or amount in the sample of at least one protein, and/or mRNA encoding the same, selected from the group consisting of:
- Zinc finger protein 644 (a) Zinc finger protein 644 (ZNF644) ;
- DC-STAMP domain containing 2 DCST2
- (b) may comprise measuring the presence and/or amount in the sample of all of biomarkers 'a' to ⁇ ' above, and/or mRNA encoding the same (see Table C).
- Table C lists all of the biomarkers identified herein as being differentially expressed (i.e. having an adjusted 'p'-value ['q'-value] of less than 0.05 in patients; see Example A) in all chemotherapy-responsive versus chemotherapy-resistant Hodgkin's lymphoma patients (see Example A below).
- biomarkers 'a' to ⁇ ' above are measured at the mRNA level using the probe sets ("Probe ID's") identified in Table A (from the Affymetrix GeneChip Human Genome U133 Plus 2.0 array, from Affymetrix Inc, Santa Clara, USA).
- probe sets (“Probe ID's") identified in Table A (from the Affymetrix GeneChip Human Genome U133 Plus 2.0 array, from Affymetrix Inc, Santa Clara, USA).
- mRNA levels for heat shock 70kDa protein 5 may be determined using Affymetrix probe set 21 1936 at.
- step (b) comprises measuring the presence and/or amount in the sample of mRNA encoding the proteins selected from the group identified in Table A.
- measuring the presence and/or amount in the sample of the mRNA may be performed using binding agents capable of binding to the said mRNA, for example using oligonucleotides with a nucleotide sequence complementary to the target mRNA in a hybridisation assay.
- step (b) comprises measuring the presence and/or amount in the sample of the proteins selected from the group identified in Table A, for example using binding agents capable of binding to said proteins.
- Suitable binding agents may comprise or consist of an antibody or an antigen-binding fragment thereof, such as intact antibodies, Fv fragments (e.g. single chain Fv and disulphide-bonded Fv), Fab-like fragments (e.g. Fab fragments, Fab' fragments and F(ab) 2 fragments), single variable domains (e.g. V H and V L domains) and domain antibodies (dAbs, including single and dual formats [i.e. dAb-linker-dAb]).
- Fv fragments e.g. single chain Fv and disulphide-bonded Fv
- Fab-like fragments e.g. Fab fragments, Fab' fragments and F(ab) 2 fragments
- single variable domains e.g. V H and V L domains
- dAbs including single and dual formats [i.e
- Suitable assays for detecting proteins include enzyme linked immunosorbent assays (ELISA), radioimmunoassay (RIA), immunoradiometric assays (IRMA) and immunoenzymatic assays (IEMA), including sandwich assays using monoclonal and/or polyclonal antibodies.
- ELISA enzyme linked immunosorbent assays
- RIA radioimmunoassay
- IRMA immunoradiometric assays
- IEMA immunoenzymatic assays
- sandwich assays are described by David et al in US Patent Nos. 4,376,110 and 4,486,530, hereby incorporated by reference.
- Antibody staining of cells on slides may be used in methods well known in cytology laboratory diagnostic tests, as well known to those skilled in the art.
- the presence and/or amount of the proteins selected from Table A may be determined by ELISA.
- the binding agent comprises or consists of an antibody-like binding agent, for example an affibody or aptamer.
- the proteins and/or mRNA in the sample may be labelled with a detectable moiety prior to performing step (b).
- a suitable detectable moiety is selected from the group consisting of: a fluorescent moiety; a luminescent moiety; a chemiluminescent moiety; a radioactive moiety; an enzymatic moiety.
- measuring the presence and/or amount of the proteins, or mRNA encoding the same, in the sample is performed using a gene expression profiling array.
- Suitable arrays include surface-based arrays and bead-based arrays, which may be macroarrays, microarrays or nanoarrays.
- the gene expression profiling array is commercially available.
- the GeneChip Human Genome U133 Plus 2.0 array from Affymetrix Inc, Santa Clara, USA.
- the method of the first aspect of the invention further comprises step (c) of comparing the presence and/or amount of the proteins, or mRNA encoding the same, with one or more reference values for said proteins or mRNA.
- reference value we mean a numerical value corresponding to the amount of a biomarker protein (or its mRNA) associated with a defined group of individuals.
- the reference values correspond to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals selected from a group consisting of healthy individuals, individuals diagnosed with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment and individuals diagnosed with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment.
- the reference values may correspond to the amount of the biomarker proteins or mRNA associated with individuals from the GEO dataset (Expression series GSE17920) diagnosed with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment and individuals from the GEO diagnosed with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment (see Example A below).
- step (b) the amount of the proteins, or mRNA encoding the same, obtained in step (b) and the reference values for said proteins or mRNA may be normalised prior to being compared.
- the comparison in step (c) may be performed manually but more typically will be performed using computer-based tools.
- step (c) comprises the use of a predictive model, such as a computer-implemented adaptive learning algorithm.
- the adaptive learning algorithm is an artificial neural network, e.g. a multilayer perceptron (see Example A below).
- an artificial neural network e.g. a multilayer perceptron (see Example A below).
- a biomarker signature for determining the responsiveness of Hodgkin's lymphoma patients to chemotherapy is reported with a predictive accuracy (AUC) of 0.837 based on gene expression profile data from 130 Hodgkin's lymphoma patients (GEO expression series GSE17920), compared to a predictive accuracy of only 0.625 using a clinical model based on the International Prognostic Score.
- AUC predictive accuracy
- the methods of the invention utilize a predictive model having an accuracy of at least 90% for determining the responsiveness of Hodgkin's lymphoma patients to chemotherapy.
- the predictive model may have an accuracy of at least 95% for such patient classification, and preferably at least 99%. It will be appreciated that such predictive accuracy may be determined relative to any given population of Hodgkin's lymphoma patients. In one embodiment, however, the predictive accuracy is determined relative to the 130 patients used in Example A (Expression series GSE17920 from the Gene Expression Omnibus [GEO] data repository).
- Example A The studies detailed in Example A below reveal that some proteins exhibit increased expression in individuals with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment whilst some proteins exhibit decreased expression in individuals with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment (compared to the expression of said proteins in individuals with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment).
- ZNF644, EMID2, RLN1 , SPATA12, CLPS, EST tu05b03.x1 , PDE6D, GET 4 and/or DCST2 is indicative of the individual with Hodgkin's lymphoma being responsive to chemotherapeutic drug treatment.
- EMID2, RLN1 , SPATA12, CLPS, EST tu05b03.x1 , PDE6D, GET 4 and/or DCST2 is indicative of the individual with Hodgkin's lymphoma being responsive to chemotherapeutic drug treatment.
- HSPA5, PTX3, C1orf163, KTN1 , MAPK14 and/or EPOR is indicative of the individual with Hodgkin's lymphoma being resistant to chemotherapeutic drug treatment.
- step (c) comprises identifying the individual as exhibiting atypical gene expression.
- atypical gene expression we mean that the gene expression profile for the dataset (e.g. patient group or sub-group) is qualitatively and/or quantitatively different from the gene expression profile most commonly observed in that dataset.
- the presence and/or amount of one or more proteins (or their respective mRNAs) may be quantitatively different from the presence and/or amount of said proteins or mRNAs most commonly observed in that dataset.
- the presence and/or amount of one or more (e.g. all) proteins in Table C may be atypical for a given subgroup of those patients (e.g. patients responsive or resistant to chemotherapy). Having identified a given patient as falling within the "outlier" subgroup, a different biomarker signature may be used to determiner whether said patient is responsive or resistant to chemotherapy.
- the methods of the invention may further comprise step (d) of determining the presence and/or amount in the sample of at least two proteins selected from the group identified in Table D, and/or of mRNA encoding the same.
- Table D lists all of the biomarkers identified herein as being differentially expressed (i.e. having an adjusted 'p'-value ['q'-value] of less than 0.05 in patients exhibiting an atypical or "outlier" gene expression profile; see Example A) in chemotherapy- responsive versus chemotherapy-resistant Hodgkin's lymphoma patients (see Example A below).
- step (d) it will be appreciated by persons skilled in that art that the methods described above in relation to step (b) may be used in step (d).
- step (d) comprises measuring the presence and/or amount in the sample of at least three proteins selected from the group identified in Table D, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table D, and/or mRNA encoding the same.
- step (d) may comprise measuring the presence and/or amount in the sample of at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table D, and/or mRNA encoding the same.
- the proteins, and/or mRNA encoding the same, measured in step (d) are selected from one of the following groups defined in Table D:
- Biomarker nos. 1 to 10 (b) Biomarker nos. 1 to 20;
- Biomarker nos. 1 to 1000 wherein the biomarker number is shown in first column of Table D ("No.”).
- step (d) may comprise measuring the presence and/or amount in the sample of at least one protein, and/or mRNA encoding the same, selected from the group consisting of
- Cytoglobin (e) Cytoglobin (CYGB);
- Zinc finger DHHC-type containing 9 (ZDHHC9).
- Step (d) comprises measuring the presence and/or amount in the sample of all of the following proteins, and/or mRNA encoding the same:
- the method further comprises step (e) of comparing the presence and/or amount of the proteins, or mRNA encoding the same, with one or more reference values for said proteins or mRNA.
- the reference values may correspond to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals selected from a group consisting of healthy individuals, individuals diagnosed with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment and individuals diagnosed with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment.
- step (e) the amount of the proteins, or mRNA encoding the same, obtained in step (e) and the reference values for said proteins or mRNA may be normalised prior to being compared.
- the method further comprises the step of determining the medical history of the individual.
- the medical history of the individual may comprise determining whether the patient has taken any HIV drug therapies prior to providing the sample.
- a second aspect of the invention provides a method for treating an individual with Hodgkin's lymphoma comprising:
- step (b) administering a chemotherapeutic drug to the individual identified in step (a).
- Suitable chemotherapeutic drug regimes effective in the treatment of Hodgkin's lymphoma are known to those skilled in the art.
- the individual may be administered 2 to 4 cycles of ABVD chemotherapy, which contains the drugs adriamycin (doxorubicin), bleomycin, vinblastine and dacarbazine.
- ABVD chemotherapy contains the drugs adriamycin (doxorubicin), bleomycin, vinblastine and dacarbazine.
- doxorubicin doxorubicin
- bleomycin bleomycin
- vinblastine dacarbazine
- dacarbazine dacarbazine
- Other possible chemotherapeutic drug combinations include:
- a related, third aspect of the invention provides a method for treating an individual with Hodgkin's lymphoma comprising:
- step (b) administering a therapeutic agent other than a chemotherapeutic drug to the individual identified in step (a).
- Suitable non-chemotherapeutic treatment regimes effective in the treatment of Hodgkin's lymphoma are known to those skilled in the art, for example radiotherapy.
- a fourth aspect of the invention provides a method for treating an individual with Hodgkin's lymphoma comprising:
- step (c) administering said effective therapeutic agent identified in step (b) to the individual.
- a fifth aspect of the invention provides an array for use in a method according to the first aspect of the invention the array comprising binding agents for two or more of the proteins identified in Table A and/or D, or mRNA encoding the same.
- Arrays per se are well known in the art. Typically they are formed of a linear or two- dimensional structure having spaced apart (i.e. discrete) regions ("spots"), each having a finite area, formed on the surface of a solid support.
- An array can also be ad structure where each bead can be identified by a molecular code or colour code or identified in a continuous flow. Analysis can also be performed sequentially where the sample is passed over a series of spots each adsorbing the class of molecules from the solution.
- the solid support is typically glass or a polymer, the most commonly used polymers being cellulose, polyacrylamide, nylon, polystyrene, polyvinyl chloride or polypropylene.
- the solid supports may be in the form of tubes, beads, discs, silicon chips, microplates, polyvinylidene difluoride (PVDF) membrane, nitrocellulose membrane, nylon membrane, other porous membrane, non-porous membrane (e.g. plastic, polymer, perspex, silicon, amongst others), a plurality of polymeric pins, or a plurality of microtitre wells, or any other surface suitable for immobilising proteins, polynucleotides and other suitable molecules and/or conducting an immunoassay.
- PVDF polyvinylidene difluoride
- binding processes are well known in the art and generally consist of cross-linking covalently binding or physically adsorbing a protein molecule, polynucleotide or the like to the solid support.
- affinity coupling of the probes via affinity-tags or similar constructs may be employed.
- contact or non-contact printing, masking or photolithography the location of each spot can be defined.
- the array is a microarray.
- microarray we include the meaning of an array of regions having a density of discrete regions of at least about 100/cm 2 , and preferably at least about 1000/cm 2 .
- the regions in a microarray have typical dimensions, e.g. diameter, in the range of between about 10-250 ⁇ , and are separated from other regions in the array by about the same distance.
- the array may alternatively be a macroarray or a nanoarray.
- the array comprises binding agents for fewer then 1000 different proteins, or mRNA coding the same, for example fewer than 500, 400, 300, 200, 100, 50, 25, or 20 different proteins, or mRNA coding the same.
- the array comprises binding agents for all of the proteins defined in Table 1 , or mRNA encoding the same.
- the array may comprise:
- the binding agents are immobilised.
- the array is a surface-based array or bead-based array.
- the array is suitable for use with high-throughput screening methods of gene profiling.
- a sixth aspect of the invention provides a kit for performing a method according to the first aspect of the invention comprising:
- kits further comprises one or more reagents for use in a method according to the first aspect of the invention.
- kits further comprises a positive control sample and/or a negative control sample.
- a seventh aspect of the invention provides a computer-implemented method for classifying a sample from an individual with Hodgkin's lymphoma, comprising:
- step (c) classifying said sample according to the output of said analytical process wherein one or more of the at least two proteins selected from the group defined in Table A is not identified in Table B. and wherein in step (c) the sample is classified as from an individual with Hodgkin's lymphoma who is responsive to chemotherapeutic drug treatment or from an individual with Hodgkin's lymphoma who is resistant to chemotherapeutic drug treatment.
- the dataset in step (a) comprises quantitative data for zinc finger protein 644 (ZNF644) and/or heat shock 70kDa protein 5 (HSPA5), and/or mRNA encoding the same.
- the dataset in step (a) comprises quantitative data for at least three proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table A, and/or mRNA encoding the same.
- the dataset in step (a) may comprise quantitative data for at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table A, and/or mRNA encoding the same.
- the proteins, and/or mRNA encoding the same, for which quantitative data are provided in step (a) are selected from one of the following groups defined in Table A: (a) Biomarker nos. 1 to 10
- none of the at least two proteins selected from the group identified in Table A are identified in Table B.
- the dataset in step (a) may comprise quantitative data for at least one protein, and/or mRNA encoding the same, selected from the group consisting of: (a) Zinc finger protein 644 (ZNF644) ;
- the dataset in step (a) may comprise quantitative data for all of biomarkers 'a' to 'o' above, and/or mRNA encoding the same.
- the dataset in step (a) comprises quantitative data for biomarkers 'a' to ⁇ ' above as measured at the mRNA level using the probe sets ("Probe ID's") identified in Table A (from the Affymetrix GeneChip Human Genome U133 Plus 2.0 array, from Affymetrix Inc, Santa Clara, USA).
- probe sets ("Probe ID's") identified in Table A (from the Affymetrix GeneChip Human Genome U133 Plus 2.0 array, from Affymetrix Inc, Santa Clara, USA).
- mRNA levels for heat shock 70kDa protein 5 may be determined using Affymetrix probe set 211936_at.
- the dataset in step (a) comprises quantitative data for at least two proteins selected from the group identified in Table D, and/or of mRNA encoding the same.
- the dataset in step (a) comprises quantitative data for at least three proteins selected from the group identified in Table D, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table D, and/or mRNA encoding the same.
- the dataset in step (a) comprises quantitative data for at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table D, and/or mRNA encoding the same.
- the proteins, and/or mRNA encoding the same, for which quantitative data are provided in step (a) are selected from one of the following groups defined in Table D:
- the dataset in step (a) comprises quantitative data for at least one protein, and/or mRNA encoding the same, selected from the group consisting of:
- Cytoglobin (e) Cytoglobin (CYGB);
- step (j) Zinc finger, DHHC-type containing 9 (ZDHHC9).
- the dataset in step (a) may comprise quantitative data for all of biomarkers 'a' to 'j' above, and/or mRNA encoding the same.
- the dataset in step (a) comprises quantitative data for all of the following proteins, and/or mRNA encoding the same:
- the dataset in step (a) may comprises quantitative data for biomarkers 'a' to 'j' above as measured at the mRNA level using the probe sets ("Probe ID's") identified in Table A (from the Affymetrix GeneChip Human Genome U133 Plus 2.0 array, from Affymetrix Inc, Santa Clara, USA).
- said analytical process in step (b) comprises the use of a predictive model based on the one or more reference datasets.
- step (b) may comprise the use of a Linear Discriminant Analysis (LDA) model, a support vector machine classification algorithm, a recursive feature elimination model, a prediction analysis of microarray model, a Logistic Regression model, a CART algorithm, a FlexTree algorithm, a LART algorithm, a random forest algorithm, a MART algorithm, or a Machine Learning algorithm.
- LDA Linear Discriminant Analysis
- said one or more reference datasets comprise quantitative data obtained from one or more individuals selected from a group consisting of healthy individuals, individuals diagnosed with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment and individuals diagnosed with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment.
- the analytical process in step (b) comprises use of an adaptive learning algorithm, such as an artificial neural network.
- the artificial neural network may be a multilayer perceptron.
- the predictive model has an accuracy of at least 90% for determining the responsiveness of Hodgkin's lymphoma patients to chemotherapy.
- the predictive model may have an accuracy of at least 95% for such patient classification, and preferably at least 99%.
- An eighth aspect of the invention provides a computer system for performing a computer- implemented method according to the seventh aspect of the invention, wherein the system comprises a digital computer and computer readable program means for enabling the computer to perform said computer-implemented method.
- the computer readable program may be contained within the internal or external memory of the computer system, for example on a RAM chip, hard- drive, CD-ROM, DVD-ROM, USB memory pen and the like.
- the computer system further comprises a computer-readable storage medium comprising reference datasets (i.e. from step 'b' of the computer- implemented method of the invention).
- a ninth aspect of the invention provides a computer-readable storage medium comprising computer readable program means for enabling the computer to perform a computer-implemented method according to the seventh aspect of the invention.
- the computer-readable storage medium further comprises reference datasets (i.e. from step 'b' of the computer-implemented method of the invention).
- the black boxes ( ⁇ ) represent the median value and suggests that the data are median centred and therefore appropriate for comparative analyses. Low and high part of the box represents the 25th and 75th percentile respectively. Minimum and maximum values are shown by the vertical thin lines.
- Figure 2 A general overview of a multi-layer perceptron back propagation network. Input signals are fed forward in a unidirectional manner (through weighted links) and transformed by an activation function into a predicted classification result. Error in classification is back propagated resulting in incremental changes to the weighted links and a minimisation of classification error.
- FIG. 3 Receiver Operating Characteristic (ROC) curve for 100 models retained after training for run 5 (sample seed variation). Plots represent the values obtained from all predictions made within training, testing and validation datasets.
- the true positive class represents patients who responded to treatment (i.e. chemo-sensitive).
- the true negative class are indicative of patients who did not respond to treatment (i.e. chemo-resistant).
- A Average predictive accuracy (%) for each sample.
- the mean value represents an average taken from 100 models per run with a total of 10 runs.
- a random sample seed with fixed network seed values were used to select training, testing and validation datasets and to initialise the network respectively.
- Chemotherapy failure patients are listed between sample numbers 1-38 and chemotherapy sensitive patients between sample numbers 39-130 respectively. Confidence intervals are shown at p ⁇ 0.05 two-tail t-distribution and 9 degrees of freedom (based upon 10 runs (generating 20,000 models per run)).
- the mean value represents an average taken from 100 models per run with a total of 10 runs.
- a fixed sample seed with random network seed values were used to select training, testing and validation datasets and to initialise the network respectively.
- Chemotherapy failure patients are listed between sample numbers 1-38 and chemotherapy sensitive patients between sample numbers 39-130 respectively. Confidence intervals are shown at p ⁇ 0.05 two-tail t- distribution and 9 degrees of freedom (based upon 10 runs (generating 20,000 models per run)).
- Figure 5 Average predictive accuracy for outlier samples.
- the mean value represents an average taken from 100 models per run with a total of 10 runs.
- a random sample seed with fixed network seed values were used to select training/testing/validation datasets and to initialise the network respectively.
- Chemotherapy failure patients (class F) and chemotherapy sensitive patients (class S) from "Sequential" and "Randomised” sample presentation are listed respectively. Confidence intervals are shown at p ⁇ 0.05 two-tail t- distribution and 9 degrees of freedom (based upon 10 runs (generating 20,000 models per run)).
- Figure 6 Number of genes with reported back from GE02R as having adjusted p-values ("q-values") with FDR ⁇ 0.05.
- Group 130 includes all 130 samples from the original study.
- Group 114 includes 114 samples with outlier samples removed.
- Group 16 includes the original 16 outlier samples only.
- Group 130, Group 114 and Group 16 contain both chemotherapy sensitive and resistant patient samples.
- Figure 7 Receiver Operating Characteristic (ROC) curve for 100 models for Group 130 samples using top 4 predictors identified as having the most significant adjusted p-values for Group 16 outlier samples. Plots represent the values obtained from all predictions made within training, testing and validation datasets.
- the true positive class (sensitivity) represents patients who responded to treatment (i.e. chemo-sensitive).
- the true negative class (specificity) are indicative of patients who did not respond to treatment (i.e. chemo- resistant).
Abstract
The present invention provides an in vitro method for determining the responsiveness of an individual with Hodgkin's lymphoma to chemotherapeutic drug treatment, the method comprising the steps of providing a protein or mRNA sample from a lymph node of the individual to be tested and then determining the presence and/or amount in the sample of at least two proteins selected from the group identified in Table A, and/or of mRNA encoding the same, wherein the presence and/or amount in the sample of the proteins selected from the group defined in Table A, or of the mRNA encoding the same, is indicative of the responsiveness of the individual with Hodgkin's lymphoma to chemotherapeutic drug treatment. The invention further provides arrays and kits for use in the same.
Description
NOVEL BIOMARKER SIGNATURE AND USES THEREOF
Field of Invention The present invention relates to novel biomarkers, and signatures comprising the same, for identifying individuals with Hodgkin's lymphoma who are responsive or resistant to treatment with chemotherapeutic agents.
Background
From a therapeutic perspective the management of patients with Hodgkin's lymphoma (HL) represents a challenging paradigm. As observed in other cancer groups, this is primarily manifested as a variation in the clinical response to chemotherapeutic intervention and presents phenotypically as one of three broad categorical groups: a) response; b) partial response; c) no response [1], [2]. This issue is further compounded by potential side effects elicited by toxicity to non-tumour cells and consequently introduces an additional complication to patient treatment protocols [3], [4], [5]. There is therefore an urgent need for molecular markers that are indicative for appropriate dosing strategies directed specifically towards the individual patient in addition to assays capable of identifying potential resistant/sensitive responses.
At the heart of these clinical issues is the genetic heterogeneity exhibited not only between individual patients with respect to their genomic DNA sequence, but also the somatic mutations that might arise as part of the evolutionary development of the tumour [6], [7], [8]. With respect to the latter, further complexity is exhibited in that mutations have been classified into two broad groups: a) "driver" mutations in which key cellular pathways are abrogated and begin to positively subvert the cellular machinery towards more aggressive phenotypes and b) "passenger" mutations which do not actively promote or abrogate the tumorigenic process but represent "background" noise [9], [10]. The ability to demarcate between mutations that drive aggressive phenotypes from those
that play no significant role in altering the clinical response to chemotherapy would provide potentially useful diagnostic assays with utility for triaging patients into those that may benefit from treatment versus those who are unlikely. With appropriate quantitation, characterisation and validation studies, these markers may also assist in dosing strategies for sensitive patients.
The present invention seeks to provide novel biomarkers for use in predicting the responsiveness of a patient with Hodgkin's lymphoma to chemotherapeutic drug treatment.
Summary of Invention
The invention provides methods of gene expression analysis in which a novel biomarker 'signature' is obtained to predict the responsiveness of a Hodgkin's lymphoma patient to chemotherapy, wherein the signature corresponds to quantitative information about the amount of a plurality of proteins (or mRNA encoding the same) which have been identified as characteristic of the responsiveness of said patient. Thus, a first aspect of the invention provides an in vitro method for determining the responsiveness of an individual with Hodgkin's lymphoma to chemotherapeutic drug treatment, the method comprising the steps of:
(a) providing a protein or mRNA sample from a lymph node of the individual to be tested;
(b) determining the presence and/or amount in the sample of at least two proteins selected from the group identified in Table 1 , and/or of mRNA encoding the same wherein one or more of the at least two proteins selected from the group identified in Table A is not identified in Table B and wherein the presence and/or amount in the sample of the proteins selected from the group identified in Table A, or of the mRNA encoding the same, is indicative of the responsiveness of the individual with Hodgkin's lymphoma to chemotherapeutic drug treatment.
Table A lists all of the biomarkers identified herein as being differentially expressed (i.e. having an adjusted 'p'-value ['q'-value] of less than 0.05 in patients exhibiting a typical gene expression profile; see Example A) in chemotherapy-responsive versus chemotherapy-resistant Hodgkin's lymphoma patients (see Example A below).
Table B lists eighty-six biomarkers previously known or suggested in the art as being of potential diagnostic value in differentiating chemotherapy-responsive from chemotherapy-resistant Hodgkin's lymphoma patients (see ref [34], in particular Table S5 of supplementary appendix therein; the disclosures of which are incorporated herein by reference).
In all tables herein, a positive log-fold change ('LogFC') indicates increased expression in chemotherapy-responsive versus chemotherapy-resistant Hodgkin's lymphoma patients, whilst a negative log-fold change ('LogFC') indicates increased expression in chemotherapy-resistant versus chemotherapy-responsive Hodgkin's lymphoma patients.
The individual being tested is typically a human. However, it will be appreciated that the methods may also be used for the diagnosis of any domestic or farm mammal (such as a horse, pig, cow, sheep, dog or cat).
By "chemotherapeutic drug treatment" we include any of the chemotherapeutic drug regimes commonly used clinically in the treatment of Hodgkin's lymphoma. For example, most people with early stage Hodgkin's lymphoma have 2 to 4 cycles of ABVD chemotherapy, which contains the drugs adriamycin (doxorubicin), bleomycin, vinblastine and dacarbazine. For advanced stage Hodgkin's lymphoma some people have ABVD for up to 8 cycles.
Other possible chemotherapeutic drug combinations include:
ChlvPP - chlorambucil, vinblastine, procarbazine and prednisolone
Stanford V - mustine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide and steroids
BEACOPP - bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisolone
If chemotherapy does not work well or the lymphoma comes back some people have "BEAM" chemotherapy with a stem cell transplant:
B = Carmustine (BiCNU)
E = Etoposide
A = Cytarabine (Ara-C, cytosine arabinoside)
M = Melphalan
By "responsiveness" in the context of chemotherapeutic drug treatment of an individual with Hodgkin's lymphoma we include the therapeutic effectiveness of the treatment with respect to Hodgkin's lymphoma. Thus, "responsiveness" includes the ability of chemotherapeutic drug treatment to reduce and most preferably prevent a clinically significant deficit in the activity, function and response of the individual with Hodgkin's lymphoma. For example, the measure of responsiveness may encompass the effect of the chemotherapeutic drug treatment on one or more of the following:
• the reduction of lymphoma cells within the individual;
• the growth and/or proliferation of lymphoma cells within the individual;
• the growth of tumours within the individual;
• the extent and/or rate of metastasis of tumours within the individual; and
· the life expectancy of the individual.
Step (a) of the methods of the invention comprises providing a protein or mRNA sample from the individual to be tested. Typically, the sample is a lymph node tumour biopsy sample (which may have been excised from the individual previously, for example at the time of diagnosis).
Alternatively, the sample may be a blood or serum sample. It will be appreciated by persons skilled in the art that the samples may be fresh-frozen or formalin-fixed.
In one embodiment, step (b) comprises measuring the presence and/or amount in the sample of at least three proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten,
eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table A, and/or mRNA encoding the same.
Thus, step (b) may comprise measuring the presence and/or amount in the sample of at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table A, and/or mRNA encoding the same
In one embodiment, the proteins and/or mRNA encoding the same measured in step (b) are selected from one of the following sub-groups defined in Table A:
(a) Biomarker nos. to 10;
(b) Biomarker nos. to 20;
(c) Biomarker nos, to 30;
(d) Biomarker nos, to 40;
(e) Biomarker nos, to 50;
(f) Biomarker nos, to 100;
(g) Biomarker nos, to 200;
(h) Biomarker nos, to 500;
(i) Biomarker nos to 1000;
(j) Biomarker nos, to 2000;
(k) Biomarker nos to 3000; or
(I) Biomarker nos to 4000. wherein the biomarker number is given in the first column of Table A ("No.").
For example, step (b) may comprise measuring the presence and/or amount in the sample of biomarker nos. 1 to 10 in Table A (i.e. the first ten biomarkers listed in Table A) and/or mRNA encoding the same
In one embodiment, none of the proteins from Table A selected in step (b) are identified in Table B. For example, the proteins selected may be absent from the tables of known differentially-expressed biomarkers disclosed in reference 34 (e.g. in supplementary tables 2, 3, 4 and/or 5).
In one preferred embodiment, step (b) comprises measuring the presence and/or amount in the sample of at least one protein, and/or mRNA encoding the same, selected from the group consisting of:
(a) Zinc finger protein 644 (ZNF644) ;
(b) Colipase, pancreatic (CLPS) ;
(c) EST tu05b03.x1 ;
(d) relaxin 1 (RLN1);
(e) phosphodiesterase 6D, cGMP-specific, rod, delta (PDE6D);
(0 EMI domain containing 2 (EMID2);
(g) heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa; HSPA5));
(h) spermatogenesis associated 12 (SPATA12);
(i) kinectin 1 (kinesin receptor; KTN1);
0') pentraxin 3, long (PTX3);
(k) erythropoietin receptor (EPOR);
(1) DC-STAMP domain containing 2 (DCST2);
(m) golgi to ER traffic protein 4 homolog (S. cerevisiae; GET4);
(n) mitogen-activated protein kinase 14 (MAPK14); and
(o) chromosome 1 open reading frame 163 (C1 orf163).
For example, (b) may comprise measuring the presence and/or amount in the sample of all of biomarkers 'a' to Ό' above, and/or mRNA encoding the same (see Table C).
Table C lists all of the biomarkers identified herein as being differentially expressed (i.e. having an adjusted 'p'-value ['q'-value] of less than 0.05 in patients; see Example A) in all chemotherapy-responsive versus chemotherapy-resistant Hodgkin's lymphoma patients (see Example A below).
Optionally, biomarkers 'a' to Ό' above are measured at the mRNA level using the probe sets ("Probe ID's") identified in Table A (from the Affymetrix GeneChip Human Genome U133 Plus 2.0 array, from Affymetrix Inc, Santa Clara, USA). For example, mRNA levels for heat shock 70kDa protein 5 may be determined using Affymetrix probe set 21 1936 at.
It will be appreciated by persons skilled in the art that gene expression of the biomarkers of the invention may be determined at either the protein or mRNA level (or both).
In one embodiment, step (b) comprises measuring the presence and/or amount in the sample of mRNA encoding the proteins selected from the group identified in Table A. Thus, measuring the presence and/or amount in the sample of the mRNA may be performed using binding agents capable of binding to the said mRNA, for example using oligonucleotides with a nucleotide sequence complementary to the target mRNA in a hybridisation assay.
In an alternative embodiment, step (b) comprises measuring the presence and/or amount in the sample of the proteins selected from the group identified in Table A, for example using binding agents capable of binding to said proteins. Suitable binding agents may comprise or consist of an antibody or an antigen-binding fragment thereof, such as intact antibodies, Fv fragments (e.g. single chain Fv and disulphide-bonded Fv), Fab-like fragments (e.g. Fab fragments, Fab' fragments and F(ab)2 fragments), single variable domains (e.g. VH and VL domains) and domain antibodies (dAbs, including single and dual formats [i.e. dAb-linker-dAb]).
Suitable assays for detecting proteins include enzyme linked immunosorbent assays (ELISA), radioimmunoassay (RIA), immunoradiometric assays (IRMA) and immunoenzymatic assays (IEMA), including sandwich assays using monoclonal and/or polyclonal antibodies. Exemplary sandwich assays are described by David et al in US Patent Nos. 4,376,110 and 4,486,530, hereby incorporated by reference. Antibody staining of cells on slides may be used in methods well known in cytology laboratory diagnostic tests, as well known to those skilled in the art.
For example, the presence and/or amount of the proteins selected from Table A may be determined by ELISA.
Conveniently, the binding agent comprises or consists of an antibody-like binding agent, for example an affibody or aptamer.
It will be appreciated by persons skilled in the art the proteins and/or mRNA in the sample may be labelled with a detectable moiety prior to performing step (b). A suitable detectable moiety is selected from the group consisting of: a fluorescent moiety; a luminescent moiety; a chemiluminescent moiety; a radioactive moiety; an enzymatic moiety.
In one embodiment, measuring the presence and/or amount of the proteins, or mRNA encoding the same, in the sample is performed using a gene expression profiling array. Suitable arrays include surface-based arrays and bead-based arrays, which may be macroarrays, microarrays or nanoarrays.
Conveniently, the gene expression profiling array is commercially available. For example, such as the GeneChip Human Genome U133 Plus 2.0 array, from Affymetrix Inc, Santa Clara, USA.
Optionally, the method of the first aspect of the invention further comprises step (c) of comparing the presence and/or amount of the proteins, or mRNA encoding the same, with one or more reference values for said proteins or mRNA. By "reference value" we mean a numerical value corresponding to the amount of a biomarker protein (or its mRNA) associated with a defined group of individuals.
Thus, in one embodiment the reference values correspond to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals selected from a group consisting of healthy individuals, individuals diagnosed with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment and individuals diagnosed with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment. For example, the reference values may correspond to the amount of the biomarker proteins or mRNA associated with individuals from the GEO dataset (Expression series GSE17920) diagnosed with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment and individuals from the GEO diagnosed with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment (see Example A below).
It will be appreciated by persons skilled in the art that the amount of the proteins, or mRNA encoding the same, obtained in step (b) and the reference values for said proteins or mRNA may be normalised prior to being compared.
The comparison in step (c) may be performed manually but more typically will be performed using computer-based tools.
In one embodiment, step (c) comprises the use of a predictive model, such as a computer-implemented adaptive learning algorithm.
In one preferred embodiment, the adaptive learning algorithm is an artificial neural network, e.g. a multilayer perceptron (see Example A below). One of the significant advantages of the methods of the present invention is the improved predictive accuracy of the biomarker signatures relative to existing methods for determining the responsiveness of Hodgkin's lymphoma patients to chemotherapy. For example, in reference 34 (Steidl et a/., 2010 NEJM, 362:875-885) a biomarker signature for determining the responsiveness of Hodgkin's lymphoma patients to chemotherapy is reported with a predictive accuracy (AUC) of 0.837 based on gene expression profile data from 130 Hodgkin's lymphoma patients (GEO expression series GSE17920), compared to a predictive accuracy of only 0.625 using a clinical model based on the International Prognostic Score. Using gene expression profile data from the same 130 Hodgkin's lymphoma patients, the methods of the present invention achieved a predictive accuracy (AUC) of 0.926 for all patients (see Example A below). However, following the identification and removal of patients with atypical gene expression profiles (so-called "outliers", of which 16 were identified), then 100% predictive accuracy was achieved with the remaining 114 patients. Moreover, a separate biomarker signature identified for use in the atypical "outlier" patient group also achieved 100% predictive accuracy (in the 16 patients).
From a clinical perspective, such improvements in predictive accuracy are highly significant, enabling clinicians to determine with much greater certainty an effective therapeutic regime for each individual patient.
Thus, in one embodiment, the methods of the invention utilize a predictive model having an accuracy of at least 90% for determining the responsiveness of Hodgkin's lymphoma patients to chemotherapy. For example, the predictive model may have an accuracy of at least 95% for such patient classification, and preferably at least 99%.
It will be appreciated that such predictive accuracy may be determined relative to any given population of Hodgkin's lymphoma patients. In one embodiment, however, the predictive accuracy is determined relative to the 130 patients used in Example A (Expression series GSE17920 from the Gene Expression Omnibus [GEO] data repository).
The studies detailed in Example A below reveal that some proteins exhibit increased expression in individuals with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment whilst some proteins exhibit decreased expression in individuals with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment (compared to the expression of said proteins in individuals with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment).
In one embodiment,
(a) an elevation in the amount of one or more of the following proteins (or mRNA encoding the same) relative to reference values corresponding to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment
HSPA5, PTX3, C1orf163, KTN1 , MAPK14 and/or EPOR and/or
(b) a decrease in the amount of one or more of the following proteins (or mRNA encoding the same) relative to reference values corresponding to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment
ZNF644, EMID2, RLN1 , SPATA12, CLPS, EST tu05b03.x1 , PDE6D, GET 4 and/or DCST2 is indicative of the individual with Hodgkin's lymphoma being responsive to chemotherapeutic drug treatment.
Likewise, in another embodiment,
(a) an elevation in the amount of one or more of the following proteins (or mRNA encoding the same) relative to reference values corresponding to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment ZNF644, EMID2, RLN1 , SPATA12, CLPS, EST tu05b03.x1 , PDE6D, GET 4 and/or DCST2 and/or (b) a decrease in the amount of one or more of the following proteins (or mRNA encoding the same) relative to reference values corresponding to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment
HSPA5, PTX3, C1orf163, KTN1 , MAPK14 and/or EPOR is indicative of the individual with Hodgkin's lymphoma being resistant to chemotherapeutic drug treatment.
In a further embodiment of the methods of the invention, step (c) comprises identifying the individual as exhibiting atypical gene expression.
By "atypical gene expression" we mean that the gene expression profile for the dataset (e.g. patient group or sub-group) is qualitatively and/or quantitatively different from the gene expression profile most commonly observed in that dataset. In particular, the presence and/or amount of one or more proteins (or their respective mRNAs) may be quantitatively different from the presence and/or amount of said proteins or mRNAs most commonly observed in that dataset.
For example, in the case of patients with Hodgkin's lymphoma, the presence and/or amount of one or more (e.g. all) proteins in Table C may be atypical for a given subgroup of those patients (e.g. patients responsive or resistant to chemotherapy). Having identified a given patient as falling within the "outlier" subgroup, a different biomarker signature may be used to determiner whether said patient is responsive or resistant to chemotherapy.
For example, the methods of the invention may further comprise step (d) of determining the presence and/or amount in the sample of at least two proteins selected from the group identified in Table D, and/or of mRNA encoding the same.
Table D lists all of the biomarkers identified herein as being differentially expressed (i.e. having an adjusted 'p'-value ['q'-value] of less than 0.05 in patients exhibiting an atypical or "outlier" gene expression profile; see Example A) in chemotherapy- responsive versus chemotherapy-resistant Hodgkin's lymphoma patients (see Example A below).
It will be appreciated by persons skilled in that art that the methods described above in relation to step (b) may be used in step (d).
In one embodiment, step (d) comprises measuring the presence and/or amount in the sample of at least three proteins selected from the group identified in Table D, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table D, and/or mRNA encoding the same.
For example, step (d) may comprise measuring the presence and/or amount in the sample of at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table D, and/or mRNA encoding the same.
In one embodiment, the proteins, and/or mRNA encoding the same, measured in step (d) are selected from one of the following groups defined in Table D:
Biomarker nos. 1 to 10
(b) Biomarker nos. 1 to 20;
(c) Biomarker nos. 1 to 30;
(d) Biomarker nos. 1 to 40;
(e) Biomarker nos. 1 to 50;
(f) Biomarker nos. 1 to 100;
(g) Biomarker nos. 1 to 200;
(h) Biomarker nos. 1 to 500; or
(i) Biomarker nos. 1 to 1000. wherein the biomarker number is shown in first column of Table D ("No.").
Thus, step (d) may comprise measuring the presence and/or amount in the sample of at least one protein, and/or mRNA encoding the same, selected from the group consisting of
(a) CD93 molecule (CD93);
(b) Gap junction protein, delta 3, 31.9 kDa (GJD3);
(c) Paired related homeobox 1 (PRRX1);
(d) Neuropilin 1 (NRP1);
(e) Cytoglobin (CYGB);
(f) Gamma-glutamyl transferase 5 (GGT5);
(g) Collagen, type VI, alpha 2 (COL6A2);
(h) Lysosomal protein transmembrane 4 beta (LAPTM4B);
(i) Dimethylarginine dimethylaminohydrolase 1 (DDAH1); and
0) Zinc finger, DHHC-type containing 9 (ZDHHC9).
For example, Step (d) comprises measuring the presence and/or amount in the sample of all of the following proteins, and/or mRNA encoding the same:
(a) CD93 molecule (CD93);
(b) Gap junction protein, delta 3, 31.9 kDa (GJD3);
(c) Paired related homeobox 1 (PRRX1); and
(d) Neuropilin 1 (NRP1).
In one embodiment, the method further comprises step (e) of comparing the presence and/or amount of the proteins, or mRNA encoding the same, with one or more reference values for said proteins or mRNA.
As in Step (b) above, the reference values may correspond to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals selected from a group consisting of healthy individuals, individuals diagnosed with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment and individuals diagnosed with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment.
Likewise, it will be appreciated by persons skilled in the art that the amount of the proteins, or mRNA encoding the same, obtained in step (e) and the reference values for said proteins or mRNA may be normalised prior to being compared.
In a further embodiment of the first aspect of the invention, the method further comprises the step of determining the medical history of the individual.
For example, the medical history of the individual may comprise determining whether the patient has taken any HIV drug therapies prior to providing the sample.
A second aspect of the invention provides a method for treating an individual with Hodgkin's lymphoma comprising:
(a) identifying an individual with Hodgkin's lymphoma who is responsive to chemotherapeutic drug treatment using a method according to the first aspect of the invention; and
(b) administering a chemotherapeutic drug to the individual identified in step (a).
Suitable chemotherapeutic drug regimes effective in the treatment of Hodgkin's lymphoma are known to those skilled in the art. For example, the individual may be administered 2 to 4 cycles of ABVD chemotherapy, which contains the drugs adriamycin (doxorubicin), bleomycin, vinblastine and dacarbazine. For advanced stage Hodgkin's lymphoma some people have ABVD for up to 8 cycles.
Other possible chemotherapeutic drug combinations include:
ChlvPP - chlorambucil, vinblastine, procarbazine and prednisolone
Stanford V - mustine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide and steroids
BEACOPP - bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisolone
A related, third aspect of the invention provides a method for treating an individual with Hodgkin's lymphoma comprising:
(a) identifying an individual with Hodgkin's lymphoma who is resistant to chemotherapeutic drug treatment using a method according to the first aspect of the invention; and
(b) administering a therapeutic agent other than a chemotherapeutic drug to the individual identified in step (a).
Suitable non-chemotherapeutic treatment regimes effective in the treatment of Hodgkin's lymphoma are known to those skilled in the art, for example radiotherapy.
A fourth aspect of the invention provides a method for treating an individual with Hodgkin's lymphoma comprising:
(a) determining the responsiveness of an individual with Hodgkin's lymphoma to chemotherapeutic drug treatment using a method according to the first aspect of the invention;
(b) identifying an effective therapeutic agent for administration to the individual based on the responsiveness of the patient to chemotherapeutic drug treatment; and
(c) administering said effective therapeutic agent identified in step (b) to the individual.
A fifth aspect of the invention provides an array for use in a method according to the first aspect of the invention the array comprising binding agents for two or more of the proteins identified in Table A and/or D, or mRNA encoding the same.
Arrays per se are well known in the art. Typically they are formed of a linear or two- dimensional structure having spaced apart (i.e. discrete) regions ("spots"), each having a finite area, formed on the surface of a solid support. An array can also be a bead structure where each bead can be identified by a molecular code or colour code or identified in a continuous flow. Analysis can also be performed sequentially where the sample is passed over a series of spots each adsorbing the class of molecules from the solution. The solid support is typically glass or a polymer, the most commonly used polymers being cellulose, polyacrylamide, nylon, polystyrene, polyvinyl chloride or polypropylene. The solid supports may be in the form of tubes, beads, discs, silicon chips, microplates, polyvinylidene difluoride (PVDF) membrane, nitrocellulose membrane, nylon membrane, other porous membrane, non-porous membrane (e.g. plastic, polymer, perspex, silicon, amongst others), a plurality of polymeric pins, or a plurality of microtitre wells, or any other surface suitable for immobilising proteins, polynucleotides and other suitable molecules and/or conducting an immunoassay. The binding processes are well known in the art and generally consist of cross-linking covalently binding or physically adsorbing a protein molecule, polynucleotide or the like to the solid support. Alternatively, affinity coupling of the probes via affinity-tags or similar constructs may be employed. By using well-known techniques, such as contact or non-contact printing, masking or photolithography, the location of each spot can be defined. For reviews see Jenkins, R.E., Pennington, S.R. (2001 , Proteomics, 2,13-29) and Lai et a/ (2002, Drug Discov Today 15;7(18 Suppl):S143-9).
Typically the array is a microarray. By "microarray" we include the meaning of an array of regions having a density of discrete regions of at least about 100/cm2, and preferably at least about 1000/cm2. The regions in a microarray have typical dimensions, e.g. diameter, in the range of between about 10-250 μιη, and are separated from other regions in the array by about the same distance. The array may alternatively be a macroarray or a nanoarray. In one embodiment, the array comprises binding agents for fewer then 1000 different proteins, or mRNA coding the same, for example fewer than 500, 400, 300, 200, 100, 50, 25, or 20 different proteins, or mRNA coding the same.
In one embodiment, the array comprises binding agents for all of the proteins defined in Table 1 , or mRNA encoding the same.
For example, the array may comprise:
(a) binding agents for all of the proteins identified in Table C, or mRNA encoding the same;
(b) binding agents for all of the proteins identified in Table A, or mRNA encoding the same;
(c) binding agents for all of the proteins identified in Table D, or mRNA encoding the same;
(d) binding agents for all of the proteins identified in Tables A and D; and/or
(e) binding agents for mRNA encoding all of the proteins in Tables A and D.
In one embodiment, the binding agents are immobilised.
In one embodiment, the array is a surface-based array or bead-based array.
In one embodiment, the array is suitable for use with high-throughput screening methods of gene profiling.
A sixth aspect of the invention provides a kit for performing a method according to the first aspect of the invention comprising:
(a) an array according to the fifth aspect of the invention; and
(b) instructions for performing a method according to the first aspect of the invention. In one embodiment, the kit further comprises one or more reagents for use in a method according to the first aspect of the invention.
In one embodiment, the kit further comprises a positive control sample and/or a negative control sample.
A seventh aspect of the invention provides a computer-implemented method for classifying a sample from an individual with Hodgkin's lymphoma, comprising:
(a) providing a dataset associated with the sample, wherein said dataset comprises quantitative data for at least two proteins, and/or mRNA encoding the same, selected from the group defined in Table A;
(b) inputting said dataset into an analytical process on a computer that compares said dataset against one or more reference datasets; and
(c) classifying said sample according to the output of said analytical process wherein one or more of the at least two proteins selected from the group defined in Table A is not identified in Table B. and wherein in step (c) the sample is classified as from an individual with Hodgkin's lymphoma who is responsive to chemotherapeutic drug treatment or from an individual with Hodgkin's lymphoma who is resistant to chemotherapeutic drug treatment.
In one embodiment, the dataset in step (a) comprises quantitative data for zinc finger protein 644 (ZNF644) and/or heat shock 70kDa protein 5 (HSPA5), and/or mRNA encoding the same.
In one embodiment, the dataset in step (a) comprises quantitative data for at least three proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table A, and/or mRNA encoding the same.
For example, the dataset in step (a) may comprise quantitative data for at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table A, and/or mRNA encoding the same.
In one embodiment, the proteins, and/or mRNA encoding the same, for which quantitative data are provided in step (a) are selected from one of the following groups defined in Table A:
(a) Biomarker nos. 1 to 10
(b) Biomarker nos. 1 to 20
(c) Biomarker nos. 1 to 30
(d) Biomarker nos. 1 to 40
(e) Biomarker nos. 1 to 50
(f) Biomarker nos. 1 to 100;
(g) Biomarker nos. 1 to 200;
(h) Biomarker nos. 1 to 500;
(i) Biomarker nos. 1 to 1000;
(j) Biomarker nos. 1 to 2000;
(k) Biomarker nos. 1 to 3000; or
(1) Biomarker nos. 1 to 4000.
In one embodiment, none of the at least two proteins selected from the group identified in Table A are identified in Table B.
In one embodiment, the dataset in step (a) may comprise quantitative data for at least one protein, and/or mRNA encoding the same, selected from the group consisting of: (a) Zinc finger protein 644 (ZNF644) ;
(b) Colipase, pancreatic (CLPS) ;
(c) EST tu05b03.x1 ;
(d) relaxin 1 (RLN1 );
(e) phosphodiesterase 6D, cGMP-specific, rod, delta (PDE6D);
(f) EMI domain containing 2 (EMID2);
(g) heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa; HSPA5));
(h) spermatogenesis associated 12 (SPATA12);
(i) kinectin 1 (kinesin receptor; KTN1);
0) pentraxin 3, long (PTX3);
(k) erythropoietin receptor (EPOR);
(I) DC-STAMP domain containing 2 (DCST2);
(m) golgi to ER traffic protein 4 homolog (S. cerevisiae; GET4);
(n) mitog en-activated protein kinase 14 (MAPK14); and
(o) chromosome 1 open reading frame 163 (C1 orf163).
For example, the dataset in step (a) may comprise quantitative data for all of biomarkers 'a' to 'o' above, and/or mRNA encoding the same.
Optionally, the dataset in step (a) comprises quantitative data for biomarkers 'a' to Ό' above as measured at the mRNA level using the probe sets ("Probe ID's") identified in Table A (from the Affymetrix GeneChip Human Genome U133 Plus 2.0 array, from Affymetrix Inc, Santa Clara, USA). For example, mRNA levels for heat shock 70kDa protein 5 may be determined using Affymetrix probe set 211936_at. In one embodiment, the dataset in step (a) comprises quantitative data for at least two proteins selected from the group identified in Table D, and/or of mRNA encoding the same.
Thus, the dataset in step (a) comprises quantitative data for at least three proteins selected from the group identified in Table D, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table D, and/or mRNA encoding the same. For example, the dataset in step (a) comprises quantitative data for at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table D, and/or mRNA encoding the same.
In one embodiment, the proteins, and/or mRNA encoding the same, for which quantitative data are provided in step (a) are selected from one of the following groups defined in Table D:
(a) Biomarker nos. 1 to 10
(b) Biomarker nos, 1 to 20
(c) Biomarker nos 1 to 30
(d) Biomarker nos, 1 to 40
(e) Biomarker nos. 1 to 50
(f) Biomarker nos. 1 to 100;
(g) Biomarker nos, 1 to 200;
(h) Biomarker nos, 1 to 500; or
(i) Biomarker nos, 1 to 1000.
In one embodiment, the dataset in step (a) comprises quantitative data for at least one protein, and/or mRNA encoding the same, selected from the group consisting of:
(a) CD93 molecule (CD93);
(b) Gap junction protein, delta 3, 31.9 kDa (GJD3);
(c) Paired related homeobox 1 (PRRX1);
(d) Neuropilin 1 (NRP1);
(e) Cytoglobin (CYGB);
(f) Gamma-glutamyl transferase 5 (GGT5);
(g) Collagen, type VI, alpha 2 (COL6A2);
(h) Lysosomal protein transmembrane 4 beta (LAPTM4B);
(i) Dimethylarginine dimethylaminohydrolase 1 (DDAH1); and
(j) Zinc finger, DHHC-type containing 9 (ZDHHC9). For example, the dataset in step (a) may comprise quantitative data for all of biomarkers 'a' to 'j' above, and/or mRNA encoding the same.
In one embodiment, the dataset in step (a) comprises quantitative data for all of the following proteins, and/or mRNA encoding the same:
(a) CD93 molecule (CD93);
(b) Gap junction protein, delta 3, 31.9 kDa (GJD3);
(c) Paired related homeobox 1 (PRRX1); and
(d) Neuropilin 1 (NRP1).
Optionally, the dataset in step (a) may comprises quantitative data for biomarkers 'a' to 'j' above as measured at the mRNA level using the probe sets ("Probe ID's") identified in Table A (from the Affymetrix GeneChip Human Genome U133 Plus 2.0 array, from Affymetrix Inc, Santa Clara, USA).
In one embodiment, wherein the dataset in step (a) and the reference datasets are normalised.
In one embodiment, said analytical process in step (b) comprises the use of a predictive model based on the one or more reference datasets.
For example, step (b) may comprise the use of a Linear Discriminant Analysis (LDA) model, a support vector machine classification algorithm, a recursive feature elimination model, a prediction analysis of microarray model, a Logistic Regression model, a CART algorithm, a FlexTree algorithm, a LART algorithm, a random forest algorithm, a MART algorithm, or a Machine Learning algorithm.
In one embodiment, said one or more reference datasets comprise quantitative data obtained from one or more individuals selected from a group consisting of healthy individuals, individuals diagnosed with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment and individuals diagnosed with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment.
In one embodiment, the analytical process in step (b) comprises use of an adaptive learning algorithm, such as an artificial neural network.
For example, the artificial neural network may be a multilayer perceptron.
In one embodiment, the predictive model has an accuracy of at least 90% for determining the responsiveness of Hodgkin's lymphoma patients to chemotherapy. For example, the predictive model may have an accuracy of at least 95% for such patient classification, and preferably at least 99%.
It will be appreciated that such predictive accuracy may be determined relative to any given population of Hodgkin's lymphoma patients. In one embodiment, however, the predictive accuracy is determined relative to the 130 patients used in Example A (Expression series GSE17920 from the Gene Expression Omnibus [GEO] data repository).
An eighth aspect of the invention provides a computer system for performing a computer- implemented method according to the seventh aspect of the invention, wherein the system comprises a digital computer and computer readable program means for enabling the computer to perform said computer-implemented method.
It will be appreciated that the computer readable program may be contained within the internal or external memory of the computer system, for example on a RAM chip, hard- drive, CD-ROM, DVD-ROM, USB memory pen and the like.
In one embodiment, the computer system further comprises a computer-readable storage medium comprising reference datasets (i.e. from step 'b' of the computer- implemented method of the invention).
Using such a system, the operator simply needs to input the dataset associated with the sample to be tested (i.e. step 'a' of the computer-implemented method of the invention) and then run the program. A ninth aspect of the invention provides a computer-readable storage medium comprising computer readable program means for enabling the computer to perform a computer-implemented method according to the seventh aspect of the invention.
In one embodiment, the computer-readable storage medium further comprises reference datasets (i.e. from step 'b' of the computer-implemented method of the invention).
Preferred, non-limiting examples which embody certain aspects of the invention will now be described, with reference to the following figures.
Figure 1 : Box plots for resistant (samples 1-38) and sensitive (samples 39-130) patient microarray values (n=54,675) taken from log2 normalised expression values. The black boxes (■) represent the median value and suggests that the data are median centred and therefore appropriate for comparative analyses. Low and high part of the box represents the 25th and 75th percentile respectively. Minimum and maximum values are shown by the vertical thin lines.
Figure 2: A general overview of a multi-layer perceptron back propagation network. Input signals are fed forward in a unidirectional manner (through weighted links) and transformed by an activation function into a predicted classification result. Error in classification is back propagated resulting in incremental changes to the weighted links and a minimisation of classification error.
Figure 3: Receiver Operating Characteristic (ROC) curve for 100 models retained after training for run 5 (sample seed variation). Plots represent the values obtained from all predictions made within training, testing and validation datasets. The true positive class
(sensitivity) represents patients who responded to treatment (i.e. chemo-sensitive). The true negative class (specificity) are indicative of patients who did not respond to treatment (i.e. chemo-resistant). Figure 4:
(A) Average predictive accuracy (%) for each sample. The mean value represents an average taken from 100 models per run with a total of 10 runs. A random sample seed with fixed network seed values were used to select training, testing and validation datasets and to initialise the network respectively. Chemotherapy failure patients are listed between sample numbers 1-38 and chemotherapy sensitive patients between sample numbers 39-130 respectively. Confidence intervals are shown at p<0.05 two-tail t-distribution and 9 degrees of freedom (based upon 10 runs (generating 20,000 models per run)).
(B) Average predictive accuracy (%) for each sample. The mean value represents an average taken from 100 models per run with a total of 10 runs. A fixed sample seed with random network seed values were used to select training, testing and validation datasets and to initialise the network respectively. Chemotherapy failure patients are listed between sample numbers 1-38 and chemotherapy sensitive patients between sample numbers 39-130 respectively. Confidence intervals are shown at p<0.05 two-tail t- distribution and 9 degrees of freedom (based upon 10 runs (generating 20,000 models per run)).
Figure 5: Average predictive accuracy for outlier samples. The mean value represents an average taken from 100 models per run with a total of 10 runs. A random sample seed with fixed network seed values were used to select training/testing/validation datasets and to initialise the network respectively. Chemotherapy failure patients (class F) and chemotherapy sensitive patients (class S) from "Sequential" and "Randomised" sample presentation are listed respectively. Confidence intervals are shown at p<0.05 two-tail t- distribution and 9 degrees of freedom (based upon 10 runs (generating 20,000 models per run)).
Figure 6: Number of genes with reported back from GE02R as having adjusted p-values ("q-values") with FDR <0.05. Group 130 includes all 130 samples from the original study. Group 114 includes 114 samples with outlier samples removed. Group 16 includes the original 16 outlier samples only. Group 130, Group 114 and Group 16 contain both chemotherapy sensitive and resistant patient samples.
Figure 7: Receiver Operating Characteristic (ROC) curve for 100 models for Group 130 samples using top 4 predictors identified as having the most significant adjusted p-values for Group 16 outlier samples. Plots represent the values obtained from all predictions made within training, testing and validation datasets. The true positive class (sensitivity) represents patients who responded to treatment (i.e. chemo-sensitive). The true negative class (specificity) are indicative of patients who did not respond to treatment (i.e. chemo- resistant).
TABLE A
Statistical overview of gene biomarkers identified as being differentially expressed between chemotherapy resistant and sensitive Hodgkin's lymphoma patients
RIBC1 235946 at 7.6941 E-04 8.87E-07 5.20 5.47 2.50E-01
SIPA1 L2 233587 s at 7.8609E-04 9.20E-07 -5.19 5.43 -5.11 E-01
NCRNA002 225698_at 8.6294E-04 1.03E-06 5.16 5.33 8.18E-01 19
PDIA4 208658 at 8.6294E-04 1.04E-06 -5.16 5.32 -5.69E-01
TMEM37 1554485 s at 9.1213E-04 1.12E-06 -5.14 5.26 -7.42E-01
ELOVL5 215082 at 9.3749E-04 1.17E-06 5.13 5.22 9.46E-01
RPL38 202029 x at 9.3749E-04 1.18E-06 5.13 5.20 2.73E-01
MS4A4A 219607 s at 9.7933E-04 1.25E-06 -5.12 5.15 -1.50E+00
ASPH 225008 at 9.9547E-04 1.29E-06 -5.11 5.12 -6.38E-01
EPB41 L3 212681 at 1.0046E-03 1.33E-06 -5.10 5.10 -8.75E-01
SLC02B1 203472 s at 1.0046E-03 1.41 E-06 -5.09 5.04 -7.72E-01
AP2A2 212159 x at 1.0046E-03 1.42E-06 -5.09 5.04 -8.16E-01
235438 at 1.0046E-03 1.43 E-06 -5.09 5.03 -6.90E-01
PTGS1 215813 s at 1.0046E-03 1.43E-06 -5.09 5.03 -1.04E+00
PRKAR2A 225011 at 1.0046E-03 1.44E-06 -5.09 5.03 -3.87E-01
FNDC3B 222692 s at 1.0046E-03 1.44E-06 -5.09 5.02 -6.58E-01
PPAP2B 209355 s at 1.0046E-03 1.49E-06 -5.08 4.99 -1.15E+00
ATN1 211076 x at 1.0046E-03 1.50E-06 5.08 4.99 2.11 E-01
ASPH 205808 at 1.0046E-03 1.52E-06 -5.07 4.97 -3.51 E-01
RPL22 208768 x at 1.0046E-03 1.53E-06 5.07 4.97 2.64E-01
SNHG6 225547 at 1.0046E-03 1.54E-06 5.07 4.97 6.33E-01 BNL1 233015 at 1.0046E-03 1.55E-06 5.07 4.96 4.04E-01
RPL12 200088 x at 1.0046E-03 1.56E-06 5.07 4.95 2.53E-01
ACSL1 207275 s at 1.0871 E-03 1.72E-06 -5.05 4.86 -1.03E+00 S4A4A 224357 s at 1.0871 E-03 1.73E-06 -5.04 4.86 -8.75E-01
LOC653506/ 225955_at 1.1197E-03 1.80E-06 -5.03 4.82 -1.01 E+00 //METRNL
237442 at 1.1650E-03 1.90E-06 5.02 4.77 5.91 E-01
PTAFR 206278 at 1.1650E-03 1.92E-06 -5.02 4.76 -5.28E-01
CTNNA1 200764 s at 1.1684E-03 1.98E-06 -5.01 4.73 -7.05 E-01
C20orf112 230955 s at 1.1684E-03 2.00E-06 5.01 4.72 3.30E-01
RETSAT 1566472 s at 1.1684E-03 2.01 E-06 -5.01 4.72 -3.82E-01
LOC374443 238790 at 1.1684E-03 2.03 E-06 5.01 4.71 6.57E-01
RTN4 210968 s at 1.1684E-03 2.04E-06 -5.00 4.71 -5.61 E-01
RNF19B 213038 at 1.1684E-03 2.05E-06 -5.00 4.70 -7.27E-01
HELQ 1554342 s at 1.1750E-03 2.08E-06 5.00 4.69 5.36E-01
APLP2 208702 x at 1.2063E-03 2.18E-06 -4.99 4.64 -7.07E-01
UBC///UBB// 208980_s_at 1.2063E-03 2.18E-06 -4.99 4.64 -7.24E-01 /RPS27A
ANBA 203778 at 1.2236E-03 2.24E-06 -4.98 4.62 -3.47E-01
FCGR2C 211395 x at 1.2281 E-03 2.27E-06 -4.98 4.61 -1.13E+00
CFI 1555564 a at 1.2364E-03 2.31 E-06 -4.98 4.59 -6.23E-01
TRIM27 212116 at 1.2835E-03 2.42E-06 -4.96 4.55 -3.76E-01
PRKACB 235780 at 1.2855E-03 2.45E-06 4.96 4.54 7.45E-01
ATP2A2 212361 s at 1.2980E-03 2.49E-06 -4.96 4.52 -7.47E-01
C19orf10 221739_at 1.3520E-03 2.67E-06 -4.94 4.46 -3.75E-01
228685 at 1.3520E-03 2.68E-06 -4.94 4.46 -3.55E-01
MPZL1 210087 s at 1.3520E-03 2.69E-06 -4.94 4.45 -5.98E-01
AGRN 212283 at 1.3520E-03 2.72E-06 4.94 4.44 3.71 E-01
RBPJ 207785 s at 1.3520E-03 2.72E-06 -4.94 4.44 -6.61 E-01
239237 at 1.3547E-03 2.77E-06 4.93 4.43 5.31 E-01
CD209 207277_at 1.3547E-03 2.78E-06 -4.93 4.42 -1.47E+00
TNFSF12- 209500_x_at 1.3730E-03 2.84E-06 -4.93 4.40 -6.52E-01 TNFSF13///
TNFSF12///
TNFSF13
RPL34 200026 at 1.3839E-03 2.89E-06 4.92 4.39 3.16E-01
STIP1 213330 s at 1.3842E-03 2.91 E-06 -4.92 4.38 -6.62E-01
FAM76B 232048 at 1.3849E-03 2.94E-06 4.92 4.37 2.97E-01
TGM2 201042 at 1.3972E-03 3.00E-06 -4.91 4.35 -1.25E+00
SP4 236265 at 1.3972E-03 3.03E-06 4.91 4.34 4.93E-01
LHFP 231411 at 1.3972E-03 3.07E-06 -4.91 4.33 -5.01 E-01
TRMT11 218877 s at 1.3972E-03 3.07E-06 4.91 4.33 3.83E-01
FAM20A 226804 at 1.4555E-03 3.22E-06 -4.90 4.29 -9.63E-01
RPL22 220960 x at 1.5163E-03 3.38E-06 4.89 4.24 1.80E-01
OSMR 205729 at 1.5299E-03 3.44E-06 -4.88 4.23 -4.76E-01
CALH 2 57715 at 1.5540E-03 3.54E-06 -4.87 4.20 -4.86E-01
TTL 224908 s at 1.5540E-03 3.55E-06 -4.87 4.20 -4.19E-01
Wo. Gene* Probe ID** Adj. p value P value f B Log FC
126 EARS2 227374 at 1.5810E-03 3.64E-06 -4.87 4.17 -2.82E-01
127 LOC729513/ 244766_at 1.6005E-03 3.76E-06 4.86 4.15 5.24E-01 //LOC64129
8///LOC5951
01///LOC440
354///SMG1
128 RPS20 200949 x at 1.6005E-03 3.77E-06 4.86 4.14 3.85E-01
129 FILIP1 L 204135 at 1.6005E-03 3.80E-06 -4.86 4.14 -7.77E-01
130 MEX3D 91816 f at 1.6005E-03 3.82E-06 -4.86 4.13 -1.93E-01
131 ITPRIPL2 227514 at 1.6005E-03 3.85E-06 -4.85 4.12 -7.43E-01
132 APP 214953 s at 1.6005E-03 3.88E-06 -4.85 4.12 -7.70E-01
133 VAMP3 211749 s at 1.6005E-03 3.91 E-06 -4.85 4.11 -7.24E-01
134 PEA15 200788 s at 1.6005E-03 3.94E-06 -4.85 4.10 -5.81 E-01
135 LOC284900 244189 at 1.6005E-03 3.95E-06 4.85 4.10 9.69E-01
136 229716 at 1.6547E-03 4.12E-06 4.84 4.06 9.35E-01
137 C16orf72 220743 at 1.6883E-03 4.23 E-06 4.83 4.04 3.83 E-01
138 FILIP1 1570515 a at 1.6946E-03 4.28E-06 -4.83 4.03 -3.82E-01
139 CTNS 36566 at 1.7071E-03 4.34E-06 -4.83 4.02 -4.99E-01
140 RXRA 202449 s at 1.7302E-03 4.43E-06 -4.82 4.00 -5.69E-01
141 FAM169A 235048 at 1.7365E-03 4.50E-06 4.82 3.98 6.29E-01
142 MS4A4A 1555728 a at 1.7365E-03 4.51 E-06 -4.82 3.98 -1.46E+00
143 1556346 at 1.7365E-03 4.54E-06 4.81 3.97 3.85E-01
144 230856 at 1.7400E-03 4.58E-06 4.81 3.97 5.29E-01
145 CALHM2 221565 s at 1.7581 E-03 4.66E-06 -4.81 3.95 -5.41 E-01
146 CCDC57 227783 at 1.7745E-03 4.75E-06 4.80 3.93 4.61 E-01
147 KPNB1 213803.at 1 J745E-03 4.77E-06 -4.80 3.93 -6.94E-01
148 ATRN 212517 at 1.7826E-03 4.83E-06 -4.80 3.92 -4.26E-01
149 RBMS1 203748_x_at 1.7826E-03 4.86 E-06 -4.80 3.91 -7.04E-01
150 GPATCH2 1556126_s_at 1.7832E-03 4.92E-06 4.80 3.90 4.81 E-01
151 RBMS1 207266_x_at 1.7832E-03 4.95E-06 -4.79 3.89 -7.11 E-01
152 ELOVL6 204256 at 1.7832E-03 4.96E-06 -4.79 3.89 -3.53E-01
153 DOCK7 225384 at 1 J969E-03 5.03 E-06 -4.79 3.88 -4.99E-01
154 SLC44A1 228485 s at 1.8092E-03 5.10E-06 -4.79 3.87 -4.88E-01
155 ACSL1 201963 at 1.8205E-03 5.16E-06 -4.78 3.86 -7.61 E-01
156 GET4 224816 at 1.8301E-03 5.22E-06 4.78 3.85 2.12E-01
157 PLTP 202075 s at 1.8425E-03 5.34E-06 -4.78 3.83 -1.87E+00
158 ALOX5 204445 s at 1.8425E-03 5.37E-06 -4.77 3.82 -5.95E-01
159 ANTXR2 225524 at 1.8425E-03 5.39E-06 -4.77 3.82 -7.42E-01
160 CD44 204489 s at 1.8425E-03 5.43 E-06 -4.77 3.81 -5.40E-01
161 CD44 212063 at 1.8425E-03 5.52E-06 -4.77 3.80 -5.25E-01
162 FAU 200019 s at 1.8425E-03 5.53E-06 4.77 3.79 4.13E-01
163 C19orf10 216483 s at 1.8425E-03 5.53E-06 -4.77 3.79 -7.15E-01
164 NFE2L2 201146 at 1.8425E-03 5.58E-06 -4.77 3.79 -4.78E-01
165 TTC35 203584 at 1.8425E-03 5.59E-06 -4.76 3.78 -6.23E-01
166 HLA-DRB1 208306 x at 1.8425E-03 5.59E-06 -4.76 3.78 -6.52E-01
167 C1R 212067 s at 1.8552E-03 5.72E-06 -4.76 3.76 -9.51 E-01
168 ATP1 B3 208836 at 1.8552E-03 5.73E-06 -4.76 3.76 -4.03E-01
169 FILIP1 L 1554966 a at 1.8552E-03 5.73E-06 -4.76 3.76 -9.70E-01
170 CXorf36 222911 s at 1.8577E-03 5.80E-06 -4.76 3.75 -3.53E-01
171 SLC02B1 211557 x at 1.8577E-03 5.81 E-06 -4.76 3.75 -6.15E-01
172 FAM105B 240834 at 1.8592E-03 5.85E-06 4.75 3.74 2.50E-01
173 225567 at 1.8664E-03 5.98E-06 -4.75 3.72 -8.34E-01
174 GTSF1 L 232820 s at 1.8664E-03 6.05E-06 4.75 3.71 4.33E-01
175 FBLIM1 1554795 a at 1.8664E-03 6.07E-06 -4.74 3.71 -2.70E-01
176 209353 s at 1.8664E-03 6.10E-06 4.74 3.70 1.75E-01
177 SIPA1 L2 225056 at 1.8664E-03 6.13E-06 -4.74 3.70 -6.16E-01
178 SLC36A2/// 214143_x_at 1.8664E-03 6.20E-06 4.74 3.69 2.94E-01 RPL24
179 CD44 210916 s at 1.8664E-03 6.20E-06 -4.74 3.69 -8.03E-01
180 FKBP1A 214119 s at 1.8664E-03 6.21 E-06 -4.74 3.69 -5.98E-01
181 PTGS1 205128 x at 1.8664E-03 6.25E-06 -4.74 3.68 -8.34E-01
182 237726 at 1.8664E-03 6.28E-06 4.74 3.68 1.79E-01
183 MARCO 205819 at 1.8664E-03 6.30E-06 -4.74 3.67 -1.28E+00
184 RPL37 200092 s at 1.8664E-03 6.31 E-06 4.74 3.67 1 J8E-01
185 THBD 203888 at 1.8664E-03 6.32E-06 -4.74 3.67 -6.36E-01
186 RHBG 220510 at 1.8685E-03 6.38E-06 4.73 3.66 3.05E-01
187 STXBP4 1554328 at 1.8685E-03 6.43E-06 4.73 3.66 1.63E-01
188 P4HB 200656 s at 1.8685E-03 6.46E-06 -4.73 3.65 -9.32E-01
189 PMS2L1 214756 x at 1.8685E-03 6.46E-06 4.73 3.65 4.41 E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
190 222877 at 1.8738E-03 6.51 E-06 -4.73 3.65 -8.01 E-01
191 TNFSF13 210314 x at 1.8943E-03 6.63E-06 -4.72 3.63 -6.81 E-01
192 SIGLEC10 1552806 a at 1.8943E-03 6.67E-06 -4.72 3.62 -1.05E+00
193 FLJ42291 238648 at 1.8943E-03 6.69E-06 4.72 3.62 2.15E-01
194 DNAJA1 200881 s at 1.9089E-03 6.81 E-06 -4.72 3.60 -6.60E-01
195 SIL1 218436 at 1.9089E-03 6.82E-06 -4.72 3.60 -4.41 E-01
196 OAF 225510 at 1.9089E-03 6.89E-06 -4.71 3.59 -5.26E-01
197 Sep-02 200015 s at 1.9089E-03 6.91 E-06 -4.71 3.59 -3.51 E-01
198 RORB 206443 at 1.9089E-03 6.93E-06 4.71 3.59 1.71 E-01
199 CLEC2D 235522 at 1.9089E-03 6.95E-06 4.71 3.59 4.36E-01
200 LOC153328 231372 at 1.9089E-03 7.07E-06 -4.71 3.57 -5.29E-01
201 1557409 at 1.9089E-03 7.11 E-06 4.71 3.57 2.26E-01
202 LOC441259/ 213893_x_at 1.9089E-03 7.12E-06 4.71 3.56 4.04E-01
//PMS2L5///
P S2L2
203 RNF135 223591_at 1.9089E-03 7.14E-06 -4.71 3.56 -6.1 1E-01
204 FKBP11 219118 at 1.9089E-03 7.16E-06 -4.70 3.56 -7.54E-01
205 PRUNE2 212806 at 1.9089E-03 7.16E-06 4.70 3.56 1.95E-01
206 AFB 222670 s at 1.9179E-03 7.24E-06 -4.70 3.55 -8.49E-01
207 RPL14 213588 x at 1.9179E-03 7.26 E-06 4.70 3.55 2.67E-01
208 ST 17A 202694 at 1.9560E-03 7.44E-06 4.70 3.52 4.42E-01
209 CTTNBP2N 231822_at 1.9859E-03 7.67E-06 -4.69 3.50 -3.54E-01 L
210 Y E1 L1 232216 at 1.9859E-03 7.74E-06 4.69 3.49 4.94E-01
211 GRIN1 211125 x at 1.9859E-03 7.75E-06 4.69 3.49 3.14E-01
212 ATN1 1555754 s at 1.9859E-03 7.78E-06 4.68 3.48 2.64E-01
213 ARRB1 218832 x at 1.9859E-03 7.79E-06 -4.68 3.48 -4.04E-01
214 DPYSL2 200762 at 1.9859E-03 7.80E-06 -4.68 3.48 -7.14E-01
215 SYNCRIP 217834 s at 1.9859E-03 7.82E-06 -4.68 3.48 -5.29E-01
216 APOD 201525 at 1.9859E-03 7.85E-06 -4.68 3.48 -1.39E+00
217 SPRED1 226837 at 2.0023E-03 7.95E-06 -4.68 3.46 -7.07E-01
218 PP 1 K 244011 at 2.0039E-03 8.00E-06 4.68 3.46 2.71 E-01
219 NCKIPSD 216114 at 2.0039E-03 8.05E-06 4.68 3.45 2.76E-01
220 FCGR2C 210992 x at 2.0039E-03 8.09E-06 -4.67 3.45 -9.53E-01
221 PAPSS2 203059 s at 2.0039E-03 8.10E-06 -4.67 3.45 -4.14E-01
222 ADA 9 202381_at 2.0046E-03 8.17E-06 -4.67 3.44 -7.10E-01
223 RAB7A 211961 s at 2.0046E-03 8.19E-06 -4.67 3.44 -6.44E-01
224 WIPI1 203827 at 2.0046E-03 8.22E-06 -4.67 3.43 -7.74E-01
225 FA 129A 217967 s at 2.0046E-03 8.25E-06 -4.67 3.43 -7.76E-01
226 CECR2 223729 at 2.0077E-03 8.31 E-06 4.67 3.42 2.33E-01
227 AR CX3 222444 at 2.0077E-03 8.38E-06 -4.67 3.41 -4.29E-01
228 FCGR3B///F 204006_s_at 2.0077E-03 8.41 E-06 -4.67 3.41 -1.43E+00 CGR3A
229 LLT3 1569652 at 2.0077E-03 8.41 E-06 4.67 3.41 5.00E-01
230 PFKFB2 226733 at 2.0080E-03 8.45E-06 -4.66 3.41 -3.77E-01
231 CREG1 201200 at 2.0106E-03 8.49E-06 -4.66 3.40 -6.80E-01
232 PUS7L 221025 x at 2.0138E-03 8.57E-06 4.66 3.39 2.96E-01
233 GTPBP8 221046 s at 2.0138E-03 8.58E-06 4.66 3.39 5.96E-01
234 RASAL1 233144 s at 2.0574E-03 8.81 E-06 4.65 3.37 2.25E-01
235 EPOR 396 f at 2.0772E-03 8.93E-06 -4.65 3.36 -3.43E-01
236 SRSF3 208672 s at 2.0920E-03 9.03E-06 4.65 3.35 3.20E-01
237 NUDT16 228341 at 2.0980E-03 9.09E-06 -4.65 3.34 -4.73E-01
238 PEA15 200787 s at 2.1006E-03 9.16E-06 -4.64 3.33 -9.92E-01
239 PTTG1 IP 200677 at 2.1006E-03 9.18E-06 -4.64 3.33 -5.47E-01
240 GAS5 224741 x at 2.1290E-03 9.40E-06 4.64 3.31 7.20E-01
241 PHF20 235389 at 2.1290E-03 9.41 E-06 4.64 3.31 7.45E-01
242 GZF1 225884 s at 2.1290E-03 9.46E-06 -4.64 3.30 -4.11 E-01
243 P14 160020 at 2.1290E-03 9.46E-06 -4.64 3.30 -4.35E-01
244 ZFYVE21 219929 s at 2.1430E-03 9.56E-06 -4.63 3.29 -4.22E-01
245 CNKSR3 227481 at 2.1489E-03 9.63E-06 -4.63 3.29 -4.90E-01
246 CALR 214315 x at 2.1536E-03 9.74E-06 -4.63 3.28 -7.32E-01
247 ZBTB47 226484 at 2.1536E-03 9.75E-06 -4.63 3.28 -3.83E-01
248 SURF4 222979 s at 2.1536E-03 9.77E-06 -4.63 3.28 -4.40E-01
249 C16orf62 203173 s at 2.1813E-03 9.93E-06 -4.62 3.26 -3.49E-01
250 DAPK3 203890 s at 2.1974E-03 1.00E-05 -4.62 3.25 -3.35E-01
251 NAGA 1555041 a at 2.2693E-03 1.04E-05 -4.61 3.21 -7.22E-01
252 P11 235908 at 2.2693E-03 1.05E-05 4.61 3.21 2.60E-01
253 Y01 B 212365 at 2.2693E-03 1.05E-05 -4.61 3.21 -4.27E-01
254 226542 at 2.2693E-03 1.06E-05 -4.61 3.20 -3.49E-01
Wo. Gene* Probe ID" Adj. p value P value f B Log FC
255 P4HB 1564494 s at 2.2693E-03 1.07E-05 -4.61 3.20 -1.24E+00
256 PICALM 215236 s at 2.2693E-03 1.07E-05 -4.61 3.19 -9.40E-01
257 ICMT 201611 s at 2.2693E-03 1.07E-05 -4.61 3.19 -5.76E-01
258 CD3D 213539 at 2.2693E-03 1.07E-05 4.61 3.19 5.79E-01
259 TMEM176B 220532 s at 2.2758E-03 1.08E-05 -4.60 3.19 -9.49E-01
260 CREB5 229228 at 2.2792E-03 1.09E-05 -4.60 3.18 -3.16E-01
261 LOC100131 1558152_at 2.2792E-03 1.09E-05 -4.60 3.18 -3.03E-01 262
262 TSHZ3 223393 s at 2.2792E-03 1.09E-05 -4.60 3.17 -6.14E-01
263 RBM9 213901 x at 2.3212E-03 1.12E-05 -4.60 3.15 -4.91 E-01
264 CMKLR1 229121 at 2.3216E-03 1.12E-05 -4.59 3.15 -7.77E-01
265 TMEM176A 218345 at 2.3380E-03 1.13E-05 -4.59 3.14 -7.21 E-01
266 FGFR1 210973 s at 2.3397E-03 1.14E-05 -4.59 3.14 -3.68E-01
267 LTBR 203005 at 2.3491 E-03 1.15E-05 -4.59 3.13 -5.38E-01
268 SESN2 223196 s at 2.3494E-03 1.15E-05 -4.59 3.13 -3.96E-01
269 1569009 s at 2.3503E-03 1.16E-05 4.59 3.12 2.30E-01
270 HRH1 205580 s at 2.3651 E-03 1.17E-05 -4.58 3.11 -4.56E-01
271 CTNS 204925 at 2.3702E-03 1.17E-05 -4.58 3.11 -5.95E-01
272 CRELD2 218358 at 2.3783E-03 1.18E-05 -4.58 3.10 -4.47E-01
273 228951 at 2.3877E-03 1.19E-05 -4.58 3.09 -4.44E-01
274 C20orf3 206656 s at 2.4498E-03 1.23E-05 -4.57 3.07 -4.19E-01
275 COL6A5 1553835 a at 2.4562 E-03 1.24E-05 -4.57 3.06 -1.10E+00
276 EPHX1 202017 at 2.4715E-03 1.25E-05 -4.57 3.05 -1.04E+00
277 MCAM 209087 x at 2.4912E-03 1.26E-05 -4.57 3.04 -6.68E-01
278 PPAP2B 212230 at 2.4912E-03 1.27E-05 -4.56 3.04 -5.93E-01
279 SETD8 225118 at 2.5019E-03 1.28E-05 -4.56 3.03 -2.84E-01
280 APEX2 204408 at 2.5021 E-03 1.29E-05 -4.56 3.02 -4.10E-01
281 CALD1 201617 x at 2.5021 E-03 1.29E-05 -4.56 3.02 -9.37E-01
282 232535_at 2.5021E-03 1.30E-05 4.56 3.02 3.1 1 E-01
283 244798 at 2.5021 E-03 1.30E-05 4.56 3.02 1.01E+00
284 APP 200602 at 2.5021 E-03 1.30E-05 -4.56 3.01 -7.26E-01
285 CSDA 201160 s at 2.5021 E-03 1.30E-05 -4.56 3.01 -4.04E-01
286 CD44 204490 s at 2.5021 E-03 1.31 E-05 -4.56 3.01 -6.26E-01
287 SOD2 221477 s at 2.5037E-03 1.31 E-05 -4.56 3.01 -8.09E-01
288 EPHB2 211165 x at 2.5053E-03 1.32E-05 -4.55 3.00 -3.72E-01
289 ZCCHC10 1559399 s at 2.5053E-03 1.32E-05 4.55 3.00 8.39E-01
290 PSMD1 201198 s at 2.5096E-03 1.34E-05 -4.55 2.99 -8.38E-01
291 JMJD6 212723 at 2.5096E-03 1.34E-05 -4.55 2.99 -3.32E-01
292 HDLBP 200643 at 2.5096E-03 1.34E-05 -4.55 2.98 -6.95E-01
293 BTG1 1559975 at 2.5096E-03 1.34E-05 4.55 2.98 3.22E-01
294 RPN2 208689 s at 2.5129E-03 1.35E-05 -4.55 2.98 -8.82E-01
295 CPVL 208146 s at 2.5182E-03 1.36E-05 -4.55 2.97 -8.09E-01
296 1567140 at 2.5182E-03 1.37E-05 4.55 2.97 1.81 E-01
297 FNTA 230808 at 2.5182E-03 1.37E-05 4.55 2.97 2.32E-01
298 C4B///C4A 208451 s at 2.5196E-03 1.38E-05 -4.54 2.96 -1.10E+00
299 SLC39A8 219869 s at 2.5196E-03 1.38E-05 -4.54 2.96 -1.22E+00
300 237887 at 2.5390E-03 1.40E-05 4.54 2.95 2.90E-01
301 234508 at 2.5390E-03 1.40E-05 4.54 2.95 1.72E-01
302 DSE 218854 at 2.5643E-03 1.42E-05 -4.54 2.94 -5.44E-01
303 ANUBL1 223624 at 2.5689E-03 1.42E-05 4.54 2.93 2.50E-01
304 LILRB1 211336 x at 2.5793E-03 1.45E-05 -4.53 2.92 -8.51 E-01
305 PICALM 203134 at 2.5793E-03 1.45E-05 -4.53 2.92 -2.31 E-01
306 P4HB 200654 at 2.5793E-03 1.45E-05 -4.53 2.92 -6.53E-01
307 ZRANB3 224124 at 2.5793E-03 1.45E-05 4.53 2.91 2.02E-01
308 OPTN 202073 at 2.5793E-03 1.46E-05 -4.53 2.91 -5.24E-01
309 TNRC6C 1561041 at 2.5793E-03 1.46E-05 4.53 2.91 4.11 E-01
310 WDR62 1553125 x at 2.5848E-03 1.47E-05 4.53 2.90 2.07E-01
311 C1orf38 210785 s at 2.5848E-03 1.47E-05 -4.53 2.90 -9.40E-01
312 PPAP2B 212226 s at 2.6602E-03 1.52E-05 -4.52 2.87 -6.87E-01
313 MAPK14 210449 x at 2.7048E-03 1.55E-05 -4.51 2.86 -5.07E-01
314 CD99 201028 s at 2.7097E-03 1.56E-05 -4.51 2.85 -8.58E-01
315 AP3D1 210974 s at 2.7097E-03 1.56E-05 -4.51 2.85 -6.13E-01
316 CTNNA1 210844 x at 2.7097E-03 1.57E-05 -4.51 2.85 -5.22E-01
317 1562083 at 2.7098E-03 1.57E-05 4.51 2.84 1.35E-01
318 CFI 203854 at 2.7137E-03 1.58E-05 -4.51 2.84 -1.01 E+00
319 C3orf17 225281 at 2.7491 E-03 1.60E-05 4.51 2.82 3.19E-01
320 1563472 at 2.7541 E-03 1.61 E-05 4.50 2.82 2.04E-01
321 RELL1 226430_at 2.7671 E-03 1.62E-05 -4.50 2.81 -5.62E-01
322 CEBPB 212501 at 2.7703E-03 1.63E-05 -4.50 2.81 -6.67E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
323 RETSAT 218124 at 2.7703E-03 1.64E-05 -4.50 2.81 -3.61 E-01
324 ZBTB44 220243 at 2.8605E-03 1.70E-05 4.49 2.77 3.46E-01
325 RFESD 239142 at 2.8729E-03 1.71 E-05 4.49 2.77 5.37E-01
326 LDHA 200650 s at 2.8809E-03 1.72E-05 -4.49 2.76 -4.03E-01
327 CD44 1557905 s at 2.8836E-03 1.72E-05 -4.49 2.76 -7.56E-01
328 LOC100131 1556336_at 2.8893E-03 1.74E-05 4.49 2.75 5.08E-01
735///CCBL2
///RBMX
329 CEBPD 203973_s_at 2.8893E-03 1.74E-05 -4.49 2.75 -7.44E-01
330 RAB1A 208724 s at 2.9201 E-03 1.76E-05 -4.48 2.74 -3.42E-01
331 PCDHA3 211870 s at 2.9248E-03 1.77E-05 4.48 2.73 2.51 E-01
332 PTCSC 233111 at 2.9415E-03 1.79E-05 4.48 2.72 2.58E-01
333 240783 at 2.9415E-03 1.80 E-05 4.48 2.72 1.72E-01
334 CCNB1 IP1 217988 at 2.9415E-03 1.80E-05 4.48 2.72 7.22E-01
335 NCRNAOOO 1559293_x_at 2.9415E-03 1.81 E-05 4.48 2.72 1.76E-01 32
336 FAM13A 202972_s_at 2.9415E-03 1.81 E-05 -4.47 2.71 -4.20E-01
337 GAB1 226002 at 2.9415E-03 1.82E-05 -4.47 2.71 -3.84E-01
338 RPSAP19/// 213801_x_at 2.9415E-03 1.82E-05 4.47 2.71 2.98E-01 RPSAP9///R
PSAP58///R
PSA
339 ALS2CR8 219834 at 2.9529E-03 1.83E-05 4.47 2.70 3.23E-01
340 ADAMTS2 214454 at 2.9529E-03 1.84E-05 -4.47 2.70 -5.88E-01
341 IKZF5 220086 at 2.9681 E-03 1.85E-05 4.47 2.69 2.63E-01
342 RBMS1 225265 at 2.9681 E-03 1.86E-05 -4.47 2.69 -5.21 E-01
343 SERPINA1 202833 s at 2.9681 E-03 1.87E-05 -4.47 2.69 -1.51 E+00
344 FLVCR2 219316 s at 2.9681 E-03 1.87E-05 -4.47 2.69 -6.49E-01
345 LOC440288 23851 1 at 2.9775E-03 1.88 E-05 4.47 2.68 4.15E-01
346 COL6A5 1553834 at 2.9787E-03 1.88E-05 -4.47 2.68 -8.93E-01
347 RTN4 211509 s at 2.9931 E-03 1.91 E-05 -4.46 2.67 -3.32E-01
348 C9orf98 230976 at 2.9931 E-03 1.91 E-05 4.46 2.67 5.82E-01
349 GANAB 211934 x at 2.9971 E-03 1.91 E-05 -4.46 2.66 -7.40E-01
350 CTSB 227961 at 2.9971 E-03 1.92E-05 -4.46 2.66 -1.10E+00
351 LOC729806 217544 at 3.0259E-03 1.94E-05 4.46 2.65 6.55E-01
352 TFG 217839 at 3.0259E-03 1.95E-05 -4.46 2.65 -3.65E-01
353 TGFBI 201506 at 3.0259E-03 1.95E-05 -4.46 2.64 -7.37E-01
354 CALR 212953 x at 3.0405E-03 1.97E-05 -4.45 2.64 -3.61 E-01
355 PGK1 217356 s at 3.0424E-03 1.98E-05 -4.45 2.63 -1.06E+00
356 PDIA6 216640 s at 3.0527E-03 1.99E-05 -4.45 2.63 -6.45E-01
357 SIK2 223430 at 3.0527E-03 2.00E-05 -4.45 2.62 -3.63E-01
358 STAB1 204150 at 3.0527E-03 2.00E-05 -4.45 2.62 -9.02E-01
359 MCAM 210869 s at 3.0527E-03 2.01 E-05 -4.45 2.62 -5.54E-01
360 RXRA 202426 s at 3.0527E-03 2.01 E-05 -4.45 2.62 -2.84E-01
361 HMOX1 203665 at 3.0847E-03 2.04E-05 -4.45 2.61 -8.39E-01
362 L0C100130 236693_at 3.0869E-03 2.04E-05 4.44 2.60 1.99E-01 155
363 SP100 237426 at 3.0950E-03 2.05E-05 4.44 2.60 5.17E-01
364 KREMEN1 227250 at 3.1121 E-03 2.07E-05 -4.44 2.59 -4.03E-01
365 C13orf31 1553142 at 3.1259E-03 2.09E-05 -4.44 2.58 -2.82E-01
366 SHC1 214853 s at 3.1259E-03 2.09E-05 -4.44 2.58 -5.74E-01
367 KCTD12 212192 at 3.1381 E-03 2.11 E-05 -4.44 2.58 -4.68E-01
368 MBTPS2 206473 at 3.1502E-03 2.12 E-05 -4.44 2.57 -2.25E-01
369 RAB7A 211960 s at 3.1502E-03 2.13E-05 -4.43 2.57 -6.10E-01
370 HSPA6 117 at 3.1575E-03 2.14E-05 -4.43 2.56 -6.81 E-01
371 MRC1 L1///M 204438_at 3.1715E-03 2.15E-05 -4.43 2.56 -1.20E+00 RC1
372 HK1 200697 at 3.1917E-03 2.18 E-05 -4.43 2.55 -5.02E-01
373 CTSB 200838 at 3.1917E-03 2.18 E-05 -4.43 2.55 -1.04E+00
374 TMEM181 225127 at 3.2093E-03 2.20E-05 -4.43 2.54 -4.13E-01
375 RAB34 1555630 a at 3.2195E-03 2.21 E-05 -4.43 2.53 -8.15E-01
376 PFKFB4 228499 at 3.2338E-03 2.22E-05 -4.42 2.53 -4.84E-01
377 HS6ST1 225263 at 3.2436E-03 2.24E-05 -4.42 2.52 -4.23E-01
378 TUBB6 209191 at 3.2723E-03 2.26E-05 -4.42 2.51 -4.85E-01
379 IGHMBP2 31861 at 3.2760E-03 2.28E-05 -4.42 2.51 -2.07E-01
380 HERC2P7 232900 at 3.2760E-03 2.28E-05 4.42 2.50 1.90E-01
381 LAIR1 208071 s at 3.2760E-03 2.28E-05 -4.42 2.50 -5.98E-01
382 RPS20 214003 x at 3.2817E-03 2.29E-05 4.42 2.50 1.58E-01
383 NDRG1 200632 s at 3.2829E-03 2.30E-05 -4.41 2.50 -4.53 E-01
384 TLR2 204924 at 3.2829E-03 2.31 E-05 -4.41 2.49 -8.10E-01
No. Gene* Probe ID** Adj. p value P value ί B Log FC
385 F2D1 204452 s at 3.2996E-03 2.32E-05 -4.41 2.49 -1.92E-01
386 242453 at 3.3261 E-03 2.35E-05 4.41 2.48 2.47E-01
387 241904_at 3.3552E-03 2.37E-05 4.41 2.47 3.31 E-01
388 FCG 3B 204007 at 3.3568E-03 2.39E-05 -4.41 2.46 -1.02E+00
389 P2RY10 214615_at 3.3568E-03 2.39E-05 4.40 2.46 4.68E-01
390 TMEM37 L 227190_at 3.3568E-03 2.40E-05 -4.40 2.46 -4.79E-01
391 PDIA6 207668 x at 3.3568E-03 2.40E-05 -4.40 2.46 -4.15E-01
392 CITED2 209357 at 3.3684E-03 2.42E-05 -4.40 2.45 -7.40E-01
393 214083 at 3.3687E-03 2.43E-05 4.40 2.45 5.19E-01
394 ACTC1 205132 at 3.3687E-03 2.43E-05 -4.40 2.45 -4.76E-01
395 SLC04A1 219911 s at 3.3687E-03 2.44E-05 -4.40 2.44 -5.76E-01
396 PPP4R1 201594 s at 3.3687E-03 2.44E-05 -4.40 2.44 -2.88E-01
397 FN1 214701 s at 3.3774E-03 2.45E-05 -4.40 2.44 -5.03E-01
398 ILK 201234 at 3.3849E-03 2.46E-05 -4.40 2.43 -4.68E-01
399 TNFSF12- 209499_x_at 3.3948E-03 2.48E-05 -4.40 2.43 -9.07E-01 TNFSF13///
TNFSF12///
TNFSF13
400 ANPEP 202888_s_at 3.3948E-03 2.49E-05 -4.39 2.42 -9.74E-01
401 KIAA1143 227493_s_at 3.3948E-03 2.49E-05 4.39 2.42 5.16E-01
402 1558028 x at 3.3948E-03 2.50E-05 -4.39 2.42 -4.43E-01
403 PTGER2 206631 at 3.3948E-03 2.50E-05 -4.39 2.42 -5.85E-01
404 2NF136 206240 s at 3.4326E-03 2.54E-05 4.39 2.41 4.19E-01
405 TSPAN4 209263 x at 3.4414E-03 2.55E-05 -4.39 2.40 -5.31 E-01
406 RPL5 213080 x at 3.4567E-03 2.57E-05 4.39 2.40 2.10E-01
407 ZNF563 1552770 s at 3.4797E-03 2.59E-05 4.38 2.39 1.96E-01
408 PLIN3 202122 s at 3.4797E-03 2.60E-05 -4.38 2.39 -4.73E-01
409 SCARNA2 237137 at 3.4800E-03 2.61 E-05 4.38 2.38 5.82E-01
410 OLFML2B 213125 at 3.4800E-03 2.61 E-05 -4.38 2.38 -1.00E+00
411 TEAD4 41037 at 3.4886E-03 2.63E-05 -4.38 2.37 -2.90E-01
412 TTC32 226838 at 3.4886E-03 2.64E-05 4.38 2.37 4.74E-01
413 FNTB 1773 at 3.4886E-03 2.64E-05 -4.38 2.37 -2.39E-01
414 C1orf38 207571 x at 3.4886E-03 2.65E-05 -4.38 2.37 -7.6 E-01
415 LOC100133 209312_x_at 3.4886E-03 2.66E-05 -4.38 2.36 -7.40E-01
811///LOC10
0133661///Z
NF749///RN
ASE2///HLA-
DRB5///HLA
DRB4///HLA
DRB3///HLA
DRB2///HLA
-DRB1
416 CRK 202224 at 3.4886E-03 2.67E-05 -4.38 2.36 -4.93E-01
417 GAS5 224841 x at 3.4886E-03 2.67E-05 4.38 2.36 6.82E-01
418 CD44 212014 x at 3.4886E-03 2.68E-05 -4.38 2.36 -6.15E-01
419 LOC100133 223766_at 3.4886E-03 2.68E-05 4.38 2.36 3.14E-01 130
420 PHTF1 210191 s at 3.4886E-03 2.68E-05 -4.38 2.36 -3.37E-01
421 TNFAIP1 201207 at 3.4971 E-03 2.70E-05 -4.37 2.35 -5.57E-01
422 ERLIN1 202441 at 3.4971 E-03 2.70E-05 -4.37 2.35 -3.37E-01
423 RILPL1 226207 at 3.5155E-03 2.72E-05 -4.37 2.34 -3.69E-01
424 IFNAR1 225661 at 3.5212E-03 2.73E-05 -4.37 2.34 -5.71 E-01
425 GLUL 242281 at 3.5320E-03 2.75E-05 -4.37 2.34 -7.88E-01
426 LILRB4 210152 at 3.5702E-03 2.78E-05 -4.37 2.32 -1.12E+00
427 SGPL1 208381 s at 3.5853E-03 2.81 E-05 -4.36 2.32 -4.62E-01
428 CD14 201743 at 3.5853E-03 2.82E-05 -4.36 2.31 -1.01 E+00
429 LOC1518 1563445 x at 3.5853E-03 2.82E-05 -4.36 2.31 -4.68E-01
430 FBLIM1 1555480 a at 3.5853E-03 2.82E-05 -4.36 2.31 -4.29E-01
431 PICALM 212506 at 3.6379E-03 2.87E-05 -4.36 2.30 -4.91 E-01
432 NFE2L1 200759 x at 3.6379E-03 2.87E-05 -4.36 2.29 -4.35E-01
433 GOSR2 213206 at 3.6402E-03 2.89E-05 -4.36 2.29 -2.60E-01
434 G0SR2 213144 at 3.6402E-03 2.89E-05 -4.36 2.29 -2.93E-01
435 SDF2L1 218681 s at 3.6515E-03 2.91 E-05 -4.35 2.28 -5.05E-01
436 238265 x at 3.6515E-03 2.92E-05 4.35 2.28 2.41 E-01
437 F2D2 210220 at 3.6515E-03 2.92E-05 -4.35 2.28 -8.16E-01
438 DAB2 201279 s at 3.6519E-03 2.93E-05 -4.35 2.28 -8.23E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
439 NCRNA002 224915_x_at 3.6519E-03 2.93E-05 4.35 2.28 6.56E-01 75
440 234510 at 3.6519E-03 2.94E-05 4.35 2.27 1.32E-01
441 ALDH9A1 201612 at 3.6534E-03 2.95E-05 -4.35 2.27 -2.65E-01
442 MUC5AC 217187_at 3.6616E-03 2.97E-05 4.35 2.26 3.12E-01
443 SPIRE1 225018 at 3.6616E-03 2.98E-05 -4.35 2.26 -3.63E-01
444 MAFB 218559 s at 3.6616E-03 2.98E-05 -4.35 2.26 -6.98E-01
445 CARD9 220162 s at 3.6616E-03 2.98E-05 -4.35 2.26 -4.79E-01
446 RAB31 217763 s at 3.6940E-03 3.03E-05 -4.34 2.25 -8.50E-01
447 DCP2 244777 at 3.6940E-03 3.03E-05 4.34 2.25 5.71E-01
448 MMP19 204575 s at 3.6940E-03 3.03E-05 -4.34 2.25 -5.34E-01
449 DAB2 240873 x at 3.6940E-03 3.03E-05 -4.34 2.24 -2.80E-01
450 SNX33 227151 at 3.7155E-03 3.06E-05 -4.34 2.24 -3.27E-01
451 215180 at 3.7311 E-03 3.08E-05 4.34 2.23 2.56E-01
452 244216 at 3.7343E-03 3.09E-05 4.34 2.23 2.61E-01
453 POU5F1P4// 208286_x_at 3.7434E-03 3.10E-05 4.34 2.22 2.35E-01 /POU5F1P3/
//POU5F1B//
/POU5F1
454 TUBA1 B 201090_x at 3.7434E-03 3.11 E-05 -4.34 2.22 -4.41 E-01
455 FAM129B 223019 at 3.7434E-03 3.12E-05 -4.34 2.22 -5.18E-01
456 CSF1 R 203104 at 3.7527E-03 3.13E-05 -4.34 2.22 -1.03E+00
457 SNX19 1554986 a at 3.8439E-03 3.21 E-05 -4.33 2.19 -1.91 E-01
458 DTNBP1 223763 at 3.8439E-03 3.23E-05 4.33 2.19 3.83E-01
459 PLOD3 202185 at 3.8439E-03 3.23E-05 -4.33 2.19 -6.12E-01
460 LAMB1 211651 s at 3.8439E-03 3.24E-05 -4.33 2.19 -8.32E-01
461 S100A11 200660 at 3.8439E-03 3.24E-05 -4.33 2.18 -7.99E-01
462 DGCR8 219811 at 3.8904E-03 3.29E-05 4.32 2.17 2.73E-01
463 ANXA2P2 208816 x at 3.8904E-03 3.30E-05 -4.32 2.17 -4.35E-01
464 PDIA3 208612 at 3.8904E-03 3.30E-05 -4.32 2.17 -6.47E-01
465 235513 at 3.8978E-03 3.32E-05 4.32 2.16 4.19E-01
466 235772 at 3.9104E-03 3.33E-05 4.32 2.16 2.45E-01
467 RRAD 204802 at 3.9222E-03 3.35E-05 -4.32 2.15 -6.41 E-01
468 DCST2 242988 at 3.9274E-03 3.37E-05 4.32 2.15 1.84E-01
469 SNRPN 228370 at 3.9274E-03 3.37E-05 4.32 2.15 6.80E-01
470 ARCKS 225897 at 3.9551 E-03 3.40E-05 -4.32 2.14 -5.66E-01
471 BAT5 224756 s at 3.9732E-03 3.42E-05 -4.31 2.14 -5.35E-01
472 TNFSF12- 211495_x_at 3.9756E-03 3.43E-05 -4.31 2.13 -7.87E-01 TNFSF13///
TNFSF12///
TNFSF13
473 EIF4G2 200004 at 3.9786E-03 3.44E-05 -4.31 2.13 -2.80E-01
474 UBC///UBB// 211296_x_at 3.9839E-03 3.45E-05 -4.31 2.13 -3.95E-01 /RPS27A
475 NAIP 204860 s at 3.9887E-03 3.47E-05 -4.31 2.12 -7.67E-01
476 CD44 209835 x at 4.0059E-03 3.49E-05 -4.31 2.12 -5.73E-01
477 IGSF22 1553857 at 4.0059E-03 3.49E-05 4.31 2.12 2.87E-01
478 SEC63 201914 s at 4.0274E-03 3.52E-05 -4.31 2.11 -6.92E-01
479 TRIP6 209129 at 4.0572E-03 j 3.55E-05 -4.30 2.10 -5.52E-01
480 LOC100133 215193_x_at 4.0711 E-03 3.58E-05 -4.30 2.09 -7.10E-01
811///LOC10
0133661///Z
NF749///RN
ASE2///HLA-
DRB5///HLA
DRB4///HLA
DRB3///HLA
DRB2///HLA
-DRB1
481 C17orf48 223401 at 4.0711 E-03 3.59E-05 4.30 2.09 6.15E-01
482 227769 at 4.0711 E-03 3.59E-05 -4.30 2.09 -5.14E-01
483 RPS16 213890 x at 4.0711 E-03 3.60E-05 4.30 2.09 1.80E-01
484 ABCB7 209620 s at 4.1287E-03 3.66E-05 4.30 2.07 3.19E-01
485 LMNA 203411 s at 4.1287E-03 3.67E-05 -4.30 2.07 -5.85E-01
486 SGPL1 212322 at 4.1287 E-03 3.67E-05 -4.30 2.07 -7.15E-01
487 PGM3 210041 s at 4.1338E-03 3.68E-05 -4.29 2.07 -5.15E-01
488 PANK2 235130 at 4.1444E-03 3.70E-05 4.29 2.07 3.70E-01
No. Gene* Probe ID** Adj. p value P value t S Log FC
489 CD99L2 233825 s at 4.1779E-03 3.74E-05 -4.29 2.06 -4.27E-01
490 ZNF681 238962 at 4.1993E-03 3.76E-05 4.29 2.05 2.58E-01
491 STARD8 206868 at 4.2026E-03 3.78E-05 -4.29 2.05 -4.01 E-01
492 GNAQ 224862 at 4.2026E-03 3.78E-05 -4.29 2.05 -5.32E-01
493 KC F1 240430 at 4.2189E-03 3.80E-05 4.29 2.04 2.19E-01
494 RAD23B 201223 s at 4.2522E-03 3.84E-05 -4.28 2.03 -2.61 E-01
495 TYMS 217684 at 4.2522E-03 3.86E-05 4.28 2.03 1.80E-01
496 C1S 208747 s at 4.2522E-03 3.86E-05 -4.28 2.03 -5.83E-01
497 PAPSS2 203058 s at 4.2640E-03 3.88E-05 -4.28 2.02 -6.09E-01
498 TCTN2 239928 at 4.2640E-03 3.89E-05 4.28 2.02 2.02E-01
499 233335 at 4.2640E-03 3.89E-05 4.28 2.02 1.18E-01
500 OXNAD1 227686 at 4.2755E-03 3.91 E-05 4.28 2.01 6.72E-01
501 CHST15 203066 at 4.2755E-03 3.92E-05 -4.28 2.01 -7.11 E-01
502 TTC22 215106 at 4.2804E-03 3.93E-05 4.28 2.01 1.93E-01
503 TRADD 1729 at 4.3082E-03 3.96E-05 -4.28 2.00 -3.63E-01
504 KIF16B 219570 at 4.3297E-03 3.99E-05 -4.27 2.00 -4.25E-01
505 RAC1 1567458 s at 4.3388E-03 4.01 E-05 -4.27 1.99 -8.53E-01
506 E ILIN1 204163_at 4.4127E-03 4.09E-05 -4.27 1.97 -8.63E-01
507 PRKAR1A 200603 at 4.4127E-03 4.09E-05 -4.27 1.97 -3.85E-01
508 SIT1 205484_at 4.4281 E-03 4.11 E-05 4.27 1.97 3.88E-01
509 LE D1 229927 at 4.4427E-03 4.14E-05 4.26 1.96 2.05E-01
510 NAGLU 204360 s at 4.4427E-03 4.14E-05 -4.26 1.96 -4.55E-01
511 VSIG10L 238654 at 4.4774E-03 4.18E-05 -4.26 1.95 -3.16E-01
512 TUBA1C 211750 x at 4.4774E-03 4.19E-05 -4 26 1.95 -4.36E-01
513 FOLH1 217483 at 4.5304E-03 4.25E-05 4.26 1.94 1.66E-01
514 DNAJB11 223054 at 4.5366E-03 4.26E-05 -4.26 1.94 -6.14E-01
515 231552 at 4.5374E-03 4.27E-05 4.26 1.93 3.12E-01
516 SETD7 224928 at 4.5435E-03 4.29E-05 -4.25 1.93 -4.82E-01
517 NT5C3 223298 s at 4.5435E-03 4.30E-05 4.25 1.93 5.99E-01
518 RB S1 209868 s at 4.5435E-03 4.30E-05 -4.25 1.93 -9.38E-01
519 HIST1 H2AH 208583_x_at 4.5481 E-03 4.32E-05 4.25 1.92 5.73E-01
///HIST1 H2A
G///HIST1 H2
AIW//HIST1
H2AU//HIST
1 H2AJ///HIS
T1 H2AK///HI
ST1 H2AI
520 VKORC1 217949 s at 4.5605E-03 4.34E-05 -4.25 1.92 -6.92E-01
521 ZPBP2 231442 at 4.5972E-03 4.38E-05 4.25 1.91 1.41 E-01
522 NCRNA002 226227_x_at 4.6147E-03 4.41 E-05 4.25 1.91 6.14E-01 75
523 STK38 1553117 a at 4.6309E-03 4.43E-05 -4.25 1.90 -5.76E-01
524 ARPC2 213513 x at 4.6340E-03 4.44E-05 -4.25 1.90 -2.87E-01
525 NDNL2 226008 at 4.6443E-03 4.47E-05 4.24 1.89 2.55E-01
526 PTPN11 209895 at 4.6443E-03 4.48E-05 -4.24 1.89 -2.99E-01
527 LOC390595 232663 s at 4.6443E-03 4.48E-05 4.24 1.89 2.41E-01
528 RAB3GAP1 213530 at 4.6469E-03 4.50E-05 -4.24 1.89 -2.63E-01
529 SEL1 L 230265 at 4.6469E-03 4.50E-05 -4.24 1.89 -4.76E-01
530 ATP5I 209492 x at 4.6469E-03 4.51 E-05 4.24 1.88 5.75E-01
531 NEU1 208926 at 4.6469E-03 4.52E-05 -4.24 1.88 -7.06E-01
532 SEC23B 201583 s at 4.6469E-03 4.52E-05 -4.24 1.88 -7.21 E-01
533 LILRB1 207104 x at 4.6798E-03 4.56E-05 -4.24 1.88 -8.08E-01
534 TPI1 213011 s at 4.6813E-03 4.59E-05 -4.24 1.87 -5.59E-01
535 243388 at 4.6813E-03 4.59E-05 4.24 1.87 2.55E-01
536 DCD 1553946 at 4.6813E-03 4.60E-05 4.24 1.87 2.18E-01
537 PVRL2 225418 at 4.6813E-03 4.60E-05 -4.24 1.87 -4.14E-01
538 CD63 200663 at 4.6813E-03 4.61 E-05 -4.24 1.87 -4.24 E-01
539 SLC39A6 202089 s at 4.7291 E-03 4.67E-05 -4.23 1.85 -7.32E-01
540 RPL36 231658 x at 4.7291 E-03 4.68E-05 4.23 1.85 1.57E-01
541 FNDC3B 229865 at 4.7291 E-03 4.68E-05 -4.23 1.85 -4.76E-01
542 233920 at 4.7498E-03 4.71 E-05 4.23 1.85 2.48E-01
543 ALDH6A1 204290 s at 4.7679E-03 4.74E-05 -4.23 1.84 -6.35E-01
544 YWHAG 222985 at 4.7683E-03 4.75E-05 -4.23 1.84 -3.99E-01
545 PDU1 209208 at 4.7683E-03 4.75E-05 -4.23 1.84 -4.90E-01
546 CTSB 200839 s at 4.7953E-03 4.79E-05 -4.23 1.83 -6.67E-01
547 NRP2 219367 s at 4.8823E-03 4.88E-05 -4.22 1.81 -3.42E-01
548 EPHA4 238671 at 4.9116E-03 4.92E-05 4.22 1.81 1.87E-01
549 GGCX 205351 at 4.9343E-03 4.95E-05 -4.22 1.80 -3.89E-01
550 ADRA2B 208544 at 4.9573E-03 4.99E-05 4.22 1.79 3.05E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
551 242980 at 4.9573E-03 5.01 E-05 4.21 1.79 1.53E-01
552 QKI 212636 at 4.9573E-03 5.02E-05 -4.21 1.79 -5.47E-01
553 PDXK 202671 s at 4.9573E-03 5.03E-05 -4.21 1.79 -7.13E-01
554 242629 at 4.9573E-03 5.04E-05 4.21 1.79 1.44E-01
555 DUT 209932 s at 4.9573E-03 5.05E-05 4.21 1.78 3.55E-01
556 PPARA 223437 at 4.9573E-03 5.05E-05 -4.21 1.78 -4.56E-01
557 CFHR1///CF 215388_s_at 4.9573E-03 5.06E-05 -4.21 1.78 -6.16E-01 H
558 WDFY3 212602 at 4.9573E-03 5.06E-05 -4.21 1.78 -4.14E-01
559 MIA3 1569057 s at 4.9604E-03 5.07E-05 -4.21 1.78 -3.46E-01
560 CTBP2 210554 s at 4.9704E-03 5.09E-05 -4.21 1.78 -4.52E-01
561 234987 at 4.9767E-03 5.12 E-05 -4.21 1.77 -6.43E-01
562 PGAM1 200886 s at 4.9767E-03 5.13E-05 -4.21 1.77 -3.62E-01
563 GAS5 228238 at 4.9767E-03 5.13E-05 4.21 1.77 6.68E-01
564 LOC284648 231427 at 4.9767E-03 5.13E-05 4.21 1.77 2.13E-01
565 PDXK 222492 at 4.9810E-03 5.15E-05 -4.21 1.77 -3.86E-01
566 ZAK 223519 at 5.0014E-03 5.18E-05 -4.21 1.76 -5.46E-01
567 BLVRA 203771 s at 5.0014E-03 5.20E-05 -4.21 1.76 -8.30E-01
568 217521 at 5.0014E-03 5.20E-05 4.21 1.76 2.46E-01
569 USP40 225085 at 5.0032E-03 5.21 E-05 -4.20 1.75 -3.27E-01
570 C13orf31 228937 at 5.0032E-03 5.22E-05 -4.20 1.75 -6.51 E-01
571 STAB1 38487 at 5.0120E-03 5.23E-05 -4.20 1.75 -8.55E-01
572 TNFRSF1A 207643_s_at 5.0214E-03 5.25E-05 -4.20 1.75 -5.87E-01
573 HSP90B1 200599 s at 5.0348E-03 5.28E-05 -4.20 1.74 -4.74E-01
574 FRMD4A 225167 at 5.0365E-03 5.30E-05 -4.20 1.74 -6.87E-01
575 HSPA8 210338 s at 5.0365E-03 5.30E-05 -4.20 1.74 - .03E+00
576 OTUD4 238848 at 5.0365E-03 5.31 E-05 -4.20 1.74 -4.25E-01
577 NEDD4L 237498 at 5.0401 E-03 5.32E-05 4.20 1.74 1.75E-01
578 GBAP1///GB 209093_s_at 5.0401 E-03 5.33E-05 -4.20 1.73 -5.46E-01 A
579 DAB2 210757 x at 5.0401 E-03 5.34E-05 -4.20 1.73 -7.10E-01
580 TUBA1C 209251 x at 5.0516E-03 5.36E-05 -4.20 1.73 -4.13E-01
581 TTC37 1554029 a at 5.0735E-03 5.39E-05 -4.20 1.72 -2.43E-01
582 FCGR2A 203561 at 5.0962E-03 5.42E-05 -4.19 1.72 -1.04E+00
583 LOC100131 244029_at 5.1050E-03 5.45E-05 4.19 1.71 5.09E-01 043
584 KIAA0146 228325 at 5.1050E-03 5.47E-05 -4.19 1.71 -6.72E-01
585 AP1S1 205196 s at 5.1050E-03 5.48E-05 -4.19 1.71 -3.48E-01
586 1561942 x at 5.1050E-03 5.48E-05 4.19 1.71 2.58E-01
587 NRP1 210510 s at 5.1050E-03 5.48E-05 -4.19 1.71 -5.01 E-01
588 DHDPSL 239093 at 5. 050E-03 5.49E-05 4.19 1.71 1.92E-01
589 G PPA 218070 s at 5.1117E-03 5.51 E-05 -4.19 1.70 -3.61 E-01
590 PTPN7 1554860 at 5.1117E-03 5.52E-05 4.19 1.70 2.76E-01
591 SPRED1 244439 at 5.1231 E-03 5.54E-05 -4.19 1.70 -5.03E-01
592 ZNF410 209944 at 5.1231 E-03 5.55E-05 4.19 1.70 3.46E-01
593 GLT25D1 218473 s at 5.1287E-03 5.57E-05 -4.19 1.69 -4.73E-01
594 EPAS1 200878 at 5.1287E-03 5.58E-05 -4.19 1.69 -7.35E-01
595 NF1 212678 at 5.1287E-03 5.58E-05 -4.19 1.69 -2.90E-01
596 ZNF100 238791 at 5.1287E-03 5.59E-05 4.19 1.69 2.42E-01
597 237965 at 5.1615E-03 5.64E-05 4.18 1.68 2.43E-01
598 PADI1 223739 at 5.1695E-03 5.65E-05 4.18 1.68 1.84E-01
599 LM04 209205 s at 5.1722E-03 5.67E-05 -4.18 1.68 -3.52E-01
600 SLC39A1 217778 at 5.1722E-03 5.68E-05 -4. 8 1.68 -2.51 E-01
601 1563188 at 5.1722E-03 5.69E-05 4.18 1.68 1.39E-01
602 239287 at 5.1858E-03 5.72E-05 4.18 1.67 8.99E-01
603 DUSP3 201537 s at 5.1858E-03 5.73E-05 -4.18 1.67 -5.59E-01
604 LA B3 209270 at 5.1858E-03 5.73E-05 -4.18 1.67 -3.68E-01
605 236379 at 5.1905E-03 5.74E-05 4.18 1.67 6.85E-01
606 CCDC3 223316 at 5.2128E-03 5.80E-05 -4.18 1.66 -6.55E-01
607 IL13RA1 211612 s at 5.2128E-03 5.80E-05 -4.18 1.66 -8.14E-01
608 DPP9 231957 s at 5.2128E-03 5.80E-05 -4.18 1.66 -2.17E-01
609 APLP2 214875 x at 5.2128E-03 5.81 E-05 -4.18 1.66 -6.09E-01
610 ATXN3 216657 at 5.2128E-03 5.82E-05 4.18 1.66 1.73E-01
611 PDXK 218019 s at 5.2135E-03 5.83E-05 -4.18 1.65 -4.44E-01
612 CTSC 225647 s at 5.2758E-03 5.91 E-05 -4.17 1.64 -7.36E-01
613 RPS4X 213347 x at 5.2758E-03 5.92E-05 4.17 1.64 1.86E-01
614 236901 at 5.2758E-03 5.92E-05 -4.17 1.64 -7.89E-01
615 MCAM 209086 x at 5.2795E-03 5.94E-05 -4.17 1.64 -3.21 E-01
616 RRAS 212647 at 5.2847E-03 5.95E-05 -4.17 1.63 -5.43E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
617 CD99 201029 s at 5.2847E-03 5.98E-05 -4.17 1.63 -4.89E-01
618 COMT 208817 at 5.2847E-03 5.98E-05 -4.17 1.63 -7.00E-01
619 DELR2 200699 at 5.2847E-03 5.98E-05 -4.17 1.63 -5.94E-01
620 FAHD1 227960 s at 5.3065E-03 6.03E-05 -4.17 1.62 -4.82E-01
621 ZNF101 1552634 a at 5.3065E-03 6.03E-05 4.17 1.62 7.36E-01
622 TULP3 221964 at 5.3151 E-03 6.06E-05 -4.17 1.62 -2.22E-01
623 COBLL1 211032 at 5.3151 E-03 6.06E-05 4.17 1.62 1.82E-01
624 PLD1 215723 s at 5.3344E-03 6.10E-05 -4.16 1.61 -3.98E-01
625 SPPL2B 225248 at 5.3344E-03 6.11 E-05 4.16 1.61 2.61 E-01
626 1554224 at 5.3344E-03 6.11 E-05 4.16 1.61 2.80E-01
627 RC3H1 225893 at 5.3602E-03 6.15E-05 4.16 1.61 3.21 E-01
628 243104 at 5.3721 E-03 6.17E-05 4.16 1.60 2.17E-01
629 SUCNR1 223939 at 5.3864E-03 6.20E-05 -4.16 1.60 -1.05E+00
630 221648 s at 5.3949E-03 6.24E-05 4.16 1.59 6.76E-01
631 229830 at 5.3949E-03 6.24E-05 -4.16 1.59 -4.95E-01
632 FEZ2 202305 s at 5.3949E-03 6.25E-05 -4.16 1.59 -4.81 E-01
633 MLEC 200616 s at 5.3949E-03 6.27E-05 -4.16 1.59 -5.20E-01
634 GAS7 211067 s at 5.3949E-03 6.27E-05 -4.16 1.59 -4.59E-01
635 C2orf18 225695_at 5.3949E-03 6.28E-05 -4.16 1.59 -4.89E-01
636 UBE3A 213128 s at 5.3949E-03 6.28E-05 -4.16 1.59 -3.68E-01
637 SLC35C1 222647_at 5.3949E-03 6.29E-05 -4.16 1.58 -2.89E-01
638 AQP1 207542_s_at 5.3949E-03 6.30E-05 -4.15 1.58 -6.11 E-01
639 NSD1 235760 at 5.3949E-03 6.31 E-05 4.15 1.58 3.07E-01
640 CD59 212463_at 5.3949E-03 6.32E-05 -4.15 1.58 -4.81 E-01
641 IRAKI BP1 238599_at 5.3949E-03 6.32E-05 4.15 1.58 5.07E-01
642 KIAA1432 223826 s at 5.4006E-03 6.35E-05 -4.15 1.58 -1.63E-01
643 TRI 27 210541 s at 5.4006 E-03 6.35E-05 -4.15 1.58 -7.34E-01
644 RAB3GAP1 239527 at 5.4109E-03 6.37E-05 4.15 1.57 1.63E-01
645 TM9SF1 209150 s at 5.4170E-03 6.39E-05 -4.15 1.57 -5.31 E-01
646 SORD 201562 s at 5.4170E-03 6.40E-05 -4.15 1.57 -5.20E-01
647 CD59 200984 s at 5.4201 E-03 6.41 E-05 -4.15 1.57 -6.23E-01
648 CPNE8 241706 at 5.4201 E-03 6.43E-05 -4.15 1.56 -3.25E-01
649 LOC389199 1554809 at 5.4201 E-03 6.43E-05 4.15 1.56 2.20E-01
650 FAM127A 201828 x at 5.4361 E-03 6.46E-05 -4.15 1.56 -6.15E-01
651 MAOB 204041 at 5.4937E-03 6.54E-05 -4.14 1.55 -5.18E-01
652 ZNF345 207236 at 5.4937E-03 6.57E-05 4.14 1.54 2.83E-01
653 230599 at 5.4937E-03 6.57E-05 4.14 1.54 6.03E-01
654 H2AFY 214500 at 5.4937E-03 6.57E-05 -4.14 1.54 -8.36E-01
655 CYB561 209163 at 5.4985E-03 6.60E-05 -4.14 1.54 -4.57E-01
656 PDAP1 202290 at 5.4985E-03 6.60E-05 -4.14 1.54 -5.92E-01
657 MTERFD2 214364 at 5.4985E-03 6.62E-05 4.14 1.54 4.71 E-01
658 238106 at 5.4985E-03 6.63E-05 4.14 1.54 2.74E-01
659 ARRB2 203388 at 5.4985E-03 6.63E-05 -4.14 1.54 -6.30E-01
660 CDC42BPB 217849 s at 5.5188E-03 6.67E-05 -4.14 1.53 -5.08E-01
661 ZNRF2 229188 s at 5.5188E-03 6.67E-05 4.14 1.53 1.81 E-01
662 1563297 s at 5.5381 E-03 6.71 E-05 4.14 1.53 1.34E-01
663 HIST1 H1 D 214537 at 5.5381 E-03 6.72E-05 4.14 1.53 6.34E-01
664 RRAD 204803 s at 5.5424E-03 6.73E-05 -4.14 1.52 -5.58E-01
665 CSPG5 39966 at 5.5424E-03 6.75E-05 4.14 1.52 2.14E-01
666 ZNF384 220616 at 5.5424E-03 6.76E-05 4.14 1.52 2.58E-01
667 TRIM47 225868 at 5.5424E-03 6.78E-05 -4.14 1.52 -5.18E-01
668 SLC24A6 218749 s at 5.5424E-03 6.79E-05 -4.13 1.51 -4.74E-01
669 IL15RA 207375 s at 5.5424E-03 6.80E-05 -4.13 1.51 -5.85E-01
670 FKBP2 203391 at 5.5424E-03 6.80E-05 -4.13 1.51 -4.68E-01
671 CHP 214665 s at 5.5424E-03 6.81 E-05 -4.13 1.51 -5.96E-01
672 RP9 227849 at 5.5424E-03 6.82E-05 4.13 1.51 1.91 E-01
673 FLII 212025 s at 5.5424E-03 6.82E-05 -4.13 1.51 -7.06E-01
674 CD81 200675 at 5.5424E-03 6.83E-05 -4.13 1.51 -6.50E-01
675 HSP90B1 200598 s at 5.5461 E-03 6.85E-05 -4.13 1.51 -6.94E-01
676 HLA-DRB6 217362 x at 5.5461 E-03 6.86E-05 -4.13 1.51 -5.33E-01
677 AP3D1 206592 s at 5.5531 E-03 6.88E-05 -4.13 1.50 -4.43E-01
678 PDE11A 221110 x at 5.5531 E-03 6.89E-05 4.13 1.50 1.64E-01
679 HSP90AA1 210211 s at 5.5633E-03 6.92E-05 -4.13 1.50 -3.20E-01
680 COPS7A 209029 at 5.5633E-03 6.92E-05 -4.13 1.50 -3.88E-01
681 KDSR 229850 at 5.5674E-03 6.93E-05 -4.13 1.50 -4.71 E-01
682 ARX 231020 at 5.6116E-03 7.01 E-05 4.13 1.49 2.88E-01
683 CISH 223961 s at 5.6116E-03 7.01 E-05 -4.13 1.49 -6.93E-01
684 ZSCAN16 219676 at 5.6116E-03 7.03E-05 4.13 1.48 4.39E-01
685 235295 at 5.6116E-03 7.05E-05 -4.13 1.48 -2.64E-01
No. Gene* Probe ID** Adj. p value P value f S Log FC
686 Sep-02 1554747 a at 5.61 16E-03 7.05E-05 -4.13 1.48 -5.56E-01
687 HSPH1 208744 x at 5.61 16E-03 7.05E-05 -4.12 1.48 -6.35E-01
688 CD163 203645 s at 5.61 16E-03 7.07E-05 -4.12 1.48 -1.35E+00
689 FCRLB 238452 at 5.6116E-03 7.07E-05 -4.12 1.48 -4.01 E-01
690 237954 x at 5.6133E-03 7.08E-05 4.12 1.48 1.53E-01
691 KIAA0368 212428 at 5.6133E-03 7.09E-05 -4.12 1.48 -7.47E-01
692 SP100 202863 at 5.6141 E-03 7.11 E-05 4.12 1.47 3.09E-01
693 EDE 3 220926 s at 5.6167E-03 7.12E-05 -4.12 1.47 -3.63E-01
694 AGBL2 220390 at 5.6328E-03 7.16E-05 4.12 1.47 1.93E-01
695 236109 at 5.6328E-03 7.16E-05 4.12 1.47 3.69E-01
696 PDGFRB 202273 at 5.6396E-03 7.18E-05 -4.12 1.46 -5.80E-01
697 1564389 at 5.6396E-03 7.19E-05 4.12 1.46 1.64E-01
698 236301 at 5.6543E-03 7.23E-05 4.12 1.46 4.21E-01
699 CYP2D6 217468 at 5.6543E-03 7.23E-05 4.12 1.46 2.60E-01
700 DYNLRB2 2381 16 at 5.6590E-03 7.25E-05 4.12 1.46 4.00E-01
701 CTNNA1 200765 x at 5.6649E-03 7.26E-05 -4.12 1.45 -5.07E-01
702 CTSC 201487 at 5.6696E-03 7.28E-05 -4.12 1.45 -4.83E-01
703 RPS7 213941 x at 5.6696E-03 7.29E-05 4.12 1.45 2.28E-01
704 RABGAP1 L 213982 s at 5.6796E-03 7.32E-05 4.12 1.45 4.50E-01
705 KPNA1 213741 s at 5.6796E-03 7.32E-05 -4.11 1.45 -4.23E-01
706 SEL1 L 202061_s_at 5.6898E-03 7.35E-05 -4.1 1 1.44 -3.97E-01
707 TRA 2 202369 s at 5.6931 E-03 7.36E-05 -4.11 1.44 -7.21 E-01
708 CD163 215049_x at 5.7083E-03 7.39E-05 -4.11 1.44 -1.32E+00
709 GYLTL1B 227829 at 5.7170E-03 7.44E-05 4.1 1 1.43 2.49E-01
710 CARD8 228641 at 5.7170E-03 7.45E-05 4.1 1 1.43 5.80E-01
71 1 DOCK5 230263 s at 5.7170E-03 7.46E-05 -4.11 1.43 -5.03E-01
712 PS C3 201267 s at 5.7170E-03 7.46E-05 -4.11 1.43 -8.38E-01
713 SLC35B1 202433 at 5.7170E-03 7.47E-05 -4.11 1.43 -4.21 E-01
714 DH1 235374 at 5.7170E-03 7.47E-05 4.1 1 1.43 4.98E-01
715 A PD2 212360 at 5.7179E-03 7.48E-05 -4.11 1.43 -4.68E-01
716 PVRL2 232079 s at 5.7307E-03 7.50E-05 -4.1 1 1.42 -4.56E-01
717 228049 x at 5.7355E-03 7.52E-05 4.1 1 1.42 7.30E-01
718 BRCC3 221196 x at 5.7682E-03 7.57E-05 -4.11 1.42 -4.26E-01
719 ITPRIPL2 227792 at 5.7750E-03 7.61 E-05 -4.10 1.41 -6.31 E-01
720 PIGT 217770 at 5.7750E-03 7.61 E-05 -4.10 1.41 -3.44E-01
721 ST N1 217714 x at 5.7750E-03 7.62E-05 4.10 1.41 2.74E-01
722 KCND3 213832 at 5.8062E-03 7.68E-05 -4.10 1.40 -4.67E-01
723 FOLR1 211074 at 5.8062E-03 7.69E-05 4.10 1.40 6.15E-01
724 CCL18 32128 at 5.8062E-03 7.70E-05 -4.10 1.40 -1.20E+00
725 TPI1 200822 x at 5.8062E-03 7.70E-05 -4.10 1.40 -5.13E-01
726 ERTK 211913 s at 5.8173E-03 7.72E-05 -4.10 1.40 -4.55E-01
727 PR T5 217786 at 5.8431 E-03 7.77E-05 -4.10 1.39 -6.47E-01
728 234417 at 5.8721 E-03 7.82E-05 4.10 1.39 2.01 E-01
729 TSHZ3 223392 s at 5.8863E-03 7.85E-05 -4.10 1.38 -4.75E-01
730 TRF1 244763 at 5.9071 E-03 7.89E-05 4.10 1.38 2.41 E-01
731 PPARGC1A 1569141 a at 5.9158E-03 7.91 E-05 4.09 1.38 1.98E-01
732 NDUFA2 209223 at 5.9158E-03 7.92E-05 4.09 1.38 2.81 E-01
733 PPARG 208510 s at 5.9441 E-03 7.97E-05 -4.09 1.37 -5.67E-01
734 S100A11 P1/ 208540_x_at 5.9491 E-03 7.99E-05 -4.09 1.37 -6.26E-01 //S100A11
735 RCN1 201063 at 5.9571 E-03 8.02E-05 -4.09 1.36 -4.71 E-01
736 CSDA 201161 s at 5.9571 E-03 8.03E-05 -4.09 1.36 -5.62E-01
737 GNS 212335 at 5.9571 E-03 8.03E-05 -4.09 1.36 -8.26E-01
738 YIF1B 226437 at 5.9594E-03 8.05E-05 -4.09 1.36 -4.43E-01
739 SEC61A1 222385 x at 5.9594E-03 8.06E-05 -4.09 1.36 -8.03E-01
740 HCK 208018_s_at 5.9594E-03 8.07E-05 -4.09 1.36 -7.96E-01
741 GNAQ 224861 at 6.0067E-03 8.17E-05 -4.09 1.35 -4.76E-01
742 GFPT1 202721 s at 6.0067E-03 8.20E-05 -4.08 1.34 -3.69E-01
743 CCL23 210549 s at 6.0067E-03 8.20E-05 -4.08 1.34 -1.34E+00
744 215796_at 6.0067E-03 8.21 E-05 4.08 1.34 5.67E-01
745 CCL23 210548_at 6.0067E-03 8.22E-05 -4.08 1.34 -1.45E+00
746 CTSZ 210042 s at 6.0067E-03 8.23E-05 -4.08 1.34 -9.00E-01
747 CSF2RA 21 1287 x at 6.0067E-03 8.23E-05 -4.08 1.34 -4.73E-01
748 CLCC1 207855 s at 6.0067E-03 8.25E-05 -4.08 1.34 -2.75E-01
749 NSFL1C 217831 s at 6.0067E-03 8.25E-05 -4.08 1.34 -4.55E-01
750 CCDC96 238682_at 6.0067E-03 8.25E-05 -4.08 1.34 -1.67E-01
751 SNORD104 228879_at 6.0067E-03 8.25E-05 4.08 1.34 5.58E-01
752 RANBP9 216125_s_at 6.0067E-03 8.26E-05 -4.08 1.34 -4.28E-01
753 TPD52L2 201379_s_at 6.0261 E-03 8.30E-05 -4.08 1.33 -5.64E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
754 ZC3H6 227809 at 6.0314E-03 8.32E-05 4.08 1.33 3.74E-01
755 RAB31 217762 s at 6.0399E-03 8.34E-05 -4.08 1.33 -7.68E-01
756 235072 s at 6.0679E-03 8.39E-05 -4.08 1.32 -4.79E-01
757 HSPA5 230031 at 6.0727E-03 8.41 E-05 -4.08 1.32 -4.39E-01
758 SCARNA17 240830 at 6.0794E-03 8.43E-05 4.08 1.32 5.94E-01
759 LOC253962 1559061 at 6.1036E-03 8.47E-05 4.08 1.32 2.57E-01
760 PLAG1 205372 at 6.1143E-03 8.52E-05 4.07 1.31 3.74E-01
761 TUBA1B 212639 x at 6.1143E-03 8.52E-05 -4.07 1.31 -4.67E-01
762 TI P2 231579 s at 6.1143E-03 8.54E-05 -4.07 1.31 -8.36E-01
763 GADD45B 209305 s at 6.1143E-03 8.55E-05 -4.07 1.31 -5.60E-01
764 217615 at 6.1143E-03 8.55E-05 4.07 1.31 2.32E-01
765 LOC100128 1562765_at 6.1143E-03 8.55E-05 4.07 1.31 2.28E-01 025
766 NAGA 202943 s at 6.1341 E-03 8.59E-05 -4.07 1.30 -6.42E-01
767 CD69 209795 at 6.1816E-03 8.67E-05 4.07 1.29 6.70E-01
768 PGD 201118_at 6.1965E-03 8.71 E-05 -4.07 1.29 -1.02E+00
769 CCT6A 201327 s at 6.1965E-03 8.72E-05 -4.07 1.29 -3.31 E-01
770 ACOT7 208002 s at 6.1965E-03 8.73E-05 -4.07 1.29 -5.90E-01
771 BCL2L2 209311 at 6.2043E-03 8.75E-05 -4.07 1.29 -4.54E-01
772 LRRC59 222231 s at 6.2111 E-03 8.77E-05 -4.07 1.28 -5.71 E-01
773 PMS2L1 214526 x at 6.2329E-03 8.82E-05 4.07 1.28 4.33E-01
774 ZCRB1 225394 s at 6.2329E-03 8.82E-05 4.07 1.28 4.09E-01
775 NBR1 201384 s at 6.2355E-03 8.84E-05 -4.06 1.28 -5.26E-01
776 HIST2H4B/// 205967_at 6.2355E-03 8.85E-05 4.06 1.28 7.42E-01 HIST4H4///H
IST2H4A///H
IST1 H4U//H
IST1 H4E///H
IST1 H4B///H
IST1 H4HWH
IST1H4C///H
IST1 H4J///HI
ST1 H4K///HI
ST1 H4F///HI
ST1 H4D///HI
ST1 H4A///HI
ST1 H4I
777 ASTE1 221135 s at 6.2355E-03 8.87E-05 4.06 1.27 3.39E-01
778 ATG7 218673 s at 6.2355E-03 8.87E-05 -4.06 1.27 -5.80E-01
779 RDH1 1 217776 at 6.2362E-03 8.89E-05 -4.06 1.27 -2.46E-01
780 CCDC61 228475 at 6.2362E-03 8.90E-05 4.06 1.27 2.04E-01
781 AP1B1 205423 at 6.2750E-03 8.98E-05 -4.06 1.26 -3.67E-01
782 APK1 212271 at 6.2750E-03 8.98E-05 -4.06 1.26 -6.85E-01
783 HIST1H2AH 214542_x_at 6.2750E-03 9.01 E-05 4.06 1.26 5.23E-01 ///HIST1 H2A
G///HIST1 H2
A ///HIST1
H2AL///HIST
1 H2AJ///HIS
T1H2AK///HI
ST1 H2AI
784 TPP1 200743 s at 6.2750E-03 9.02E-05 -4.06 1.26 -6.83E-01
785 IGFBP2 202718 at 6.2750E-03 9.02E-05 -4.06 1.26 -8.59E-01
786 CDK2AP1 201938 at 6.2750E-03 9.02E-05 -4.06 1.26 -4.05E-01
787 SKIV2L2 227447 at 6.2879E-03 9.06E-05 4.06 1.25 3.49 E-01
788 OLF 4 212768 s at 6.2879E-03 9.07E-05 4.06 1.25 1.38E-01
789 GORASP2 207812 s at 6.2879E-03 9.07E-05 -4.06 1.25 -3.61 E-01
790 T E 214 217899 at 6.2879E-03 9.10E-05 -4.06 1.25 -5.14E-01
791 GNPTG 224887 at 6.2879E-03 9.10E-05 -4.06 1.25 -3.78E-01
792 EIF3B 211501 s at 6.2879E-03 9.13E-05 -4.06 1.25 -6.90E-01
793 Sep-02 200778 s at 6.2879E-03 9.13E-05 -4.06 1.25 -4.44E-01
794 ZZZ3 229325 at 6.2879E-03 9.14E-05 4.06 1.25 2.70 E-01
795 241883 x at 6.2879E-03 9.14E-05 4.06 1.25 1.41 E-01
796 MVP 202180 s at 6.3078E-03 9.20 E-05 -4.05 1.24 -5.64E-01
797 FTL 213187 x at 6.3078E-03 9.21 E-05 -4.05 1.24 -5.84E-01
798 MGAT1 201126 s at 6.3078E-03 9.21 E-05 -4.05 1.24 -5.29E-01
799 GGT5 205582 s at 6.3188E-03 9.23E-05 -4.05 1.24 -7.16E-01
800 HSPA6 213418 at 6.3327E-03 9.27E-05 -4.05 1.23 -8.55E-01
801 CD151 204306 s at 6.3362E-03 9.28E-05 -4.05 1.23 -4.36E-01
802 TGOLN2 203834 s at 6.3384E-03 9.30E-05 -4.05 1.23 -3.74E-01
33
No. Gene* Probe ID** Adj. p value P value t B Log FC
803 ARMC8 219094 at 6.3529E-03 9.34E-05 4.05 1.23 2.67E-01
804 SLC16A3 202855 s at 6.3529E-03 9.34E-05 -4.05 1.23 -6.08E-01
805 ETHE1 204034 at 6.3546E-03 9.36E-05 -4.05 1.23 -4.43E-01
806 FKBP4 200895 s at 6.3654E-03 9.38E-05 -4.05 1.22 -3.94E-01
807 CLTC 200614 at 6.4079E-03 9.46E-05 -4.05 1.22 -3.04E-01
808 TRADD 205641 s at 6.4084E-Q3 9.47E-05 -4.05 1.21 -3.39E-01
809 C11 orf45 1553787 at 6.4097E-03 9.48E-05 -4.05 1.21 -1.59E-01
810 244028 at 6.4146E-03 9.52E-05 4.05 1.21 2.48E-01
811 ADA TS1 222486 s at 6.4146E-03 9.52 E-05 -4.05 1.21 -1.94E-01
812 HLA-DPA1 211990 at 6.4146E-03 9.53E-05 -4.04 1.21 -5.15E-01
813 ACRV1 206776 x at 6.4272E-03 9.56E-05 4.04 1.21 1.66E-01
814 BCKDK 202030 at 6.4282E-03 9.57E-05 -4.04 1.21 -5.04E-01
815 HSP90AA1 211969 at 6.4327E-03 9.62 E-05 -4.04 1.20 -5.41 E-01
816 PTGR1 231897 at 6.4327E-03 9.62E-05 -4.04 1.20 -6.40E-01
817 TRNP1 227862 at 6.4327E-03 9.63E-05 -4.04 1.20 -1.78E-01
818 242867 x at 6.4327E-03 9.63E-05 4.04 1.20 1.58E-01
819 DKK3 202196 s at 6.4327E-03 9.64E-05 -4.04 1.20 -3.43E-01
820 SERPINA1 211429_s at 6.4327E-03 9.65E-05 -4.04 1.20 -1.09E+00
821 RPN2 213399 x at 6.4431 E-03 9.67E-05 -4.04 1.20 -3.58E-01
822 MAPK4 204708 at 6.4562E-03 9.72E-05 4.04 1.19 1.62E-01
823 EPRS 200841 s at 6.4562E-03 9.72E-05 -4.04 1.19 -6.09E-01
824 GLG1 214730 s at 6.4724E-03 9.75E-05 -4.04 1.19 -6.72E-01
825 MBNL1 1558111 at 6.4818E-03 9.78E-05 4.04 1.19 7.32E-01
826 SURF4 222978 at 6.5070E-03 9.83E-05 -4.04 1.18 -5.93E-01
827 ACTR1A 200720 s at 6.5242E-03 9.87E-05 -4.04 1.18 -5.83E-01
828 CTTNBP2N 226000_at 6.5242E-03 9.88E-05 -4.04 1.18 -3.80E-01 L
829 HIST1 H3F/// 208576_s_at 6.5367E-03 9.92E-05 4.03 1.17 7.65E-01
HIST1 H3B///
HIST1 H3H///
HIST1 H3J///
HIST1 H3G///
HIST1 H3I///
HIST1 H3E///
HIST1 H3C///
HIST1 H3D///
HIST1 H3A///
HIST1 H2AD
830 WNT16 224022 x at 6.5367E-03 9.92E-05 4.03 1.17 1.68E-01
831 SLC2A5 204429 s at 6.5419E-03 9.96E-05 -4.03 1.17 -5.68E-01
832 PDIA6 208639 x at 6.5419E-03 9.96E-05 -4.03 1.17 -4.35E-01
833 RAB3GAP1 212932 at 6.5419E-03 9.97E-05 -4.03 1.17 -3.88E-01
834 SESN2 223195 s at 6.5419E-03 9.98E-05 -4.03 1.17 -3.27E-01
835 TIA1 201447 at 6.5624E-03 1.00E-04 4.03 1.16 4.36E-01
836 NRP2 225566 at 6.5624E-03 1.00E-04 -4.03 1.16 -4.19E-01
837 ZNF880 235913 at 6.5650E-03 1.01 E-04 4.03 1.16 5.63E-01
838 ZNF141 206931 at 6.5650E-03 1.01 E-04 4.03 1.16 3.59E-01
839 PCSK5 205560 at 6.5650E-03 1.01 E-04 -4.03 1.16 -5.69E-01
840 PTAFR 211661 x at 6.5869E-03 1.01 E-04 -4.03 1.15 -9.22E-01
841 OCEL1 205441 at 6.5869E-03 1.01 E-04 -4.03 1.15 -2.15E-01
842 MPP1 202974 at 6.5869E-03 1.01 E-04 -4.03 1.15 -6.78E-01
843 ZNF138 244743 x at 6.5966E-03 1.02E-04 4.03 1.15 4.24E-01
844 CHN2 213385 at 6.5966E-03 1.02E-04 -4.03 1.15 -6.58E-01
845 TO 40L 226059 at 6.5966E-03 1.02E-04 -4.03 1.15 -2.68E-01
846 C17orf108 213195 at 6.6 89E-03 1.02E-04 4.03 1.14 3.72E-01
847 PALLD 200907 s at 6.6287E-03 1.03E-04 -4.02 1.14 -5.09E-01
848 TRIM8 223132 s at 6.6468E-03 1.03E-04 -4.02 1.14 -6.29E-01
849 RNF146 221430 s at 6.6806E-03 1.04E-04 -4.02 1.13 -4.24E-01
850 230444 at 6.6889E-03 1.04E-04 4.02 1.13 6.01 E-01
851 BOLA2 231500 s at 6.6889E-03 1.04E-04 4.02 1.13 4.78E-01
852 TM9SF2 201078 at 6.7037E-03 1.05E-04 -4.02 1.13 -4.89E-01
853 NCRNA002 226835_s_at 6.7037E-03 1.05E-04 4.02 1.12 6.99E-01 75
854 RRBP1 201206 s at 6.7037E-03 1.05E-04 -4.02 1.12 -5.51 E-01
855 MCAM 211340 s at 6.7488E-03 1.06E-04 -4.02 1.12 -5.54E-01
856 231431 s at 6.7559E-03 1.06E-04 -4.02 1.11 -3.94E-01
857 GALNT10 207357 s at 6.7559E-03 1.06E-04 -4.02 1.11 -4.39E-01
858 ANXA2 201590 x at 6.7692E-03 1.06E-04 -4.02 1.11 -4.51 E-01
859 1561226 at 6.7743E-03 1.06E-04 -4.02 1.11 -3.71 E-01
860 L3MBTL2 1555815 a at 6.8023E-03 1.07E-04 -4.01 1.10 -4.35E-01
No. Gene* Probe ID** Adj. p value P value ί B Log FC
861 KD 1 B 227021 at 6.8108E-03 1.07E-04 -4.01 1.10 -5.50E-01
862 GSPT1 240452 at 6.8108E-03 1.07E-04 4.01 1.10 4.43E-01
863 CALU 214845 s at 6.8308E-03 1.08E-04 -4.01 1.10 -7.71 E-01
864 226311 at 6.8465E-03 1.08E-04 -4.01 1.09 -9.45E-01
865 FBLI 1 225258 at 6.8661 E-03 1.09E-04 -4.01 1.09 -5.85E-01
866 DLEU1 205677 s at 6.8670E-03 1.09E-04 4.01 1.09 6.86E-01
867 CRK 202226 s at 6.8670E-03 1.09E-04 -4.01 1.09 -5.50E-01
868 CALU 200755 s at 6.8670E-03 1.09E-04 -4.01 1.09 -6.45E-01
869 234590 x at 6.8670E-03 1.09E-04 4.01 1.09 1.79E-01
870 VTH B 225928 at 6.8691 E-03 1.10E-04 -4.01 1.08 -4.43E-01
871 SYS1- 218094_s_at 6.8691 E-03 1.10E-04 -4.01 1.08 -4.80E-01
DBNDD2///D
BNDD2
872 ATF7IP 207728 at 6.8691 E-03 1.10E-04 4.01 1.08 1.48E-01
873 IL13RA1 201888 s at 6.8691 E-03 1.10E-04 -4.01 1.08 -5.76E-01
874 T E 43 222418 s at 6.8691 E-03 1.10E-04 -4.01 1.08 -5.12E-01
875 233021 at 6.8691 E-03 1.10E-04 4.01 1.08 2.73E-01
876 SELENBP1 214433 s at 6.8827E-03 1.10E-04 -4.01 1.08 -4.36E-01
877 GIT2 204982 at 6.8886E-03 1.10E-04 4.01 1.08 4.41E-01
878 E ILIN2 224374 s at 6.8892E-03 1.11 E-04 -4.00 1.07 -6.95E-01
879 CALD1 212077 at 6.9027E-03 1.11 E-04 -4.00 1.07 -6.10E-01
880 ZNF678 1554922 at 6.9217E-03 1.11 E-04 4.00 1.07 1.65E-01
881 ZNF254 242602 x at 6.9271 E-03 1.12E-04 4.00 1.07 3.56E-01
882 VIM 201426 s at 6.9434E-03 1.12E-04 -4.00 1.06 -6.19E-01
883 TNIP1 207196 s at 6.9434E-03 1.12E-04 -4.00 1.06 -5.18E-01
884 UBE2F 225787 at 6.9434E-03 1.12E-04 -4.00 1.06 -4.89E-01
885 C21orf33 202217 at 6.9441 E-03 1.12E-04 -4.00 1.06 -2.27E-01
886 ABCC6P1 236205 at 6.9565E-03 1.13E-04 4.00 1.06 1.56E-01
887 EIF3E 208697 s at 6.9565E-03 1.13E-04 4.00 1.06 3.81 E-01
888 NCRNA002 223740_at 6.9808E-03 1.13E-04 4.00 1.05 2.14E-01 41
889 ADCY3 209321 s at 6.9808E-03 1.14E-04 -4.00 1.05 -5.11 E-01
890 ZNF273 215239 x at 6.9895E-03 1.14E-04 4.00 1.05 3.56E-01
891 HSP90AB1 214359 s at 7.0020E-03 1.14E-04 -4.00 1.05 -1.07E+00
892 SLC38A7 56821 at 7.0034E-03 1.14E-04 -4.00 1.04 -4.01 E-01
893 PSMD7 201705 at 7.0034E-03 1.14E-04 -4.00 1.04 -3.58E-01
894 RPS27L 218007 s at 7.0058E-03 1.15E-04 4.00 1.04 4.43E-01
895 231237 x at 7.0360E-03 1.15E-04 3.99 1.04 3.09E-01
896 STAP1 220059 at 7.0360E-03 1.15E-04 3.99 1.04 1.17E+00
897 TUBA1 B 211058 x at 7.0360E-03 1.16E-04 -3.99 1.04 -3.54E-01
898 ADAMTS1 222162 s at 7.0360E-03 1.16E-04 -3.99 1.03 -7.54E-01
899 BCOR 223915 at 7.0361 E-03 1.16E-04 3.99 1.03 5.33E-01
900 TSPAN4 209264 s at 7.0361 E-03 1.16E-04 -3.99 1.03 -8.38E-01
901 C8orf68 1554978 at 7.0361 E-03 1.16E-04 3.99 1.03 2.25E-01
902 FGF22 1566814 at 7.0408E-03 1.16E-04 3.99 1.03 2.02E-01
903 PPYR1 210956 at 7.0413E-03 1.16E-04 3.99 1.03 1.93E-01
904 STOM 201060 x at 7.0413E-03 1.16E-04 -3.99 1.03 -4.77E-01
905 NDUFA11 228690 s at 7.0413E-03 1.17E-04 3.99 1.03 4.94E-01
906 ANAPC16 224664 at 7.0546E-03 1.17E-04 3.99 1.02 4.91 E-01
907 SEL1 L 202062 s at 7.0987E-03 1.18E-04 -3.99 1.02 -4.90E-01
908 1562546 at 7.1090E-03 1.18E-04 3.99 1.02 2.46E-01
909 GPC1 202756 s at 7.1090E-03 1.18E-04 -3.99 1.01 -2.74E-01
910 VMA21 235237 at 7.1185E-03 1.19E-04 3.99 1.01 3.35E-01
911 RPS21 214097 at 7.1185E-03 1.19E-04 3.99 1.01 1.00E+00
912 SDF4 224472 x at 7.1314E-03 1.19E-04 -3.99 1.01 -5.15E-01
913 DLG1 202516 s at 7.1314E-03 1.19E-04 -3.98 1.01 -1.79E-01
914 TROAP 1568596 a at 7.1373E-03 1.19E-04 3.98 1.01 4.53E-01
915 TIMP2 224560 at 7.1373E-03 1.19E-04 -3.98 1.01 -9.63E-01
916 FAM167B 223657 at 7.1405E-03 1.20E-04 -3.98 1.00 -3.17E-01
917 DLC1 210762 s at 7.1625E-03 1.20E-04 -3.98 1.00 -6.89E-01
918 237859 at 7.1638E-03 1.20E-04 3.98 1.00 1.31 E-01
919 IFI30 201422 at 7.1638E-03 1.20E-04 -3.98 1.00 -7.49E-01
920 239479 x at 7.1875 E-03 1.21 E-04 3.98 0.99 2.96E-01
921 GPR107 211979 at 7.1982E-03 1.21 E-04 -3.98 0.99 -3.11 E-01
922 PYROXD1 219802 at 7.2240E-03 1.22E-04 3.98 0.99 4.68E-01
923 SERINC3 221473 x at 7.2240E-03 1.22E-04 -3.98 0.99 -4.77E-01
924 SLC22A18A 206097_at 7.2351 E-03 1.22E-04 3.98 0.98 2.35E-01 S
925 PASK 216945 x at 7.2650E-03 1.23E-04 3.98 0.98 7.12E-01
No. Gene* Probe ID** Adj. p value P value f S Log FC
926 KIAA0922 235674 at 7.3016E-03 1.24E-04 3.97 0.97 4.56E-01
927 231174 s at 7.3026E-03 1.24E-04 -3.97 0.97 -2.32E-01
928 COL4A1 21 1981 at 7.3161 E-03 1.24E-04 -3.97 0.97 -9.04E-01
929 RPL18P11 222297 x at 7.3355E-03 1.25E-04 3.97 0.97 2.16E-01
930 UBR2 215558 at 7.3463E-03 1.25E-04 3.97 0.96 1.82E-01
931 SVIP 230005_at 7.3463E-03 1.25E-04 3.97 0.96 3.56E-01
932 NDUFB1 206790 s at 7.3463E-03 1.25E-04 3.97 0.96 3.75E-01
933 SNX2 202113 s at 7.3463E-03 1.26E-04 -3.97 0.96 -7.38E-01
934 IQGAP1 213446 s at 7.3463E-03 1.26E-04 -3.97 0.96 -7.17E-01
935 231169 at 7.3463E-03 1.26E-04 -3.97 0.96 -4.54E-01
936 ZNF277 215887_at 7.3463E-03 1.26E-04 3.97 0.96 3.54E-01
937 LRPAP1 201186 at 7.3463E-03 1.26E-04 -3.97 0.96 -3.90E-01
938 SDC1 201287 s at 7.3463E-03 1.26E-04 -3.97 0.95 -8.09E-01
939 CFL1 200021 at 7.3463E-03 1.27E-04 -3.97 0.95 -6.08E-01
940 TOX4 232097 at 7.3463E-03 1.27E-04 3.97 0.95 3.49E-01
941 ETTL12/// 238680_at 7.3463E-03 1.27E-04 3.97 0.95 2.26E-01 SNORA57
942 TNFRSF25 216042 at 7.3463E-03 1.27E-04 3.97 0.95 2.38E-01
943 ZNF541 232604 at 7.3463E-03 1.27E-04 3.97 0.95 3.02E-01
944 C2///CFB 202357 s at 7.3463E-03 1.27E-04 -3.97 0.95 -8.27E-01
945 NOP56 200874 s at 7.3637E-03 1.27E-04 -3.97 0.95 -3.01 E-01
946 F2R 203989 x at 7.3785E-03 1.28E-04 -3.97 0.95 -4.61 E-01
947 PN A1 218224 at 7.3880E-03 1.28E-04 -3.97 0.94 -3.35E-01
948 ZNF493///Z 240155_x_at 7.3880E-03 1.28E-04 3.96 0.94 4.48E-01 NF738///ZN
F273
949 242839 at 7.3880E-03 1.28E-04 3.96 0.94 2.1 1E-01
950 LILRA2 21 1 100 x at 7.3880E-03 1.28E-04 -3.96 0.94 -3.81 E-01
951 KLF3 225133 at 7.4084E-03 1.29E-04 -3.96 0.94 -5.24E-01
952 DISP1 235466 s at 7.4112E-03 1.29E-04 3.96 0.94 8.60E-01
953 COMT 208818 s at 7.4402E-03 1.30E-04 -3.96 0.93 -5.03E-01
954 LPHN1 203488 at 7.4737E-03 1.31 E-04 -3.96 0.93 -2.14E-01
955 227184 at 7.4737E-03 1.31 E-04 -3.96 0.92 -5.78E-01
956 TUBA1 B 213646 x at 7.4737E-03 1.31 E-04 -3.96 0.92 -4.31 E-01
957 TRIP4 203732 at 7.4737E-03 1.31 E-04 -3.96 0.92 -4.18E-01
958 LOC400960 227969 at 7.4737E-03 1.31 E-04 -3.96 0.92 -3.81 E-01
959 ZNF93 208119 s at 7.4737E-03 1.32E-04 3.96 0.92 2.86E-01
960 CDKN1A 202284 s at 7.4737E-03 1.32E-04 -3.96 0.92 -5.43E-01
961 DNAJB6 209015 s at 7.4737E-03 1.32E-04 -3.96 0.92 -5.25E-01
962 RPL32 200674 s at 7.4737E-03 1.32E-04 3.96 0.92 1.75E-01
963 LRPPRC 1557360 at 7.4737E-03 1.32E-04 3.96 0.92 4.28E-01
964 SERPINF1 202283 at 7.4737E-03 1.32E-04 -3.96 0.92 -8.12 E-01
965 SCARB2 224983 at 7.4737E-03 1.32E-04 -3.96 0.91 -7.17E-01
966 LOC643763 1558388 a at 7.4737E-03 1.32E-04 3.96 0.91 1.02E-01
967 RPPH1 1556684 at 7.4737E-03 1.32E-04 3.96 0.91 2.62E-01
968 BACE1 217904 s at 7.4737E-03 1.33E-04 -3.96 0.91 -3.68E-01
969 EFR3B 215328 at 7.4737E-03 1.33E-04 3.96 0.91 2.31 E-01
970 C10orf31 1560255 at 7.4737E-03 1.33E-04 3.96 0.91 2.00E-01
971 ACBD5 1568877 a at 7.4737E-03 1.33E-04 -3.95 0.91 -2.97E-01
972 SERINC3 211769 x at 7.4737E-03 1.33E-04 -3.95 0.91 -6.07E-01
973 RNH1 206050 s at 7.4737E-03 1 33E-04 -3.95 0.91 -6.10E-01
974 LOC439949 232001 at 7.4737E-03 1.33E-04 3.95 0.91 7.02E-01
975 HIST1 H4J 214463 x at 7.5249E-03 1.34E-04 3.95 0.90 7.40E-01
976 VPS24 217837 s at 7.5380E-03 1.35E-04 -3.95 0.90 -6.27E-01
977 FA 20C 226722 at 7.5380E-03 1.35E-04 -3.95 0.90 -7.65E-01
978 229968 at 7.5380E-03 1.35E-04 -3.95 0.90 -4.76E-01
979 CCNG2 202769 at 7.5482E-03 1.35E-04 3.95 0.89 3.60E-01
980 SFXN3 217226 s at 7.5482E-03 1.35E-04 -3.95 0.89 -4.58E-01
981 DENND3 212974 at 7.5482E-03 1.36E-04 -3.95 0.89 -3.13E-01
982 T BI 6 200803 s at 7.5482E-03 1.36E-04 -3.95 0.89 -5.09E-01
983 T E 115 216267 s at 7.5482E-03 1.36E-04 -3.95 0.89 -3.77E-01
984 APKAP1 229846 s at 7.5541 E-03 1.36E-04 -3.95 0.89 -4.47E-01
985 237301 at 7.5680E-03 1.36E-04 3.95 0.89 2.19E-01
986 236609 at 7.5680E-03 1.36E-04 3.95 0.89 2.21 E-01
987 AN2B1 209166 s at 7.5813E-03 1.37E-04 -3.95 0.88 -5.96E-01
988 ID2 208384 s at 7.5813E-03 1.37E-04 -3.95 0.88 -1.91 E-01
989 NFE2L1 214179 s at 7.5813E-03 1.37E-04 -3.95 0.88 -3.59E-01
990 BLVRA 203773 x at 7.5813E-03 1.38E-04 -3.95 0.88 -3.90E-01
991 C1orf85 225401 at 7.5813E-03 1.38E-04 -3.95 0.88 -5.96E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
992 SLC27A4 225779 at 7.5813E-03 1.38E-04 -3.95 0.88 -3.01 E-01
993 GLUL 200648 s at 7.5813E-03 1.38E-04 -3.95 0.88 -1.11 E+00
994 ZNF626 1552643 at 7.5813E-03 1.38E-04 3.94 0.88 5.47E-01
995 FNTB 225851 at 7.5813E-03 1.38E-04 -3.94 0.88 -3.63E-01
996 FAM120A 200767 s at 7.6167E-03 1.39E-04 -3.94 0.87 -3.87E-01
997 SPACA1 220982 s at 7.6188E-03 1.39E-04 3.94 0.87 1.57E-01
998 LAIR1 210644 s at 7.6188E-03 1.39E-04 -3.94 0.87 -6.70E-01
999 TUBA1B 21 1072 x at 7.6188E-03 1.39E-04 -3.94 0.87 -3.44E-01
1000 1569834 at 7.6188E-03 1.39E-04 3.94 0.87 2.67E-01
1001 1565913__at 7.6343E-03 1.40E-04 3.94 0.86 2.40E-01
1002 GJD3 230025 at 7.6351 E-03 1.40E-04 -3.94 0.86 -4.88E-01
1003 SOD2 216841 s at 7.6493E-03 1.40E-04 -3.94 0.86 -6.43E-01
1004 GCOM1///G 212243_at 7.6580E-03 1.41 E-04 3.94 0.86 3.27E-01 RINL1A
1005 235697 at 7.6842E-03 1.41 E-04 3.94 0.85 3.36E-01
1006 PFKL 201 102 s at 7.6951 E-03 1.42E-04 -3.94 0.85 -3.36E-01
1007 ARCN1 201176 s at 7.6961 E-03 1.42E-04 -3.94 0.85 -4.64E-01
1008 CD36 206488 s at 7.6966E-03 1.42E-04 -3.94 0.85 -8.62E-01
1009 RPN2 213491 x at 7.7145E-03 1.42E-04 -3.94 0.85 -3.57E-01
1010 FGFR1 222164 at 7.7145E-03 1.43E-04 3.94 0.85 5.45E-01
1011 ANXA2 210427 x at 7.7596E-03 1.43E-04 -3.93 0.84 -4.38E-01
1012 AP2M1 200613 at 7.7769E-03 1.44E-04 -3.93 0.84 -6.70E-01
1013 CAPNS1 200001 at 7.7934E-03 1.44E-04 -3.93 0.83 -8.92E-01
1014 PCSK2 204870 s at 7.7977E-03 1.45E-04 3.93 0.83 1.96E-01
1015 HIST1H2BD 222067 x at 7.8007E-03 1.45E-04 3.93 0.83 6.01 E-01
1016 MYOF 21 1864 s at 7.8129E-03 1.45E-04 -3.93 0.83 -8.96E-01
1017 HIST1 H1B 214534 at 7.8887E-03 1.47E-04 3.93 0.82 5.37E-01
1018 SNCG 209877 at 7.8970E-03 1.47E-04 3.93 0.82 2.66E-01
1019 237883 at 7.9145E-03 1.48E-04 3.93 0.81 2.30E-01
1020 GPT 206709 x at 7.9145E-03 1.48E-04 3.93 0.81 2.21 E-01
1021 CEP63 222151_s_at 7.9145E-03 1.48E-04 -3.93 0.81 -4.01 E-01
1022 RUSC1 206949_s_at 7.9145E-03 1.48E-04 -3.93 0.81 -4.08E-01
1023 GTF3A 215091 s at 7.9145E-03 1.48E-04 3.93 0.81 3.66E-01
1024 CNDP2 217752 s at 7.9289E-03 1.49E-04 -3.92 0.81 -5.1 1E-01
1025 GPX3 201348 at 7.9289E-03 1.49E-04 -3.92 0.81 -1.22E+00
1026 LOC285972 1560762 at 7.9289E-03 1.49E-04 3.92 0.81 4.82E-01
1027 GOLM1 217771 at 7.9416E-03 1.49E-04 -3.92 0.80 -8.87E-01
1028 MYL9 201058 s at 7.9420E-03 1.49E-04 -3.92 0.80 -1.06E+00
1029 ZNF292 212368 at 7.9420E-03 1.49E-04 3.92 0.80 2.93E-01
1030 VPS53 227229 at 7.9526E-03 1.50E-04 -3.92 0.80 -3.39E-01
1031 RCAN1 208370 s at 7.9868E-03 1.51 E-04 -3.92 0.80 -5.64E-01
1032 CCDC93 209689 at 7.9868E-03 1.51 E-04 -3.92 0.80 -3.28E-01
1033 CD93 202877 s at 7.9868E-03 1.51 E-04 -3.92 0.79 -6.21E-01
1034 FAM13A 217047 s at 7.9868E-03 1.51 E-04 -3.92 0.79 -5.27E-01
1035 LOC100131 244659_at 7.9868E-03 1.51 E-04 3.92 0.79 3.86E-01 015
1036 RPS16 226131 s at 8.0769E-03 1.53E-04 3.92 0.78 1.19E-01
1037 KCND3 215014 at 8.1023E-03 1.54E-04 -3.92 0.78 -1.88E-01
1038 ZNF695 208273 at 8.1023E-03 1.54E-04 3.92 0.78 2.01 E-01
1039 TC2N 234970 at 8.1212E-03 1.54E-04 3.91 0.77 4.82E-01
1040 RICTOR 228248 at 8.1212E-03 1.54E-04 3.91 0.77 3.45E-01
1041 MSX2 210319 x at 8.1212E-03 1.55E-04 -3.91 0.77 -3.54E-01
1042 FTL 212788 x at 8.1250E-03 1.55E-04 -3.91 0.77 -3.26E-01
1043 LOC653566/ 201239_s_at 8.1427E-03 1.55E-04 -3.91 0.77 -4.42E-01 //SPCS2
1044 PHF7 221930 at 8.1466E-03 1.56E-04 3.91 0.77 1.41 E-01
1045 SDF4 221972 s at 8.1588E-03 1.56E-04 -3.91 0.77 -7.86E-01
1046 FLU 222065 s at 8.1826E-03 1.57E-04 -3.91 0.76 -6.95E-01
1047 1558876 at 8.1826E-03 1.57E-04 3.91 0.76 1.92E-01
1048 XBP1 200670 at 8.1826E-03 1.57E-04 -3.91 0.76 -6.42E-01
1049 ARPC2 208679 s at 8.1826E-03 1.57E-04 -3.91 0.76 -4.10E-01
1050 RAB1A 207791 s at 8.1826E-03 1.58E-04 -3.91 0.76 -7.13E-01
1051 237698 at 8.1826E-03 1.58E-04 3.91 0.76 1.73E-01
1052 NES 218678 at 8.1826E-03 1.58E-04 -3.91 0.76 -4.21 E-01
1053 CROCCL1 1569293 x at 8.1826E-03 1.58E-04 3.91 0.75 3.17E-01
1054 MS4A6A 223922 x at 8.1826E-03 1.58E-04 -3.91 0.75 -6.47E-01
1055 1557276 at 8.1826E-03 1.58E-04 3.91 0.75 2.27E-01
1056 K1F6 1556233 s at 8.1826E-03 1.58E-04 3.91 0.75 1.65E-01
1057 CLN5 204084 s at 8.2018E-03 1.59E-04 -3.91 0.75 -3.89E-01
No. Gene* Probe ID** Adj. p value P value t S Log FC
1058 DNASE1 L1 203912 s at 8.2018E-03 1.59E-04 -3.91 0.75 -3.71 E-01
1059 CDC14B 211347 at 8.2103E-03 1.59E-04 3.91 0.75 1.77E-01
1060 ARAP2 214102 at 8.2103E-03 1.59E-04 3.91 0.75 3.30E-01
1061 RAP1A 1555340_x at 8.2103E-03 1.59E-04 3.91 0.75 1.79E-01
1062 YIF1B 1554553 s at 8.2213 E-03 1.60E-04 -3.90 0.74 -6.14E-01
1063 LOC 126536 1555988 a at 8.2219E-03 1.60E-04 3.90 0.74 1.43E-01
1064 MOSC1 218865 at 8.2219E-03 1.60E-04 -3.90 0.74 -2.92E-01
1065 ZNF527 1570238 at 8.2219E-03 1.60E-04 3.90 0.74 2.01 E-01
1066 HLA-C 216526 x at 8.2219E-03 1.60E-04 -3.90 0.74 -3.13E-01
1067 RNASEH2B 219056 at 8.2565E-03 1.61 E-04 3.90 0.74 4.81 E-01
1068 SLC25A13 203775 at 8.2568E-03 1.61 E-04 -3.90 0.73 -3.03E-01
1069 PNKD 233177 s at 8.2637E-03 1.62E-04 -3.90 0.73 -7.28E-01
1070 PLEK 203471 s at 8.2637E-03 1.62E-04 -3.90 0.73 -5.46E-01
1071 1569802_at 8.3248E-03 1.63E-04 3.90 0.72 1.46E-01
1072 227979 at 8.3306E-03 1.63E-04 3.90 0.72 4.69E-01
1073 LRRC7 242050_at 8.3531 E-03 1.64E-04 3.90 0.72 1.67E-01
1074 STIP1 212009 s at 8.3545E-03 1.64E-04 -3.90 0.72 -7.81 E-01
1075 COX7C 213846 at 8.3935E-03 1.65E-04 3.90 0.71 5.72E-01
1076 ZFX 229022 at 8.4062E-03 1.66E-04 3.89 0.71 4.07E-01
1077 PON2 210830 s at 8.4062E-03 1.66E-04 -3.89 0.71 -6.45E-01
1078 HLA-C 211799 x at 8.4062E-03 1.66E-04 -3.89 0.71 -5.69E-01
1079 LOC285771 237870 at 8.4062E-03 1.66E-04 3.89 0.71 1.84E-01
1080 KPNA5 227934 at 8.4062E-03 1.66E-04 3.89 0.71 4.64E-01
1081 KD 4B 212495 at 8.4062E-03 1.66E-04 -3.89 0.71 -4.17E-01
1082 PYROXD1 231173 at 8.4062E-03 1.66E-04 3.89 0.71 1.96E-01
1083 PGK1 200738 s at 8.4062E-03 1.67E-04 -3.89 0.71 -3.80E-01
1084 DCLRE1C 235478_at 8.4062E-03 1.67E-04 3.89 0.71 3.64E-01
1085 FRMD4A 225163 at 8.4133E-03 1.67E-04 -3.89 0.70 -5.95E-01
1086 MET 203510 at 8.4133 E-03 1.67E-04 -3.89 0.70 -5.24E-01
1087 RPS15P3/// 234900_at 8.4364E-03 1.68E-04 3.89 0.70 2.12E-01 RPLP1 P3///
METTL13///
DNM3
1088 FAM129A 217966 s at 8.4637E-03 1.69E-04 -3.89 0.70 -5.83E-01
1089 FRAT2 209864 at 8.4637E-03 1.69E-04 -3.89 0.69 -4.19E-01
1090 CD59 200983 x at 8.4881 E-03 1.69E-04 -3.89 0.69 -5.18E-01
1091 CYB561 209164 s at 8.5117E-03 1.70E-04 -3.89 0.69 -4.32E-01
1092 SCARNA15 228930 at 8.5117E-03 1.70E-04 3.89 0.69 4.42E-01
1093 FGFR2 208234 x at 8.5299E-03 1.71 E-04 3.89 0.68 2.81 E-01
1094 TADA3 215272 at 8.5299E-03 1.71 E-04 3.89 0.68 1.97E-01
1095 1556511 a at 8.5395E-03 1.71 E-04 3.89 0.68 1.63E-01
1096 TTC7B 226152 at 8.5395E-03 1.71 E-04 -3.89 0.68 -6.29E-01
1097 YWHAH 201020 at 8.5450E-03 1.71 E-04 -3.89 0.68 -6.38E-01
1098 226834 at 8.5450E-03 1.72E-04 -3.89 0.68 -6.44E-01
1099 NR2C1 210530 s at 8.5518E-03 1.72E-04 3.88 0.68 2.74E-01
1100 236825 at 8.5569E-03 1.72E-04 3.88 0.68 3.20E-01
1101 SLC16A3 202856 s at 8.5606E-03 1.73E-04 -3.88 0.67 -8.39E-01
1102 RASSF4 49306 at 8.5606E-03 1.73E-04 -3.88 0.67 -6.40E-01
1103 WSB2 201760 s at 8.5606E-03 1.73E-04 -3.88 0.67 -3.34E-01
1104 KLC1 212878 s at 8.5608E-03 1.73E-04 -3.88 0.67 -6.42E-01
1 105 CTSL1 202087 s at 8.5625E-03 1.73E-04 -3.88 0.67 -6.36E-01
1106 OS9 200714 x at 8.5949E-03 1.74E-04 -3.88 0.67 -4.55E-01
1107 CYSLTR1 230866 at 8.5949E-03 1.74E-04 3.88 0.67 4.97E-01
1108 PILRA 222218 s at 8.5949E-03 1.74E-04 -3.88 0.67 -1.03E+00
1109 CCL11 210133 at 8.6002E-03 1.74E-04 -3.88 0.66 -1.58E+00
1110 242609 x at 8.6066E-03 1.75E-04 3.88 0.66 2.60E-01
1111 HSP90AB1 1557910 at 8.6084E-03 1.75 E-04 -3.88 0.66 -1.04E+00
1112 PCOLCE 202465 at 8.6096E-03 1.75E-04 -3.88 0.66 -8.33E-01
1113 240032 at 8.6677E-03 1.77E-04 3.88 0.65 2.16E-01
11 14 FIP1 L1 1554424 at 8.6677E-03 1.77E-04 -3.88 0.65 -1.74E-01
1 1 15 CTSB 213274 s at 8.7316E-03 1.78E-04 -3.87 0.65 -1.14E+00
11 16 1558740 s at 8.7316E-03 1.78E-04 3.87 0.64 4.57E-01
1 117 GAB2 203853 s at 8.7371 E-03 1.79E-04 -3.87 0.64 -4.18E-01
11 18 DNAJB1 200666 s at 8.7371 E-03 1.79E-04 -3.87 0.64 -5.06E-01
1 119 VSIG4 204787 at 8.7371 E-03 1.79E-04 -3.87 0.64 -1.41 E+00
1 120 237034 at 8.7538E-03 1.79E-04 3.87 0.64 2.67E-01
1 121 HLA-C 208812 x at 8.7538E-03 1.79E-04 -3.87 0.64 -3.81 E-01
1 122 LOC100132 227234_at 8.7597E-03 1.80E-04 3.87 0.64 2.79E-01 815
No. Gene* Probe ID** Adj. p value P value f B Log FC
1123 FOLR2 204829 s at 8.8384E-03 1.82E-04 -3.87 0.63 -6.15E-01
1124 AKR1A1 201900 s at 8.8384E-03 1.82E-04 -3.87 0.63 -3.61 E-01
1125 SGSH 204293 at 8.8384E-03 1.82E-04 -3.87 0.63 -3.13E-01
1126 PELI1 232304 at 8.8384E-03 1.82E-04 3.87 0.62 5.45E-01
1127 FLJ 10357 58780 s at 8.8384E-03 1.82E-04 -3.87 0.62 -4.99E-01
1128 PPHLN1 1555351 s at 8.8384E-03 1.82E-04 3.87 0.62 2.26E-01
1129 BACH1 234938 at 8.8426E-03 1.83E-04 3.87 0.62 1.93E-01
1130 MANF 202655 at 8.8639E-03 1.83E-04 -3.87 0.62 -3.66E-01
1131 CCDC58 235244 at 8.8639E-03 1.83E-04 3.87 0.62 6.99E-01
1132 CISH 221223 x at 8.9032E-03 1.84E-04 -3.87 0.61 -5.55E-01
1133 MERTK 206028 s at 8.9109E-03 1.85E-04 -3.86 0.61 -5.67E-01
1134 HSPA1B///H 200800_s_at 8.9130E-03 1.85E-04 -3.86 0.61 -8.44E-01 SPA1A
1135 ZNF92 235170 at 8.9255E-03 1.85E-04 3.86 0.61 4.39E-01
1136 ICAM1 215485 s at 8.9255E-03 1.85E-04 -3.86 0.61 -4.60E-01
1137 STEAP4 225987 at 8.9376E-03 1.86E-04 -3.86 0.61 -1.04E+00
1138 AGPHD1 236150 at 8.9447E-03 1.86E-04 3.86 0.61 2.89E-01
1139 ALDH6A1 221588 x at 8.9564E-03 1.87E-04 -3.86 0.60 -4.95E-01
1140 NANS 218189 s at 8.9564E-03 1.87E-04 -3.86 0.60 -4.07E-01
1141 ASS1 207076 s at 8.9769E-03 1.87E-04 -3.86 0.60 -5.93E-01
1142 222284 at 8.9935E-03 1.88E-04 3.86 0.60 3.33E-01
1143 FHL1 210298 x at 8.9935E-03 1.88E-04 -3.86 0.60 -4.05E-01
1144 CYB5R3 201885 s at 8.9939E-03 1.88E-04 -3.86 0.60 -5.03E-01
1145 244600 at 9.0034E-03 1.89E-04 3.86 0.59 5.23E-01
1146 CATSPER2 1553323 a at 9.0034E-03 1.89E-04 3.86 0.59 1.65E-01
1147 FLOT1 210142 x at 9.0034E-03 1.89E-04 -3.86 0.59 -3.62E-01
1148 LILRB2 210146 x at 9.0034E-03 1.89E-04 -3.86 0.59 -1.14E+00
1149 PVRL2 232078 at 9.0100E-03 1.89E-04 -3.86 0.59 -3.71 E-01
1150 SNORA72 228047 at 9.0241 E-03 1.90E-04 3.86 0.59 3.22E-01
1151 FBX07 201178 at 9.0241 E-03 1.90E-04 -3.86 0.59 -4.52E-01
1152 LOC728613/ 1568763_s_at 9.0255E-03 1.90E-04 3.86 0.59 5.82E-01 //PDCD6
1153 VCAN 215646 s at 9.0255E-03 1.90E-04 -3.86 0.59 -1.38E+00
1154 CHD2 225951 s at 9.0255E-03 1.90E-04 3.86 0.58 4.16E-01
1155 SASH1 41644 at 9.0455E-03 1.91E-04 -3.86 0.58 -6.48E-01
1156 BACE1 222463 s at 9.0501 E-03 1.91 E-04 -3.86 0.58 -3.34E-01
1157 RHOQ 212120 at 9.0650E-03 1.92E-04 -3.85 0.58 -4.76E-01
1158 PMS2L11 210707 x at 9.0890E-03 1.93E-04 3.85 0.58 3.46E-01
1159 PCYOX1 203803 at 9.1132E-03 1.93E-04 -3.85 0.57 -6.07E-01
1160 DIAPH2 205726 at 9.1244E-03 1.94E-04 -3.85 0.57 -4.40E-01
1161 LMNA 1554600 s at 9.1944E-03 1.95E-04 -3.85 0.56 -5.67E-01
1162 TAF1 D 222728 s at 9.1944E-03 1.95E-04 3.85 0.56 3.11 E-01
1163 TACC1 1554690 a at 9.2180E-03 1.96E-04 -3.85 0.56 -5.46E-01
1164 C22orf9 212421 at 9.2343E-03 1.97E-04 -3.85 0.56 -3.21 E-01
1165 ATP5I 207335 x at 9.2343E-03 1.97E-04 3.85 0.56 5.75E-01
1166 ANXA1 201012 at 9.2386E-03 1.97E-04 -3.85 0.55 -7.29E-01
1167 COL6A1 212937 s at 9.2598E-03 1.98E-04 -3.85 0.55 -4.48E-01
1168 NDUFA7 1557532 at 9.2598E-03 1.98E-04 3.85 0.55 2.60E-01
1169 KLF11 218486 at 9.2637E-03 1.98E-04 -3.85 0.55 -4.72E-01
1170 1F1TM3 212203 x at 9.3440E-03 2.00E-04 -3.84 0.54 -6.11 E-01
1171 TRAF3IP3 231932 at 9.3852E-03 2.01 E-04 3.84 0.53 2.20E-01
1172 AHCYL1 200848 at 9.3852E-03 2.02E-04 -3.84 0.53 -4.69E-01
1173 SKAP2 225639 at 9.3852E-03 2.02E-04 -3.84 0.53 -3.58E-01
1174 FRYL 1563687 a at 9.3852E-03 2.02E-04 -3.84 0.53 -2.03E-01
1175 PRCP 201494 at 9.3852E-03 2.02E-04 -3.84 0.53 -3.45E-01
1176 SCN1 B 205508 at 9.3852E-03 2.02E-04 -3.84 0.53 -3.83E-01
1177 FNDC3B 225032 at 9.3852E-03 2.02E-04 -3.84 0.53 -5.88E-01
1178 SLC39A8 209267 s at 9.3852E-03 2.02E-04 -3.84 0.53 -8.15E-01
1179 ZNF101 1552633 at 9.3852E-03 2.03E-04 3.84 0.53 4.99E-01
1180 IL2RA 211269 s at 9.3852E-03 2.03E-04 -3.84 0.53 -6.72E-01
1181 LOC730631 230738 at 9.3853E-03 2.03E-04 3.84 0.53 3.79E-01
1182 235193 at 9.4205E-03 2.04E-04 3.84 0.52 3.60E-01
1183 COL6A1 212938 at 9.4205E-03 2.04E-04 -3.84 0.52 -2.09E-01
1184 ENG 201809 s at 9.4347E-03 2.04E-04 -3.84 0.52 -6.99E-01
1185 233115 at 9.4405E-03 2.05E-04 3.84 0.52 1.19E-01
1186 PPFIA1 210235 s at 9.4405E-03 2.05E-04 -3.84 0.52 -3.24E-01
1187 C17orf39 228452 at 9.4405E-03 2.05E-04 -3.84 0.52 -2.90E-01
1188 1TGA9 206009 at 9.4405E-03 2.05E-04 -3.84 0.52 -2.10E-01
1189 ANXA5 200782 at 9.4438E-03 2.05E-04 -3.84 0.52 -4.16E-01
No. Gene* Probe ID** Adj. p value P value t 0 Log FC
1190 CD2AP 236257 at 9.4757E-03 2.06E-04 3.83 0.51 1.95E-01
1191 RHOJ 1555233 at 9.4788E-03 2.07E-04 -3.83 0.51 -3.16E-01
1192 RRN3 222204 s at 9.4788E-03 2.07E-04 -3.83 0.51 -3.88E-01
1193 DHX30 230871 at 9.5534E-03 2.08E-04 3.83 0.50 6.53E-01
1194 TEL02 209528 s at 9.5769E-03 2.09E-04 3.83 0.50 2.68E-01
1195 SPIRE1 1554807 a at 9.5855E-03 2.10E-04 -3.83 0.50 -2.72E-01
1196 RFESD 236305 at 9.5855E-03 2.10E-04 3.83 0.50 2.45E-01
1197 HLA-DPA1 211991 s at 9.5855E-03 2.10E-04 -3.83 0.50 -7.00E-01
1198 SERPINA3 202376 at 9.5855E-03 2.10E-04 -3.83 0.50 -6.78E-01
1199 SKAP2 216899 s at 9.5886E-03 2.10E-04 -3.83 0.50 -6.73E-01
1200 FAM60A 220147 s at 9.6237E-03 2.11 E-04 3.83 0.49 3.59E-01
1201 BTN2A1 244063 at 9.6293E-03 2.12E-04 3.83 0.49 2.87E-01
1202 PI4K2A 215134_at 9.6293E-03 2.12E-04 -3.83 0.49 -3.03E-01
1203 BUB3 201458 s at 9.6293E-03 2.12E-04 3.83 0.49 2.58E-01
1204 AP3K1 225927 at 9.6293E-03 2.12E-04 3.83 0.49 5.06E-01
1205 GGCX 235413 at 9.6778E-03 2.13E-04 -3.82 0.48 -2.68E-01
1206 CA KK2 212252 at 9.6778E-03 2.14E-04 -3.82 0.48 -3.99E-01
1207 LOC285074 230588 s at 9.6778E-03 2.14E-04 3.82 0.48 4.38E-01
1208 1558348 at 9.6847E-03 2.14E-04 3.82 0.48 2.34E-01
1209 RC3H2 220202 s at 9.6847E-03 2.14E-04 -3.82 0.48 -5.41 E-01
1210 WISP1 206796 at 9.6930E-03 2.15E-04 -3.82 0.48 -5.48E-01
1211 CD36 228766 at 9.6930E-03 2.15E-04 -3.82 0.48 -8.86E-01
1212 FOSL2 218880 at 9.7076E-03 2.15E-04 -3.82 0.47 -5.79E-01
1213 TSPAN18 1561449 at 9.7076E-03 2.15E-04 3.82 0.47 2.09E-01
1214 NCR1 217095 x at 9.7076E-03 2.16E-04 3.82 0.47 2.38E-01
1215 240434 at 9.7208E-03 2.16E-04 3.82 0.47 3.46E-01
1216 244343 at 9.7336E-03 2.17E-04 3.82 0.47 1.69E-01
1217 PRPF31 202407_s_at 9.7336E-03 2.17E-04 -3.82 0.47 -5.04E-01
1218 237774 at 9.7425E-03 2.17E-04 3.82 0.47 2.08E-01
1219 LOC388889 232340 at 9.7784E-03 2.18E-04 3.82 0.46 4.40E-01
1220 FSTL1 208782 at 9.7784E-03 2.18E-04 -3.82 0.46 -8.63E-01
1221 CRLF3 205474 at 9.7784E-03 2.18E-04 3.82 0.46 3.14E-01
1222 IGFBP7 201162 at 9.7951 E-03 2.19E-04 -3.82 0.46 -4.80E-01
1223 HSP90AA1 211968 s at 9.8259E-03 2.20E-04 -3.82 0.46 -5.54E-01
1224 GTSF1 L 232821 at 9.8259E-03 2.20E-04 3.82 0.46 4.56E-01
1225 BRCA2 214727 at 9.8462E-03 2.21 E-04 3.82 0.45 1.37E-01
1226 222319 at 9.8825E-03 2.22E-04 3.81 0.45 1.91 E-01
1227 INA 1554774 at 9.8835E-03 2.22E-04 -3.81 0.45 -2.64E-01
1228 AP7D1 217943 s at 9.8835E-03 2.22E-04 -3.81 0.45 -6.03E-01
1229 RIN2 209684 at 9.8849E-03 2.22 E-04 -3.81 0.45 -6.93E-01
1230 TNFAIP3 202643 s at 9.8988 E-03 2.23E-04 -3.81 0.44 -5.44E-01
1231 ACVRL1 226950 at 9.9376E-03 2.24E-04 -3.81 0.44 -5.24E-01
1232 PCSK5 205559 s at 9.9376E-03 2.24E-04 -3.81 0.44 -7.82E-01
1233 ABCA11 P 220159 at 9.9376E-03 2.24E-04 3.81 0.44 3.29E-01
1234 ALDOA 238996 x at 9.9403E-03 2.24E-04 -3.81 0.44 -5.72E-01
1235 BTRC 1563620 at 9.9800E-03 2.25 E-04 3.81 0.43 1.20E-01
1236 RBP S 209488 s at 9.9842E-03 2.26E-04 -3.81 0.43 -7.80E-01
1237 STAG3 219753 at 9.9931 E-03 2.26E-04 3.81 0.43 6.53E-01
1238 NAAA 227135 at 1.0014E-02 2.27E-04 -3.81 0.43 -4.92E-01
1239 P S2L1 217485 x at 1.0017E-02 2.27E-04 3.81 0.43 3.63E-01
1240 TIA1 201449 at 1.0017E-02 2.27E-04 3.81 0.43 4.61 E-01
1241 APK7 207292 s at 1.0018E-02 2.27 E-04 -3.81 0.43 -2.36E-01
1242 EN01 217294 s at 1.0018E-02 2.28E-04 -3.81 0.43 -1.18E+00
1243 HIST2H4B/// 208580_x_at 1.0021 E-02 2.28 E-04 3.81 0.42 7.05E-01 HIST4H4///H
IST2H4A///H
IST1 H4U//H
IST1 H4E///H
IST1 H4B///H
IST1 H4H///H
IST1 H4C///H
IST1 H4J///HI
ST1H4K///HI
ST1 H4F///HI
ST1 H4D///HI
ST1 H4A //HI
ST1 H4I
1244 AGFG2 206821_x_at 1.0025E-02 2.28E-04 3.81 0.42 2.76E-01
1245 AARS 201000 at 1.0037E-02 2.29E-04 -3.81 0.42 -3.50E-01
1246 ITSN1 35776 at 1.0038E-02 2.29E-04 -3.81 0.42 -4.81 E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
1247 SNAPC5 213203 at 1.0038E-02 2.29E-04 3.81 0.42 3.63E-01
1248 FLJ44606 230404 at 1.0094E-02 2.31 E-04 3.80 0.41 2.74E-01
1249 SAMD10 233001 at 1.0094E-02 2.31 E-04 3.80 0.41 2.01 E-01
1250 FAM198B 223204 at 1.0094E-02 2.31 E-04 -3.80 0.41 -7.34E-01
1251 MS4A6A 223280 x at 1.0094E-02 2.31 E-04 -3.80 0.41 -6.56E-01
1252 ZNF540 229328 at 1.0094E-02 2.31 E-04 3.80 0.41 1.77E-01
1253 DNAJB4 203811 s at 1.0094E-02 2.31 E-04 -3.80 0.41 -2.41 E-01
1254 RBM47 222496 s at 1.0103E-02 2.32E-04 -3.80 0.41 -6.50E-01
1255 ANKS1A 212747 at 1.0111 E-02 2.32E-04 -3.80 0.41 -4.04E-01
1256 IDS 1559136 s at 1.0114E-02 2.32E-04 3.80 0.41 2.17E-01
1257 RPL27 200025 s at 1.0114E-02 2.33E-04 3.80 0.41 1.99E-01
1258 EPS8L1 221655 x at 1.0114E-02 2.33E-04 3.80 0.41 2.35E-01
1259 PMS2L1 239699 s at 1.0117E-02 2.33E-04 3.80 0.40 2.73E-01
1260 MAP4 243_g_at 1.0125E-02 2.33E-04 -3.80 0.40 -4.69E-01
1261 CHRDL1 209763 at 1.0127E-02 2.34E-04 -3.80 0.40 -9.92E-01
1262 KRT84 217031 at 1.0127E-02 2.34E-04 3.80 0.40 1.41 E-01
1263 SRP68 224607 s at 1.0143E-02 2.34E-04 -3.80 0.40 -4.08E-01
1264 236587 at 1.0188E-02 2.36E-04 3.80 0.39 1.68E-01
1265 WDR16 239916 at 1.0188E-02 2.36E-04 3.80 0.39 1.65E-01
1266 FERMT2 209209 s at 1.0188E-02 2.36E-04 -3.80 0.39 -5.69E-01
1267 MGC40069 243602 at 1.0203E-02 2.36E-04 3.80 0.39 6.44E-01
1268 RPS17 212578 x at 1.0203E-02 2.37E-04 3.80 0.39 2.59E-01
1269 C10orf78 236027 at 1.0214E-02 2.37E-04 3.80 0.39 5.03E-01
1270 LAMP2 226671 at 1.0215E-02 2.37E-04 -3.80 0.39 -5.10E-01
1271 PXK 1552275_s_at 1.0215E-02 2.38E-04 -3.79 0.39 -5.51 E-01
1272 CWF19L1 233568 x at 1.0215E-02 2.38E-04 3.79 0.39 2.34E-01
1273 ALKBH7 227879_at 1.0215E-02 2.38E-04 3.79 0.38 1.77E-01
1274 COL6A1 212091_s_at 1.0215E-02 2.38E-04 -3.79 0.38 -6.53E-01
1275 TMX2 201175 at 1.0215E-02 2.39E-04 -3.79 0.38 -3.45E-01
1276 FAM26F 229915 at 1 0215E-02 2.39E-04 -3.79 0.38 -3.90E-01
1277 RAP2B 227897 at 1.0215E-02 2.39E-04 -3.79 0.38 -6.28E-01
1278 PDLIM5 203242 s at 1.0215E-02 2.39E-04 -3.79 0.38 -3.97E-01
1279 SRGAP2 213329 at 1.0215E-02 2.39E-04 -3.79 0.38 -2.58E-01
1280 PARVB 37966 at 1.0226E-02 2.39E-04 -3.79 0.38 -4.76E-01
1281 DLX6 221289 at 1.0250E-02 2.40E-04 3.79 0.38 1.69E-01
1282 ACE 227463 at 1.0250E-02 2.40E-04 -3.79 0.38 -8.30E-01
1283 CD163 216233 at 1.0250E-02 2.41 E-04 -3.79 0.38 -6.11 E-01
1284 ARSD 223696 at 1.0250E-02 2.41 E-04 -3.79 0.37 -4.00E-01
1285 NR1 H2 218215 s at 1.0253E-02 2.41 E-04 -3.79 0.37 -5.00E-01
1286 FLOT1 208749 x at 1.0253E-02 2.41 E-04 -3.79 0.37 -3.77E-01
1287 COPA 208684 at 1.0253E-02 2.42E-04 -3.79 0.37 -5.67E-01
1288 THBD 203887 s at 1.0253E-02 2.42E-04 -3.79 0.37 -6.25E-01
1289 DPEP3 220179 at 1.0266E-02 2.42E-04 3.79 0.37 2.59E-01
1290 NDUFV3 226616 s at 1.0266E-02 2.42E-04 -3.79 0.37 -3.81 E-01
1291 PDCD7 230182 at 1.0266E-02 2.42E-04 3.79 0.37 1.90E-01
1292 233501 at 1.0294E-02 2.43E-04 3.79 0.36 2.37E-01
1293 SLC46A1 1552278 a at 1.0294E-02 2.43E-04 -3.79 0.36 -3.23E-01
1294 MCCC2 233231 at 1.0300E-02 2.44E-04 3.79 0.36 1.42E-01
1295 230598 at 1.0300E-02 2.44E-04 3.79 0.36 8.18E-01
1296 ZKSCAN1 214900 at 1.0326E-02 2.45E-04 3.79 0.36 1.67E-01
1297 FCGR2B 210889 s at 1.0340E-02 2.45E-04 -3.79 0.36 -9.53E-01
1298 SERPING1 200986 at 1.0343E-02 2.46E-04 -3.79 0.36 -1.01 E+00
1299 FCGRT 218831 s at 1.0343E-02 2.46E-04 -3.79 0.36 -6.62E-01
1300 RFX1 206321 at 1.0343E-02 2.46E-04 3.79 0.36 1.71 E-01
1301 YME1L1 216304 x at 1.0344E-02 2.46E-04 -3.79 0.35 -2.22E-01
1302 244529 at 1.0346E-02 2.46E-04 3.78 0.35 1.53E-01
1303 TRAT1 217147 s at 1.0346E-02 2.47E-04 3.78 0.35 7.74E-01
1304 RAB34 224710 at 1.0346E-02 2.47E-04 -3.78 0.35 -5.58E-01
1305 SLC43A3 213113 s at 1.0346E-02 2.47E-04 -3.78 0.35 -5.62E-01
1306 LOC389906 1564639 at 1.0346E-02 2.47E-04 3.78 0.35 2.03E-01
1307 EHD4 233660 at 1.0346E-02 2.48E-04 -3.78 0.35 -3.08E-01
1308 USP14 201671 x at 1.0346E-02 2.48E-04 -3.78 0.35 -3.52E-01
1309 TMSB15B/// 205347_s_at 1.0346E-02 2.48E-04 3.78 0.35 1.28E+00 T SB15A
1310 PCDHB18 234479 at 1.0346E-02 2.48E-04 3.78 0.35 1.83E-01
1311 SPRED1 235074 at 1.0347E-02 2.48E-04 -3.78 0.35 -3.66E-01
1312 SULF2 233555 s at 1.0361 E-02 2.49E-04 -3.78 0.34 -8.72E-01
1313 CUZD1 220275 at 1.0361 E-02 2.49E-04 3.78 0.34 3.68E-01
1314 TMEM51 218815 s at 1.0361 E-02 2.49E-04 -3.78 0.34 -4.16E-01
No. Gene* Probe ID** Adj. p value P value ί B Log FC
1315 CLEC1A 219761 at 1.0370E-02 2.49E-04 -3.78 0.34 -3.90E-01
1316 228812 at 1.0371 E-02 2.50E-04 3.78 0.34 5.47E-01
1317 HIST1 H2BC 208490_x_at 1.0406E-02 2.51 E-04 3.78 0.34 5.34E-01
///HIST1 H2B
I///HIST1 H2
BE///HIST1H
2BF///HIST1
H2BG
1318 NEUROD1 206282 at 1.0425E-02 2.51 E-04 3.78 0.34 1.61E-01
1319 1566702 at 1.0432E-02 2.52E-04 3.78 0.33 2.07E-01
1320 USMG5 225413 at 1.0432E-02 2.52E-04 3.78 0.33 4.05E-01
1321 AHCYL1 200850 s at 1.0437E-02 2.52E-04 -3.78 0.33 -4.54E-01
1322 SYK 209269 s at 1.0440E-02 2.52E-04 -3.78 0.33 -3.73E-01
1323 GPR84 223767 at 1.0440E-02 2.53E-04 -3.78 0.33 -8.18E-01
1324 ELL2 226099 at 1.0512E-02 2.55E-04 -3.78 0.32 -5.41 E-01
1325 TEX10 1558702 at 1.0512E-02 2.55E-04 3.78 0.32 2.10E-01
1326 LRCH3 1553668 at 1.0512E-02 2.55E-04 -3.78 0.32 -1.39E-01
1327 HIPK1 1552516_a_at 1.0512E-02 2.55E-04 -3.77 0.32 -2.68E-01
1328 KIF5B 201991 s at 1.0512E-02 2.55E-04 -3.77 0.32 -3.49E-01
1329 C1orf85 1558693_s_at 1.0558E-02 2.57E-04 -3.77 0.32 -5.60E-01
1330 BCKDHB 213321_at 1.0558E-02 2.57E-04 3.77 0.32 2.17E-01
1331 STX5 203330 s at 1.0558E-02 2.57E-04 -3.77 0.32 -3.28E-01
1332 CX3CR1 205898 at 1.0558E-02 2.57E-04 -3.77 0.32 -5.81 E-01
1333 RPL31 200962 at 1.0560E-02 2.57E-04 3.77 0.31 8.59E-01
1334 PSTK 230129 at 1.0560E-02 2.58E-04 3.77 0.31 3.43E-01
1335 KLF7 1555420 a at 1.0560E-02 2.58E-04 -3.77 0.31 -4.15E-01
1336 228478_at 1.0560E-02 2.58E-04 -3.77 0.31 -4.19E-01
1337 IRAKI 201587_s_at 1.0560E-02 2.58E-04 -3.77 0.31 -3.69E-01
1338 LOC100129 78383_at 1.0571 E-02 2.59E-04 3.77 0.31 4.99E-01 250
1339 BRCC3 216521 _s at 1.0582E-02 2.59E-04 -3.77 0.31 -5.12E-01
1340 FOXRED2 231846 at 1.0582E-02 2.59E-04 -3.77 0.31 -2.58E-01
1341 ADA TS17 1552726 at 1.0625 E-02 2.61 E-04 3.77 0.30 1.60E-01
1342 RAC1 208641 s at 1.0625E-02 2.61 E-04 -3.77 0.30 -3.84E-01
1343 DAP 201095 at 1.0625E-02 2.61 E-04 -3.77 0.30 -4.93E-01
1344 QKI 212262 at 1.0625E-02 2.62E-04 -3.77 0.30 -4.84E-01
1345 NCF2 209949 at 1.0625E-02 2.62E-04 -3.77 0.30 -8.80E-01
1346 234235 at 1.0625E-02 2.62E-04 3.77 0.30 1.22E-01
1347 PTGER1 214391 x at 1.0625E-02 2.62E-04 3.77 0.30 3.71 E-01
1348 ZNF253 242919 at 1.0625E-02 2.62E-04 3.77 0.30 3.60E-01
1349 DHRS4L2/// 218021_at 1.0629E-02 2.62E-04 -3.77 0.30 -3.76E-01 DHRS4
1350 WDR1 210936 at 1.0633E-02 2.63E-04 -3.77 0.30 -1.64E-01
1351 CD59 200985 s at 1.0633E-02 2.63E-04 -3.77 0.30 -4.51 E-01
1352 RAB40C 213466 at 1.0668E-02 2.64E-04 3.77 0.29 2.00E-01
1353 VCAN 211571 s at 1.0706 E-02 2.65E-04 -3.76 0.29 -1.20E+00
1354 233951 at 1.0706E-02 2.65E-04 3.76 0.29 2.61 E-01
1355 TACC1 217437 s at 1.0706 E-02 2.66E-04 -3.76 0.29 -4.26E-01
1356 ARHGDIA 213606 s at 1.0706E-02 2.66E-04 -3.76 0.29 -1.68E-01
1357 236084 at 1.0706E-02 2.66E-04 3.76 0.29 1.70E-01
1358 EIF3D 200005 at 1.0713E-02 2.66E-04 -3.76 0.28 -3.99E-01
1359 LE01 235096 at 1.0716E-02 2.66E-04 -3.76 0.28 -4.44E-01
1360 C1 QB 202953 at 1.0732E-02 2.67E-04 -3.76 0.28 -1.19E+00
1361 CYP1 B1 202434 s at 1.0751 E-02 2.68E-04 -3.76 0.28 -2.80E-01
1362 DHDDS 218547 at 1.0751 E-02 2.68E-04 -3.76 0.28 -2.54E-01
1363 MAP3K6 219278 at 1.0752E-02 2.69E-04 -3.76 0.28 -3.50E-01
1364 ADAP2 222876 s at 1.0752E-02 2.69E-04 -3.76 0.28 -5.73E-01
1365 RB S1 215127 s at 1.0752E-02 2.69E-04 -3.76 0.28 -3.25E-01
1366 BSDC1 222200 s at 1.0752E-02 2.69E-04 -3.76 0.28 -3.18E-01
1367 RNF19B 36564 at 1.0752E-02 2.69E-04 -3.76 0.28 -5.98E-01
1368 RGL1 209568 s at 1.0777E-02 2.70E-04 -3.76 0.27 -4.45E-01
1369 LIMA1 217892 s at 1.0800E-02 2.71 E-04 -3.76 0.27 -4.21 E-01
1370 HSPH1 206976 s at 1.0800E-02 2.71 E-04 -3.76 0.27 -3.52E-01
1371 WDR1 244672 at 1.0800E-02 2.71 E-04 3.76 0.27 2.23E-01
1372 1560156 at 1.0800E-02 2.71 E-04 3.76 0.27 3.87E-01
1373 APLP2 208703 s at 1.0800E-02 2.72E-04 -3.76 0.27 -5.77E-01
1374 NRP1 212298 at 1.0800E-02 2.72E-04 -3.76 0.26 -8.17E-01
1375 VSTM2A 1554530 at 1.0800E-02 2.72E-04 3.76 0.26 1.42E-01
1376 FRMD4A 225168 at 1.0800E-02 2.72E-04 -3.76 0.26 -5.55E-01
1377 229498 at 1.0800E-02 2.72E-04 3.76 0.26 4.94E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
1378 CARS 240983 s at 1.0800E-02 2.72E-04 -3.76 0.26 -4.80E-01
1379 237067 at 1.0800E-02 2.72E-04 3.76 0.26 1.62E-01
1380 YIPF3 216338 s at 1.0800E-02 2.73E-04 -3.76 0.26 -4.97E-01
1381 C8orf59 1555243 x at 1.0800E-02 2.73E-04 3.76 0.26 4.72E-01
1382 ERLEC1 P1 242766 at 1.0815E-02 2.73E-04 3.76 0.26 1.65E-01
1383 ITGAV 202351 at 1.0831 E-02 2.74E-04 -3.75 0.26 -5.62E-01
1384 214349 at 1.0831 E-02 2.74E-04 3.75 0.26 9.66E-01
1385 DAB2 201280 s at 1.0852E-02 2.75E-04 -3.75 0.26 -6.76E-01
1386 C17orf51 238167 at 1.0864E-02 2.75E-04 3.75 0.25 3.06E-01
1387 TKTL1 216370 s at 1.0865E-02 2.76E-04 3.75 0.25 2.11E-01
1388 EPB41 L2 201718 s at 1.0865E-02 2.76E-04 -3.75 0.25 -5.36E-01
1389 LILRB3 210225 x at 1.0876E-02 2.77E-04 -3.75 0.25 -5.03E-01
1390 C17orf57 1553626 a at 1.0876E-02 2.77E-04 3.75 0.25 8.15E-01
1391 FOSL2 225262 at 1.0876E-02 2.77E-04 -3.75 0.25 -5.81 E-01
1392 C2 203052 at 1.0928E-02 2.78E-04 -3.75 0.24 -8.35E-01
1393 211106 at 1.0954E-02 2.79E-04 3.75 0.24 5.75E-01
1394 KDSR 1558279 a at 1.0954E-02 2.79E-04 -3.75 0.24 -3.76E-01
1395 HSPA1 B///H 200799_at 1.0954E-02 2.79E-04 -3.75 0.24 -7.27E-01 SPA1A
1396 SCN1A 1555246 a at 1.0974E-02 2.80E-04 3.75 0.24 1.27E-01
1397 226621 at 1.1000E-02 2.81 E-04 -3.75 0.24 -5.24E-01
1398 NFKB1 209239 at 1.1016E-02 2.82E-04 -3.75 0.23 -5.20E-01
1399 1569597 at 1.1031 E-02 2.82E-04 3.75 0.23 2.62E-01
1400 CCDC102A 232051 at 1.1044E-02 2.83E-04 -3.75 0.23 -2.38E-01
1401 AHSA1 201491 at 1.1050E-02 2.83E-04 -3.75 0.23 -4.91 E-01
1402 CLASP2 238224 at 1.1055E-02 2.83E-04 3.75 0.23 1.37E-01
1403 PHF11 221816 s at 1.1071 E-02 2.84E-04 3.74 0.23 2.94E-01
1404 CLN6 222539 at 1.1 116E-02 2.85E-04 3.74 0.22 1.89E-01
1405 CCND1 208712 at 1.1 118E-02 2.86E-04 -3.74 0.22 -5.11 E-01
1406 1564381 s at 1.1127E-02 2.86E-04 3.74 0.22 2.32E-01
1407 SERPINB6 211474 s at 1.1128E-02 2.86E-04 -3.74 0.22 -3.57E-01
1408 229754 at 1.1139E-02 2.87E-04 3.74 0.22 3.30E-01
1409 DIRC2 226026 at 1.1155E-02 2.87E-04 -3.74 0.22 -5.09E-01
1410 CD300A 217078 s at 1.1162E-02 2.88E-04 -3.74 0.21 -6.29E-01
1411 EIF2B5 1558050 at 1.1 162E-02 2.88E-04 3.74 0.21 1.92E-01
1412 RENBP 206617 s at 1.1186E-02 2.89E-04 -3.74 0.21 -5.30E-01
1413 SFRS12 244287 at 1.1194E-02 2.89E-04 -3.74 0.21 -3.50E-01
1414 NEK6 223159 s at 1.1221 E-02 2.90E-04 -3.74 0.21 -4.57E-01
1415 ZNF747 228856 at 1.1221 E-02 2.90E-04 -3.74 0.21 -2.80E-01
1416 239988 at 1.1222E-02 2.91 E-04 3.74 0.21 3.21 E-01
1417 C12orf73 226927 at 1.1224E-02 2.91 E-04 3.74 0.20 3.99E-01
1418 DCUN1 D2 219116 s at 1.1226E-02 2.91 E-04 3.74 0.20 2.76E-01
1419 FADS1 208962 s at 1.1247E-02 2.92E-04 -3.74 0.20 -5.27E-01
1420 GTPBP8 242685 at 1.1248E-02 2.92E-04 3.74 0.20 1.87E-01
1421 TP53I3 210609 s at 1.1248E-02 2.93E-04 -3.74 0.20 -5.34E-01
1422 SSB 201138 s at 1.1248E-02 2.93E-04 -3.74 0.20 -4.11 E-01
1423 C20orf200 1553205 at 1.1248E-02 2.93E-04 3.74 0.20 2.57E-01
1424 L0XL1 203570 at 1.1248E-02 2.93E-04 -3.74 0.20 -8.32E-01
1425 ANXA2 213503 x at 1.1248E-02 2.93E-04 -3.74 0.20 -4.18E-01
1426 ZDHHC3 218078 s at 1.1248E-02 2.93E-04 -3.74 0.20 -4.40E-01
1427 SAA2 //SAA 208607_s_at 1.1248E-02 2.94E-04 -3.74 0.20 -4.29E-01 1
1428 RPS17 201665 x at 1.1248E-02 2.94E-04 3.74 0.20 2.76E-01
1429 CKAP4 200999 s at 1.1248E-02 2.94E-04 -3.73 0.19 -8.34E-01
1430 MRAS 225185 at 1.1248E-02 2.94E-04 -3.73 0.19 -4.49E-01
1431 213691 at 1.1248E-02 2.94E-04 3.73 0.19 2.67E-01
1432 CCDC34 1553666 at 1.1264E-02 2.95E-04 3.73 0.19 1.44E-01
1433 1557238 s at 1.1274E-02 2.96E-04 3.73 0.19 3.04E-01
1434 APLP2 211404 s at 1.1274E-02 2.96E-04 -3.73 0.19 -5.01 E-01
1435 ZNF702P 206557 at 1.1274E-02 2.96E-04 3.73 0.19 2.53E-01
1436 S IP 230285 at 1.1274E-02 2.96E-04 3.73 0.19 5.27E-01
1437 RAC1 208640 at 1.1274 E-02 2.96E-04 -3.73 0.19 -3.40E-01
1438 237048 at 1.1274E-02 2.97E-04 3.73 0.19 3.40E-01
1439 HLA-DMA 217478 s at 1.1274E-02 2.97E-04 -3.73 0.19 -6.14E-01
1440 FAM83A 239586 at 1.1282 E-02 2.97E-04 3.73 0.19 1.87E-01
1441 AHCYL1 200849 s at 1.1287 E-02 2.97E-04 -3.73 0.18 -4.03E-01
1442 PRKAR2A 225000 at 1.1293E-02 2.98E-04 -3.73 0.18 -3.17E-01
1443 UQCRC1 201903 at 1.1311 E-02 2.99E-04 -3.73 0.18 -5.28E-01
1444 DLEU2U//D 215629 s at 1.1311 E-02 2.99E-04 3.73 0.18 3.79E-01
43
No. Gene* Probe ID** Adj. p value P value t B Log FC
LEU2
1445 241460 at 1.131 1 E-02 2.99E-04 3.73 0.18 3.32E-01
1446 LOC338579 1570474 s at 1.1346E-02 3.00E-04 3.73 0.18 1.61 E-01
1447 EN01 201231 s at 1.1353E-02 3.00E-04 -3.73 0.18 -5.42E-01
1448 EFEMP2 209356 x at 1.1380E-02 3.02E-04 -3.73 0.17 -7.76E-01
1449 N!T1 202891 at 1.1380E-02 3.02E-04 -3.73 0.17 -3.13E-01
1450 CSF2RB 205159 at 1.1380E-02 3.02E-04 -3.73 0.17 -4.45E-01
1451 ATP6V1C1 202872 at 1.1420E-02 3.03E-04 -3.73 0.17 -4.67E-01
1452 LYVE1 220037 s at 1.1420E-02 3.03E-04 -3.73 0.17 -6.22E-01
1453 T OD3 223077 at 1.1420E-02 3.03E-04 -3.73 0.17 -4.69E-01
1454 1570076 at 1.1435E-02 3.04E-04 3.73 0.17 1.21 E-01
1455 POGK 218229 s at 1.1435E-02 3.05E-04 -3.73 0.16 -5.85E-01
1456 MRFAP1 226091 s at 1.1435E-02 3.05E-04 -3.72 0.16 -3.82E-01
1457 WBP4 203598 s at 1.1435E-02 3.05E-04 -3.72 0.16 -3.07E-01
1458 INPP1 202794 at 1.1435E-02 3.05E-04 -3.72 0.16 -3.84E-01
1459 236595 at 1.1435E-02 3.05E-04 3.72 0.16 7.48E-01
1460 PRDXDD1 P 237291 at 1.1435E-02 3.05E-04 3.72 0.16 2.27E-01
1461 1560867 a at 1.1435E-02 3.06E-04 3.72 0.16 1.29E-01
1462 LOC151484 1562689 at 1.1464E-02 3.07E-04 3.72 0.16 2.15E-01
1463 SGSH 35626 at 1.1464E-02 3.07E-04 -3.72 0.16 -3.38E-01
1464 LITAF 1555454 at 1.1483E-02 3.07E-04 -3.72 0.16 -1.29E-01
1465 236568 at 1.1496E-02 3.08E-04 3.72 0.15 1.78E-01
1466 KRAS 1559203 s at 1.1496E-02 3.08E-04 3.72 0.15 1.33E-01
1467 225284 at 1.1496E-02 3.08E-04 -3.72 0.15 -6.85E-01
1468 CDX1 206430 at 1.1498E-02 3.09E-04 3.72 0.15 2.35E-01
1469 ZEB2 235593 at 1.1499E-02 3.09E-04 -3.72 0.15 -6.07E-01
1470 FBXL14 1553682 at 1.1521 E-02 3.10E-04 3.72 0.15 1.73E-01
1471 CLECL1 244413 at 1.1521E-02 3.10E-04 3.72 0.15 9.18E-01
1472 ZBTB47 234338 s at 1.1521 E-02 3.10E-04 3.72 0.15 2.71E-01
1473 FAR1 1558014 s at 1.1521 E-02 3.11 E-04 -3.72 0.15 -3.33E-01
1474 FLJ 10038 205511 at 1.1521 E-02 3.1 E-04 3.72 0.15 2.89E-01
1475 C1QTNF1 220975 s at 1.1521 E-02 3.11 E-04 -3.72 0.14 -3.82E-01
1476 NT5DC2 1556895 a at 1.1521 E-02 3.11 E-04 3.72 0.14 1.58E-01
1477 MSRB3 225790 at 1.1521 E-02 3.11 E-04 -3.72 0.14 -3.11 E-01
1478 SLIT3 203813 s at 1.1531 E-02 3.12E-04 -3.72 0.14 -5.59E-01
1479 T E 161 B 236227 at 1.1531E-02 3.12E-04 3.72 0.14 2.91E-01
1480 ATF7IP2 228381 at 1.1531 E-02 3.12E-04 3.72 0.14 7.13E-01
1481 EIF4G1 208625 s at 1.1564E-02 3.13E-04 -3.72 0.14 -5.86E-01
1482 SCARF1 206995 x at 1.1575E-02 3.14E-04 -3.72 0.14 -2.86E-01
1483 HELB 1552787 at 1.1575E-02 3.14E-04 3.72 0.14 5.00E-01
1484 239049 at 1.1575E-02 3.14E-04 3.72 0.14 4.46E-01
1485 CHRNB2 206635 at 1.1594E-02 3.15E-04 3.72 0.13 2.02E-01
1486 GPR107 21 1977 at 1.1594E-02 3.15E-04 -3.72 0.13 -3.46E-01
1487 RAB6A 201047 x at 1.1630E-02 3.16E-04 -3.71 0.13 -3.56E-01
1488 UBAC1 202151 s at 1.1634E-02 3.17E-04 -3.71 0.13 -4.64E-01
1489 RTEL1///TN 206467_x_at 1.1634E-02 3.17E-04 -3.71 0.13 -4.42E-01 FRSF6B
1490 LOC100131 1557817_a_at 1.1634E-02 3.17E-04 3.71 0.13 2.80E-01 941
1491 KIAA1430 226254 s at 1.1634E-02 3.18E-04 3.71 0.13 2.95E-01
1492 CXCL16 223454 at 1.1634E-02 3.19E-04 -3.71 0.12 -8.66E-01
1493 WARS 200628 s at 1.1634E-02 3.19E-04 -3.71 0.12 -9.36E-01
1494 SERINC1 208671 at 1.1634E-02 3.19E-04 -3.71 0.12 -5.28E-01
1495 US01 201831 s at 1.1634E-02 3.19E-04 -3.71 0.12 -4.36E-01
1496 ZNF709 242028 at 1.1634E-02 3.19E-04 3.71 0.12 4.22E-01
1497 PCDHGA8 210368 at 1.1634E-02 3.19E-04 3.71 0.12 1.82E-01
1498 NRP2 229225 at 1.1634E-02 3. 9E-04 -3.71 0.12 -4.18E-01
1499 PALLD 200897 s at 1.1634E-02 3.20E-04 -3.71 0.12 -4.62E-01
1500 233068 at 1.1634E-02 3.20E-04 3.71 0.12 3.56E-01
1501 OSBPL1A 208158 s at 1.1634E-02 3.20E-04 -3.71 0.12 -3.91 E-01
1502 LILRB2 207697 x at 1.1634E-02 3.20E-04 -3.71 0.12 -8.53E-01
1503 DLEU2 216870 x at 1.1634E-02 3.20E-04 3.71 0.12 3.16E-01
1504 T EM155 230137 at 1.1634E-02 3.20E-04 3.71 0.12 7.76E-01
1505 ARHGDIA 211716 x at 1.1634E-02 3.21 E-04 -3.71 0.12 -5.61 E-01
1506 TNP01 209226 s at 1.1634E-02 3.21 E-04 -3.71 0.12 -4.00E-01
1507 NT5DC4 1560204 at 1.1634E-02 3.21 E-04 3.71 0.12 3.65E-01
1508 MGST1 1565162 s at 1.1645E-02 3.21 E-04 -3.71 0.12 -7.87E-01
1509 CAPRIN1 225340 s at 1.1660E-02 3.22E-04 -3.71 0.11 -2.63E-01
1510 PTRF 208790 s at 1.1660E-02 3.22E-04 -3.71 0.11 -4.35E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
1511 ITGB1 1553530 a at 1.1660E-02 3.22E-04 -3.71 0.11 -5.68E-01
1512 LOC 100287 228231_at 1.1663E-02 3.23E-04 -3.71 0.11 -3.77E-01 081
1513 MS4A6A 224356 x at 1.1664E-02 3.23E-04 -3.71 0.11 -6.73E-01
1514 SAE1 1555618 s at 1.1702E-02 3.24E-04 -3.71 0.11 -6.37E-01
1515 SLC24A4 1568922 at 1.1712E-02 3.25E-04 3.71 0.11 1.59E-01
1516 CLEC11A 211709 s at 1.1766E-02 3.26E-04 -3.71 0.10 -6.22E-01
1517 COL4A1 211980 at 1.1801 E-02 3.28E-04 -3.70 0.10 -7.60E-01
1518 MCOLN2 1555465 at 1.1801 E-02 3.28E-04 -3.70 0.10 -7.31 E-01
1519 C1QA 218232 at 1.1801 E-02 3.28E-04 -3.70 0.10 -1.20E+00
1520 ZNF808///Z 236589_at 1.1801 E-02 3.29E-04 -3.70 0.10 -1.48E-01 NF701
1521 CEACAM5 217291 at 1.1801 E-02 3.29E-04 3.70 0.10 1.82E-01
1522 WDR72 227174 at 1.1801 E-02 3.29E-04 3.70 0.09 1.22E-01
1523 VTHA 242356 at 1.1801 E-02 3.29E-04 3.70 0.09 2.62E-01
1524 1557733 a at 1.1801 E-02 3.30E-04 3.70 0.09 7.07E-01
1525 IDH1 201193 at 1.1801 E-02 3.30E-04 -3.70 0.09 -5.09E-01
1526 PFDN4 205361 s at 1.1801 E-02 3.30E-04 3.70 0.09 6.75E-01
1527 DEGS1 207431 s at 1.1801 E-02 3.30E-04 -3.70 0.09 -6.63E-01
1528 EIF4EBP1 221539 at 1.1801 E-02 3.30E-04 -3.70 0.09 -4.29E-01
1529 SLC8A1 241752 at 1.1801 E-02 3.30E-04 -3.70 0.09 -3.64E-01
1530 ACTA2 200974 at 1.1844E-02 3.32E-04 -3.70 0.09 -9.29E-01
1531 240533 at 1.1844E-02 3.32E-04 3.70 0.09 1.34E-01
1532 LRRC41 201932 at 1.1883E-02 3.33E-04 -3.70 0.08 -4.04E-01
1533 ID1 208937 s at 1.1897E-02 3.34E-04 -3.70 0.08 -6.50E-01
1534 STK17B 217503 at 1.1910E-02 3.34E-04 3.70 0.08 5.54E-01
1535 TPP1 200742 s at 1.1918E-02 3.35E-04 -3.70 0.08 -9.86E-01
1536 231272 at 1.1918E-02 3.35E-04 3.70 0.08 1.96E-01
1537 DRAM1 218627 at 1.1918E-02 3.35E-04 -3.70 0.08 -6.00E-01
1538 LOC100131 231497_at 1.1918E-02 3.35E-04 3.70 0.08 1.97E-01 117
1539 CCNY 224652 at 1.1918E-02 3.36E-04 -3.70 0.08 -2.90E-01
1540 EIF3J 217364 x at 1.1918E-02 3.36E-04 -3.70 0.08 -2.05E-01
1541 ARMCX3 217858 s at 1.1918E-02 3.36E-04 -3.70 0.08 -3.83E-01
1542 GPX3 214091 s at 1.1940E-02 3.37E-04 -3.70 0.07 -9.67E-01
1543 GOLGA3 202106 at 1.1953E-02 3.37E-04 -3.70 0.07 -3.58E-01
1544 C3orf16 1561928_s_at 1.1976E-02 3.38E-04 3.70 0.07 1.63E-01
1545 CKAP4 200998 s at 1.1976E-02 3.38E-04 -3.70 0.07 -8.33E-01
1546 EIF2S3 205321 at 1.1983E-02 3.39E-04 3.69 0.07 7.57E-01
1547 TFCP2 207627 s at 1.1983E-02 3.39E-04 -3.69 0.07 -3.52E-01
1548 PPP5C 201979 s at 1.1983E-02 3.39E-04 -3.69 0.07 -3.17E-01
1549 ANXA4 201301 s at 1.1985E-02 3.40E-04 -3.69 0.07 -4.69E-01
1550 SHC1 201469 s at 1.2021 E-02 3.41 E-04 -3.69 0.06 -3.45E-01
1551 GGPS1 202322 s at 1.2021 E-02 3.41 E-04 3.69 0.06 3.14E-01
1552 TFE3 206649 s at 1.2021 E-02 3.41 E-04 -3.69 0.06 -3.60E-01
1553 SEC61A1 217716 s at 1.2021 E-02 3.41 E-04 -3.69 0.06 -4.12E-01
1554 216146 at 1.2021 E-02 3.42E-04 3.69 0.06 1.41 E-01
1555 WBSCR16 221247 s at 1.2021 E-02 3.42E-04 -3.69 0.06 -3.59E-01
1556 DCN 211896 s at 1.2027E-02 3.42E-04 -3.69 0.06 -1.49E+00
1557 PCYOX1 225274 at 1.2030E-02 3.43E-04 -3.69 0.06 -5.24E-01
1558 TBC1 D9B 215994 x at 1.2032E-02 3.43E-04 -3.69 0.06 -3.80E-01
1559 VAMP3 201336 at 1.2033E-02 3.43E-04 -3.69 0.06 -3.12E-01
1560 NUDT16 235054 at 1.2033E-02 3.44E-04 -3.69 0.06 -3.72E-01
1561 NPM1 200063 s at 1.2033E-02 3.44E-04 3.69 0.05 1.55E-01
1562 1557712 x at 1.2033E-02 3.44E-04 3.69 0.05 2.41 E-01
1563 233976 at 1.2033E-02 3.44E-04 3.69 0.05 1.93E-01
1564 SLC11A1 210423 s at 1.2033E-02 3.44E-04 -3.69 0.05 -3.84E-01
1565 CHRNA3 211772 x at 1.2033E-02 3.45E-04 3.69 0.05 1.25E-01
1566 ASPH 209135 at 1.2033E-02 3.45E-04 -3.69 0.05 -4.28E-01
1567 231013 at 1.2033E-02 3.45E-04 3.69 0.05 6.39E-01
1568 KARS 200079 s at 1 2033E-02 3.45E-04 -3.69 0.05 -4.36E-01
1569 SPATS2L 222154 s at 1.2033E-02 3.45E-04 -3.69 0.05 -4.12E-01
1570 ABCA4 210082 at 1.2042E-02 3.46E-04 3.69 0.05 2.13E-01
1571 LOC643955/ 1554996_at 1.2042E-02 3.47E-04 3.69 0.05 1.20E-01 //ZNF727///Z
NF479
1572 PI4K2A 209346 s at 1.2042E-02 3.47E-04 -3.69 0.05 -2.70E-01
1573 GAUMS 206335 at 1.2042E-02 3.47E-04 -3.69 0.05 -3.83E-01
1574 EIF3M 202231 at 1.2042E-02 3.47E-04 3.69 0.05 2.54E-01
No. Gene* Probe ID** Adj. p value P value ί B Log FC
1575 FH 203032_s_at 1.2042E-02 3.47E-04 -3.69 0.05 -2.43E-01
1576 COQ7 209746 s at 1.2042E-02 3.47E-04 3.69 0.05 2.63E-01
1577 COL4A2 211966 at 1.2042E-02 3.47E-04 -3.69 0.05 -8.52E-01
1578 ALOX5 214366 s at 1.2047E-02 3.48E-04 -3.69 0.05 -6.47E-01
1579 SQSTM1 201471 s at 1.2054E-02 3.48E-04 -3.69 0.04 -4.96E-01
1580 SNHG10 244786 at 1.2088E-02 3.49E-04 3.69 0.04 4.22E-01
1581 SELS 223209_s_at 1.2100E-02 3.50E-04 -3.69 0.04 -3.99E-01
1582 NDUFC1 203478 at 1.2119E-02 3.51 E-04 3.69 0.04 3.20E-01
1583 COPZ1 222386 s at 1.2119E-02 3.51 E-04 -3.68 0.04 -4.94E-01
1584 237275_at 1.2123E-02 3.51 E-04 3.68 0.04 1.42E-01
1585 HLA-G 211528_x at 1.2123E-02 3.51 E-04 -3.68 0.04 -4.70E-01
1586 NRP2 214632 at 1.2143E-02 3.52E-04 -3.68 0.03 -2.75E-01
1587 KLF3 222913 at 1.2143E-02 3.52E-04 -3.68 0.03 -1.95E-01
1588 AGGF1 208042_at 1.2170E-02 3.53E-04 -3.68 0.03 -3.90E-01
1589 PSMA3 232648 at 1.2177E-02 3.54E-04 3.68 0.03 3.17E-01
1590 PFDN6 242048_at 1.2179E-02 3.54E-04 3.68 0.03 1.98E-01
1591 AC02 200793 s at 1.2179E-02 3.54E-04 -3.68 0.03 -4.99E-01
1592 LOC391020 216565 x at 1.2231E-02 3.56E-04 -3.68 0.02 -3.79E-01
1593 SSBP1 1562442 a at 1.2231 E-02 3.56E-04 3.68 0.02 2.78E-01
1594 243221 at 1.2254E-02 3.57E-04 -3.68 0.02 -3.91 E-01
1595 TK2 204227 s at 1.2275E-02 3.58E-04 -3.68 0.02 -2.72E-01
1596 C0MMD4 209133 s at 1.2288E-02 3.59E-04 3.68 0.02 1.98E-01
1597 RPS21 200834 s at 1.2294E-02 3.59E-04 3.68 0.02 3.13E-01
1598 1564129 a at 1.2294E-02 3.59E-04 3.68 0.02 2.24E-01
1599 RPL7AP12// 234807_x_at 1.2311 E-02 3.60E-04 3.68 0.01 3.63E-01 /RPS4XP2
1600 TCERG1 238838 at 1.2311 E-02 3.60E-04 3.68 0.01 1.32E-01
1601 Y07A 33197 at 1.2318E-02 3.61 E-04 -3.68 0.01 -4.97E-01
1602 CLLU1 1558185 at 1.2318E-02 3.61 E-04 3.68 0.01 9.36E-01
1603 PDE3B 222317 at 1.2318E-02 3.61 E-04 3.68 0.01 5.15E-01
1604 PEPD 202108 at 1.2318E-02 3.61 E-04 -3.68 0.01 -3.32E-01
1605 HIST1 H2AB/ 214469_at 1.2339E-02 3.62E-04 3.68 0.01 6.56E-01
//HIST1H2A
E
1606 EEA1 225885 at 1.2339E-02 3.62E-04 -3.68 0.01 -4.05E-01
1607 SLC03A1 227367 at 1.2355E-02 3.63E-04 -3.67 0.01 -5.08E-01
1608 NT5C2 236703 at 1.2355E-02 3.63E-04 3.67 0.01 3.21 E-01
1609 43511 s at 1.2412E-02 3.65E-04 -3.67 0.00 -2.98E-01
1610 CCL18 209924 at 1.2454E-02 3.67E-04 -3.67 0.00 -1.06E+00
1611 GTPBP1 205274 at 1.2467E-02 3.67E-04 3.67 0.00 1.89E-01
1612 UBFD1 205687 at 1.2516E-02 3.69E-04 -3.67 -0.01 -3.60E-01
1613 1561546 at 1.2536E-02 3.70E-04 3.67 -0.01 2.17E-01
1614 AK1 202588 at 1.2556E-02 3.71 E-04 3.67 -0.01 2.28E-01
1615 HLA-B 208729 x at 1.2556E-02 3.71 E-04 -3.67 -0.01 -6.06E-01
1616 240508 at 1.2556E-02 3.71 E-04 3.67 -0.01 1.82E-01
1617 N4BP1 32069 at 1.2587E-02 3.72E-04 -3.67 -0.02 -3.51 E-01
1618 229074 at 1.2587E-02 3.72E-04 -3.67 -0.02 -5.58E-01
1619 ATP5B 201322 at 1.2587E-02 3.73E-04 -3.67 -0.02 -4.28E-01
1620 NCR3 211583 x at 1.2605E-02 3.73E-04 3.67 -0.02 2.53E-01
1621 0DZ3 227050 at 1.2606E-02 3.74E-04 3.67 -0.02 1.86E-01
1622 GNS 203676 at 1.2606E-02 3.74E-04 -3.67 -0.02 -6.53E-01
1623 NNMT 202238 s at 1.2606E-02 3.74E-04 -3.67 -0.02 -8.82E-01
1624 TNS3 217853 at 1.2606E-02 3.74E-04 -3.67 -0.02 -5.66E-01
1625 ARHGEF19 226857 at 1.2614E-02 3.75E-04 -3.67 -0.02 -2.42E-01
1626 1561065 at 1.2614E-02 3.75E-04 3.67 -0.02 2.64E-01
1627 NBL1 201621 at 1.2614E-02 3.75E-04 -3.67 -0.02 -6.51 E-01
1628 TSPO 202096 s at 1.2621 E-02 3.76E-04 -3.66 -0.03 -5.02E-01
1629 TMED9 205812 s at 1.2621 E-02 3.76E-04 -3.66 -0.03 -4.56E-01
1630 SLC04A1 229239 x at 1.2621 E-02 3.77E-04 3.66 -0.03 1.98E-01
1631 SRCAP 1552630 a at 1.2621 E-02 3.77E-04 3.66 -0.03 1.64E-01
1632 LN 207473 at 1.2621 E-02 3.77E-04 3.66 -0.03 1.79E-01
1633 FAIM 220643 s at 1.2621 E-02 3.77E-04 -3.66 -0.03 -5.01 E-01
1634 1564887 at 1.2646E-02 3.78E-04 3.66 -0.03 1.43E-01
1635 PAX3 207680 x at 1.2650E-02 3.78E-04 3.66 -0.03 2.17E-01
1636 234827 at 1.2657E-02 3.79E-04 3.66 -0.03 1.42E-01
1637 AGGF1 218534 s at 1.2657E-02 3.79E-04 -3.66 -0.03 -4.25E-01
1638 FCF1 240928 at 1.2753E-02 3.82E-04 3.66 -0.04 2.42E-01
1639 ITFG1 221449 s at 1.2753E-02 3.82E-04 -3.66 -0.04 -5.03E-01
1640 228498_at 1.2761E-02 3.83E-04 -3.66 -0.04 -5.34E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
1641 DCTN4 218013 x at 1.2774E-02 3.83E-04 -3.66 -0.04 -4.07E-01
1642 EIF3 215190 at 1.2795E-02 3.84E-04 3.66 -0.04 4.39E-01
1643 PLP2 201136 at 1.2802E-02 3.85E-04 -3.66 -0.05 -5.36E-01
1644 HLA-B 21191 1 x at 1.2804E-02 3.85E-04 -3.66 -0.05 -6.25E-01
1645 233661 at 1.2814E-02 3.86E-04 3.66 -0.05 1.50E-01
1646 SH2B3 203320 at 1.2835E-02 3.87E-04 -3.66 -0.05 -5.13E-01
1647 CBX5 242069 at 1.2835E-02 3.87E-04 3.66 -0.05 4.45E-01
1648 METTL8 1554667 s at 1.2835E-02 3.87E-04 3.66 -0.05 5.89E-01
1649 1555616 at 1.2841 E-02 3.87E-04 3.66 -0.05 2.38E-01
1650 COL5A2 221730 at 1.2862E-02 3.88E-04 -3.66 -0.05 -1.23E+00
1651 Y01 C 225080 at 1.2862E-02 3.88E-04 -3.66 -0.05 -5.26E-01
1652 BLVRA 211729_x_at 1.2878E-02 3.89E-04 -3.66 -0.06 -3.87E-01
1653 244498_x_at 1.2899E-02 3.90E-04 3.65 -0.06 2.09E-01
1654 240742 at 1.2899E-02 3.90E-04 3.65 -0.06 1.81E-01
1655 P S2L1 216843 x at 1.2899E-02 3.90E-04 3.65 -0.06 3.99E-01
1656 LILRA2 21 1101 x at 1.2907E-02 3.91 E-04 -3.65 -0.06 -2.82E-01
1657 HUS1 B 1553660 at 1.2931E-02 3.92E-04 3.65 -0.06 1.48E-01
1658 CNTD1 231463 at 1.2931E-02 3.92E-04 3.65 -0.06 1.79E-01
1659 LOC440944 232052_at 1.2937E-02 3.93E-04 3.65 -0.06 4.50E-01
1660 PI4K2A 209345_s_at 1.2952E-02 3.93E-04 -3.65 -0.06 -5.98E-01
1661 LOC100133 204670_x_at 1.2966E-02 3.94E-04 -3.65 -0.07 -5.41 E-01
811///LOC10
0133661 WZ
NF749///RN
ASE2///HLA-
DRB5///HLA
DRB4///HLA
DRB3///HLA
DRB2///HLA
-DRB1
1662 RB 15 219286 s at 1.2967E-02 3.94E-04 3.65 -0.07 2.98E-01
1663 C6orf105 215100 at 1.2968E-02 3.95E-04 3.65 -0.07 3.29E-01
1664 P2RY13 220005 at 1.2968E-02 3.95E-04 -3.65 -0.07 -8.44E-01
1665 P2RX4 204088 at 1.2968E-02 3.95E-04 -3.65 -0.07 -6.67E-01
1666 RSBN1 L 226387 at 1.3017E-02 3.97E-04 3.65 -0.07 4.12E-01
1667 244749 at 1.3017E-02 3.97E-04 3.65 -0.07 1.76E-01
1668 NCRNA001 244807_at 1.3079E-02 3.99E-04 3.65 -0.08 1.38E-01 88
1669 IDH3B 210418 s at 1.3095E-02 4.00E-04 -3.65 -0.08 -4.79E-01
1670 CXorf65 231377 at 1.3095E-02 4.00E-04 3.65 -0.08 4.46E-01
1671 217152 at 1.3100E-02 4.00E-04 3.65 -0.08 2.55E-01
1672 230761 at 1.3100E-02 4.01 E-04 3.65 -0.08 3.62E-01
1673 LOC728485 242070 at 1.3109E-02 4.01 E-04 3.65 -0.08 2.21 E-01
1674 S4A1 231418 at 1.3109E-02 4.01 E-04 3.65 -0.08 1.05E+00
1675 FA 20A 241981 at 1.3115E-02 4.02E-04 -3.65 -0.08 -5.78E-01
1676 IP07 200992 at 1.3116E-02 4.02E-04 -3.65 -0.08 -3.84E-01
1677 240655 at 1.3116E-02 4.02E-04 3.65 -0.09 2.15E-01
1678 TI P3 201150 s at 1.3119E-02 4.03E-04 -3.65 -0.09 -8.76E-01
1679 235856 at 1.3119E-02 4.03E-04 -3.65 -0.09 -2.82E-01
1680 SLC15A3 219593 at 1.3119E-02 4.03E-04 -3.65 -0.09 -7.26E-01
1681 PATL1 235234 at 1.3119E-02 4.03E-04 -3.64 -0.09 -2.30E-01
1682 BRPF3 225217 s at 1.3119E-02 4.04E-04 -3.64 -0.09 -2.72E-01
1683 232111 at 1.3124E-02 4.04E-04 3.64 -0.09 1.53E-01
1684 RERG 244745 at 1.3133E-02 4.05E-04 -3.64 -0.09 -2.78E-01
1685 TUBA1A 209118 s at 1.3151 E-02 4.05E-04 -3.64 -0.09 -2.81 E-01
1686 DGCR2 227028 s at 1.3176E-02 4.06E-04 3.64 -0.09 2.08E-01
1687 DDAH2 215537 x at 1.3187E-02 4.07E-04 -3.64 -0.10 -4.27E-01
1688 SLC25A43 155741 1 s at 1.3187E-02 4.07E-04 -3.64 -0.10 -5.10E-01
1689 RAB2A 208730 x at 1.3187E-02 4.07E-04 3.64 -0.10 2.48E-01
1690 MFI2 220043 s at 1.3191E-02 4.08E-04 3.64 -0.10 2.01 E-01
1691 RPS17 211487 x at 1.3200E-02 4.08E-04 3.64 -0.10 2.50E-01
1692 DNPEP 201937 s at 1.3200E-02 4.09E-04 -3.64 -0.10 -5.19E-01
1693 SCAMP3 201771 at 1.3200E-02 4.09E-04 -3.64 -0.10 -3.41 E-01
1694 LOC541471/ 225799_at 1.3200E-02 4.09E-04 3.64 -0.10 5.63E-01
//NCRNA00
152
1695 ALB 214837 at 1.3200E-02 4.09E-04 3.64 -0.10 1.11E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
1747 RBPJ 211974 x at 1.3576E-02 4.34E-04 -3.62 -0.15 -4.44E-01
1748 ADAP2 219358 s at 1.3576E-02 4.34E-04 -3.62 -0.15 -5.20E-01
1749 244827 at 1.3596E-02 4.35E-04 -3.62 -0.16 -1.53E-01
1750 1562314 at 1.3596E-02 4.35E-04 3.62 -0.16 2.24E-01
1751 HSPD1 200806 s at 1.3596E-02 4.35E-04 -3.62 -0.16 -5.85E-01
1752 BRAF 243829 at 1.3613E-02 4.36E-04 3.62 -0.16 3.76E-01
1753 HSP90AB1 200064 at 1.3616E-02 4.37E-04 -3.62 -0.16 -6.17E-01
1754 LLGL2 1554006 a at 1.3618E-02 4.37E-04 3.62 -0.16 1.58E-01
1755 LRRC28 1553940 a at 1.3618E-02 4.38E-04 -3.62 -0.16 -2.09E-01
1756 PHLDA2 209803 s at 1.3618E-02 4.38E-04 -3.62 -0.16 -5.00E-01
1757 240489 at 1.3618E-02 4.38E-04 3.62 -0.16 1.32E-01
1758 C10orf110 220703 at 1.3618 E-02 4.38E-04 3.62 -0.16 1.42E-01
1759 1560779_a_at 1.3627E-02 4.38E-04 3.62 -0.16 1.37E-01
1760 DLG5 201681 s at 1.3701 E-02 4.41 E-04 -3.62 -0.17 -5.14E-01
1761 ZNF280D 1568951_at 1.3701 E-02 4.41 E-04 3.62 -0.17 2.50E-01
1762 PEX19 201706 s at 1.3721 E-02 4.42E-04 -3.62 -0.17 -3.66E-01
1763 FCN1 205237 at 1.3721 E-02 4.42E-04 -3.62 -0.17 -8.38E-01
1764 GART 217445 s at 1.3721 E-02 4.43E-04 -3.62 -0.17 -2.14E-01
1765 PRLR 211917 s at 1.3766E-02 4.44E-04 3.62 -0.17 9.36E-02
1766 GORASP1 215749 s at 1.3766E-02 4.45E-04 -3.62 -0.17 -4.64E-01
1767 TBC1 D9B 212054 x at 1.3766E-02 4.45E-04 -3.62 -0.18 -3.45E-01
1768 LOC283028 1560744 at 1.3773E-02 4.45 E-04 3.62 -0.18 1.77E-01
1769 LOC440944 1555858 at 1.3782 E-02 4.46E-04 3.62 -0.18 3.62E-01
1770 HSPB1 201841 s at 1.3818E-02 4.47E-04 -3.62 -0.18 -5.81 E-01
1771 LYPD3 204952 at 1.3829E-02 4.48E-04 -3.61 -0.18 -3.15E-01
1772 228918 at 1.3837E-02 4.49E-04 -3.61 -0.18 -4.72E-01
1773 TMED10 212352 s at 1.3837E-02 4.49E-04 -3.61 -0.18 -3.33E-01
1774 PCDHGA1/// 215836_s_at 1.3837 E-02 4.49E-04 -3.61 -0.18 -3.96E-01
PCDHGA2///
PCDHGA3///
PCDHGA4///
PCDHGA5///
PCDHGA6///
PCDHGA7///
PCDHGA9///
PCDHGA10/
//PCDHGA1
1///PCDHGB
1///PCDHGB
2///PCDHGB
3///PCDHGB
5///PCDHGB
6///PCDHGB
7///PCDHGC
4///PCDHGC
5///PCDHGA
12///PCDHG
A8///PCDHG
B4///PCDHG
C3
1775 ARF1 208750 s at 1.3838E-02 4.49E-04 -3.61 -0.18 -7.02E-01
1776 GATA6 229282 at 1.3873E-02 4.51 E-04 3.61 -0.19 2.47E-01
1777 LRCH3 1559490 at 1.3913E-02 4.52E-04 3.61 -0.19 4.13E-01
1778 SAP18 208741 at 1.3913E-02 4.53E-04 -3.61 -0.19 -3.28E-01
1779 MTRF1 219822 at 1.3913E-02 4.53E-04 3.61 -0.19 4.73E-01
1780 C14orf178 1564816 at 1.3913E-02 4.53E-04 3.61 -0.19 1.65E-01
1781 CYB5R3 1554574 a at 1.3916E-02 4.53E-04 -3.61 -0.19 -4.38E-01
1782 C10orf84 222617 s at 1.3948E-02 4.55E-04 3.61 -0.19 4.16E-01
1783 215738 at 1.3948E-02 4.55E-04 3.61 -0.20 1.66E-01
1784 215304 at 1.3968E-02 4.56E-04 3.61 -0.20 1.59E-01
1785 HDLBP 221767 x at 1.3968E-02 4.56E-04 -3.61 -0.20 -4.97E-01
1786 MIB2 241541 at 1.3999E-02 4.57E-04 3.61 -0.20 2.09E-01
1787 229629 at 1.4001 E-02 4.58E-04 3.61 -0.20 4.75E-01
1788 ALDH1A3 203180 at 1.4001 E-02 4.58E-04 -3.61 -0.20 -1.04E+00
1789 ZSCA 12 206507 at 1.4006E-02 4.58E-04 3.61 -0.20 2.86E-01
1790 RGS5 1555725 a at 1.4012E-02 4.59E-04 -3.61 -0.20 -5.47E-01
1791 TAGLN2 210978 s at 1.4012E-02 4.59E-04 -3.61 -0.20 -7.37E-01
1792 NCRNA001 1561127_at 1.4015E-02 4.59E-04 3.61 -0.20 1.68E-01 68
1793 PIK3R6 1558770 a at 1.4015E-02 4.60E-04 -3.61 -0.20 -3.64E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
1794 TBXA2R 21 1590 x at 1.4029E-02 4.60E-04 -3.61 -0.21 -1.89E-01
1795 OFD1 241751 at 1.4035E-02 4.61 E-04 3.61 -0.21 3.06E-01
1796 DDR2 227561 at 1.4049E-02 4.61 E-04 -3.61 -0.21 -5.47E-01
1797 GPI 208308 s at 1.4074E-02 4.63E-04 -3.61 -0.21 -6.29E-01
1798 233629 at 1.4074E-02 4.63E-04 3.61 -0.21 1.47E-01
1799 PDHA1 200979 at 1.4074E-02 4.63E-04 -3.61 -0.21 -3.03E-01
1800 1560579 s at 1.4074E-02 4.63E-04 3.61 -0.21 2.24E-01
1801 243493 at 1.4089E-02 4.64E-04 3.60 -0.21 1.92E-01
1802 AC01 207071 s at 1.4090E-02 4.64E-04 -3.60 -0.21 -4.53E-01
1803 ERLIN1 202444 s at 1.4122E-02 4.66E-04 -3.60 -0.22 -3.50E-01
1804 ICAM1 202637 s at 1.4122E-02 4.66E-04 -3.60 -0.22 -6.08E-01
1805 TBC1 D7 1563839 at 1.4139E-02 4.67E-04 3.60 -0.22 1.10E-01
1806 241271 at 1.4167E-02 4.68E-04 3.60 -0.22 9.90E-02
1807 FAM169A 213954 at 1.4172E-02 4.68E-04 3.60 -0.22 2.46E-01
1808 ZNF639 222624 s at 1.4199E-02 4.70E-04 3.60 -0.22 3.81E-01
1809 EFEMP1 201842 s at 1.4221E-02 4.71 E-04 -3.60 -0.23 -9.02E-01
1810 ZEB2 203603 s at 1.422 E-02 4.71 E-04 -3.60 -0.23 -5.54E-01
1811 SDF4 217855 x at 1.4277E-02 4.73E-04 -3.60 -0.23 -4.01 E-01
1812 FTH1 200748_s_at 1.4303E-02 4.74E-04 -3.60 -0.23 -6.12E-01
1813 ADAM9 1555326 a at 1.4327E-02 4.75E-04 -3.60 -0.23 -4.83E-01
1814 236520 at 1.4327E-02 4.75E-04 3.60 -0.23 2.00E-01
1815 NBR1 201383 s at 1.4347E-02 4.76E-04 -3.60 -0.24 -4.82 E-01
1816 IQGAP1 200791 s at 1.4347E-02 4.77E-04 -3.60 -0.24 -3.04E-01
1817 MAN2C1 238089 at 1.4347E-02 4.77E-04 3.60 -0.24 2.69E-01
1818 NRF1 211279 at 1.4347E-02 4.77E-04 3.60 -0.24 1 .99E-01
1819 UBE2Q1 222480 at 1.4347E-02 4.78E-04 -3.60 -0.24 -2.91 E-01
1820 PPARD 242218 at 1.4347E-02 4.78E-04 3.60 -0.24 1.86E-01
1821 CSDE1 222975 s at 1.4347E-02 4.78E-04 -3.60 -0.24 -4.85E-01
1822 GPKOW 203776 at 1.4347E-02 4.79E-04 -3.60 -0.24 -3.68E-01
1823 PPM1 N 229559 at 1.4347E-02 4.79E-04 -3.60 -0.24 -3.44E-01
1824 GART 212378 at 1.4347E-02 4.79E-04 -3.60 -0.24 -4.36E-01
1825 GINS4 240778 at 1.4347E-02 4.79E-04 3.60 -0.24 1.47E-01
1826 SNAPC2 204104 at 1.4347E-02 4.79E-04 -3.60 -0.24 -2.59E-01 827 CD99L2 223041 at 1.4347E-02 4.79E-04 -3.60 -0.24 -3.55E-01
1828 229006_at 1.4351 E-02 4.80E-04 3.59 -0.24 1.72E-01
1829 KLF6 208960 s at 1.4371E-02 4.81 E-04 -3.59 -0.24 -6.95E-01
1830 KCNJ2 231513 at 1.4407E-02 4.83E-04 -3.59 -0.25 -9.12E-01
1831 AFFX- 1.4407E-02 4.83E-04 -3.59 -0.25 -6.29E-01
HUMGAPDH/M3319
GAPDH 7 M at
1832 LYVE1 219059 s at 1.4407E-02 4.83E-04 -3.59 -0.25 -8.79E-01
1833 237763 at 1.4407E-02 4.83E-04 3.59 -0.25 1.88E-01
1834 TFB1 M 228075 x at 1.4429E-02 4.84E-04 3.59 -0.25 4.27E-01
1835 222296 at 1.4448E-02 4.85E-04 -3.59 -0.25 -2.06E-01
1836 TMPRSS6 214955 at 1.4448E-02 4.86E-04 3.59 -0.25 1.67E-01
1837 VIPAR 233140 s at 1.4448E-02 4.86E-04 -3.59 -0.25 -2.20E-01
1838 ZNF358 226260 x at 1.4448E-02 4.86E-04 3.59 -0.25 2.26E-01
1839 CD97 202910 s at 1.4450E-02 4.86E-04 -3.59 -0.25 -4.32E-01
1840 RPL36 219762 s at 1.4467E-02 4.87E-04 3.59 -0.26 4.22E-01
1841 ZEB2 228333 at 1.4502E-02 4.88E-04 -3.59 -0.26 -3.93E-01
1842 SRPX 204955 at 1.4511 E-02 4.89E-04 -3.59 -0.26 -1.14E+00
1843 CTTN 227473 at 1.4511 E-02 4.89E-04 -3.59 -0.26 -4.34E-01
1844 238796 at 1.4522E-02 4.90E-04 3.59 -0.26 3.36E-01
1845 AIM1 212543 at 1.4543E-02 4.91 E-04 -3.59 -0.26 -4.36E-01
1846 CAPRIN1 200723 s at 1.4553E-02 4.91 E-04 -3.59 -0.26 -4.64E-01
1847 ERI1 226416 at 1.4564E-02 4.92E-04 -3.59 -0.27 -5.04E-01
1848 BCAS4 228787 s at 1.4564E-02 4.93E-04 3.59 -0.27 3.51 E-01
1849 NECAP2 220731 s at 1.4564E-02 4.93E-04 -3.59 -0.27 -3.05E-01
1850 FAM109B 226504 at 1.4564E-02 4.93E-04 -3.59 -0.27 -3.15E-01
1851 PRPF40A 213729 at 1.4586E-02 4.94E-04 -3.59 -0.27 -5.47E-01
1852 WHAMML2// 1560662_s_at 1.4586E-02 4.94E-04 3.59 -0.27 1.28E-01
/HAMML1
1853 HAPLN2 220142 at 1.4588E-02 4.94E-04 3.59 -0.27 1.54 E-01
1854 GEMIN4 217099 s at 1.4594E-02 4.95E-04 -3.59 -0.27 -3.26E-01
1855 MTHFD1 202309 at 1.4598E-02 4.95E-04 -3.59 -0.27 -3.99E-01
1856 238243 at 1.4602E-02 4.96E-04 3.59 -0.27 1.90E-01
1857 CCND2 200951 s at 1.4609E-02 4.96E-04 -3.59 -0.27 -6.07E-01
1858 SECTM1 213716 s at 1.4621 E-02 4.97E-04 -3.58 -0.27 -6.76E-01
1859 TDH 1553493 a at 1.4624E-02 4.97E-04 3.58 -0.27 2.94E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
1924 TAAR5 221459 at 1.5543E-02 5.47E-04 3.56 -0.36 1.76E-01
1925 GK 215977 x at 1.5543E-02 5.47E-04 -3.56 -0.36 -5.61 E-01
1926 DNAJC3 208499 s at 1.5556E-02 5.48E-04 -3.56 -0.36 -3.39E-01
1927 ARSF 214490 at 1.5556E-02 5.49E-04 3.56 -0.36 2.12E-01
1928 LOC100128 217353_at 1.5556E-02 5.49E-04 -3.56 -0.36 -1.72E-01
836///LOC73
0246///LOC7
29366///LOC
729102///LO
C728732///L
OC728643///
LOC728170/
//HNRPA1 P
5///HNRPA1
L-
2///LOC6450
01///LOC644
037///LOC64
2817///LOC4
40125///LOC
402112//Λ.Ο
C391670///H
NRNPA1 L2//
/LOC120364
///HNRNPA1
1929 LGALS3BP 200923 at 1.5556E-02 5.49E-04 -3.56 -0.36 -9.13E-01
1930 FA 101A 227320 at 1.5556E-02 5.49E-04 -3.56 -0.36 -3.68E-01
1931 CST3 201360 at 1.5563E-02 5.50E-04 -3.56 -0.36 -7.82E-01
1932 TI P3 201149 s at 1.5577E-02 5.50E-04 -3.55 -0.37 -8.54E-01
1933 ARSA 204443 at 1.5579E-02 5.51 E-04 -3.55 -0.37 -4.58E-01
1934 LRP1 200785 s at 1.5583E-02 5.51 E-04 -3.55 -0.37 -3.06E-01
1935 LAMB1 201505 at 1.5583E-02 5.51 E-04 -3.55 -0.37 -8.93E-01
1936 ADCK2 221893 s at 1.5603E-02 5.52E-04 -3.55 -0.37 -5.39E-01
1937 LOC100129 244175_at 1.5606E-02 5.53E-04 3.55 -0.37 2.07E-01 852
1938 psiTPTE22 243952 at 1.5654E-02 5.55E-04 3.55 -0.37 1.45E-01
1939 CDH10 220115 s at 1.5654E-02 5.55E-04 3.55 -0.37 1.19E-01
1940 SCA P5 234568 at 1.5654E-02 5.55E-04 3.55 -0.37 2.51 E-01
1941 ATN1 206904 at 1.5655E-02 5.56E-04 3.55 -0.37 1.57E-01
1942 DNAJB1 200664 s at 1.5655E-02 5.56E-04 -3.55 -0.37 -4.42E-01
1943 232903 at 1.5660E-02 5.57E-04 -3.55 -0.38 -1.62E-01
1944 SST 213921 at 1.5665E-02 5.57E-04 3.55 -0.38 1.40E-01
1945 MSN 200600 at 1.5671 E-02 5.57E-04 -3.55 -0.38 -6.24E-01
1946 GALNT2 217788 s at 1.5693E-02 5.59E-04 -3.55 -0.38 -5.42E-01
1947 CDC42EP1 204693 at 1.5693E-02 5.59E-04 -3.55 -0.38 -3.17E-01
1948 PAPOLG 224427 s at 1.5739E-02 5.61 E-04 3.55 -0.38 2.78E-01
1949 TNS1 221246 x at 1.5739E-02 5.61 E-04 -3.55 -0.38 -3.84E-01
1950 FAM104B 227869 at 1.5747E-02 5.62E-04 3.55 -0.38 3.90E-01
1951 1 561272 at 1.5760E-02 5.62E-04 3.55 -0.38 1.24E-01
1952 232956 at 1.5760E-02 5.63E-04 3.55 -0.38 1.37E-01
1953 SUSD4 223821 s at 1.5760E-02 5.63E-04 3.55 -0.39 1.26E-01
1954 ACE 209749 s at 1.5760E-02 5.63E-04 -3.55 -0.39 -1.64E-01
1955 4911 1 at 1.5760E-02 5.64E-04 -3.55 -0.39 -2.46E-01
1956 CYP1 B1 202435 s at 1.5771 E-02 5.64E-04 -3.55 -0.39 -7.54E-01
1957 ZDHHC7 218606 at 1.5771 E-02 5.65E-04 -3.55 -0.39 -4.41 E-01
1958 237153 at 1.5788E-02 5.65E-04 3.55 -0.39 1.64E-01
1959 HCLS1 202957 at 1.5790E-02 5.66E-04 -3.55 -0.39 -6.43E-01
1960 NAA35 220925 at 1.5806E-02 5.67E-04 -3.55 -0.39 -4.40E-01
1961 RICTOR 226312 at 1.5806E-02 5.67E-04 3.55 -0.39 3.43E-01 962 RUFY1 233380 s at 1.5806E-02 5.67E-04 -3.55 -0.39 -4.36E-01
1963 239489 at 1.5812E-02 5.68E-04 3.55 -0.39 2.81 E-01
1964 SYK 207540 s at 1.5812E-02 5.68E-04 -3.55 -0.39 -3.25E-01
1965 SERBP1 217725 x at 1.5812E-02 5.68E-04 -3.55 -0.39 -4.01 E-01
1966 RBM12///CP 212170_at 1.5812E-02 5.69E-04 3.55 -0.39 3.49E-01 NE1
1967 ASGR2 206130 s at 1.5818E-02 5.69E-04 -3.55 -0.39 -4.10E-01
1968 AKD1 1564002 a at 1.5824E-02 5.70E-04 3.54 -0.40 4.76E-01
1969 TMEM70 219448 at 1.5864E-02 5.71 E-04 3.54 -0.40 3.27E-01
1970 NUDT10 241596 at 1.5882E-02 5.72E-04 3.54 -0.40 1.59E-01
1971 MSI2 225237 s at 1.5914E-02 5.74E-04 3.54 -0.40 2.93E-01
No. Gene* Probe ID" Adj. p value P value t B Log FC
1972 SPIN3 1555883 s at 1.5914E-02 5.74E-04 3.54 -0.40 2.35E-01
1973 239131 at 1.5914E-02 5.75E-04 3.54 -0.40 2.96E-01
1974 TRPM7 223323 x at 1.5914E-02 5.75E-04 3.54 -0.40 2.52E-01
1975 RPS16P1/// 226130_at 1.5914E-02 5.75E-04 3.54 -0.40 3.07E-01 RPS16
1976 FKBP4 200894 s at 1.5914E-02 5.75E-04 -3.54 -0.40 -3.54E-01
1977 GGA2 214190 x at 1.5914E-02 5.76E-04 -3.54 -0.41 -2.93E-01
1978 LOC150166 229295 at 1.5914E-02 5.76E-04 -3.54 -0.41 -4.38E-01
1979 AMDHD1 229596 at 1.5914E-02 5.76E-04 3.54 -0.41 2.07E-01
1980 LOC374443 240572 s at 1.5914E-02 5.76E-04 3.54 -0.41 6.40E-01
1981 ARHGAP15 218870 at 1.5914E-02 5.77E-04 3.54 -0.41 4.43E-01
1982 KLF6 208961 s at 1.5930E-02 5.77E-04 -3.54 -0.41 -5.19E-01
1983 GNB1 200745 s at 1.5965E-02 5.79E-04 -3.54 -0.41 -5.96E-01
1984 SNRPD2 200826 at 1.5978E-02 5.80E-04 3.54 -0.41 4.81 E-01
1985 ITGB2 1555349 a at 1.5978E-02 5.81 E-04 -3.54 -0.41 -9.10E-01
1986 TMEM93 221255 s at 1.5978E-02 5.81 E-04 3.54 -0.41 3.20E-01
1987 1562046 at 1.5978E-02 5.81 E-04 3.54 -0.41 1.41 E-01
1988 QRSL1 241933_at 1.5978E-02 5.81 E-04 3.54 -0.41 3.53E-01
1989 C2orf34 1554875 at 1.5981E-02 5.81 E-04 3.54 -0.41 1.53E-01
1990 RET 205879_x_at 1.6011E-02 5.83E-04 3.54 -0.42 2.14E-01
1991 SEZ6L2 233337 s at 1.6011E-02 5.83E-04 -3.54 -0.42 -2.47E-01
1992 PPP1 R3B 222662 at 1.6011 E-02 5.84E-04 -3.54 -0.42 -3.97E-01
1993 COPA 214336 s at 1.6011 E-02 5.84E-04 -3.54 -0.42 -3.28E-01
1994 MFSD4 229254 at 1.6011 E-02 5.84E-04 3.54 -0.42 2.28E-01
1995 242680 at 1.6031 E-02 5.85E-04 -3.54 -0.42 -4.30E-01
1996 GANAB 214626 s at 1.6092E-02 5.88E-04 -3.54 -0.42 -3.27E-01
1997 PDE4DIP 212392 s at 1.6092E-02 5.88E-04 -3.54 -0.42 -1.79E-01
1998 237566 at 1.6092E-02 5.88E-04 3.54 -0.42 1.01 E-01
1999 CD96 1555120 at 1.6095E-02 5.88E-04 3.54 -0.42 6.43E-01
2000 CD40 35150 at 1.6125E-02 5.90E-04 -3.53 -0.43 -4.58E-01
2001 1558764 at 1.6125E-Q2 5.90E-04 3.53 -0.43 1.00E-01
2002 CENPM 218741 at 1.6125E-02 5.90E-04 3.53 -0.43 4.15E-01
2003 CD74 1567628 at 1.6133E-02 5.91 E-04 -3.53 -0.43 -1.08E+00
2004 1556982 at 1.6138E-02 5.92E-04 3.53 -0.43 2.09E-01
2005 LOC100129 235475_at 1.6152E-Q2 5.92E-04 3.53 -0.43 4.88E-01 720
2006 PDIA3 227033 at 1.6156E-02 5.93E-04 -3.53 -0.43 -4.08E-01
2007 EIF3A 200596 s at 1.6260E-02 5.97E-04 -3.53 -0.44 -3.41 E-01
2008 PIK3C2A 241905 at 1.6264E-02 5.97E-04 3.53 -0.44 3.18 E-01
2009 FST 204948 s at 1.6270E-02 5.98E-04 -3.53 -0.44 -5.39E-01
2010 EFCAB6 234853 s at 1.6270E-02 5.98E-04 3.53 -0.44 1.04E-01
2011 ADAM10 202604 x at 1.6303E-02 6.00E-04 -3.53 -0.44 -3.39E-01
2012 LOC339505 1557373 at 1.6314E-02 6.01 E-04 3.53 -0.44 1.44E-01
2013 CLASP2 1555469 a at 1.6314E-02 6.01 E-04 3.53 -0.44 1.64E-01
2014 208421_at 1.6314E-02 6.01 E-04 3.53 -0.44 1.42E-01
2015 237065 s at 1.6314E-02 6.02E-04 3.53 -0.44 2.87E-01
2016 POR 208928 at 1.6314E-02 6.02E-04 -3.53 -0.44 -4.36E-01
2017 DPYD 204646_at 1.6314E-02 6.02E-04 -3.53 -0.45 -4.23E-01
2018 C15orf40 1552310_at 1.6314E-02 6.02E-04 3.53 -0.45 5.42E-01
2019 LRRC27 1558484_s_at 1.6437E-02 6.07E-04 -3.53 -0.45 -2.35E-01
2020 ZNF319 228460 at 1.6437E-02 6.08E-04 -3.53 -0.45 -2.33E-01
2021 THY1 208851 s at 1.6437E-02 6.08E-04 -3.53 -0.45 -4.89E-01
2022 TTL 224896 s at 1.6437E-02 6.08E-04 -3.53 -0.45 -3.34E-01
2023 226885 at 1.6439E-02 6.08E-04 -3.53 -0.45 -3.63E-01
2024 TAPT1 238798 at 1.6439E-02 6.09E-04 3.53 -0.45 1.69E-01
2025 FTHL5 211628 x at 1.6448E-02 6.09E-04 -3.53 -0.46 -3.44E-01
2026 CXorf26 224177 s at 1.6450E-02 6.10E-04 -3.52 -0.46 -4.53E-01
2027 HYDIN 1554907 a at 1.6450E-02 6.10E-04 3.52 -0.46 1.65E-01
2028 RPL30 200062 s at 1.6459E-02 6.10E-04 3.52 -0.46 1.48E-01
2029 NRBP1 217765 at 1.6502E-02 6.12E-04 -3.52 -0.46 -3.80E-01
2030 228611 s at 1.6513E-02 6.13E-04 3.52 -0.46 3.18E-01
2031 PSMD3 201388 at 1.6513E-02 6.13E-04 -3.52 -0.46 -4.31 E-01
2032 240790 at 1.6532E-02 6.14E-04 3.52 -0.46 1.71 E-01
2033 239122 at 1.6550E-02 6.15E-04 3.52 -0.46 4.28E-01
2034 ERAP1 210385 s at 1.6558E-02 6.16E-04 -3.52 -0.47 -4.03E-01
2035 GIGYF1 228755 at 1.6558E-02 6.16E-04 3.52 -0.47 2.83E-01
2036 NOL10 218591 s at 1.6558E-02 6.17E-04 3.52 -0.47 1.31 E-01
2037 ARID1 B 1566989 at 1.6572E-02 6.17E-04 3.52 -0.47 3.38E-01
2038 HLA-G 211529 x at 1.6572E-02 6.18E-04 -3.52 -0.47 -4.38E-01
JO
No. Gene* Probe ID** Adj. p value P value t B Log FC
2039 PPM1 K 235061_at 1.6572E-02 6.18E-04 3.52 -0.47 4.52E-01
2040 MAP2K5 216765 at 1.6581 E-02 6.19E-04 3.52 -0.47 1.86E-01
2041 MAPK13 210058 at 1.6589E-02 6.19E-04 -3.52 -0.47 -3.46E-01
2042 235102 x at 1.6607E-02 6.20E-04 3.52 -0.47 1.21E+00
2043 TAGLN 1555724 s at 1.6610E-02 6.21 E-04 -3.52 -0.47 -8.08E-01
2044 AKIRIN2 223143 s at 1.6610E-02 6.22E-04 -3.52 -0.47 -1.70E-01
2045 SPATA24 238027 at 1.6610E-02 6.22E-04 3.52 -0.47 2.17E-01
2046 TMEM223 220934 s at 1.6610E-02 6.22E-04 3.52 -0.47 3.76E-01
2047 KLC1 212877 at 1.6610E-02 6.22E-04 -3.52 -0.47 -2.28E-01
2048 PALMD 218736_s_ at 1.6610E-02 6.23E-04 -3.52 -0.48 -5.12E-01
2049 1570014 at 1.6610E-02 6.23E-04 3.52 -0.48 1.44E-01
2050 GNB2 200852 x at 1.6610E-02 6.23E-04 -3.52 -0.48 -7.16E-01
2051 KIAA0101 202503 s at 1.6610E-02 6.23E-04 3.52 -0.48 6.78E-01
2052 ARPC1 B 201954 at 1.6619E-02 6.24E-04 -3.52 -0.48 -3.66E-01
2053 EBLN2 219906 at 1.6619E-02 6.24E-04 3.52 -0.48 3.05E-01
2054 SCARB1 1552256 a at 1.6619E-02 6.24E-04 -3.52 -0.48 -5.42E-01
2055 TIMP1 201666 at 1.6619E-02 6.25E-04 -3.52 -0.48 -8.76E-01
2056 TMBIM6 200804 at 1.6619E-02 6.25E-04 -3.52 -0.48 -4.35E-01
2057 BCAP31 200837 at 1.6619E-02 6.25E-04 -3.52 -0.48 -4.30E-01
2058 SNX20 229045 at 1.6619E-02 6.26E-04 -3.52 -0.48 -2.58E-01
2059 GAA 202812 at 1.6619E-02 6.26E-04 -3.52 -0.48 -4.96E-01
2060 NINJ1 203045 at 1.6628E-02 6.26E-04 -3.52 -0.48 -6.35E-01
2061 TBC1 D8 241017 at 1.6633E-02 6.27E-04 3.52 -0.48 6.56E-01
2062 PLXNB2 208890 s at 1.6637E-02 6.28E-04 -3.52 -0.48 -5.64E-01
2063 2381 13 at 1.6637E-02 6.28E-04 3.52 -0.48 1.25E-01
2064 233867 at 1.6638E-02 6.28E-04 3.52 -0.48 5.98E-01
2065 CALU 200756 x at 1.6643E-02 6.29E-04 -3.52 -0.48 -5.10E-01
2066 SCAMP2 218143 s at 1.6645E-02 6.29E-04 -3.52 -0.48 -4.44E-01
2067 RBM33 231834 at 1.6645E-02 6.29E-04 3.52 -0.48 1.60E-01
2068 TMEM68 227936 at 1.6645E-02 6.30E-04 3.52 -0.49 6.57E-01
2069 IFIT 2 201315 x at 1.6645E-02 6.30E-04 -3.52 -0.49 -5.08E-01
2070 PRKAB1 201835 s at 1.6661 E-02 6.31 E-04 -3.51 -0.49 -4.43E-01
2071 GLIPR2 225602 at 1.6661 E-02 6.31 E-04 -3.51 -0.49 -3.25E-01
2072 FBXW2 218941 at 1.6672E-02 6.32E-04 -3.51 -0.49 -3.49E-01
2073 ELL3 219517 at 1.6698E-02 6.33E-04 3.51 -0.49 7.54E-01
2074 ZNF708 239482 x at 1.6698E-02 6.33E-04 3.51 -0.49 4.36E-01
2075 244371 at 1.6747E-02 6.36E-04 3.51 -0.49 1.92E-01
2076 COL7A1 217312 s at 1.6792E-02 6.38E-04 -3.51 -0.50 -1.90E-01
2077 LYRM7 240344 x at 1.6793E-02 6.38E-04 3.51 -0.50 3.41 E-01
2078 REPS1 215201 at 1.6795E-02 6.38E-04 3.51 -0.50 2.21 E-01
2079 RAB31 217764 s at 1.6795E-02 6.39E-04 -3.51 -0.50 -5.26E-01
2080 POSTN 1555777 at 1.6795 E-02 6.39E-04 -3.51 -0.50 -2.95E-01
2081 C10orf10 209183 s at 1.6832E-02 6.41 E-04 -3.51 -0.50 -5.87E-01
2082 ALDOA 200966 x at 1.6841 E-02 6.41 E-04 -3.51 -0.50 -4.97E-01
2083 TMEM106C 201764 at 1.6843E-02 6.42E-04 3.51 -0.50 4.93E-01
2084 FCER1G 1554899 s at 1.6843E-02 6.42E-04 -3.51 -0.50 -1.04E+00
2085 MIB1 224722 at 1.6845E-02 6.42E-04 3.51 -0.50 3.27E-01
2086 ZNF146 1554433 a at 1.6859E-02 6.43E-04 -3.51 -0.50 -4.44E-01
2087 244187 at 1.6859E-02 6.44E-04 -3.51 -0.50 -1.97E-01
2088 SDK2 234073 at 1.6882E-02 6.45E-04 3.51 -0.51 1.62E-01
2089 ZFAND3 222493 s at 1.6882E-02 6.45E-04 -3.51 -0.51 -3.22E-01
2090 AG2 227099 s at 1.6882E-02 6.45E-04 -3.51 -0.51 -8.74E-01
2091 AK7 241326 at 1.6929E-02 6.48E-04 3.51 -0.51 2.04E-01
2092 LOC100129 221979_at 1.6929E-02 6.48E-04 3.51 -0.51 4.37E-01 250
2093 APOA1 204450 x at 1.6929E-02 6.48E-04 3.51 -0.51 1.49E-01
2094 TARBP1 202813 at 1.6940E-02 6.49E-04 3.51 -0.51 3.20E-01
2095 SHMT1 209980 s at 1.6955E-02 6.50E-04 -3.51 -0.51 -2.88E-01
2096 MY01 E 203072 at 1.6955E-02 6.50E-04 -3.51 -0.51 -3.42E-01
2097 ECM1 209365 s at 1.6955E-02 6.50E-04 -3.51 -0.51 -6.51 E-01
2098 HIST3H2A 221582 at 1.6969E-02 6.51 E-04 3.51 -0.52 6.33E-01
2099 VPS24 222436 s at 1.6969E-02 6.51 E-04 -3.51 -0.52 -4.33E-01
2100 SPARCL1 200795 at 1.6999E-02 6.53E-04 -3.50 -0.52 -4.79E-01
2101 BAX 208478 s at 1.6999E-02 6.53E-04 -3.50 -0.52 -4.62E-01
2102 FGFR10P2 223262 s at 1.701 OE-02 6.54E-04 3.50 -0.52 2.75E-01
2103 UBE2NL 217393 x at 1.7012E-02 6.54E-04 3.50 -0.52 1.57E-01
2104 1558275 at 1.7049E-02 6.56E-04 3.50 -0.52 2.45E-01
2105 OR2F2///OR 208525_s_at 1.7049E-02 6.57E-04 3.50 -0.52 1.26E-01 2F1
Wo. Gene* Probe ID** Adj. p value P value t B Log FC
2106 216431 at 1.7049E-02 6.57E-04 3.50 -0.52 1.67E-01
2107 PSMC2 201068 s at 1.7049E-02 6.57E-04 -3.50 -0.52 -2.71 E-01
2108 RPS26P57// 234885_at 1.7068E-02 6.58E-04 3.50 -0.52 2.03E-01 /ODZ1
2109 NLGN3 234751 s at 1.7103E-02 6.60E-04 3.50 -0.53 1.69E-01
2110 MGC21881 1555874 x at 1.7103E-02 6.60E-04 3.50 -0.53 3.10E-01
211 1 221725 at 1.7136E-02 6.62E-04 -3.50 -0.53 -4.89E-01
2112 SASH1 226022 at 1.7136E-02 6.62E-04 -3.50 -0.53 -6.82E-01
21 13 CAST 207467 x at 1.7139E-02 6.63E-04 -3.50 -0.53 -3.75E-01
2114 PSAP 200866 s at 1.7139E-02 6.63E-04 -3.50 -0.53 -7.82E-01
2115 EFTUD1 218973 at 1.7141 E-02 6.63E-04 -3.50 -0.53 -3.27E-01
2116 LILRB1 229937 x at 1.7141E-02 6.63E-04 -3.50 -0.53 -5.80E-01
2117 TRIM59 235476 at 1.7147E-02 6.64E-04 3.50 -0.53 3.77E-01
2118 CR1 208488 s at 1.7147E-02 6.65E-04 -3.50 -0.53 -2.89E-01
2119 DNTTIP1 234942 s at 1.7147E-02 6.65E-04 -3.50 -0.53 -5.99E-01
2120 S100A10 200872 at 1.7147E-02 6.65E-04 -3.50 -0.53 -4.66E-01
2121 FKBP10 219249 s at 1.7147E-02 6.65E-04 -3.50 -0.53 -2.99E-01
2122 241003 at 1.7153E-02 6.66E-04 3.50 -0.53 1.86E-01
2123 RAPGEF6 230078 at 1.7158E-02 6.66E-04 3.50 -0.54 4.30E-01
2124 RPL15 221475 s at 1.7162E-02 6.67E-04 3.50 -0.54 2.86E-01
2125 HTATSF1 202602 s at 1.7195E-02 6.68E-04 -3.50 -0.54 -4.30E-01
2126 UBR5 1555888 at 1.7213E-02 6.69E-04 3.50 -0.54 4.38E-01
2127 MY07A 208189 s at 1.7213E-02 6.70E-04 -3.50 -0.54 -5.08E-01
2128 241568 at 1.7225E-02 6.71 E-04 3.50 -0.54 1.79E-01
2129 MEM01 219065 s at 1.7225E-02 6.71 E-04 3.50 -0.54 2.92E-01
2130 EXOSC8 215136 s at 1.7231 E-02 6.71 E-04 3.50 -0.54 4.06E-01
2131 FXR1 201635 s at 1.7240E-02 6.72E-04 -3.50 -0.54 -5.05E-01
2132 KRCC1 222585 x at 1.7240E-02 6.72E-04 3.50 -0.54 4.91 E-01
2133 HSPA8 221891 x_at 1.7244E-02 6.73E-04 -3.50 -0.54 -2.65E-01
2134 HLA-C 214459 x at 1.7272E-02 6.74E-04 -3.50 -0.55 -3.82E-01
2135 PEX13 1558164 s at 1.7272E-02 6.74E-04 3 50 -0.55 2.57E-01
2136 LCP1 208885 at 1.7272E-02 6.75E-04 -3.50 -0.55 -6.66E-01
2137 RNF24 210706 s at 1.7277E-02 6.75E-04 -3.49 -0.55 -3.45E-01
2138 SEPN1 224659 at 1.7277E-02 6.76E-04 -3.49 -0.55 -5.61 E-01
2139 SGMS2 227038 at 1.7313E-02 6.77E-04 -3.49 -0.55 -5.04E-01
2140 GK 207387 s at 1.7316E-02 6.78E-04 -3.49 -0.55 -7.03E-01
2141 PDPN 204879 at 1.7323E-02 6.78E-04 -3.49 -0.55 -6.07E-01
2142 LOC100287 1554194_at 1.7347E-02 6.80E-04 3.49 -0.55 1.74E-01 037
2143 CMAS 218111 s at 1.7347E-02 6.80E-04 -3.49 -0.55 -2.63E-01
2144 DPAGT1 209509 s at 1.7348E-02 6.80E-04 -3.49 -0.55 -3.40E-01
2145 237345 at 1.7356E-02 6.81 E-04 3.49 -0.56 2.42E-01
2146 HYOU1 200825 s at 1.7356E-02 6.81 E-04 -3.49 -0.56 -5.25E-01
2147 C1orf46 216718 at 1.7365E-02 6.82E-04 3.49 -0.56 1.39E-01
2148 PSMD1 201199 s at 1.7373E-02 6.83E-04 -3.49 -0.56 -3.01 E-01
2149 TGFB1 203085 s at 1.7385E-02 6.83E-04 -3.49 -0.56 -8.77E-01
2150 236531 at 1.7385E-02 6.84E-04 3.49 -0.56 1.85E-01
2151 Sep-08 208999 at 1.7387E-02 6.84E-04 -3.49 -0.56 -5.29E-01
2152 PSEN1 203460 s at 1.7389E-02 6.85E-04 -3.49 -0.56 -2.91 E-01
2153 SFRS12IP1 1553581 s at 1.7389E-02 6.85E-04 3.49 -0.56 4.12E-01
2154 C5orf42 219381 at 1.7445E-02 6.87E-04 3.49 -0.56 1.58E-01
2155 CMIP 224991 at 1.7511 E-02 6.90E-04 -3.49 -0.57 -5.18E-01
2156 ROCK1 230239 at 1.7511 E-02 6.91 E-04 3.49 -0.57 2.20E-01
2157 GINS2 221521 s at 1.7513E-02 6.91 E-04 3.49 -0.57 6.39E-01
2158 239497 at 1.7571E-02 6.94E-04 3.49 -0.57 1.86E-01
2159 BRWD1 1553227 s at 1.7571 E-02 6.94E-04 3.49 -0.57 2.12E-01
2160 C14orf148 231566 at 1.7590E-02 6.95E-04 3.49 -0.57 1.45E-01
2161 ZNF33B 215022 x at 1.7590E-02 6.96E-04 3.49 -0.57 3.40E-01
2162 227796 at 1.7590E-02 6.96E-04 3.49 -0.57 3.36E-01
2163 TAF8 229412 at 1.7590E-02 6.96E-04 3.49 -0.57 2.74E-01
2164 240656 at 1.7590E-02 6.96E-04 3.49 -0.57 1.82E-01
2165 HSPA4 211015 s at 1.7601 E-02 6.97E-04 -3.49 -0.58 -6.46E-01
2166 1563577 at 1.7637E-02 6.99E-04 3.48 -0.58 2.44E-01
2167 ACTL9 243208 x at 1.7647E-02 7.00E-04 3.48 -0.58 1.45E-01
2168 EIF4H 206621 s at 1.7647E-02 7.00E-04 -3.48 -0.58 -6.33E-01
2169 JAK1 1562103 at 1.7647E-02 7.00E-04 3.48 -0.58 1.64E-01
2170 SERPINE1 202627 s at 1.7647E-02 7.01 E-04 -3.48 -0.58 -7.03E-01
2171 ACLY 210337 s at 1.7647E-02 7.01 E-04 -3.48 -0.58 -4.65E-01
2172 1558885 at 1.7647E-02 7.02E-04 3.48 -0.58 1.12E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
2173 UCKL1 232727 at 1.7647E-02 7.02E-04 3.48 -0.58 2.11E-01
2174 ATP6V0C 200954 at 1.7647E-02 7.02E-04 -3.48 -0.58 -6.12E-01
2175 ITPR2 202662 s at 1.7647E-02 7.02E-04 -3.48 -0.58 -4.24E-01
2176 242696 at 1.7647E-02 7.03E-04 3.48 -0.58 2.85E-01
2177 RHOJ 235489 at 1.7647E-02 7.03E-04 -3.48 -0.58 -4.68E-01
2178 1556728 at 1.7677E-02 7.04E-04 3.48 -0.58 2.55E-01
2179 1566110 at 1.7679E-02 7.05E-04 3.48 -0.59 2.17E-01
2180 SPATA1 221057 at 1.7687E-02 7.05E-04 3.48 -0.59 1.20E-01
2181 LG N 201212 at 1.7711 E-02 7.07E-04 -3.48 -0.59 -6.34E-01
2182 PECAM1 208983 s at 1.7732E-02 7.08E-04 -3.48 -0.59 -7.00E-01
2183 NAA25 227245_at 1.7734E-02 7.08E-04 -3.48 -0.59 -2.75E-01
2184 ITPRIPL2 1568619_s at 1.7738E-02 7.09E-04 -3.48 -0.59 -6.89E-01
2185 AP1S3 1555734 x at 1.7738E-02 7.09E-04 3.48 -0.59 1.59E-01
2186 CSTA 204971 at 1.7767E-02 7.10E-04 3.48 -0.59 7.24E-01
2187 C21orf129 1553918 at 1.7770E-02 7.11 E-04 3.48 -0.59 1.58E-01
2188 C6orf162 213312_at 1.7770E-02 7.11E-04 3.48 -0.59 5.32E-01
2189 LOC348761 240590 at 1.7770E-02 7.11 E-04 3.48 -0.59 1.59E-01
2190 WDR45 209216 at 1.7783E-02 7.12E-04 -3.48 -0.59 -3.25E-01
2191 TDH 212251 at 1.7823E-02 7.14E-04 -3.48 -0.60 -3.34E-01
2192 PRKG2 207505 at 1.7848E-02 7.16E-04 3.48 -0.60 1.72E-01
2193 NFIC 213298 at 1.7849E-02 7.16E-04 -3.48 -0.60 -4.44E-01
2194 SLC16A1 202234 s at 1.7849E-02 7.17E-04 -3.48 -0.60 -2.94E-01
2195 AKAP10 236007 at 1.7849E-02 7.17E-04 3.48 -0.60 5.63E-01
2196 SFRS18 226412 at 1.7855E-02 7.17E-04 3.48 -0.60 5.16E-01
2197 MS4A6A 219666 at 1.7876E-02 7.18E-04 -3.48 -0.60 -5.93E-01
2198 AK3L2///AK4 204348 s at 1.7882E-02 7.19E-04 -3.48 -0.60 -5.66E-01
2199 LOC100131 226006_at 1.7882E-02 7.19E-04 3.48 -0.60 4.57E-01 801
2200 1565788 at 1.7882E-02 7.20E-04 3.48 -0.60 1.03E-01
2201 C14orf2 202279 at 1.7882E-02 7.20E-04 3.48 -0.60 4.96E-01
2202 MIF4GD 231727 s at 1.7882E-02 7.20E-04 -3.48 -0.60 -5.12E-01
2203 TIGD1 1553099 at 1.7947E-02 7.23E-04 3.47 -0.61 4.57E-01
2204 PGLS 230699 at 1.7963E-02 7.24E-04 3.47 -0.61 1.99E-01
2205 PZL3 227747 at 1.7963E-02 7.25E-04 3.47 -0.61 2.99E-01
2206 227727 at 1.7963E-02 7.25E-04 -3.47 -0.61 -4.63E-01
2207 PELI3 244214 at 1.7991 E-02 7.26E-04 3.47 -0.61 1.64E-01
2208 FLJ36031 229521 at 1.8008E-02 7.27E-04 -3.47 -0.61 -4.03E-01
2209 HMGCL 202772 at 1.8013E-02 7.28E-04 -3.47 -0.61 -2.24E-01
2210 GLUD2 215794 x at 1.8020E-02 7.28E-04 -3.47 -0.61 -4.64E-01
2211 IFNAR1 225669 at 1.8024E-02 7.29E-04 -3.47 -0.62 -4.03E-01
2212 SFRP2 223121 s at 1.8024E-02 7.29E-04 -3.47 -0.62 -1.76E+00
2213 EHD1 209038 s at 1.8024E-02 7.30E-04 -3.47 -0.62 -4.08E-01
2214 FBX042 221812 at 1.8024E-02 7.30E-04 3.47 -0.62 1.95E-01
2215 C2orf81 228265 at 1.8024E-02 7.30E-04 3.47 -0 62 1.12E-01
2216 FAH 202862 at 1.8031 E-02 7.31 E-04 -3.47 -0.62 -3.51 E-01
2217 CNRIP1 226751 at 1.8032E-02 7.31 E-04 -3.47 -0.62 -5.98E-01
2218 GNA1 1 213944 x at 1.8032E-02 7.32E-04 -3.47 -0.62 -2.05E-01
2219 RIC8A 221647 s at 1.8043E-02 7.32E-04 -3.47 -0.62 -3.06E-01
2220 EEF2K 225545 at 1.8063E-02 7.33E-04 -3.47 -0.62 -3.53E-01
2221 POSTN 1555778 a at 1.8068E-02 7.34E-04 -3.47 -0.62 -1.67E+00
2222 LOC440288 239792 at 1.8068E-02 7.34E-04 3.47 -0.62 3.63E-01
2223 1556332 at 1.8082E-02 7.35E-04 -3.47 -0.62 -2.87E-01
2224 220902 at 1.81 14E-02 7.37E-04 3.47 -0.63 1.32E-01
2225 SNRPD1 202691 at 1.8174E-02 7.40E-04 3.47 -0.63 4.06E-01
2226 CYP1 B1 202437 s at 1.8186E-02 7.41 E-04 -3.47 -0.63 -8.24E-01
2227 NSFL1C 220248 x at 1.8186E-02 7.41 E-04 -3.47 -0.63 -3.87E-01
2228 NSFL1 C 232520 s at 1.8186E-02 7.42E-04 -3.47 -0.63 -3.48E-01
2229 RAB6C///RA 210406_s_at 1.8186E-02 7.42E-04 -3.47 -0.63 -3.11 E-01 B6A
2230 CEPT1 1561884 at 1.8186E-02 7.42E-04 3.47 -0.63 2.79E-01
2231 1562933 at 1.8 86E-02 7.42E-04 3.47 -0.63 1.44E-01
2232 244068 at 1.8199E-02 7.43E-04 3.47 -0.63 1.86E-01
2233 FAM168B 229946 at 1.8199E-02 7.43E-04 -3.47 -0.63 -1.73E-01
2234 SLC1A6 1554593 s at 1.8236E-02 7.45E-04 3.47 -0.63 1.07E-01
2235 TRIO 20901 1 at 1.8247E-02 7.46E-04 -3.47 -0.64 -2.72E-01
2236 RASGRP1 205590 at 1.8247E-02 7.46E-04 3.47 -0.64 4.11 E-01
2237 HERC4 233509 at 1.8252E-02 7.47E-04 3.46 -0.64 1.54E-01
2238 TAPBP 1555565 s at 1.8252E-02 7.47E-04 -3.46 -0.64 -3.09E-01
2239 PFDN5 210908 s at 1.8252E-02 7.47E-04 3.46 -0.64 4.42E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
2240 PANX1 204715 at 1.8267E-02 7.49E-04 -3.46 -0.64 -3.61 E-01
2241 215993 at 1.8267E-02 7.49E-04 3.46 -0.64 1.05E-01
2242 CDC5L 222179 at 1.8267E-02 7.49E-04 3.46 -0.64 1.15E-01
2243 239086 at 1.8267E-02 7.50E-04 3.46 -0.64 3.64E-01
2244 RPS4XP17// 216342_x_at 1.8267E-02 7.50E-04 3.46 -0.64 2.58E-01 /RPS4XP7///
RPS4XP13//
/RPS4X
2245 SLC5A9 232378 at 1.8270E-02 7.50E-04 3.46 -0.64 1.54E-01
2246 C10orf78 238794 at 1.8271 E-02 7.51 E-04 3.46 -0.64 6.04E-01
2247 SYNGR1 204287 at 1.8277E-02 7.52E-04 3.46 -0.64 1.92E-01
2248 1562557 at 1.8277E-02 7.52E-04 3.46 -0.64 2.35E-01
2249 ING3 231863 at 1.8277E-02 7.52E-04 3.46 -0.64 5.27E-01
2250 VIPR1 205019 s at 1.8277E-02 7.53E-04 3.46 -0.64 3.09E-01
2251 NR2F6 209262 s at 1.8277E-02 7.53 E-04 -3.46 -0.64 -3.67E-01
2252 C8orf59 226165 at 1.8277E-02 7.53E-04 3.46 -0.64 5.51 E-01
2253 KLF9 203543 s at 1.8277E-02 7.53E-04 -3.46 -0.64 -4.79E-01
2254 T2A 212185 x at 1.8282E-02 7.54E-04 -3.46 -0.65 -7.87E-01
2255 PIK3AP1 1554508 at 1.8282E-02 7.54E-04 -3.46 -0.65 -5.69E-01
2256 EIF2B4 215482 s at 1.8283E-02 7.54E-04 -3.46 -0.65 -2.23E-01
2257 CD59 228748 at 1.8301E-02 7.56E-04 -3.46 -0.65 -2.09E-01
2258 T C03 220240 s at 1.8301E-02 7.56 E-04 -3.46 -0.65 -3.44E-01
2259 NUS1 225070 at 1.8303E-02 7.56E-04 -3.46 -0.65 -5.02E-01
2260 ZNF436 226114 at 1.8321 E-02 7.57 E-04 -3.46 -0.65 -2.32E-01
2261 DKFZP547L 234912_at 1.8321 E-02 7.58E-04 3.46 -0.65 1.75E-01 112
2262 C10orf72 235471 at 1.8328E-02 7.58E-04 -3.46 -0.65 -1.87E-01
2263 T C03 230317_x_at 1.8361 E-02 7.60E-04 3.46 -0.65 1.48E-01
2264 SLC38A7 218727 at 1.8379E-02 7.61 E-04 -3.46 -0.65 -4.17E-01
2265 1559316 at 1.8379E-02 7.61 E-04 3.46 -0.65 1.51 E-01
2266 PARVB 204629 at 1.8379E-02 7.62E-04 -3.46 -0.65 -4.97E-01
2267 CAPZB 37012 at 1.8379E-02 7.62E-04 -3.46 -0.65 -4.32E-01
2268 LMF1 1569048 s at 1.8394E-02 7.64E-04 3.46 -0.66 1.87E-01
2269 MICAL3 229474_at 1.8394E-02 7.64E-04 3.46 -0.66 2.06E-01
2270 HSD17B12 1554122 a at 1.8394E-02 7.64E-04 3.46 -0.66 2.95E-01
2271 SURF4 222977 at 1.8394E-02 7.64E-04 -3.46 -0.66 -4.66E-01
2272 1565701 at 1.8394E-02 7.64E-04 3.46 -0.66 2.09E-01
2273 KBTBD2 223585 x at 1.8394E-02 7.65 E-04 -3.46 -0.66 -4.13E-01
2274 EPHA7 238533 at 1.8426E-02 7.66E-04 3.46 -0.66 1.22E-01
2275 HLA-G 210514 x at 1.8429E-02 7.67E-04 -3.46 -0.66 -5.20E-01
2276 ADA 3A 216276 s at 1.8436E-02 7.67E-04 3.46 -0.66 1.30E-01
2277 PWRN1 1562873 at 1.8440E-02 7.68E-04 3.46 -0.66 1.60E-01
2278 AK3L2///AK4 225342 at 1.8440E-02 7.68E-04 -3.46 -0.66 -6.92E-01
2279 TMEM189- 201001_s_at 1.8443E-02 7.69E-04 3.46 -0.66 2.66E-01
UBE2V1///U
BE2V1
2280 DEK 200934 at 1.8460E-02 7.70E-04 -3.46 -0.66 -2.68E-01
2281 237800 at 1.8461 E-02 7.70E-04 3.46 -0.66 1.32E-01
2282 PLEKHB2 201410 at 1.8462E-02 7.71 E-04 -3.46 -0.66 -3.32E-01
2283 CCDC48 233259 at 1.8468E-02 7.71 E-04 3.46 -0.67 1.22E-01
2284 CSDE1 202646 s at 1.8468E-02 7.72E-04 -3.45 -0.67 -2.81 E-01
2285 SRSF11 213742 at 1.8468E-02 7.73E-04 3.45 -0.67 4.29E-01
2286 ACTR1A 200721 s at 1.8468E-02 7.73E-04 -3.45 -0.67 -4.56E-01
2287 230415 at 1.8468E-02 7.73E-04 3.45 -0.67 3.67E-01
2288 COL15A1 203477 at 1.8468E-02 7.73E-04 -3.45 -0.67 -1.10E+00
2289 E P3 203729 at 1.8468E-02 7.73 E-04 -3.45 -0.67 -5.35E-01
2290 BPY2 208331 at 1.8468E-02 7.74E-04 3.45 -0.67 1.27E-01
2291 AGED1 209014 at 1.8468E-02 7.74E-04 -3.45 -0.67 -5.63E-01
2292 ALT1 210017 at 1.8468E-02 7.74E-04 3.45 -0.67 4.14E-01
2293 233376 at 1.8482E-02 7.75E-04 3.45 -0.67 1.56E-01
2294 NKX6-2 235832 at 1.8482E-02 7.75E-04 3.45 -0.67 1.68E-01
2295 TUBB3 213476 x at 1.8508E-02 7.77 E-04 -3.45 -0.67 -4.97E-01
2296 ASCC3 212815 at 1.8513E-02 7.78 E-04 -3.45 -0.67 -3.20E-01
2297 TBC1 D10B 220947 s at 1.8513E-02 7.78E-04 -3.45 -0.67 -3.09E-01
2298 NKX2-2 206915 at 1.8528E-02 7.79E-04 3.45 -0.67 1.20E-01
2299 MICA///HLA- 209140_x_at 1.8540E-02 7.80E-04 -3.45 -0.68 -3.92E-01 B
2300 XPNPEP1 208453 s at 1.8551 E-02 7.81 E-04 -3.45 -0.68 -5.62E-01
2301 FLVCR2 222866 s at 1.8551 E-02 7.81 E-04 -3.45 -0.68 -5.12E-01
2302 243491 at 1.8551 E-02 7.81 E-04 3.45 -0.68 1.93E-01
No. Gene* Probe ID** Adj. p value P value ί B Log FC
2303 WVCE 242957 at 1.8595E-02 7.83E-04 3.45 -0.68 2.56E-01
2304 ZNF74 205881 at 1.8600E-02 7.84E-04 -3.45 -0.68 -1.72E-01
2305 C4orf39 1553711 a at 1.8600E-02 7.8 E-04 3.45 -0.68 1.40E-01
2306 CCT8L2 220508 at 1.8610E-02 7.85E-04 3.45 -0.68 1.85E-01
2307 CISH 223377 x at 1.8610E-02 7.85E-04 -3.45 -0.68 -5.21 E-01
2308 BCL2L10 221320 at 1.8610E-02 7.86E-04 3.45 -0.68 1.87E-01
2309 GADD45B 209304 x at 1.8610E-02 7.86E-04 -3.45 -0.68 -3.96E-01
2310 APK13 210059 s at 1.8614E-02 7.87E-04 -3.45 -0.68 -2.45E-01
2311 1563706 at 1.8614E-02 7.87E-04 3.45 -0.68 1.55E-01
2312 238531 x at 1.8614E-02 7.88E-04 -3.45 -0.68 -4.93E-01
2313 SRPX2 205499 at 1.8614E-02 7.88E-04 -3.45 -0.69 -5.64E-01
2314 CASD1 231244 at 1.8614E-02 7.88E-04 3.45 -0.69 1.59 E-01
2315 MPND 233651 s at 1.8614E-02 7.88E-04 -3.45 -0.69 -5.46E-01
2316 TUBGCP4 21 1337 s at 1.8614E-02 7.88E-04 -3.45 -0.69 -3.02E-01
2317 PRKAG2 222582 at 1.8659E-02 7.91 E-04 3.45 -0.69 4.18E-01
2318 CYP1B1 202436 s at 1.8669E-02 7.91 E-04 -3.45 -0.69 -7.60E-01
2319 239081 at 1.8670E-02 7.92E-04 3.45 -0.69 4.55E-01
2320 NCAPH2 209718 at 1.8670E-02 7.92E-04 3.45 -0.69 2.37E-01
2321 SLC41A2 235299 at 1.8670E-02 7.93E-04 -3.45 -0.69 -5.49E-01
2322 YIF1A 202418 at 1.8670E-02 7.93E-04 -3.45 -0.69 -4.44E-01
2323 SNX9 223027 at 1.8670E-02 7.94E-04 -3.45 -0.69 -4.90E-01
2324 GUSBP3///S 215043_s_at 1.8670E-02 7.94E-04 -3.45 -0.69 -4.93E-01 MA5///SMA4
2325 GLUL 217202 s at 1.8670E-02 7.94E-04 -3.45 -0.69 -8.18E-01
2326 C21 orf67 1552528 at 1.8695E-02 7.95E-04 3.45 -0.69 1.45E-01
2327 ITGB3BP 205176 s at 1.8709E-02 7.97E-04 3.45 -0.69 7.26E-01
2328 UBE2D4 65521 at 1.8709E-02 7.97E-04 3.45 -0.69 2.14E-01
2329 RPL9 200032_s_at 1.8709E-02 7.97E-04 3.45 -0.69 2.24E-01
2330 ZNF430 206829 x at 1.8720E-02 7.98E-04 3.45 -0.70 3.78E-01
2331 HK3 205936 s at 1.8783E-02 8.01 E-04 -3.44 -0.70 -6.39E-01
2332 RPS10 200095 x at 1.8810E-02 8.02 E-04 3.44 -0.70 1.70E-01
2333 1557118 a at 1.8831 E-02 8.04E-04 3.44 -0.70 2.85E-01
2334 DPH5 222360 at 1.8866E-02 8.05E-04 3.44 -0.70 3.42E-01
2335 RAB2A 208734 x at 1.8866E-02 8.06E-04 -3.44 -0.70 -3.61 E-01
2336 RAB7B 1553982 a at 1.8870E-02 8.06E-04 -3.44 -0.71 -2.18E-01
2337 A AP8L 240554 at 1.8889E-02 8.08E-04 3.44 -0.71 2.50E-01
2338 MAZ 229807 s at 1.8889E-02 8.08E-04 3.44 -0.71 2.46E-01
2339 CD74 209619 at 1.8909E-02 8.09E-04 -3.44 -0.71 -5.86E-01
2340 TMEM131 212507 at 1.8945E-02 8.11 E-04 -3.44 -0.71 -4.93E-01
2341 SS18L2 218283 at 1.8945E-02 8.11 E-04 3.44 -0.71 5.36E-01
2342 CCDC23 226723 at 1.8994E-02 8.14E-04 3.44 -0.71 5.83E-01
2343 215667 x at 1.9035E-02 8.16E-04 3.44 -0.72 2.97E-01
2344 IQGAP1 210840 s at 1.9037E-02 8.16E-04 -3.44 -0.72 -3.01 E-01
2345 1562826 at 1.9042E-02 8.17E-04 3.44 -0.72 1.76E-01
2346 CUL4A 201423 s at 1.9071 E-02 8.18E-04 -3.44 -0.72 -2.70E-01
2347 NFE2L2 1567013 at 1.9098E-02 8.20E-04 -3.44 -0.72 -3.06E-01
2348 IVD 216958 s at 1.9126E-02 8.21 E-04 -3.44 -0.72 -3.31 E-01
2349 LMLN 244881 at 1.9129E-02 8.22E-04 -3.44 -0.72 -3.69E-01
2350 BAG3 217911 s at 1.9141 E-02 8.23E-04 -3.44 -0.72 -4.74E-01
2351 240892 at 1.9141 E-02 8.23E-04 3.44 -0.72 1.99E-01
2352 FAM1 10B 221959 at 1.9166E-02 8.25E-04 -3.44 -0.73 -2.01 E-01
2353 PELI1 218319 at 1.9166E-02 8.25E-04 3.44 -0.73 2.90E-01
2354 ZNF77 229000 at 1.9220E-02 8.28E-04 3.43 -0.73 3.45E-01
2355 ARF3 200734 s at 1.9220E-02 8.28E-04 -3.43 -0.73 -5.44E-01
2356 1568802 at 1.9220E-02 8.29E-04 3.43 -0.73 1.22E-01
2357 ACP2 202767 at 1.9220E-02 8.29E-04 -3.43 -0.73 -5.20E-01
2358 OLFML3 218162 at 1.9220E-02 8.29E-04 -3.43 -0.73 -1.02E+00
2359 TOMM20 212773 s at 1.9227E-02 8.30E-04 3.43 -0.73 5.79E-01
2360 KRTAP1-3 234880 x at 1.9268E-02 8.32E-04 3.43 -0.73 3.04E-01
2361 DAK 218688 at 1.9303E-02 8.34E-04 -3.43 -0.73 -2.75E-01
2362 DLGAP4 202572 s at 1.9308E-02 8.34E-04 -3.43 -0.74 -2.67E-01
2363 TIPRL 1553677 a at 1.9308E-02 8.34E-04 3.43 -0.74 3.41 E-01
2364 G0S2 213524 s at 1.9337E-02 8.36E-04 -3.43 -0.74 -6.12E-01
2365 LILRB3 211 135_x_at 1.9351 E-02 8.37 E-04 -3.43 -0.74 -4.90E-01
2366 AQP1 209047 at 1.9354E-02 8.38E-04 -3.43 -0.74 -8.73E-01
2367 ZNF673 206583 at 1.9361 E-02 8.38E-04 3.43 -0.74 3.14E-01
2368 TIPRL 214773 x at 1.9361 E-02 8.39E-04 3.43 -0.74 3.30E-01
2369 GPR174 224285 at 1.9361 E-02 8.39E-04 3.43 -0.74 2.91 E-01
2370 236143 at 1.9382E-02 8.40E-04 3.43 -0.74 1.87E-01
No. Gene* Probe ID** Adj. p value P value f 8 Log FC
2371 237201 at 1.9382E-02 8.41 E-04 3.43 -0.74 4.08E-01
2372 235423 at 1.9393E-02 8.41 E-04 3.43 -0.74 3.20E-01
2373 WT1 206067 s at 1.9402E-02 8.42E-04 -3.43 -0.74 -5.29E-01
2374 WDR13 222138 s at 1.9406E-02 8.43E-04 -3.43 -0.74 -3.44E-01
2375 CMTM6 217947 at 1.9413E-02 8.43E-04 -3.43 -0.74 -3.10E-01
2376 ELM02 221528 s at 1.9435E-02 8.45E-04 -3.43 -0.75 -4.48E-01
2377 235821 at 1.9448E-02 8.46E-04 -3.43 -0.75 -5.68E-01
2378 ALDOA 214687 x at 1.9448E-02 8.46E-04 -3.43 -0.75 -4.70E-01
2379 COL4A2 21 1964 at 1.9448E-02 8.47E-04 -3.43 -0.75 -9.34E-01
2380 TKT 208699 x at 1.9448E-02 8.47E-04 -3.43 -0.75 -7.00E-01
2381 SLC35E1 229410 at 1.9470E-02 8.48E-04 -3.43 -0.75 -2.85E-01
2382 HDGF 216484 x at 1.9479E-02 8.49E-04 -3.43 -0.75 -2.85E-01
2383 242731 x at 1.9480E-02 8.49E-04 3.43 -0.75 1.42E-01
2384 240969 at 1.9495E-02 8.50E-04 3.43 -0.75 1.39E-01
2385 234239 at 1.9495E-02 8.51 E-04 3.43 -0.75 1.51E-01
2386 GRN 216041 x at 1.9495E-02 8.51 E-04 -3.43 -0.75 -7.33E-01
2387 ALKBH5 228034 x at 1.9495E-02 8.51 E-04 3.43 -0.75 1.79E-01
2388 HEG1 212822 at 1.9567E-02 8.55E-04 -3.42 -0.76 -4.36E-01
2389 BACE2 217867 x at 1.9567E-02 8.55E-04 -3.42 -0.76 -5.72E-01
2390 GTF3A 201338_x at 1.9587E-02 8.56E-04 3.42 -0.76 3.31 E-01
2391 SIGLEC7 207224_s_at 1.9618E-02 8.58E-04 -3.42 -0.76 -5.12E-01
2392 GPR172A 222155_s_at 1.9671 E-02 8.61 E-04 -3.42 -0.76 -4.76E-01
2393 SRPR 200918 s at 1.9671 E-02 8.61 E-04 -3.42 -0.76 -5.61 E-01
2394 ATP13A3 212297 at 1.9671 E-02 8.61 E-04 -3.42 -0.76 -2.79E-01
2395 MARCKS 213002_at 1.9690E-02 8.62E-04 -3.42 -0.76 -3.96E-01
2396 LYZL4 231306 at 1.9701 E-02 8.63E-04 3.42 -0.77 1.82E-01
2397 HLA-DPB2 239975 at 1.9701 E-02 8.64E-04 3.42 -0.77 3.75E-01
2398 238129 s at 1.9708E-02 8.64E-04 -3.42 -0.77 -3.07E-01
2399 TM9SF1 209149 s at 1.9712E-02 8.65E-04 -3.42 -0.77 -4.20E-01
2400 COL1A2 202403 s at 1.9749E-02 8.67E-04 -3.42 -0.77 -1.06E+00
2401 C21 orf49 1557782 s at 1.9758E-02 8.68E-04 3.42 -0.77 1.41 E-01
2402 TMC5 240304 s at 1.9758E-02 8.68E-04 3.42 -0.77 1.43E-01
2403 LOC645513 1561759 at 1.9787E-02 8.70E-04 3.42 -0.77 1.49E-01
2404 WARS2 218766 s at 1.9798E-02 8.71 E-04 3.42 -0.77 4.14E-01
2405 PGBD4 243815 at 1.9798E-02 8.71 E-04 3.42 -0.77 3.64E-01
2406 233680 at 1.9821 E-02 8.72E-04 3.42 -0.77 1.35E-01
2407 CLTA 204050 s at 1.9850E-02 8.74E-04 -3.42 -0.78 -2.86E-01
2408 UBE2J1 217823 s at 1.9864E-02 8.75E-04 -3.42 -0.78 -3.59E-01
2409 ASPH 210896 s at 1.9864E-02 8.75E-04 -3.42 -0.78 -4.94E-01
2410 FLJ 10038 236164 at 1.9933E-02 8.79E-04 3.42 -0.78 2.18E-01
2411 CHIC1 1557786 s at 1.9964E-02 8.80E-04 3.42 -0.78 1.62E-01
2412 LAP3 217933 s at 2.0002E-02 8.82E-04 -3.42 -0.79 -4.08E-01
2413 FBX09 238472 at 2.0016E-02 8.83E-04 3.41 -0.79 2.52E-01
2414 ITGAM 205786 s at 2.0018E-02 8.84E-04 -3.41 -0.79 -6.24E-01
2415 TAX1 BP3 209154 at 2.0020E-02 8.84E-04 -3.41 -0.79 -5.04E-01
2416 EIF3J 208985 s at 2.0043E-02 8.86E-04 -3.41 -0.79 -2.35E-01
2417 LEPREL2 204854 at 2.0043E-02 8.86E-04 -3.41 -0.79 -2.32E-01
2418 RGS10 204316 at 2.0044E-02 8.87E-04 3.41 -0.79 4.06E-01
2419 SASH1 213236 at 2.0044E-02 8.87E-04 -3.41 -0.79 -6.76E-01
2420 C5AR1 220088 at 2.0044E-02 8.88E-04 -3.41 -0.79 -5.69E-01
2421 EHBP1 L1 91703 at 2.0044E-02 8.88E-04 -3.41 -0.79 -5.29E-01
2422 EEF1A1 213614 x at 2.0044E-02 8.88E-04 -3.41 -0.79 -1.12E-01
2423 ATP5L 207573 x at 2.0052E-02 8.89E-04 3.41 -0.79 3.92E-01
2424 FLJ36848 231698 at 2.0052E-02 8.90E-04 -3.41 -0.79 -4.21 E-01
2425 FZD1 204451 at 2.0052E-02 8.90E-04 -3.41 -0.79 -6.09E-01
2426 PPM1 L 239855 at 2.0052E-02 8.90E-04 3.41 -0.79 1.74E-01
2427 RRP7B///RR 202938_x_at 2.0130E-02 8.94E-04 -3.41 -0.80 -2.07E-01 P7A
2428 PDE4DIP 214130 s at 2.0136E-02 8.94E-04 -3.41 -0.80 -2.72E-01
2429 RNASE1 201785 at 2.0136E-02 8.95E-04 -3.41 -0.80 -1.01 E+00
2430 C12orf45 226349 at 2.0159E-02 8.96E-04 3.41 -0.80 5.66E-01
2431 WDR1 210935 s at 2.0161 E-02 8.97E-04 -3.41 -0.80 -7.63E-01
2432 HCP5 206082 at 2.0161 E-02 8.97E-04 3.41 -0.80 3.57E-01
2433 IL13RA1 210904 s at 2.0188E-02 8.99E-04 -3.41 -0.80 -7.95E-01
2434 LOC728216/ 1553592_x_at 2.0188E-02 9.00E-04 -3.41 -0.80 -1.08E-01 //LOC64416
5
2435 HIST1 H2AM 214481 at 2.0188E-02 9.00E-04 3.41 -0.80 2.75E-01
2436 MGST1 231736 x at 2.0188E-02 9.00E-04 -3.41 -0.80 -9.27E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
2437 PHF6 224442 at 2.0188E-02 9.01 E-04 3.41 -0.80 1.70E-01
2438 241219 at 2.0188E-02 9.01 E-04 3.41 -0.80 1.60E-01
2439 ZNF259P1/// 217185_s_at 2.0188E-02 9.02E-04 -3.41 -0.80 -4.15E-01 ZNF259
2440 CUX1 214743 at 2.0188E-02 9.02E-04 -3.41 -0.80 -4.91 E-01
2441 SPPL2A 226353 at 2.0188E-02 9.02E-04 -3.41 -0.80 -3.56E-01
2442 AN06 224906 at 2.0188E-02 9.02E-04 -3.41 -0.80 -2.89E-01
2443 RPL47 223480 s at 2.0188E-02 9.02E-04 3.41 -0.81 4.02E-01
2444 PHF20L1 227523 s at 2.0188E-02 9.02E-04 -3.41 -0.81 -3.80E-01
2445 SPATA3 240340 at 2.0192E-02 9.03E-04 -3.41 -0.81 -1.49E-01
2446 PLAU 211668 s at 2.0192E-02 9.03 E-04 -3.41 -0.81 -6.02E-01
2447 SOD2 215223 s at 2.0196E-02 9.04 E-04 -3.41 -0.81 -7.47E-01
2448 C16orf57 1554016 a at 2.0196E-02 9.04E-04 -3.41 -0.81 -4.24E-01
2449 SIRT2 220605 s at 2.0217E-02 9.06E-04 -3.41 -0.81 -2.11 E-01
2450 226832 at 2.0226E-02 9.06E-04 -3.41 -0.81 -4.89E-01
2451 215376 at 2.0234E-02 9.07E-04 3.41 -0.81 2.37E-01
2452 ZNF284 239462 at 2.0234E-02 9.08E-04 3.41 -0.81 2.19E-01
2453 LOC728769 238039 at 2.0234E-02 9.08E-04 3.41 -0.81 4.95E-01
2454 LEPROT 202378 s at 2.0260E-02 9.09E-04 -3.41 -0.81 -5.20E-01
2455 ABCC9 1557374 at 2.0271 E-02 9.10E-04 3.41 -0.81 1.59E-01
2456 1556613 s at 2.0271 E-02 9.11 E-04 3.41 -0.81 3.37E-01
2457 VRK1 203856 at 2.0271 E-02 9.11 E-04 3.41 -0.81 4.09E-01
2458 TFB2 1566930_at 2.0277E-02 9.12E-04 3.41 -0.81 8.57E-02
2459 LRRC20 218550 s at 2.0347E-02 9.16 E-04 -3.40 -0.82 -2.12E-01
2460 NKD1 1553115_at 2.0347E-02 9.17E-04 3.40 -0.82 1.96E-01
2461 C9orf163 1553642 at 2.0347E-02 9.17E-04 3.40 -0.82 1.99E-01
2462 EFNB1 202711 at 2.0347E-02 9.17E-04 -3.40 -0.82 -1.95E-01
2463 UQCRB 209065 at 2.0347E-02 9.17E-04 3.40 -0.82 5.61 E-01
2464 HSPA8 208687 x at 2.0353E-02 9.17E-04 -3.40 -0.82 -5.19E-01
2465 ETF1 201574 at 2.0368E-02 9.18 E-04 -3.40 -0.82 -3.32E-01
2466 GAS2 205848 at 2.0379E-02 9.19E-04 3.40 -0.82 2.65E-01
2467 CTSB 213275 x at 2.0386E-02 9.20E-04 -3.40 -0.82 -5.93E-01
2468 1554963 at 2.0386E-02 9.20E-04 3.40 -0.82 1.25E-01
2469 CLTA 200960 x at 2.0386E-02 9.21 E-04 -3.40 -0.82 -2.08E-01
2470 HADHA 208631 s at 2.0412E-02 9.22E-04 -3.40 -0.82 -5.08E-01
2471 230446 at 2.0445E-02 9.24E-04 3.40 -0.83 5.00E-01
2472 NSA2 201922 at 2.0445E-02 9.24E-04 3.40 -0.83 3.81 E-01
2473 IGFBP4 201508 at 2.0459E-02 9.25E-04 -3.40 -0.83 -8.24E-01
2474 TRI 26 242812 at 2.0502E-02 9.28E-04 3.40 -0.83 2.51 E-01
2475 1569487 at 2.0518E-02 9.29E-04 3.40 -0.83 2.07E-01
2476 PAM 214620 x at 2.0518E-02 9.29E-04 -3.40 -0.83 -2.62E-01
2477 1562965 at 2.0518E-02 9.30E-04 3.40 -0.83 1.52E-01
2478 GNB1 200744 s at 2.0528E-02 9.30E-04 -3.40 -0.83 -5.31 E-01
2479 ZNF492 215532 x at 2.0544E-02 9.31 E-04 3.40 -0.83 1.67E-01
2480 223930 at 2.0545E-02 9.32E-04 3.40 -0.83 2.13E-01
2481 FA 84B 228870 at 2.0558E-02 9.33E-04 3.40 -0.84 2.58E-01
2482 ARHGAP1 202117 at 2.0558E-02 9.34E-04 -3.40 -0.84 -5.21 E-01
2483 SI2 225240 s at 2.0558E-02 9.34E-04 3.40 -0.84 5.18E-01
2484 226377 at 2.0558E-02 9.34E-04 -3.40 -0.84 -6.05E-01
2485 DCTN2 200932 s at 2.0558E-02 9.34 E-04 -3.40 -0.84 -2.24E-01
2486 B4GALT4 210540 s at 2.0561 E-02 9.35E-04 -3.40 -0.84 -2.90E-01
2487 IVD 203682 s at 2.0623E-02 9.38E-04 -3.40 -0.84 -2.29E-01
2488 OS9 215399 s at 2.0623E-02 9.38E-04 -3.40 -0.84 -5.49E-01
2489 236829 at 2.0632E-02 9.39E-04 3.40 -0.84 2.44 E-01
2490 240226 at 2.0632E-02 9.40E-04 3.40 -0.84 1.31 E-01
2491 C21orf58 1559439 s at 2.0651 E-02 9.41 E-04 3.40 -0.84 1.34E-01
2492 ZNF780B 243294 at 2.0661 E-02 9.42E-04 3.40 -0.84 1.74E-01
2493 CFLAR 211317 s at 2.0671 E-02 9.43 E-04 -3.40 -0.84 -6.59E-01
2494 241823 at 2.0706E-02 9.45E-04 3.39 -0.85 2.31 E-01
2495 PPFIA1 202065 s at 2.0736E-02 9.46E-04 -3.39 -0.85 -3.23E-01
2496 TPM4 212481 s at 2.0757E-02 9.48E-04 -3.39 -0.85 -3.73E-01
2497 NELL2 203413 at 2.0811 E-02 9.50E-04 3.39 -0.85 7.15E-01
2498 TRADD 213443 at 2.0814E-02 9.51 E-04 3.39 -0.85 1.22E-01
2499 SEL1 L 202064 s at 2.0846E-02 9.53E-04 -3.39 -0.85 -3.65E-01
2500 CO D6 225312 at 2.0846E-02 9.53E-04 3.39 -0.85 4.78E-01
2501 ARVELD1 223095 at 2.0878E-02 9.55E-04 -3.39 -0.86 -4.60E-01
2502 PPP6R2 1570210 x at 2.0892E-02 9.56E-04 3.39 -0.86 3.66E-01
2503 CDC14A 210440 s at 2.0892E-02 9.56E-04 3.39 -0.86 1.68E-01
2504 L NA 212086 x at 2.0899E-02 9.57E-04 -3.39 -0.86 -3.52E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
2505 RGS5 209070 s at 2.0901 E-02 9.58E-04 -3.39 -0.86 -8.02E-01
2506 AZI1 214742 at 2.0931 E-02 9.59E-04 3.39 -0.86 2.90E-01
2507 SLC22A14 207408 at 2.0937E-02 9.60E-04 3.39 -0.86 1.96E-01
2508 BIRC5 210334 x at 2.0952E-02 9.61 E-04 3.39 -0.86 3.55E-01
2509 TSPAN3 200972 at 2.0969E-02 9.62E-04 -3.39 -0.86 -3.82E-01
2510 238156 at 2.0978E-02 9.63E-04 3.39 -0.86 L 5.34E-01
2511 TMEM205 225003 at 2.1039E-02 9.66E-04 -3.39 -0.87 -4.65E-01
2512 CYGB 226632 at 2.1039E-02 9.67E-04 -3.39 -0.87 -4.60E-01
2513 FLJ40606 1560162 at 2.1039E-02 9.67E-04 3.39 -0.87 1.93E-01
2514 1559867 at 2.1051E-02 9.68E-04 3.39 -0.87 2.03E-01
2515 QKI 236154 at 2.1051 E-02 9.68E-04 -3.39 -0.87 -2.26E-01
2516 SLC16A6 207038 at 2.1070E-02 9.70E-04 3.39 -0.87 2.03E-01
2517 GLUL 215001 s at 2.1082E-02 9.71 E-04 -3.39 -0.87 -4.30E-01
2518 235378 at 2.1082E-02 9.71 E-04 -3.39 -0.87 -1.47E-01
2519 FKBP15 212663 at 2.1086E-02 9.72E-04 -3.39 -0.87 -3.51 E-01
2520 TXNDC5 221253 s at 2.1086E-02 9.72E-04 -3.39 -0.87 -6.36E-01
2521 LRRC34 236918 s at 2.1091 E-02 9.72E-04 3.39 -0.87 1.98E-01
2522 1560144 at 2.1100E-02 9.74E-04 3.39 -0.87 2.57E-01
2523 239175_at 2.1100E-02 9.74E-04 3.39 -0.87 4.75E-01
2524 SH3PXD2B 231823 s at 2.1110E-02 9.75E-04 -3.39 -0.87 -6.58E-01
2525 B4GALT5 221484 at 2.1175E-02 9.78E-04 -3.38 -0.88 -5.48E-01
2526 RB 11 232549 at 2.1203E-02 9.80E-04 3.38 -0.88 2.25E-01
2527 ZNF230 1557322 at 2.1203E-02 9.80E-04 3.38 -0.88 2.15E-01
2528 RPRD1A 228566 at 2.1203 E-02 9.80E-04 3.38 -0.88 3.21 E-01
2529 NLGN4X 1554689 a at 2.1205E-02 9.81 E-04 -3.38 -0.88 -1.51 E-01
2530 TNFRSF10B 209294 x at 2.1247E-02 9.83E-04 -3.38 -0.88 -2.39E-01
2531 FCER1G 204232 at 2.1287E-02 9.85E-04 -3.38 -0.88 -8.71 E-01
2532 DDX3Y 205001 s at 2.1288E-02 9.86E-04 -3.38 -0.88 -8.96E-01
2533 TCTN3 212121_at 2.1292E-02 9.87E-04 -3.38 -0.88 -4.70E-01
2534 LINS1 220121 at 2.1292E-02 9.87E-04 3.38 -0.88 3.49E-01
2535 ZNF547///T 219351_at 2.1306E-02 9.88E-04 3.38 -0.89 4.43E-01
RAPPC2P1/
//TRAPPC2
2536 HDDC2 203259 s at 2.1307E-02 9.89E-04 3.38 -0.89 3.84E-01
2537 AKAP7 205771 s at 2.1307E-02 9.89E-04 3.38 -0.89 5.95E-01
2538 ARHGDIA 201168 x at 2.1307E-02 9.89E-04 -3.38 -0.89 -4.55E-01
2539 PTPN1 202716 at 2.1307E-02 9.89E-04 -3.38 -0.89 -4.55E-01
2540 235740 at 2.1333E-02 9.92E-04 -3.38 -0.89 -6.09E-01
2541 ARF1 200065 s at 2.1333E-02 9.92E-04 -3.38 -0.89 -4.25E-01
2542 ASRGL1 222764 at 2.1333E-02 9.92E-04 -3.38 -0.89 -2.35E-01
2543 YBPC3 208040 s at 2.1377E-02 9.94E-04 3.38 -0.89 1.93E-01
2544 PLEKH02 204436 at 2.1387E-02 9.95E-04 -3.38 -0.89 -3.84E-01
2545 229108 at 2.1390E-02 9.96E-04 3.38 -0.89 1.51 E-01
2546 KIAA1704 229078 s at 2.1390E-02 9.96E-04 3.38 -0.89 2.31 E-01
2547 HSPB8 221667 s at 2.1390E-02 9.97E-04 -3.38 -0.89 -4.27E-01
2548 PDIA3 229453 at 2.1390E-02 9.97E-04 -3.38 -0.89 -2.40E-01
2549 TMED5 242263 at 2.1390E-02 9.98E-04 -3.38 -0.89 -3.75E-01
2550 OR12D3 221431 s at 2.1390E-02 9.98E-04 -3.38 -0.89 -1.17E-01
2551 PITPNA 201190 s at 2.1424E-02 1.00E-03 -3.38 -0.90 -3.57E-01
2552 HSD11 B1 L 1569905 at 2.1470E-02 1.00E-03 3.38 -0.90 1.84E-01
2553 NUPL1 223984 s at 2.1474E-02 1.00E-03 -3.38 -0.90 -3.07E-01
2554 ODF3 233795 at 2.1479E-02 1.00E-03 3.38 -0.90 2.10E-01
2555 KCNN3 205903 s at 2.1495E-02 1.00E-03 -3.38 -0.90 -2.79E-01
2556 1570134 at 2.1495E-02 1.00E-03 3.38 -0.90 1.05E-01
2557 VAC 14 218169 at 2.1519E-02 1.01 E-03 -3.38 -0.90 -5.05E-01
2558 1560002 at 2.1536E-02 1.01 E-03 3.38 -0.90 1.37E-01
2559 HSPA8 224187 x at 2.1536E-02 1.01 E-03 -3.38 -0.90 -4.57E-01
2560 LANCL2 222560 at 2.1549E-02 1.01 E-03 3.37 -0.90 1.70E-01
2561 ZNF532 220617 s at 2.1549E-02 1.01 E-03 3.37 -0.90 2.40E-01
2562 FILIP1 1556325 at 2.1549E-02 1.01 E-03 -3.37 -0.90 -2.09E-01
2563 RPL23AP82 232899_at 2.1556E-02 1.01 E-03 3.37 -0.91 2.52E-01 ///FA 41C///
RPL23AP7
2564 SMOC2 223235 s at 2.1573E-02 1.01 E-03 -3.37 -0.91 -9.22E-01
2565 KIF21A 231875 at 2.1599E-02 1.01 E-03 -3.37 -0.91 -2.41 E-01
2566 ATF6 203952 at 2.1638E-02 1.02E-03 -3.37 -0.91 -3.14E-01
2567 RBM6 230742 at 2.1638E-02 1.02E-03 3.37 -0.91 4.79E-01
2568 PDE7A 1552343 s at 2.1638E-02 1.02E-03 3.37 -0.91 3.59E-01
2569 ALDH7A1 208950 s at 2.1638E-02 1.02E-03 -3.37 -0.91 -2.91 E-01
No. Gene* Probe ID" Adj. p value P value f B Log FC
2570 RASSF4 221578 at 2.1649E-02 1.02E-03 -3.37 -0.91 -4.77E-01
2571 APOL2 221653 x at 2.1673E-02 1.02E-03 -3.37 -0.91 -4.06E-01
2572 241227 at 2.1673E-02 1.02E-03 3.37 -0.91 2.28E-01
2573 DOLK 204488 at 2.1673E-02 1.02E-03 -3.37 -0.91 -3.06E-01
2574 E2F2 207042 at 2.1675E-02 1.02E-03 3.37 -0.91 1.70E-01
2575 LOC283481 230351 at 2.1675E-02 1.02E-03 3.37 -0.91 1.84E-01
2576 CDR2L 213230 at 2.1675E-02 1.02E-03 -3.37 -0.91 -2.05E-01
2577 FAM20A 242945 at 2.1729E-02 1.02E-03 -3.37 -0.92 -4.58E-01
2578 PRKACB 202741 at 2.1738E-02 1.03E-03 3.37 -0.92 3.03E-01
2579 SLC39A6 1556551 s at 2.1738E-02 1.03E-03 -3.37 -0.92 -4.35E-01
2580 236662 at 2.1746E-02 1.03E-03 -3.37 -0.92 -1.32E-01
2581 232319 at 2.1746E-02 1.03E-03 3.37 -0.92 2.07E-01
2582 CDADC1 233647 s at 2.1746E-02 1.03E-03 3.37 -0.92 2.92E-01
2583 JAM2 229127 at 2.1746E-02 1.03E-03 -3.37 -0.92 -4.82E-01
2584 C9orf135 243610 at 2.1748E-02 1.03E-03 3.37 -0.92 1.37E-01
2585 228773 at 2.1758E-02 1.03E-03 3.37 -0.92 6.87E-01
2586 H19 224997 x at 2.1758E-02 1.03E-03 -3.37 -0.92 -3.84E-01
2587 SLC25A28 221432 s at 2.1763E-02 1.03E-03 -3.37 -0.92 -4.75E-01
2588 ZCRB1 227416 s at 2.1848E-02 1.03E-03 3.37 -0.93 3.12E-01
2589 GART 244822 at 2.1848E-02 1.03E-03 3.37 -0.93 2.53E-01
2590 LOC284933 240754 at 2.1856E-02 1.04E-03 3.37 -0.93 1.96E-01
2591 227069 at 2.1879E-02 1.04E-03 -3.37 -0.93 -2.65E-01
2592 RPL23 214744 s at 2.1879E-02 1.04E-03 3.37 -0.93 6.31 E-01
2593 HSPA2 211538_s_at 2.1881 E-02 1.04E-03 -3.37 -0.93 -4.04E-01
2594 TYMP 204858 s at 2.1924E-02 1.04E-03 -3.37 -0.93 -5.68E-01
2595 MLF1 IP 218883_s_at 2.1924E-02 1.04E-03 3.37 -0.93 6.08E-01
2596 236202 at 2.1924E-02 1.04E-03 3.37 -0.93 2.38E-01
2597 SLC39A6 202088 at 2.1938E-02 1.04E-03 -3.36 -0.93 -3.00E-01
2598 E1F3B 203462 x at 2.1941E-02 1.04E-03 -3.36 -0.93 -5.10E-01
2599 GHRHR 211545 at 2.1943E-02 1.04E-03 3.36 -0.93 1.48E-01
2600 GTDC1 220853 at 2.1945E-02 1.04E-03 3.36 -0.93 1.74E-01
2601 TWIST2 229404 at 2.1945E-02 1.04E-03 -3.36 -0.93 -2.89E-01
2602 NPHP4 213471 at 2.1951 E-02 1.05E-03 -3.36 -0.94 -2.53E-01
2603 LOC100132 229872_s„at 2.1951 E-02 1.05E-03 3.36 -0.94 3.45E-01 999
2604 244075 at 2.1951 E-02 1.05E-03 3.36 -0.94 3.90E-01
2605 MTHFD2L 239562 at 2.1951 E-02 1.05E-03 3.36 -0.94 2.11 E-01
2606 LITAF 200704 at 2.1951 E-02 1.05E-03 -3.36 -0.94 -3.53E-01
2607 CAP1 200625 s at 2.2031 E-02 1.05E-03 -3.36 -0.94 -2.88E-01
2608 RHOB 212099 at 2.2073E-02 1.05E-03 -3.36 -0.94 -7.56E-01
2609 FLJ35776 238432 at 2.2073E-02 1.05E-03 3.36 -0.94 3.24E-01
2610 SELP 206049 at 2.2089E-02 1.05E-03 -3.36 -0.94 -5.22E-01
2611 SLC39A9 216011 at 2.2089E-02 1.05E-03 3.36 -0.94 1.67E-01
2612 CXCL12 203666 at 2.2090E-02 1.06E-03 -3.36 -0.94 -8.27E-01
2613 TMEM182 238867 at 2.2090E-02 1.06E-03 3.36 -0.94 1.91 E-01
2614 GAPDH 217398 x at 2.2107E-02 1.06E-03 -3.36 -0.95 -4.63E-01
2615 CL1C4 201560 at 2.2107E-02 1.06E-03 -3.36 -0.95 -4.48E-01
2616 RPL14P1/// 200074_s_at 2.2132E-02 1.06E-03 3.36 -0.95 2.36E-01 RPL14
2617 CRISPLD2 221541 at 2.2132E-02 1.06E-03 -3.36 -0.95 -1.03E+00
2618 VCL 200931 s at 2.2132E-02 1.06E-03 -3.36 -0.95 -4.95E-01
2619 C11 orf51 204218 at 2.2133E-02 1.06E-03 3.36 -0.95 2.84E-01
2620 GAS7 207704 s at 2.2163E-02 1.06E-03 -3.36 -0.95 -2.58E-01
2621 RHEB 213409 s at 2.2163E-02 1.06E-03 3.36 -0.95 2.61 E-01
2622 VN1 R95P 235322 at 2.2163E-02 1.06E-03 3.36 -0.95 3.28E-01
2623 EPS15 217886 at 2.2163E-02 1.06E-03 -3.36 -0.95 -2.42E-01
2624 LOC401431 229094 at 2.2163E-02 1.06E-03 3.36 -0.95 1.56E-01
2625 CXXC4 220277 at 2.2163E-02 1.06E-03 3.36 -0.95 2.23E-01
2626 ZNF485 1552427 at 2.2163E-02 1.06E-03 3.36 -0.95 1.70E-01
2627 MYO10 201976 s at 2.2163E-02 1.06E-03 -3.36 -0.95 -5.19E-01
2628 TMF1 215855 s at 2.2191 E-02 1.07E-03 3.36 -0.95 2.78E-01
2629 FTSJ2 218356 at 2.2191 E-02 1.07E-03 -3.36 -0.95 -2.58E-01
2630 TARDBP 1558208 at 2.2194E-02 1.07E-03 3.36 -0.95 1.94E-01
2631 IL1 RL1 207526 s at 2.2206E-02 1.07E-03 -3.36 -0.96 -2.09E-01
2632 EXOSC6 1558044 s at 2.2214E-02 1.07E-03 3.36 -0.96 2.40E-01
2633 C21 orf91 220941 s at 2.2256E-02 1.07E-03 3.36 -0.96 5.31 E-01
2634 RXFP2 1553326 at 2.2260E-02 1.07E-03 3.36 -0.96 1.03E-01
2635 CD52 34210 at 2.2268E-02 1.07E-03 3.36 -0.96 5.45E-01
2636 C8orf40 225534 at 2.2268E-02 1.07E-03 3.36 -0.96 5.54E-01
No. Gene* Probe ID** Adj. p value P value t 8 Log FC
2637 ERC1 226049 at 2.2268E-02 1.07E-03 -3.36 -0.96 -3.08E-01
2638 COL6A1 213428 s at 2.2273E-02 1.07E-03 -3.36 -0.96 -9.53E-01
2639 ANGEL2 221826 at 2.2273E-02 1.08E-03 3.36 -0.96 3.54E-01
2640 NBL1 37005 at 2.2299E-02 1.08E-03 -3.35 -0.96 -7.06E-01
2641 C2orf74 1568658 at 2.2299E-02 1 8Ε-03 -3.35 -0.96 -4.12E-01
2642 CFL1 1555730 a at 2.2299E-02 1.08E-03 -3.35 -0.96 -9.91 E-01
2643 ZC3H10 227430 at 2.2299E-02 1.08E-03 -3.35 -0.96 -2.47E-01
2644 NSDHL 209279 s at 2.2299E-02 1.08E-03 -3.35 -0.96 -2.90E-01
2645 237829 at 2.2299E-02 1.08E-03 3.35 -0.96 1.41 E-01
2646 TRIM1 1 228267_at 2.2306E-02 1.08E-03 3.35 -0.96 1.41 E-01
2647 VPS37C 219053 s at 2.2314E-02 1.08E-03 -3.35 -0.96 -3.43E-01
2648 PCCB 212694 s at 2.2332E-02 1.08E-03 -3.35 -0.97 -3.47E-01
2649 CD274 227458_at 2.2332E-02 1.08E-03 -3.35 -0.97 -6.99E-01
2650 216625 at 2.2332E-02 1.08E-03 3.35 -0.97 8.87E-02
2651 231602 at 2.2332E-02 1.08E-03 3.35 -0.97 2.02E-01
2652 MYLK 1563466 at 2.2332E-02 1.08E-03 3.35 -0.97 1.04E-01
2653 C6orf57 238504 at 2.2332E-02 1.08E-03 3.35 -0.97 5.45E-01
2654 LOC100129 1560163_at 2.2356E-02 1.09E-03 3.35 -0.97 1.45E-01 510
2655 ZAK 225662 at 2.2373E-02 1.09E-03 -3.35 -0.97 -4.17E-01
2656 C11orf24 218299 at 2.2373E-02 1.09E-03 -3.35 -0.97 -3.11 E-01
2657 MS4A6A 232725 s at 2.2373E-02 1.09E-03 -3.35 -0.97 -2.17E-01
2658 1562730 a at 2.2373E-02 1.09E-03 3.35 -0.97 1.30E-01
2659 MGAT4B 220189 s at 2.2373E-02 1.09E-03 -3.35 -0.97 -4.87E-01
2660 SERPINH1 207714 s at 2.2375E-02 1.09E-03 -3.35 -0.97 -8.06E-01
2661 C14orf102 227575 s at 2.2375E-02 1.09E-03 -3.35 -0.97 -1.79E-01
2662 C2orf24 207511 s at 2.2375E-02 1.09E-03 -3.35 -0.97 -2.26E-01
2663 SVOPL 1554300 a at 2.2386E-02 1.09E-03 3.35 -0.97 1.29E-01
2664 ITGA9 227297 at 2.2386E-02 1.09E-03 -3.35 -0.97 -5.89E-01
2665 LYRM5 231640 at 2.2386E-02 1.09E-03 3.35 -0.97 2.19E-01
2666 APOE 203381 s at 2.2386E-02 1.09E-03 -3.35 -0.97 -7.96E-01
2667 RHOC 200885 at 2.2386E-02 1.09E-03 -3.35 -0.97 -5.24E-01
2668 SYNCRIP 209024 s at 2.2391 E-02 1.09E-03 -3.35 -0.97 -5.05E-01
2669 PCDHGA1/// 209079_x_at 2.2406E-02 1.09E-03 -3.35 -0.98 -3.34E-01
PCDHGA2///
PCDHGA3///
PCDHGA4///
PCDHGA5///
PCDHGA6///
PCDHGA7///
PCDHGA9///
PCDHGA10/
//PCDHGA1
1///PCDHGB
1///PCDHGB
2///PCDHGB
3W/PCDHGB
5/WPCDHGB
6///PCDHGB
7/WPCDHGC
4/WPCDHGC
5///PCDHGA
12WPCDHG
A8///PCDHG
B4///PCDHG
C3
2670 NRXN3 205795 at 2.2435E-02 1.10E-03 -3.35 -0.98 -1.65E-01
2671 DCN 21 1813 x at 2.2452E-02 1.10E-03 -3.35 -0.98 -1.18E+00
2672 CCDC88C 231288 at 2.2461 E-02 1.10E-03 3.35 -0.98 2.44E-01
2673 LOC100288 1570362_at 2.2475E-02 1.10E-03 3.35 -0.98 1.80E-01 009
2674 IDH1 1555037 a at 2.2502E-02 1.10E-03 -3.35 -0.98 -5.71 E-01
2675 SLC16A2 204462 s at 2.2507E-02 1.10E-03 -3.35 -0.98 -2.79E-01
2676 CYP3A7 243609 at 2.2524E-02 1.10E-03 3.35 -0.98 1.36E-01
2677 RHOQ 212119 at 2.2545E-02 1.10E-03 -3.35 -0.98 -4.27E-01
2678 TIMM23BWL 218119_at 2.2545E-02 1.10E-03 -3.35 -0.98 -5.02E-01 OC10431
2679 MTUS1 212095 s at 2.2574E-02 1.11 E-03 -3.35 -0.99 -4.39E-01
2680 PDLIM4 211564 s at 2.2574E-02 1.11 E-03 -3.35 -0.99 -4.78E-01
2681 GRN 211284 s at 2.2601 E-02 1.11 E-03 -3.35 -0.99 -6.60E-01
No. Gene* Probe ID** Adj. p value P value ί 0 Log FC
2682 T 2D1 212963 at 2.2601 E-02 1.11 E-03 3.35 -0.99 3.01 E-01
2683 EPB41 L3 206710 s at 2.2601 E-02 1.11 E-03 -3.35 -0.99 -8.55E-01
2684 ZNF519 1557283 a at 2.2601 E-02 1.11 E-03 3.35 -0.99 1.41 E-01
2685 HDGF 200896 x at 2.2601 E-02 1.11 E-03 -3.35 -0.99 -4.11 E-01
2686 B3GNT4 221240 s at 2.2601 E-02 1.11 E-03 3.35 -0.99 1.91 E-01
2687 SS18 202816 s at 2.2601 E-02 1.11E-03 -3.35 -0.99 -3.48E-01
2688 C17orf90 221797 at 2.2601 E-02 1.11 E-03 3.35 -0.99 2.35E-01
2689 CRYAB 209283 at 2.2611 E-02 1.11 E-03 -3.35 -0.99 -5.08E-01
2690 GADD45A 203725 at 2.2611 E-02 1.11 E-03 -3.35 -0.99 -4.62E-01
2691 T1 F 213629 x at 2.2620E-02 1.11E-03 -3.34 -0.99 -7.47E-01
2692 239170 at 2.2629E-02 1.11 E-03 3.34 -0.99 2.00E-01
2693 HSF5 230718 at 2.2630E-02 1.11 E-03 3.34 -0.99 3.52E-01
2694 GAS6 202177 at 2.2630E-02 1.12E-03 -3.34 -0.99 -5.59E-01
2695 PAK2 208878 s at 2.2630E-02 1.12E-03 -3.34 -0.99 -3.07E-01
2696 CTTN 201059 at 2.2630E-02 1.12E-03 -3.34 -0.99 -5.34E-01
2697 RGS10 214000 s at 2.2639E-02 1.12E-03 3.34 -0.99 4.42E-01
2698 C10orf46 227257 s at 2.2639E-02 1.12E-03 -3.34 -0.99 -5.80E-01
2699 GGTA1 228376 at 2.2669E-02 1.12E-03 -3.34 -1.00 -5.11 E-01
2700 ZBTB25 214482 at 2.2669E-02 1.12E-03 3.34 -1.00 3.92E-01
2701 233698 at 2.2672E-02 1.12E-03 3.34 -1.00 1.71E-01
2702 GSN 214040 s at 2.2700E-02 1.12E-03 -3.34 -1.00 -3.49E-01
2703 ADCK2 44120 at 2.2700E-02 1.12E-03 -3.34 -1.00 -2.73E-01
2704 PHKB 202739 s at 2.2713E-02 1.12E-03 -3.34 -1.00 -3.40E-01
2705 DNAJB5 207453 s at 2.2713E-02 1.12E-03 -3.34 -1.00 -1.84E-01
2706 CP 227253 at 2.2716E-02 1.12E-03 -3.34 -1.00 -6.88E-01
2707 TRI 49 221154 at 2.2723E-02 1.13E-03 3.34 -1.00 1.18E-01
2708 242366 at 2.2723E-02 1.13E-03 -3.34 -1.00 -3.69E-01
2709 RPS15 200819 s at 2.2736E-02 1.13E-03 3.34 -1.00 1.69E-01
2710 ATP6V0D1 212041 at 2.2739E-02 1.13E-03 -3.34 -1.00 -5.41 E-01
271 1 LACTB 1552486 s at 2.2742E-02 1.13E-03 -3.34 -1.00 -6.88E-01
2712 NCRNA001 220399_at 2.2742E-02 1.13E-03 3.34 -1.00 2.47E-01 15
2713 FEM1 B 212367 at 2.2748E-02 1.13E-03 -3.34 -1.00 -2.83E-01
2714 RPS19 202649 x at 2.2759E-02 1.13E-03 3.34 -1.00 1.56E-01
2715 TAX1 BP3 215464 s at 2.2771 E-02 1.13E-03 -3.34 -1.01 -6.30E-01
2716 T EM164 223201 s at 2.2777E-02 1.13E-03 -3.34 -1.01 -2.24E-01
2717 SERBP1 217724 at 2.281 OE-02 1.13E-03 -3.34 -1.01 -2.94E-01
2718 SPTLC2 203128 at 2.281 OE-02 1.13E-03 -3.34 -1.01 -2.23E-01
2719 LOC728153 1560199 x at 2.2901 E-02 1.14E-03 3.34 -1.01 3.01 E-01
2720 FA 55D 220645 at 2.2901 E-02 1.14E-03 3.34 -1.01 1.54E-01
2721 NKAIN4 230771 at 2.2922E-02 1.1 E-03 3.34 -1.01 1.42E-01
2722 FA 65A 45749 at 2.2922E-02 1.14E-03 -3.34 -1.01 -2.91 E-01
2723 ENPEP 204844 at 2.2922E-02 1.14E-03 -3.34 -1.01 -3.21 E-01
2724 AZI2 227905 s at 2.2924E-02 1.14E-03 -3.34 -1.01 -2.63E-01
2725 A DAM 7 239079 at 2.2924E-02 1.14E-03 3.34 -1.01 1.42E-01
2726 LIME1 219541 at 2.2942E-02 1.14E-03 3.34 -1.02 3.03E-01
2727 BTN3A3 204821 at 2.2942E-02 1.14E-03 -3.34 -1.02 -4.50E-01
2728 237791 at 2.2946E-02 1.14E-03 3.34 -1.02 1.29E-01
2729 RWDD3 205087 at 2.2966E-02 1.15E-03 3.34 -1.02 4.76E-01
2730 ZRANB2 223016 x at 2.3042E-02 1.15E-03 3.33 -1.02 2.38E-01
2731 PPAP2A 209147 s at 2.3042E-02 1.15E-03 -3.33 -1.02 -4.88E-01
2732 PDCD1 LG2 220049 s at 2.3076E-02 1.15E-03 -3.33 -1.02 -4.06E-01
2733 239808 at 2.3150E-02 1.16E-03 3.33 -1.03 3.16E-01
2734 LIMK2 210582 s at 2.3175E-02 1.16E-03 -3.33 -1.03 -4.43E-01
2735 UBIAD1 229348 at 2.3188E-02 1.16E-03 3.33 -1.03 2.28E-01
2736 PRELID1 223032 x at 2.3188E-02 1.16E-03 -3.33 -1.03 -3.42E-01
2737 ZNF292 212366 at 2.3188E-02 1.16E-03 3.33 -1.03 2.99E-01
2738 MME 203434 s at 2.3191 E-02 1.16E-03 -3.33 -1.03 -9.53 E-01
2739 TMEM126B 1554537 at 2.3194E-02 1.16E-03 3.33 -1.03 1.74E-01
2740 SNRPE 215450 at 2.3 95E-02 1. 6E-03 3.33 -1.03 5.52E-01
2741 237459 at 2.3214E-02 1.16E-03 3.33 -1.03 2.02E-01
2742 PQLC1 218208 at 2.3214E-02 1.16E-03 -3.33 -1.03 -2.72E-01
2743 SRP72 208800 at 2.3227E-02 1.17E-03 -3.33 -1.03 -4.82E-01
2744 LAMP1 213728 at 2.3227E-02 1.17E-03 -3.33 -1.03 -2.30E-01
2745 HIST1H3D/// 214522_x_at 2.3229E-02 1.17E-03 3.33 -1.03 4.51 E-01 HIST1H2AD
2746 SENP5 222110 at 2.3230E-02 1.17E-03 3.33 -1.03 1.50E-01
2747 C20orf108 224690 at 2.3230E-02 1.17E-03 -3.33 -1.03 -4.09E-01
2748 IRAK3 213817 at 2.3230E-02 1.17E-03 -3.33 -1.03 -4.50E-01
6B
No. Gene* Probe ID** Adj. p value P value t B Log FC
2749 DNM1 L 203105 s at 2.3260E-02 1.17E-03 -3.33 -1.03 -3.05E-01
2750 C1 orf156 213528 at 2.3260E-02 1.17E-03 3.33 -1.04 4.29E-01
2751 OCIAD2 225314 at 2.3262E-02 1.17E-03 3.33 -1.04 5.12E-01
2752 ERI1 231852 at 2.3267E-02 1.17E-03 -3.33 -1.04 -1.90E-01
2753 STXBP1 202260 s at 2.3267E-02 1.17E-03 -3.33 -1.04 -4.00E-01
2754 235959 at 2.3273E-02 1.17E-03 3.33 -1.04 3.03E-01
2755 MP14 202827 s at 2.3275E-02 1.17E-03 -3.33 -1.04 -4.20E-01
2756 YLPM1 1557065 at 2.3275E-02 1.17E-03 3.33 -1.04 3.20E-01
2757 SLC03A1 210542 s at 2.3275E-02 1.17E-03 -3.33 -1.04 -2.42E-01
2758 PIAS4 212881 at 2.3275E-02 1.18E-03 -3.33 -1.04 -2.93E-01
2759 SLC2A3 202498 s at 2.3275E-02 1.18E-03 -3.33 -1.04 -4.14E-01
2760 A2M 217757 at 2.3275E-02 1.18E-03 -3.33 -1.04 -4.87E-01
2761 BSG 208677 s at 2.3275E-02 1.18E-03 -3.33 -1.04 -4.99E-01
2762 T1G 204745 x at 2.3275E-02 1.18E-03 -3.33 -1.04 -9.22E-01
2763 KDM1 B 1553150 at 2.3275E-02 1.18E-03 -3.33 -1.04 -1.71 E-01
2764 CCDC59 222792 s at 2.3278E-02 1.18E-03 3.33 -1.04 3.90E-01
2765 PARVG 244229 at 2.3287E-02 1.18E-03 3.33 -1.04 3.76E-01
2766 KIAA0100 201729 s at 2.3318E-02 1.18E-03 -3.33 -1.04 -5.22E-01
2767 WHSC2 203112 s at 2.3318E-02 1.18E-03 -3.33 -1.04 -3.03E-01
2768 RHOU 223168 at 2.3339E-02 1.18E-03 -3.33 -1.04 -6.00E-01
2769 213739_at 2.3339E-02 1.18E-03 3.33 -1.04 1.64E-01
2770 233401_at 2.3356E-02 1.18E-03 3.33 -1.05 1.41E-01
2771 C10orf18 1556758 at 2.3357E-02 1.18E-03 3.33 -1.05 1.47E-01
2772 SENP6 214790 at 2.3378E-02 1.19E-03 3.33 -1.05 3.22E-01
2773 ZHX3 212545 s at 2.3378E-02 1.19E-03 3.33 -1.05 2.13E-01
2774 YAF2 206238 s at 2.3378E-02 1.19E-03 3.33 -1.05 4.95E-01
2775 242692 at 2.3378E-02 1.19E-03 3.33 -1.05 1.59E-01
2776 GJA3 208590 x at 2.3402E-02 1.19E-03 3.32 -1.05 1.51 E-01
2777 243782 at 2.3403E-02 1.19E-03 3.32 -1.05 1.76E-01
2778 NDUFA3 218563 at 2.3443E-02 1.19E-03 3.32 -1.05 2.49E-01
2779 1557495_at 2.3453E-02 1.19E-03 3.32 -1.05 1.15E-01
2780 DCN 201893 x at 2.3464E-02 1.19E-03 -3.32 -1.05 -1.13E+00
2781 RPS4X 200933_x_at 2.3464E-02 1.19E-03 3.32 -1.05 1.34E-01
2782 FKBP11 228308 at 2.3502E-02 1.20E-03 -3.32 -1.05 -3.86E-01
2783 238305 at 2.3517E-02 1.20E-03 3.32 -1.06 9.56E-02
2784 1562010 x at 2.3550E-02 1.20E-03 3.32 -1.06 1.47E-01
2785 239215 at 2.3550E-02 1.20E-03 3.32 -1.06 1.69E-01
2786 CHMP4B 225498 at 2.3562E-02 1.20E-03 -3.32 -1.06 -3.73E-01
2787 FBX045 225099 at 2.3562E-02 1.20E-03 -3.32 -1.06 -3.55E-01
2788 243798 at 2.3562E-02 1.20E-03 3.32 -1.06 6.12E-01
2789 215386 at 2.3569E-02 1.20E-03 3.32 -1.06 1.55E-01
2790 NCRNA002 234954_at 2.3569E-02 1.20E-03 -3.32 -1.06 -3.68E-01 71///GAPDH
L19
2791 UBQLN1 222990 at 2.3572E-02 1.20E-03 -3.32 -1.06 -2.65E-01
2792 GLP1 R 211232 x at 2.3613E-02 1.21 E-03 3.32 -1.06 1.62E-01
2793 RDX 212398 at 2.3618E-02 1.21E-03 -3.32 -1.06 -4.45E-01
2794 CCDC11 1552326 a at 2.3629E-02 1.21 E-03 3.32 -1.06 1.64E-01
2795 PABPN1 201544 x at 2.3632E-02 1.21 E-03 -3.32 -1.06 -5.13E-01
2796 LAPTM4B 1554679 a at 2.3633E-02 1.21 E-03 -3.32 -1.06 -3.72E-01
2797 ACAD9 224160 s at 2.3644E-02 1.21 E-03 -3.32 -1.06 -2.84E-01
2798 HIP1 205425 at 2.3644E-02 1.21 E-03 -3.32 -1.07 -2.62E-01
2799 FZR1 209415 at 2.3681 E-02 1.21 E-03 3.32 -1.07 1.90E-01
2800 ATP8A2 219660 s at 2.3681 E-02 1.21 E-03 3.32 -1.07 4.99E-01
2801 INHA 210141 s at 2.3698E-02 1.21 E-03 3.32 -1.07 1.63E-01
2802 AKR1A1 241978 at 2.3702E-02 1.21 E-03 3.32 -1.07 2.01 E-01
2803 241095 at 2.3702E-02 1.22E-03 3.32 -1.07 1.48E-01
2804 ALG1 223355 at 2.3702E-02 1.22E-03 -3.32 -1.07 -1.82E-01
2805 234067 at 2.3702E-02 1.22E-03 3.32 -1.07 1.37E-01
2806 A2ML1 1564307 a at 2.3713E-02 1.22E-03 3.32 -1.07 1.25E-01
2807 GUSB 202605 at 2.3755E-02 1.22E-03 -3.32 -1.07 -2.42E-01
2808 KCTD11 235857 at 2.3771 E-02 1.22E-03 -3.32 -1.07 -3.18E-01
2809 PREB 217861 s at 2.3781 E-02 1.22E-03 -3.32 -1.07 -3.13E-01
2810 RRAGA 201628 s at 2.3787E-02 1.22E-03 -3.32 -1.07 -4.14E-01
2811 230366 at 2.3822E-02 1.23E-03 3.32 -1.08 1.31 E-01
2812 TBC1 D9B 212052 s at 2.3822E-02 1.23E-03 -3.32 -1.08 -4.06E-01
2813 SLC29A1 201801 s at 2.3822E-02 1.23E-03 -3.32 -1.08 -3.97E-01
2814 CLLU1 1558186 s at 2.3822E-02 1.23E-03 3.32 -1.08 6.09E-01
2815 1560500 at 2.3822E-02 1.23E-03 3.32 -1.08 1.77E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
2816 XRN2 233878 s at 2.3822E-02 1.23E-03 -3.32 -1.08 -7.30E-01
2817 TP 3 222976 s at 2.3822E-02 1.23E-03 -3.32 -1.08 -2.76E-01
2818 PP5 226092 at 2.3826E-02 1.23E-03 -3.31 -1.08 -2.88E-01
2819 HGS AT 222491 at 2.3826E-02 1.23E-03 -3.31 -1.08 -2.13E-01
2820 CHST3 209834 at 2.3826E-02 1.23E-03 -3.31 -1.08 -2.19E-01
2821 CH25H 206932 at 2.3836E-02 1.23E-03 -3.31 -1.08 -5.72E-01
2822 KCNG3 1552897_a_at 2.3836E-02 1.23E-03 3.31 -1.08 1.10E-01
2823 SLC2A10 221024 s at 2.3855E-02 1.23E-03 -3.31 -1.08 -7.05E-01
2824 ANKRD13A 238851 at 2.3881 E-02 1.23E-03 3.31 -1.08 2.87E-01
2825 SLC4A1AP 242030_at 2.3885E-02 1.23E-03 3.31 -1.08 2.25E-01
2826 C7orf30 226385_s_at 2.3885E-02 1.23E-03 3.31 -1.08 2.77E-01
2827 239341_at 2.3886E-02 1.24E-03 3.31 -1.08 2.01 E-01
2828 COQ10B 219397_at 2.3902E-02 1.24E-03 3.31 -1.08 3.44E-01
2829 ARL8A 1556155 at 2.3941 E-02 1.24E-03 3.31 -1.09 1.40E-01
2830 232236 at 2.3951 E-02 1.24E-03 3.31 -1.09 1.84E-01
2831 AP1 G1 203350 at 2.3971 E-02 1.24E-03 -3.31 -1.09 -4.03E-01
2832 PALLD 200906 s at 2.3971 E-02 1.24E-03 -3.31 -1.09 -5.08E-01
2833 242932 at 2.3971 E-02 1.24E-03 3.31 -1.09 2.14E-01
2834 232582 at 2.4011 E-02 1.24E-03 3.31 -1.09 1.23E-01
2835 ZNF710 235090 at 2.4028E-02 1.25E-03 3.31 -1.09 1.55E-01
2836 ATP6V1A 201971_s_at 2.4028E-02 1.25E-03 -3.31 -1.09 -6.64E-01
2837 ADCY1 213245 at 2.4028E-02 1.25E-03 -3.31 -1.09 -3.53E-01
2838 NFKB2 211524 at 2.4028E-Q2 1.25E-03 3.31 -1.09 1.26E-01
2839 IARS 204744 s at 2.4028E-02 1.25E-03 -3.31 -1.09 -2.94E-01
2840 YST2 200049 at 2.4028E-02 1.25E-03 -3.31 -1.09 -4.18E-01
2841 STAU1 211505 s at 2.4028E-02 1.25E-03 -3.31 -1.09 -5.36E-01
2842 233214 at 2.4028E-02 1.25E-03 3.31 -1.09 2.04E-01
2843 FA 114A1 226697 at 2.4028E-02 1.25E-03 -3.31 -1.09 -5.68E-01
2844 F NL2 242665 at 2.4049E-02 1.25E-03 -3.31 -1.09 -5.11 E-01
2845 NKD2 232201 at 2.4067E-02 1.25E-03 -3.31 -1.10 -2.34E-01
2846 F NL2 226184 at 2.4067E-02 1.25E-03 -3.31 -1.10 -5.25E-01
2847 PACSIN2 1554691 a at 2.4073E-02 1.25E-03 -3.31 -1.10 -3.31 E-01
2848 RPL24 200013 at 2.4080E-02 1.25E-03 3.31 -1.10 2.95E-01
2849 LOC100287 231390_at 2.4120E-02 1.26E-03 3.31 -1.10 1.55E-01 426
2850 RASSF4 226436 at 2.4120E-Q2 1.26E-03 -3.31 -1.10 -5.37E-01
2851 RDX 212397 at 2.4120E-02 1.26E-03 -3.31 -1.10 -4.05E-01
2852 C6orf97 220581 at 2.4122E-02 1.26E-03 -3.31 -1.10 -1.28E-01
2853 TRPV2 222855 s at 2.4122E-02 1.26E-03 -3.31 -1.10 -2.30E-01
2854 1569114 at 2.4122E-02 1.26E-03 3.31 -1.10 1.29E-01
2855 231383 at 2.4126E-02 1.26E-03 3.31 -1.10 1.44E-01
2856 1562044 at 2.4144E-02 1.26E-03 3.31 -1.10 1.43E-01
2857 CP 208649 s at 2.4146E-02 1.26E-03 -3.31 -1.10 -5.13E-01
2858 239298 at 2.4148E-Q2 1.26E-03 3.31 -1.10 1.17E-01
2859 XRCC5 232633 at 2.4148E-02 1.26E-03 3.31 -1.10 2.39E-01
2860 CCDC47 222432 s at 2.4148E-Q2 1.26E-03 -3.31 -1.10 -3.48E-01
2861 COPS8 202141 s at 2.4148E-02 1.27E-03 -3.31 -1.10 -2.72E-01
2862 AGFG1 218092 s at 2.4148E-02 1.27E-03 -3.31 -1.11 -3.14E-01
2863 FA 82A2 218126 at 2.4148E-02 1.27E-03 -3.31 -1.11 -2.55E-01
2864 ADORA2A 205013 s at 2.4148E-02 1.27E-03 3.31 -1.11 3.55E-01
2865 USP4 211800 s at 2.4148E-02 1.27E-03 -3.31 -1.11 -3.19E-01
2866 DNAH1 228112 at 2.4148E-02 1.27E-03 3.31 -1.11 1.67E-01
2867 PFKL 211065 x at 2.4148E-02 1.27E-03 -3.31 -1.11 -2.78E-01
2868 235814 at 2.4148E-Q2 1.27E-03 3.31 -1.11 1.84E-01
2869 COL27A1 225288 at 2.4148E-02 1.27E-03 -3.30 -1.11 -3.62E-01
2870 T1 H 206461 x at 2.4148E-02 1.27E-03 -3.30 -1.11 -8.49E-01
2871 234434 at 2.4148E-Q2 1.27E-03 3.30 -1.11 1.40E-01
2872 HO ER3 215489 x at 2.4148E-Q2 1.27E-03 -3.30 -1.11 -2.52E-01
2873 FADS1 208964 s at 2.4148E-Q2 1.27E-03 -3.30 -1.11 -4.07E-01
2874 239252 at 2.4148E-02 1.27E-03 3.30 -1.11 3.80E-01
2875 239452 at 2.4148E-02 1.27E-03 -3.30 -1.11 -1.25E-01
2876 SLC28A1 231187 at 2.4148E-Q2 1.27E-03 3.30 -1.11 1.44E-01
2877 USP9X 230543 at 2.4148E-Q2 1.27E-03 -3.30 -1.11 -1.51 E-01
2878 PRR16 220014 at 2.4148E-02 1.27E-03 -3.30 -1.11 -5.93E-01
2879 LHFPL2 212658 at 2.4148E-02 1.27E-03 -3.30 -1.11 -5.52E-01
2880 GNAS 217058 at 2.4148E-02 1.27E-03 3.30 -1.11 1.91 E-01
2881 SRSF2IP 232597 x at 2.4179E-02 1.27E-03 3.30 -1.11 3.96E-01
2882 242264 at 2.4179E-02 1.27E-03 3.30 -1.11 2.95E-01
2883 S1 PR2 227684 at 2.4186E-02 1.28E-03 -3.30 -1.11 -2.39E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
2884 GK5 238121 at 2.4194E-02 1.28E-03 -3.30 -1.11 -1.39E-01
2885 HCG27 1559050 at 2.4200E-02 1.28E-03 3.30 -1.11 2.18E-01
2886 JDP2 239085 at 2.4216E-02 1.28E-03 3.30 -1.11 1.47E-01
2887 RREB1 228487 s at 2.4227E-02 1.28E-03 -3.30 -1.11 -4.40E-01
2888 241846 at 2.4228E-02 1.28E-03 3.30 -1.12 1.48E-01
2889 O G 207093 s at 2.4228E-02 1.28E-03 3.30 -1.12 1.44E-01
2890 TPR 228709 at 2.4228E-02 1.28E-03 3.30 -1.12 4.20E-01
2891 QRSL1 233089 at 2.4228E-02 1.28E-03 3.30 -1.12 3.01 E-01
2892 238750 at 2.4228E-02 1.28E-03 3.30 -1.12 3.93E-01
2893 FLJ41649 1562219 at 2.4237E-02 1.28E-03 3.30 -1.12 1.40E-01
2894 228560 at 2.4237E-02 1.28E-03 3.30 -1.12 1.99E-01
2895 NPPB 206801 at 2.4263E-02 1.28E-03 3.30 -1.12 1.77E-01
2896 CSNK1 D 207945 s at 2.4273E-02 1.29E-03 -3.30 -1.12 -4.47E-01
2897 UBE2L3 200676 s at 2.4279E-02 1.29E-03 -3.30 -1.12 -4.33E-01
2898 ACTB 213867 x at 2.4285E-02 1.29E-03 -3.30 -1.12 -3.73E-01
2899 RNASEK 224573 at 2.4308E-02 1.29E-03 -3.30 -1.12 -4.80E-01
2900 PEX26 235098 at 2.431 OE-02 1.29E-03 3.30 -1.12 1.60E-01
2901 LOX 204298 s at 2.4315E-02 1.29E-03 -3.30 -1.12 -9.33E-01
2902 CCR2 207794 at 2.4317E-02 1.29E-03 -3.30 -1.12 -3.10E-01
2903 2NF383 235414 at 2.4319E-02 1.29E-03 3.30 -1.12 2.88E-01
2904 RNF130 217865 at 2.4319E-02 1.29E-03 -3.30 -1.12 -5.86E-01
2905 STK17B 205214 at 2.4319E-02 1.29E-03 3.30 -1.12 4.57E-01
2906 NCF4 205147 x at 2.4320E-02 1.29E-03 -3.30 -1.12 -4.92E-01
2907 EIS3P1 214077_x_at 2.4330E-02 1.29E-03 -3.30 -1.12 -3.55E-01
2908 TERF2 203611_at 2.4356E-02 1.30E-03 -3.30 -1.13 -4.96E-01
2909 CAST 208908_s_at 2.4356E-02 1.30E-03 -3.30 -1.13 -4.20E-01
2910 CXorf57 215803 at 2.4356E-02 1.30E-03 3.30 -1.13 8.04E-02
2911 TARDBP 221264 s at 2.4358E-02 1.30E-03 3.30 -1.13 5.14E-01
2912 APPL2 218218 at 2.4370E-02 1.30E-03 -3.30 -1.13 -4.24E-01
2913 242379 at 2.4373E-02 1.30E-03 3.30 -1.13 1.34E-01
2914 YOF 201798 s at 2.4379E-02 1.30E-03 -3.30 -1.13 -6.97E-01
2915 SE A4A 219259 at 2.4381 E-02 1.30E-03 -3.30 -1.13 -4.72E-01
2916 LHFPL4 228422 at 2.4386E-02 1.30E-03 3.30 -1.13 1.80E-01
2917 CREB5 205931 s at 2.4386E-02 1.30E-03 -3.30 -1.13 -1.69E-01
2918 TFPI 213258 at 2.4386E-02 1.30E-03 -3.30 -1.13 -5.56E-01
2919 SEC13 207707 s at 2.4386E-02 1.30E-03 -3.30 -1.13 -3.15E-01
2920 PPP1 R7 201214 s at 2.4407E-02 1.30E-03 -3.30 -1.13 -4.39E-01
2921 SEC23B 210293 s at 2.4439E-02 1.31 E-03 -3.30 -1.13 -2.36E-01
2922 LF1 IP 229305 at 2.4502E-02 1.31 E-03 3.30 -1.14 3.91 E-01
2923 DPYSL3 201431 s at 2.4502E-02 1.31 E-03 -3.30 -1.14 -6.70E-01
2924 SLC39A6 1555460 a at 2.4509E-02 1.31 E-03 -3.29 -1.14 -3.62E-01
2925 2NF638 211257 x at 2.4538E-02 1.31 E-03 -3.29 -1.14 -4.45E-01
2926 P4HA2 202733 at 2.4561 E-02 1.31 E-03 -3.29 -1.14 -8.41 E-01
2927 ALAD 218487 at 2.4570E-02 1.32E-03 -3.29 -1.14 -2.80E-01
2928 1558784 at 2.4575E-02 1.32E-03 3.29 -1.14 2.92E-01
2929 STAT3 208991 at 2.4576E-02 1.32E-03 -3.29 -1.14 -5.50E-01
2930 244670 at 2.4580E-02 1.32E-03 3.29 -1.14 1.14E-01
2931 REEP5 208872 s at 2.4611 E-02 1.32E-03 -3.29 -1.14 -3.69E-01
2932 ATP6V0C 36994 at 2.4632E-02 1.32E-03 -3.29 -1.14 -4.94E-01
2933 C20orf27 218081 at 2.4654E-02 1.32E-03 -3.29 -1.14 -2.19E-01
2934 T PO 209754 s at 2.4677E-02 1.32E-03 3.29 -1.14 3.50E-01
2935 LILRA6///LIL 211133_x_at 2.4677E-02 1.33E-03 -3.29 -1.15 -4.15E-01 RB3
2936 SFRP5 207468 s at 2.4677E-02 1.33E-03 3.29 -1.15 1.51 E-01
2937 IT 2B 217732 s at 2.4687E-02 1.33E-03 -3.29 -1.15 -3.02E-01
2938 CFHR2 206910 x at 2.4695E-02 1.33E-03 -3.29 -1.15 -2.27E-01
2939 1557521 a at 2.4695E-02 1.33E-03 3.29 -1.15 2.69E-01
2940 BACE1 224335 s at 2.4695E-02 1.33E-03 -3.29 -1.15 -2.25E-01
2941 TTC39C 230747 s at 2.4695E-02 1.33E-03 3.29 -1.15 4.67E-01
2942 RBP S 207836 s at 2.4695E-02 1.33E-03 -3.29 -1.15 -3.72E-01
2943 238785 at 2.4695E-02 1.33E-03 3.29 -1.15 2.07E-01
2944 EPB41 L4B 220524 at 2.4720E-02 1.33E-03 3.29 -1.15 1.44E-01
2945 PTGIS 211892 s at 2.4755E-02 1.33E-03 -3.29 -1.15 -1.80E-01
2946 RHOQ 212122 at 2.4759E-02 1.33E-03 -3.29 -1.15 -4.07E-01
2947 TXNIP 201008 s at 2.4784E-02 1.34E-03 -3.29 -1.15 -5.71 E-01
2948 CCDC124 225454 at 2.4784E-02 1.34E-03 -3.29 -1.15 -2.85E-01
2949 YWHAB 217717 s at 2.4796E-02 1.34E-03 -3.29 -1.15 -4.33E-01
2950 USP9X 229573 at 2.4808E-02 1.34E-03 3.29 -1.15 2.73E-01
2951 2NF346 236267 at 2.481 OE-02 1.34E-03 3.29 -1.15 3.25E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
2952 MTF2 209705 at 2.4825E-02 1.34E-03 3.29 -1.16 2.61 E-01
2953 LOC646522 237662 at 2.4825E-02 1.34E-03 3.29 -1.16 1.74E-01
2954 LRRC2 219949 at 2.4829E-02 1.34E-03 -3.29 -1.16 -1.46E-01
2955 221138 s at 2.4840E-02 1.34E-03 3.29 -1.16 1.29E-01
2956 MUTED 226544 x at 2.4899E-02 1.35E-03 3.29 -1.16 2.21 E-01
2957 241010 x at 2.4956E-02 1.35E-03 3.29 -1.16 1.94E-01
2958 ASAP1 221039 s at 2.4956E-02 1.35E-03 -3.29 -1.16 -6.60E-01
2959 1570496 at 2.4956E-02 1.35E-03 3.29 -1.16 1.32E-01
2960 FBP1 209696 at 2.4960E-02 1.35E-03 -3.29 -1.16 -8.63E-01
2961 PEX13 1558163 at 2.4987E-02 1.35E-03 3.28 -1.16 1.26E-01
2962 ABL2 226893 at 2.4987E-02 1.35E-03 -3.28 -1.16 -3.10E-01
2963 1554108 at 2.4987E-02 1.35E-03 3.28 -1.16 1.97E-01
2964 COL6A6 230867 at 2.4987E-02 1.35E-03 -3.28 -1.16 -1.17E+00
2965 230667 at 2.4989E-02 1.36E-03 3.28 -1.17 2.12E-01
2966 243107 at 2.4989E-02 1.36E-03 3.28 -1.17 3.04E-01
2967 220827 at 2.4989E-02 1.36E-03 3.28 -1.17 1.64E-01
2968 SNHG1 224610 at 2.5014E-02 1.36E-03 3.28 -1.17 5.05E-01
2969 239788 at 2.5020E-02 1.36E-03 3.28 -1.17 2.60E-01
2970 UXT 218495 at 2.5043E-02 1.36E-03 3.28 -1.17 4.68E-01
2971 THY1 208850 s at 2.5043E-02 1.36E-03 -3.28 -1.17 -6.09E-01
2972 235943 at 2.5055E-02 1.36E-03 3.28 -1.17 1.36E-01
2973 230725 at 2.5077E-02 1.36E-03 3.28 -1.17 1.64E-01
2974 1564468 at 2.5087E-02 1.36E-03 3.28 -1.17 9.60E-02
2975 DNAJC24 213853 at 2.5118E-02 1.37E-03 3.28 -1.17 2.44E-01
2976 ZNF689 227445 at 2.5118E-02 1.37E-03 -3.28 -1.17 -3.99E-01
2977 ESAM 225369 at 2.5120E-02 1.37E-03 -3.28 -1.17 -2.80E-01
2978 DHRS7 210788 s at 2.5120E-02 1.37E-03 -3.28 -1.17 -4.07E-01
2979 231350 at 2.5120E-02 1.37E-03 3.28 -1.17 1.44E-01
2980 MDFIC 239172 x at 2.5120E-02 1.37E-03 3.28 -1.17 1.52E-01
2981 RLN2 214519 s at 2.5129E-02 1.37E-03 3.28 -1.18 7.53E-01
2982 PAPSS1 209043 at 2.5130E-02 1.37E-03 -3.28 -1.18 -4.00E-01
2983 PDE4D 204491 at 2.5138E-02 1.37E-03 3.28 -1.18 3.46E-01
2984 IL10RA 204912 at 2.5148E-02 1.37E-03 -3.28 -1.18 -3.67E-01
2985 MLXIP 202519 at 2.5152E-02 1.37E-03 -3.28 -1.18 -5.35E-01
2986 1569167 at 2.5155E-02 1.37E-03 3.28 -1.18 1.48E-01
2987 PTGFRN 224937 at 2.5198E-02 1.38E-03 -3.28 -1.18 -7.42E-01
2988 GNS 212334 at 2.5198E-02 1.38E-03 -3.28 -1.18 -5.87E-01
2989 HPS6 219052 at 2.5198E-02 1.38E-03 -3.28 -1.18 -2.24E-01
2990 NHEDC1 1553633 s at 2.5202E-02 1.38E-03 3.28 -1.18 1.80E-01
2991 GMFG 204220 at 2.5202E-02 1.38E-03 3.28 -1.18 5.05E-01
2992 TOM1 202807 s at 2.5202E-02 1.38E-03 -3.28 -1.18 -3.55E-01
2993 FLJ90757 1558147 a at 2.5232E-02 1.38E-03 3.28 -1.18 1.40E-01
2994 EDN1 222802 at 2.5232E-02 1.38E-03 -3.28 -1.18 -3.58E-01
2995 DDX21 224654 at 2.5232E-02 1.38E-03 -3.28 -1.18 -2.59E-01
2996 TM9SF4 212194 s at 2.5232E-02 1.38E-03 -3.28 -1.18 -5.40E-01
2997 AGTRAP 1555736 a at 2.5232E-02 1.38E-03 -3.28 -1.18 -5.65E-01
2998 TBC1 D9B 206431 x at 2.5232E-02 1.38E-03 -3.28 -1.18 -3.00E-01
2999 EDNRB 206701 x at 2.5232E-02 1.38E-03 -3.28 -1.18 -4.02E-01
3000 239682 at 2.5257E-02 1.39E-03 3.28 -1.19 1.66E-01
3001 NUDT19 235384 at 2.5263E-02 1.39E-03 -3.28 -1.19 -3.59E-01
3002 NFE2L1 200758 s at 2.5268E-02 1.39E-03 -3.28 -1.19 -3.86E-01
3003 VAMP3 201337 s at 2.5271 E-02 1.39E-03 -3.28 -1.19 -5.84E-01
3004 ZDHHC13 219296 at 2.5271 E-02 1.39E-03 3.28 -1.19 5.56E-01
3005 GLB1 201576 s at 2.5286E-02 1.39E-03 -3.28 -1.19 -3.91 E-01
3006 GRN 200678 x at 2.5337E-02 1.39E-03 -3.28 -1.19 -6.64E-01
3007 ROGDl 218394 at 2.5337E-02 1.39E-03 -3.28 -1.19 -1.91 E-01
3008 CANT1 1554327 a at 2.5337E-02 1.39E-03 -3.28 -1.19 -1.73E-01
3009 NID1 202007 at 2.5366 E-02 1.40E-03 -3.28 -1.19 -7.88E-01
3010 237337 at 2.5366E-02 1.40E-03 3.28 -1.19 2.47E-01
3011 MXD3 221250 s at 2.5366E-02 1.40E-03 3.28 -1.19 1.97E-01
3012 GLMN 207153 s at 2.5366E-02 1.40E-03 3.28 -1.19 4.11 E-01
3013 NCRNA002 231196_x_at 2.541 OE-02 1.40E-03 3.27 -1.19 1.36E-01 02
3014 ARL6IP5 200760 s at 2.5423E-02 1.40E-03 -3.27 -1.20 -2.99E-01
3015 LOC100134 211835_at 2.5423E-02 1.40E-03 -3.27 -1.20 -4.00E-01
331///LOC10
0126583///L
OC652128///
LOC642131/
No. Gene* Probe ID** Adj. p value P value f B Log FC
3076 URGCP 244046 at 2.5876E-02 1.46E-03 3.26 -1.23 3.33E-01
3077 SH3BGRL3 221269 s at 2.5876E-02 1.46E-03 -3.26 -1.23 -6.04E-01
3078 RB 47 218035 s at 2.5876E-02 1.46E-03 -3.26 -1.23 -4.69E-01
3079 TP 4 209344 at 2.5876E-02 1.46E-03 -3.26 -1.23 -4.85E-01
3080 SE A6D 233882 s at 2.5884E-02 1.46E-03 -3.26 -1.23 -1.54E-01
3081 GNB4 223487 x at 2.5903E-02 1.46E-03 -3.26 -1.23 -3.04E-01
3082 PAK1 209615 s at 2.5934E-02 1.46E-03 -3.26 -1.23 -2.77E-01
3083 NOTCH2 212377 s at 2.5946E-02 1.46E-03 -3.26 -1.23 -4.14E-01
3084 SDF4 232032 x at 2.5954E-02 1.46E-03 -3.26 -1.23 -4.32E-01
3085 CA LG 203538 at 2.5996E-02 1.47E-03 3.26 -1.24 3.88E-01
3086 TOR2A 227972_at 2.6005E-02 1.47E-03 -3.26 -1.24 -2.24E-01
3087 LOC401074 1559827 at 2.6009E-02 1.47E-03 -3.26 -1.24 -1.82E-01
3088 PHC2 200919_at 2.6023E-02 1.47E-03 -3.26 -1.24 -3.41 E-01
3089 229802 at 2.6031 E-02 1.47E-03 -3.26 -1.24 -9.29E-01
3090 NFIB 211467 s at 2.6049E-02 1.47E-03 -3.26 -1.24 -3.71 E-01
3091 C5orf33 226946 at 2.6052E-02 1.47E-03 -3.26 -1.24 -2.70E-01
3092 PERP 217744 s at 2.6054E-02 1.47E-03 -3.26 -1.24 -6.84E-01
3093 BCL2L13 223664 x at 2.6117E-02 1.48E-03 3.26 -1.24 3.71 E-01
3094 PSMA3 237300 at 2.61 17E-02 1.48E-03 3.26 -1.24 2.21E-01
3095 COL3A1 201852 x at 2.6154E-02 1.48E-03 -3.26 -1.24 -1.26E+00
3096 1557667 at 2.6169E-02 1.48E-03 3.26 -1.24 1.91E-01
3097 CD5L 206680 at 2.6169E-02 1.48E-03 -3.26 -1.24 -5.26E-01
3098 DDX21 208152_s_at 2.6213E-02 1.49E-03 -3.26 -1.25 -3.50E-01
3099 CLCN4 231066 s at 2.6213E-02 1.49E-03 3.26 -1.25 1.34E-01
3100 242425 at 2.6213E-02 1.49E-03 3.26 -1.25 2.67E-01
3101 RND3 212724_at 2.6213E-02 1.49E-03 -3.26 -1.25 -4.47E-01
3102 BNIP3 201848 s at 2.6247E-02 1.49E-03 -3.26 -1.25 -4.45E-01
3103 CH P4B 2251 19 at 2.6254E-02 1.49E-03 -3.26 -1.25 -6.04E-01
3104 ZNF7 234920 at 2.6254E-02 1.49E-03 3.26 -1.25 1.06E-01
3105 TCP11 L2 1569207 s at 2.6257E-02 1.49E-03 3.25 -1.25 1.51E-01
3106 242588 at 2.6309E-02 1.49E-03 3.25 -1.25 1.03E-01
3107 STAP1 1554343 a at 2.6325E-02 1.50E-03 3.25 -1.25 7.66E-01
3108 BCR 217223_s_at 2.6325E-02 1.50E-03 -3.25 -1.25 -3.12E-01
3109 229363 at 2.6372E-02 1.50E-03 3.25 -1.25 3.94E-01
3110 227853 at 2.6408E-02 1.50E-03 -3.25 -1.26 -5.65E-01
311 1 ANAPC16 229145 at 2.6432E-02 1.50E-03 3.25 -1.26 4.10E-01
3112 229695 at 2.6432E-02 1.50E-03 3.25 -1.26 3.10E-01
3113 CTNND1 211240 x at 2.6432E-02 1.50E-03 -3.25 -1.26 -3.36E-01
3114 NFIC 206929 s at 2.6470E-02 1.51 E-03 -3.25 -1.26 -3.89E-01
3115 PFDN5 207132 x at 2.6470E-02 1.51 E-03 3.25 -1.26 4.13E-01
3116 ATG12 204833 at 2.6510E-02 1.51 E-03 3.25 -1.26 3.43E-01
3117 242388 x at 2.6520E-02 1.51 E-03 3.25 -1.26 4.31 E-01
311 8 MDM4 205655 at 2.6520E-02 1.51 E-03 3.25 -1.26 2.74E-01
3119 COX5B 213736 at 2.6545E-02 1.51 E-03 3.25 -1.26 4.89E-01
3120 SFXN5 226373 at 2.6564E-02 1.52E-03 -3.25 -1.26 -2.42E-01
3121 FOSL2 228188 at 2.6564E-02 1.52E-03 -3.25 -1.26 -5.82E-01
3122 240314 at 2.6584E-02 1.52E-03 3.25 -1.27 2.89E-01
3123 PPP3CA 202425 x at 2.6585E-02 1.52E-03 -3.25 -1.27 -3.82E-01
3124 NAG 218231 at 2.6585E-02 1.52E-03 -3.25 -1.27 -5.04E-01
3125 SLC24A6 222727 s at 2.6585E-02 1.52E-03 -3.25 -1.27 -2.38E-01
3126 SPRY1 212558 at 2.6585E-02 1.52E-03 -3.25 -1.27 -4.77E-01
3127 ASCL1 209985 s at 2.6594E-02 1.52E-03 3.25 -1.27 1.68E-01
3128 COPZ1 217726 at 2.6603E-02 1.52E-03 -3.25 -1.27 -3.44E-01
3129 CWF19L1 218787 x at 2.6603E-02 1.52E-03 3.25 -1.27 2.07E-01
3130 IMPA1 203011 at 2.6642E-02 1.53E-03 3.25 -1.27 2.84E-01
3131 GABARAP 200645 at 2.6642E-02 1.53E-03 -3.25 -1.27 -3.66E-01
3132 TR1P11 209778 at 2.6642E-02 1.53E-03 -3.25 -1.27 -3.39E-01
3133 PATL1 225468 at 2.6660E-02 1.53E-03 -3.25 -1.27 -5.1 E-01
3134 CENPN 222118 at 2.6673E-02 1.53E-03 3.25 -1.27 4.08E-01
3135 LOC100129 235869_at 2.6692E-02 1.53E-03 3.25 -1.27 1.17E-01 858
3136 MFHAS1 225478 at 2.6713E-02 1.53E-03 -3.25 -1.27 -3.55E-01
3137 S100A16 227998 at 2.6713E-02 1.53E-03 -3.25 -1.27 -4.43E-01
3138 236489 at 2.6715E-02 1.53E-03 3.25 -1.27 1.01E-01
3139 ATP6AP1 207809 s at 2.6715E-02 1.53E-03 -3.25 -1.27 -5.61 E-01
3140 RAX2 155231 1 a at 2.6715E-02 1.53E-03 3.25 -1.28 2.10E-01
3141 243224 at 2.6715E-02 1.53E-03 3.25 -1.28 2.98E-01
3142 LRB1 242628 at 2.6729E-02 1.54E-03 3.25 -1.28 2.22E-01
3143 MT1X 208581 x at 2.6742E-02 1.54E-03 -3.25 -1.28 -7.85E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
3144 TNP2 207736 s at 2.6742E-02 1.54E-03 3,25 -1.28 1.12E-01
3145 PHF23 1555789 s at 2.6742E-02 1.54E-03 -3.25 -1.28 -3.69E-01
3146 RSU1 201980 s at 2.6742E-02 1.54E-03 -3.25 -1.28 -4.80E-01
3147 Z Y 5 206744 s at 2.6773E-02 1.54E-03 3.24 -1.28 1.18E-01
3148 ARPP21 220359 s at 2.6798E-02 1.54E-03 3.24 -1.28 1.19E-01
3149 TYR03P 1566934 at 2.6827E-02 1.55E-03 3.24 -1.28 1.36E-01
3150 CBR1 209213 at 2.6827E-02 1.55E-03 -3.24 -1.28 -4.71 E-01
3151 XPA 232967 at 2.6827E-02 1.55E-03 3.24 -1.28 1.23E-01
3152 NOM03///N 221853_s_at 2.6834E-02 1.55E-03 -3.24 -1.28 -4.01 E-01 OM02///NO
M01
3153 PAFAH1 B2 224777 s at 2.6848E-02 1.55E-03 -3.24 -1.28 -3.61 E-01
3154 241434 at 2.6857E-02 1.55E-03 3.24 -1.28 2.33E-01
3155 FAM120B 227895 at 2.6867E-02 1.55E-03 -3.24 -1.28 -1.70E-01
3156 233431 x at 2.6867E-02 1.55E-03 3.24 -1.28 2.06E-01
3157 MKRN2 222510 s at 2.6867E-02 1.55E-03 -3.24 -1.28 -3.34E-01
3158 LOC645468 216494 at 2.6867E-02 1.55E-03 3.24 -1.29 1.36E-01
3159 RGMA 223468 s at 2.6869E-02 1.55E-03 -3.24 -1.29 -2.81 E-01
3160 FRMD6 225464 at 2.6880E-02 1.55E-03 -3.24 -1.29 -7.17E-01
3161 AK2 205996 s at 2.6902E-02 1.56E-03 -3.24 -1.29 -4.15E-01
3162 TUBB2C 208977_x_at 2.6902E-02 1.56E-03 -3.24 -1.29 -4.47E-01
3163 1561575 at 2.6920E-02 1.56E-03 3.24 -1.29 9.98E-02
3164 UBC///UBB// 242214_at 2.6920E-02 1.56E-03 3.24 -1.29 3.55E-01 /RPS27A
3165 COL28A1 239921 at 2.6920E-02 1.56E-03 3.24 -1.29 9.75E-02
3166 CCDC59 218936 s at 2.6927E-02 1.56E-03 3.24 -1.29 3.90E-01
3167 FANCF 222713 s at 2.6927E-02 1.56E-03 3.24 -1.29 2.61 E-01
3168 RAB5C 201140 s at 2.6928E-02 1.56E-03 -3.24 -1.29 -3.88E-01
3169 LOC254128 235132 at 2.6928E-02 1.56E-03 3.24 -1.29 2.78E-01
3170 OFD1 203569 s at 2.6959E-02 1.56E-03 3.24 -1.29 3.48E-01
3171 PI 3C2A 226094 at 2.6959E-02 1.56E-03 -3.24 -1.29 -4.75E-01
3172 IAA2013 224706 at 2.6974E-02 1.56E-03 -3.24 -1.29 -3.76E-01
3173 236353 at 2.7045E-02 1.57E-03 3.24 -1.30 1.90E-01
3174 244082 at 2.7052E-02 1.57E-03 3.24 -1.30 1.62E-01
3175 238369 s at 2.7052E-02 1.57E-03 3.24 -1.30 1.33E-01
3176 PTPRN2 203030 s at 2.7053E-02 1.57E-03 3.24 -1.30 5.33E-01
3177 SLC7A8 216092 s at 2.7053E-02 1.57E-03 -3.24 -1.30 -3.35E-01
3178 241798 at 2.7074E-02 1.57E-03 3.24 -1.30 3.84E-01
3179 E2F7 241725 at 2.7099E-02 1.58E-03 3.24 -1.30 1.46E-01
3180 FN3 219744 at 2.7099E-02 1.58E-03 3.24 -1.30 1.57E-01
3181 NID1 202008 s at 2.7122E-02 1.58E-03 -3.24 -1.30 -3.80E-01
3182 CD44 229221 at 2.7122E-02 1.58E-03 -3.24 -1.30 -3.36E-01
3183 1557699 x at 2.7122E-02 1.58E-03 3.24 -1.30 1.84E-01
3184 229243 at 2.7122E-02 1.58E-03 3.24 -1.30 2.06E-01
3185 C11orf30 1569349 at 2.7122E-02 1.58E-03 3.24 -1.30 4.91 E-01
3186 BMP1 202701 at 2.7122E-02 1.58E-03 -3.24 -1.30 -3.24E-01
3187 ATP8B5P 1568686 at 2.7125E-02 1.58E-03 3.24 -1.30 8.90E-02
3188 MAP1S 218522 s at 2.7125E-02 1.58E-03 -3.24 -1.30 -4.29E-01
3189 SIKE1 204665 at 2.7125E-02 1.58E-03 3.24 -1.30 1.31 E-01
3190 1562069 at 2.7126E-02 1.58E-03 3.24 -1.30 1.40E-01
3191 LPP 202822 at 2.7148E-02 1.58E-03 -3.24 -1.30 -3.86E-01
3192 COL6A2 209156 s at 2.7150E-02 1.59E-03 -3.24 -1.30 -1.07E+00
3193 TMED5 202195 s at 2.7150E-02 1.59E-03 -3.24 -1.30 -4.03E-01
3194 1564097 at 2.7154E-02 1.59E-03 3.24 -1.30 1.11E-01
3195 ZDHHC21 229240 at 2.7154E-02 1.59E-03 3.24 -1.30 3.13E-01
3196 233331 at 2.7156E-02 1.59E-03 3.24 -1.30 1.93E-01
3197 GKAP1 229312 s at 2.7206E-02 1.59E-03 3.23 -1.31 3.60E-01
3198 ELL3 219518 s at 2.7209E-02 1.59E-03 3.23 -1.31 8.14E-01
3199 THTPA 218540 at 2.7242E-02 1.59E-03 -3.23 -1.31 -2.65E-01
3200 237399 at 2.7256E-02 1.60E-03 3.23 -1.31 1.24E-01
3201 1556984 at 2.7256E-02 1.60E-03 3.23 -1.31 1.63E-01
3202 DYX1 C1 235273 at 2.7256E-02 1.60E-03 3.23 -1.31 1.17E-01
3203 SLC03A1 219229 at 2.7256E-02 1.60E-03 -3.23 -1.31 -5.36E-01
3204 LOC729580 225860 at 2.7311E-02 1.60E-03 -3.23 -1.31 -3.73E-01
3205 HADHB 201007 at 2.7364E-02 1.60E-03 -3.23 -1.31 -2.06E-01
3206 IGF1 209541 at 2.7377E-02 1.61 E-03 -3.23 -1.32 -1.19E+00
3207 UCHL1 201387 s at 2.7377E-02 1.61 E-03 -3.23 -1.32 -6.34E-01
3208 APLP2 208248 x at 2.7408E-02 1.61 E-03 -3.23 -1.32 -4.85E-01
3209 UBE2DNL 1554763 at 2.7421E-02 1.61 E-03 3.23 -1.32 1.43E-01
No. Gene* Probe ID" Adj. p value P value f 8 Log FC
3210 TAS2R19 1570384 at 2.7433E-02 1.61 E-03 3.23 -1.32 9.98E-02
3211 WDR83 224434 s at 2.7455E-02 1.61 E-03 -3.23 -1.32 -2.14E-01
3212 FKBP9 212169 at 2.7459E-02 1.61E-03 -3.23 -1.32 -6.04E-01
3213 PUS7L 229751 s at 2.7459E-02 1.61 E-03 3.23 -1.32 2.83E-01
3214 1555631 at 2.7459E-02 1.61E-03 3.23 -1.32 2.13E-01
3215 SNRPG 205644 s at 2.7459E-02 1.62E-03 3.23 -1.32 4.72E-01
3216 TLR10 223750 s at 2.7459E-02 1.62E-03 3.23 -1.32 6.30E-01
3217 RAD23A 201039 s at 2.7461 E-02 1.62E-03 -3.23 -1.32 -4.75E-01
3218 SDHAP1 222021 x at 2.7498E-02 1.62E-03 -3.23 -1.32 -2.23E-01
3219 PHKB 202738 s at 2.7498E-02 1.62E-03 -3.23 -1.32 -3.65E-01
3220 CBLN4 234024 at 2.7520E-02 1.62E-03 3.23 -1.32 1.38E-01
3221 C0L14A1 212865 s at 2.7520E-02 1.62E-03 -3.23 -1.32 -8.51E-01
3222 1558481 s at 2.7521 E-02 1.62E-03 3.23 -1.32 1.30E-01
3223 IRAKI 1555784 s at 2.7529E-02 1.62E-03 -3.23 -1.32 -2.26E-01
3224 CCDC80 225241 at 2.7539E-02 1.62E-03 -3.23 -1.33 -8.21 E-01
3225 STX4 203530 s at 2.7568E-02 1.63E-03 -3.23 -1.33 -4.24E-01
3226 DUT 208956 x at 2.7568E-02 1.63E-03 3.23 -1.33 2.30E-01
3227 DHX9 202420 s at 2.7578E-02 1.63E-03 -3.23 -1.33 -2.95E-01
3228 C9orf27 1570345 at 2.7593E-02 1.63E-03 3.23 -1.33 1.08E-01
3229 PPIL3 224364 s at 2.7624E-02 1.63E-03 3.23 -1.33 4.80E-01
3230 MYD88 209124 at 2.7624E-02 1.63E-03 -3.23 -1.33 -3.78E-01
3231 1570375 at 2.7639E-02 1.63E-03 -3.23 -1.33 -1.80E-01
3232 PARVA 222454 s at 2.7639E-02 1.63E-03 -3.23 -1.33 -4.58E-01
3233 PL0D2 202619 s at 2.7639E-02 1.63E-03 -3.23 -1.33 -9.42E-01
3234 CRISP2 210262 at 2.7651 E-02 1.64E-03 3.23 -1.33 1.23E-01
3235 FAM178A 235590 at 2.7661 E-02 1.64E-03 3.23 -1.33 2.34E-01
3236 TIMM17A 201821_s_at 2.7670E-02 1.64E-03 -3.23 -1.33 -3.30E-01
3237 FAM114A1 213455 at 2.7670E-02 1.64E-03 -3.23 -1.33 -5.13E-01
3238 ZNF395 232694 at 2.7670E-02 1.64E-03 3.23 -1.33 1.24E-01
3239 U2AF1 231904 at 2.7670E-02 1.64E-03 3.23 -1.33 3.20E-01
3240 1561679 at 2.7670E-02 1.64E-03 3.23 -1.33 1.12E-01
3241 TMEM63A 215583 at 2.7717E-02 1.64E-03 3.22 -1.34 2.13E-01
3242 233784 at 2.7729E-02 1.64E-03 3.22 -1.34 1.23E-01
3243 HDAC8 223345 at 2.7729E-02 1.65E-03 -3.22 -1.34 -1.89E-01
3244 METTL13 206468 s at 2.7729E-02 1.65E-03 -3.22 -1.34 -3.56E-01
3245 ACTB 224594 x at 2.7729E-02 1.65E-03 -3.22 -1.34 -3.81 E-01
3246 PPP3CA 202457 s at 2.7729E-02 1.65E-03 -3.22 -1.34 -4.27E-01
3247 ZNF677 1569039 s at 2.7729E-02 1.65E-03 3.22 -1.34 3.11 E-01
3248 CRTAP 1554464 a at 2.7729E-02 1.65E-03 -3.22 -1.34 -7.39E-01
3249 TUFM 201113 at 2.7749E-02 1.65E-03 -3.22 -1.34 -2.48E-01
3250 GABARAPL 208869_s_at 2.7757E-02 1.65E-03 -3.22 -1.34 -3.27E-01 1
3251 C18orf12 1553087 at 2.7799E-02 1.65E-03 3.22 -1.34 1.47E-01
3252 SFRP2 223122 s at 2.7818E-02 1.65E-03 -3.22 -1.34 -1.83E+00
3253 FAM58A 226466 s at 2.7820E-02 1.66E-03 3.22 -1.34 3.59E-01
3254 TNP03 214550 s at 2.7847E-02 1.66E-03 -3.22 -1.34 -4.72E-01
3255 SLC1A4 209611 s at 2.7882E-02 1.66E-03 3.22 -1.34 1.62E-01
3256 ASIP 214498 at 2.7921 E-02 1.66E-03 3.22 -1.35 1.41 E-01
3257 0SGEPL1 230032 at 2.7930E-02 1.66E-03 3.22 -1.35 3.23E-01
3258 MYLIP 227707 at 2.7942E-02 1.67E-03 3.22 -1.35 1.88E-01
3259 AGPAT3 223183 at 2.7974E-02 1.67E-03 -3.22 -1.35 -4.06E-01
3260 PTGS1 205127 at 2.7980E-02 1.67E-03 -3.22 -1.35 -1.92E-01
3261 TPPP 230197 s at 2.7981 E-02 1.67E-03 3.22 -1.35 1.17E-01
3262 GNAS 217673 x at 2.8013E-02 1.67E-03 -3.22 -1.35 -3.20E-01
3263 BRCC3 231913 s at 2.8017E-02 1.67E-03 -3.22 -1.35 -3.27E-01
3264 BRWD1 231960 at 2.8050E-02 1.68E-03 3.22 -1.35 2.79E-01
3265 CLPTM1 L 223020 at 2.8050E-02 1.68E-03 -3.22 -1.35 -5.36E-01
3266 NCKAP1 L 209734 at 2.8065E-02 1.68E-03 -3.22 -1.35 -4.83E-01
3267 ZNF571 206648 at 2.8065E-02 1.68E-03 3.22 -1.35 3.41 E-01
3268 CCDC23 244013 at 2.8065E-02 1.68E-03 3.22 -1.35 1.39E-01
3269 GART 230097 at 2.8095E-02 1.68E-03 3 22 -1.36 4.36E-01
3270 GDE1 202593 s at 2.8095E-02 1.68E-03 -3.22 -1.36 -7.06E-01
3271 241906 at 2.8095E-02 1.68E-03 3.22 -1.36 2.71 E-01
3272 WDR62 1553123 at 2.8095E-02 1.68E-03 3.22 -1.36 1.74E-01
3273 C2CD2L 204757 s at 2.8127E-02 1.68E-03 -3.22 -1.36 -2.69E-01
3274 ATP6AP2 201444 s at 2.8152E-02 1.69E-03 -3.22 -1.36 -4.47E-01
3275 STK4 223746 at 2.8163E-02 1.69E-03 3.22 -1.36 4.83E-01
3276 CD6 1566448 at 2.8163E-02 1.69E-03 3.22 -1.36 3.20E-01
3277 RPS8 200858 s at 2.8166E-02 1.69E-03 3.22 -1.36 2.21E-01
No. Gene* Probe ID" Adj. p value P value f B Log FC
3278 KCTD5 218474 s at 2.8180E-02 1.69E-03 -3.22 -1.36 -4.31 E-01
3279 MRPL24 218270 at 2.8193E-02 1.69E-03 -3.22 -1.36 -2.19E-01
3280 AIM1 L 220290 at 2.8223E-02 1.69E-03 3.22 -1.36 1.44E-01
3281 PDXDC1 212053 at 2.8232E-02 1.70E-03 -3.21 -1.36 -2.82E-01
3282 ZNF107 243312 at 2.8232E-02 1.70E-03 3.21 -1.36 1.85E-01
3283 MXD1 226275 at 2.8232E-02 1.70E-03 -3.21 -1.36 -4.10E-01
3284 ZNF335 78330 at 2.8232E-02 1.70E-03 3.21 -1.36 1.46E-01
3285 ZC3HAV1L 228280 at 2.8232E-02 1.70E-03 -3.21 -1.36 -3.97E-01
3286 C22orf9 217118 s at 2.8232E-02 1.70E-03 -3.21 -1.36 -4.42E-01
3287 NCRNA000 232910_at 2.8232E-02 1.70E-03 3.21 -1.36 2.43E-01 81
3288 UBE2F 231948 s at 2.8232E-02 1.70E-03 -3.21 -1.36 -3.26E-01
3289 SPTLC2 216202 s at 2.8233E-02 1.70E-03 -3.21 -1.36 -6.58E-01
3290 LEPREL1 230813 at 2.8240E-02 1.70E-03 3.21 -1.37 2.72E-01
3291 ETS2 201329 s at 2.8256E-02 1.70E-03 -3.21 -1.37 -4.40E-01
3292 SLC2A9 219991 at 2.8256E-02 1.70E-03 -3.21 -1.37 -2.81 E-01
3293 BTD 204167 at 2.8256E-02 1.70E-03 -3.21 -1.37 -2.35E-01
3294 1562821 a at 2.8256E-02 1.70E-03 3.21 -1.37 1.24E-01
3295 226348 at 2.8256E-02 1.70E-03 -3.21 -1.37 -2.78E-01
3296 FOX03 204132_s_at 2.8256E-02 1.70E-03 -3.21 -1.37 -4.29E-01
3297 CC O 210021 s at 2.8256E-02 1.70E-03 3.21 -1.37 1.48E-01
3298 235964_x_at 2.8256E-02 1.70E-03 -3.21 -1.37 -3.36E-01
3299 TSTD1 226482 s at 2.8260E-02 1.71 E-03 3.21 -1.37 5.18E-01
3300 POLR1 B 220113 x at 2.8311 E-02 1.71E-03 3.21 -1.37 3.31 E-01
3301 PTGIS 208131 s at 2.8311 E-02 1.71 E-03 -3.21 -1.37 -1.13E+00
3302 PRMT5 1564521 x at 2.8316E-02 1.71 E-03 -3.21 -1.37 -1.80E-01
3303 CLEC4G 1559065 a at 2.8346E-02 1.71 E-03 -3.21 -1.37 -8.54E-01
3304 PARD3B 1553190_s_at 2.8355E-02 1.71 E-03 3.21 -1.37 1.74E-01
3305 LOC338579 1570473 at 2.8355E-02 1.71 E-03 3.21 -1.37 1.01 E-01
3306 PDIA5 203857 s at 2.8370E-02 1.72E-03 -3.21 -1.37 -6.02E-01
3307 UNC13C 1556095 at 2.8370E-02 1.72E-03 3.21 -1.37 1.19E-01
3308 THADA 1566889 at 2.8370E-02 1.72E-03 3.21 -1.37 2.08E-01
3309 DAB2 201278 at 2.8370E-02 1.72E-03 -3.21 -1.37 -5.10E-01
3310 PLEK 203470 s at 2.8370E-02 1.72E-03 -3.21 -1.37 -6.03E-01
3311 Sep-11 201307 at 2.8392E-02 1.72E-03 -3.21 -1.38 -5.03E-01
3312 PRSS47 234696 at 2.8480E-02 1.73E-03 3.21 -1.38 1.45E-01
3313 ARPC2 207988 s at 2.8480E-02 1.73E-03 -3.21 -1.38 -1.76E-01
3314 ZNF587 231820 x at 2.8490E-02 1.73E-03 3.21 -1.38 1.29E-01
3315 SULF2 224724 at 2.8490E-02 1.73E-03 -3.21 -1.38 -6.20E-01
3316 UBQLN2 215884 s at 2.8502E-02 1.73E-03 -3.21 -1.38 -3.15E-01
3317 FKSG43///F 224271_x_at 2.8545E-02 1.73E-03 3.21 -1.38 1.39E-01 RMD8
3318 RPL35A 225190 x at 2.8565E-02 1.73E-03 3.21 -1.38 2.22E-01
3319 FU 12334 232664 at 2.8567E-02 1.73E-03 3.21 -1.38 2.39E-01
3320 PHF11 242060 x at 2.8579E-02 1.74E-03 3.21 -1.38 2.88E-01
3321 LAMC1 200770 s at 2.8579E-02 1.74E-03 -3.21 -1.38 -3.39E-01
3322 SLC2A13 227176 at 2.8579E-02 1.74E-03 -3.21 -1.38 -3.72E-01
3323 MFHAS1 213457 at 2.8579E-02 1.74E-03 -3.21 -1.38 -4.76E-01
3324 I KB KG 36004 at 2.8579E-02 1.74E-03 -3.21 -1.38 -2.08E-01
3325 240016 at 2.8596E-02 1.74E-03 3.21 -1.39 1.89E-01
3326 DPH5 219590 x at 2.8596E-02 1.74E-03 3.21 -1.39 4.39E-01
3327 SGPL1 212321 at 2.8596E-02 1.74E-03 -3.21 -1.39 -5.49E-01
3328 RPL22P22 217363 x at 2.8596E-02 1.74 E-03 3.21 -1.39 1.84E-01
3329 SEC14L1 202082 s at 2.8601 E-02 1.74E-03 -3.21 -1.39 -4.83E-01
3330 ZNF132 207402 at 2.8605E-02 1.74E-03 -3.21 -1.39 -1.21 E-01
3331 HABP4 209818 s at 2.8608E-02 1.74E-03 -3.21 -1.39 -1.45E-01
3332 NPM1 221923 s at 2.8611 E-02 1.74E-03 3.21 -1.39 3.16E-01
3333 216437 at 2.8649E-02 1.75E-03 3.21 -1.39 1.64E-01
3334 DDX46 229098 s at 2.8649E-02 1.75E-03 3.21 -1.39 2.08E-01
3335 CR1 217552 x at 2.8750E-02 1.75E-03 -3.20 -1.39 -3.86E-01
3336 LONP1 209017 s at 2.8757E-02 1.75E-03 -3.20 -1.39 -3.73E-01
3337 PMP22 210139 s at 2.8763E-02 1.76E-03 -3.20 -1.39 -6.26E-01
3338 ZNF585A 227674 at 2.8763E-02 1.76E-03 3.20 -1.39 8.00E-01
3339 ANKRD49 219069 at 2.8763E-02 1.76E-03 3.20 -1.39 3.84E-01
3340 KIAA1462 231841 s at 2.8763E-02 1.76E-03 -3.20 -1.39 -3.18E-01
3341 LOC728868 1559586 at 2.8763E-02 1.76E-03 3.20 -1.39 1.56E-01
3342 KCNG2 208550 x at 2.8766E-02 1.76E-03 3.20 -1.40 1.37E-01
3343 TP53TG1 210886 x at 2.8767E-02 1.76E-03 3.20 -1.40 5.29E-01
3344 LOC650794 243760 at 2.8782E-02 1.76E-03 3.20 -1.40 1.55E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
3345 TMEM164 223202 s at 2.8796E-02 1.76E-03 -3.20 -1.40 -2.78E-01
3346 244599 at 2.8796E-02 1.76E-03 3.20 -1.40 3.66E-01
3347 YME1L1 201351 s at 2.8796E-02 1.76E-03 -3.20 -1.40 -2.94E-01
3348 1564155 x at 2.8796E-02 1.76E-03 3.20 -1.40 3.12E-01
3349 SRPK2 203182 s at 2.8802E-02 1.76E-03 3.20 -1.40 4.60E-01
3350 NCRNA002 1552607_at 2.8818E-02 1.77E-03 3.20 -1.40 1.74E-01 04///NCRNA
00204B
3351 APC 215310 at 2.8832E-02 1.77E-03 3.20 -1.40 2.23E-01
3352 241837 at 2.8832E-02 1.77E-03 3.20 -1.40 6.34E-01
3353 LILRA6 208594 x at 2.8858E-02 1.77E-03 -3.20 -1.40 -3.94E-01
3354 PTCD1 222796 at 2.8858E-02 1.77E-03 3.20 -1.40 1.57E-01
3355 ATP6V1 B2 201089 at 2.8858E-02 1.77E-03 -3.20 -1.40 -4.99E-01
3356 COL1A1 1556499 s at 2.8858E-02 1.77E-03 -3.20 -1.40 -9.21 E-01
3357 C20orf166 232892 at 2.8858E-02 1.77E-03 3.20 -1.40 1.75E-01
3358 CPXM2 226824 at 2.8858E-02 1.77E-03 -3.20 -1.40 -4.62E-01
3359 SLC31A1 235013 at 2.8875E-02 1.77E-03 -3.20 -1.40 -4.99E-01
3360 1563116 at 2.8887E-02 1.78E-03 3.20 -1.40 9.96E-02
3361 KIAA1109 233096 at 2.8902E-02 1.78E-03 3.20 -1.40 1.40E-01
3362 TREML1 1555659 a at 2.8947E-02 1.78E-03 3.20 -1.41 1.99E-01
3363 ING2 205981_s_at 2.8955E-02 1.78E-03 -3.20 -1.41 -3.52E-01
3364 SLC30A7 240277 at 2.8955E-02 1.78E-03 -3.20 -1.41 -2.90E-01
3365 C9orf156 222195 s at 2.8955E-02 1.78E-03 3.20 -1.41 2.34E-01
3366 HYAL2 206855 s at 2.8955E-02 1.78E-03 -3.20 -1.41 -2.72E-01
3367 GIMAP8 235306 at 2.8966E-02 1.78E-03 -3.20 -1.41 -4.62E-01
3368 PISD 202392 s at 2.8966E-02 1.78E-03 -3.20 -1.41 -2.36E-01
3369 WDR64 1553373 at 2.8979E-02 1.79E-03 3.20 -1.41 1.61 E-01
3370 MRC2 37408 at 2.8983E-02 1.79E-03 -3.20 -1.41 -5.49E-01
3371 MFNG 204152 s at 2.8983E-02 1.79E-03 -3.20 -1.41 -3.53E-01
3372 240585 at 2.8983E-02 1.79E-03 3.20 -1.41 9.74E-02
3373 244868 at 2.8986E-02 1.79E-03 3.20 -1.41 2.64E-01
3374 GORASP2 208842 s at 2.8986E-02 1.79E-03 -3.20 -1.41 -3.22E-01
3375 C20orf201 1554977 at 2.8986E-02 1.79E-03 3.20 -1.41 1.84E-01
3376 PAN 2 238856 s at 2.8990E-02 1.79E-03 3.20 -1.41 5.68E-01
3377 DSTN 201021 s at 2.8997E-02 1.79E-03 -3.20 -1.41 -4.06E-01
3378 TP53TG1 210241 s at 2.8997E-02 1.79E-03 3.20 -1.41 5.91 E-01
3379 215968 at 2.9091 E-02 1.80E-03 3.20 -1.41 1.73E-01
3380 BNL2 205018 s at 2.9091 E-02 1.80E-03 -3.20 -1.42 -3.76E-01
3381 SLC12A7 218066 at 2.9125E-02 1.80E-03 -3.20 -1.42 -3.44E-01
3382 MRPS33 218654 s at 2.9147E-02 1.80E-03 3.20 -1.42 4.91 E-01
3383 ABCF1 200045 at 2.9147E-02 1.80E-03 -3.20 -1.42 -4.39E-01
3384 CRYBB2P1 1561274 at 2.9147E-02 1.81 E-03 3.20 -1.42 1.17E-01
3385 PSEN1 207782 s at 2.9147E-02 1.81 E-03 -3.20 -1.42 -5.29E-01
3386 240201 at 2.9147E-02 1.81 E-03 3.19 -1.42 2.06E-01
3387 AGPAT6 224776 at 2.9147E-02 1.81 E-03 -3.19 -1.42 -4.14E-01
3388 SMARCA4 215714 s at 2.9147E-02 1.81 E-03 -3.19 -1.42 -6.01 E-01
3389 C17orf100 229071 at 2.9147E-02 1.81 E-03 3.19 -1.42 1.77E-01
3390 COR07 219040 at 2.9147E-02 1.81 E-03 -3.19 -1.42 -3.04E-01
3391 ANKHD1- 233292_s_at 2.9147E-02 1.81 E-03 -3.19 -1.42 -3.74E-01 EIF4EBP3///
ANKHD1///E
IF4EBP3
3392 DOK1 211121 s at 2.9175E-02 1.81 E-03 -3.19 -1.42 -2.52E-01
3393 BTBD18 215349 at 2.9186E-02 1.81 E-03 3.19 -1.42 2.10E-01
3394 LSM5 202904 s at 2.9200E-02 1.81 E-03 3.19 -1.42 6.93E-01
3395 SSTR1 208482 at 2.9200E-02 1.81 E-03 3.19 -1.42 1.24E-01
3396 PTPRA 213795 s at 2.9213E-02 1.81 E-03 -3.19 -1.42 -3.59E-01
3397 KCN A1 221583 s at 2.9222E-02 1.82E-03 -3.19 -1.42 -6.12E-01
3398 GPBP1 224648 at 2.9247E-02 1.82E-03 3.19 -1.42 2.55E-01
3399 RBM8A 214113 s at 2.9247E-02 1.82E-03 -3.19 -1.42 -4.24E-01
3400 SLC6A16 1569940 at 2.9247E-02 1.82E-03 3.19 -1.43 2.35E-01
3401 SAP30 204900 x at 2.9247E-02 1.82E-03 -3.19 -1.43 -3.97E-01
3402 CDK4 202246 s at 2.9247E-02 1.82E-03 -3.19 -1.43 -3.81 E-01
3403 RRBP1 201203 s at 2.9247E-02 1.82E-03 -3.19 -1.43 -2.57E-01
3404 GUSBP1///G 226947_at 2.9247E-02 1.82E-03 3.19 -1.43 2.82E-01 USBL2
3405 C10orf35 226313 at 2.9250E-02 1.82E-03 3.19 -1.43 2.13E-01
3406 LOC653739 1561894 at 2.9274E-02 1.82E-03 3.19 -1.43 1.60E-01
3407 LRMP 240718 at 2.9274E-02 1.82E-03 3.19 -1.43 1.92E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
3408 C9orf89 223398 at 2.9280E-02 1.83E-03 -3.19 -1.43 -2.86E-01
3409 216628 at 2.9280E-02 1.83E-03 -3.19 -1.43 -1.31E-01
3410 DNAJA1 200880 at 2.9280E-02 1.83E-03 -3.19 -1.43 -3.89E-01
341 1 FAM59A 219377 at 2.9288E-02 1.83E-03 -3.19 -1.43 -1.52E-01
3412 236479 at 2.9288E-02 1.83E-03 3.19 -1.43 1.44E-01
3413 MSRB3 225782 at 2.9288E-02 1.83E-03 -3.19 -1.43 -8.47E-01
3414 243383 at 2.9303E-02 1.83E-03 3.19 -1.43 1.74E-01
3415 LPHN2 206953 s at 2.9317E-02 1.83E-03 -3.19 -1.43 -3.17E-01
3416 C17orf72 232972 at 2.9320E-02 1.83E-03 3.19 -1.43 1.62E-01
3417 PSMD4 210460 s at 2.9332E-02 1.83E-03 -3.19 -1.43 -4.37E-01
3418 236528 at 2.9332E-02 1.83E-03 3.19 -1.43 2.86E-01
3419 1567000 at 2.9332E-02 1.83E-03 3.19 -1.43 9.51 E-02
3420 RGS20 1569303_s_at 2.9340E-02 1.84E-03 3.19 -1.43 1.49E-01
3421 CPPED1 218610 s at 2.9340E-02 1.84E-03 -3.19 -1.43 -3.07E-01
3422 GRIK2 215655 at 2.9340E-02 1.84E-03 3.19 -1.43 8.57E-02
3423 SOAT1 221561 at 2.9340E-02 1.84E-03 -3.19 -1.43 -4.29E-01
3424 CIZ1 205516 x at 2.9377E-02 1.84E-03 -3.19 -1.44 -3.12E-01
3425 PPP1 R7 213465 s at 2.9377E-02 1.84E-03 -3.19 -1.44 -4.71 E-01
3426 241928 at 2.941 OE-02 1.84E-03 3.19 -1.44 1.90E-01
3427 TIMM9 218316 at 2.9430E-02 1.84E-03 3.19 -1.44 4.14E-01
3428 MLH1 202520 s at 2.9430E-02 1.85E-03 -3.19 -1.44 -2.72E-01
3429 XP07 212166 at 2.9431 E-02 1.85E-03 -3.19 -1.44 -3.93E-01
3430 PPP1 R1 1 1566303 s at 2.9431 E-02 1.85E-03 -3.19 -1.44 -6.58E-01
3431 ADD1 214736 s at 2.9431 E-02 1.85E-03 -3.19 -1.44 -5.26E-01
3432 244125 at 2.9431 E-02 1.85E-03 3.19 -1.44 3.12E-01
3433 ARHGEF11 202914 s at 2.9431 E-02 1.85E-03 -3.19 -1.44 -1.59E-01
3434 C9orf85 238912 x at 2.9456E-02 1.85E-03 3.19 -1.44 4.83E-01
3435 OCM///OCM 207944_at 2.9456E-02 1.85E-03 3.19 -1.44 1.26E-01 2
3436 ERGIC1 224576 at 2.9465E-02 1.85E-03 -3.19 -1.44 -3.72E-01
3437 MCHR1 230498 at 2.9465E-02 1.85E-03 -3.19 -1.44 -3.14E-01
3438 MPP7 238451 at 2.9465E-02 1.85E-03 3.19 -1.44 1.46E-01
3439 F8A3///F8A2 203274_at 2.9479E-02 1.85E-03 -3.19 -1.44 -5.70E-01 ///F8A1
3440 PGCP 208454 s at 2.9509E-02 1.86E-03 -3.19 -1.44 -2.89E-01
3441 TTLL4 203702 s at 2.9553E-02 1.86E-03 -3.19 -1.44 -2.56E-01
3442 WAS 38964 r at 2.9583E-02 1.86E-03 -3.19 -1.45 -3.23E-01
3443 C6orf204 228007 at 2.9583E-02 1.86E-03 3.19 -1.45 3.87E-01
3444 SULT1A2 207122 x at 2.9583E-02 1.86E-03 -3.19 -1.45 -2.52E-01
3445 CELA3A 211738 x at 2.9583E-02 1.86E-03 3.19 -1.45 1.79E-01
3446 CCL13 206407 s at 2.9593E-02 1.87E-03 -3.18 -1.45 -1.45E+00
3447 CCDC88A 219387 at 2.9593E-02 1.87E-03 -3.18 -1.45 -4.74E-01
3448 239238 at 2.9593E-02 1.87E-03 3.18 -1.45 3.57E-01
3449 SCTR 1565738 at 2.9593E-02 1.87E-03 3.18 -1.45 1.54E-01
3450 ZNF302 228392 at 2.9593E-02 1.87E-03 3.18 -1.45 3.29E-01
3451 GATSL3 233528 s at 2.9631 E-02 1.87E-03 -3.18 -1.45 -1.86E-01
3452 LOC100129 244079_at 2.9636E-02 1.87E-03 3.18 -1.45 1.14E-01 335
3453 HEBP1 218450 at 2.9636E-02 1.87E-03 -3.18 -1.45 -3.87E-01
3454 LOC400464 243957 at 2.9636E-02 1.87E-03 3.18 -1.45 3.88E-01
3455 C10orf99 227735 s at 2.9636E-02 1.87E-03 3.18 -1.45 1.90E-01
3456 RGS5 230678 at 2.9650E-02 1.87E-03 3.18 -1.45 1.60E-01
3457 1557897 at 2.9650E-02 1.88E-03 -3.18 -1.45 -1.53E-01
3458 CATSPERB 220293 at 2.9650E-02 1.88E-03 3.18 -1.45 1.42E-01
3459 TP53BP2 203120 at 2.9653E-02 1.88E-03 -3.18 -1.45 -3.04E-01
3460 DNAJC19 225359 at 2.9660E-02 1.88E-03 3.18 -1.45 5.53E-01
3461 KIAA1598 221802 s at 2.9720E-02 1.88E-03 -3.18 -1.45 -5.01 E-01
3462 C6orf47 204968 at 2.9720E-02 1.88E-03 -3.18 -1.45 -2.52E-01
3463 LAPTM4A 200673 at 2.9726E-02 1.88E-03 -3.18 -1.46 -2.63E-01
3464 236485 at 2.9758E-02 1.89E-03 3.18 -1.46 2.28E-01
3465 FAM120A 1555948 s at 2.9782E-02 1.89E-03 -3.18 -1.46 -4.63E-01
3466 GNAI2 201040 at 2.9802E-02 1.89E-03 -3.18 -1.46 -5.65E-01
3467 NBPF10///N 215434_x_at 2.9808E-02 1.89E-03 -3.18 -1.46 -4.38E-01
BPF16///NB
PF24///NBP
F8///AE01///
NBPF9///NB
PF11///KIAA
1245///NBPF
1///NBPF14 ciu
No. Gene* Probe ID** Adj. p value P value t e Log FC
3468 SCYL2 221220 s at 2.9854E-02 1.89E-03 -3.18 -1.46 -5.01 E-01
3469 CNPY3 1552977 a at 2.9868E-02 1.90E-03 -3.18 -1.46 -5.10E-01
3470 TNFAIP1 201208 s at 2.9875E-02 1.90E-03 -3.18 -1.46 -1.71 E-01
3471 EIF3H 201592 at 2.9875E-02 1.90E-03 3.18 -1.46 2.39E-01
3472 SPANXC 220217 x at 2.9875E-02 1.90E-03 3.18 -1.46 1.46E-01
3473 ERGIC1 224577 at 2.9918E-02 1.90E-03 -3.18 -1.46 -4.32E-01
3474 RPS17P5 216348 at 2.9953E-02 1.90E-03 3.18 -1.46 5.04E-01
3475 LACTB 226354 at 2.9964E-02 1.90E-03 -3.18 -1.47 -3.45E-01
3476 JAG2 32137 at 2.9969E-02 1.91 E-03 -3.18 -1.47 -2.53E-01
3477 TO 22 217960 s at 2.9969E-02 1.91 E-03 3.18 -1.47 3.93E-01
3478 ZNF827 228046 at 2.9969E-02 1.91 E-03 3.18 -1.47 3.99E-01
3479 KIAA1715 229173 at 2.9969E-02 1.91 E-03 -3.18 -1.47 -2.38E-01
3480 PP7 1564308 a at 2.9969E-02 1.91 E-03 3.18 -1.47 1.56E-01
3481 APITD1///C 213454_at 2.9969E-02 1.91 E-03 3.18 -1.47 5.16E-01 ORT
3482 PI CALM 212511 at 2.9969E-02 1.91 E-03 -3.18 -1.47 -4.35E-01
3483 NFIC 226895 at 2.9969E-02 1.91 E-03 -3.18 -1.47 -7.42E-01
3484 241728 at 2.9969E-02 1.91 E-03 3.18 -1.47 1.46E-01
3485 SEC23A 204344 s at 2.9969E-02 1.91 E-03 -3.18 -1.47 -2.46E-01
3486 C1orf216 212791 at 2.9969E-02 1.91 E-03 -3.18 -1.47 -3.26E-01
3487 HORMAD2 237781 at 2.9969E-02 1.91 E-03 3.18 -1.47 1.10E-01
3488 CMAH 1554862 at 2.9969E-02 1.91 E-03 3.18 -1.47 1.17E-01
3489 242833 at 2.9969E-02 1.91 E-03 3.18 -1.47 1.26E-01
3490 KCTD20 214849 at 2.9969E-02 1.91 E-03 -3.18 -1.47 -2.97E-01
3491 NACA 200735 x at 2.9998E-02 1.92E-03 3.18 -1.47 2.00E-01
3492 LRP10 201412 at 3.0015E-02 1.92E-03 -3.18 -1.47 -4.19E-01
3493 HIST1 H1 E 208553 at 3.0015E-02 1.92E-03 3.18 -1.47 5.05E-01
3494 KIAA1 04 229891 x at 3.0065E-02 1.92 E-03 3.18 -1.47 2.80E-01
3495 RNASEH2B 229210 at 3.0078E-02 1.92E-03 3.18 -1.47 3.00E-01
3496 ZNF414 227071 at 3.0078E-02 1.92E-03 3.18 -1.47 1.17E-01
3497 MLLT1 224993 at 3.0131E-02 1.93E-03 -3.17 -1.48 -3.35E-01
3498 C3orf78 229826 at 3.0170E-02 1.93E-03 3.17 -1.48 5.05E-01
3499 C3orf21 226891 at 3.0170E-02 1.93E-03 -3.17 -1.48 -2.89E-01
3500 241777 x at 3.0170E-02 1.93E-03 3.17 -1.48 1.55E-01
3501 UQCC 222470 s at 3.0189E-02 1.93E-03 -3.17 -1.48 -1.85E-01
3502 RPL23AP32 207283 at 3.0189E-02 1.93E-03 3.17 -1.48 3.28E-01
3503 SDC2 212157 at 3.0199E-02 1.94E-03 -3.17 -1.48 -2.53E-01
3504 230054 at 3.0199E-02 1.94E-03 3.17 -1.48 1.88E-01
3505 ZNF321 1558888 x at 3.0202E-02 1.94E-03 3.17 -1.48 1.66E-01
3506 HLA-DQB1 211654 x at 3.0202E-02 1.94E-03 -3.17 -1.48 -6.64E-01
3507 RGPD2///R 242712_x_at 3.0206E-02 1.94E-03 3.17 -1.48 2.92E-01
GPD6///RGP
D8///RGPD3
///RGPD1///
RGPD4///R
GPD5///RAN
BP2
3508 TMTC1 224397 s at 3.0206E-02 1.94E-03 -3.17 -1.48 -2.16E-01
3509 KCTD12 212188 at 3.0206E-02 1.94E-03 -3.17 -1.48 -4.37E-01
3510 ZDHHC4 230905 at 3.0207E-02 1.94E-03 3.17 -1.48 1.72E-01
3511 FAM13A 202973 x at 3.0215E-02 1.94E-03 -3.17 -1.48 -5.11 E-01
3512 229004 at 3.0221 E-02 1.94E-03 -3.17 -1.48 -2.69E-01
3513 SLC1A3 202800 at 3.0253E-02 1.94E-03 -3.17 -1.48 -5.86E-01
3514 CMKLR1 207652 s at 3.0288E-02 1.95E-03 -3.17 -1.48 -4.35E-01
3515 RNPEP 208270 s at 3.0288E-02 1.95E-03 -3.1 -1.48 -4.05E-01
3516 RBM34 214942 at 3.0289E-02 1.95E-03 3.17 -1.49 1.70E-01
3517 ULK1 209333 at 3.0289E-02 1.95E-03 -3.17 -1.49 -2.20E-01
3518 240254 at 3.0289E-02 1.95E-03 3.17 -1.49 1.56E-01
3519 ZNF418 243439 at 3.0289E-02 1.95 E-03 3.17 -1.49 2.03E-01
3520 ADORA3 206171 at 3.0289E-02 1.95E-03 -3.17 -1.49 -3.55E-01
3521 HIST1H2BB 208547 at 3.0289E-02 1.95E-03 3.17 -1.49 3.39E-01
3522 INPP5A 203006 at 3.0289E-02 1.95E-03 -3.17 -1.49 -3.00E-01
3523 CD82 203904 x at 3.0289E-02 1.95E-03 -3.17 -1.49 -2.97E-01
3524 NDEL1 208093 s at 3.0289E-02 1.95E-03 -3.17 -1.49 -2.48E-01
3525 ALG14 228871 at 3.0336E-02 1.96E-03 3.17 -1.49 1.76E-01
3526 IQCE 204202 at 3.0348E-02 1.96E-03 -3.17 -1.49 -2.76E-01
3527 AP2A1 234068 s at 3.0349E-02 1.96E-03 -3.17 -1.49 -1.97E-01
3528 SNX9 223028 s at 3.0386E-02 1.96E-03 -3.17 -1.49 -4.02E-01
3529 MAP2K6 205698 s at 3.0389E-02 1.96E-03 3.17 -1.49 3.30E-01
3530 TM4SF1 209387 s at 3.0390E-02 1.96E-03 -3.17 -1.49 -3.82E-01
No. Gene* Probe ID" Adj. p value P value f B Log FC
3531 HNF4A 214832 at 3.0390E-02 1.96E-03 3.17 -1.49 1.57E-01
3532 MKNK1 1560720 at 3.0408E-02 1.96E-03 3.17 -1.49 1.76E-01
3533 TNIP1 243423 at 3.0416E-02 1.97E-03 3.17 -1.49 2.50E-01
3534 SNX24 218705 s at 3.0416E-02 1.97E-03 -3.17 -1.49 -3.44E-01
3535 TUBD1 231853 at 3.0416E-02 1.97E-03 3.17 -1.49 4.50E-01
3536 C21orf91 226109 at 3.0449E-02 1.97E-03 3.17 -1.49 3.03E-01
3537 TMEM30A 217743 s at 3.0451 E-02 1.97E-03 -3.17 -1.50 -3.80E-01
3538 MRPS31 212603 at 3.0462E-02 1.97E-03 3.17 -1.50 2.23E-01
3539 TLN2 232625 at 3.0492E-02 1.97E-03 3.17 -1.50 1.51E-01
3540 240595 at 3.0492E-02 1.97E-03 3.17 -1.50 2.18E-01
3541 ZNF614 227045 at 3.0492E-02 1.97E-03 3.17 -1.50 5.53E-01
3542 SOX17 219993 at 3.0492E-02 1.98E-03 -3.17 -1.50 -2.27E-01
3543 PDE1C 243564 at 3.0506E-02 1.98E-03 3.17 -1.50 1.29E-01
3544 MEGF8 227327 at 3.0553E-02 1.98E-03 -3.17 -1.50 -2.51E-01
3545 RHOA 200059 s at 3.0564E-02 1.98E-03 -3.17 -1.50 -3.63E-01
3546 COL18A1 209082 s at 3.0564E-02 1.98E-03 -3.17 -1.50 -5.32E-01
3547 CALR 212952 at 3.0564E-02 1.98E-03 -3.17 -1.50 -2.12E-01
3548 FBN1 202765 s at 3.0599E-02 1.99E-03 -3.17 -1.50 -6.57E-01
3549 ZNF439 236562 at 3.061 OE-02 1.99E-03 3.16 -1.50 4.05E-01
3550 ME2 210153 s at 3.0636E-02 1.99E-03 -3.16 -1.50 -3.74E-01
3551 TMSB15B/// 214051_at 3.0671 E-02 1.99E-03 3.16 -1.51 6.51E-01 TMSB15A
3552 COL18A1 209081 s at 3.0748E-02 2.00E-03 -3.16 -1.51 -5.69E-01
3553 PHACTR1 213638 at 3.0762E-02 2.00E-03 3.16 -1.51 4.15E-01
3554 JAG2 209784_s at 3.0795E-02 2.00E-03 -3.16 -1.51 -2.71 E-01
3555 SLC12A4 228644 s at 3.0795E-02 2.00E-03 3.16 -1.51 1.67E-01
3556 ZNF598 232367_x at 3.0881 E-02 2.01 E-03 3.16 -1.51 2.32E-01
3557 GAPDH 213453_x_at 3.0881 E-02 2.01 E-03 -3.16 -1.51 -4.29E-01
3558 C11orf31 1557801 _x_at 3.0913E-02 2.01 E-03 3.16 -1.51 2.95E-01
3559 I PA2 203126 at 3.0913E-02 2.01 E-03 -3.16 -1.51 -3.92E-01
3560 GDI1 201864 at 3.0913E-02 2.01 E-03 -3.16 -1.51 -3.49E-01
3561 1568807 a at 3.0966E-02 2.02E-03 3.16 -1.52 2.38E-01
3562 OAT 201599 at 3.0973E-02 2.02E-03 -3.16 -1.52 -3.39E-01
3563 TPM3 238065 at 3.0973E-02 2.02E-03 -3.16 -1.52 -1.72E-01
3564 RPS6 201254 x at 3.1000E-02 2.02E-03 3.16 -1.52 1.60E-01
3565 PAK2 1559052 s at 3.1026E-02 2.02E-03 -3.16 -1.52 -4.38E-01
3566 VPS53 235882 at 3.1037E-02 2.02E-03 -3.16 -1.52 -1.67E-01
3567 211691 x at 3.1037E-02 2.02E-03 3.16 -1.52 2.01E-01
3568 235530 at 3.1049E-02 2.03E-03 3.16 -1.52 2.03E-01
3569 232723 at 3.1050E-02 2.03E-03 3.16 -1.52 1.54E-01
3570 235930 at 3.1053E-02 2.03E-03 3.16 -1.52 1.49E-01
3571 MGC42157 1552987 a at 3.1081 E-02 2.03E-03 3.16 -1.52 1.13E-01
3572 KIAA0895L// 1558041_a_at 3.1113E-02 2.03E-03 -3.16 -1.52 -1.63E-01 /EXOC3L
3573 ZNF654 219239 s at 3.1 116E-02 2.03E-03 -3.16 -1.52 -3.90E-01
3574 ISOC1 218170 at 3.1 116E-02 2.03E-03 -3.16 -1.52 -4.11 E-01
3575 AK2 208967 s at 3.1116E-02 2.03E-03 -3.16 -1.52 -3.37E-01
3576 SMTN 207390 s at 3.1 120E-02 2.04E-03 -3.16 -1.52 -3.19E-01
3577 FKBP5 224840 at 3.1 143E-02 2.04E-03 -3.16 -1.52 -4.72E-01
3578 ACAD10 219986 s at 3.1 143E-02 2.04E-03 3.16 -1.53 2.24E-01
3579 FLJ27354 231313 at 3.1146E-02 2.04E-03 3.16 -1.53 1.77E-01
3580 233275 at 3.1 146E-02 2.04E-03 3.16 -1.53 1.59E-01
3581 LDOC1 L 223228 at 3.1154E-02 2.04E-03 -3.16 -1.53 -3.27E-01
3582 FSD2 237222 at 3.1166E-02 2.04E-03 3.16 -1.53 1.42E-01
3583 MFSD5 212861 at 3.1166E-02 2.04E-03 -3.16 -1.53 -3.98E-01
3584 KIF1 B 225878 at 3.1186E-02 2.04E-03 -3.16 -1.53 -3.36E-01
3585 238298 at 3.1186E-02 2.04E-03 3.16 -1.53 1.13E-01
3586 USP42 226172 at 3.1227E-02 2.05E-03 3.16 -1.53 1.34E-01
3587 C2orf53 237319 at 3.1267E-02 2.05E-03 3.15 -1.53 1.61 E-01
3588 GRM5 1565389 s at 3.1303E-02 2.05E-03 3.15 -1.53 3.03E-01
3589 C15orf29 222745 s at 3.1317E-02 2.06E-03 3.15 -1.53 4.1 1 E-01
3590 BACH2 236796 at 3.1321 E-02 2.06E-03 3.15 -1.53 6.56E-01
3591 IDI1 242065 x at 3.1321 E-02 2.06 E-03 3.15 -1.53 2.06E-01
3592 KIAA1107 1558293 at 3.1347E-02 2.06E-03 3.15 -1.53 1.20E-01
3593 NRD1 229422 at 3.1347E-02 2.06E-03 3.15 -1.54 3.61 E-01
3594 UPF1 211168 s at 3.1347E-02 2.06E-03 -3.15 -1.54 -3.28E-01
3595 239646 at 3.1347E-02 2.06E-03 3.15 -1.54 3.53E-01
3596 PLB1 235703 at 3.1347E-02 2.06E-03 -3.15 -1 .54 -1.42E-01
3597 229444 at 3.1347E-02 2.06E-03 3.15 -1.54 5.47E-01
No. Gene* Probe ID** Adj. p value P value t S Log FC
3598 NFE2L2 1567014 s at 3.1347E-02 2.06E-03 -3.15 -1.54 -2.68E-01
3599 PGK1 200737 at 3.1375E-02 2.07E-03 -3.15 -1.54 -4.69E-01
3600 RAB35 225620 at 3.1376E-02 2.07E-03 -3.15 -1.54 -3.85E-01
3601 230314 at 3.1412E-02 2.07E-03 3.15 -1.54 4.41 E-01
3602 ARHGAP18 225173 at 3.1413E-02 2.07E-03 -3.15 -1.54 -4.44E-01
3603 C19orf26 1552354 at 3.1427E-02 2.07E-03 3.15 -1.54 2.73E-01
3604 SLC7A8 202752 x at 3.1427E-02 2.07E-03 -3.15 -1.54 -2.91 E-01
3605 233729 at 3.1432E-02 2.07E-03 3.15 -1.54 1.62E-01
3606 243558 at 3.1432E-02 2.07E-03 3.15 -1.54 1.24E-01
3607 UBE2H 222419 x at 3.1432E-02 2.07E-03 3.15 -1.54 1.83E-01
3608 C5orf28 219029 at 3.1432E-02 2.07E-03 3.15 -1.54 4.80E-01
3609 SNHG5 225155 at 3.1440E-02 2.08E-03 3.15 -1.54 6.33E-01
3610 ABAT 209460 at 3.1440E-02 2.08E-03 3.15 -1.54 2.39 E-01
3611 MMRN2 219091 s at 3.1482E-02 2.08E-03 -3.15 -1.54 -3.92E-01
3612 FARP1 201911 s at 3.1482E-02 2.08E-03 -3.15 -1.54 -3.56E-01
3613 DSC2 204750 s at 3.1482E-02 2.08E-03 -3.15 -1.54 -5.19E-01
3614 A1BG 229819 at 3.1482E-02 2.08E-03 3.15 -1.54 4.44E-01
3615 C3 217767 at 3.1484E-02 2.08E-03 -3.15 -1.54 -5.92E-01
3616 EXOC7 212035 s at 3.1485E-02 2.08E-03 -3.15 -1.54 -2.48E-01
3617 PER2 205251 at 3.1489E-02 2.08E-03 -3.15 -1.54 -3.11 E-01
3618 TSPAN3 200973_s_at 3.1489E-02 2.08E-03 -3.15 -1.54 -5.29E-01
3619 HLA-A 215313_x_at 3.1501 E-02 2.09E-03 -3.15 -1.55 -3.12E-01
3620 RTN3 224564_s_at 3.1501 E-02 2.09E-03 -3.15 -1.55 -3.74E-01
3621 KDELR1 200922 at 3.1501 E-02 2.09E-03 -3.15 -1.55 -5.90E-01
3622 SCARB1 201819 at 3.1553E-02 2.09E-03 -3.15 -1.55 -4.39E-01
3623 ATP6V0A2 1555114 at 3.1592E-02 2.09E-03 3.15 -1.55 1.53E-01
3624 HGS 232460 at 3.1592E-02 2.09E-03 3.15 -1.55 1.57E-01
3625 C17orf58 226901 at 3.1592 E-02 2.09E-03 -3.15 -1.55 -5.31 E-01
3626 PSMG1 203405 at 3.1592E-02 2.10E-03 -3.15 -1.55 -3.83E-01
3627 242695 at 3.1634E-02 2.10E-03 3.15 -1.55 3.87E-01
3628 PR T2 228725 x at 3.1634E-02 2.10E-03 -3.15 -1.55 -5.69E-01
3629 LOC283435 1561536 at 3.1642E-02 2.10E-03 3.15 -1.55 1.21 E-01
3630 ZFAND6 239757 at 3.1645E-02 2.10E-03 3.15 -1.55 5.12E-01
3631 231139 at 3.1645E-02 2.10E-03 3.15 -1.55 1.23E-01
3632 LOC440934 230844 at 3.1645 E-02 2.10E-03 3.15 -1.55 1.34 E-01
3633 PPP1 R14B 212680 x at 3.1646E-02 2.10E-03 -3.15 -1.55 -3.26E-01
3634 ENC1 201341 at 3.1646E-02 2.10E-03 -3.15 -1.55 -4.50E-01
3635 PTPN2 241983 at 3.1649E-02 2.10E-03 3.15 -1.55 1.74E-01
3636 PSMC5 209503 s at 3.1651 E-02 2.10E-03 -3.15 -1.55 -3.18E-01
3637 GNG7 206896 s at 3.1678E-02 2.11 E-03 3.15 -1.55 3.54E-01
3638 UBE2R2 223014 at 3.1695 E-02 2.11 E-03 -3.15 -1.56 -3.76E-01
3639 239393 at 3.1702E-02 2.11 E-03 3.15 -1.56 3.83E-01
3640 ALS2 232184 at 3.1716E-02 2.11 E-03 3.15 -1.56 1.58E-01
3641 ITPR1 211323 s at 3.1716E-02 2.11 E-03 3.15 -1.56 3.30E-01
3642 241770 x at 3.1716E-02 2.11 E-03 3.15 -1.56 1.27E-01
3643 LOC284801 225762 x at 3.1716E-02 2.11 E-03 3.15 -1.56 3.76E-01
3644 CWC15 223067 at 3.1766 E-02 2.12E-03 3.14 -1.56 3.04E-01
3645 SETD3 229940 at 3.1766E-02 2.12E-03 -3.14 -1.56 -2.04E-01
3646 234731 at 3.1766E-02 2.12E-03 3.14 -1.56 1.96E-01
3647 LOC100288 , 234852_at 3.1766E-02 2.12E-03 3.14 -1.56 2.05E-01
702///ACTR
3P1///RPL4
P1///TRA@//
/SALL2
3648 GAPDH 212581 x at 3.1766E-02 2.12E-03 -3.14 -1.56 -4.04E-01
3649 TNIP2 48531 at 3.1766E-02 2.12E-03 -3.14 -1.56 -3.22E-01
3650 C20orf26 1554657 a at 3.1766E-02 2.12E-03 3.14 -1.56 1.41 E-01
3651 PET112L 204300 at 3.1766E-02 2.12E-03 -3.14 -1.56 -2.29E-01
3652 ATAD2 228401 at 3.1766E-02 2.12E-03 3.14 -1.56 3.14E-01
3653 213549 at 3.1766E-02 2.12E-03 -3.14 -1.56 -3.36E-01
3654 216065 at 3.1766 E-02 2.12E-03 3.14 -1.56 1.35E-01
3655 GDF15 229868 s at 3.1766E-02 2.12E-03 3.14 -1.56 1.15E-01
3656 DMD 207660 at 3.1782 E-02 2.13E-03 3.14 -1.56 1.46E-01
3657 GTF3C4 243228 at 3.1784 E-02 2.13E-03 3.14 -1.56 1.28E-01
3658 EPR1 1555826 at 3.1830 E-02 2.13E-03 3.14 -1.56 3.99E-01
3659 PITPNA 201192 s at 3.1852E-02 2.13E-03 -3.14 -1.56 -3.63E-01
3660 RNF135 223592 s at 3.1852 E-02 2.13E-03 -3.14 -1.56 -4.33E-01
3661 RPL13A 200715 x at 3.1852E-02 2.13E-03 3.14 -1.57 2.05E-01
3662 GBX1 217011 at 3.1865E-02 2.13E-03 3.14 -1.57 2.08E-01
33
No. Gene* Probe ID** Adj. p value P value f B Log FC
3663 239679 at 3.1888E-02 2.14E-03 3.14 -1.57 3.28E-01
3664 HEATR5B 233642 s at 3.1896E-02 2.14E-03 3.14 -1.57 2.97E-01
3665 C12orf76 229679 at 3.1897E-02 2.14E-03 3.14 -1.57 6.12E-01
3666 S TN 1556030 at 3.1933E-02 2.14E-03 3.14 -1.57 1.55E-01
3667 ITGB5 201125 s at 3.1950E-02 2.14E-03 -3.14 -1.57 -6.80E-01
3668 CYBB 203922 s at 3.1957E-02 2.14E-03 -3.14 -1.57 -6.09E-01
3669 DCUN1 D4 212853 at 3.2007E-02 2.15E-03 3.14 -1.57 1.65E-01
3670 BRE 211566 x at 3.2014E-02 2.15E-03 -3.14 -1.57 -2.49E-01
3671 DHX36 1559039 at 3.2049E-02 2.15E-03 3.14 -1.57 2.04E-01
3672 TMEM114 231462 at 3.2049E-02 2.15E-03 3.14 -1.57 1.45E-01
3673 RAPGEF6 2191 12 at 3.2074E-02 2.15E-03 3.14 -1.57 3.57E-01
3674 ZNF704 1558941 at 3.2147E-02 2.16E-03 3.14 -1.58 1.26E-01
3675 MT1P2///MT 216336_x_at 3.2161 E-02 2.16E-03 -3.14 -1.58 -6.46E-01 1 M///MT1H//
/MT1 E
3676 VDR 204255 s at 3.2167E-02 2.16E-03 -3.14 -1.58 -7.43E-01
3677 FERMT2 214212 x at 3.2167E-02 2.16E-03 -3.14 -1.58 -3.64E-01
3678 SORD 201563 at 3.2167E-02 2.16E-03 -3.14 -1.58 -5.96E-01
3679 ADH1 B 209614_at 3.2167E-02 2.16E-03 -3.14 -1.58 -2.57E-01
3680 PDLIM5 203243 s at 3.2167E-02 2.17E-03 -3.14 -1.58 -5.61 E-01
3681 237329_at 3.2167E-02 2.17E-03 3.14 -1.58 1.10E-01
3682 CDKL1 235512 at 3.2167E-02 2.17E-03 3.14 -1.58 2.59E-01
3683 C5orf34 229886 at 3.2167E-02 2.17E-03 3.14 -1.58 2.36E-01
3684 PIGL 232262 at 3.2167E-02 2.17E-03 3.14 -1.58 2.17E-01
3685 LOC283688 1566526 at 3.2248E-02 2.17E-03 3.14 -1.58 1.49E-01
3686 DNAJC30 239018 at 3.2334E-02 2.18E-03 3.14 -1.58 2.21 E-01
3687 ENC1 201340 s at 3.2334E-02 2.18E-03 -3.14 -1.58 -5.17E-01
3688 LRRN4CL 1556427 s at 3.2334E-02 2.18E-03 -3.14 -1.58 -3.02E-01
3689 GOPC 227214 at 3.2350E-02 2.18E-03 -3.14 -1.59 -2.06E-01
3690 C1orf68 217087 at 3.2388E-02 2.19E-03 3.13 -1.59 2.05E-01
3691 THOC7 229525 at 3.2389E-02 2.19E-03 3.13 -1.59 4.19E-01
3692 VWA5A 210102 at 3.2400E-02 2.19E-03 -3.13 -1.59 -3.35E-01
3693 ENPP2 210839 s at 3.2401 E-02 2.19E-03 -3.13 -1.59 -5.97E-01
3694 ZNF638 213775 x at 3.2406E-02 2.19E-03 -3.13 -1.59 -3.88E-01
3695 PPP2R2A 236492 at 3.2406E-02 2.19E-03 3.13 -1.59 3.43E-01
3696 C6orf136 227455 at 3.2426E-02 2.19E-03 -3.13 -1.59 -4.08E-01
3697 ZYX 200808 s at 3.2426E-02 2.19E-03 -3.13 -1.59 -7.32E-01
3698 FICD 219910 at 3.2437E-02 2.19E-03 -3.13 -1.59 -2.66E-01
3699 YKT6 217785 s at 3.2467E-02 2.20E-03 -3.13 -1.59 -3.10E-01
3700 TUSC3 232770 at 3.2482E-02 2.20E-03 3.13 -1.59 1.32E-01
3701 242717 at 3.2482E-02 2.20E-03 3.13 -1.59 1.34E-01
3702 CALD1 201615 x at 3.2482E-02 2.20E-03 -3.13 -1.59 -5.88 E-01
3703 CD48 204118 at 3.2482E-02 2.20E-03 3.13 -1.59 4.95E-01
3704 RICTOR 226310 at 3.2482E-02 2.20E-03 3.13 -1.59 3.45E-01
3705 LYN 210754 s at 3.2497E-02 2.20E-03 -3.13 -1.59 -6.49E-01
3706 USP15 209475 at 3.2505E-02 2.20E-03 3.13 -1.59 3.12E-01
3707 HSD3B7 222817 at 3.2520E-02 2.20E-03 -3.13 -1.59 -3.84E-01
3708 IL2RA 206341 at 3.2536E-02 2.21 E-03 -3.13 -1.59 -5.30E-01
3709 ATP5S 1554177 a at 3.2543E-02 2.21 E-03 3.13 -1.60 2.64E-01
3710 TIMM10 1555764 s at 3.2568E-02 2.21 E-03 3.13 -1.60 4.70E-01
371 1 SFT2D3 226639 at 3.2612E-02 2.21 E-03 3.13 -1.60 1.78E-01
3712 LOC284600 1559083 x at 3.2612E-02 2.21 E-03 3.13 -1.60 1.78E-01
3713 EPHB2 210651 s at 3.2612E-02 2.22E-03 -3.13 -1.60 -1.39E-01
3714 TUSC1 227388 at 3.2612E-02 2.22E-03 -3.13 -1.60 -4.06E-01
3715 INPP5B 213804 at 3.2668E-02 2.22E-03 3.13 -1.60 2.13E-01
3716 CTBP2 201220 x at 3.2791 E-02 2.23E-03 -3.13 -1.60 -3.75E-01
3717 236754 at 3.2795E-02 2.23E-03 3.13 -1.60 3.29E-01
3718 244733 at 3.2802E-02 2.23E-03 3.13 -1.60 2.30E-01
3719 LRP12 219631 at 3.2817E-02 2.23E-03 -3.13 -1.61 -4.23E-01
3720 PSMF1 201052 s at 3.2852E-02 2.24E-03 -3.13 -1.61 -5.45E-01
3721 216757 at 3.2852E-02 2.24E-03 3.13 -1.61 1.29E-01
3722 ADH1B 209612 s at 3.2852E-02 2.24E-03 -3.13 -1.61 -1.04E+00
3723 SLC31A1 236217 at 3.2852E-02 2.24E-03 -3.13 -1.61 -2.91 E-01
3724 COX7C 201134 x at 3.2852E-02 2.24E-03 3.13 -1.61 3.1 E-01
3725 ZNF529 215307 at 3.2890E-02 2.24E-03 3.13 -1.61 2.76E-01
3726 ARHGEF10 221656_s_at 3.2937E-02 2.24E-03 -3.13 -1.61 -4.24E-01 L
3727 A N1 226258 at 3.2937E-02 2.25E-03 3.13 -1.61 4.23E-01
3728 RNF24 204669 s at 3.2937E-02 2.25E-03 -3.13 -1.61 -3.10E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
3729 ZNF684 244398 x at 3.3038E-02 2.25E-03 3.12 -1.61 2.11E-01
3730 1569858_at 3.3051 E-02 2.26E-03 3.12 -1.61 9.69E-02
3731 AQP10 1555338 s at 3.3051 E-02 2.26E-03 3.12 -1.61 1.49E-01
3732 SPHK1 219257 s at 3.3051 E-02 2.26E-03 -3.12 -1.61 -3.94E-01
3733 ARL3 1568590 at 3.3055E-02 2.26E-03 3.12 -1.61 1.43E-01
3734 CCDC88A 239233 at 3.3065E-02 2.26E-03 -3.12 -1.62 -1.14E-01
3735 GOPC 227215 at 3.3088E-02 2.26E-03 -3.12 -1.62 -2.66E-01
3736 RPS8P10/// 214089_at 3.3091 E-02 2.26E-03 3.12 -1.62 1.92E-01 RPS8
3737 YWHAE 210996 s at 3.3095E-02 2.26E-03 -3.12 -1.62 -3.36E-01
3738 FUCA2 223120 at 3.3095E-02 2.26E-03 -3.12 -1.62 -3.29E-01
3739 1570331 at 3.3100E-02 2.26E-03 3.12 -1.62 1.37E-01
3740 1560240 at 3.3100E-02 2.26E-03 3.12 -1.62 1.13E-01
3741 LOC100130 1558782_a_at 3.3100E-02 2.26E-03 3.12 -1.62 2.16E-01 557
3742 LOC441461 1558689 a at 3.3121 E-02 2.27E-03 3.12 -1.62 1.65E-01
3743 LOC727842 217015 at 3.3122E-02 2.27E-03 3.12 -1.62 1.09E-01
3744 HLA- 217436_x_at 3.3138E-02 2.27E-03 -3.12 -1.62 -3.51 E-01
J///HLA-
H///HLA-
G///HLA-
B///HLA-A
3745 CBX3 200037 s at 3.3183E-02 2.27E-03 3.12 -1.62 2.33E-01
3746 PPFIBP2 212841 s at 3.3219E-02 2.28E-03 -3.12 -1.62 -2.83E-01
3747 HIST1 H1A 208484 at 3.3219E-02 2.28E-03 3.12 -1.62 1.69E-01
3748 SMEK1 220369 at 3.3219E-02 2.28E-03 3.12 -1.62 2.35E-01
3749 FLJ 10038 205510 s at 3.3219E-02 2.28E-03 3.12 -1.62 2.29E-01
3750 ITCH 217094 s at 3.3242E-02 2.28E-03 -3.12 -1.62 -2.81 E-01
3751 NCLN 222206 s at 3.3267E-02 2.28E-03 -3.12 -1.62 -2.41 E-01
3752 C11orf87 1557181 s at 3.3282E-02 2.28E-03 3.12 -1.63 1.21 E-01
3753 OR1 F2P 217308 at 3.3282E-02 2.28E-03 3.12 -1.63 1.45E-01
3754 RAD23B 201222 s at 3.3299E-02 2.29E-03 -3.12 -1.63 -4.04E-01
3755 C1orf97 224443 at 3.3345E-02 2.29E-03 3.12 -1.63 4.46E-01
3756 YBX2 219704 at 3.3414E-02 2.30E-03 3.12 -1.63 1.79E-01
3757 PASK 213534 s at 3.3414E-02 2.30E-03 3.12 -1.63 5.88E-01
3758 FKBP1 1 219117 s at 3.3414E-02 2.30E-03 -3.12 -1.63 -4.43E-01
3759 BCL7A 203795 s at 3.3414E-02 2.30E-03 3.12 -1.63 2.03E-01
3760 HAUS7///TR 207891_s_at 3.3416E-02 2.30E-03 -3.12 -1.63 -3.00E-01 EX2
3761 LRP12 220253 s at 3.3420E-02 2.30E-03 -3.12 -1.63 -4.49E-01
3762 KLHDC1 1552733 at 3.3457E-02 2.30E-03 3.12 -1.63 2.62E-01
3763 ATL2 222700 at 3.3457E-02 2.30E-03 3.12 -1.63 3.23E-01
3764 C19orf2 222266 at 3.3457E-02 2.30E-03 3.12 -1.63 4.50E-01
3765 1566146 x at 3.3457E-02 2.30E-03 3.12 -1.63 1.93E-01
3766 242216 at 3.3457E-02 2.30E-03 3.12 -1.63 1.21 E-01
3767 PSIP1 210758 at 3.3480E-02 2.31 E-03 3.12 -1.63 2.46E-01
3768 233747 at 3.3482E-02 2.31 E-03 3.12 -1.63 1.28E-01
3769 BEX2 224367 at 3.3560E-02 2.31 E-03 3.12 -1.64 5.51 E-01
3770 TRAF3IP3 205804 s at 3.3571 E-02 2.32E-03 3.12 -1.64 4.06E-01
3771 VEZF1 202173 s at 3.3571 E-02 2.32E-03 -3.12 -1.64 -3.97E-01
3772 RAB35 221819 at 3.3571 E-02 2.32E-03 -3.12 -1.64 -3.04E-01
3773 VPS35 233864 s at 3.3571 E-02 2.32E-03 -3.12 -1.64 -2.22E-01
3774 A ACR 21711 1 at 3.3571 E-02 2.32E-03 3.12 -1.64 1.42E-01
3775 C20orf 111 221954 at 3.3571 E-02 2.32E-03 3.12 -1.64 3.41 E-01
3776 232186 at 3.3571 E-02 2.32E-03 -3.12 -1.64 -1.35E-01
3777 215398 at 3.3571 E-02 2.32E-03 3.12 -1.64 1.52E-01
3778 MRPS5 236779 at 3.3571 E-02 2.32E-03 3.12 -1.64 1.86E-01
3779 DNAJC5 224613 s at 3.3571 E-02 2.32E-03 -3.12 -1.64 -2.59E-01
3780 MRPS2 218001 at 3.3571 E-02 2.32E-03 -3.12 -1.64 -4.28E-01
3781 MBNL2 203640 at 3.3571 E-02 2.32E-03 -3.12 -1.64 -3.30E-01
3782 233521 at 3.3571 E-02 2.32E-03 3.12 -1.64 1.18E-01
3783 229226 at 3.3571 E-02 2.32E-03 3.12 -1.64 1.37E-01
3784 TTC28 215146 s at 3.3579E-02 2.32E-03 -3.11 -1.64 -2.67E-01
3785 RHOA 240337 at 3.3579E-02 2.32E-03 3.1 1 -1.64 1.07E-01
3786 PCMTD2 237179 at 3.3585E-02 2.33E-03 3.1 1 -1.64 1.42E-01
3787 227579 at 3.3588E-02 2.33E-03 -3.1 1 -1.64 -2.30E-01
3788 ZBTB7C 217675 at 3.3646E-02 2.33E-03 3.1 1 -1.64 1.11E-01
3789 C1orf97 224444 s at 3.3646E-02 2.33E-03 3.1 1 -1.64 5.43E-01
3790 RNF130 236292 at 3.3653E-02 2.33E-03 -3.1 1 -1.64 -2.40E-01
3791 DDRGK1 218159 at 3.3667E-02 2.34E-03 -3.11 -1.64 -2.54E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
3792 GLTPD1 220734 s at 3.3667E-02 2.34E-03 -3.11 -1.64 -2.68E-01
3793 236149 at 3.3667E-02 2.34E-03 3.11 -1.65 2.13E-01
3794 EGFR 201983 s at 3.3667E-02 2.34E-03 -3.11 -1.65 -4.40E-01
3795 CDKN2A 209644 x at 3.3667E-02 2.34E-03 3.11 -1.65 2.76E-01
3796 TG 2 211003 x at 3.3667E-02 2.34E-03 -3.11 -1.65 -1.94E-01
3797 KIF3B 225205 at 3.3667E-02 2.34E-03 -3.11 -1.65 -3.23E-01
3798 ARL17B 229028 s at 3.3677E-02 2.34E-03 3.11 -1.65 3.61 E-01
3799 GKAP1 234192 s at 3.3677E-02 2.34E-03 3.11 -1.65 2.94E-01
3800 DPH3B 233000 x at 3.3677E-02 2.34E-03 3.11 -1.65 1.64E-01
3801 G2E3 223256 at 3.3677E-02 2.34E-03 3.11 -1.65 2.97E-01
3802 NEUROG3 207965 at 3.3677E-02 2.34E-03 3.11 -1.65 1.33E-01
3803 AIDA 220199 s at 3.3691 E-02 2.34E-03 -3.11 -1.65 -5.97E-01
3804 SNHG4/// 1564907_s_at 3.3744E-02 2.35E-03 3.11 -1.65 2.07E-01 ATR3
3805 243921 at 3.3767E-02 2.35E-03 3.11 -1.65 1.09E-01
3806 IM T 242361 at 3.3781 E-02 2.35E-03 3.11 -1.65 2.20E-01
3807 1562665 at 3.3781 E-02 2.35E-03 3.11 -1.65 9.94E-02
3808 229189 s at 3.3781 E-02 2.36E-03 3.11 -1.65 5.44E-01
3809 NR2F2 209121 x at 3.3781 E-02 2.36E-03 -3.11 -1.65 -5.43E-01
3810 CS 208660 at 3.3781 E-02 2.36E-03 -3.11 -1.65 -4.48E-01
38 1 UNC5B 41856_at 3.3781 E-02 2.36E-03 -3.11 -1.65 -1.59E-01
3812 C21 orf88 1553850 at 3.3781 E-02 2.36E-03 3.11 -1.65 1.16E-01
3813 SVIP 226278 at 3.3781 E-02 2.36E-03 3.11 -1.65 5.54E-01
3814 SLC2A13 1552695 a at 3.3781 E-02 2.36E-03 -3.11 -1.65 -1.79E-01
3815 238201 at 3.3781 E-02 2.36E-03 3.11 -1.65 1.11 E-01
3816 GNPTAB 220398_at 3.3781 E-02 2.36E-03 3.11 -1.65 1.49E-01
3817 1566696_at 3.3781 E-02 2.36E-03 3.11 -1.65 1.41 E-01
3818 C1orf58 241908_at 3.3781 E-02 2.36E-03 3.11 -1.65 2.90E-01
3819 ZNF85 1554445 at 3.3781 E-02 2.36E-03 3.11 -1.65 3.23E-01
3820 KIFAP3 203333 at 3.3781 E-02 2.36E-03 -3.11 -1.65 -3.82E-01
3821 MTUS2 214961_at 3.3781 E-02 2.36E-03 3.11 -1.65 1.19E-01
3822 LOC221122 1560278_at 3.3781 E-02 2.36E-03 3.11 -1.65 2.21 E-01
3823 DPP4 211478 s at 3.3781 E-02 2.36E-03 -3.11 -1.66 -1.96E-01
3824 POLL 221049_s_at 3.3781 E-02 2.36E-03 3.11 -1.66 2.01 E-01
3825 PAFAH1 B2 210160 at 3.3781 E-02 2.36E-03 -3.11 -1.66 -1.78E-01
3826 SP3 238035 at 3.3781 E-02 2.36E-03 3.11 -1.66 2.44E-01
3827 1569345 at 3.3781 E-02 2.36E-03 3.11 -1.66 1.48E-01
3828 MFAP4 212713 at 3.3781 E-02 2.37E-03 -3.11 -1.66 -7.00E-01
3829 221379 at 3.3804E-02 2.37E-03 3.11 -1.66 1.80E-01
3830 KCNE4 1552507 at 3.3804E-02 2.37E-03 -3.11 -1.66 -5.62E-01
3831 C3AR1 209906 at 3.3835E-02 2.37E-03 -3.11 -1.66 -5.73E-01
3832 242597 at 3.3838E-02 2.37E-03 3.11 -1.66 1.40E-01
3833 PHF23 223081 at 3.3839E-02 2.37E-03 -3.11 -1.66 -2.04E-01
3834 CAPRIN1 200722 s at 3.3856E-02 2.37E-03 -3.11 -1.66 -3.80E-01
3835 B P2K 226853 at 3.3865E-02 2.38E-03 -3.11 -1.66 -3.01 E-01
3836 LU 201744 s at 3.3892E-02 2.38E-03 -3.11 -1.66 -7.05E-01
3837 239744 at 3.3905E-02 2.38E-03 3.11 -1.66 2.42E-01
3838 WAPAL 1554441 a at 3.3906E-02 2.38E-03 -3.11 -1.66 -3.69E-01
3839 DCAF8 1554049 s at 3.3906E-02 2.38E-03 -3.11 -1.66 -1.42E-01
3840 TIF3 223357 s at 3.3913E-02 2.38E-03 3.11 -1.66 1.09E-01
3841 1559054 a at 3.3915E-02 2.38E-03 3.11 -1.66 3.03E-01
3842 KDELR1 1555575 a at 3.3931 E-02 2.38E-03 -3.11 -1.66 -3.20E-01
3843 ORMDL3 235136 at 3.3965E-02 2.39E-03 -3.11 -1.66 -3.00E-01
3844 1556185 a at 3.3980E-02 2.39E-03 -3.11 -1.66 -2.06E-01
3845 ESDC2 224679 at 3.3987E-02 2.39E-03 -3.11 -1.67 -2.99E-01
3846 PNPO 222653 at 3.3992E-02 2.39E-03 -3.11 -1.67 -5.02E-01
3847 229190 at 3.4020E-02 2.39E-03 3.11 -1.67 5.46E-01
3848 FLJ 11292 217342 x at 3.4020E-02 2.39E-03 3.11 -1.67 1.38E-01
3849 D ASE2 214992 s at 3.4022E-02 2.40E-03 -3.11 -1.67 -6.63E-01
3850 PTAR1 226110 at 3.4022E-02 2.40E-03 3.11 -1.67 2.74E-01
3851 ARF3 200011 s at 3.4023E-02 2.40E-03 -3.11 -1.67 -5.90E-01
3852 CPM 206100 at 3.4023E-02 2.40E-03 -3.11 -1.67 -6.80E-01
3853 1568905 at 3.4038 E-02 2.40E-03 3.10 -1.67 1.44E-01
3854 241413 at 3.4044E-02 2.40E-03 3.10 -1.67 2.45E-01
3855 ZBTB12 233843 at 3.4046E-02 2.40E-03 3.10 -1.67 1.47E-01
3856 ABHD12 228123 s at 3.4046E-02 2.40E-03 -3.10 -1.67 -6.74E-01
3857 TI P2 203167 at 3.4083E-02 2.40E-03 -3.10 -1.67 -5.62E-01
3858 C3orf15 1561430 s at 3.4099E-02 2.41 E-03 3.10 -1.67 1.22E-01
3859 236799 at 3.4133E-02 2.41 E-03 3.10 -1.67 1.47E-01
Wo. Gene* Probe ID** Adj. p value P value t β Log FC
3860 GCOM1///G 212241_at 3.4157E-02 2.41 E-03 3.10 -1.67 2.33E-01 RINL1A
3861 DKK3 214247 s at 3.4168E-02 2.41 E-03 -3.10 -1.67 -6.82E-01
3862 226458 at 3.4168E-02 2.41 E-03 3.10 -1.67 5.56E-01
3863 SUPT3H 206506 s at 3.4168E-02 2.41 E-03 3.10 -1.67 4.1 1E-01
3864 LRRTM4 220345 at 3.4168E-02 2.41 E-03 3.10 -1.67 1.04E-01
3865 RPL13A 210646 x at 3.4168E-02 2.42E-03 3.10 -1.67 1.29E-01
3866 ABCA1 203504 s at 3.4190E-02 2.42E-03 -3.10 -1.68 -6.20E-01
3867 AKIRIN2 223145 s at 3.4197E-02 2.42 E-03 -3.10 -1.68 -3.74E-01
3868 UBAP1 221490 at 3.4197E-02 2.42E-03 -3.10 -1.68 -2.29E-01
3869 PCSK5 213652_at 3.4197E-02 2.42E-03 -3.10 -1.68 -3.78E-01
3870 AVL9 244355_at 3.4200E-02 2.42E-03 3.10 -1.68 1.73E-01
3871 PCYT1A 225069 at 3.4200E-02 2.42E-03 -3.10 -1.68 -2.45E-01
3872 SAMD9 228531 at 3.4202E-02 2.42E-03 3.10 -1.68 2.86E-01
3873 1562038 at 3.4202E-02 2.42E-03 3.10 -1.68 1.11E-01
3874 SOX6 235526 at 3.4202E-02 2.42E-03 3.10 -1.68 1.44E-01
3875 TCEB2 213877 x at 3.4231 E-02 2.43E-03 3.10 -1.68 2.01E-01
3876 CA5BP 238435 at 3.4231 E-02 2.43E-03 3.10 -1.68 2.11E-01
3877 222096 x at 3.4231 E-02 2.43E-03 3.10 -1.68 1.76E-01
3878 NSF 202395 at 3.4239E-02 2.43E-03 -3.10 -1.68 -2.94E-01
3879 PTMS 218044 x at 3.4239E-02 2.43E-03 3.10 -1.68 1.88E-01
3880 1560550 at 3.4254E-02 2.43E-03 3.10 -1.68 1.57E-01
3881 239753 at 3.4261 E-02 2.43E-03 3.10 -1.68 1.93E-01
3882 MYL2 209742 s at 3.4299E-02 2.44E-03 3.10 -1.68 1.18E-01
3883 MGEA5 223494 at 3.4299E-02 2.44E-03 3.10 -1.68 4.23E-01
3884 SPAG4 219888 at 3.4309E-02 2.44E-03 -3.10 -1.68 -4.16E-01
3885 SLC46A1 1558703 at 3.4309E-02 2.44E-03 -3.10 -1.68 -2.33E-01
3886 C11 orf30 234669 x at 3.4309E-02 2.44E-03 3.10 -1.68 1.69E-01
3887 ADH1 B 209613 s at 3.4322E-02 2.44E-03 -3.10 -1.68 -1.13E+00
3888 SLC25A11 207088 s at 3.4325E-02 2.44E-03 -3.10 -1.68 -4.92E-01
3889 RPL13A 212790 x at 3.4350E-02 2.44E-03 3.10 -1.68 1.60E-01
3890 MFF 223354_x_at 3.4350E-02 2.44E-03 -3.10 -1.68 -3.18E-01
3891 TMC06 213550 s at 3.4350E-02 2.44E-03 3.10 -1.68 3.64E-01
3892 1556683_x_at 3.4361 E-02 2.45E-03 3.10 -1.69 1.36E-01
3893 TLL2 208027 s at 3.4393E-02 2.45E-03 3.10 -1.69 9.35E-02
3894 MYOD1 206657 s at 3.4393E-02 2.45E-03 3.10 -1.69 1.76E-01
3895 WDFY3 212598 at 3.4393E-02 2.45E-03 -3.10 -1.69 -1.97E-01
3896 NFIB 230291 s at 3.4396E-02 2.45E-03 -3.10 -1.69 -3.07E-01
3897 215727 x at 3.4414E-02 2.45E-03 3.10 -1.69 1.31E-01
3898 KPNA4 225267 at 3.4442E-02 2.46E-03 -3.10 -1.69 -2.38E-01
3899 243908 at 3.4488E-02 2.46E-03 3.10 -1.69 3.41 E-01
3900 HLA-DRA 208894 at 3.4527E-02 2.46E-03 -3.10 -1.69 -5.23E-01
3901 ANGPTL2 213001 at 3.4530E-02 2.46E-03 -3.10 -1.69 -7.62E-01
3902 DLEU2 1563229 at 3.4530E-02 2.46E-03 3.10 -1.69 2.84E-01
3903 NLRP10 1553534 at 3.4551 E-02 2.47E-03 3.10 -1.69 1.11E-01
3904 ATP5L 210453 x at 3.4565E-02 2.47E-03 3.10 -1.69 3.81 E-01
3905 LILRA6///LIL 210784_x_at 3.4569E-02 2.47E-03 -3.10 -1.69 -4.22E-01 RB3
3906 PFDN4 205362 s at 3.4569E-02 2.47E-03 3.10 -1.69 3.40E-01
3907 KPNB1 213574 s at 3.4570E-02 2.47E-03 -3.10 -1.69 -2.93E-01
3908 PRKAG2 215231 at 3.4624E-02 2.47E-03 3.09 -1.70 1.10E-01
3909 BTN3A3 38241 at 3.4629E-02 2.48E-03 -3.09 -1.70 -4.96E-01
3910 BICD2 213154 s at 3.4629E-02 2.48E-03 -3.09 -1.70 -3.84E-01
3911 LOC642236 242331 x at 3.4629E-02 2.48E-03 3.09 -1.70 1.58E-01
3912 SRP54 203605 at 3.4629E-02 2.48E-03 -3.09 -1.70 -2.82E-01
3913 XP07 208459 s at 3.4641 E-02 2.48E-03 -3.09 -1.70 -2.50E-01
3914 RPL22L1 225541 at 3.4665E-02 2.48E-03 3.09 -1.70 5.07E-01
3915 HMOX2 218120 s at 3.4665E-02 2.48E-03 -3.09 -1.70 -4.41 E-01
3916 AP1S1 205195 at 3.4665E-02 2.48E-03 -3.09 -1.70 -2.17E-01
3917 ATE1 238857 at 3.4747E-02 2.49E-03 3.09 -1.70 1.24E-01
3918 FLJ31958 1553354 a at 3.4747E-02 2.49E-03 3.09 -1.70 1.34E-01
3919 PTHLH 206300 s at 3.4794E-02 2.49E-03 3.09 -1.70 9.27E-02
3920 COL4A3 216893 s at 3.4803E-02 2.50E-03 3.09 -1.70 1.06E-01
3921 FAM120A 200774 at 3.4833E-02 2.50E-03 -3.09 -1.70 -3.17E-01
3922 C1 1orf17 242515 x at 3.4892E-02 2.50E-03 -3.09 -1.71 -2.05E-01
3923 TIMP3 201148 s at 3.4921 E-02 2.51 E-03 -3.09 -1.71 -4.68E-01
3924 DOK2 214054 at 3.4951 E-02 2.51 E-03 -3.09 -1.71 -3.38E-01
3925 RBM39 227223 at 3.4951 E-02 2.51 E-03 3.09 -1.71 4.88E-01
3926 CYTH2 209158 s at 3.4951 E-02 2.51 E-03 -3.09 -1.71 -3.49E-01
33
No. Gene* Probe ID** Adj. p value P value t B Log FC
3983 GALT 203179 at 3.5576E-02 2.59E-03 3.08 -1.74 2.29E-01
3984 SNED1 213488 at 3.5576E-02 2.59E-03 -3.08 -1.74 -2.94E-01
3985 CPD 201943 s at 3.5579E-02 2.59E-03 -3.08 -1.74 -4.49E-01
3986 CLTB 205172 x at 3.5579E-02 2.59E-03 -3.08 -1.74 -2.79E-01
3987 CCDC137 225933 at 3.5585E-02 2.60E-03 -3.08 -1.74 -2.92E-01
3988 DDX19A 202578 s at 3.5585E-02 2.60E-03 -3.08 -1.74 -4.16E-01
3989 CDC37 209953 s at 3.5585E-02 2.60E-03 -3.08 -1.74 -5.39E-01
3990 SLC43A3 210692 s at 3.5607E-02 2.60E-03 -3.08 -1.74 -4.92E-01
3991 NCRNA002 226995_at 3.5608E-02 2.60E-03 -3.08 -1.74 -2.42E-01 05
3992 241114 s at 3.5650E-02 2.60E-03 3.08 -1.74 2.05E-01
3993 PG 1 201968 s at 3.5686E-02 2.61 E-03 -3.08 -1.74 -4.66E-01
3994 SIX1 228347 at 3.5692E-02 2.61 E-03 -3.08 -1.74 -4.57E-01
3995 241891_at 3.5692E-02 2.61 E-03 3.08 -1.74 6.02E-01
3996 RASAL2 222810 s at 3.5692E-02 2.61 E-03 -3.08 -1.74 -3.20E-01
3997 LRRC36 220003 at 3.5692E-02 2.61 E-03 3.08 -1.74 1.55E-01
3998 CCDC85A 233846 at 3.5692E-02 2.61 E-03 3.08 -1.74 1.89E-01
3999 242130_at 3.5699E-02 2.61 E-03 3.08 -1.74 1.36E-01
4000 LOC729580 49679 s at 3.5752E-02 2.62 E-03 -3.08 -1.74 -1.44E-01
4001 TGS1 236371 s at 3.5752E-02 2.62E-03 3.08 -1.74 1.32E-01
4002 HECTD3 218632 at 3.5766E-02 2.62 E-03 -3.08 -1.74 -3.81E-01
4003 230392 at 3.5771 E-02 2.62E-03 3.08 -1.75 1.88E-01
4004 PLSCR3 218828 at 3.5775E-02 2.62E-03 -3.08 -1.75 -2.06E-01
4005 RALGAPA2 239660 at 3.5777E-02 2.62E-03 3.08 -1.75 1.87E-01
4006 PPID 204186 s at 3.5777E-02 2.62E-03 -3.08 -1.75 -4.54E-01
4007 238946 at 3.5783E-02 2.62E-03 3.08 -1.75 1.52E-01
4008 LGALS14 220158 at 3.5813E-02 2.63E-03 3.08 -1.75 3.28E-01
4009 231952 at 3.5813E-02 2.63E-03 3.08 -1.75 3.01 E-01
4010 Sep-04 210657 s at 3.5816E-02 2.63E-03 -3.08 -1.75 -3.07E-01
4011 C20orf191/// 200855_at 3.5816E-02 2.63E-03 3.08 -1.75 1.83E-01 NCOR1
4012 C2orf79 226243 at 3.5827E-02 2.63E-03 3.08 -1.75 4.56E-01
4013 236451 at 3.5827E-02 2.63E-03 3.08 -1.75 2.81 E-01
4014 CRYBG3 214030_at 3.5827E-02 2.63E-03 -3.08 -1.75 -3.18E-01
4015 LOC730102 241607 at 3.5827E-02 2.63E-03 -3.08 -1.75 -1.49E-01
4016 FNDC3A 202304 at 3.5843E-02 2.63E-03 -3.07 -1.75 -2.82 E-01
4017 CRHR1 211897 s at 3.5843E-02 2.63E-03 3.07 -1.75 1.51 E-01
4018 HLA-DQB1 209823_x at 3.5854E-02 2.63E-03 -3.07 -1.75 -7.87E-01
4019 LK13 216670 at 3.5877E-02 2.64E-03 3.07 -1.75 1.59E-01
4020 EDA2R 221399_at 3.5877E-02 2.64E-03 3.07 -1.75 1.62E-01
4021 CTNND1 208862 s at 3.5877E-02 2.64E-03 -3.07 -1.75 -2.80E-01
4022 ZNF404 239043 at 3.5877E-02 2.64E-03 3.07 -1.75 2.85E-01
4023 C7orf44 232330 at 3.5878E-02 2.64E-03 3.07 -1.75 3.77E-01
4024 1564733 at 3.5897E-02 2.64E-03 3.07 -1.75 2.18E-01
4025 CH P4A 218572_at 3.5928E-02 2.64E-03 -3.07 -1.75 -3.75E-01
4026 VPS41 210849 s at 3.5963E-02 2.65E-03 -3.07 -1.76 -3.09E-01
4027 XPNPEP2 206484 s at 3.5963E-02 2.65E-03 -3.07 -1.76 -1.98E-01
4028 T E 182 1555090 x at 3.6033E-02 2.66E-03 3.07 -1.76 1.60E-01
4029 KRTAP19-3 240967_at 3.6033E-02 2.66E-03 3.07 -1.76 1.24E-01
4030 CCDC86 203119 at 3.6033E-02 2.66E-03 -3.07 -1.76 -3.99E-01
4031 PCNX 213159 at 3.6033E-02 2.66E-03 -3.07 -1.76 -3.67E-01
4032 HEXB 201944 at 3.6033E-02 2.66E-03 -3.07 -1.76 -4.11 E-01
4033 CDC34 212540 at 3.6034E-02 2.66E-03 -3.07 -1.76 -3.09E-01
4034 THBD 237252 at 3.6052E-02 2.66E-03 -3.07 -1.76 -2.16E-01
4035 239263 at 3.6058E-02 2.66E-03 3.07 -1.76 1.67E-01
4036 JUNB 201473 at 3.6073E-02 2.66E-03 -3.07 -1.76 -4.22E-01
4037 FA2H 234963 s at 3.6114E-02 2.67E-03 3.07 -1.76 1.50E-01
4038 APEH 201284 s at 3.6148E-02 2.67E-03 -3.07 -1.76 -3.92E-01
4039 RARS 201330 at 3.6152E-02 2.67E-03 -3.07 -1.76 -2.85E-01
4040 ZNF395 222536 s at 3.6160E-02 2.67E-03 3.07 -1.76 2.12E-01
4041 CDAN1 228516 at 3.6 95E-02 2.68E-03 3.07 -1.76 2.25E-01
4042 C6orf52 236504 x at 3.6195E-02 2.68E-03 3.07 -1.76 2.39E-01
4043 RALBP1 202844 s at 3.6211 E-02 2.68E-03 -3.07 -1.76 -4.23E-01
4044 CTBP2 210835 s at 3.6240E-02 2.68E-03 -3.07 -1.77 -3.78E-01
4045 NUP98 203194 s at 3.6240E-02 2.68E-03 -3.07 -1.77 -4.32E-01
4046 236174 at 3.6240E-02 2.68E-03 3.07 -1.77 1.87E-01
4047 UBE2L3 200683 s at 3.6245E-02 2.68E-03 -3.07 -1.77 -4.23E-01
4048 230714 s at 3.6245E-02 2.68E-03 3.07 -1.77 2.58E-01
4049 1559524 at 3.6247E-02 2.68E-03 3.07 -1.77 1.78E-01
No. Gene* Probe ID** Adj. p value P value ί B Log FC
4050 TTC3 210645 s at 3.6247E-02 2.68E-03 -3.07 -1.77 -4.18E-01
4051 238881 at 3.6262E-02 2.69E-03 3.07 -1.77 1.05E-01
4052 C16orf42 213104 at 3.6318E-02 2.69E-03 -3.07 -1.77 -3.08E-01
4053 MRP63 204386 s at 3.6325E-02 2.69E-03 3.07 -1.77 2.89E-01
4054 ZNF451 231885 at 3.6332E-02 2.69E-03 3.07 -1.77 1.05E-01
4055 FIGN 222956 at 3.6336E-02 2.70E-03 3.07 -1.77 1.42E-01
4056 226865 at 3.6336E-02 2.70E-03 -3.07 -1.77 -6.54E-01
4057 HBP1 236645 at 3.6347E-02 2.70E-03 3.07 -1.77 1.48E-01
4058 HOOK3 1558315 s at 3.6353E-02 2.70 E-03 -3.07 -1.77 -1.25E-01
4059 TPRA1 218855 at 3.6413E-02 2.70E-03 -3.07 -1.77 -2.46E-01
4060 YBX1 208627 s at 3.6413E-02 2.70E-03 -3.07 -1.77 -4.72E-01
4061 CAMK4 241871 at 3.6448E-02 2.71 E-03 3.07 -1.77 4.13E-01
4062 C2 1554533 at 3.6450E-02 2.71 E-03 -3.07 -1.77 -5.03E-01
4063 1564083 at 3.6460E-02 2.71 E-03 3.07 -1.78 1.06E-01
4064 243220 at 3.6460E-02 2.71 E-03 3.07 -1.78 1.17E-01
4065 TGOLN2 203833 s at 3.6460E-02 2.71 E-03 -3.07 -1.78 -4.01 E-01
4066 LEKR1 1559105 at 3.6473E-02 2.71 E-03 3.07 -1.78 1.36E-01
4067 YWHAE 213655_at 3.6475E-02 2.71 E-03 -3.07 -1.78 -3.48E-01
4068 244243 at 3.6475E-02 2.71 E-03 3.07 -1.78 1.17E-01
4069 MAP3K2 1565130 at 3.6475E-02 2.71 E-03 3.06 -1.78 9.96E-02
4070 HNRNPUL2 227608 at 3.6477E-02 2.72E-03 -3.06 -1.78 -4.98E-01
4071 GAS7 210872 x at 3.6477E-02 2.72E-03 -3.06 -1.78 -2.22E-01
4072 KIAA0101 211713 x at 3.6477E-02 2.72E-03 3.06 -1.78 3.27E-01
4073 SLC26A1 205058 at 3.6477E-02 2.72E-03 3.06 -1.78 1.76E-01
4074 COPS8 202143 s at 3.6477E-02 2.72E-03 -3.06 -1.78 -4.32E-01
4075 KEAP1 202417 at 3.6477E-02 2.72E-03 -3.06 -1.78 -3.91 E-01
4076 RELA 201783 s at 3.6477E-02 2.72E-03 -3.06 -1.78 -4.35E-01
4077 TNIP2 232160 s at 3.6495E-02 2.72E-03 -3.06 -1.78 -2.21 E-01
4078 230703 at 3.6495E-02 2.72E-03 3.06 -1.78 3.15E-01
4079 RALBP1 202845 s at 3.6501 E-02 2.72E-03 -3.06 -1.78 -3.45E-01
4080 IP011 1557770 at 3.6511 E-02 2.72E-03 3.06 -1.78 1.39E-01
4081 USP33 214843 s at 3.6513E-02 2.73E-03 3.06 -1.78 3.12 E-01
4082 C1orf50 62212 at 3.6584E-02 2.73E-03 3.06 -1.78 3.78E-01
4083 ITGA7 216331 at 3.6601 E-02 2.73E-03 -3.06 -1.78 -3.06 E-01
4084 SMAD7 204790 at 3.6601 E-02 2.73E-03 -3.06 -1.78 -4.41 E-01
4085 233407 at 3.6601 E-02 2.74E-03 3.06 -1.78 9.51 E-02
4086 WDR33 222763 s at 3.6601 E-02 2.74E-03 3.06 -1.78 2.43E-01
4087 1560784 x at 3.6601 E-02 2.74E-03 3.06 -1.78 1.48E-01
4088 239601 at 3.6611 E-02 2.74E-03 3.06 -1.78 1.62E-01
4089 AGTRAP 225059 at 3.6635E-02 2.74E-03 -3.06 -1.78 -3.38E-01
4090 APOL6 1557236 at 3.6635E-02 2.74E-03 -3.06 -1.79 -4.31 E-01
4091 PRSS23 202458 at 3.6638E-02 2.74E-03 -3.06 -1.79 -6.94E-01
4092 FAM184A 220150 s at 3.6650E-02 2.74E-03 3.06 -1.79 3.33E-01
4093 CPXM1 227860 at 3.6657E-02 2.74E-03 -3.06 -1.79 -7.33E-01
4094 ALDH1 L2 231202 at 3.6660E-02 2.75E-03 -3.06 -1.79 -3.74E-01
4095 MGC2848 1553936 a at 3.6660E-02 2.75E-03 3.06 -1.79 1.55E-01
4096 UEVLD 1554397 s at 3.6660E-02 2.75E-03 -3.06 -1.79 -4.83E-01
4097 NOTCH1 223508 at 3.6660E-02 2.75E-03 3.06 -1.79 1.53E-01
4098 LOC100133 233993_at 3.6665E-02 2.75E-03 3.06 -1.79 1.51 E-01 790
4099 GAS2L1 31874 at 3.6665E-02 2.75E-03 -3.06 -1.79 -4.66E-01
4100 240069 at 3.6665E-02 2.75E-03 -3.06 -1.79 -2.07E-01
4101 243847 at 3.6682E-02 2.75E-03 3.06 -1.79 9.74E-02
4102 KRTCAP3 235148 at 3.6682E-02 2.75E-03 3.06 -1.79 1.74E-01
4103 PILRA 219788 at 3.6682E-02 2.75E-03 -3.06 -1.79 -5.36E-01
4104 C4orf32 227856 at 3.6700E-02 2.76E-03 -3.06 -1.79 -3.62E-01
4105 MPH0SPH9 1558369 at 3.6700E-02 2.76E-03 3.06 -1.79 2.95E-01
4106 TBC1 D14 224622 at 3.6700E-02 2.76E-03 -3.06 -1.79 -2.59E-01
4107 0LA1 219293 s at 3.6700E-02 2.76E-03 3.06 -1.79 2.58E-01
4108 NDFIP2 224801 at 3.6700E-02 2.76E-03 3.06 -1.79 3.00E-01
4109 ERP44 208959 s at 3.6700E-02 2.76E-03 -3.06 -1.79 -2.07E-01
4110 LOC90834 233321 x at 3.6709E-02 2.76E-03 3.06 -1.79 1.41 E-01
41 11 FASN 212218 s at 3.6709E-02 2.76E-03 -3.06 -1.79 -2.56E-01
4112 RSBN1 213694 at 3.6709E-02 2.76E-03 3.06 -1.79 3.02E-01
41 13 WBP11 217822 at 3.6709E-02 2.76E-03 -3.06 -1.79 -2.63E-01
4114 CA12 203963 at 3.6711 E-02 2.76E-03 -3.06 -1.79 -9.44E-01
4115 235017 s at 3.6732E-02 2.76E-03 3.06 -1.79 1.82E-01
41 16 DCLK1 215303 at 3.6735E-02 2.77E-03 -3.06 -1.79 -1.44E-01
41 17 232690 at 3.6797E-02 2.77E-03 3.06 -1.79 1.97E-01
Wo. Gene* Probe ID" Adj. p value P value f B Log FC
41 18 UBA5 222578 s at 3.6797E-02 2.77E-03 -3.06 -1.79 -2.34E-01
4119 NOM03///N 217225_x_at 3.6798E-02 2.77E-03 -3.06 -1.80 -3.22E-01 OM02///NO
M01
4120 235752 at 3.6813E-02 2.77E-03 3.06 -1.80 1.57E-01
4121 DBF4B 206661 at 3.6813E-02 2.78E-03 3.06 -1.80 1.03E-01
4122 TMEM192 226589 at 3.6813E-02 2.78E-03 -3.06 -1.80 -1.92E-01
4123 C8orf44///S 220038_at 3.6813E-02 2.78E-03 -3.06 -1.80 -5.66E-01 GK3
4124 LOC 100288 230631_s_at 3.6828E-02 2.78E-03 -3.06 -1.80 -3.23E-01 432
4125 TEX261 212083 at 3.6846E-02 2.78E-03 -3.06 -1.80 -4.48E-01
4126 THAP8 228500 at 3.6846E-02 2.78E-03 -3.06 -1.80 -2.37E-01
4127 HHLA3 220387 s at 3.6850E-02 2.78E-03 -3.06 -1.80 -2.97E-01
4128 STK17A 202693 s at 3.6850E-02 2.78E-03 3.06 -1.80 4.14E-01
4129 RLF 204243 at 3.6866E-02 2.78E-03 3.06 -1.80 2.38E-01
4130 RNASEH1 218497 s at 3.6866E-02 2.79E-03 -3.06 -1.80 -3.46E-01
4131 C9orf167 219620 x at 3.6866E-02 2.79E-03 -3.06 -1.80 -2.88E-01
4132 LOC144438 225493 at 3.6866E-02 2.79E-03 3.06 -1.80 2.22E-01
4133 HSPA13 202558 s_at 3.6870E-02 2.79E-03 -3.06 -1.80 -3.47E-01
4134 TAGLN2 200916 at 3.6870E-02 2.79E-03 -3.06 -1.80 -4.90E-01
4135 236293 at 3.691 OE-02 2.79E-03 3.06 -1.80 5.59E-01
4136 LOC643923 1564787_at 3.691 OE-02 2.79E-03 3.06 -1.80 1.95E-01
4137 230354 at 3.691 OE-02 2.79E-03 -3.06 -1.80 -3.21 E-01
4138 TIMP3 201147 s at 3.691 OE-02 2.79E-03 -3.06 -1.80 -7.25E-01
4139 EIF5 208705 s at 3.6911 E-02 2.79E-03 -3.06 -1.80 -2.80E-01
4140 CYR61 210764 s at 3.6937E-02 2.80E-03 -3.06 -1.80 -8.31E-01
4141 ENTHD1 1552393 at 3.6955E-02 2.80E-03 3.06 -1.80 1.19E-01
4142 ME2 209397 at 3.6955E-02 2.80E-03 -3.05 -1.80 -2.05E-01
4143 CHURC1 233268 s at 3.6955E-02 2.80E-03 3.05 -1.80 5.15E-01
4144 244185 at 3.6955E-02 2.80E-03 3.05 -1.80 3.52E-01
4145 NAALAD2 233815 at 3.6982E-02 2.80E-03 3.05 -1.81 1.58E-01
4146 CYB561 210816 s at 3.6986E-02 2.80E-03 -3.05 -1.81 -1.89E-01
4147 244384 at 3.6991 E-02 2.81 E-03 3.05 -1.81 1.53E-01
4148 SLIT2 230130 at 3.7016E-02 2.81 E-03 -3.05 -1.81 -3.38E-01
4149 LOC100129 1566906_at 3.7047E-02 2.81 E-03 3.05 -1.81 2.55E-01 722
4150 NOTCH2 202443 x at 3.7047E-02 2.81 E-03 -3.05 -1.81 -3.26E-01
41 51 TMEM80 1559132 at 3.7050E-02 2.81 E-03 3.05 -1.81 2.41 E-01
41 52 TRIM61 238990 x at 3.7050E-02 2.81 E-03 3.05 -1.81 3.61 E-01
4153 1562189 at 3.7050E-02 2.81 E-03 3.05 -1.81 1.21 E-01
4154 202225 at 3.7105E-02 2.82E-03 -3.05 -1.81 -2.78E-01
4155 215327 at 3.7108E-02 2.82E-03 3.05 -1.81 1.55E-01
4156 ATP13A2 218608 at 3.7108E-02 2.82E-03 -3.05 -1.81 -5.30E-01
4157 TIAM2 219950 s at 3.711 OE-02 2.82E-03 3.05 -1.81 1.52E-01
4158 ZNF668 219047 s at 3.7153E-02 2.83E-03 -3.05 -1.81 -1.91 E-01
4159 DMD 208086 s at 3.7170E-02 2.83E-03 3.05 -1.81 1.40E-01
4160 ACACB 1552616 a at 3.7170E-02 2.83E-03 3.05 -1.81 1.28E-01
4161 1564996 at 3.7170E-02 2.83E-03 3.05 -1.81 1.33E-01
4162 ADAT2 236817 at 3.7170E-02 2.83E-03 3.05 -1.81 1.37E-01
4163 ZNF645 1552967 at 3.7170E-02 2.83E-03 3.05 -1.81 1.28E-01
4164 KLF7 204334 at 3.7170E-02 2.83E-03 -3.05 -1.81 -3.41 E-01
4165 BMPR2 231873 at 3.7170E-02 2.83E-03 -3.05 -1.81 -3.23E-01
4166 WT1 216953 s at 3.7183E-02 2.83E-03 3.05 -1.81 1.66E-01
4167 UTS2R 1553262 a at 3.7183E-02 2.83E-03 3.05 -1.81 1.39E-01
4168 T ED5 1558814 s at 3.7213E-02 2.84E-03 3.05 -1.82 2.18E-01
4169 KBTBD3 228777 at 3.7244E-02 2.84E-03 3.05 -1 .82 6.56E-01
4170 AURKA 208080 at 3.7251 E-02 2.84E-03 3.05 -1 .82 1.47E-01
4171 GJD2 221407 at 3.7252E-02 2.84E-03 3.05 -1.82 2.06E-01
4172 CNOT7 225053 at 3.7252E-02 2.84 E-03 3.05 -1.82 2.07E-01
4173 GTPBP10 239773 at 3.7258E-02 2.84E-03 3.05 -1.82 1.39E-01
4174 SIRPA 202897 at 3.7258E-02 2.84E-03 -3.05 -1.82 -5.06E-01
4175 215212 at 3.7261 E-02 2.85E-03 3.05 -1.82 9.61 E-02
4176 SFTPC 214387 x at 3.7265E-02 2.85E-03 3.05 -1.82 1.73E-01
4177 RPL14 219138 at 3.7273E-02 2.85E-03 3.05 -1.82 4.27E-01
4178 1566596 at 3.7297E-02 2.85E-03 3.05 -1.82 1.40E-01
4179 TSPAN14 223314 at 3.7308 E-02 2.85E-03 -3.05 -1.82 -4.08E-01
4180 15621 16 at 3.7308E-02 2.85E-03 3.05 -1.82 1.35E-01
4181 GALC 204417 at 3.7308E-02 2.85E-03 -3.05 -1.82 -4.01 E-01
31
No. Gene* Probe ID** Adj. p value P value f B Log FC
4182 PA3 209507 at 3.7328E-02 2.86E-03 3.05 -1.82 5.41 E-01
4183 237512 at 3.7328E-02 2.86E-03 3.05 -1.82 1.40E-01
4184 FA 66C 1570396 at 3.7328E-02 2.86E-03 3.05 -1.82 8.16E-02
4185 LOC 100129 227406_at 3.7328E-02 2.86E-03 3.05 -1.82 2.97E-01 387
4186 TFPI 210664 s at 3.7328E-02 2.86E-03 -3.05 -1.82 -5.09E-01
4187 BAHCC1 1559049 a at 3.7328E-02 2.86E-03 3.05 -1.82 1.21 E-01
4188 ETV6 239364 at 3.7349E-02 2.86E-03 -3.05 -1.82 -2.27E-01
4189 FA 46A 224973 at 3.7361 E-02 2.86E-03 -3.05 -1.82 -3.60E-01
4190 PMS2L3 217488 x at 3.7375E-02 2.86E-03 3.05 -1.82 1.68E-01
4191 DGKB 216307 at 3.7375E-02 2.86E-03 3.05 -1.82 8.49E-02
4192 S ARCA2 212257 s at 3.7376E-02 2.87E-03 -3.05 -1.82 -4.01 E-01
4193 FLJ44606 244761 at 3.7376E-02 2.87E-03 3.05 -1.82 1.96E-01
4194 APLP2 208704 x at 3.7376E-02 2.87E-03 -3.05 -1.82 -4.13E-01
4195 1561762 s at 3.7401 E-02 2.87E-03 3.05 -1.83 1.68E-01
4196 TXN2 209078 s at 3.7403E-02 2.87E-03 -3.05 -1.83 -3.19E-01
4197 1558320 at 3.7409E-02 2.87E-03 3.05 -1.83 1.12E-01
4198 ZNF503 232178 at 3.7409E-02 2.87E-03 3.05 -1.83 1.31 E-01
4199 KCNE4 222379 at 3.7424E-02 2.87E-03 -3.05 -1.83 -4.46E-01
4200 228792 at 3.7444E-02 2.88E-03 3.05 -1.83 9.09E-02
4201 LIMS1 207198 s at 3.7454E-02 2.88E-03 -3.05 -1.83 -3.75E-01
4202 RALB 202100 at 3.7454E-02 2.88E-03 -3.05 -1.83 -3.74E-01
4203 TFG 239385 at 3.7454E-02 2.88E-03 3.05 -1.83 2.34E-01
4204 BVES 223853_at 3.7454E-02 2.88E-03 3.05 -1.83 1.29E-01
4205 C4B///C4A 214428 x at 3.7456E-02 2.88E-03 -3.05 -1.83 -4.53E-01
4206 FITM2 233061 at 3.7492E-02 2.88E-03 3.05 -1.83 1.38E-01
4207 1559119 at 3.7497E-02 2.89E-03 3.05 -1.83 1.78E-01
4208 LEF1 221558_s_at 3.7497E-02 2.89E-03 3.05 -1.83 4.88E-01
4209 TRPV2 219282 s at 3.7497E-02 2.89E-03 -3.04 -1.83 -3.33E-01
4210 C12orf65 232650 at 3.7497E-02 2.89E-03 3.04 -1.83 1.54E-01
421 1 GPR6 1553507 a at 3.7499E-02 2.89E-03 3.04 -1.83 1.97E-01
4212 230396 at 3.7535E-02 2.89E-03 3.04 -1.83 1.51 E-01
4213 RARRES1 206391 at 3.7592E-02 2.90E-03 -3.04 -1.83 -6.38E-01
4214 Mar-07 232371 at 3.7592E-02 2.90E-03 3.04 -1.83 2.20E-01
4215 EFEMP2 206580 s at 3.7592 E-02 2.90E-03 -3.04 -1.83 -5.23E-01
4216 SNORA28 241843 at 3.7592E-02 2.90E-03 3.04 -1.83 1.94E-01
4217 224546 at 3.7644E-02 2.90E-03 3.04 -1.84 1.64E-01
4218 CD36 209555 s at 3.7673E-02 2.91 E-03 -3.04 -1.84 -6.61 E-01
4219 VCAN 204620 s at 3.7673E-02 2.91 E-03 -3.04 -1.84 -1.14E+00
4220 MTRF1 L 225206 s at 3.7673E-02 2.91 E-03 -3.04 -1.84 -2.29E-01
4221 LRRC32 203835 at 3.7722E-02 2.91 E-03 -3.04 -1.84 -4.62E-01
4222 EPC1 234969 s at 3.7722E-02 2.91 E-03 3.04 -1.84 2.07E-01
4223 SYNJ1 207594 s at 3.7726E-02 2.91 E-03 -3.04 -1.84 -1.43E-01
4224 1562529 s at 3.7766E-02 2.92E-03 3.04 -1.84 5.86E-01
4225 COL3A1 21 1161 s at 3.7809E-02 2.92E-03 -3.04 -1.84 -1.02E+00
4226 CALCOC02 210817 s at 3.7836E-02 2.93E-03 -3.04 -1.84 -3.23E-01
4227 PCA3 232575 at 3.7836E-02 2.93E-03 3.04 -1.84 1.27E-01
4228 C5orf41 235556 at 3.7836E-02 2.93E-03 3.04 -1.84 2.84E-01
4229 DCAF7 224730 at 3.7875E-02 2.93E-03 -3.04 -1.84 -5.02E-01
4230 RPL13 212933 x at 3.7875E-02 2.93E-03 3.04 -1.84 1.08E-01
4231 FERMT2 209210 s at 3.7983E-02 2.94E-03 -3.04 -1.85 -5.35E-01
4232 235842 at 3.8002E-02 2.94E-03 3.04 -1.85 1.60E-01
4233 LOC285943 230080 at 3.8009E-02 2.94E-03 3.04 -1.85 1.73E-01
4234 EPDR1 223253 at 3.8056E-02 2.95E-03 -3.04 -1.85 -5.59E-01
4235 ATG13 203364 s at 3.8060E-02 2.95E-03 -3.04 -1.85 -2.95E-01
4236 SMTN 209427 at 3.8084E-02 2.95E-03 -3.04 -1.85 -3.01 E-01
4237 242715 at 3.8099E-02 2.95E-03 3.04 -1.85 1.44E-01
4238 RPS28 208904 s at 3.8136E-02 2.96E-03 3.04 -1.85 1.53E-01
4239 LOC400604 241405 at 3.8136E-02 2.96E-03 3.04 -1.85 1.61 E-01
4240 RPL7L1 224738 x at 3.8185E-02 2.96E-03 -3.04 -1.85 -2.36E-01
4241 231925 at 3.8193E-02 2.96E-03 -3.04 -1.85 -2.64E-01
4242 SPNS1 223173 at 3.8219E-02 2.97E-03 -3.04 -1.85 -3.26E-01
4243 238379 x at 3.8237E-02 2.97E-03 3.04 -1.85 1.92E-01
4244 COL1A2 202404 s at 3.8292E-02 2.97E-03 -3.04 -1.86 -1.23E+00
4245 MED23 223946 at 3.831 1 E-02 2.97E-03 3.04 -1.86 2.06E-01
4246 C21orf2 221975 s at 3.8311 E-02 2.98E-03 3.04 -1.86 1.74E-01
4247 CARS2 231023 at 3.831 1 E-02 2.98E-03 3.04 -1.86 1.32E-01
4248 RB 23 219816 s at 3.8311 E-02 2.98E-03 -3.04 -1.86 -3.89E-01
4249 C6orf115 223361 at 3.8313E-02 2.98E-03 3.03 -1.86 4.71 E-01
32
No. Gene* Probe ID** Adj. p value P value f B Log FC
4250 LOC653354/ 214749_s_at 3.8313E-02 2.98E-03 3.03 -1.86 1.99E-01 //AR CX6
4251 UNC5B 226899 at 3.8313E-02 2.98E-03 -3.03 -1.86 -4.50E-01
4252 LGALS8 210732 s at 3.8313E-02 2.98E-03 -3.03 -1.86 -5.99E-01
4253 C11orf31 1557799 at 3.8313E-02 2.98E-03 3.03 -1.86 2.62E-01
4254 MLEC 200617 at 3.8314E-02 2.98E-03 -3.03 -1.86 -4.47E-01
4255 SLC2A14/// 222088_s_at 3.8314E-02 2.98E-03 -3.03 -1.86 -5.18E-01 SLC2A3
4256 CPT2 204263 s at 3.8320E-02 2.98E-03 -3.03 -1.86 -3.85E-01
4257 LAGE3 221982 x at 3.8373E-02 2.99E-03 3.03 -1.86 1.99E-01
4258 232974 at 3.8397E-02 2.99E-03 3.03 -1.86 2.42E-01
4259 1569656 at 3.8426E-02 2.99E-03 3.03 -1.86 9.46E-02
4260 GCL 236140_at 3.8426E-02 2.99E-03 -3.03 -1.86 -3.23E-01
4261 CYP51A1 216607_s_at 3.8426E-02 2.99E-03 -3.03 -1.86 -3.37E-01
4262 ASB7 233807_at 3.8443E-02 3.00E-03 3.03 -1.86 1.37E-01
4263 SFRS15 22231 1_s_at 3.8443E-02 3.00E-03 3.03 -1.86 2.32E-01
4264 UBE2Z 217750 s at 3.8454E-02 3.00E-03 -3.03 -1.86 -2.57E-01
4265 FN3 RP 218210 at 3.8454E-02 3.00E-03 -3.03 -1.86 -3.05E-01
4266 ZNF569 1569366_a_at 3.8454E-02 3.00E-03 3.03 -1.86 2.00E-01
4267 SLC5A3 213167 s at 3.8454E-02 3.00E-03 -3.03 -1.86 -1.63E-01
4268 LASS2 222212 s at 3.8460E-02 3.00E-03 -3.03 -1.86 -3.17E-01
4269 DNAJC1 222621 at 3.8462E-02 3.00E-03 -3.03 -1.87 -2.78E-01
4270 GTPBP8 223486 at 3.8462E-02 3.00E-03 3.03 -1.87 6.48E-01
4271 RPL37A 201429 s at 3.8473E-02 3.01 E-03 3.03 -1.87 7.71 E-02
4272 SPARC 212667 at 3.8473E-02 3.01 E-03 -3.03 -1.87 -7.90E-01
4273 C22orf32 225794 s at 3.8479E-02 3.01 E-03 3.03 -1.87 4.21 E-01
4274 PYGB 201481 s at 3.8479E-02 3.01 E-03 -3.03 -1.87 -2.34E-01
4275 CAT 21 1922 s at 3.8526E-02 3.01 E-03 -3.03 -1.87 -4.50E-01
4276 PPPDE1 222158 s at 3.8563E-02 3.02E-03 -3.03 -1.87 -3.63E-01
4277 GFPT2 205100 at 3.8596E-02 3.02E-03 -3.03 -1.87 -6.1 1 E-01
4278 228726 at 3.86 2E-02 3.02E-03 -3.03 -1.87 -3.70E-01
4279 1557829 at 3.8636E-02 3.02E-03 3.03 -1.87 9.08E-02
4280 SIX5 229009 at 3.8636E-02 3.03E-03 -3.03 -1.87 -2.99E-01
4281 RNF144B 228153 at 3.8636E-02 3.03E-03 -3.03 -1.87 -4.84E-01
4282 FA 200B 236321 at 3.8696E-02 3.03E-03 3.03 -1.87 3.47E-01
4283 C16orf55 230811 at 3.8696E-02 3.03E-03 3.03 -1.87 2.78E-01
4284 WDR5B 219538 at 3.8731 E-02 3.03E-03 3.03 -1.87 2.41 E-01
4285 DUSP6 208892 s at 3.8731 E-02 3.04E-03 -3.03 -1.87 -3.31 E-01
4286 LKL 238025 at 3.8731 E-02 3.04E-03 -3.03 -1.87 -3.78E-01
4287 TEAD2 243766 s at 3.8731 E-02 3.04E-03 3.03 -1.87 2.02E-01
4288 SLC35E1 235035 at 3.8755E-02 3.04E-03 -3.03 -1.88 -2.49E-01
4289 S4A7 223343 at 3.8807E-02 3.04E-03 -3.03 -1.88 -8.96E-01
4290 LRRC39 227532 at 3.8821 E-02 3.05E-03 3.03 -1.88 1.40E-01
4291 VDAC1 217140 s at 3.8821 E-02 3.05E-03 -3.03 -1.88 -4.12E-01
4292 TI 10 218408 at 3.8821 E-02 3.05E-03 3.03 -1.88 4.62E-01
4293 PPP1 R1A 205478 at 3.8821 E-02 3.05E-03 -3.03 -1.88 -3.47E-01
4294 T1 F 217165 x at 3.8832E-02 3.05E-03 -3.03 -1.88 -6.68E-01
4295 IQUB 1568924 a at 3.8850E-02 3.05E-03 3.03 -1.88 1.24E-01
4296 ZCCHC10 223803 s at 3.8863E-02 3.05E-03 3.03 -1.88 4.42E-01
4297 DAGLB 225832 s at 3.8875E-02 3.06E-03 -3.03 -1.88 -3.01 E-01
4298 PARS2 227348 at 3.8923E-02 3.06E-03 -3.03 -1.88 -2.02E-01
4299 1563099 at 3.8923E-02 3.06E-03 3.03 -1.88 9.56E-02
4300 PLA2G2E 221389 at 3.8923E-02 3.06E-03 3.03 -1.88 1.71 E-01
4301 236197 at 3.8936E-02 3.06E-03 3.03 -1.88 1.02E-01
4302 RPL5 1556498 at 3.8940E-02 3.06E-03 3.03 -1.88 1.28E-01
4303 230041 at 3.8945E-02 3.07E-03 3.03 -1.88 1.67E-01
4304 EEA1 204840 s at 3.8949E-02 3.07E-03 -3.03 -1.88 -2.54E-01
4305 FRMD4B 213056 at 3.8949E-02 3.07E-03 -3.03 -1.88 -3.43E-01
4306 CKS2 204170 s at 3.8949E-02 3.07E-03 3.03 -1.88 5.69E-01
4307 1560353 at 3.8949E-02 3.07E-03 3.03 -1.88 1.25E-01
4308 FLJ235 9/// 216798_at 3.8949E-02 3.07E-03 3.03 -1.88 1.64E-01 RNH1
4309 CART1 238574 at 3.8951 E-02 3.07E-03 -3.02 -1.88 -2.12E-01
4310 EPS8 202609 at 3.8958E-02 3.07E-03 -3.02 -1.88 -6.99E-01
431 1 E P1 201324 at 3.8989E-02 3.07E-03 -3.02 -1.89 -8.02E-01
4312 VA P2 201557 at 3.9016E-02 3.08E-03 -3.02 -1.89 -2.75E-01
4313 241228 at 3.9023E-02 3.08E-03 3.02 -1.89 1.12E-01
4314 FAM21A///F 212370_x_at 3.9023E-02 3.08E-03 -3.02 -1.89 -3.23E-01 A 21C///FA
33
No. Gene* Probe ID" Adj. p value P value t B Log FC
M21 B
4315 ZYX 215706 x at 3.9036E-02 3.08E-03 -3.02 -1.89 -5.90E-01
4316 C13orf27 213346 at 3.9036E-02 3.08E-03 3.02 -1.89 6.29E-01
4317 241616 at 3.9037E-02 3.08E-03 3.02 -1.89 1.94E-01
4318 LDLR 202068 s at 3.9043E-02 3.08E-03 -3.02 -1.89 -4.19E-01
4319 CDK19 212897 at 3.9043E-02 3.08E-03 -3.02 -1.89 -2.44E-01
4320 NDUFA11 228689 at 3.9080E-02 3.09E-03 3.02 -1.89 1.64E-01
4321 MIR17HG 233636 at 3.9091 E-02 3.09E-03 3.02 -1.89 9.17E-02
4322 GET4 227588 s at 3.9091 E-02 3.09E-03 3.02 -1.89 1. 7E-01
4323 ZNF140 204523 at 3.911 OE-02 3.09E-03 3.02 -1.89 3.61 E-01
4324 TSGA10 220623 s at 3.91 10E-02 3.09E-03 3.02 -1.89 1.03E-01
4325 1561292 at 3.911 1 E-02 3.09E-03 3.02 -1.89 1.54E-01
4326 OCIAD1 235537 at 3.9159E-02 3.10E-03 3.02 -1.89 2.59E-01
4327 MLXIP 225157 at 3.9194E-02 3.10E-03 -3.02 -1.89 -4.42E-01
4328 RGAG4 227823 at 3.9207E-02 3.10E-03 -3.02 -1.89 -1.84E-01
4329 244312 at 3.9213E-02 3. 0E-03 3.02 -1.89 2.48E-01
4330 ZNF614 220721 at 3.9213E-02 3.11E-03 3.02 -1.89 2.77E-01
4331 CLEC2D 233500 x at 3.9214E-02 3.11 E-03 3.02 -1.89 6.94E-01
4332 VTI1B 225926 at 3.9248E-02 3.11 E-03 -3.02 -1.90 -3.74E-01
4333 ACOX1 227962 at 3.9248E-02 3.11 E-03 -3.02 -1.90 -3.17E-01
4334 237347 at 3.9259E-02 3.11 E-03 3.02 -1.90 2.05E-01
4335 239664 at 3.9259E-02 3.11 E-03 3.02 -1.90 1.04E-01
4336 UBE3C 201817 at 3.9259E-02 3.11 E-03 -3.02 -1.90 -3.24E-01
4337 1556334_s_at 3.9259E-02 3.11 E-03 3.02 -1.90 9.85E-02
4338 TBCD 229192 s at 3.9259E-02 3.11 E-03 -3.02 -1.90 -2.71 E-01
4339 232527 at 3.9267E-02 3.12E-03 3.02 -1.90 3.94E-01
4340 SCN10A 208578 at 3.9275E-02 3.12E-03 3.02 -1.90 1.35E-01
4341 ZNF564 1553957 at 3.9278E-02 3.12E-03 3.02 -1.90 2.24E-01
4342 SIRPB2 1559034 at 3.9278E-02 3.12E-03 -3.02 -1.90 -4.14E-01
4343 DAGLB 226640 at 3.9278E-02 3.12E-03 -3.02 -1.90 -1.76E-01
4344 U2AF1 232141 at 3.9278E-02 3.12E-03 3.02 -1.90 3.02E-01
4345 ARIH2 227932 at 3.9278E-02 3.12E-03 3.02 -1.90 3.43E-01
4346 AGRN 212285 s at 3.9278E-02 3.12E-03 -3.02 -1.90 -2.54E-01
4347 LMX1 B 208487 at 3.9278E-02 3.12E-03 3.02 -1.90 1 82E-01
4348 YARS 212048 s at 3.9278E-02 3.12E-03 -3.02 -1.90 -2.74E-01
4349 IQCB1 205995 x at 3.9278E-02 3.12E-03 3.02 -1.90 2.85E-01
4350 237779 at 3.9282E-02 3.13E-03 3.02 -1.90 1.67E-01
4351 BMP1 205574 x at 3.9282E-02 3.13E-03 -3.02 -1.90 -3.94E-01
4352 ASCC3 231269 at 3.9282E-02 3.13E-03 -3.02 -1.90 -1.45E-01
4353 CYP51A1 202314 at 3.9282E-02 3.13E-03 -3.02 -1.90 -3.47E-01
4354 243919 at 3.9282E-02 3.13E-03 3.02 -1.90 2.13E-01
4355 238311 at 3.9323E-02 3.13E-03 3.02 -1.90 3.06E-01
4356 1556889 s at 3.9323E-02 3.13E-03 3.02 -1.90 1.96E-01
4357 ARHGAP33 233885 at 3.9323E-02 3.13E-03 3.02 -1.90 1.47E-01
4358 CDC5L 209055 s at 3.9334E-02 3.14E-03 -3.02 -1.90 -3.82E-01
4359 238142 at 3.9338E-02 3.14E-03 3.02 -1.90 3.60E-01
4360 ENSA 228851 s at 3.9374E-02 3.14E-03 -3.02 -1.90 -2.98E-01
4361 CLN6 1567081 x at 3.9392E-02 3.14E-03 -3.02 -1.90 -1.88E-01
4362 FBXL20 239224 at 3.9403E-02 3.14E-03 3.02 -1.91 1.20E-01
4363 GNA1 1 40562 at 3.9403E-02 3.14E-03 -3.02 -1.91 -3.57E-01
4364 ATP6AP2 201443 s at 3.9415E-02 3.15E-03 -3.02 -1.91 -2.02E-01
4365 ALDH4A1 203722 at 3.9430E-02 3.15E-03 -3.02 -1.91 -1.65E-01
4366 231 1 11 at 3.9441 E-02 3.15E-03 3.02 -1.91 , 2.53E-01
4367 SHQ1 63009 at 3.9485E-02 3.15E-03 3.02 -1.91 2.18E-01
4368 CADM2 2351 18 at 3.9485E-02 3.15E-03 3.02 -1.91 8.54E-02
4369 PYG02 239666 at 3.9519E-02 3.16E-03 3.02 -1.91 1.93E-01
4370 1569962 at 3.9526E-02 3.16E-03 3.02 -1.91 1.60E-01
4371 FOXA2 214312 at 3.9526E-02 3.16E-03 3.02 -1.91 1.58E-01
4372 LOC283663 230245 s at 3.9526E-02 3.16E-03 3.02 -1.91 8.31 E-01
4373 ARF1 244504 x at 3.9530E-02 3.16E-03 3.02 -1.91 1.60E-01
4374 C21orf62 220543 at 3.9530E-02 3.16E-03 3.02 -1.91 1.10E-01
4375 ZNF827 243617 at 3.9538E-02 3.16E-03 3.02 -1.91 1.56E-01
4376 ADRB3 217303 s at 3.9540E-02 3.16E-03 3.02 -1.91 1.35E-01
4377 WDFY3 212606 at 3.9561 E-02 3.17E-03 -3.01 -1.91 -4.06E-01
4378 1559020 a at 3.9582E-02 3.17E-03 3.01 -1.91 2.44E-01
4379 BCL6 215990 s at 3.9582E-02 3.17E-03 -3.01 -1.91 -3.61 E-01
4380 EIF4G2 1557964 at 3.9582E-02 3.17E-03 3.01 -1.91 1.64E-01
4381 SOX1 230982 at 3.9658E-02 3.18E-03 3.01 -1.91 1.83E-01
4382 CYP2B7P1// 206754 s at 3.9658E-02 3.18E-03 3.01 -1.91 1.79E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
/CYP2B6
4383 240222 at 3.9658E-02 3.18E-03 3.01 -1.92 1.14E-01
4384 VCAN 221731 x at 3.9658E-02 3.18E-03 -3.01 -1.92 -1.24E+00
4385 CDK2AP2 203252 at 3.9698E-02 3.18E-03 -3.01 -1.92 -4.02E-01
4386 ANAPC4 226917 s at 3.9700E-02 3.18E-03 3.01 -1.92 3.54E-01
4387 CCDC7 1553215 s at 3.9703E-02 3.19E-03 3.01 -1.92 1.89E-01
4388 237694 at 3.9722E-02 3.19E-03 3.01 -1.92 1.42E-01
4389 ATP2A2 209186 at 3.9780E-02 3.19E-03 -3.01 -1.92 -4.91 E-01
4390 S4A1 228599 at 3.9818E-02 3.20E-03 3.01 -1.92 8.60E-01
4391 TDRKH 223530 at 3.9835E-02 3.20E-03 -3.01 -1.92 -2.10E-01
4392 KCNRG 240288 at 3.9836E-02 3.20E-03 3.01 -1.92 9.79E-02
4393 GCHFR 204867 at 3.9836E-02 3.20E-03 3.01 -1.92 4.07E-01
4394 C11orf17 219953 s at 3.9836E-02 3.20E-03 -3.01 -1.92 -2.10E-01
4395 ACTN1 208636 at 3.9836E-02 3.20E-03 -3.01 -1.92 -3.81 E-01
4396 NACA 208635 x at 3.9836E-02 3.20E-03 3.01 -1.92 1.88E-01
4397 HMGCS1 205822 s at 3.9836E-02 3.20E-03 -3.01 -1.92 -2.03E-01
4398 iPW 241834 at 3.9836E-02 3.20E-03 3.01 -1.92 1.07E-01
4399 ACF1 232168 x at 3.9836E-02 3.21 E-03 3.01 -1.92 2.68E-01
4400 IL2 207849 at 3.9836E-02 3.21 E-03 3.01 -1.92 1.47E-01
4401 TEC 206301 at 3.9836E-02 3.21 E-03 3.01 -1.92 1.64E-01
4402 TNFSF12 205611 at 3.9855E-02 3.21 E-03 -3.01 -1.92 -2.50E-01
4403 1569672 at 3.9855E-02 3.21 E-03 3.01 -1.92 1.00E-01
4404 ITGA5 201389 at 3.9855E-02 3.21 E-03 -3.01 -1.92 -3.88E-01
4405 ANKRD16 229058 at 3.9900E-02 3.22E-03 -3.01 -1.93 -1.96E-01
4406 SSH1 221 53_at 3.9900E-02 3.22E-03 -3.01 -1.93 -2.43E-01
4407 236159 x at 3.9900E-02 3.22E-03 3.01 -1.93 1.95E-01
4408 TMEM30A 232591 s at 3.9900E-02 3.22E-03 -3.01 -1.93 -5.11 E-01
4409 PPIF 201490 s at 3.9918E-02 3.22E-03 -3.01 -1.93 -5.66E-01
4410 GNB4 225710 at 3.9918E-02 3.22E-03 -3.01 -1.93 -3.78E-01
4411 AK3L2///AK4 230630 at 3.9918E-02 3.22E-03 -3.01 -1.93 -1.44E-01
4412 236005 at 3.9918 E-02 3.22 E-03 3.01 -1.93 1.63E-01
4413 CECR6 224393 s at 3.9928E-02 3.22E-03 -3.01 -1.93 -2.02E-01
4414 C6orf105 229070_at 3.9931 E-02 3.22E-03 3.01 -1.93 6.42E-01
4415 FU37035 1560714 at 3.9931E-02 3.22E-03 3.01 -1.93 8.82E-02
4416 AGPAT4 219693 at 3.9952E-02 3.23E-03 -3.01 -1.93 -2.26E-01
4417 1564378 a at 3.9960E-02 3.23E-03 3.01 -1.93 2.11 E-01
4418 T1 E 212859 x at 3.9960E-02 3.23E-03 -3.01 -1.93 -6.86E-01
4419 NUBP2 218227 at 3.9963E-02 3.23E-03 3.01 -1.93 2.50E-01
4420 CREBL2 201989 s at 3.9963E-02 3.23E-03 -3.01 -1.93 -2.39E-01
4421 243272 at 4.0013E-02 3.24E-03 3.01 -1.93 1.68E-01
4422 TACC1 200911 s at 4.0013E-02 3.24E-03 -3.01 -1.93 -2.86E-01
4423 ZNF182 235810 at 4.0013E-02 3.24E-03 -3.01 -1.93 -2.74E-01
4424 KIF13B 202962 at 4.0013E-02 3.24E-03 -3.01 -1.93 -2.88E-01
4425 BLAC1 1554170 a at 4.0013E-02 3.24E-03 3.01 -1.93 1.43E-01
4426 GPR107 220265 at 4.0081 E-02 3.25E-03 3.01 -1.93 1.16E-01
4427 IDH3B 210014 x at 4.0081 E-02 3.25E-03 -3.01 -1.93 -3.11 E-01
4428 MAP4K5 211081 s at 4.0081 E-02 3.25E-03 -3.01 -1.93 -3.05E-01
4429 DENND1A 219763 at 4.0081 E-02 3.25E-03 -3.01 -1.93 -2.59E-01
4430 SLC30A8 1552985 at 4.0081 E-02 3.25E-03 3.01 -1.93 1.53E-01
4431 ATP10B 220920 at 4.0081 E-02 3.25E-03 3.01 -1.93 1.55E-01
4432 KD 6B 1556067 a at 4.0081 E-02 3.25E-03 3.01 -1.93 2.22E-01
4433 CARM1 212512 s at 4.0081 E-02 3.25E-03 -3.01 -1.93 -5.13E-01
4434 1560999 a at 4.0081 E-02 3.25E-03 3.01 -1.93 3.36E-01
4435 236611 at 4.0081 E-02 3.25E-03 3.01 -1.93 5.02E-01
4436 SPIN3 1554098 at 4.0081 E-02 3.25E-03 3.01 -1.93 1.29E-01
4437 FCGR2C///F 1565674_at 4.0081 E-02 3.25E-03 -3.01 -1.93 -2.35E-01 CGR2B///FC
GR2A
4438 EARS2 225993 at 4.0119E-02 3.26E-03 -3.01 -1.94 -1.76E-01
4439 ATP1 1B 1564064 a at 4.0119E-02 3.26E-03 -3.01 -1.94 -2.82E-01
4440 PG 2 223738 s at 4.0119E-02 3.26E-03 -3.01 -1.94 -2.18E-01
4441 235406 x at 4.0119E-02 3.26E-03 3.01 -1.94 2.78E-01
4442 TGOLN2 212040 at 4.0136E-02 3.26E-03 -3.01 -1.94 -6.55E-01
4443 E2F1 204947 at 4.0137E-02 3.26E-03 3.01 -1.94 1.99E-01
4444 C2R 217434 at 4.0165E-02 3.26E-03 3.00 -1.94 9.68E-02
4445 227682 at 4.0173E-02 3.27E-03 -3.00 -1.94 -3.23E-01
4446 PBX1 212151 at 4.0173E-02 3.27E-03 -3.00 -1.94 -4.23E-01
4447 GNB1 200746 s at 4.0173E-02 3.27E-03 -3.00 -1 .94 -2.60E-01
4448 NHP2L1 230443 at 4.0173E-02 3.27E-03 3.00 -1.94 3.47E-01
Wo. Gene* Probe ID** Adj. p value P value f B Log FC
4449 233713_at 4.0173E-02 3.27E-03 3.00 -1.94 2.27E-01
4450 DYNC1 LI2 203590 at 4.0193E-02 3.27E-03 -3.00 -1.94 -4.19E-01
4451 LOC 100288 225653_at 4.0219E-02 3.27E-03 -3.00 -1.94 -2.02E-01 263///LOC64
4617
4452 ZNF227 217403 s at 4.0258E-02 3.28E-03 -3.00 -1.94 -3.38E-01
4453 LOC100130 244744_at 4.0262E-02 3.28E-03 3.00 -1.94 1.61E-01 502
4454 NADK 208917 x at 4.0262E-02 3.28E-03 -3.00 -1.94 -2.43E-01
4455 QKI 1555154 a at 4.0299E-02 3.28E-03 -3.00 -1.94 -3.61 E-01
4456 CA12 204508 s at 4.0303E-02 3.29E-03 -3.00 -1.94 -5.74E-01
4457 GRB10 209409 at 4.0303E-02 3.29E-03 -3.00 -1.94 -3.58E-01
4458 DBN1 202806 at 4.0303E-02 3.29E-03 -3.00 -1.94 -3.49E-01
4459 1569885 at 4.0389E-02 3.29E-03 3.00 -1.95 1.44E-01
4460 1559287 at 4.041 OE-02 3.30E-03 3.00 -1.95 1.37E-01
4461 HSPB11 215691 x at 4.0431 E-02 3.3DE-03 3.00 -1.95 4.00E-01
4462 CDCA7 230060 at 4.0485E-02 3.30E-03 3.00 -1.95 2.30E-01
4463 GPR108 225058 at 4.0485E-02 3.31 E-03 -3.00 -1.95 -3.20E-01
4464 KSR1 213769 at 4.0485E-02 3.31 E-03 3.00 -1.95 1.68E-01
4465 POLR2A 217415 at 4.0485E-02 3.31 E-03 3.00 -1.95 1.02E-01
4466 RPL23 200888 s at 4.0517E-02 3.31 E-03 3.00 -1.95 2.19E-01
4467 RAB3C 241977 s at 4.0517E-02 3.31 E-03 3.00 -1.95 1.11E-01
4468 234789 at 4.0517E-02 3.31 E-03 3.00 -1.95 9.09E-02
4469 CBY3 238138 at 4.0517E-02 3.31 E-03 3.00 -1.95 1.24E-01
4470 CDK5RAP2 243153 at 4.0526E-02 3.31 E-03 3.00 -1.95 1.47E-01
4471 SNF8 218391_at 4.0627E-02 3.32E-03 -3.00 -1.95 -3.66E-01
4472 LOC100129 236560_at 4.0627E-02 3.32E-03 3.00 -1.95 1.35E-01 884
4473 ATG12 213026_at 4.0636E-02 3.32E-03 3.00 -1.95 3.13E-01
4474 BPIL2 1555773 at 4.0647E-02 3.33E-03 3.00 -1.95 1.40E-01
4475 RGS10 204319 s_at 4.0650E-02 3.33E-03 3.00 -1.95 4.04E-01
4476 G6PC3 44654 at 4.0654E-02 3.33E-03 -3.00 -1.96 -3.07E-01
4477 GOLIM4 204324 s at 4.0654E-02 3.33E-03 -3.00 -1.96 -5.11 E-01
4478 ALOX5 204446 s at 4.0678E-02 3.33E-03 -3.00 -1.96 -5.34E-01
4479 HAB1 216875 x at 4.0743E-02 3.34E-03 3.00 -1.96 2.09E-01
4480 TMEM14B 223133 at 4.0743E-02 3.34E-03 3.00 -1.96 4.80E-01
4481 215612 at 4.0743E-02 3.34E-03 3.00 -1.96 2.12E-01
4482 KPNA5 229317 at 4.0760E-02 3.34E-03 3.00 -1.96 3.75E-01
4483 241681 at 4.0760E-02 3.34E-03 3.00 -1.96 6.92E-01
4484 CHMP4C 226803 at 4.0762E-02 3.34E-03 -3.00 -1.96 -1.82E-01
4485 234582 at 4.0762E-02 3.35E-03 3.00 -1.96 1.19E-01
4486 MAPK7 35617 at 4.0762E-02 3.35E-03 -3.00 -1.96 -2.08E-01
4487 ANKFY1 224900 at 4.0762E-02 3.35E-03 -3.00 -1.96 -3.55E-01
4488 244331 at 4.0762E-02 3.35E-03 3.00 -1.96 1.17E-01
4489 TIMELESS 215455 at 4.0762E-02 3.35E-03 3.00 -1.96 1.51 E-01
4490 1568660 a at 4.0762E-02 3.35E-03 3.00 -1.96 9.37E-02
4491 TFIP11 202750 s at 4.0762E-02 3.35E-03 -3.00 -1.96 -2.86E-01
4492 PIWIL1 214868 at 4.0762E-02 3.35E-03 3.00 -1.96 1.08E-01
4493 GALC 211810 s at 4.0762E-02 3.35E-03 -3.00 -1.96 -2.11 E-01
4494 SEC31A 210616 s at 4.0762 E-02 3.35E-03 -3.00 -1.96 -4.46E-01
4495 1562082 at 4.0762E-02 3.35E-03 3.00 -1.96 9.77E-02
4496 TAF7L 220325 at 4.0769E-02 3.35E-03 3.00 -1.96 1.26E-01
4497 NAV3 204823 at 4.0769E-02 3.35E-03 -3.00 -1.96 -3.30E-01
4498 ACTBP9 217211 at 4.0771 E-02 3.35E-03 -3.00 -1.96 -3.14E-01
4499 227368 at 4.0771 E-02 3.36E-03 3.00 -1.96 3.09E-01
4500 S AP1 205790 at 4.0771 E-02 3.36E-03 3.00 -1.96 3.80E-01
4501 HGSNAT 218017 s at 4.0771 E-02 3.36 E-03 -3.00 -1.96 -5.30E-01
4502 NDUFA4L2 218484 at 4.0771 E-02 3.36E-03 -3.00 -1.96 -2.65E-01
4503 TMEM170A 230414 s at 4.0840E-02 3.36E-03 2.99 -1.96 1.38E-01
4504 EIF3B 208688 x at 4.0840E-02 3.36E-03 -2.99 -1.96 -3.54E-01
4505 1562715 at 4.0842E-02 3.37E-03 2.99 -1.96 8.63E-02
4506 N AP 223439 at 4.0860E-02 3.37E-03 -2.99 -1.97 -3.05E-01
4507 RALGPS1 210552 s at 4.0860E-02 3.37E-03 2.99 -1.97 1.18E-01
4508 ARHGAP26 226576 at 4.0860E-02 3.37E-03 -2.99 -1.97 -4.02E-01
4509 FKBP5 224856 at 4.0877E-02 3.37E-03 -2.99 -1.97 -6.20E-01
4510 FAM166B 229941 at 4.0914E-02 3.37E-03 2.99 -1.97 1.39E-01
4511 SAMHD1 1559883 s at 4.0929E-02 3.38E-03 -2.99 -1.97 -6.10E-01
4512 1563217 at 4.0942E-02 3.38E-03 2.99 -1.97 1.48E-01
4513 LOC100288 234388 at 4.0971 E-02 3.38E-03 2.99 -1.97 1.80E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
702///ACTR
3P1///RPL4
P1// TRA®//
/SALL2
4514 243990 at 4.0971 E-02 3.38E-03 2.99 -1.97 1.82E-01
4515 235207 at 4.0972E-02 3.38E-03 2.99 -1.97 3.40E-01
4516 1559723 s at 4.1020E-02 3.39E-03 2.99 -1.97 1.67E-01
4517 PSMB1 200876 s at 4.1020E-02 3.39E-03 -2.99 -1.97 -3.83E-01
4518 NCAM1 229799 s at 4.1020E-02 3.39E-03 2.99 -1.97 1.20E-01
4519 GNAS 214548 x at 4.1020E-02 3.39E-03 -2.99 -1.97 -4.88E-01
4520 C11orf57 222588 s at 4.1020E-02 3.39E-03 -2.99 -1.97 -2.69E-01
4521 UBC///UBB// 200017_at 4.1020E-02 3.39E-03 2.99 -1.97 2.01E-01 /RPS27A
4522 MAPK1 1552264 a at 4.1020E-02 3.39E-03 -2.99 -1.97 -3.17E-01
4523 RBM15 228455 at 4.1046E-02 3.40E-03 2.99 -1.97 3.75E-01
4524 PTGR1 228824 s at 4.1052E-02 3.40E-03 -2.99 -1.97 -4.08E-01
4525 215335 at 4.1052E-02 3.40E-03 2.99 -1.97 1.21E-01
4526 TRIM14 211044 at 4.1052E-02 3.40E-03 2.99 -1.97 1.47E-01
4527 PSMD2 200830_at 4.1052E-02 3.40E-03 -2.99 -1.97 -2.34E-01
4528 FKBP1A 200709_at 4.1052E-02 3.40E-03 -2.99 -1.97 -4.44E-01
4529 UBE2F 225783 at 4.1078E-02 3.40E-03 -2.99 -1.97 -2.34E-01
4530 IDH3G 202471 s at 4.1087E-02 3.40E-03 -2.99 -1.97 -4.57E-01
4531 C15orf51 231318 at 4.1110E-02 3.41 E-03 2.99 -1.98 1.21 E-01
4532 1562907 at 4.1110E-02 3.41 E-03 2.99 -1.98 1.29E-01
4533 1565915 at 4.1126E-02 3.41 E-03 2.99 -1.98 9.44E-02
4534 LOC100133 20611 1_at 4.1130E-02 3.41 E-03 -2.99 -1.98 -5.09E-01
811///LOC10
0133661///Z
NF749///RN
ASE2///HLA-
DRB5///HLA
DRB4///HLA
DRB3///HLA
DRB2///HLA
-DRB1
4535 RNF17 224384 s at 4.1212E-02 3.42E-03 2.99 -1.98 1.25E-01
4536 EPRS 200843 s at 4.1212E-02 3.42E-03 -2.99 -1.98 -2.53E-01
4537 ACTB 200801 x at 4.1231 E-02 3.42E-03 -2.99 -1.98 -4.11 E-01
4538 LOC100130 216387_x_at 4.1261 E-02 3.42E-03 2.99 -1.98 1.95E-01 233///LOC39
9804
4539 LOC645513 242305 at 4.1276E-02 3.43E-03 2.99 -1.98 2.58E-01
4540 243086 at 4.1280E-02 3.43E-03 2.99 -1.98 1.39E-01
4541 MLLT10 205408 at 4.1290E-02 3.43E-03 -2.99 -1.98 -2.51 E-01
4542 JPH3 243679 at 4.1300E-02 3.43E-03 2.99 -1.98 1.65E-01
4543 SLFN11 226743 at 4.1302E-02 3.43E-03 -2.99 -1.98 -2.80E-01
4544 FARP1 201910 at 4.1397E-02 3.44E-03 -2.99 -1.98 -2.95E-01
4545 SRXN1 225252 at 4.1437E-02 3.44E-03 -2.99 -1.99 -3.32E-01
4546 PACS2 212778 at 4.1437E-02 3.45E-03 -2.99 -1.99 -3.43E-01
4547 LASP1 200618 at 4.1459E-02 3.45E-03 -2.99 -1.99 -4.62E-01
4548 KPNB1 217027 x at 4.1459E-02 3.45E-03 -2.99 -1.99 -3.21 E-01
4549 243996 at 4.1484E-02 3.45E-03 2.99 -1.99 1.82E-01
4550 KPNB1 208975 s at 4.1484E-02 3.45E-03 -2.99 -1.99 -3.90E-01
4551 MAPK1 224621 at 4.1495E-02 3.45E-03 -2.99 -1.99 -2.37E-01
4552 SS18 216684 s at 4.1521 E-02 3.46E-03 -2.99 -1.99 -1.54E-01
4553 215502 at 4.1538E-02 3.46E-03 2.99 -1.99 1.87E-01
4554 BRE 205550 s at 4.1538E-02 3.46E-03 -2.99 -1.99 -3.36E-01
4555 231340 at 4.1562E-02 3.46E-03 2.99 -1.99 1.60E-01
4556 PTPRC 1552480 s at 4.1562E-02 3.46E-03 2.99 -1.99 3.64E-01
4557 TRUB1 241606 s at 4.1562E-02 3.46E-03 2.99 -1.99 1.93E-01
4558 KRAS 204010 s at 4.1562E-02 3.46E-03 2.99 -1.99 2.06E-01
4559 242926 at 4.1586E-02 3.47E-03 2.98 -1.99 1.58E-01
4560 DBF4 204244 s at 4.1586E-02 3.47E-03 2.98 -1.99 3.83E-01
4561 NFKB2 207535 s at 4.1586E-02 3.47E-03 -2.98 -1.99 -2.91 E-01
4562 230034 x at 4.1586E-02 3.47E-03 2.98 -1.99 1.61 E-01
4563 FAM190B 1554132 a at 4.1589E-02 3.47 E-03 -2.98 -1.99 -4.29E-01
4564 241482 at 4.1589E-02 3.47E-03 2.98 -1.99 8.67E-02
No. Gene* Probe ID** Adj. p value P value ί B Log FC
4565 C9orf93 1558082 at 4.1589E-02 3.47E-03 2.98 -1.99 1.13E-01
4566 SPPL3 1566897 at 4.1589E-02 3.47E-03 2.98 -1.99 1.95E-01
4567 1558822 at 4.1589E-02 3.47E-03 2.98 -1.99 2.73E-01
4568 SMA CC2 1561973 at 4.1589E-02 3.47E-03 2.98 -1.99 2.00E-01
4569 2401 18 at 4.1590E-02 3.48E-03 -2.98 -1.99 -3.68E-01
4570 239065 at 4.1593E-02 3.48E-03 2.98 -1.99 1.09E-01
4571 YAP1 224895 at 4.1593E-02 3.48E-03 -2.98 -1.99 -4.80E-01
4572 ZNF330 213760 s at 4.1593E-02 3.48E-03 2.98 -1.99 2.34E-01
4573 LYRM5 225469 at 4.1593E-02 3.48E-03 2.98 -1.99 4.16E-01
4574 TR1M66 213748 at 4.1593E-02 3.48E-03 -2.98 -1.99 -1.53E-01
4575 1566195 at 4.1593E-02 3.48E-03 2.98 -1.99 1.17E-01
4576 NDUFB10 228301 x at 4.1603E-02 3.48E-03 2.98 -1.99 2.06E-01
4577 LOC100129 1559618_at 4.1613E-02 3.48E-03 2.98 -1.99 2.95E-01 447
4578 GATAD2B 238076_at 4.1613E-02 3.48 E-03 2.98 -2.00 2.48E-01
4579 1566902 at 4.1668E-02 3.49E-03 2.98 -2.00 1.02E-01
4580 239823 at 4.1745E-02 3.50E-03 2.98 -2.00 3.41 E-01
4581 ZNF474 1556907 at 4.1750E-02 3.50E-03 2.98 -2.00 1.00E-01
4582 1CT1 204868 at 4.1790E-02 3.50E-03 2.98 -2.00 3.70E-01
4583 DENR 238982 at 4.1817E-02 3.51 E-03 2.98 -2.00 1.78E-01
4584 UBOX5 204598 at 4.1852E-02 3.51 E-03 2.98 -2.00 1.48E-01
4585 230476 at 4.1852E-02 3.51 E-03 2.98 -2.00 1.38E-01
4586 PLXND1 38671 at 4.1854E-02 3.51 E-03 -2.98 -2.00 -4.59E-01
4587 ST13 208666 s at 4.1854E-02 3.51 E-03 -2.98 -2.00 -3.85E-01
4588 TCF3 216645 at 4.1883E-02 3.51 E-03 2.98 -2.00 1.75E-01
4589 228115 at 4.1886E-02 3.52E-03 -2.98 -2.00 -1.06E-01
4590 TTC3 1569472 s at 4.1886E-02 3.52E-03 -2.98 -2.00 -2.48E-01
4591 1565760 at 4.1886E-02 3.52E-03 2.98 -2.00 9.60E-02
4592 229844 at 4.1886E-02 3.52E-03 2.98 -2.00 3.53E-01
4593 226347 at 4.1886E-02 3.52E-03 -2.98 -2.00 -2.91 E-01
4594 FAM189B 203550 s at 4.1886E-02 3.52E-03 -2.98 -2.00 -1.52E-01
4595 237148 at 4.1917E-02 3.53 E-03 2.98 -2.01 9.49E-02
4596 CYP26B1 219825 at 4.1917E-02 3.53E-03 -2.98 -2.01 -3.73E-01
4597 PRND 223813 at 4.1917E-02 3.53E-03 2.98 -2.01 1.30E-01
4598 C1 orf116 228865 at 4.1917E-02 3.53E-03 2.98 -2.01 1.28E-01
4599 PHKB 242248 at 4.1917E-02 3.53E-03 2.98 -2.01 1.30E-01
4600 VPS25 224608 s at 4.1917E-02 3.53E-03 -2.98 -2.01 -3.96E-01
4601 1568639 a at 4.1917E-02 3.53E-03 -2.98 -2.01 -1.43E-01
4602 ALDH3B1 205640 at 4.1917E-02 3.53E-03 -2.98 -2.01 -3.06E-01
4603 GRLF1 229397 s at 4.1917E-02 3.53E-03 2.98 -2.01 1.75E-01
4604 HLA-E 200905 x at 4.1932E-02 3.53E-03 -2.98 -2.01 -3.24E-01
4605 UGP2 205480 s at 4.1932E-02 3.53E-03 -2.98 -2.01 -3.57E-01
4606 ZFP106 217781 s at 4.1932E-02 3.53E-03 -2.98 -2.01 -3.02E-01
4607 USP10 209136 s at 4.1950E-02 3.53E-03 -2.98 -2.01 -3.83E-01
4608 DNAJC7 1556053 at 4.1964E-02 3.54E-03 2.98 -2.01 2.85E-01
4609 C21orf57 227421 at 4.1964E-02 3.54E-03 2.98 -2.01 3.56E-01
4610 232431 at 4.1974E-02 3.54E-03 2.98 -2.01 5.42E-01
4611 IGFBP5 203424 s at 4.1988E-02 3.54E-03 -2.98 -2.01 -4.67E-01
4612 LEPROT///L 202377_at 4.2017E-02 3.54E-03 -2.98 -2.01 -4.44E-01 EPR
4613 C11orf75 219806 s at 4.2017E-02 3.55E-03 -2.98 -2.01 -3.76E-01
4614 234065 at 4.2078E-02 3.55E-03 2.98 -2.01 1.27E-01
4615 GNA1 1 213766 x at 4.2088E-02 3.55E-03 -2.98 -2.01 -3.61 E-01
4616 TNFRSF13 1552892_at 4.2096E-02 3.55E-03 2.98 -2.01 2.89E-01 C
4617 SLC37A4 217289 s at 4.2096E-02 3.55E-03 -2.98 -2.01 -1.87E-01
4618 FNDC3B 218618 s at 4.2097E-02 3.56E-03 -2.98 -2.01 -6.94E-01
4619 TADA3 215273 s at 4.2097E-02 3.56E-03 -2.98 -2.01 -3.60E-01
4620 F5 231029 at 4.2097E-02 3.56E-03 2.98 -2.01 2.03E-01
4621 TMEM27 223784 at 4.2116E-02 3.56E-03 2.98 -2.01 8.47E-02
4622 240825 at 4.2116E-02 3.56E-03 2.98 -2.01 1.19E-01
4623 PDZK1 205380 at 4.2116E-02 3.56E-03 2.98 -2.01 1.01 E-01
4624 MDM4 225740 x at 4.2143E-02 3.56E-03 2.98 -2.01 3.48E-01
4625 LOC729143/ 214694_at 4.2178E-02 3.57E-03 -2.98 -2.02 -1.40E-01 //MPR1P
4626 NUCB1 200649 at 4.2178E-02 3.57E-03 -2.98 -2.02 -5.50E-01
4627 ITPKB 232526 at 4.2178E-02 3.57E-03 2.98 -2.02 1.50E-01
4628 ALDH2 201425 at 4.2178E-02 3.57E-03 -2.98 -2.02 -4.81 E-01
4629 SPTAN1 214925 s at 4.2178E-02 3.57E-03 2.98 -2.02 2.86E-01
No. Gene* Probe ID" Adj. p value P value ί B Log FC
4630 CROCC 216419 at 4.2246E-02 3.58E-03 2.97 -2.02 1.91E-01
4631 CNR1 207940 x at 4.2259E-02 3.58E-03 2.97 -2.02 1.31 E-01
4632 NPY6R 210444 at 4.2264E-02 3.58E-03 2.97 -2.02 1.64E-01
4633 LS 6 205036 at 4.2328E-02 3.59E-03 2.97 -2.02 4.76E-01
4634 USP22 200083 at 4.2328E-02 3.59E-03 -2.97 -2.02 -3.37E-01
4635 EHD1 209037 s at 4.2328E-02 3.59E-03 -2.97 -2.02 -4.26E-01
4636 ZNF789 235231 at 4.2344E-02 3.59E-03 2.97 -2.02 3.16E-01
4637 ANKS1B 227440 at 4.2352E-02 3.59E-03 2.97 -2.02 2.79E-01
4638 KCNC4 235467 s at 4.2352E-02 3.59E-03 -2.97 -2.02 -2.01 E-01
4639 C14orf181 229054 at 4.2352E-02 3.59E-03 2.97 -2.02 2.78E-01
4640 APLN 244166_at 4.2352E-02 3.59E-03 2.97 -2.02 3.63E-01
4641 243137 at 4.2352E-02 3.60E-03 2.97 -2.02 1.10E-01
4642 236581 at 4.2352E-02 3.60E-03 2.97 -2.02 1.90E-01
4643 237008 at 4.2352E-02 3.60E-03 2.97 -2.02 1.51 E-01
4644 231419 at 4.2368E-02 3.60E-03 2.97 -2.02 1.73E-01
4645 TAGLN 205547_s_at 4.2368E-02 3.60E-03 -2.97 -2.02 -7.66E-01
4646 240139 at 4.2389E-02 3.60E-03 2.97 -2.02 2.28E-01
4647 LOC388588 230840 at 4.2404E-02 3.60E-03 2.97 -2.02 1.60E-01
4648 TEX28 207364 at 4.2407E-02 3.61 E-03 2.97 -2.02 1.43E-01
4649 XPNPEP3 228820 at 4.2407E-02 3.61 E-03 2.97 -2.03 2.98E-01
4650 215858_at 4.2407E-02 3.61 E-03 2.97 -2.03 1.59E-01
4651 238835_at 4.2407E-02 3.61 E-03 -2.97 -2.03 -2.42E-01
4652 SLA 203760 s at 4.2443E-02 3.61 E-03 -2.97 -2.03 -3.53E-01
4653 LYCD 218869 at 4.2443E-02 3.61 E-03 -2.97 -2.03 -2.05E-01
4654 BACE2 222446 s at 4.2443E-02 3.61 E-03 -2.97 -2.03 -4.42E-01
4655 L BRD1 232980 at 4.2443E-02 3.61 E-03 2.97 -2.03 1.29E-01
4656 RPS19 213414 s at 4.2443E-02 3.61 E-03 2.97 -2.03 1.24E-01
4657 POLR2F 232643 at 4.2443E-02 3.62E-03 2.97 -2.03 1.75E-01
4658 241316 at 4.2456E-02 3.62E-03 2.97 -2.03 1.08E-01
4659 HDAC1 201209 at 4.2456E-02 3.62E-03 2.97 -2.03 2.23E-01
4660 LSM1 203534 at 4.2468E-02 3.62E-03 2.97 -2.03 2.93E-01
4661 SOX4 1567906 at 4.2517E-02 3.62E-03 2.97 -2.03 1.97E-01
4662 SETD5 244691 at 4.2517E-02 3.63E-03 2.97 -2.03 1.26E-01
4663 ANGPT2 236034 at 4.25 7E-02 3.63E-03 -2.97 -2.03 -2.48E-01
4664 UNC5B 213100 at 4.2517E-02 3.63E-03 -2.97 -2.03 -2.39E-01
4665 TUS2 1554755 a at 4.2517E-02 3.63E-03 2.97 -2.03 1.33E-01
4666 239731 at 4.2517E-02 3.63E-03 2.97 -2.03 2.31 E-01
4667 242846 at 4.2540E-02 3.63E-03 2.97 -2.03 1.24E-01
4668 TCEB3 213604 at 4.2550E-02 3.63E-03 -2.97 -2.03 -2.14E-01
4669 RPS15A 200781 s at 4.2556E-02 3.63E-03 2.97 -2.03 1.93E-01
4670 234745 at 4.2574E-02 3.64E-03 2.97 -2.03 1.18E-01
4671 KCNJ2 206765 at 4.2600E-02 3.64E-03 -2.97 -2.03 -7.71 E-01
4672 241178 at 4.2600E-02 3.64E-03 2.97 -2.03 1.28E-01
4673 NT5C1A 224529 s at 4.2612E-02 3.64E-03 2.97 -2.03 1.48E-01
4674 ARHGDIA 201167 x at 4.2651 E-02 3.65E-03 -2.97 -2.03 -1.92E-01
4675 UN 228357 at 4.2693E-02 3.65E-03 2.97 -2.04 4.43E-01
4676 C11orf24 52164 at 4.2702E-02 3.65E-03 -2.97 -2.04 -3.58E-01
4677 UPK3B 206658 at 4.2702E-02 3.65E-03 2.97 -2.04 1.63E-01
4678 SLC39A14 212110 at 4.2702E-02 3.65E-03 -2.97 -2.04 -5.80E-01
4679 LACTB 1552485 at 4.2702E-02 3.65E-03 -2.97 -2.04 -3.76E-01
4680 237632 at 4.2702E-02 3.66E-03 2.97 -2.04 2.08E-01
4681 DNAJA4 1554334 a at 4.2703E-02 3.66E-03 -2.97 -2.04 -2.92E-01
4682 STT3B 231285 at 4.2755E-02 3.66E-03 2.97 -2.04 1.17E-01
4683 RPL35 200002 at 4.2779E-02 3.66E-03 2.97 -2.04 2.63E-01
4684 RANGAP1 212125 at 4.2792E-02 3.67E-03 -2.97 -2.04 -3.32E-01
4685 FPR1 205119 s at 4.2871 E-02 3.67E-03 -2.97 -2.04 -4.50E-01
4686 1563339 at 4.2872E-02 3.67E-03 2.97 -2.04 1.05E-01
4687 ZNF827 231902 at 4.2875E-02 3.68E-03 2.97 -2.04 1.27E-01
4688 HN T 204111 at 4.2909E-02 3.68E-03 -2.97 -2.04 -1.95E-01
4689 ACTN4 200601 at 4.2925E-02 3.68E-03 -2.97 -2.04 -4.63E-01
4690 TUBB 212320 at 4.2946E-02 3.68E-03 -2.96 -2.04 -4.22E-01
4691 CCDC33 220908 at 4.2948E-02 3.68E-03 -2.96 -2.04 -1.34E-01
4692 P L 206503 x at 4.2955E-02 3.69E-03 -2.96 -2.04 -2.59E-01
4693 239234 at 4.2959E-02 3.69E-03 2.96 -2.04 2.84E-01
4694 C4orf46///T 201812_s_at 4.3054E-02 3.70E-03 2.96 -2.05 2.96E-01 O 7
4695 RPL12P11/// 216354_at 4.3065E-02 3.70E-03 2.96 -2.05 2.14E-01 CHD6
4696 1556103 at 4.3065E-02 3.70E-03 2.96 -2.05 2.55E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
4697 1569713 at 4.3067E-02 3.70E-03 2.96 -2.05 1.46E-01
4698 SFXN3 1559993 at 4.3076E-02 3.70E-03 2.96 -2.05 2.43E-01
4699 ELTD1 219134 at 4.3076E-02 3.70E-03 -2.96 -2.05 -4.65E-01
4700 FGD4 227948 at 4.3076E-02 3.70E-03 -2.96 -2.05 -3.52E-01
4701 ZFP41 227902 at 4.3079E-02 3.70E-03 2.96 -2.05 1.85E-01
4702 PCIF1 222044 at 4.3084E-02 3.71 E-03 2.96 -2.05 4.99E-01
4703 GALNTL4 1554079 at 4.3110E-02 3.71 E-03 -2.96 -2.05 -2.34E-01
4704 ERGIC1 223847 s at 4.3121 E-02 3.71 E-03 -2.96 -2.05 -2.25E-01
4705 1563224 at 4.3121 E-02 3.71 E-03 2.96 -2.05 1.29E-01
4706 BOLA2B///B 209836_x_at 4.3142E-02 3.71 E-03 2.96 -2.05 4.41 E-01 OLA2
4707 MAP2K3 215498 s at 4.3142E-02 3.71 E-03 -2.96 -2.05 -3.32E-01
4708 ABCF2 207622 s at 4.3189E-02 3.72E-03 -2.96 -2.05 -4.95E-01
4709 1557522 x at 4.3189E-02 3.72E-03 2.96 -2.05 2.31 E-01
4710 MY03B 1560788 at 4.3189E-02 3.72E-03 2.96 -2.05 1.06E-01
4711 227278 at 4.3189E-02 3.72E-03 -2.96 -2.05 -3.45E-01
4712 LOC 100128 220715_at 4.3189E-02 3.72E-03 2.96 -2.05 1.36E-01 612
4713 CRYZL1 226151 x at 4.3189E-02 3.72E-03 2.96 -2.05 3.02E-01
4714 MED25 215897_at 4.3189E-02 3.72E-03 2.96 -2.05 8.88E-02
4715 RAB43///ISY 223429_x_at 4.3224E-02 3.73E-03 -2.96 -2.05 -2.87E-01 1
4716 JAK1 1552610... a at 4.3266E-02 3.73E-03 -2.96 -2.05 -6.53E-01
4717 HCRT 207642 at 4.3266E-02 3.73E-03 2.96 -2.06 1.41 E-01
4718 AZI2 223846 at 4.3271 E-02 3.73E-03 2.96 -2.06 1.62E-01
4719 PTGFR 1555097 a at 4.3277E-02 3.74E-03 -2.96 -2.06 -1.70E-01
4720 ABHD2 225337 at 4.3323E-02 3.74E-03 -2.96 -2.06 -3.70E-01
4721 SLC39A13 1552295 a at 4.3332E-02 3.74E-03 -2.96 -2.06 -1.67E-01
4722 GPR137 43934 at 4.3339E-02 3.74E-03 -2.96 -2.06 -1.23E-01
4723 RGS22 223691_at 4.3347E-02 3.74E-03 2.96 -2.06 1.51 E-01
4724 CTSH 202295 s at 4.3348E-02 3.75E-03 -2.96 -2.06 -2.83E-01
4725 Sep-06 213666 at 4.3351 E-02 3.75E-03 2.96 -2.06 3.93E-01
4726 IL6ST 21 1000 s at 4.3352E-02 3.75E-03 -2.96 -2.06 -4.38E-01
4727 RFFL 1566171 at 4.3352E-02 3.75E-03 2.96 -2.06 1.46E-01
4728 H GN3 209377 s at 4.3352E-02 3.75E-03 2.96 -2.06 2.76E-01
4729 ZNF599 228093_at 4.3352E-02 3.75E-03 2.96 -2.06 2.17E-01
4730 230451_at 4.3352E-02 3.75E-03 2.96 -2.06 2.48E-01
4731 KCNS3 205968_at 4.3357E-02 3.75E-03 -2.96 -2.06 -1.79E-01
4732 FAM43B 1569256 a at 4.3404E-02 3.76E-03 2.96 -2.06 1.78E-01
4733 231332 at 4.3429E-02 3.76E-03 2.96 -2.06 2.32E-01
4734 1558640 a at 4.3429E-02 3.76E-03 2.96 -2.06 1.21E-01
4735 MTCP1 216862 s at 4.3429E-02 3.76E-03 2.96 -2.06 3.21 E-01
4736 MUC1 213693 s at 4.3429E-02 3.76E-03 -2.96 -2.06 -2.41 E-01
4737 BRCC3 229436 x at 4.3432E-02 3.76E-03 -2.96 -2.06 -2.29E-01
4738 236428 at 4.3453E-02 3.77E-03 2.96 -2.06 2.49E-01
4739 EPSTI1 235276 at 4.3453E-02 3.77E-03 2.96 -2.06 4.07E-01
4740 ATR 233288 at 4.3453E-02 3.77E-03 2.96 -2.06 1.25E-01
4741 LYAR 223413 s at 4.3454E-02 3.77E-03 -2.96 -2.06 -4.84E-01
4742 AP3M1 222517 at 4.3517E-02 3.77E-03 2.96 -2.06 1.81 E-01
4743 TUBG1 201714 at 4.3517E-02 3.78E-03 -2.96 -2.07 -3.72E-01
4744 STARD10 23891 1 at 4.3517E-02 3.78E-03 2.96 -2.07 1.84E-01
4745 ZNF519 1564190 x at 4.3517E-02 3.78E-03 2.96 -2.07 1.23E-01
4746 THRAP3 222440 s at 4.3527E-02 3.78E-03 -2.96 -2.07 -2.24E-01
4747 BTLA 236226 at 4.3535E-02 3.78E-03 2.96 -2.07 5.76E-01
4748 1563302 at 4.3535E-02 3.78E-03 2.96 -2.07 1.27E-01
4749 WASL 205810 s at 4.3535E-02 3.78E-03 2.96 -2.07 1.37E-01
4750 PPT1 200975 at 4.3564E-02 3.78E-03 -2.96 -2.07 -2.51 E-01
4751 RANBP9 243108 at 4.3607E-02 3.79E-03 2.96 -2.07 1.47E-01
4752 PARP4 202239 at 4.3634E-02 3.79E-03 -2.96 -2.07 -2.43E-01
4753 HLA-DRA 210982 s at 4.3646E-02 3.79E-03 -2.96 -2.07 -4.28E-01
4754 FNIP2 226460 at 4.3646E-02 3.80E-03 -2.96 -2.07 -5.05E-01
4755 PKDREJ 220548 at 4.3658E-02 3.80E-03 2.95 -2.07 1.54E-01
4756 INPP5D 233545 at 4.3658E-02 3.80E-03 2.95 -2.07 1.45E-01
4757 AIF 1 205512 s at 4.3658E-02 3.80E-03 -2.95 -2.07 -4.33E-01
4758 GARS 208693 s at 4.3658E-02 3.80E-03 -2.95 -2.07 -3.39E-01
4759 CC2D2B 243534 at 4.3687E-02 3.80E-03 2.95 -2.07 2.27E-01
4760 242607 at 4.3713E-02 3.81 E-03 2.95 -2.07 2.08E-01
4761 AP3K4 216199 s at 4.3727E-02 3.81 E-03 2.95 -2.07 3.37E-01
4762 SET 213048_s_at 4.3750E-02 3.81 E-03 -2.95 -2.07 -2.52E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
4763 PCDHGA3 216343 at 4.3758E-02 3.81 E-03 2.95 -2.07 1.18E-01
4764 TPBG 203476 at 4.3758E-02 3.81 E-03 -2.95 -2.07 -5.36E-01
4765 1570125 at 4.3758E-02 3.81 E-03 2.95 -2.07 1.13E-01
4766 RABEP1 231002 s at 4.3758E-02 3.82E-03 2.95 -2.07 1.85E-01
4767 NAV2 222598 s at 4.3758E-02 3.82E-03 2.95 -2.07 2.02E-01
4768 PSAP 200871 s at 4.3758E-02 3.82E-03 -2.95 -2.07 -3.41 E-01
4769 CAPN1 200752 s at 4.3758E-02 3.82E-03 -2.95 -2.07 -3.96E-01
4770 242467 at 4.3762E-02 3.82E-03 2.95 -2.07 4.18E-01
4771 242206 at 4.3766E-02 3.82E-03 2.95 -2.08 1.84E-01
4772 PLD3 201050 at 4.3766E-02 3.82E-03 -2.95 -2.08 -7.61 E-01
4773 WNT5A 231227 at 4.3766E-02 3.82E-03 -2.95 -2.08 -3.39E-01
4774 GALNT14 1560180 at 4.3804E-02 3.82E-03 2.95 -2.08 1.57E-01
4775 LIMA1 222457 s at 4.3846E-02 3.83E-03 -2.95 -2.08 -3.88E-01
4776 H1VEP1 1560485 at 4.3848E-02 3.83E-03 2.95 -2.08 1.81 E-01
4777 TSR1 218156 s at 4.3872E-02 3.83E-03 -2.95 -2.08 -3.66E-01
4778 PDXK 218018 at 4.3872E-02 3.83E-03 -2.95 -2.08 -3.03E-01
4779 SCN11A 210853 at 4.3875E-02 3.84E-03 2.95 -2.08 1.06E-01
4780 242233 at 4.3875E-02 3.84E-03 2.95 -2.08 3.54E-01
4781 BTBD7 1556000 s at 4.3875E-02 3.84E-03 -2.95 -2.08 -1.86E-01
4782 LOC100144 238241_at 4.3875E-02 3.84E-03 2.95 -2.08 1.57E-01 602
4783 ZNF678 242923_at 4.3877E-02 3.84E-03 2.95 -2.08 2.06E-01
4784 244719 at 4.3882E-02 3.84E-03 2.95 -2.08 1.25E-01
4785 ANKHD1///E 219081_at 4.3883E-02 3.84E-03 -2.95 -2.08 -3.46E-01 1F4EBP3
4786 FEZ2 215000 s at 4.3883E-02 3.84E-03 -2.95 -2.08 -2.20E-01
4787 NAMPT 217738 at 4.3883E-02 3.84E-03 -2.95 -2.08 -3.96E-01
4788 C1TED2 207980 s at 4.3883E-02 3.84E-03 -2.95 -2.08 -5.64E-01
4789 NUCKS1 226880 at 4.3883E-02 3.84E-03 -2.95 -2.08 -3.18E-01
4790 1562456 at 4.3883E-02 3.85E-03 2.95 -2.08 1.48E-01
4791 UBE2N 201524 x at 4.3883E-02 3.85E-03 2.95 -2.08 2.19E-01
4792 ARHGAP29 1554736 at 4.3901 E-02 3.85E-03 2.95 -2.08 1.25E-01
4793 240215 at 4.3911 E-02 3.85E-03 2.95 -2.08 1.77E-01
4794 PGAP1 220576 at 4.3971 E-02 3.86E-03 2.95 -2.08 2.02E-01
4795 RHOG 203175 at 4.3978E-02 3.86E-03 -2.95 -2.08 -4.66E-01
4796 240621 at 4.3985E-02 3.86E-03 2.95 -2.08 2.33E-01
4797 CCDC88A 221078_s_at 4.3985E-02 3.86E-03 -2.95 -2.08 -2.77E-01
4798 ENG 201808_s_at 4.3986E-02 3.86E-03 -2.95 -2.08 -2.25E-01
4799 ANKRD10 223251 s at 4.3986E-02 3.86E-03 2.95 -2.08 3.94E-01
4800 ADD1 208030 s at 4.3996E-02 3.86E-03 -2.95 -2.08 -3.54E-01
4801 229155 at 4.4005E-02 3.86E-03 2.95 -2.09 1.21 E-01
4802 ERAL1 212087 s at 4.4005E-02 3.86E-03 -2.95 -2.09 -2.44E-01
4803 BAIAP3 216356 x at 4.4018E-02 3.87E-03 2.95 -2.09 1.56E-01
4804 DKFZP547J 1566624_at 4.4061 E-02 3.87E-03 2.95 -2.09 8.25E-02 0410
4805 CL1P3 235243 at 4.4061 E-02 3.87E-03 2.95 -2.09 1.37E-01
4806 AOX1 205083 at 4.4061 E-02 3.87E-03 -2.95 -2.09 -5.44E-01
4807 TMEM14B/// 223105_s_at 4.4061 E-02 3.87E-03 2.95 -2.09 2.85E-01 TMEM14C
4808 RANBP6 213019 at 4.4061 E-02 3.88E-03 2.95 -2.09 3.04E-01
4809 XAGE2B// X 229469_at 4.4061 E-02 3.88E-03 2.95 -2.09 1.53E-01 AGE2
4810 1557738 at 4.4061 E-02 3.88E-03 2.95 -2.09 1.25E-01
481 1 1569608 x at 4.4061 E-02 3.88E-03 2.95 -2.09 2.67E-01
4812 ARAP1 34206 at 4.4061 E-02 3.88E-03 -2.95 -2.09 -3.92E-01
4813 C14orf126 1553801 a at 4.4061 E-02 3.88E-03 2.95 -2.09 1.83E-01
4814 SYNGR2 201079 at 4.4061 E-02 3.88E-03 -2.95 -2.09 -3.07E-01
4815 213710 s at 4.4061 E-02 3.88E-03 -2.95 -2.09 -2.74E-01
4816 MFSD7 205144 at 4.4061 E-02 3.88E-03 2.95 -2.09 2.05E-01
4817 NOSIP 217950 at 4.4061 E-02 3.88E-03 2.95 -2.09 3.35E-01
4818 LZTS1 221721 s at 4.4068E-02 3.88E-03 2.95 -2.09 1.44E-01
4819 MMP14 202828 s at 4.4068E-02 3.88E-03 -2.95 -2.09 -3.51 E-01
4820 241351 at 4.4076E-02 3.89E-03 2.95 -2.09 1.77E-01
4821 SLC25A1 210010 s at 4.4076E-02 3.89E-03 -2.95 -2.09 -4.42E-01
4822 DMRTC1B/// 1553998_at 4.4076E-02 3.89E-03 2.95 -2.09 1.74E-01 DMRTC1
4823 CNOT7 218250 s at 4.4090E-02 3.89E-03 2.95 -2.09 2.29E-01
4824 RD3 236563 at 4.4090E-02 3.89E-03 2.95 -2.09 1 45E-01
4825 FLJ77644/// 1552303_a_at 4.4092E-02 3.89E-03 -2.95 -2.09 -2.67E-01 TMEM106A
No. Gene* Probe ID" Adj. p value P value ί B Log FC
4826 SIGLEC1 219519 s at 4.4095E-02 3.89E-03 -2.95 -2.09 -7.06E-01
4827 NACAP1 211445 x at 4.4095E-02 3.89E-03 2.95 -2.09 1.16E-01
4828 SMARCA5 202303 x at 4.4095E-02 3.89E-03 -2.95 -2.09 -3.16E-01
4829 PLCL2 216218 s at 4.4095E-02 3.89E-03 -2.95 -2.09 -4.42E-01
4830 C1orf50 219406 at 4.4107E-02 3.90E-03 2.95 -2.09 3.86E-01
4831 FA 98A 241832 at 4.4140E-02 3.90E-03 2.95 -2.09 1.26E-01
4832 VPS37A 225378 at 4.4140E-02 3.90E-03 -2.95 -2.09 -2.77E-01
4833 AGR3 228241 at 4.4145E-02 3.90E-03 2.95 -2.09 1.04E-01
4834 C14orf64 1559097 at 4.4147E-02 3.90E-03 2.95 -2.09 3.80E-01
4835 SNRPA1 242146 at 4.4167E-02 3.91 E-03 2.95 -2.09 3.90E-01
4836 SLC25A11 209003 at 4.4176E-02 3.91 E-03 -2.95 -2.09 -4.50E-01
4837 GABRB3 1569689 s at 4.4185E-02 3.91 E-03 2.95 -2.10 1.19E-01
4838 P2 201069 at 4.4224E-02 3.91 E-03 -2.94 -2.10 -1.05E+00
4839 FOXP2 1564876 s at 4.4229E-02 3.91 E-03 2.94 -2.10 1.55E-01
4840 C14orf91 1570162 at 4.4264E-02 3.92E-03 2.94 -2.10 1.01 E-01
4841 HLA-E 217456_x_at 4.4312E-02 3.92E-03 -2.94 -2.10 -2.65E-01
4842 240693 at 4.4312E-02 3.92E-03 2.94 -2.10 9.25E-02
4843 DERL3 229721 x at 4.4384E-02 3.93E-03 -2.94 -2.10 -5.43E-01
4844 ACRV1 207973 x at 4.4451 E-02 3.94E-03 2.94 -2.10 1.23E-01
4845 ZNF169 1560922 s at 4.4460E-02 3.94E-03 2.94 -2.10 1.53E-01
4846 COA4 210774 s at 4.4473E-02 3.94E-03 -2.94 -2.10 -2.88E-01
4847 ARL17A 243899 at 4.4490E-02 3.94E-03 2.94 -2.10 2.99E-01
4848 GPD2 225447 at 4.4490E-02 3.94E-03 -2.94 -2.10 -4.12E-01
4849 GNAS 200780 x at 4.4593E-02 3.96E-03 -2.94 -2.11 -4.29E-01
4850 EL 03 219411 at 4.4593E-02 3.96E-03 2.94 -2.11 1.74E-01
4851 240695 at 4.4593 E-02 3.96E-03 2.94 -2.11 1.41E-01
4852 RELL2 1564031 a at 4.4623E-02 3.96E-03 2.94 -2.11 1.79E-01
4853 PECA 1 208981_at 4.4623E-02 3.96E-03 -2.94 -2.11 -4.70E-01
4854 KLF3 225140 at 4.4623E-02 3.96E-03 -2.94 -2.11 -3.18E-01
4855 LRRFIP1 238840 at 4.4623E-02 3.96E-03 2.94 -2.11 1.92E-01
4856 PARVB 37965 at 4.4623E-02 3.97E-03 -2.94 -2.11 -4.43E-01
4857 SYN1 1553264 a at 4.4623E-02 3.97E-03 2.94 -2.11 1.84E-01
4858 228826 at 4.4623E-02 3.97E-03 2.94 -2.11 4.60E-01
4859 CLIC6 242913 at 4.4623E-02 3.97E-03 -2.94 -2.11 -1.70E-01
4860 NCRNA001 1552872_at 4.4623E-02 3.97E-03 2.94 -2.11 2.13E-01 05
4861 IFRD2 209100 at 4.4623E-02 3.97E-03 -2.94 -2.11 -1.86E-01
4862 PLIN2 209122 at 4.4623E-02 3.97E-03 -2.94 -2.11 -3.37E-01
4863 1558783 at 4.4623E-02 3.97E-03 2.94 -2.11 3.52E-01
4864 236897 at 4.4623E-02 3.97E-03 2.94 -2.11 1.77E-01
4865 GNA11 564 at 4.4623E-02 3.97E-03 -2.94 -2.11 -3.86E-01
4866 NGRN 217722 s at 4.4623E-02 3.97E-03 -2.94 -2.11 -3.03E-01
4867 BCLAF1 229454 at 4.4623E-02 3.97E-03 2.94 -2.11 3.20E-01
4868 ATG7 222709 at 4.4627E-02 3.97E-03 -2.94 -2.11 -2.53E-01
4869 215484 at 4.4627E-02 3.97E-03 2.94 -2.11 1.43E-01
4870 1556393 at 4.4627E-02 3.98E-03 2.94 -2.11 1.31E-01
4871 SPIRE1 224995 at 4.4627E-02 3.98E-03 -2.94 -2.11 -3.16E-01
4872 L0C100287 1569615_at 4.4652E-02 3.98E-03 2.94 -2.11 1.81E-01 249
4873 PRKAR2B 203680 at 4.4660E-02 3.98E-03 -2.94 -2.11 -4.18E-01
4874 NT5DC2 218051 s at 4.4660E-02 3.98E-03 -2.94 -2.11 -4.30E-01
4875 FYTTD1 224642 at 4.4660E-02 3.98E-03 -2.94 -2.11 -3.70E-01
4876 GNG2 1555766 a at 4.4668E-02 3.98E-03 -2.94 -2.11 -2.80E-01
4877 TTLL3///AR 217818_s_at 4.4681 E-02 3.99E-03 2.94 -2.11 2.70E-01 PC4
4878 C0X11 203551 s at 4.4681 E-02 3.99E-03 2.94 -2.11 2.47E-01
4879 ADRA2A 209869 at 4.4685E-02 3.99E-03 -2.94 -2.11 -6.38E-01
4880 SERBP1 210076 x at 4.4686E-02 3.99E-03 -2.94 -2.11 -2.14E-01
4881 IFNA14 208182 x at 4.4691 E-02 3.99E-03 2.94 -2.11 1.21E-01
4882 PLEKHB2 201411 s at 4.4696E-02 3.99E-03 -2.94 -2.11 -5.08E-01
4883 WIPI2 204710 s at 4.4704E-02 3.99E-03 -2.94 -2.11 -3.06E-01
4884 KPNA4 209653 at 4.4726E-02 4.00E-03 -2.94 -2.11 -3.56E-01
4885 ANEA 1555227 a at 4.4726E-02 4.00E-03 -2.94 -2.11 -1.28E-01
4886 TI 8A 205217 at 4.4726E-02 4.00E-03 2.94 -2.11 3.81 E-01
4887 MYLK 202555 s at 4.4726E-02 4.00E-03 -2.94 -2.11 -5.35E-01
4888 CDIPT 201253 s at 4.4734E-02 4.00E-03 -2.94 -2.12 -3.86E-01
4889 PGRMC1 201120 s at 4.4744E-02 4.00E-03 -2.94 -2.12 -3.41 E-01
4890 HAS 3 1552980 at 4.4744E-02 4.00E-03 -2.94 -2.12 -1.30E-01
4891 PI15 229947 at 4.4744E-02 4.00E-03 -2.94 -2.12 -1.17E+00
No. Gene* Probe ID" Adj. p value P value f B Log FC
4892 ARID2 225486 at 4.4762E-02 4.01 E-03 2.94 -2.12 2.09E-01
4893 ANGPT2 205572 at 4.4762E-02 4.01 E-03 -2.94 -2.12 -3.20E-01
4894 NXNL1 1553755 at 4.4765E-02 4.01 E-03 2.94 -2.12 1.96E-01
4895 K1AA1659 215674 at 4.4765E-02 4.01 E-03 2.94 -2.12 9.42E-02
4896 TP53INP2 224836 at 4.4765E-02 4.01 E-03 -2.94 -2.12 -2.82E-01
4897 HELQ 228736 at 4.4765E-02 4.01 E-03 2.94 -2.12 4.61 E-01
4898 TIFA 238858 at 4.4765E-02 4.01 E-03 -2.94 -2.12 -1.72E-01
4899 NCOA2 215605 at 4.4774E-02 4.01 E-03 2.94 -2.12 2.64E-01
4900 NBPF8 237917 at 4.4907E-02 4.02E-03 2.94 -2.12 1.04E-01
4901 NFAM1 243099 at 4.4921 E-02 4.03E-03 -2.94 -2.12 -3.93E-01
4902 ZNF883 230876 at 4.4921 E-02 4.03E-03 2.94 -2.12 1.66E-01
4903 210748_at 4.4936E-02 4.03E-03 2.94 -2.12 1.19E-01
4904 1570044_at 4.4971 E-02 4.03E-03 2.93 -2.12 1.42E-01
4905 216297 at 4.4971 E-02 4.04E-03 2.93 -2.12 1.04E-01
4906 ABCF2 207623 at 4.4971 E-02 4.04E-03 2.93 -2.12 2.01 E-01
4907 ARFGAP3 202211 at 4.4971 E-02 4.04E-03 -2.93 -2.12 -2.48E-01
4908 SLC25A41 1555509 a at 4.4971 E-02 4.04E-03 2.93 -2.12 1.40E-01
4909 DCTD 210137 s at 4.4971 E-02 4.04E-03 -2.93 -2.12 -3.03E-01
4910 E2F1 2028 s at 4.4971 E-02 4.04E-03 2.93 -2.12 1.17E-01
4911 GALNT6 219956 at 4.4971 E-02 4.04E-03 -2.93 -2.12 -2.50E-01
4912 FCF1 215567 at 4.5015E-02 4.04E-03 2.93 -2.12 2.02E-01
4913 CPA5 240744 at 4.5099E-02 4.05E-03 2.93 -2.13 3.15E-01
4914 241542 at 4.5099E-02 4.05E-03 2.93 -2.13 1.22E-01
4915 T1MD4 1552280 at 4.5110E-02 4.06E-03 -2.93 -2.13 -6.18E-01
4916 VPS35 222387 s at 4.5120E-02 4.06E-03 -2.93 -2.13 -4.13E-01
4917 241514 at 4.5120E-02 4.06E-03 2.93 -2.13 1.31 E-01
4918 PHTF2 1554822 at 4.5183E-02 4.06E-03 2.93 -2.13 1.23E-01
4919 NSUN3 219458 s at 4.5193E-02 4.07E-03 2.93 -2.13 2.87E-01
4920 SLC4A10 206830 at 4.5230E-02 4.07E-03 2.93 -2.13 7.64E-02
4921 239017 at 4.5285E-02 4.08E-03 2.93 -2.13 3.12E-01
4922 DCTN1 201082_s_at 4.5314E-02 4.08E-03 -2.93 -2.13 -4.56E-01
4923 PPP3CC 207000_s_at 4.5317E-02 4.08E-03 2.93 -2.13 2.55E-01
4924 240909 at 4.5347E-02 4.08E-03 2.93 -2.13 1.38E-01
4925 APLNR 213592 at 4.5348E-02 4.09E-03 -2.93 -2.13 -3.97E-01
4926 238174 at 4.5348E-02 4.09E-03 2.93 -2.13 2.78E-01
4927 238278 at 4.5395E-02 4.09E-03 2.93 -2.13 1.14E-01
4928 MED7 204349 at 4.5400E-02 4.09E-03 2.93 -2.14 4.01 E-01
4929 LOC643733 240890 at 4.5413E-02 4.09E-03 2.93 -2.14 7.84E-01
4930 I SLR 207191 s at 4.5413E-02 4.09E-03 -2.93 -2.14 -4.51 E-01
4931 EL0VL1 57163 at 4.5416E-02 4.10E-03 -2.93 -2.14 -2.19E-01
4932 L.MAN2 200805 at 4.5430E-02 4.10E-03 -2.93 -2.14 -2.93E-01
4933 UBE2H 221962 s at 4.5435E-02 4.10E-03 -2.93 -2.14 -3.33E-01
4934 WFDC12 1553081 at 4.5435E-02 4.10E-03 -2.93 -2.14 -1.43E-01
4935 226231 at 4.5435E-02 4.10E-03 2.93 -2.14 1.17E-01
4936 DNAJC1 218409 s at 4.5435E-02 4.10E-03 -2.93 -2.14 -2.39E-01
4937 ZNF407 220836 at 4.5438E-02 4.10E-03 2.93 -2.14 8.95E-02
4938 242448 at 4.5446E-02 4.10E-03 2.93 -2.14 2.40E-01
4939 METTL3 2421 11 at 4.5474E-02 4.11 E-03 2.93 -2.14 2.74E-01
4940 LOC284749 236854 at 4.5505E-02 4.11 E-03 2.93 -2.14 2.20E-01
4941 TBCK 226126 at 4.5522E-02 4.11 E-03 -2.93 -2.14 -3.19E-01
4942 ANKRD17 225852 at 4.5567E-02 4.12E-03 -2.93 -2.14 -4.19E-01
4943 SP3 232529 at 4.5567E-02 4.12E-03 2.93 -2.14 3.48E-01
4944 TUBGCP2 202477 s at 4.5567E-02 4.12E-03 -2.93 -2.14 -3.54E-01
4945 FLJ37307 1557465 at 4.5594E-02 4.12E-03 2.93 -2.14 1.44E-01
4946 DDAH1 209094 at 4.5601 E-02 4.13E-03 -2.93 -2.14 -5.53E-01
4947 EPHA1 205977 s at 4.5612E-02 4.13E-03 2.93 -2.14 1.78E-01
4948 233137 at 4.5612E-02 4.13E-03 2.93 -2.14 3.22E-01
4949 AP2S1 202120 x at 4.5671 E-02 4.13E-03 -2.93 -2.14 -2.78E-01
4950 PARVA 217890 s at 4.5759E-02 4.14E-03 -2.93 -2.15 -5.16E-01
4951 240662 at 4.5759E-02 4.14E-03 2.93 -2.15 1.1 1 E-01
4952 AIF1 213095 x at 4.5763E-02 4.14E-03 -2.93 -2.15 -3.35E-01
4953 N0L.7 210097 s at 4.5768E-02 4.15E-03 -2.93 -2.15 -2.56E-01
4954 ARSB 206129 s at 4.5768E-02 4.15E-03 -2.93 -2.15 -2.46E-01
4955 HIP1 R 209559 at 4.5768E-02 4.15E-03 2.93 -2.15 1.54E-01
4956 C18orf21 223526 at 4.5768E-02 4.15E-03 2.93 -2.15 3.16E-01
4957 YPEL5 222408 s at 4.5768E-02 4.15E-03 2.93 -2.15 3.39E-01
4958 1558080 s at 4.5768E-02 4.15E-03 -2.93 -2.15 -4.70E-01
4959 MY09B 217297 s at 4.5768E-02 4.15E-03 -2.93 -2.15 -3.26E-01
4960 TRPM1 214410 at 4.5768E-02 4.15E-03 2.93 -2.15 1.00E-01
No. Gene* Probe ID** Adj. p value P value t e Log FC
4961 NUP62 202153 s at 4.5780E-02 4.15E-03 -2.92 -2.15 -3.45E-01
4962 SARNP 229069 at 4.5811E-02 4.16E-03 2.92 -2.15 3.57E-01
4963 DEFA5 207529 at 4.5819E-02 4.16E-03 2.92 -2.15 1.18E-01
4964 LRRC37B2 216149 at 4.5822E-02 4.16E-03 2.92 -2.15 1.03E-01
4965 HDDC2 203260 at 4.5826E-02 4.16E-03 2.92 -2.15 2.86E-01
4966 DHRS11 218756 s at 4.5826E-02 4.16E-03 -2.92 -2.15 -1.20E-01
4967 ZNF235 210595 at 4.5835E-02 4.16E-03 2.92 -2.15 1.20E-01
4968 1564851 at 4.5837E-02 4.16E-03 2.92 -2.15 1.27E-01
4969 RBM26 229433 at 4.5845E-02 4.17E-03 2.92 -2.15 2.54E-01
4970 ATP8B1 238055 at 4.5899E-02 4.17E-03 2.92 -2.15 3.38E-01
4971 ZNF81 242083 at 4.5912E-02 4.17E-03 2.92 -2.15 1.57E-01
4972 PNRC2 217779 s at 4.5918E-02 4.18E-03 2.92 -2.15 2.21 E-01
4973 DHRSX 225503 at 4.5918E-02 4.18E-03 -2.92 -2.15 -3.25E-01
4974 ZNF567 242429 at 4.5921 E-02 4.18E-03 2.92 -2.15 3.32E-01
4975 SMG5 34868 at 4.5943E-02 4.18E-03 -2.92 -2.15 -1.64E-01
4976 BPF10///N 201104_x_at 4.5944E-02 4.18E-03 -2.92 -2.15 -5.14E-01
BPF16///NB
PF24///NBP
F8///NBPF1
2///AE01///N
BPF9///NBP
F15///NBPF
1 1///KIAA12
45///NBPF1//
/NBPF14
4977 WDR66 1555007 s at 4.5948E-02 4.18E-03 2.92 -2.15 1.36E-01
4978 DERL1 225488 at 4.5948E-02 4.18E-03 2.92 -2.15 2.32E-01
4979 WDR45 209217 s at 4.5948E-02 4.18E-03 -2.92 -2.15 -3.25E-01
4980 SETD3 212465 at 4.6025E-02 4.19E-03 -2.92 -2.16 -1.58E-01
4981 ETNK1 224454 at 4.6025E-02 4.19E-03 2.92 -2.16 1.38E-01
4982 SYNPO 202796 at 4.6028E-02 4.19E-03 -2.92 -2.16 -3.90E-01
4983 NMUR1 221383 at 4.6065E-02 4.20E-03 2.92 -2.16 1.56E-01
4984 PAWR 214237 x at 4.6070E-02 4.20E-03 2.92 -2.16 2.07E-01
4985 ELAVL2 228260 at 4.6070E-02 4.20E-03 2.92 -2.16 1.08E-01
4986 LOC641518 243362 s at 4.61 10E-02 4.20E-03 2.92 -2.16 5.01 E-01
4987 SLC38A6 214830 at 4.6126E-02 4.21 E-03 -2.92 -2.16 -6.39E-01
4988 EXOC5 228418 at 4.6126E-02 4.21 E-03 -2.92 -2.16 -4.36E-01
4989 UBE2L3 200684 s at 4.6126E-02 4.21 E-03 -2.92 -2.16 -3.48E-01
4990 RHOQ 212117 at 4.6126E-02 4.21 E-03 -2.92 -2.16 -3.08E-01
4991 236558 at 4.6145E-02 4.21 E-03 2.92 -2.16 4.62E-01
4992 SNAPC4 215926 x at 4.6146E-02 4.21 E-03 2.92 -2.16 1.93E-01
4993 ANKHD1 229457 at 4.6146E-02 4.21 E-03 2.92 -2.16 2.25E-01
4994 SLC27A5 219733 s at 4.6156E-02 4.22E-03 2.92 -2.16 3.43E-01
4995 COBRA1 202757 at 4.6156E-02 4.22E-03 -2.92 -2.16 -3.54E-01
4996 C14orf28 235369 at 4.6168E-02 4.22E-03 2.92 -2.16 2.55E-01
4997 DARC 208335 s at 4.6168E-02 4.22E-03 -2.92 -2.16 -5.32E-01
4998 UBX 6 223012 at 4.6168E-02 4.22E-03 -2.92 -2.16 -3.09E-01
4999 TRIM73 1554250 s at 4.6168E-02 4.22E-03 2.92 -2.16 3.02E-01
5000 239387 at 4.6187E-02 4.22E-03 2.92 -2.16 2.74E-01
5001 244061 at 4.6250E-02 4.23E-03 2.92 -2.16 5.60E-01
5002 SRBD1 219055 at 4.6265E-02 4.23E-03 2.92 -2.16 2.75E-01
5003 TBL2 212679 at 4.6265E-02 4.23E-03 2.92 -2.16 1.18E-01
5004 244002 at 4.6265E-02 4.23E-03 2.92 -2.16 1.57E-01
5005 BUB3 201456 s at 4.6279E-02 4.24E-03 2.92 -2.17 2.56E-01
5006 225269 s at 4.6286E-02 4.24E-03 -2.92 -2.17 -2.82E-01
5007 LDLR 202067 s at 4.6286E-02 4.24E-03 -2.92 -2.17 -2.32E-01
5008 SLC5A3 212944 at 4.6295E-02 4.24E-03 -2.92 -2.17 -4.20E-01
5009 UBE3A 234163 at 4.6295E-02 4.24E-03 2.92 -2.17 1.29E-01
5010 TMEM8B 207839 s at 4.6306E-02 4.24E-03 2.92 -2.17 1.59E-01
5011 PAT 209798 at 4.6323E-02 4.25E-03 2.92 -2.17 2.62E-01
5012 NEK2 204641 at 4.6343E-02 4.25E-03 2.92 -2.17 3.87E-01
5013 MSRB2 218773 s at 4.6354E-02 4.25E-03 -2.92 -2.17 -3.95E-01
5014 STYXL1 222591 at 4.6363E-02 4.25E-03 2.92 -2.17 1.59E-01
5015 C17orf104 1566478 at 4.6363E-02 4.25E-03 2.92 -2.17 8.60E-02
5016 239266 at 4.6363E-02 4.25E-03 2.92 -2.17 1.92E-01
5017 ME1 204058 at 4.6363E-02 4.25E-03 -2.92 -2.17 -6.78E-01
5018 COG6 232786 at 4.6388E-02 4.26E-03 2.92 -2.17 9.39E-02
5019 LOC441666 1559503 a at 4.6424E-02 4.26E-03 2.92 -2.17 9.50E-02
5020 LOC401320 233732 at 4.6436E-02 4.26E-03 2.92 -2.17 1.93E-01
5021 241656 at 4.6481 E-02 4.27E-03 2.92 -2.17 1.15E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
5022 PROSC 214545 s at 4.6487E-02 4.27E-03 -2.92 -2.17 -4.58E-01
5023 234564 at 4.6490E-02 4.27E-03 2.92 -2.17 1.32E-01
5024 TAF1 216711 s at 4.6490E-02 4.27E-03 -2.92 -2.17 -1.63E-01
5025 BBX 223135 s at 4.6490E-02 4.27E-03 -2.92 -2.17 -4.63E-01
5026 TBXAS1 236345 at 4.6490E-02 4.27E-03 -2.92 -2.17 -2.41 E-01
5027 CDV3 212010 s at 4.6490E-02 4.27E-03 -2.92 -2.17 -3.28E-01
5028 NID2 204114 at 4.6530E-02 4.28E-03 -2.91 -2.17 -7.65E-01
5029 RPS13 200018 at 4.6547E-02 4.28E-03 2.91 -2.17 1.41 E-01
5030 RBBP4 239071 at 4.6547E-02 4.28E-03 2.91 -2.17 3.44E-01
5031 ADAP1 219150 s at 4.6568E-02 4.29E-03 -2.91 -2.18 -2.21 E-01
5032 RBM39 238355 at 4.6568E-02 4.29E-03 2.91 -2.18 1.21 E-01
5033 ACAN 205679 x at 4.6568E-02 4.29E-03 -2.91 -2.18 -1.69E-01
5034 UPF3B 240993 at 4.6568E-02 4.29E-03 2.91 -2.18 1.27E-01
5035 PCP2 244751 at 4.6568E-02 4.29E-03 2.91 -2.18 1.52E-01
5036 LTBP3 237144 at 4.6568E-02 4.29E-03 2.91 -2.18 1.86E-01
5037 243078 at 4.6586E-02 4.29E-03 2.91 -2.18 1.40E-01
5038 220969 s at 4.6589E-02 4.29E-03 2.91 -2.18 1.96E-01
5039 SRSF4 241245 at 4.6593E-02 4.29E-03 2.91 -2.18 9.26E-02
5040 228661_s_at 4.6628E-02 4.30E-03 2.91 -2.18 5.34E-01
5041 E 203435 s at 4.6628E-02 4.30E-03 -2.91 -2.18 -5.76E-01
5042 1562984 at 4.6642E-02 4.30E-03 2.91 -2.18 1.41 E-01
5043 SE A3A 244163 at 4.6666E-02 4.30E-03 -2.91 -2.18 -9.64E-02
5044 PTPRE 221840 at 4.6676E-02 4.31 E-03 -2.91 -2.18 -4.12E-01
5045 BAP1 201419 at 4.6693E-02 4.31 E-03 -2.91 -2.18 -2.86E-01
5046 SLC24A2 220867 s at 4.6738E-02 4.31 E-03 2.91 -2.18 1.42E-01
5047 PARVB 216254_at 4.6763E-02 4.32E-03 -2.91 -2.18 -1.01 E-01
5048 GOLGA8A 208797 s at 4.6773E-02 4.32 E-03 2.91 -2.18 4.29E-01
5049 PRKCZ 202178 at 4.6773E-02 4.32E-03 2.91 -2.18 4.10E-01
5050 DUSP28 229211 at 4.6829E-02 4.33E-03 2.91 -2.18 3.34E-01
5051 ID1 IP1 218251 at 4.6840E-02 4.33E-03 -2.91 -2.18 -3.38E-01
5052 RC3H2 225813 at 4.6840E-02 4.33E-03 -2.91 -2.18 -1.59E-01
5053 PHF21 B 1560091 a at 4.6840E-02 4.33E-03 2.91 -2.18 1.29E-01
5054 KIAA1755 1561393 at 4.6840E-02 4.33E-03 2.91 -2.18 2.03E-01
5055 244539 at 4.6840E-02 4.33E-03 2.91 -2.18 1.21 E-01
5056 FGD6 1555137 a at 4.6840E-02 4.33E-03 -2.91 -2.18 -2.03E-01
5057 240850 at 4.6840E-02 4.33E-03 2.91 -2.18 9.32E-02
5058 SLC8A1 1556583 a at 4.6870E-02 4.34E-03 -2.91 -2.19 -1.64E-01
5059 235133 at 4.6895E-02 4.34E-03 2.91 -2.19 1.53E-01
5060 GABRA2 1554308 s at 4.6909E-02 4.34E-03 2.91 -2.19 9.07E-02
5061 ATP6V1 D 208899 x at 4.6951 E-02 4.35E-03 -2.91 -2.19 -3.08E-01
5062 NDUFS2 201966 at 4.6951 E-02 4.35E-03 -2.91 -2.19 -2.62E-01
5063 ANGPT2 211148 s at 4.6951 E-02 4.35E-03 -2.91 -2.19 -2.35E-01
5064 237773 at 4.6951 E-02 4.35 E-03 2.91 -2.19 1.54E-01
5065 SPZ1 224167 at 4.6955E-02 4.35E-03 2.91 -2.19 9.71 E-02
5066 CA12 210735 s at 4.6977E-02 4.35E-03 -2.91 -2.19 -4.61 E-01
5067 211435 at 4.6977E-02 4.35E-03 2.91 -2.19 1.59E-01
5068 EIF5A2 235289 at 4.6997E-02 4.36E-03 2.91 -2.19 2.21 E-01
5069 HNRNPH3 210110 x at 4.6997E-02 4.36E-03 -2.91 -2.19 -3.51 E-01
5070 PABPN1 201545 s at 4.7000E-02 4.36E-03 -2.91 -2.19 -2.38E-01
5071 DIP2B 242970 at 4.7035E-02 4.36E-03 2.91 -2.19 1.35E-01
5072 TBC1 D8 221592 at 4.7035E-02 4.36E-03 2.91 -2.19 1.43E-01
5073 HPYR1 1566916 at 4.7035E-02 4.36E-03 2.91 -2.19 1.37E-01
5074 TCERG1 229706 at 4.7035E-02 4.36E-03 2.91 -2.19 2.56E-01
5075 1560596 at 4.7039E-02 4.37E-03 2.91 -2.19 1.19E-01
5076 CCDC126 228087 at 4.7041 E-02 4.37E-03 2.91 -2.19 4.61 E-01
5077 T E 185A 227880 s at 4.7041 E-02 4.37E-03 -2.91 -2.19 -4.42E-01
5078 GOLGA1 203384 s at 4.7058E-02 4.37E-03 -2.91 -2.19 -3.02E-01
5079 1TGB2 202803 s at 4.7079E-02 4.37E-03 -2.91 -2.19 -5.66E-01
5080 EGR3 206115 at 4.7079E-02 4.37E-03 2.91 -2.19 3.70E-01
5081 SPINK1 206239 s at 4.7096E-02 4.38E-03 -2.91 -2.19 -2.61 E-01
5082 IMPDH1 204169 at 4.7102E-02 4.38E-03 -2.91 -2.19 -3.03E-01
5083 BYSL 203612 at 4.7124E-02 4.38E-03 -2.91 -2.19 -2.38E-01
5084 KIAA1683 223600 s at 4.7124E-02 4.38E-03 2.91 -2.19 1.51 E-01
5085 NCRNA000 238697_at 4.7124E-02 4.38E-03 2.91 -2.19 1.26E-01 86
5086 ATP1A2 203295 s at 4.7124E-02 4.38E-03 2.91 -2.20 1.10E-01
5087 C5orf44 1559369 at 4.7150E-02 4.39E-03 2.91 -2.20 1.22E-01
5088 SIX5 217661 x at 4.7150E-02 4.39E-03 2.91 -2.20 1.65E-01
5089 S4A1 210356 x at 4.7150E-02 4.39E-03 2.91 -2.20 8.26E-01
1 G5
No. Gene* Probe ID** Adj. p value P value ί B Log FC
5090 QSOX1 201482 at 4.7166E-02 4.39E-03 -2.91 -2.20 -2.53E-01
5091 DPP7 238012 at 4.7166E-02 4.39E-03 2.91 -2.20 3.38E-01
5092 MPZL1 210594 x at 4.7166E-02 4.39E-03 -2.91 -2.20 -2.16E-01
5093 E CN 219436 s at 4.7166E-02 4.39E-03 -2.91 -2.20 -4.06E-01
5094 241067 at 4.7166E-02 4.39E-03 2.91 -2.20 1.05E-01
5095 PIK3CA 235980 at 4.7183E-02 4.40E-03 2.91 -2.20 1.60E-01
5096 DOC 1 203187 at 4.7205E-02 4.40E-03 -2.91 -2.20 -2.14E-01
5097 PAIP1 208051 s at 4.721 OE-02 4.40E-03 2.91 -2.20 2.99E-01
5098 TAP2 204770 at 4.721 OE-02 4.40E-03 -2.91 -2.20 -3.00E-01
5099 ZNF143 221873 at 4.7229E-02 4.40E-03 2.91 -2.20 3.03E-01
5100 ZNF638 1554248_at 4.7229E-02 4.41 E-03 2.91 -2.20 1.98E-01
5101 RBCK1 221827_at 4.7229E-02 4.41 E-03 2.91 -2.20 2.09E-01
5102 ALG3 207396_s_at 4.7261 E-02 4.41 E-03 -2.90 -2.20 -2.96E-01
5103 241454_at 4.7261 E-02 4.41 E-03 2.90 -2.20 1.34E-01
5104 ANGPTL2 213004 at 4.7277E-02 4.41 E-03 -2.90 -2.20 -5.14E-01
5105 C9orf5 227831 at 4.7329E-02 4.42E-03 2.90 -2.20 1.18E-01
5106 TRPC4AP 212059 s at 4.7329E-02 4.42E-03 -2.90 -2.20 -2.56E-01
5107 TMEM185A 1554105 at 4.7329E-02 4.42E-03 -2.90 -2.20 -2.08E-01
5108 FBN3 240117 at 4.7329E-02 4.42E-03 2.90 -2.20 1.46E-01
5109 SEC14L1 202084 s at 4.7391 E-02 4.43E-03 -2.90 -2.20 -4.72E-01
5110 SLC25A12 203339 at 4.7391 E-02 4.43E-03 2.90 -2.20 2.72E-01
5111 ZDHHC5 224858 at 4.7391 E-02 4.43E-03 -2.90 -2.20 -1.94E-01
5112 FAM46A 221766 s at 4.7429E-02 4.43E-03 -2.90 -2.21 -4.45E-01
5113 RNPC3 229903 x at 4.7429E-02 4.44 E-03 2.90 -2.21 2.84E-01
5114 ACYP2 206833 s at 4.7452E-02 4.44E-03 2.90 -2.21 5.82E-01
5115 PDZK1P1 240634 x at 4.7469E-02 4.44E-03 2.90 -2.21 1.37E-01
5116 242225 at 4.7469E-02 4.44E-03 2.90 -2.21 3.39E-01
5117 231827 at 4.7469E-02 4.44E-03 2.90 -2.21 2.11E-01
5118 LOC338799 1556042 s at 4.7488E-02 4.45E-03 2.90 -2.21 1.96E-01
5119 BRI3 223376 s at 4.7492E-02 4.45E-03 -2.90 -2.21 -3.73E-01
5120 ATP5S 238799 at 4.7516E-02 4.45E-03 2.90 -2.21 1.27E-01
5121 PIK3R2 207105 s at 4.7529E-02 4.45 E-03 -2.90 -2.21 -1.30E-01
5122 CSF1 209716_at 4.7553E-02 4.45E-03 -2.90 -2.21 -2.53E-01
5123 PCTP 218676 s at 4.7574E-02 4.46E-03 -2.90 -2.21 -3.09E-01
5124 ERCC2 213468_at 4.7617E-02 4.46E-03 -2.90 -2.21 -1.68E-01
5125 IQCH 220361_at 4.7631 E-02 4.46E-03 2.90 -2.21 8.73E-02
5126 C17orf90 50374 at 4.7661 E-02 4.47E-03 2.90 -2.21 1.60E-01
5127 LOC100128 1556724_at 4.7670E-02 4.47E-03 2.90 -2.21 1.25E-01 398
5128 ZNF143 206428 s at 4.7670E-02 4.47E-03 2.90 -2.21 1.29E-01
5129 ATF7IP 216197 at 4.7681 E-02 4.47E-03 2.90 -2.21 2.48E-01
5130 NEURL2 230283 at 4.7706E-02 4.48E-03 -2.90 -2.21 -3.16E-01
5131 CAPN2 208683 at 4.7734E-02 4.48E-03 -2.90 -2.21 -3.30E-01
5132 PTPLAD1 217777 s at 4.7734E-02 4.48E-03 -2.90 -2.21 -2.83E-01
5133 1554957 at 4.7734E-02 4.48E-03 2.90 -2.21 1.27E-01
5134 TADA2B 236248 x at 4.7738E-02 4.48E-03 2.90 -2.21 3.09E-01
5135 METTL8 220007 at 4.7753E-02 4.48E-03 2.90 -2.21 4.61E-01
5136 DNAJC7 202416 at 4.7772E-02 4.49E-03 -2.90 -2.22 -3.67E-01
5137 KIAA0427 204303 s at 4.7772E-02 4.49E-03 -2.90 -2.22 -1.77E-01
5138 LAPTM4B 208029 s at 4.7839E-02 4.50E-03 -2.90 -2.22 -4.73E-01
5139 C10orf84 218390 s at 4.7839E-02 4.50E-03 2.90 -2.22 2.10E-01
5140 ME2 210154 at 4.7840E-02 4.50E-03 -2.90 -2.22 -5.43E-01
5141 RPS6KC1 218909 at 4.7879E-02 4.50E-03 -2.90 -2.22 -3.15E-01
5142 TRIM61 240342 at 4.7915E-02 4.51 E-03 2.90 -2.22 3.30E-01
5143 CNP 208912 s at 4.7915E-02 4.51 E-03 -2.90 -2.22 -3.15E-01
5144 CD52 204661 at 4.7925E-02 4.51 E-03 2.90 -2.22 4.75E-01
5145 FAM162A 220942 x at 4.7978E-02 4.51 E-03 2.90 -2.22 3.13E-01
5146 LOC285778 1563662 at 4.7987E-02 4.52E-03 2.90 -2.22 1.33E-01
5147 TCP11L2 1569206 at 4.7987E-02 4.52E-03 2.90 -2.22 2.18E-01
5148 HIP 2 225116 at 4.8012E-02 4.52E-03 -2.90 -2.22 -4.02E-01
5149 LRP11 225060 at 4.8012E-02 4.52E-03 -2.90 -2.22 -4.59E-01
5150 C9orf5 223005 s at 4.8012E-02 4.52E-03 -2.90 -2.22 -3.86E-01
5151 LIMA1 222456 s at 4.8012E-02 4.52E-03 -2.90 -2.22 -1.47E-01
5152 ACADVL 200710 at 4.8012E-02 4.52 E-03 -2.90 -2.22 -3.64E-01
5153 243646 at 4.8039E-02 4.53E-03 2.90 -2.22 1.94E-01
5154 TYROBP 204122 at 4.8062E-02 4.53E-03 -2.90 -2.22 -5.19E-01
5155 ADRM1 201281 at 4.8062E-02 4.53E-03 -2.90 -2.22 -3.78E-01
5156 243501 at 4.8062E-02 4.53E-03 2.90 -2.22 2.37E-01
5157 N4BP1 204601 at 4.8066E-02 4.53E-03 -2.90 -2.22 -2.60E-01
No. Gene* Probe ID** Adj. p value P value f 8 Log FC
5158 TERT 1555271 a at 4.8150E-02 4.54E-03 2.89 -2.23 1.17E-01
5159 237854 at 4.8150E-02 4.54E-03 2.89 -2.23 1.69E-01
5160 CSNK1A1P 1559651 at 4.8150E-02 4.54E-03 2.89 -2.23 8.94E-02
5161 1558651 at 4.8150E-02 4.55E-03 2.89 -2.23 9.63E-02
5162 NSMCE2 226536 at 4.8156E-02 4.55E-03 2.89 -2.23 4.61 E-01
5163 DAAM1 244062 at 4.8167E-02 4.55E-03 2.89 -2.23 1.89E-01
5164 BOLA3 227291 s at 4.8207E-02 4.55E-03 2.89 -2.23 4.33E-01
5165 WDR4 226882 x at 4.8222E-02 4.56E-03 -2.89 -2.23 -1.99E-01
5166 LOC730091 230780 at 4.8222E-02 4.56E-03 2.89 -2.23 1.82E-01
5167 LOC100132 1558310_s_at 4.8251 E-02 4.56E-03 2.89 -2.23 1.92E-01 356
5168 240749 at 4.8251 E-02 4.56E-03 2.89 -2.23 8.23E-02
5169 MEIG1 238158 at 4.8251 E-02 4.56E-03 2.89 -2.23 2.75E-01
5170 FNTA 200090 at 4.8251 E-02 4.56E-03 2.89 -2.23 2.06E-01
5171 PSIP1 209337 at 4.8269E-02 4.57E-03 2.89 -2.23 3.28E-01
5172 GOLGA4 215203 at 4.8270E-02 4.57E-03 2.89 -2.23 2.62E-01
5173 241315 at 4.8288E-02 4.57E-03 2.89 -2.23 1.61 E-01
5174 1569807_at 4.831 OE-02 4.57E-03 2.89 -2.23 1.63E-01
5175 235601 at 4.8319E-02 4.57E-03 2.89 -2.23 3.03E-01
5176 GALNT1 1568618 a at 4.8346E-02 4.58E-03 -2.89 -2.23 -3.43E-01
5177 MBOAT7 209179 s at 4.8408E-02 4.58E-03 -2.89 -2.23 -3.43E-01
5178 UBA1 200964 at 4.8408E-02 4.58E-03 -2.89 -2.23 -5.46E-01
5179 TNIP2 218335 x at 4.8429E-02 4.59E-03 -2.89 -2.23 -2.44E-01
5180 VOPP1 208091 s at 4.8444E-02 4.59E-03 -2.89 -2.23 -2.56E-01
5181 EFEMP1 201843 s at 4.8462E-02 4.59E-03 -2.89 -2.24 -7.79E-01
5182 RPL31 200963 x at 4.8465E-02 4.60E-03 2.89 -2.24 1.46E-01
5183 228533_at 4.8465E-02 4.60E-03 2.89 -2.24 1.33E-01
5184 ZNF589 210061_at 4.8465E-02 4.60E-03 -2.89 -2.24 -1.32E-01
5185 SPATA6 220298_s_at 4.8465E-02 4.60E-03 -2.89 -2.24 -1.08E-01
5186 243030 at 4.8465E-02 4.60E-03 2.89 -2.24 4.25E-01
5187 CABP5 221160 s at 4.8465E-02 4.60E-03 2.89 -2.24 1.05E-01
5188 GTSE1 204317 at 4.8465E-02 4.60E-03 -2.89 -2.24 -1.68E-01
5189 TBC1 D16 222116 s at 4.8465E-02 4.60E-03 -2.89 -2.24 -4.60E-01
5190 C6orf54 211351 at 4.8465E-02 4.60E-03 2.89 -2.24 1.00E-01
5191 FAM178A 203481 at 4.8465E-02 4.60E-03 -2.89 -2.24 -2.30E-01
5192 KIF1 B 209234 at 4.8465E-02 4.60E-03 -2.89 -2.24 -2.69E-01
5193 SNX17 200991 s at 4.8465E-02 4.60E-03 -2.89 -2.24 -3.88E-01
5194 230003 at 4.8465E-02 4.61 E-03 2.89 -2.24 2.48E-01
5195 241091 at 4.8465E-02 4.61 E-03 2.89 -2.24 1.80E-01
5196 IRGQ 1555833 a at 4.8465E-02 4.61 E-03 -2.89 -2.24 -2.48E-01
5197 RALGAPA1 235524 at 4.8465E-02 4.61 E-03 2.89 -2.24 1.45E-01
5198 TAP2 204769 s at 4.8465E-02 4.61 E-03 -2.89 -2.24 -3.76E-01
5199 ATPBD4 238662 at 4.8479E-02 4.61 E-03 2.89 -2.24 3.94E-01
5200 ETV4 1554576 a at 4.8514E-02 4.61 E-03 2.89 -2.24 1.46E-01
5201 231351 at 4.8524E-02 4.62E-03 2.89 -2.24 1.86E-01
5202 KPNA1 202058 s at 4.8524E-02 4.62E-03 -2.89 -2.24 -3.63E-01
5203 236303 at 4.8555E-02 4.62E-03 2.89 -2.24 1.31 E-01
5204 NCRNAODO 228993_s_at 4.8576E-02 4.62E-03 2.89 -2.24 2.47E-01 81
5205 AFG3L2 202486 at 4.8576E-02 4.62E-03 -2.89 -2.24 -3.02E-01
5206 PDGFA 205463 s at 4.8592E-02 4.63E-03 -2.89 -2.24 -4.15E-01
5207 240872 at 4.8602E-02 4.63E-03 2.89 -2.24 1.43E-01
5208 STAG3L4 222801 s at 4.8627E-02 4.63E-03 2.89 -2.24 4.05E-01
5209 GSS 211630 s at 4.8656E-02 4.64E-03 -2.89 -2.24 -2.25E-01
5210 241993 x at 4.8656E-02 4.64E-03 2.89 -2.24 3.16E-01
5211 MRPL1 223154 at 4.8656E-02 4.64E-03 2.89 -2.24 3.77E-01
5212 1570266 x at 4.8664E-02 4.64E-03 2.89 -2.24 1.90E-01
5213 ZDHHC13 232440 at 4.8667E-02 4.64E-03 2.89 -2.24 2.04E-01
5214 SET 40189 at 4.8677E-02 4.64E-03 -2.89 -2.24 -2.99E-01
5215 C20orf196 235064 s at 4.8699E-02 4.64E-03 2.89 -2.25 2.67E-01
5216 NAPA 208751 at 4.8715E-02 4.65E-03 -2.89 -2.25 -6.32E-01
5217 232261 at 4.8743E-02 4.65E-03 2.89 -2.25 1.23E-01
5218 ZNF317 225296 at 4.8743E-02 4.65E-03 -2.89 -2.25 -3.53E-01
5219 CCNT2 213743 at 4.8760E-02 4.65E-03 2.89 -2.25 3.08E-01
5220 LOC346887 235205 at 4.8763E-02 4.66E-03 2.89 -2.25 1.68E-01
5221 RPAIN 216962 at 4.8765E-02 4.66E-03 2.89 -2.25 1.81 E-01
5222 LOC388789 226236 at 4.8765E-02 4.66E-03 2.89 -2.25 4.55E-01
5223 GAB1 225998 at 4.8825E-02 4.66E-03 -2.89 -2.25 -2.46E-01
5224 SFRP1 228413 s at 4.8828E-02 4.67E-03 2.89 -2.25 1.55E-01
No. Gene* Probe ID** Adj. p value P value t B Log FC
5225 1566535 at 4.8828E-02 4.67E-03 2.89 -2.25 1.17E-01
5226 PHACTR2 204047 s at 4.8844E-02 4.67E-03 -2.89 -2.25 -3.99E-01
5227 C9orf86 225377 at 4.8844E-02 4.67E-03 -2.89 -2.25 -4.21 E-01
5228 TFE3 212457 at 4.8844E-02 4.67E-03 -2.89 -2.25 -3.11 E-01
5229 ZNF131 221842 s at 4.8844E-02 4.67E-03 2.89 -2.25 1.98E-01
5230 LI 9 235039 x at 4.8854E-02 4.67E-03 2.89 -2.25 1.28E-01
5231 JAM3 212813 at 4.8854E-02 4.67E-03 -2.89 -2.25 -3.99E-01
5232 RASSF1 240278 at 4.8857E-02 4.68E-03 2.89 -2.25 1.65E-01
5233 C18orf10 244233 at 4.8872E-02 4.68E-03 2.88 -2.25 1.04E-01
5234 EXOC7 212026 s at 4.8876E-02 4.68E-03 -2.88 -2.25 -2.50E-01
5235 BET1 L 223023 at 4.8886E-02 4.68E-03 -2.88 -2.25 -3.72E-01
5236 SLC30A5 220181 x at 4.8886E-02 4.68E-03 2.88 -2.25 1.86E-01
5237 BAIAP2L1 222675 s at 4.8919E-02 4.69E-03 2.88 -2.25 1.49E-01
5238 C2orf43 222193 at 4.8919E-02 4.69E-03 2.88 -2.25 2.03E-01
5239 OR10C1 221339 at 4.8933E-02 4.69E-03 2.88 -2.25 1.19E-01
5240 TBC1 D27 233483 at 4.8940E-02 4.69E-03 2.88 -2.25 1.92E-01
5241 ZNF654 241348 at 4.8940E-02 4.69E-03 -2.88 -2.25 -2.26E-01
5242 241641 at 4.8940E-02 4.69E-03 2.88 -2.25 1.11 E-01
5243 GGNBP2 1554419 x at 4.8940E-02 4.69E-03 2.88 -2.25 1.27E-01
5244 SLC01A2 207308 at 4.8997E-02 4.70E-03 2.88 -2.26 1.28 E-01
5245 FKBP14 219390 at 4.8997E-02 4.70E-03 -2.88 -2.26 -4.65E-01
5246 238954 at 4.8997E-02 4.70E-03 2.88 -2.26 1.09E-01
5247 BOK 223349 s at 4.8997E-02 4.70E-03 -2.88 -2.26 -3.60E-01
5248 NUCB1 200646 s at 4.8997E-02 4.70E-03 -2.88 -2.26 -3.22E-01
5249 LRRIQ1 223817 at 4.9031 E-02 4.71 E-03 2.88 -2.26 1.13E-01
5250 ASAM 228082 at 4.9031 E-02 4.71 E-03 -2.88 -2.26 -2.39E-01
5251 PR XP1 235987 at 4.9031 E-02 4.71 E-03 2.88 -2.26 4.04E-01
5252 TCEA2 203919 at 4.9055E-02 4.71 E-03 -2.88 -2.26 -2.82E-01
5253 HIST2H4B/// 208046_at 4.9055E-02 4.71 E-03 2.88 -2.26 1.80E-01 HIST4H4///H
IST2H4A///H
IST1 H4U//H
IST1 H4E///H
IST1 H4B///H
IST1H4H///H
IST1 H4C///H
IST1 H4J///HI
ST1 H4K///HI
ST1 H4F///HI
ST1 H4D///HI
ST1 H4A //HI
ST1 H4I
5254 NFIB 209290 s at 4.9055E-02 4.71 E-03 -2.88 -2.26 -5.71 E-01
5255 ZAK 238613 at 4.9055E-02 4.72E-03 -2.88 -2.26 -2.46E-01
5256 FBXW5 223050 s at 4.9055E-02 4.72E-03 -2.88 -2.26 -3.49E-01
5257 239816 at 4.9073E-02 4.72E-03 2.88 -2.26 1.39E-01
5258 1557551 at 4.9125E-02 4.72E-03 2.88 -2.26 1.79E-01
5259 LOC100132 229748_x_at 4.9169E-02 4.73E-03 -2.88 -2.26 -4.71 E-01 288///LOC72
8312
5260 215978 x at 4.9195E-02 4.73E-03 2.88 -2.26 3.51 E-01
5261 PGRMC2 201701 s at 4.9195E-02 4.73E-03 -2.88 -2.26 -2.70E-01
5262 LOC152578 1564881 at 4.9195E-02 4.73E-03 2.88 -2.26 1.04E-01
5263 HSD3B1 241111 at 4.9208E-02 4.74E-03 2.88 -2.26 1.02E-01
5264 NFIB 209289 at 4.9214E-02 4.74E-03 -2.88 -2.26 -5.23E-01
5265 NR5A2 1560469 at 4.9214E-02 4.74E-03 2.88 -2.26 7.04E-02
5266 SULT1 B1 207601 at 4.9214E-02 4.74E-03 2.88 -2.26 4.39E-01
5267 ATP2C1 209935 at 4.9251 E-02 4.74E-03 -2.88 -2.26 -3.05E-01
5268 CDC25C 205167 s at 4.9254E-02 4.75E-03 2.88 -2.26 2.26E-01
5269 LOC100288 229314_at 4.9256E-02 4.75E-03 2.88 -2.26 1.57E-01 954
5270 FLNA 200859 x at 4.9312E-02 4.75E-03 -2.88 -2.27 -4.09E-01
5271 ODF4 1552409 a at 4.9312E-02 4.75E-03 2.88 -2.27 1.80E-01
5272 MRP63 224535 s at 4.9320E-02 4.76E-03 2.88 -2.27 3.73E-01
5273 SHISA4 226674 at 4.9320E-02 4.76E-03 -2.88 -2.27 -1.86E-01
5274 EZH1 211310 at 4.9351 E-02 4.76E-03 2.88 -2.27 1.25E-01
5275 DIS3L2 238602 at 4.9351 E-02 4.76E-03 2.88 -2.27 2.30E-01
5276 ZNF567 235648 at 4.9377E-02 4.77E-03 2.88 -2.27 3.41 E-01
5277 UBE2Q1 217978 s at 4.9377E-02 4.77E-03 -2.88 -2.27 -3.47E-01
5278 SDCCAG1 1557950 at 4.9408E-02 4.77E-03 -2.88 -2.27 -4.38E-01
103
No. Gene* Probe ID** Adj. p value P value f B Log FC
5279 C6orf108 39817 s at 4.9408E-02 4.77E-03 -2.88 -2.27 -2.02E-01
5280 RAPSN 211570 s at 4.9416E-02 4.77E-03 2.88 -2.27 1.44E-01
5281 SLAMF8 219386 s at 4.9430E-02 4.77E-03 -2.88 -2.27 -4.99E-01
5282 TMIGD2 244716 x at 4.9430E-02 4.78E-03 2.88 -2.27 2.94E-01
5283 RSBN1 222790 s at 4.9434E-02 4.78E-03 2.88 -2.27 3.41 E-01
5284 KCND3 211827 s at 4.9438E-02 4.78E-03 2.88 -2.27 1.10E-01
5285 ZFPL1 214311 at 4.9477E-02 4.78E-03 2.88 -2.27 1.77E-01
5286 LAMP1 201551 s at 4.9481 E-02 4.78E-03 -2.88 -2.27 -5.21 E-01
5287 SLC22A4 205896 at 4.9530E-02 4.79E-03 -2.88 -2.27 -4.29E-01
5288 AFFX- 4.9530E-02 4.79E-03 -2.88 -2.27 -2.83E-01
HUMGAPDH/M3319
GAPDH 7 3 at
5289 KPNB1 213573 at 4.9530E-02 4.79E-03 -2.88 -2.27 -3.04E-01
5290 VRK3 1566700 at 4.9534E-02 4.79E-03 2.88 -2.27 1.44E-01
5291 ANKRD9 230972 at 4.9534E-02 4.79E-03 -2.88 -2.27 -2.98E-01
5292 CSNK2A1 212072 s at 4.9534E-02 4.79E-03 -2.88 -2.27 -3.03E-01
5293 239278 at 4.9534E-02 4.80E-03 2.88 -2.27 3.63E-01
5294 BOLA1 219345 at 4.9543E-02 4.80E-03 2.88 -2.27 2.81 E-01
5295 SP100 202864 s at 4.9563E-02 4.80E-03 2.88 -2.27 2.47E-01
5296 FLJ77644/// 1552302_at 4.9563E-02 4.80E-03 -2.88 -2.27 -2.89E-01 TMEM106A
5297 DHX8 203334 at 4.9570E-02 4.80E-03 -2.88 -2.27 -3.20E-01
5298 MAML3 242794 at 4.9578E-02 4.81 E-03 -2.88 -2.28 -2.28E-01
5299 CDKN1 C 213348 at 4.9578E-02 4.81 E-03 -2.88 -2.28 -6.03E-01
5300 231107 at 4.9578E-02 4.81 E-03 2.88 -2.28 1.47E-01
5301 EXOSC3 227912 s at 4.9578E-02 4.81 E-03 2.88 -2.28 1.70E-01
5302 LOC728099 1561218 s at 4.9578E-02 4.81 E-03 2.88 -2.28 1.18E-01
5303 MRPS15 226296 s at 4.9578E-02 4.81 E-03 2.88 -2.28 3.07E-01
5304 RARRES1 206392 s at 4.9613E-02 4.81 E-03 -2.88 -2.28 -7.55E-01
5305 DPH5 223671 x at 4.9619E-02 4.81 E-03 2.88 -2.28 4.29E-01
5306 LOC283713 230783 at 4.9629E-02 4.82E-03 2.88 -2.28 9.40E-02
5307 NEK2 211080 s at 4.9668E-02 4.82E-03 -2.87 -2.28 -1.62E-01
5308 WIPF2 212051 at 4.9688E-02 4.82E-03 -2.87 -2.28 -3.92E-01
5309 BCL10 1557258 a at 4.9688E-02 4.82E-03 2.87 -2.28 1.70E-01
5310 1569818 at 4.9700E-02 4.83E-03 2.87 -2.28 8.56E-02
531 1 236766 at 4.9700E-02 4.83E-03 2.87 -2.28 2.33E-01
5312 IER3IP1 211406 at 4.9700E-02 4.83E-03 2.87 -2.28 3.20E-01
5313 VPS 13D 220221 at 4.9708E-02 4.83E-03 2.87 -2.28 2.17E-01
5314 1562893 at 4.9708E-02 4.83E-03 2.87 -2.28 1.11 E-01
5315 PNPLA6 203718 at 4.9708E-02 4.83E-03 -2.87 -2.28 -3.71 E-01
5316 WFDC1 219478 at 4.9708E-02 4.83E-03 -2.87 -2.28 -2.40E-01
5317 EPRS 200842 s at 4.9716E-02 4.84E-03 -2.87 -2.28 -3.35E-01
5318 1558337 at 4.9716E-02 4.84E-03 2.87 -2.28 1.29E-01
5319 ATP1 B3 226570 at 4.9716E-02 4.84E-03 -2.87 -2.28 -1.85E-01
5320 234704 at 4.9721 E-02 4.84E-03 2.87 -2.28 1.30E-01
5321 RHBDD2 222995 s at 4.9721 E-02 4.84E-03 -2.87 -2.28 -4.81 E-01
5322 DOK4 209691 s at 4.9721 E-02 4.84E-03 -2.87 -2.28 -2.08E-01
5323 IBSP 207370 at 4.9721 E-02 4.84E-03 2.87 -2.28 1.52E-01
5324 SERPINE1 202628 s at 4.9741 E-02 4.84E-03 -2.87 -2.28 -6.94E-01
5325 241336 at 4.9762E-02 4.85E-03 2.87 -2.28 9.97E-02
5326 215204 at 4.9762E-02 4.85E-03 2.87 -2.28 3.08E-01
5327 PTGS1 238669 at 4.9762E-02 4.85E-03 -2.87 -2.28 -2.89E-01
5328 SNX15///AR 202564_x_at 4.9762E-02 4.85E-03 -2.87 -2.28 -2.55E-01 L2
5329 232576 at 4.9762E-02 4.85E-03 2.87 -2.28 1.34E-01
5330 243332 at 4.9771 E-02 4.85E-03 2.87 -2.28 3.35E-01
5331 LOC100128 232849_at 4.9789E-02 4.85E-03 2.87 -2.28 1.75E-01 988
5332 MAFG 204970 s at 4.9789E-02 4.86E-03 -2.87 -2.28 -2.98E-01
5333 IGFBP7 201163 s at 4.9804E-02 4.86E-03 -2.87 -2.28 -2.60E-01
5334 DEPDC4 1561114 a at 4.9811 E-02 4.86E-03 2.87 -2.28 9.69E-02
5335 PVRL2 203149 at 4.9863E-02 4.87E-03 -2.87 -2.29 -3.05E-01
5336 ERP29 201216 at 4.9863E-02 4.87E-03 -2.87 -2.29 -3.42E-01
5337 RHOBTB3 202975 s at 4.9876E-02 4.87E-03 -2.87 -2.29 -5.52E-01
5338 EVPLL 236933 at 4.9908E-02 4.87E-03 2.87 -2.29 1.13E-01
5339 KIAA1712 231850 x at 4.9916E-02 4.87E-03 2.87 -2.29 2.19E-01
5340 PTAR1 235484 at 4.9955E-02 4.88E-03 2.87 -2.29 3.18E-01
5341 CPSF7 235326 at 4.9958E-02 4.88E-03 2.87 -2.29 8.51 E-02
5342 MCL1 200798 x at 4.9958E-02 4.88E-03 -2.87 -2.29 -3.23E-01
No. Gene* Probe ID** Adj. p value P value f B Log FC
5343 236433 at 4.9983E-02 4.88E-03 2.87 -2.29 1.72E-01
5344 C2orf64 225410 at 4.9996E-02 4.89E-03 2.87 -2.29 4.81 E-01
* Gene symbol as approved by the HUGO gene nomenclature committee (HGNC)
Probe Set ID from Affymetrix GeneChip Human Genome U133 Plus 2.0 array, from Affymetrix Inc, Santa Clara, USA
TABLE B
Biomarkers known or suggested in the art as being of potential diagnostic val differentiating chemotherapy-responsive from chemotherapy-resistant
Hodgkin's lymphoma patients (see ref [34])
UC1 mucin 1 , cell surface associated
SLC47A1 solute carrier family 47, member 1
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2
NT5C2 5'-nucleotidase, cytosolic II
LRRC14 leucine rich repeat containing 14
ZNF581 zinc finger protein 581
FA 166B family with sequence similarity 166, member
B
ASCL1 achaete-scute complex homolog 1
(Drosophila)
CIDEC cell death-inducing DFFA-like effector c
ELM03 engulfment and cell motility 3
FUZ fuzzy homolog (Drosophila)
FGFBP2 fibroblast growth factor binding protein 2
C17orf39 chromosome 17 open reading frame 39
SLIT1 slit homolog 1 (Drosophila)
ABAT 4-aminobutyrate aminotransferase
ANKS1 B ankyrin repeat and sterile alpha motif domain containing 1 B
SAA1 serum amyloid A1 /// serum amyloid A2
ZMAT4 zinc finger, matrin type 4
B3GNT3 UDP-Glc Ac:betaGal beta-1 ,3-N- acetylglucosaminyltransferase 3
MORG1 mitogen-activated protein kinase organizer 1
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene)
SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
ZNF408 zinc finger protein 408
CRCP CGRP receptor component
CLDN7 claudin 7
UTS2R urotensin 2 receptor
PERP PERP, TP53 apoptosis effector
BAIAP2 BAI -associated protein 2
SNAP47 synaptosomal-associated protein, 47kDa
FLJ40125 hypothetical protein FLJ40125
G0SR2 Golgi SNARE (GS27)
CENPO centromere protein 0
INK1 misshapen-like kinase 1 (zebrafish)
COMT catechol-O-methyltransferase
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
RC3H2 ring finger and CCCH-type zinc finger
domains 2
STAGE
N NAT1 nicotinamide nucleotide adenylyltransferase 1
HSDL1 hydroxysteroid dehydrogenase like 1
POLR2J4 polymerase (RNA) II (DNA directed)
polypeptide J4, pseudogene
ANKRD26 ankyrin repeat domain 26
CDYL chromodomain protein, Y-like
CCDC151 coiled-coil domain containing 151
SLC4A11 solute carrier family 4, sodium borate
transporter, member 1 1
PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide
STAP2 signal transducing adaptor family member 2
MDFIC MyoD family inhibitor domain containing
NCRNA00105 non-protein coding RNA 105
PERP PERP, TP53 apoptosis effector
LOC751071 methyltransferase LOC751071 , mitochondrial- like
ANGPTL4 angiopoietin-like 4
SHBG sex hormone-binding globulin
PKP1 plakophilin 1 (ectodermal dysplasia/skin
fragility syndrome)
RNF144B CDNA FLJ59797 complete cds, highly similar to E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-)
GTF3C4 general transcription factor NIC, polypeptide 4,
90kDa
COL1 1A2 collagen, type XI, alpha 2
i Ί 3
TABLE C
Exemplary biomarker signature of 15 gene biomarkers differentially expressed between chemotherapy resistant and sensitive Hodgkin's lymphoma patients
(a) Zinc finger protein 644 (ZNF644) ;
(b) Colipase, pancreatic (CLPS) ;
(c) EST tu05b03.x1 ;
(d) relaxin 1 (RLN1);
(e) phosphodiesterase 6D, cGMP-specific, rod, delta (PDE6D);
(f) EMI domain containing 2 (EMID2);
(g) heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa; HSPA5));
(h) spermatogenesis associated 12 (SPATA12);
(i) kinectin 1 (kinesin receptor; KTN1);
(j) pentraxin 3, long (PTX3);
(k) erythropoietin receptor (EPOR);
(I) DC-STAMP domain containing 2 (DCST2);
(m) golgi to ER traffic protein 4 homolog {S. cerevisiae; GET4);
(n) mitogen-activated protein kinase 14 (MAPK14); and
(o) chromosome 1 open reading frame 163 (C1 orf163).
TABLE D
Statistical overview of gene biomarkers identified as being differentially expressed between chemotherapy resistant and sensitive Hodgkin's lymphoma patients (atypical "outlier" group)
No. Gene* Probe ID** Adj. p value P value t B Log FC
1 CD93 202877 s at 0.000133 2.43E-09 11.65 10.77 1.78436
2 GJD3 230025 at 0.000167 6.10E-09 10.94 10.04 1.41240
3 PRRX1 205991 s at 0.000747 4.10E-08 9.57 8.49 1.75162
4 NRP1 210510 s at 0.001086 7.94E-08 9.13 7.93 1.27260
5 CYGB 226632 at 0.001243 1.18E-07 8.87 7.59 1.05169
6 GGT5 205582 s at 0.001243 1.36E-07 8.78 7.47 1.91095
7 COL6A2 213290 at 0.001363 2.10E-07 8.50 7.10 2.06811
8 LAPTM4B 208767 s at 0.001363 2.11 E-07 8.50 7.10 1.66799
9 DDAH1 209094 at 0.001363 2.24E-07 8.46 7.04 1.60410
10 ZDHHC9 222451 s at 0.001467 2.68E-07 8.35 6.89 1.16314
11 GNAQ 224861 at 0.001592 3.20E-07 8.24 6.73 1.35432
12 NRP1 212298 at 0.001888 4.14E-07 8.08 6.51 2.36720
13 CD209 207277 at 0.00211 5.46E-07 7.91 6.27 3.03822
14 CD59 212463 at 0.00211 5.59E-07 7.90 6.25 1.44157
15 APLP2 208703 s at 0.00211 5.79E-07 7.88 6.22 1.47862
16 FOSL2 225262 at 0.002128 6.44E-07 7.82 6.12 1.80222
17 PARVA 217890 s at 0.002128 7.36E-07 7.74 6.00 1.59587
18 CTNNA1 1558214 s at 0.002128 7.64E-07 7.71 5.97 1.13446
19 KLF11 218486_at 0.002128 7.75E-07 7.70 5.96 1.40943
20 CYP1 B1 202436 s at 0.002128 7.97E-07 7.69 5.93 1.78844
21 COL6A1 212091 s at 0.002128 8.25E-07 7.67 5.90 2.16408
22 FAM198B 219872 at 0.002128 8.85E-07 7.63 5.84 1.17368
23 ATRN 211852 s at 0.002128 9.30E-07 7.60 5.80 1.27690
24 LAMP1 201551 s at 0.002128 9.34E-07 7.60 5.79 1.61768
25 TRAM2 202368 s at 0.002358 1.08E-06 7.51 5.66 1.17145
26 YAP1 224895 at 0.002492 1.19E-06 7.46 5.58 1.62591
27 SOX13 38918 at 0.002807 1.46E-06 7.34 5.39 0.61378
28 RHBDD2 232053 x at 0.002807 1.46E-06 7.34 5.39 1.16409
29 C1 R 212067_s_at 0.002807 1.49E-06 7.32 5.38 2.11216
30 BACE2 222446 s at 0.003058 1.68E-06 7.26 5.27 1.41917
31 NBL1 37005_at 0.003308 1.92E-06 7.18 5.15 1.66252
32 1TSN1 209297 at 0.003308 2.00E-06 7.16 5.11 1.33423
33 EPDR1 223253 at 0.003308 2.04E-06 7.15 5.10 1.86142
34 TMC03 220240 s at 0.003308 2.06E-06 7.14 5.09 0.74084
35 EMILIN1 204163 at 0.003443 2.24E-06 7.09 5.01 2.15345
36 236297 at 0.003443 2.27E-06 7.09 5.00 1.24898
37 LAPTM4B 1554679 a at 0.003739 2.53E-06 7.02 4.90 1.48330
38 CLIC4 201559 s at 0.003934 2.82E-06 6.96 4.80 1.53854
39 235072 s at 0.003934 2.84E-06 6.96 4.80 1.24865
40 NR2F2 215073 s at 0.003934 2.88E-06 6.95 4.78 1.91316
41 ADAM9 1555326 a at 0.004066 3.05E-06 6.92 4.73 1.19432
42 CYP1 B1 202435 s at 0.004163 3.23E-06 6.89 4.68 1.69770
43 235438 at 0.004163 3.27E-06 6.88 4.67 1.33093
44 MEM01 219065 s at 0.004556 3.67E-06 -6.82 4.57 -0.70693
45 TUSC3 209228 x at 0.004638 3.87E-06 6.79 4.52 0.80020
46 FOSL2 218880 at 0.004638 4.07E-06 6.76 4.47 1.53982
47 TGM2 201042 at 0.004638 4.22E-06 6.74 4.44 2.97901
48 MPZL1 201874 at 0.004638 4.30E-06 6.73 4.42 1.14039
49 NBL1 201621 at 0.004638 4.37E-06 6.72 4.41 1.36420
50 SLC2A10 221024 s at 0.004638 4.40E-06 6.72 4.40 2.05135
51 KLF7 1555420 a at 0.004638 4.41 E-06 6.72 4.40 1.05220
52 APLP2 214875 x at 0.004638 4.41 E-06 6.71 4.40 1.40270
53 ETS2 201329 s at 0.005309 5.15E-06 6.63 4.26 1.10204
54 TIMP2 224560 at 0.005474 5.43E-06 6.60 4.21 2.58750
55 PiCALM 215236 s at 0.005474 5.51 E-06 6.59 4.20 1.90895
56 NR2F2 209121 x at 0.005509 5.64E-06 6.58 4.17 1.61550
57 NHSL1 226490 at 0.005738 6.08E-06 6.54 4.11 1.14567
58 KANK2 218418 s at 0.005738 6.35E-06 6.52 4.07 1.69799
59 RHOJ 235489 at 0.005738 6.44E-06 6.51 4.05 1.63481
60 FZD2 210220 at 0.005738 6.46E-06 6.51 4.05 1.56233
61 RHOBTB3 202975 s at 0.005738 6.50E-06 6.50 4.04 1.45826
62 EGFR 201983 s at 0.005738 6.51 E-06 6.50 4.04 1.40950
Gene* Probe ID** Adj. p value P value t B Log FC
ITSN1 209298 s at 0.005924 6.83E-06 6.48 4.00 1.40938
RHOBTB1 212651 at 0.006269 7.44E-06 6.43 3.92 1.23840
GNA11 564_at 0.006269 7.45E-06 6.43 3.92 1.05358
ARSB 206129 s at 0.006345 7.75E-06 6.41 3.88 0.77367
OLFML3 218162 at 0.006345 7.81 E-06 6.40 3.88 2.68363
SETD7 224928 at 0.006345 7.89E-06 6.40 3.87 1.19914
CPX 1 227860 at 0.006379 8.05E-06 6.39 3.85 2.11441
CD99L2 233825 s at 0.006394 8.49E-06 6.36 3.80 0.92238
LHFP 218656 s at 0.006394 8.58E-06 6.35 3.79 1.43285
EFE P2 209356_x_at 0.006394 8.63E-06 6.35 3.79 1.83770
RHOJ 238905_at 0.006394 8.65E-06 6.35 3.78 0.97934
GAS6 202177 at 0.006394 8.74E-06 6.35 3.78 1.64885
HLX 214438 at 0.006394 8.77E-06 6.34 3.77 0.90944
MMP19 204575 s at 0.006436 8.95E-06 6.33 3.75 1.34431
FKBP9 212169 at 0.00648 9.13E-06 6.32 3.74 1.60759
PVRL2 203149 at 0.006594 9.60E-06 6.30 3.69 0.85490
PCYOX1 225274 at 0.006594 9.64E-06 6.29 3.68 1.47245
C6orf115 223361 at 0.006594 9.72E-06 -6.29 3.68 -1.10617
CDC42BPB 217849 s at 0.006594 9.87E-06 6.28 3.66 1.36892
SG S2 227038 at 0.006594 9.90E-06 6.28 3.66 1.05480
228827 at 0.006594 1.01 E-05 6.27 3.65 1.62794
CTTN 227473 at 0.006594 1.01 E-05 6.27 3.64 1.26328
CXCL12 203666 at 0.006611 1.03E-05 6.26 3.63 2.20517
BACE2 217867 x at 0.006747 1.06E-05 6.24 3.60 1.57668
RBPJ 21 974 x at 0.006785 1.08E-05 6.23 3.58 0.76464
CYP1B1 202437 s at 0.006795 1.09E-05 6.23 3.57 1.59943
CALU 200756_x_at 0.006833 1.13E-05 6.21 3.54 1.35976
PCYOX1 203803 at 0.006833 1.14E-05 6.20 3.53 1.38877
TUSC3 213423 x at 0.006833 1.14E-05 6.20 3.53 1.19659
FLJ 10357 58780 s at 0.006833 1.18E-05 6.18 3.50 1.27761
CD59 228748 at 0.006833 1.19E-05 6.18 3.49 0.94860
ITGA 205786 s at 0.006833 1.21 E-05 6.17 3.47 1.87159
LOC653506/ 0.006833 6.17 3.47
// ETRNL 225955 at 1.21 E-05 2.20700
ORC6L 219105 x at 0.006833 1.21 E-05 -6.17 3.47 -0.96712
QKI 212263 at 0.006833 1.22E-05 6.17 3.47 0.75189
PDGFA 205463 s at 0.006833 1.23E-05 6.16 3.46 1.46231
L NA 1554600 s at 0.006833 1.24E-05 6.16 3.46 1.49165
DDR2 227561 at 0.006969 1.27E-05 6.14 3.43 1.65447
ASPH 225008 at 0.007334 1.35E-05 6.11 3.37 1.37303
NFIC 213298 at 0.007357 1.37E-05 6.11 3.36 1.03719
FER T2 209209 s at 0.007375 1.40E-05 6.10 3.34 1.54988
FA 46A 224973 at 0.007375 1.40E-05 6.09 3.34 0.96297
FBLN1 202995 s at 0.007458 1.43E-05 6.08 3.32 2.36742
S TN 207390 s at 0.007785 1.51 E-05 6.06 3.27 0.76786
DDAH2 214909 s at 0.007858 1.54E-05 6.05 3.26 1.03052
SOD3 205236 x at 0.008021 1.59E-05 6.03 3.23 0.88354
PCS 5 205560 at 0.008021 1.60 E-05 6.03 3.22 1.51703
CTNNA1 210844 x at 0.008141 1.64E-05 6.01 3.20 0.95725
CAV1 203065 s at 0.008405 1.71 E-05 5.99 3.16 1.59793
CYBRD1 217889 s at 0.008466 1.73E-05 5.98 3.15 1.41438
PARVA 222454 s at 0.008466 1.80E-05 5.96 3.11 1.49183
EHD2 45297 at 0.008466 1.80E-05 5.96 3.11 1.30821
IGFBP2 202718 at 0.008466 1.81 E-05 5.96 3.11 1.77981
GLT25D1 222644 s at 0.008466 1.81 E-05 5.96 3.11 0.94005
LRP11 225060 at 0.008466 1.81 E-05 5.96 3.10 1.51269
TNS1 218864 at 0.008466 1.83E-05 5.96 3.10 0.55614
RPS19 242451 x at 0.008491 1.85E-05 -5.95 3.08 -0.71207
ZNF697 227080 at 0.008491 1.88E-05 5.94 3.07 1.32974
SH3PXD2B 231823 s at 0.008491 1.89E-05 5.94 3.07 1.93061
PICALM 215832 x at 0.008491 1.89E-05 5.94 3.06 0.80706
ISLR 207191 s at 0.008667 1.96E-05 5.92 3.03 1.38492
DIAPH2 205726 at 0.008667 1.97E-05 592 3.03 1.07735
PBX1 212151 at 0.008685 2.01 E-05 5.91 3.01 1.02339
PDGFRB 202273 at 0.008685 2.03E-05 5.90 3.00 1.22179
CUX1 202367 at 0.008685 2.05E-05 5.90 2.99 1.00412
KC D3 213832 at 0.008685 2.06E-05 5.89 2.99 0.87689
RGS5 209070 s at 0.008685 2.11 E-05 5.88 2.97 1.92764
LDLRAD3 234985 at 0.008685 2.11 E-05 5.88 2.97 0.97940
No. Gene* Probe ID** Adj. p value P value ί B Log FC
131 FAM46A 221766 s at 0.008685 2.14E-05 5.87 2.95 1.28303
132 LMAN1 203293 s at 0.008685 2.15E-05 5.87 2.95 0.99215
133 1558397 at 0.008685 2.16E-05 5.87 2.94 1.08220
134 OSMR 205729 at 0.008685 2.19E-05 5.86 2.93 0.91495
135 EEF2K 225545 at 0.008685 2.21 E-05 5.86 2.92 0.95197
136 CD93 202878 s at 0.008685 2.21 E-05 5.86 2.92 2.65424
137 ICAM1 202637 s at 0.008685 2.22E-05 5.86 2.92 1.51536
138 S100A16 227998 at 0.008685 2.23E-05 5.85 2.91 1.33254
139 DDAH2 215537 x at 0.008685 2.24E-05 5.85 2.91 0.97510
140 C13orf33 227058 at 0.008685 2.24E-05 5.85 2.91 1.43508
141 FAM13A 217047 s at 0.008685 2.26E-05 5.85 2.90 1.39577
142 SOCS5 209647 s at 0.008685 2.26E-05 5.85 2.90 1.25521
143 WLS 228950 s at 0.008685 2.27E-05 5.84 2.90 0.72634
1 4 ZBTB47 226484 at 0.008685 2.29E-05 5.84 2.89 0.58401
145 CD52 204661 at 0.008685 2.30E-05 -5.84 2.88 -1.33174
146 DUT 208956 x at 0.00869 2.36E-05 -5.82 2.86 -0.64165
147 FBLN1 201787 at 0.00869 2.36E-05 5.82 2.86 2.15652
148 F13A1 203305 at 0.00869 2.38E-05 5.82 2.86 2.66507
149 CYB561 209163 at 0.00869 2.39E-05 5.82 2.85 0.93242
150 FAM109B 226504 at 0.00869 2.40E-05 5.82 2.85 0.85477
151 FPR3 230422 at 0.00869 2.41 E-05 5.81 2.84 2.00221
152 SEL1 L 202062 s at 0.00869 2.42E-05 5.81 2.84 1.04260
153 LRRC32 203835 at 0.00869 2.44E-05 5.81 2.83 1.53810
154 ME1S1 204069_at 0.00869 2.46E-05 5.80 2.82 1.59094
155 GOLM1 217771_at 0.00869 2.46E-05 5.80 2.82 1.63895
156 STON1 213413 at 0.008943 2.55E-05 5.78 2.79 1.59975
157 238455 at 0.009112 2.52E-05 5.77 2.77 1.10975
158 ZNF680 229533 x at 0.009433 2.73E-05 -5.75 2.73 -0.82784
159 ETS2 201328 at 0.009595 2.79E-05 5.74 2.71 1.03272
160 FPR3 214560 at 0.009649 2.82E-05 5.73 2.70 1.04589
161 GPR124 221814 at 0.009649 2.84E-05 5.73 2.69 1.26234
162 XD1 226275 at 0.009737 2.88E-05 5.72 2.68 1.32163
163 GNG12 212294_at 0.009815 2.94E-05 5.71 2.66 1.21488
164 APLP2 208702 x at 0.009815 2.96E-05 5.71 2.65 1.37660
165 FRMD4A 225163 at 0.009815 2.98E-05 5.71 2.65 1.54531
166 TR1M2 202342 s at 0.009815 2.98E-05 5.70 2.65 0.78730
167 QKl 1555154 a at 0.009818 3.00E-05 5.70 2.64 1.19311
168 RBM9 213901 x at 0.010296 3.16E-05 5.67 2.59 1.04619
169 CDKN1 C 213348 at 0.010416 3.22E-05 5.67 2.57 1.49140
170 HIST3H2A 221582 at 0.010445 3.27E-05 -5.66 2.56 -1.00740
171 ARSD 225286 at 0.010445 3.28E-05 5.66 2.56 0.84876
172 CLDN23 228707 at 0.010445 3.30E-05 5.65 2.55 0.88032
173 B4GALT1 216627 s at 0.010445 3.30E-05 5.65 2.55 1.38511
174 RHOBTB3 202976 s at 0.010501 3.34E-05 5.65 2.54 1.99528
175 YOF 211864 s at 0.010657 3.41 E-05 5.64 2.52 2.03275
176 EMP2 225078 at 0.010851 3.49E-05 5.62 2.50 1.41779
177 H1 F0 208886 at 0.010856 3.52E-05 5.62 2.49 0.76660
178 BMP1 205574 x at 0.010856 3.54E-05 5.62 2.49 1.36052
179 DDAH2 202262 x at 0.010856 3.55E-05 5.62 2.48 0.82051
180 APP 214953 s at 0.01099 3.62E-05 5.61 2.47 1.65885
181 RXRA 202449 s at 0.011137 3.69E-05 5.60 2.45 0.91932
182 CTNNA1 200765 x at 0.011171 3.72E-05 5.59 2.44 1.31830
183 MXRA7 227326 at 0.011388 3.84E-05 5.58 2.41 0.99302
184 O A1 226019 at 0.011388 3.87E-05 -5.57 2.40 -0.83291
185 SEC61A1 217716 s at 0.011388 3.88E-05 5.57 2.40 0.94550
186 THBD 203888 at 0.011388 3.93E-05 5.56 2.39 1.60870
187 PLAT 201860 s at 0.011388 3.93E-05 5.56 2.39 1.15767
188 DDR2 225442 at 0.011388 3.95E-05 5.56 2.38 1.99006
189 SYNPO 202796 at 0.011388 3.95E-05 5.56 2.38 1.22663
190 FGD4 227948 at 0.011388 3.96E-05 5.56 2.38 1.12858
191 CDH5 204677 at 0.011628 4.08E-05 5.55 2.35 1.73119
192 AKAP12 227530 at 0.011628 4.08E-05 5.54 2.35 1.56308
193 GAB2 203853 s at 0.011639 4.11 E-05 5.54 2.35 0.92120
194 PCOLCE 202465 at 0.011653 4.15E-05 5.54 2.34 2.13140
195 FAP4 212713 at 0.011653 4.18E-05 5.53 2.33 1.81941
196 DUT 209932 s at 0.011653 4.20E-05 -5.53 2.33 -0.70971
197 H1C1 230218 at 0.011653 4.20E-05 5.53 2.33 0.83006
198 PPAP2B 209355 s at 0.011739 4.25E-05 5.52 2.32 2.48236
199 1GFBP4 201508 at 0.011739 4.27E-05 5.52 2.31 2.03859
No. Gene* Probe ID** Adj. p value P value t B Log FC
200 FILIP1 1556325 at 0.011813 4.34E-05 5.51 2.30 0.62596
201 CHST15 203066 at 0.011813 4.36E-05 5.51 2.29 1.71789
202 CALC L 210815 s at 0.011813 4.36E-05 5.51 2.29 1.39867
203 OLFML1 217525 at 0.01203 4.49E-05 5.50 2.26 1.58697
204 ABCA7 219577 s at 0.01203 4.51 E-05 -5.50 2.26 -0.70510
205 SPINT1 202826 at 0.01203 4.53E-05 5.49 2.26 0.63954
206 SELENBP1 214433 s at 0.01203 4.54E-05 5.49 2.25 0.76556
207 SLC27A1 226728 at 0.01203 4.57E-05 5.49 2.25 0.75714
208 APLP2 211404 s at 0.01203 4.58E-05 5.49 2.25 1.32743
209 ZCCHC24 212419 at 0.01203 4.61 E-05 5.48 2.24 1.11235
210 HGSNAT 218017 s at 0.01203 4.62E-05 5.48 2.24 1.19776
211 SOX7 228698 at 0.012093 4.67E-05 5.48 2.23 1.08037
212 CTBP2 201218 at 0.012151 4.71 E-05 5.47 2.22 0.81510
213 COL4A2 211966 at 0.012387 4.83E-05 5.46 2.20 2.29284
214 MPZL1 210087 s at 0.012502 4.92E-05 5.45 2.18 1.08920
215 GPRC5B 203632 s at 0.012502 4.94E-05 5.45 2.18 1.16904
216 EPB41L3 206710 s at 0.012502 4.95E-05 5.45 2.17 2.23007
217 NID1 202008 s at 0.012502 4.96E-05 5.45 2.17 1.35116
218 MTUS1 212093 s at 0.012557 5.10E-05 5.43 2.15 0.60686
219 PTGFRN 224937 at 0.012557 5.10E-05 5.43 2.15 2.14241
220 RIN3 219457 s at 0.012557 5.10E-05 5.43 2.15 0.80367
221 JAM2 219213 at 0.012557 5.13E-05 5.43 2.14 1.43856
222 MEIS2 207480 s at 0.012557 5.14E-05 5.43 2.14 1.20710
223 PDE4A 204735 at 0.012557 5.14E-05 5.43 2.14 1.32080
224 CRAT 209522 s at 0.012557 5.15E-05 5.43 2.14 0.89415
225 ARMCX2 203404 at 0.012557 5.17E-05 5.43 2.13 1.70933
226 PTGS1 215813 s at 0.012756 5.27E-05 5.42 2.12 1.99888
227 C5orf33 226946 at 0.012803 5.32E-05 5.41 2.11 0.56872
228 FNDC3B 222693 at 0.012854 5.36E-05 5.41 2.10 1.23266
229 THBS1 201108 s at 0.012949 5.42E-05 5.40 2.09 1.49923
230 CALU 214845 s at 0.01322 5.56E-05 5.39 2.07 1.67680
231 C2orf18 225695 at 0.013232 5.59E-05 5.39 2.06 1.05388
232 NTRK2 221795 at 0.013249 5.65E-05 5.38 2.05 1.92837
233 UGDH 203343 at 0.013249 5.70E-05 5.38 2.04 0.94878
234 RILPL1 226207 at 0.013249 5.72E-05 5.38 2.04 0.69112
235 BACE1 222463 s at 0.013249 5.76E-05 5.37 2.03 0.62972
236 TSTD1 226482 s at 0.013249 5.76E-05 -5.37 2.03 -1.20394
237 CR1SPLD2 221541 at 0.013249 5.76E-05 5.37 2.03 2.91342
238 NDUFB1 206790 s at 0.013249 5.79E-05 -5.37 2.03 -0.66179
239 EDNRB 206701 x at 0.013249 5.83E-05 5.37 2.02 1.22319
240 EPB41 L2 201718 s at 0.013249 5.86E-05 5.36 2.02 1.05785
241 MYL9 201058 s at 0.013249 5.88E-05 5.36 2.01 2.27247
242 SLC7A8 216092 s at 0.013249 5.89E-05 5.36 2.01 0.82050
243 CD52 34210 at 0.013249 5.89E-05 -5.36 2.01 -1.45689
244 PLTP 202075 s at 0.013267 5.93E-05 5.36 2.01 2.99379
245 PLXDC2 227276 at 0.013267 5.96E-05 5.35 2.00 1.51326
246 MY01 C 225080 at 0.013267 5.97E-05 5.35 2.00 1.31923
247 RUSC1 206949 s at 0.013274 6.00E-05 5.35 2.00 0.82343
248 225567 at 0.013274 6.04E-05 5.35 1.99 1.69691
249 APBB2 213419 at 0.013274 6.05E-05 5.35 1.99 0.45946
250 CCDC3 223316 at 0.013848 6.33E-05 5.32 1.95 1.44258
251 C0L4A1 211981 at 0.013979 6.45E-05 5.32 1.93 2.47763
252 EL0VL5 215082 at 0.013979 6.45E-05 -5.32 1.93 -1.29501
253 FMOD 202709 at 0.013979 6.47E-05 5.31 1.93 1.77245
254 ANGPTL2 213001 at 0.014043 6.54E-05 5.31 1.92 2.04438
255 ARVELD1 223095 at 0.014043 6.55E-05 5.31 1.91 1.03576
256 ITM2A 202746 at 0.014054 6.58E-05 -5.31 1.91 -1.30118
257 PALMD 218736 s at 0.014347 6.74E-05 5.29 1.89 1.26220
258 PPP1 R3B 222662 at 0.014494 6.84E-05 5.29 1.87 0.95412
259 EXT1 201995 at 0.014494 6.87E-05 5.28 1.87 0.64811
260 TGOLN2 212040 at 0.014514 6.90E-05 5.28 1.87 1.90875
261 ACOX3 204242 s at 0.01453 6.95E-05 5.28 1.86 0.48199
262 HIP1 226364 at 0.01453 6.97E-05 5.28 1.86 1.22830
263 FOSL2 228188 at 0.01453 6.99E-05 5.28 1.85 1.65567
264 1FNAR1 225661 at 0.01467 7.08E-05 5.27 1.84 1.29931
265 RHBDF1 218686 s at 0.014709 7.14E-05 5.27 1.83 0.77780
266 MARCKS 213002 at 0.014709 7.16E-05 5.26 1.83 0.84506
267 ANO10 218910 at 0.014809 7.28E-05 5.26 1.82 1.00844
268 MCAM 209086 x at 0.014809 7.29E-05 5.26 1.81 0.84422
1 !9
No. Gene* Probe ID** Adj. p value P value f B Log FC
338 COL6A1 213428 s at 0.017426 1.08E-04 5.06 1.45 2.63585
339 LOXL1 203570 at 0.017426 1.08E-04 5.06 1.45 2.07400
340 242057 at 0.017426 1.09E-04 -5.06 1.44 -0.41478
341 TMEM164 223202 s at 0.017426 1.09E-04 5.06 1.44 0.53937
342 PAPSS2 203059 s at 0.017426 1.09E-04 5.05 1.44 0.81608
343 ZCCHC24 212423 at 0.017426 1.10E-04 5.05 1.44 1.41043
344 GNA11 204248 at 0.017426 1.10E-04 5.05 1.43 1.19160
345 CANX 208852 s at 0.017426 1.10E-04 5.05 1.43 1.72011
346 PTRF 208789 at 0.017426 1.10E-04 5.05 1.43 1.40029
347 NFIA 224976_at 0.017426 1.11 E-04 5.05 1.43 1.10291
348 KLF4 221841 s at 0.017472 1.11 E-04 5.05 1.42 1.78540
349 TPBG 203476 at 0.017516 1.12E-04 5.04 1.42 1.55583
350 COL6A2 209156_s_at 0.017574 1.13E-04 5.04 1.41 3.49238
351 FOX03 204132 s at 0.017574 1.13E-04 5.04 1.41 1.01826
352 LOC643749 240577 at 0.017605 1.13E-04 -5.04 1.40 -0.37339
353 ATPIF1 223338 s at 0.017687 1.14E-04 -5.03 1.40 -0.63610
354 ARMCX3 222444 at 0.017772 1.15E-04 5.03 1.39 0.71533
355 SLC2A14/// 0.017831 5.03 1.38
SLC2A3 222088 s at 1.16E-04 1.27193
356 AK3L2///AK4 225342 at 0.017833 1.16E-04 5.03 1.38 1.44204
357 AH AK 220016 at 0.017876 1.17E-04 5.02 1.38 0.51771
358 SHE 229910 at 0.017889 1.18E-04 5.02 1.37 1.00955
359 STAT3 208992 s at 0.017889 1.18E-04 5.02 1.37 1.07618
360 ALDH7A1 208951 _at 0.017889 1.18E-04 5.02 1.37 0.75761
361 231431 s at 0.017889 1.18E-04 5.02 1.36 0.88133
362 RAB31 217762 s at 0.017889 1.18E-04 5.02 1.36 1.80370
363 DVL3 201908 at 0.01792 1.19E-04 5.01 1.36 1.07444
364 FNIP1 228768 at 0.017957 1.20E-04 5.01 1.35 0.51862
365 PAPSS2 203058 s at 0.017994 1.21 E-04 5.01 1.35 1.40271
366 SLC03A1 219229 at 0.017994 1.21 E-04 5.01 1.34 1.13595
367 TBC D16 222116 s at 0.017994 1.21 E-04 5.01 1.34 1.47527
368 CDH11 207172 s at 0.01803 1.22E-04 5.00 1.34 1.55766
369 DUSP3 201537 s at 0.01803 1.22E-04 5.00 1.34 1.08205
370 ZCCHC10 1559399 s at 0.01803 1.23E-04 -5.00 1.33 -1.34448
371 CTNNA1 200764 s at 0.01803 1.23E-04 5.00 1.33 1.40287
372 ZBTB8B///Z 0.01803 5.00 1.33
BTB8A 235142 at 1.23E-04 0.99405
373 NPNT 225911 at 0.018074 1.23E-04 5.00 1.32 0.89136
374 PLSCR4 218901 at 0.018127 1.24E-04 4.99 1.32 1.56589
375 SLC16A3 202855 s at 0.018281 1.25E-04 4.99 1.31 1.35624
376 PLXND1 212235 at 0.018281 1.26E-04 4.99 1.31 1.12153
377 RPS7 213941 x at 0.018694 1.29E-04 -4.97 1.28 -0.45270
378 DPYSL3 201430 s at 0.018694 1.30E-04 4.97 1.28 1.04857
379 TNFAIP1 201207 at 0.018694 1.30E-04 4.97 1.28 1.39587
380 TK2 204277 s at 0.018694 1.30E-04 4.97 1.27 0.59353
381 RUNX1T1 205528 s at 0.018694 1.30E-04 4.97 1.27 1.15458
382 CNIH4 228306 at 0.018694 1.31 E-04 4.97 1.27 0.69238
383 ANKRD16 229058 at 0.018697 1.31 E-04 4.97 1.27 0.54640
384 CNRIP1 226751 at 0.0187 1.32E-04 4.96 1.26 1.19577
385 MTSS1 203037 s at 0.0187 1.32E-04 4.96 1.26 0.61428
386 CD69 209795 at 0.018797 1.33E-04 -4.96 1.25 -1.29777
387 ZNF410 209944 at 0.018797 1.33E-04 -4.96 1.25 -0.56501
388 TRIP6 209129 at 0.018797 1.34E-04 4.96 1.25 1.38554
389 MEIS3P1 214077 x at 0.018797 1.34E-04 4.96 1.25 0.82309
390 AP2A2 211779 x at 0.018797 1.34E-04 4.96 1.25 1.60298
391 CPE 201116 s at 0.019012 1.36E-04 4.95 1.23 1.62813
392 HIBADH 231955 s at 0.019012 1.36E-04 4.95 1.23 0.45055
393 GALNTL4 1554079 at 0.019096 1.37E-04 4.94 1.22 0.51687
394 PALM2- 0.01912 4.94 1.22
AKAP2 //PA
LM2///AKAP
2 202759 s at 1.38E-04 1.55920
395 TTC28 215146 s at 0.019168 1.39E-04 4.94 1.21 0.93348
396 SIPA1 L2 225056 at 0.019168 1.39E-04 4.94 1.21 1.14353
397 MLEC 200617 at 0.019168 1.39E-04 4.94 1.21 1.24515
398 NID1 202007 at 0.019204 1.40E-04 4.93 1.21 2.21449
399 SCAMP1 1552978 a at 0.019389 1.42E-04 4.93 1.19 1.01787
400 SOX 18 219568 x at 0.019389 1.43E-04 4.92 1.19 0.65010
401 AOC3 204894 s at 0.019389 1.43E-04 4.92 1.19 1.56693
No. Gene* Probe ID** Adj. p value P value f B Log FC
402 FDFT1 208647 at 0.019389 1.44E-04 -4.92 1.18 -0.75026
403 C1S 208747 s at 0.019389 1.44E-04 4.92 1.18 1.18557
404 CAV1 212097 at 0.019389 1.44E-04 4.92 1.18 1.62217
405 LAPTM4B 208029 s at 0.019389 1.44E-04 4.92 1.18 1.36621
406 FNTB 225851 at 0.019389 1.45E-04 4.92 1.18 0.89961
407 CFI 203854 at 0.019389 1.45E-04 4.92 1.17 1.93698
408 ADAMTS2 214454 at 0.019389 1.45E-04 4.92 1.17 1.15908
409 RHOJ 1555233 at 0.019389 1.45E-04 4.92 1.17 0.81778
410 RBPMS 209488 s at 0.019389 1.45E-04 4.92 1.17 2.00388
411 PPP3CC 32541 at 0.019664 1.48E-04 -4.91 1.15 -0.80049
412 RASIP1 220027 s at 0.019664 1.48E-04 4.91 1.15 1.06921
413 DLEU1 205677 s at 0.019664 1.49E-04 -4.90 1.15 -1.06111
414 CRK 202226 s at 0.019664 1.49E-04 4.90 1.15 1.15821
415 PDLIM4 211564 s at 0.019708 1.50E-04 4.90 1.14 1.12666
416 TM9SF4 212194 s at 0.02002 1.52E-04 4.89 1.13 1.51469
417 EPAS1 200878 at 0.020186 1.54E-04 4.89 1.12 1.67703
418 GNA14 220108 at 0.020186 1.54E-04 4.89 1.11 1.03741
419 EDNRA 204464 s at 0.020186 1.55E-04 4.89 1.11 2.05317
420 TMEM164 223201 s at 0.020219 1.55E-04 4.88 1.11 0.64543
421 ITPRIPL2 1568619 s at 0.020254 1.56E-04 4.88 1.10 1.45563
422 FCGR2A 203561 at 0.020254 1.56E-04 4.88 1.10 2.45521
423 FAM36A 224824 at 0.020254 1.57E-04 -4.88 1.10 -0.67072
424 GALNS 206335 at 0.020368 1.58E-04 4.88 1.09 0.91252
425 KIAA1731 229878_at 0.020394 1.59E-04 -4.87 1.09 -0.74840
426 213710 s at 0.020394 1.59E-04 4.87 1.09 0.75617
427 SERPINH1 207714 s at 0.020401 1.60E-04 4.87 1.08 2.31674
428 INPP5B 213804 at 0.020401 1.60E-04 -4.87 1.08 -0.50110
429 MARS 213671 s at 0.020401 1.61 E-04 -4.87 1.08 -0.66973
430 ZFAND3 218020 s at 0.020401 1.61 E-04 4.87 1.07 0.86627
431 MARCO 205819_at 0.020401 1.62E-04 4.86 1.07 2.21337
432 QSOX1 201482 at 0.020401 1.62E-04 4.86 1.07 0.77022
433 TIMP2 231579_s_at 0.020401 1.62E-04 4.86 1.07 2.45433
434 CH25H 206932 at 0.020401 1.62E-04 4.86 1.07 1.76980
435 C1QTNF5/// 0.020414 4.86 1.07
MFRP 223499_at 1.62E-04 1.46979
436 RHOC 200885 at 0.020414 1.63E-04 4.86 1.06 1.20795
437 ARHGAP23 226638 at 0.02043 1.64E-04 4.86 1.06 0.82255
438 242316 at 0.02043 1.64E-04 -4.86 1.06 -0.43281
439 CTTNBP2N 0.020463 4.86 1.06
L 226000 at 1.64E-04 0.93642
440 ST5 202440 s at 0.020547 1.65E-04 4.85 1.05 0.83009
441 GPR161 214104 at 0.020547 1.66E-04 4.85 1.05 0.73224
442 JAM2 229127 at 0.02083 1.68E-04 4.84 1.03 1.73631
443 N4BP2L2 202259 s at 0.020858 1.69E-04 -4.84 1.03 -0.91239
444 DKK3 214247 s at 0.020858 1.70E-04 4.84 1.03 1.84773
445 AXL 202686 s at 0.020858 1.70E-04 4.84 1.03 2.30553
446 CRTAP 1554464 a at 0.020918 1.71 E-04 4.84 1.02 1.97424
447 VTI1 B 225926 at 0.020961 1.71 E-04 4.84 1.02 1.32858
448 APLP2 208704 x at 0.020979 1.72E-04 4.83 1.01 1.07324
449 NID2 204114 at 0.021198 1.74E-04 4.83 1.00 1.98995
450 SCN1 B 205508 at 0.02124 1.75E-04 4.83 1.00 0.64826
451 BOD1 P 231368 at 0.02125 1.75E-04 -4.82 1.00 -0.39663
452 GAS5 228238 at 0.02125 1.76E-04 -4.82 0.99 -1.24063
453 SLC36A2/// 0.021325 -4.82 0.99
RPL24 214143 x at 1.77E-04 -0.45939
454 NFE2L1 200759 x at 0.021325 1.77E-04 4.82 0.99 0.57523
455 SMPD1 216230 x at 0.021325 1.77E-04 4.82 0.98 0.41890
456 RNASE1 201785 at 0.021325 1.79E-04 4.81 0.98 2.43798
457 VRK1 203856 at 0.021325 1.79E-04 -4.81 0.97 -0.84833
458 MAFB 222670 s at 0.021325 1.79E-04 4.81 0.97 1.43756
459 VCL 200931 s at 0.021325 1.80E-04 4.81 0.97 1.46099
460 SAV1 222573 s at 0.021325 1.80E-04 4.81 0.97 0.64872
461 ROB04 226028 at 0.021325 1.80E-04 4.81 0.97 1.08918
462 222877 at 0.021325 1.81 E-04 4.81 0.97 1.53354
463 RNF24 210706 s at 0.021325 1.81 E-04 4.81 0.97 0.71463
464 PRRG1 205618 at 0.021325 1.81 E-04 4.81 0.97 0.75809
465 PTGS1 205128 x at 0.021353 1.82E-04 4.81 0.96 1.51954
466 CD276 224859 at 0.021451 1.83E-04 4.80 0.96 0.68318
467 ZNF101 1552633 at 0.021671 1.85E-04 -4.80 0.94 -0.89394
No. Gene* Probe ID** Adj. p value P value t B Log FC
468 MIDI 203636 at 0.021671 1.86E-04 4.80 0.94 0.86926
469 GNA11 40562 at 0.021671 1.86E-04 4.80 0.94 1.05143
470 CX3CL1 823 at 0.021904 1.89E-04 4.79 0.93 0.94660
471 ATF6 203952 at 0.021904 1.89E-04 4.79 0.93 0.85056
472 ARHGAP1 202117 at 0.021932 1.89E-04 4.79 0.92 0.91932
473 ZSCAN16 219676 at 0.021948 1.90E-04 -4.79 0.92 -0.79858
474 MFAP3 213123 at 0.021948 1.90E-04 4.79 0.92 0.47144
475 PINK1 209018 s at 0.022018 1.91 E-04 4.78 0.91 0.60563
476 ASPH 205808 at 0.022103 1.92E-04 4.78 0.91 0.95628
477 NXN 219489 s at 0.022154 1.93E-04 4.78 0.90 1.27423
478 SPON2 218638 s at 0.022543 1.97E-04 4.77 0.88 1.65146
479 ADAM9 202381 at 0.022543 1.97 E-04 4.77 0.88 1.84934
480 LEPR 211356 x at 0.022747 2.00E-04 4.76 0.87 1.02768
481 PROS1 207808 s at 0.022818 2.01 E-04 4.76 0.87 1.39262
482 PRRX1 226695 at 0.022818 2.01 E-04 4.76 0.87 1.54398
483 LOC100132 0.022871 -4.76 0.86
999 229872 s at 2.02E-04 -0.84908
484 ENC1 201341__at 0.022942 2.03E-04 4.75 0.86 1.26031
485 233909 at 0.022978 2.04E-04 -4.75 0.85 -0.43067
486 CPXM2 226824 .at 0.022978 2.04E-04 4.75 0.85 1.15564
487 ACOX1 227962 at 0.023298 2.08E-04 4.74 0.84 1.08664
488 ZNF107 205739 x at 0.02338 2.09E-04 -4.74 0.83 -1.29788
489 PAPSS2 203060 s at 0.023419 2.10E-04 4.74 0.83 1.29832
490 PPAP2B 212226 s at 0.023419 2.10E-04 4.74 0.83 1.88639
491 LA C1 200771 at 0.023419 2.10E-04 4.74 0.82 1.73674
492 SLC38A7 218727 at 0.023419 2.11 E-04 4.74 0.82 0.97506
493 SYNC 221276 s at 0.023433 2.12E-04 4.73 0.82 0.77826
494 MAP 7 35617 at 0.023433 2.12E-04 4.73 0.82 0.64280
495 XRA8 213422_s_at 0.023498 2.13E-04 4.73 0.81 1.47570
496 LAMA4 210990 s at 0.02351 2.13E-04 4.73 0.81 0.55581
497 KIAA0090 212396 s at 0.02351 2.14E-04 4.73 0.81 0.89329
498 RAB31 217764 s at 0.023612 2.15E-04 4.73 0.80 1.24839
499 NDRG3 224368 s at 0.023746 2.17E-04 4.72 0.80 0.79271
500 SULF2 233555 s at 0.023836 2.18E-04 4.72 0.79 1.93828
501 MRP63 204387 x at 0.023836 2.18E-04 -4.72 0.79 -0.80978
502 CENPBD1 1552330 at 0.023895 2.19E-04 4.72 0.79 0.72161
503 EMP2 204975 at 0.023913 2.20E-04 4.71 0.78 1.50356
504 MAOA 212741 at 0.023913 2.20E-04 4.71 0.78 2.09607
505 MAOB 204041 at 0.023919 2.21 E-04 4.71 0.78 1.23400
506 229830 at 0.023919 2.21 E-04 4.71 0.78 1.05607
507 AEBP1 201792 at 0.024121 2.24E-04 4.71 0.77 1.68374
508 FCGR2C 210992 x at 0.024121 2.24E-04 4.71 0.77 1.77068
509 F2D1 204451 at 0.024189 2.25E-04 4.70 0.76 1.48559
510 ENG 201809 s at 0.024189 2.26E-04 4.70 0.76 1.551 15
511 PLAUR 211924 s at 0.024189 2.26E-04 4.70 0.76 1.42853
512 PRKAR1A 200604 s at 0.024291 2.28E-04 4.70 0.75 1.66140
513 ABL1 202123 s at 0.024291 2.28E-04 4.70 0.75 1.26442
514 BACE1 217904 s at 0.024292 2.28E-04 4.70 0.75 0.89522
515 226865 at 0.024308 2.29E-04 4.70 0.74 1.97728
516 FARP1 20191 1 s at 0.024308 2.30E-04 4.69 0.74 1.11 185
517 KIAA1462 231841 s at 0.024308 2.30E-04 4.69 0.74 1.07959
518 CAV2 203324 s at 0.02434 2.31 E-04 4.69 0.74 1.21581
519 SSPN 204964 s at 0.024344 2.31 E-04 4.69 0.74 0.95659
520 TRIM47 225868 at 0.024539 2.34E-04 4.69 0.73 0.99714
521 FU46875 230203 at 0.024539 2.34E-04 -4.69 0.73 -0.46853
522 CITED2 207980 s at 0.024734 2.36E-04 4.68 0.72 1.81310
523 2NF703 222760 at 0.024781 2.38E-04 4.68 0.71 0.77048
524 TGFBR3 204731 at 0.024781 2.38E-04 4.68 0.71 1.67984
525 HIST2H4B/// 0.024781 -4.68 0.71
HIST4H4///H
IST2H4A //H
IST1 H4L///H
IST1 H4E///H
IST1 H4B///H
IST1 H4H///H
IST1 H4C///H
IST1 H4J///HI
ST1 H4K //HI
ST1 H4F///HI
ST1 H4D///HI 205967 at 2.38E-04 -1.43194
No. Gene* Probe ID** Adj. p value P value t B Log FC
ST1H4A///HI
ST1H4I
526 GUCY1A3 221942 s at 0.024781 2.38E-04 4.68 0.71 1.77865
527 ANPEP 202888 s at 0.024835 2.39E-04 4.67 0.70 2.24123
528 MXD1 228846 at 0.024907 2.41 E-04 4.67 0.70 0.94890
529 TPP1 200743 s at 0.024907 2.41 E-04 4.67 0.70 1.52229
530 SLC39A6 1556551 s at 0.024926 2.42E-04 4.67 0.70 1.12307
531 RGS10 204316 at 0.024944 2.43E-04 -4.67 0.69 -0.73706
532 BOK 223349 s at 0.024944 2.43E-04 4.67 0.69 0.99462
533 SEC61A1 222385 x at 0.025088 2.45E-04 4.66 0.68 1.50497
534 CCL11 210133 at 0.025088 2.45E-04 4.66 0.68 3.90678
535 SCARB2 201647 s at 0.025088 2.46E-04 4.66 0.68 1.73118
536 238835 at 0.025088 2.46E-04 4.66 0.68 0.94722
537 NFIB 209290 s at 0.0251 2.47E-04 4.66 0.68 1.41474
538 MFGE8 210605 s at 0.025126 2.49E-04 4.66 0.67 1.02129
539 RHOJ 235131 at 0.025126 2.49E-04 4.66 0.67 0.50927
540 SQSTM1 239004 at 0.025126 2.49E-04 -4.66 0.67 -0.57404
541 CRYAB 209283 at 0.025126 2.49E-04 4.66 0.67 1.24518
542 CTNND1 208407 s at 0.025126 2.49E-04 4.65 0.67 1.68808
543 ZAK 225665 at 0.025126 2.50E-04 4.65 0.66 1.00803
544 231047 at 0.025126 2.50E-04 -4.65 0.66 -0.38958
545 PHC2 200919 at 0.025126 2.50E-04 4.65 0.66 0.73639
546 NFIB 230291 s at 0.025226 2.52E-04 4.65 0.65 1.12985
547 ZNF436 226113 at 0.025226 2.52E-04 4.65 0.65 0.59624
548 NRP2 229225 at 0.025386 2.55E-04 4.64 0.65 0.75874
549 C10orf72 235471 at 0.025386 2.55E-04 4.64 0.65 0.43936
550 CD99L2 223041 at 0.025421 2.56E-04 4.64 0.64 1.00933
551 GNAI1 209576 at 0.025542 2.57E-04 4.64 0.64 0.71797
552 MOSC2 227417 at 0.025665 2.59E-04 4.64 0.63 1.20595
553 C14orf181 229054 at 0.02568 2.60E-04 -4.63 0.63 -0.54209
554 ITGA5 201389 at 0.02568 2.60E-04 4.63 0.63 1.22182
555 MMP2 201069 at 0.025713 2.61 E-04 4.63 0.62 2.86428
556 PYGL 202990_at 0.025811 2.62E-04 4.63 0.62 1.66558
557 244429 at 0.026005 2.65E-04 -4.63 0.61 -1.21144
558 COL4A4 229779 at 0.026145 2.67E-04 4.62 0.60 1.39339
559 CDHR3 235650 at 0.026154 2.67E-04 -4.62 0.60 -0.34034
560 RIN2 209684 at 0.026255 2.69E-04 4.62 0.59 1.88835
561 CL1C4 221881 s at 0.026303 2.70E-04 4.62 0.59 1.07758
562 DAB2 210757_x_at 0.026417 2.72E-04 4.61 0.59 1.85966
563 FCGR2C 211395 x at 0.026698 2.75E-04 4.61 0.57 2.24120
564 SY J1 207594 s at 0.026728 2.76E-04 4.61 0.57 0.38123
565 UBE4B 202316 x at 0.026728 2.76E-04 4.61 0.57 0.65987
566 DOCK5 230263 s at 0.026736 2.77E-04 4.60 0.57 1.00949
567 ODF3B 238326 at 0.026821 2.78E-04 -4.60 0.56 -0.88795
568 OLFML2B 213125 at 0.026821 2.79E-04 4.60 0.56 1.91869
569 HSPA5 230031 at 0.026973 2.81 E-04 4.60 0.55 1.02556
570 TBC1 D10B 220947 s at 0.027009 2.82E-04 4.60 0.55 0.65889
571 ZNF143 221873 at 0.027059 2.83E-04 -4.59 0.55 -0.55616
572 C5AR1 220088 at 0.027059 2.83E-04 4.59 0.55 1.16628
573 RBPMS 209487 at 0.027059 2.84E-04 4.59 0.55 1.41852
574 TMEM185B 219253 at 0.027176 2.85E-04 4.59 0.54 0.93704
575 T E 54 225536 at 0.027213 2.86E-04 4.59 0.54 0.73553
576 FARP1 201910 at 0.027327 2.88E-04 4.59 0.53 0.87308
577 PARVB 37965 at 0.027377 2.89E-04 4.58 0.53 1.15378
578 SLC29A1 201801 s at 0.027377 2.89E-04 4.58 0.53 0.70968
579 LOC100216 0.027501 -4.58 0.52
545 238473 at 2.91 E-04 -0.46750
580 C20orf194 226607 at 0.027646 2.93E-04 4.58 0.51 1.00425
581 LAMB1 211651 s at 0.027774 2.95E-04 4.57 0.51 1.86791
582 MRVI1 226047 at 0.027774 2.96E-04 4.57 0.51 1.25387
583 SUOX 204067 at 0.027774 2.96E-04 4.57 0.50 0.92970
584 227333 at 0.027797 2.97E-04 4.57 0.50 0.77295
585 SYNJ2 216180 s at 0.027947 2.99E-04 -4.57 0.50 -0.65653
586 IER5L 226552 at 0.028007 3.01 E-04 4.57 0.49 0.75112
587 SLC2A3 202498 s at 0.028007 3.01 E-04 4.56 0.49 0.95646
588 TTC28 213058 at 0.028007 3.02E-04 4.56 0.49 0.97120
589 PRNP 215707 s at 0.028007 3.02E-04 4.56 0.49 1.13618
590 EMP1 201325 s at 0.028007 3.02E-04 4.56 0.49 1.45110
591 G6PC3 44654 at 0.02802 3.04E-04 4.56 0.48 0.65562
No. Gene* Probe ID** Adj. p value P value ί B Log FC
592 DAB2 201279 s at 0.02802 3.04E-04 4.56 0.48 1.89444
593 FCGR2B 210889 s at 0.02802 3.04E-04 4.56 0.48 1.89654
594 243005 at 0.02811 3.05E-04 -4.56 0.48 -0.41515
595 PDIA5 203857 s at 0.02833 3.09E-04 4.55 0.47 1.52185
596 PILRA 219788 at 0.02833 3.09E-04 4.55 0.46 1.33867
597 ELL3 219517 at 0.02833 3.09E-04 -4.55 0.46 -1.54247
598 OSBPL1A 209485 s at 0.028408 3.11 E-04 4.55 0.46 1.21034
599 CYB5R3 201885 s at 0.028408 3.11 E-04 4.55 0.46 0.96084
600 EPB41 L3 212681 at 0.028408 3.12E-04 4.55 0.46 1.49867
601 SIAE 224391 s at 0.028417 3.13E-04 4.55 0.45 1.22255
602 PLS3 201215 at 0.028417 3.13E-04 4.55 0.45 1.31701
603 WLS 228949 at 0.028438 3.14E-04 4.54 0.45 1.21715
604 SCD5 224901 at 0.028725 3.17E-04 4.54 0.44 1.06748
605 OS9 200714 x at 0.028782 3.18E-04 4.54 0.44 0.68887
606 243353 at 0.02884 3.20E-04 -4.54 0.43 -0.36946
607 TPSB2///TP 0.028939 4.53 0.43
SAB1 205683 x at 3.21 E-04 1.85701
608 FAM13A 202973 x at 0.029343 3.28E-04 4.52 0.41 1.45105
609 DKK3 202196 s at 0.029343 3.28E-04 4.52 0.41 0.91861
610 NFE2L1 200758 s at 0.029343 3.28E-04 4.52 0.41 0.81408
611 PTGFRN 224950 at 0.029343 3.29E-04 4.52 0.41 0.99305
612 GLIS3 230258 at 0.029343 3.29E-04 4.52 0.41 0.80398
613 TBC1 D8 241017 at 0.029343 3.29E-04 -4.52 0.41 -1.05016
614 GGCX 205351 at 0.029698 3.34E-04 4.51 0.39 1.12065
615 TMEM8A 221882 s at 0.029698 3.35E-04 4.51 0.39 1.04350
616 CLEC11A 210783 x at 0.029698 3.35E-04 4.51 0.39 0.54387
617 LOC730631 230738 at 0.029698 3.35E-04 -4.51 0.39 -0.47872
618 ZBED1 203043 at 0.029744 3.36E-04 4.51 0.39 0.76900
619 NUP43 219007 at 0.029797 3.38E-04 -4.51 0.38 -0.53934
620 DNAJC5 224612 s at 0.029797 3.39E-04 4.51 0.38 1.00074
621 CNKSR3 227481 at 0.029797 3.39E-04 4.51 0.38 1.09835
622 AQP1 207542 s at 0.029797 3.39E-04 4.51 0.38 1.26686
623 TEAD4 41037_at 0.029797 3.40E-04 4.51 0.38 0.71775
624 EFEMP2 206580_s_at 0.029816 3.40E-04 4.51 0.37 1.36034
625 CMKLR1 229121 at 0.029899 3.42E-04 4.50 0.37 1.36151
626 MYEF2 222771 s at 0.029899 3.42E-04 -4.50 0.37 -0.73296
627 B4GALT1 201883 s at 0.030015 3.44E-04 4.50 0.36 1.11907
628 BCL2L2 209311 at 0.030019 3.45E-04 4.50 0.36 1.05027
629 TIGD1 1553099 at 0.030091 3.47E-04 -4.50 0.36 -0.96165
630 DLG5 201681 s at 0.030091 3.47E-04 4.50 0.36 1.20045
631 GAB1 225998 at 0.03028 3.51 E-04 4.49 0.35 0.81171
632 GPR116 212950 at 0.03028 3.51 E-04 4.49 0.35 1.96512
633 CD151 204306 s at 0.03028 3.51 E-04 4.49 0.34 0.94867
634 238852 at 0.03028 3.51 E-04 4.49 0.34 1.19243
635 RANBP9 216125 s at 0.03028 3.52E-04 4.49 0.34 0.71779
636 RPL37 224766 at 0.030546 3.55E-04 -4.49 0.33 -0.43479
637 TPSAB1 207741 x at 0.030575 3.56E-04 4.48 0.33 1.42670
638 CDC42EP5 227850 x at 0.030596 3.57E-04 4.48 0.33 1.13370
639 PES1 202212 at 0.030686 3.59E-04 4.48 0.33 0.51626
640 CARD10 210026 s at 0.030701 3.59E-04 4.48 0.32 0.83368
641 KIAA1211 227230 s at 0.030714 3.60E-04 4.48 0.32 0.86840
642 CALD1 201617 x at 0.030714 3.61 E-04 4.48 0.32 1.66133
643 SMTN 209427 at 0.030864 3.63E-04 4.48 0.31 0.76710
644 FNIP2 226460 at 0.030974 3.65E-04 4.47 0.31 1.57408
645 FAM127A 201828 x at 0.031103 3.67E-04 4.47 0.30 1.42080
646 RCAN1 208370 s at 0.031103 3.68E-04 4.47 0.30 1.40322
647 CCL23 210549 s at 0.031103 3.68E-04 4.47 0.30 2.94623
648 C22orf32 225794 s at 0.031103 3.69E-04 -4.47 0.30 -0.91630
649 CCDC80 225241 at 0.031106 3.71 E-04 4.46 0.29 1.95729
650 PTPRE 221840 at 0.031106 3.71 E-04 4.46 0.29 1.30404
651 KLF7 204334 at 0.031106 3.72E-04 4.46 0.29 1.14131
652 MGC16121 237986 at 0.031106 3.72E-04 -4.46 0.29 -0.52477
653 C21orf58 238541 at 0.031106 3.72E-04 -4.46 0.29 -0.52000
654 PMP22 210139 s at 0.031106 3.72E-04 4.46 0.29 1.84511
655 SPATS2L 215617 at 0.031106 3.73E-04 4.46 0.29 0.61954
656 RERG 244745 at 0.031123 3.73E-04 4.46 0.29 0.76484
657 RPSAP19/// 0.031126 -4.46 0.29
RPSAP9///R
PSAP58///R 213801 x at 3.74E-04 -0.49779
No. Gene* Probe ID** Adj. p value P value t e Log FC
PSA
658 C20orf196 235064 s at 0.031126 3.75E-04 -4.46 0.28 -0.55922
659 ERC1 226049 at 0.031149 3.76E-04 4.46 0.28 0.64279
660 ACVRL1 210838 s at 0.031149 3.76E-04 4.46 0.28 0.89811
661 TNS1 221748 s at 0.031288 3.78E-04 4.46 0.28 1.85327
662 TMEM127 222887 s at 0.031288 3.79E-04 4.45 0.27 0.90948
663 239234 at 0.031528 3.82E-04 -4.45 0.27 -0.84663
664 TSPAN4 209264 s at 0.031595 3.84E-04 4.45 0.26 1.81703
665 FAM171A1 212771 at 0.031692 3.86E-04 4.45 0.26 1.20964
666 DPYSL3 201431 s at 0.031692 3.86E-04 4.45 0.26 1.46803
667 ITGB5 201125 s at 0.031692 3.87E-04 4.44 0.25 1.43039
668 TNFRSF1A 207643 s at 0.031692 3.87E-04 4.44 0.25 1.29273
669 CKAP4 200999 s at 0.031925 3.91 E-04 4.44 0.25 1.66982
670 C1 orf85 1558693 s at 0.031996 3.92E-04 4.44 0.24 1.27039
671 RBMS1 203748 x at 0.032116 3.95E-04 4.44 0.24 1.68308
672 PTP4A1 200731 s at 0.032116 3.95E-04 4.44 0.24 0.64143
673 PLA2G4B/// 0.032116 -4.43 0.23
JMJD7///JM
JD7-
P1.A2G4B 219095 at 3.95E-04 -0.48547
674 RGS5 209071 s at 0.032171 3.97E-04 4.43 0.23 1.46125
675 ZCRB1 225394 s at 0.032195 3.98E-04 -4.43 0.23 -0.86706
676 ATP2A2 212361 s at 0.032195 3.98E-04 4.43 0.23 1.67396
677 GPR172A 222155 s at 0.032225 3.99E-04 4.43 0.22 1.17604
678 NUCB1 200646 s at 0.032225 4.00 E-04 4.43 0.22 0.93478
679 TPP1 200742 s at 0.032259 4.01 E-04 4.43 0.22 2.25644
680 EXD2 218363 at 0.032298 4.02E-04 4.43 0.22 0.52725
681 P4HB 1564494 s at 0.032363 4.03E-04 4.43 0.22 2.25675
682 CRTAP 226656_at 0.032363 4.04E-04 4.42 0.21 0.56404
683 PTAFR 211661_x_at 0.032414 4.05E-04 4.42 0.21 1.72809
684 DAB2 201280 s at 0.032439 4.06E-04 4.42 0.21 1.78055
685 PLE HG5 237646 x at 0.032489 4.07E-04 -4.42 0.21 -0.39150
686 RHOBTB3 225202 at 0.032561 4.09E-04 4.42 0.20 1.72218
687 FAM114A1 213455 at 0.032752 4.12E-04 4.42 0.20 1.62996
688 HK1 200697 at 0.033058 4.16E-04 4.41 0.19 0.86927
689 SLC39A6 1555460 a at 0.033065 4.17E-04 4.41 0.18 0.73954
690 SLC35E1 227518 at 0.03312 4.18 E-04 4.41 0.18 0.78059
691 LMLN 244881_at 0.033248 4.20E-04 4.41 0.18 0.82582
692 ZNF92 235170 at 0.033248 4.21 E-04 -4.40 0.18 -0.75031
693 PPAP2B 212230 at 0.033282 4.22E-04 4.40 0.17 1.90846
694 239587 at 0.033282 4.22E-04 4.40 0.17 0.52368
695 RANBP9 202583 s at 0.033356 4.24E-04 4.40 0.17 1.23793
696 MBD4 214047 s at 0.033456 4.26E-04 -4.40 0.16 -0.54211
697 RNASEH2B 229210 at 0.033456 4.27E-04 -4.40 0.16 -0.61713
698 RHOQ 214449 s at 0.033456 4.28E-04 4.40 0.16 1.23017
699 HOMER3 215489 x at 0.033456 4.28E-04 4.40 0.16 0.63242
700 LTBR 203005 at 0.033456 4.28E-04 4.40 0.16 1.09369
701 MGAT4B 220189 s at 0.033456 4.29E-04 4.40 0.16 1.26687
702 SRPX 204955 at 0.033456 4.30E-04 4.39 0.16 2.33227
703 NUDT4P1/// 0.033456 4.39 0.15
NUDT4 212183 at 4.32E-04 0.91986
704 COL27A1 225288 at 0.033456 4.33E-04 4.39 0.15 0.70812
705 LGALS3BP 200923 at 0.033456 4.33E-04 4.39 0.15 2.16150
706 C5orf45 220341 s at 0.033456 4.33E-04 -4.39 0.15 -0.37485
707 TBX3 219682 s at 0.033456 4.33E-04 4.39 0.15 0.46948
708 CPD 201940 at 0.033456 4.33E-04 4.39 0.15 1.1 480
709 FRMD4A 225167 at 0.033457 4.34E-04 4.39 0.15 0.93206
710 C14orf135 235188 at 0.033457 4.34E-04 -4.39 0.15 -0.26938
711 MYL 224823 at 0.033466 4.35E-04 4.39 0.14 1.33041
712 ZNF430 238614 x at 0.033517 4.37E-04 -4.39 0.14 -0.55266
713 1556173 a at 0.033517 4.37E-04 -4.39 0.14 -0.80860
714 Q I 214543 x at 0.033517 4.38E-04 4.39 0.14 0.65036
715 TIMM16 218969 at 0.033556 4.39E-04 -4.38 0.14 -0.69464
716 MD 209035 at 0.03359 4.40E-04 4.38 0.13 0.57952
717 ATP8A1 213106 at 0.033616 4.41 E-04 -4.38 0.13 -0.99107
718 C2orf55 228067 at 0.033616 4.41 E-04 4.38 0.13 0.77948
719 TP53I3 210609 s at 0.03369 4.43E-04 4.38 0.13 1.09651
720 TIA1 201446 s at 0.03369 4.44E-04 -4.38 0.13 -0.95595
721 214083 at 0.033992 4.48E-04 -4.37 0.12 -0.88587
Wo. Gene* Probe ID"* Adj. p value P value t B Log FC
722 MYAD 224920 x at 0.034093 4.50E-04 4.37 0.11 0.99766
723 ZNF346 236267 at 0.034093 4.51 E-04 -4.37 0.11 -0.81229
724 GTPBP8 221046 s at 0.034155 4.52E-04 -4.37 0.11 -0.83113
725 1FIT 3 212203 x at 0.034171 4.54E-04 4.37 0.10 1.53477
726 KIRREL 225303 at 0.034171 4.54E-04 4.37 0.10 1.37093
727 WTR1 202134 s at 0.034171 4.55E-04 4.37 0.10 0.38767
728 CDV3 213548 s at 0.034171 4.55E-04 4.37 0.10 1.12634
729 PTRF 1557938 s at 0.034171 4.56E-04 4.37 0.10 0.73207
730 FLJ 10357 220326 s at 0.034263 4.58E-04 4.36 0.10 0.53826
731 HEPH 203903 s at 0.034263 4.59E-04 4.36 0.09 1.41699
732 ARCKS 225897 at 0.034263 4.61 E-04 4.36 0.09 1.68777
733 GALNT10 207357 s at 0.034263 4.62E-04 4.36 0.09 0.81551
734 SCUBE2 219197 s at 0.034263 4.62E-04 4.36 0.09 0.65198
735 LRP10 201412 at 0.034263 4.62E-04 4.36 0.09 0.93689
736 1NTS10 229632 s at 0.034263 4.63E-04 -4.36 0.09 -0.59292
737 DAG1 205417_s_at 0.034263 4.64E-04 4.36 0.08 0.92720
738 FA 108C1 225436 at 0.034263 4.64E-04 4.36 0.08 0.71845
739 PDLI 5 216804 s at 0.034263 4.64E-04 4.36 0.08 0.97517
740 NFE2L2 1567014 s at 0.034263 4.64E-04 4.36 0.08 0.60581
741 SERP1NE1 202628 s at 0.034263 4.64E-04 4.36 0.08 1.80135
742 C1 orf163 222883 at 0.034263 4.65E-04 4.36 0.08 0.46664
743 1560327 at 0.034263 4.66E-04 4.36 0.08 0.75420
744 APH1A 1554417 s at 0.034432 4.69E-04 4.35 0.07 1.02550
745 GPAA1 201618 x at 0.034551 4.72E-04 4.35 0.07 0.54600
746 ALDH6A1 221588 x at 0.034551 4.72E-04 4.35 0.07 1.00962
747 E P2 225079 at 0.034551 4.72E-04 4.35 0.07 0.85898
748 TRIOBP 210276 s at 0.034596 4.73E-04 4.35 0.07 1.40267
749 CSF1 R 203104 at 0.034844 4.77E-04 4.34 0.06 1.92797
750 P2RX5 210448 s at 0.035062 4.81 E-04 -4.34 0.05 -1.12419
751 234997 x at 0.035567 4.89E-04 -4.33 0.04 -1.12968
752 NLRX1 219680 at 0.035599 4.90E-04 4.33 0.03 0.58163
753 C1orf198 223063 at 0.035604 4.91 E-04 4.33 0.03 0.99413
754 KDELR2 200699 at 0.035604 4.93E-04 4.33 0.03 1.65069
755 ZCCHC7 226496 at 0.035604 4.93E-04 -4.33 0.03 -0.91638
756 NRGN 204081 at 0.035604 4.93E-04 4.33 0.03 0.50535
757 VPS35 217727 x at 0.035604 4.95E-04 4.33 0.02 0.62292
758 RAPGEF1 226389 s at 0.035604 4.95E-04 4.33 0.02 0.66261
759 NP 1 200063 s at 0.035604 4.95E-04 -4.33 0.02 -0.36318
760 TIA1 1554890 a at 0.035604 4.96E-04 -4.33 0.02 -0.69958
761 D 4 225740 x at 0.035604 4.96E-04 -4.33 0.02 -1.01911
762 KDELR3 207265 s at 0.035604 4.96E-04 4.33 0.02 1.23097
763 C20orf108 224693 at 0.035623 4.98E-04 4.33 0.02 0.68176
764 SRB3 225782 at 0.035623 4.98E-04 4.32 0.02 1.85042
765 T CC1 227112 at 0.035666 4.99E-04 4.32 0.02 0.73259
766 RNF138 239143 x at 0.035715 5.00E-04 -4.32 0.01 -0.58447
767 239081 at 0.035754 5.02E-04 -4.32 0.01 -0.84667
768 CARD8 228641 at 0.035754 5.02E-04 -4.32 0.01 -0.84801
769 IQCK 213392 at 0.035755 5.03E-04 4.32 0.01 0.79628
770 CEBPD 203973 s at 0.035828 5.05E-04 4.32 0.01 1.30337
771 HOXA5 213844 at 0.035901 5.06E-04 4.32 0.00 1.03425
772 LOC100131 0.035901 -4.32 0.00
801 226006 at 5.07E-04 -0.76506
773 ARRB1 218832 x at 0.036014 5.10E-04 4.31 0.00 0.87070
774 PPIC 204518 s at 0.036014 5.10E-04 4.31 0.00 1.50886
775 Y01 B 212365 at 0.036033 5.11 E-04 4.31 -0.01 0.91174
776 HINT3 228697 at 0.036097 5.12E-04 4.31 -0.01 1.00509
777 PTP4A1 200732 s at 0.036275 5.16E-04 4.31 -0.01 1.05606
778 HSD17B7 220081 x at 0.036278 5.16E-04 -4.31 -0.02 -0.90546
779 CTNND1 211240 x at 0.036335 5.19E-04 4.31 -0.02 0.74397
780 BCKDK 202030 at 0.036335 5.19E-04 4.31 -0.02 1.15357
781 LRRC41 1555831 s at 0.036335 5.19E-04 4.31 -0.02 1.18466
782 WISP1 206796 at 0.03661 5.24E-04 4.30 -0.03 1.40144
783 YIF1 B 226437 at 0.03661 5.25E-04 4.30 -0.03 1.09293
784 PPARA 223438 s at 0.03661 5.25E-04 4.30 -0.03 0.93721
785 GADD45B 209304 x at 0.03673 5.27E-04 4.30 -0.04 0.76313
786 NCRNA000 0.037188 4.29 -0.05
94 213788 s at 5.35E-04 0.58544
787 CTSF 203657 s at 0.037281 5.37E-04 4.29 -0.05 0.57562
788 214124 x at 0.037281 5.38E-04 -4.29 -0.05 -0.61868
No. Gene* Probe ID** Adj. p value P value t S Log PC
789 LOC 100129 0.037281 -4.29 -0.05
122 239356 at 5.38E-04 -0.40842
790 SIL1 218436 at 0.037447 5.41 E-04 4.29 -0.06 0.67200
791 THBD 237252 at 0.037447 5.42E-04 4.28 -0.06 0.73532
792 ZNF254 242602 x at 0.037514 5.43E-04 -4.28 -0.06 -0.63648
793 COL8A2 52651 at 0.037839 5.49E-04 4.28 -0.07 0.40550
794 FAM171 B 227370 at 0.037877 5.50E-04 4.28 -0.08 0.95920
795 CLEC4G 1559065 a at 0.037884 5.51 E-04 4.28 -0.08 1.88315
796 TEAD2 226408 at 0.037884 5.52E-04 4.28 -0.08 0.79559
797 S4A1 231418_at 0.038026 5.54E-04 -4.27 -0.08 -1.67144
798 SLC02A1 204368_at 0.038033 5.57E-04 4.27 -0.09 1.61484
799 217449 at 0.038033 5.57E-04 -4.27 -0.09 -0.32686
800 AQP1 209047 at 0.038033 5.58E-04 4.27 -0.09 2.08361
801 RTKN 225150 s at 0.038033 5.58E-04 4.27 -0.09 0.37584
802 LDOC1 L 223228 at 0.038033 5.60E-04 4.27 -0.09 1.07653
803 FBLI 1 225258_at 0.038033 5.60E-04 4.27 -0.09 1.10747
804 FKBP3 218003 s at 0.038033 5.60E-04 -4.27 -0.09 -0.53713
805 AGTRAP 1555736 a at 0.038033 5.60E-04 4.27 -0.09 1.40821
806 C19orf43 230213 at 0.038156 5.63E-04 -4.27 -0.10 -0.55467
807 SLC35C1 222647 at 0.038156 5.63E-04 4.27 -0.10 0.42724
808 ZFAND3 222493_s at 0.038164 5.64E-04 4.27 -0.10 0.60623
809 RBP S 207836 s at 0.038222 5.66E-04 4.26 -0.10 0.98825
810 TBC1 D12 221858 at 0.038222 5.66E-04 4.26 -0.10 0.65871
811 CADPS2 219572 at 0.038277 5.68E-04 4.26 -0.11 0.86561
812 TTLL12 1552257 a at 0.038568 5.73E-04 4.26 -0.11 0.66614
813 KCNE4 1552508 at 0.038599 5.74E-04 4.26 -0.12 0.75158
814 STXBP1 202260 s at 0.038609 5.75E-04 4.26 -0.12 1.24889
815 TFPI 213258 at 0.038613 5.76E-04 4.26 -0.12 1.93688
816 ASPH 210896 s at 0.038617 5.76E-04 4.26 -0.12 1.25136
817 LOC400043 226582 at 0.038755 5.79E-04 4.25 -0.12 0.75115
818 SLC02B1 203473 at 0.038755 5.80E-04 4.25 -0.13 1.26366
819 FE 1 C 213341 at 0.038757 5.81 E-04 4.25 -0.13 0.92246
820 OCRL 203446 s at 0.03877 5.82E-04 4.25 -0.13 0.55120
821 CATSPER2 1561405 s at 0.03877 5.82E-04 -4.25 -0.13 -0.31201
822 DIRC2 226026 at 0.039021 5.88E-04 4.25 -0.14 1.10364
823 VTI1B 225928 at 0.039021 5.89E-04 4.25 -0.14 0.74047
824 TAF1 D 218750 at 0.039021 5.90E-04 -4.24 -0.14 -1.42163
825 NLRP3 207075 at 0.039021 5.90E-04 4.24 -0.14 0.74364
826 Sep-08 208999 at 0.039021 5.90E-04 4.24 -0.14 1.14351
827 1562412 at 0.039021 5.91 E-04 -4.24 -0.14 -0.50777
828 STEAP3 218424 s at 0.039021 5.91 E-04 4.24 -0.14 1.20765
829 TFPI 209676 at 0.039021 5.92E-04 4.24 -0.14 0.90221
830 OLF L2A 213075 at 0.039021 5.92E-04 4.24 -0.15 1.25239
831 ALOX15 207328 at 0.039137 5.95E-04 4.24 -0.15 1.77807
832 LOC100131 0.039154 4.24 -0.15
845///1GHV4
-31///IGHA1 234792 x at 5.96E-04 1.21481
833 SMC3 1556925 at 0.039159 5.97E-04 -4.24 -0.15 -0.30973
834 KCNK6 223658 at 0.039159 5.97E-04 4.24 -0.15 0.80695
835 FNDC3B 222692 s at 0.039159 5.98E-04 4.24 -0.15 1.1 1460
836 LAMB2 216264 s at 0.039257 6.01 E-04 4.24 -0.16 0.88694
837 PDLIM5 203243 s at 0.039257 6.01 E-04 4.24 -0.16 1.88572
838 T 9SF1 209149 s at 0.039257 6.02E-04 4.24 -0.16 1.16215
839 SNHG6 225547 at 0.039299 6.03E-04 -4.23 -0.16 -0.90430
840 LOC6446 7 221235 s at 0.039299 6.04E-04 4.23 -0.16 0.71088
841 225269 s at 0.039356 6.05E-04 4.23 -0.17 0.65760
842 LOC439949 232001 at 0.039361 6.06E-04 -4.23 -0.17 -1.06936
843 TMIGD2 244716 x at 0.039388 6.07E-04 -4.23 -0.17 -0.88167
844 LOC100302 0.03976 -4.22 -0.18
652///ASB3//
/GPR75 232515 at 6.15E-04 -0.53288
845 PSEN1 226577 at 0.03976 6.15E-04 4.22 -0.18 0.80312
846 PECA 1 208983 s at 0.03976 6.15E-04 4.22 -0.18 1.80033
847 UPK3B 206658 at 0.03976 6.17E-04 -4.22 -0.18 -0.43321
848 SDF4 224472 x at 0.03976 6. 7E-04 4.22 -0.18 0.97219
849 CPD 201943 s at 0.03976 6.18E-04 4.22 -0.18 1.15344
850 RAB34 1555630 a at 0.03976 6.18E-04 4.22 -0.19 1.77694
851 SESTD1 226763 at 0.039847 6 20E-04 4.22 -0.19 0.77094
852 ICMT 201611 s at 0.039847 6.21 E-04 4.22 -0.19 1.19786
No. Gene* Probe ID** Adj. p value P value t B Log FC
853 C11orf76 224139 at 0.039871 6.22E-04 -4.22 -0.19 -0.35876
854 CTNS 36566 at 0.039996 6.25E-04 4.22 -0.19 0.94098
855 RLTPR 227218 at 0.040078 6.27E-04 -4.22 -0.20 -0.44060
856 STX4 203530 s at 0.040118 6.28E-04 4.21 -0.20 1.02897
857 SIRT5 229112 at 0.040155 6.30E-04 -4.21 -0.20 -0.41051
858 SH2D1A 211210 x at 0.040155 6.30E-04 -4.21 -0.20 -1.41674
859 KCTD12 212188 at 0.040155 6.31 E-04 4.21 -0.21 0.95007
860 LMNA 212086 x at 0.040155 6.32E-04 4.21 -0.21 0.88085
861 CALU 200755 s at 0.040155 6.33E-04 4.21 -0.21 1.34391
862 RND2 213467 at 0.040155 6.34E-04 -4.21 -0.21 -0.41543
863 PIR 207469 s at 0.040155 6.34E-04 4.21 -0.21 0.88090
864 GAS6 1598 g at 0.040184 6.35E-04 4.21 -0.21 0.75605
865 ZNF423 214761 at 0.040315 6.38E-04 4.21 -0.22 1.55901
866 C1QTNF1 220975 s at 0.040315 6.39E-04 4.21 -0.22 0.88142
867 227727 at 0.040357 6.40E-04 4.21 -0.22 1.01498
868 ACAD9 224160 s at 0.040395 6.42E-04 4.20 -0.22 0.58080
869 244075 at 0.040395 6.42E-04 -4.20 -0.22 -1.01682
870 FOXC1 1553613 s at 0.040399 6.44E-04 4.20 -0.22 1.28587
871 SELP 206049_at 0.040399 6.44E-04 4.20 -0.22 1.40873
872 LSM4 212924 s at 0.040399 6.45 E-04 -4.20 -0.22 -0.48894
873 GPR124 65718_at 0.040399 6.45E-04 4.20 -0.23 0.83645
874 227184 at 0.040399 6.46E-04 4.20 -0.23 1.15782
875 GGCX 235413_at 0.040429 6.48E-04 4.20 -0.23 0.56185
876 TRI 2 202341_s_at 0.040429 6.48 E-04 4.20 -0.23 0.69978
877 PDIA3 227033 at 0.040429 6.48E-04 4.20 -0.23 0.84889
878 SAE1 241185 at 0.040434 6.49E-04 -4.20 -0.23 -0.45017
879 DCBLD2 224911 s at 0.040464 6.51 E-04 4.20 -0.23 1.32095
880 232710_at 0.040474 6.51 E-04 -4.20 -0.23 -0.69623
881 MS4A7 224358 s at 0.040647 6.56E-04 4.19 -0.24 2.45217
882 GPR176 227846 at 0.040647 6.56E-04 4.19 -0.24 0.58377
883 FLU 212025 s at 0.04067 6.57E-04 4.19 -0.24 1.13010
884 TBXAS1 208130 s at 0.040672 6.58E-04 4.19 -0.24 1.08248
885 RNASEH2B 215040 at 0.040672 6.59E-04 -4.19 -0.24 -0.67966
886 230449 x at 0.040672 6.61 E-04 -4.19 -0.25 -0.50978
887 LAPTM4B 214039 s at 0.040672 6.62E-04 4.19 -0.25 1.69716
888 P4HB 200654 at 0.040672 6.62E-04 4.19 -0.25 1.38657
889 CTNS 204925 at 0.040672 6.62 E-04 4.19 -0.25 1.43333
890 GZF1 225884 s at 0.040672 6.62E-04 4.19 -0.25 0.73137
891 SH3BP4 222258 s at 0.040901 6.67E-04 4.19 -0.26 1.19720
892 FAM127B 217948 at 0.040947 6.68E-04 4.19 -0.26 1.00404
893 L BR1 224410 s at 0.040947 6.70E-04 4.18 -0.26 0.82889
894 EFE P1 201842 s at 0.040947 6.70E-04 4.18 -0.26 2.32422
895 FGFR10P2 236808 at 0.040947 6.70E-04 -4.18 -0.26 -0.88608
896 HDLBP 221767 x at 0.040973 6.71 E-04 4.18 -0.26 1.07834
897 B3GALTL 227100 at 0.041043 6.74E-04 4.18 -0.27 0.54948
898 DMD 203881 s at 0.041043 6.74E-04 4.18 -0.27 0.98105
899 235821 at 0.041054 6.75E-04 4.18 -0.27 1.52425
900 230980 x at 0.041054 6.76E-04 -4.18 -0.27 -0.87726
901 NET01 1552736 a at 0.041054 6.77E-04 -4.18 -0.27 -0.40033
902 ATP6V1A 201971 s at 0.041169 6.79E-04 4.18 -0.27 1.22810
903 ADRB 2 204184 s at 0.041425 6.84E-04 4.17 -0.28 0.43207
904 FNBP1 L 215017 s at 0.041483 6.86E-04 4.17 -0.28 0.83766
905 AKAP12 210517 s at 0.041562 6.90E-04 4.17 -0.29 1.86963
906 SEL1L 230265 at 0.041562 6.90E-04 4.17 -0.29 1.01191
907 LEPROT 202378 s at 0.041562 6.90E-04 4.17 -0.29 1.18731
908 FNDC3A 215910 s at 0.041562 6.91 E-04 4.17 -0.29 0.36692
909 AXIN2 222695 s at 0.041562 6.92E-04 -4.17 -0.29 -0.54695
910 FGFR1 207822 at 0.041562 6.92E-04 -4.17 -0.29 -0.40135
911 PAFAH1 B1 200813 s at 0.041575 6.93E-04 4.17 -0.29 0.77379
912 TBC1D9B 212054 x at 0.041575 6.93E-04 4.17 -0.29 0.65719
913 PON2 210830 s at 0.041596 6.95E-04 4.17 -0.30 1.41795
914 GUCY1A3 229530 at 0.041596 6.95 E-04 4.17 -0.30 1.56360
915 230599 at 0.041614 6.97E-04 -4.17 -0.30 -1.34701
916 ZNF443 205928 at 0.041614 6.97E-04 -4.17 -0.30 -0.67379
917 PTGER1 214391 x at 0.041621 6.99E-04 -4.16 -0.30 -0.56740
918 PTEN 225363 at 0.041621 7.00E-04 4.16 -0.30 0.47087
919 NAGA 202943 s at 0.041621 7.00E-04 4.16 -0.30 1.49995
920 GPR56 212070 at 0.041621 7.01 E-04 4.16 -0.30 0.74150
921 MALL 209373 at 0.041621 7.02E-04 4.16 -0.30 1.10485
123
No. Gene* Probe /D** Adj. p value P value f B Log FC
922 IL13RA1 210904 s at 0.041621 7.02E-04 4.16 -0.30 1.70643
923 239131 at 0.041702 7.05E-04 -4.16 -0.31 -0.58305
924 SPTLC1 202278 s at 0.041702 7.05E-04 4.16 -0.31 0.68724
925 GTF2H2D/// 0.041702 -4.16 -0.31
GTF2H2C///
GTF2H2B///
GTF2H2 221540 x at 7.06E-04 -0.61468
926 PDIA6 208639 x at 0.041702 7.07E-04 4.16 -0.31 1.15862
927 TAX1 BP3 215464 s at 0.041702 7.07E-04 4.16 -0.31 1.46065
928 ASPH 224996 at 0.041746 7.09E-04 4.16 -0.31 1.46610
929 RPL7 239493 at 0.041958 7.13E-04 -4.15 -0.32 -0.60751
930 STAT3 208991 at 0.041958 7.14E-04 4.15 -0.32 1.38419
931 MPZL1 210594 x at 0.042213 7.19E-04 4.15 -0.33 0.60228
932 CCDC59 222792_s_at 0.042213 7.20E-04 -4.15 -0.33 -0.77972
933 LPHN2 206953_s_at 0.042248 7.21 E-04 4.15 -0.33 0.89054
934 SGPL1 212322 at 0.042259 7.23E-04 4.15 -0.33 1.75072
935 SGCB 228584 at 0.042259 7.23E-04 4.15 -0.33 0.76161
936 SIX1 228347 at 0.042259 7.24E-04 4.15 -0.33 0.96750
937 LOC440288 238511 at 0.042259 7.24E-04 -4.15 -0.33 -0.80590
938 SLC16A3 202856 s at 0.042259 7.26E-04 4.15 -0.34 2.11019
939 CES2 209667 at 0.042259 7.26E-04 4.15 -0.34 0.59497
940 PLOD3 202185 at 0.042259 7.27E-04 4.15 -0.34 1.12046
941 APBB2 212985 at 0.042322 7.28E-04 4.14 -0.34 1.11089
942 DAB2 201278 at 0.042324 7.29E-04 4.14 -0.34 1.41625
943 AGPS 225108_at 0.042324 7.30E-04 4.14 -0.34 0.73722
944 FGFR1 211535 s at 0.042476 7.33E-04 4.14 -0.35 0.79203
945 RASL12 219167 at 0.042527 7.36E-04 4.14 -0.35 0.68969
946 SRSF11 213742 at 0.042527 7.36E-04 -4.14 -0.35 -1.51232
947 SSPN 226932_at 0.042615 7.38E-04 4.14 -0.35 1.33139
948 PPAP2A 209147 s at 0.042711 7.41 E-04 4.14 -0.35 1.52277
949 SLC25A43 1557411 s at 0.042906 7.45E-04 4.13 -0.36 1.25584
950 POR 208928 at 0.042906 7.46E-04 4.13 -0.36 1.08216
951 SLC02B1 203472 s at 0.042967 7.47E-04 4.13 -0.36 1.09369
952 FDFT1 241954 at 0.042997 7.49E-04 -4.13 -0.37 -0.65170
953 CHRDL1 209763 at 0.042997 7.51 E-04 4.13 -0.37 2.37080
954 FES 205418 at 0.042997 7.52E-04 4.13 -0.37 0.99814
955 MTUS1 212096 s at 0.042997 7.52E-04 4.13 -0.37 1.28373
956 GTSE1 211040 x at 0.042997 7.52E-04 -4.13 -0.37 -0.85186
957 233716 at 0.042997 7.53E-04 -4.13 -0.37 -0.30187
958 SPTLC2 225095 at 0.043159 7.56E-04 4.13 -0.37 1.09321
959 POLH 233852 at 0.043365 7.61 E-04 -4.12 -0.38 -0.53818
960 INMT 224061 at 0.0436 7.66E-04 4.12 -0.39 1.08039
961 NFKBIA 201502 s at 0.043663 7.69E-04 4.12 -0.39 0.79837
962 MARCKS 201669 s at 0.043663 7.69E-04 4.12 -0.39 1.40722
963 PEPD 202108 at 0.043663 7.59E-04 4.12 -0.39 0.84768
964 C5orf34 229886 at 0.043667 7.71 E-04 -4.12 -0.39 -0.63004
965 SLC2A14/// 0.043667 4.12 -0.39
SLC2A3 216236 s at 7.71 E-04 0.87871
966 PWWP2B 238046 x at 0.043711 7.72E-04 -4.12 -0.39 -0.37729
967 TOLLIP 217930 s at 0.04375 7.74E-04 4.12 -0.40 0.86476
968 CYBRD1 222453 at 0.043836 7.76E-04 4.11 -0.40 0.93710
969 KCND3 215014 at 0.043836 7.77E-04 4.11 -0.40 0.39045
970 HSPB11 215691 x at 0.043837 7.78E-04 -4.11 -0.40 -0.73457
971 PVRL2 225418 at 0.043837 7.79E-04 4.11 -0.40 0.72950
972 LOC100128 0.043971 -4.11 -0.41
074 228203 at 7.82E-04 -0.43042
973 CCDC163P 236900 x at 0.044265 7.88E-04 -4.11 -0.41 -0.72876
974 1558048 x at 0.044265 7.89E-04 -4.11 -0.41 -3.66477
975 COL6A5 1553834 at 0.044265 7.89E-04 4.11 -0.41 2.08746
976 C20orf160 231991 at 0.044265 7.90E-04 4.11 -0.42 0.80600
977 227061 at 0.044351 7.93E-04 4.11 -0.42 2.05333
978 EPS8 202609 at 0.044415 7.96E-04 4.10 -0.42 1.87325
979 RPL18P11 222297 x at 0.044415 7.97E-04 -4.10 -0.42 -0.38515
980 SGPL1 212321 at 0.044415 7.97E-04 4.10 -0.42 1.49785
981 PLXND1 38671 at 0.044415 7.98E-04 4.10 -0.42 1.10655
982 CISH 223961 s at 0.044415 7.98E-04 4.10 -0.42 1.33105
983 232496 at 0.044429 7.99E-04 -4.10 -0.43 -0.32793
984 CLEC11A 205131 x at 0.044556 8.02E-04 4.10 -0.43 0.76014
985 BGN 201262 s at 0.044617 8.04E-04 4.10 -0.43 0.62513
No. Gene* Probe ID** Adj. p value P value f B Log FC
986 232970 at 0.044617 8.06E-04 -4.10 -0.43 -0.47986
987 BSCL2 208906 at 0.044617 8.06E-04 4.10 -0.43 1.16053
988 PLAUR 210845 s at 0.044617 8.07E-04 4.10 -0.43 1.37404
989 PARD6G 227204 at 0.044617 8.08E-04 4.10 -0.44 0.72342
990 SARNP 229069 at 0.044617 8.08E-04 -4.10 -0.44 -0.79063
991 P4HA2 202733 at 0.044617 8.09E-04 4.10 -0.44 2.21085
992 PRSS23 202458 at 0.044617 8.10E-04 4.10 -0.44 1.63929
993 EFE P1 201843 s at 0.044622 8.10E-04 4.09 -0.44 2.00833
994 DCBLD2 230175 s at 0.044701 8.13E-04 4.09 -0.44 0.92747
995 FGFR10P2 233898 s at 0.044702 8.14E-04 -4.09 -0.44 -0.77343
996 COL4A2 211964 at 0.0449 8.18E-04 4.09 -0.45 2.57163
997 SLIT2 230130 at 0.045002 8.21 E-04 4.09 -0.45 1.07821
998 GUCY1 B3 211555 s at 0.045002 8.22E-04 4.09 -0.45 0.74285
999 SFXN1 218392 x at 0.045002 8.22E-04 -4.09 -0.45 -1.20094
1000 GFPT1 202721 s at 0.045059 8.27E-04 4.08 -0.46 0.63209
1001 LRCH4 37796 at 0.045059 8.28E-04 -4.08 -0.46 -0.57108
1002 USP33 214843 s at 0.045059 8.28E-04 -4.08 -0.46 -0.87469
1003 CALD1 212077 at 0.045059 8.29E-04 4.08 -0.46 1.75811
1004 ANAPC4 226917_s_at 0.045059 8.29E-04 -4.08 -0.46 -0.79771
1005 1556297 a at 0.045059 8.30E-04 -4.08 -0.46 -0.32685
1006 ARHGEF10 0.045059 4.08 -0.46
L 221656 s at 8.31 E-04 0.80198
1007 KLF2 226645 at 0.045059 8.31 E-04 -4.08 -0.46 -0.36973
1008 RNF185 224750 at 0.045059 8.31 E-04 4.08 -0.46 0.76875
1009 CREBL2 201988 s at 0.045059 8.32E-04 4.08 -0.46 1.27767
1010 240595 at 0.045127 8.34E-04 -4.08 -0.47 -0.55827
1011 DAP 201095 at 0.045127 8.35E-04 4.08 -0.47 0.99144
1012 DNAJB4 20381 1 s at 0.045127 8.35E-04 4.08 -0.47 0.47665
1013 230598 at 0.045144 8.36E-04 -4.08 -0.47 -1.04731
1014 MCAM 211340 s at 0.045151 8.40E-04 4.08 -0.47 1.07281
1015 FAM111A 239368_at 0.045151 8.41 E-04 -4.08 -0.47 -0.54737
1016 GIGYF2 212260_at 0.045151 8.41 E-04 4.08 -0.47 0.78056
1017 SLC02B1 211557 x at 0.045151 8.41 E-04 4.08 -0.47 1.03221
1018 C11 orf31 1557801 x at 0.045151 8.41 E-04 -4.08 -0.47 -0.49384
1019 OCRL 208316 s at 0.045151 8.42E-04 4.08 -0.47 0.35153
1020 LOC643733 240890 at 0.045151 8.42E-04 -4.08 -0.48 -1.64382
1021 WIPI1 203827 at 0.045522 8.50E-04 4.07 -0.48 1.42805
1022 GALNT2 217788 s at 0.045522 8.51 E-04 4.07 -0.48 1.33054
1023 NET1 201830 s at 0.045522 8.52E-04 4.07 -0.49 1.39469
1024 ABL2 231907 at 0.045534 8.54E-04 4.07 -0.49 1.03604
1025 FAM86B1 65585 at 0.045534 8.55E-04 4.07 -0.49 0.55531
1026 KCNE4 1552507 at 0.045534 8.55E-04 4.07 -0.49 1.32324
1027 QKI 212262 at 0.045534 8.56E-04 4.07 -0.49 1.37609
1028 CSRP1 200621 at 0.045534 8.56E-04 4.07 -0.49 0.76464
1029 GALNT3 203397 s at 0.045648 8.59E-04 -4.07 -0.49 -0.66263
1030 ASPRV1 240017 at 0.04568 8.61 E-04 -4.07 -0.50 -0.40740
1031 ANG 205141 at 0.04568 8.62E-04 4.07 -0.50 0.62974
1032 SLC35E1 222263 at 0.04568 8.62E-04 4.07 -0.50 0.73432
1033 CENPK 222848 at 0.045756 8.66E-04 -4.06 -0.50 -1.23457
1034 ERG 213541 s at 0.045756 8.67E-04 4.06 -0.50 0.90407
1035 SFI1 214402 s at 0.045756 8.67E-04 -4.06 -0.50 -0.57672
1036 TRIO 209011 at 0.045756 8.68E-04 4.06 -0.50 0.44602
1037 243144 at 0.045756 8.68E-04 -4.06 -0.50 -0.39313
1038 227929 at 0.045756 8.69E-04 4.06 -0.50 0.61332
1039 CALCRL 206331 at 0.045756 8.70E-04 4.06 -0.51 1.16930
1040 RNF24 204669 s at 0.045756 8.70E-04 4.06 -0.51 0.86679
1041 FCRLB 238452 at 0.04578 8.72E-04 4.06 -0.51 0.70758
1042 COL5A2 221730 at 0.04587 8.74E-04 4.06 -0.51 3.05045
1043 CLK1 214683 s at 0.045958 8.77E-04 -4.06 -0.51 -1.01097
1044 NCRNA001 0.045958 -4.06 -0.51
06 238104 at 8.78E-04 -0.63551
1045 KAZ 213478 at 0.045958 8.78E-04 4.06 -0.51 0.78762
1046 OSBPL1A 208158 s at 0.046122 8.82E-04 4.05 -0.52 0.79143
1047 DMPK 217066 s at 0.046133 8.84E-04 -4.05 -0.52 -0.38643
1048 ZFPL1 209428 s at 0.046133 8.84E-04 4.05 -0.52 0.47735
1049 TM4SF1 215034 s at 0.046133 8.85E-04 4.05 -0.52 1.46268
1050 TECPR2 204308 s at 0.046279 8.91 E-04 4.05 -0.53 0.68863
1051 DCP2 244777 at 0.046279 8.91 E-04 -4.05 -0.53 -0.86906
1052 TPSB2 207134 x at 0.046279 8.91 E-04 4.05 -0.53 1.68695
No. Gene* Probe ID** Adj. p value P value t B Log FC
1053 UACA 223279 s at 0.046279 8.92E-04 4.05 -0.53 1.06752
1054 PRELP 228224 at 0.046279 8.92E-04 4.05 -0.53 1.26263
1055 GANAB 214626 s at 0.046348 8.95E-04 4.05 -0.53 0.64013
1056 CCDC47 222432 s at 0.046348 8.97E-04 4.05 -0.53 1.04044
1057 C1orf228 238365 s at 0.046348 8.98E-04 -4.05 -0.53 -1.01107
1058 LDOC1 204454 at 0.046348 8.98E-04 4.05 -0.54 0.76728
1059 237034 at 0.046348 8.98E-04 -4.05 -0.54 -0.54217
1060 LOC100287 0.046348 4.05 -0.54
081 228231 at 8.99E-04 0.82231
1061 WBP5 217975 at 0.0463474 9.02E-04 4.04 -0.54 1.75601
1062 USP2 230965 at 0.046474 9.03E-04 -4.04 -0.54 -0.41630
1063 AMFR 202204 s at 0.0463474 9.04E-04 4.04 -0.54 0.52031
1064 CREBL2 201989 s at 0.046631 9.07E-04 4.04 -0.54 0.67683 065 VPS35 222388 s at 0.046739 9.12E-04 4.04 -0.55 0.62900
1066 227623 at 0.046739 9.12E-04 4.04 -0.55 1.26562
1067 SLC24A6 218749 s at 0.046739 9.12E-04 4.04 -0.55 0.89281
1068 CCDC88C 231288 at 0.04694 9.17E-04 -4.04 -0.55 -0.50800
1069 FLJ33630 235628 x at 0.046961 9.18E-04 -4.04 -0.56 -0.47257
1070 C8orf58 227263 at 0.047045 9.22E-04 4.03 -0.56 0.62535
1071 C8orf59 226165 at 0.047045 9.22E-04 -4.03 -0.56 -0.97654
1072 RALBP1 202845_s_at 0.047045 9.25E-04 4.03 -0.56 0.91530
1073 RPL31 221593 s at 0.047045 9.25E-04 -4.03 -0.56 -1.05920
1074 TRIOBP 202795 x at 0.047045 9.26E-04 4.03 -0.56 0.56788
1075 SH2B3 203320 at 0.047045 9.26E-04 4.03 -0.56 1.39831
1076 EHBP1 L1 91703 at 0.047045 9.26E-04 4.03 -0.56 1.09475
1077 MS4A4A 224357 s at 0.047173 9.29E-04 4.03 -0.57 1.52256
1078 CRTAP 1555889 a at 0.047408 9.35E-04 4.03 -0.57 1.18669
1079 SERINC3 221473 x at 0.047416 9.36E-04 4.03 -0.57 1.20288
1080 CLDN11 228335 at 0.047508 9.39E-04 4.03 -0.58 1.91120
1081 ZAK 223519 at 0.047508 9.39E-04 4.03 -0.58 1.19771
1082 232853 at 0.047527 9.41 E-04 -4.02 -0.58 -0.40602
1083 CFHR2 206910 x at 0.047553 9.42E-04 4.02 -0.58 0.72168
1084 KCNJ8 205303 at 0.047706 9.46E-04 4.02 -0.58 1.54215
1085 APLP2 208248 x at 0.047754 9.48E-04 4.02 -0.59 0.98665
1086 ATHL1 219359 at 0.048208 9.58E-04 -4.02 -0.60 -1.19151
1087 C1orf85 225401 at 0.048338 9.61 E-04 4.01 -0.60 1.53553
1088 PPARG 208510 s at 0.04865 9.68E-04 4.01 -0.61 0.86096
1089 ALKBH5 1553101 a at 0.048693 9.70E-04 4.01 -0.61 1.11688
1090 RPS8 200858 s at 0.048693 9.71 E-04 -4.01 -0.61 -0.50571
1091 NCSTN 208759 at 0.048698 9.72E-04 4.01 -0.61 0.68925
1092 RB S1 207266 x at 0.048825 9.75E-04 4.01 -0.61 1.62089
1093 FZD5 221245 s at 0.048973 9.81 E-04 4.00 -0.62 1.07337
1094 PRKCI 209678 s at 0.048973 9.81 E-04 4.00 -0.62 0.92949 095 ADA TS1 222162 s at 0.048973 9.82E-04 4.00 -0.62 1.38996
1096 RNH1 206050 s at 0.048973 9.82E-04 4.00 -0.62 1.634853
1097 MATK 206267 s at 0.049132 9.86E-04 4.00 -0.62 0.65930
1098 EPHB2 211165 x at 0.049132 9.87E-04 4.00 -0.62 0.61647
1099 LOC100288 0.049156 4.00 -0.62
263///LOC64
4617 225653 at 9.88E-04 0.41504
1 100 PECA 1 208981 at 0.049 64 9.89E-04 4.00 -0.63 1.19427
1101 CFI 1555564 a at 0.049164 9.92E-04 4.00 -0.63 1.01859
1102 CYB5R3 1554574 a at 0.049164 9.92E-04 4.00 -0.63 0.89009
1 103 TPSAB1 210084 x at 0.049164 9.93E-04 4.00 -0.63 1.52044
1104 PDLIM5 203242 s at 0.049164 9.94E-04 4.00 -0.63 0.71526
1105 DOLK 204488 at 0.049164 9.94E-04 4.00 -0.63 0.74203
1106 SEMA6D 226492 at 0.049194 9.98E-04 4.00 -0.63 1.20226
1107 MCA 210869 s at 0.049194 9.99E-04 4.00 -0.63 1.09217
1108 UBE2QL1 226612 at 0.049194 9.99E-04 4.00 -0.64 1.14961
1109 ACE 227463 at 0.049194 9.99E-04 4.00 -0.64 1.69530
1110 ZNF320 241704 x at 0.049194 1.00E-03 -4.00 -0.64 -0.42830
1111 SMARCA1 203875 at 0.049194 1.00E-03 3.99 -0.64 0.79801
1112 GBGT1 231780 at 0.049194 1.00E-03 3.99 -0.64 0.72464
1113 235986 at 0.049194 1.00E-03 -3.99 -0.64 -0.45048
1114 KDELR1 200922 at 0.049194 1.00E-03 3.99 -0.64 1.50659
1115 FCRL1 243968 x at 0.049194 1.00E-03 -3.99 -0.64 -1.87102
1116 TAPT1 226735 at 0.049194 1.00E-03 -3.99 -0.64 -0.42542
1117 CDKN1A 202284 s at 0.049194 1.01 E-03 3.99 -0.64 1.39461
1118 ETV5 203349 s at 0.049221 1.01 E-03 3.99 -0.64 0.57709
No. Gene* Probe ID** Adj. p value P value f B Log PC
1119 STAP1 220059 at 0.049241 1.01 E-03 -3.99 -0.64 -1.59671
1120 PDIA6 207668 x at 0.049483 1.01 E-03 3.99 -0.65 1.1 1859
1121 MYO10 201976 s at 0.049483 1.01 E-03 3.99 -0.65 1.27823
1 122 ITGB5 214020 x at 0.049685 1.02E-03 3.99 -0.65 0.72844
1123 ATP5L 208745 at 0.049685 1.02E-03 -3.99 -0.65 -0.73769
1 124 RNF19B 213038 at 0.049693 1.02E-03 3.99 -0.66 1.30812
1125 AUTS2 212599 at 0.049693 1.02E-03 3.99 -0.66 1.32327
1126 AOX1 205083 at 0.049716 1.02E-03 3.98 -0.66 1.37931
1127 CHD2 228999 at 0.049826 1.03E-03 -3.98 -0.66 -1.18763
1128 BAIAP2L2 228876 at 0.049826 1.03E-03 -3.98 -0.66 -0.49610
1129 TTC39B 242477 at 0.049873 1.03E-03 -3.98 -0.66 -0.97680
1 130 FILIP1 L 1554966 a at 0.04997 1.03E-03 3.98 -0.67 1.57994
1131 TMBI 1 217730 at 0.04997 1.03E-03 3.98 -0.67 1.05170
1132 COL15A1 203477 at 0.04997 1.04E-03 3.98 -0.67 2.82957
1133 Sep-11 201308 s at 0.04997 1.04E-03 3.98 -0.67 0.38785
1134 SH2D1A 211211_x_at 0.04997 1.04E-03 -3.98 -0.67 -1.34832
1135 KIF1 B 225878 at 0.04997 1.04E-03 3.98 -0.67 1.00363
1136 GPAA1 215690 x at 0.04997 1.04E-03 3.98 -0.67 0.51529
1137 NANS 218189 s at 0.04997 1.04E-03 3.98 -0.67 0.72916
1 138 COL18A1 209082 s at 0.04997 1.04E-03 3.98 -0.67 1.34108
* Gene symbol as approved by the HUGO gene nomenclature committee (HGNC)
Probe Set ID's from Affymetrix GeneChip Human Genome U133 Plus 2.0 array, from Affymetrix Inc, Santa Clara, USA
EXAMPLE A
Supervised learning algorithms and their application towards predictive modelling and patient stratification in a cohort of chemotherapy-sensitive/resistant Hodgkin's Lymphoma patients
Abstract
Background
The development of rationalised prognosticators for triaging of Hodgkin's Lymphoma (HL) patients into chemotherapy sensitive and resistant groups prior to treatment would have a significant impact upon the clinical management of these individuals. Gene Expression Omnibus (GEO) is a data repository of DNA microarray experiments varying in number, conditions and tissue types. It thus represents an excellent resource for biomarker discovery programmes and model datasets in which to construct and validate potential classification algorithms. Artificial neural networks (ANN) have been shown to be powerful tools that can develop classifiers capable of generalising well to unseen data. They may therefore have clinical utility as prognosticators for chemotherapy response. This study examines expression data taken from the microarray analysis of 130 HL patient core biopsies (pre-treatment) whose clinical outcome to chemotherapy was subsequently determined. The development of ANN classifiers for prognostication was explored. Results
GSE17920 expression series was parsed by GE02R into data structures enabling statistical interrogation by LIMMA (Linear Models for Microarray Analysis) of 92 sensitive and 38 resistant microarray analyses from HL pre-treatment core biopsies. Sixteen differentially expressed probe sets (biomarkers) were identified; false discovery rate (FDR) < 5%. These candidates were used to develop binary classifiers of either chemo- sensitive or chemo-resistance. 30% of samples were used for training (n=39), 10% for testing (n=13) and 60% of samples (n=78) as an independent validation dataset. Classifiers were developed in which 100%, 92% and 91 % of training, testing and validation samples were correctly assigned with ROC (Receiver Operating Characteristic) plots producing an AUC (Area Under the Curve) of 0.926.
Sixteen outliers were identified that had consistently poor levels of prediction. These samples were separated from the main cohort and two groups consisting of outliers (Group 16) and the remaining samples (Group 114) were constructed. Differential gene expression between chemo-sensitive and chemo-resistant samples within Group 16 and Group 114 was determined by resubmission to GE02R and LIMMA. A total of 1138 (Table C) and 5344 (Table A) probe sets(biomarkers) for Group 16 and Group 114, respectively, were identified as being differentially expressed (FDR≤ 5%). The original 16 gene probe set (Table B; identified from using all 130 samples) remained significantly different for Group 114 (FDR≤ 5%) and models could be produced in which all predictions (n=114) were correctly classified. For Group 16 only 1/16 of the originally identified gene probe sets remained significant. Using an alternative panel taken from the 1138 significant probe set identified as being significant (FDR < 5%), classifiers were constructed in which all outlier samples (n=16) were accurately assigned to their respective chemo-sensitive or chemo-resistant groups.
Conclusion ANN can be developed into binary classifiers capable of assigning pre-treatment HL patient expression profiles into either chemo-sensitive or chemo-resistant categories. Sampling with replacement strategies enable outliers to be identified that may indicative of genetic sub-groups. Isolating outliers from the main cohort of samples combined with re-training can improve predictive performance for both outlier and non-outlier groups regarding the probability of chemo-response.
Background
From a therapeutic perspective the management of patients with Hodgkin's Lymphoma (HL) represents a challenging paradigm. As observed in other cancer groups, this is primarily manifested as a variation in the clinical response to chemotherapeutic intervention and presents phenotypically as one of three broad categorical groups: a) response; b) partial response; c) no response [1], [2]. This issue is further compounded by potential side effects elicited by toxicity to non-tumour cells and consequently introduces an additional complication to patient treatment protocols [3], [4], [5]. There is therefore an urgent need for molecular markers that are indicative for appropriate dosing
strategies directed specifically towards the individual patient in addition to assays capable of identifying potential resistant/sensitive responses.
At the heart of these clinical issues is the genetic heterogeneity exhibited not only between individual patients with respect to their genomic DNA sequence, but also the somatic mutations that might arise as part of the evolutionary development of the tumour [6]. [7], [8]. With respect to the latter, further complexity is exhibited in that mutations have been classified into two broad groups: a) "driver" mutations in which key cellular pathways are abrogated and begin to positively subvert the cellular machinery towards more aggressive phenotypes and b) "passenger" mutations which do not actively promote or abrogate the tumorigenic process but represent "background" noise [9], [10]. The ability to demarcate between mutations that drive aggressive phenotypes from those that play no significant role in altering the clinical response to chemotherapy would provide potentially useful diagnostic assays with utility for triaging patients into those that may benefit from treatment versus those who are unlikely. With appropriate quantitation, characterisation and validation studies, these markers may also assist in dosing strategies for sensitive patients.
There have been several publications providing independent corroborative support to the existence of genetic sub-types within tumours such as breast [11], [12]; lymphoma [13]; prostate [14]. Such heterogeneity might be indicative therefore of different aetiological pathways for carcinogenesis and consequently that alternative strategies may be necessitated to treat patients with alternate tumour expression patterns. Massively parallel examination of transcriptional activity in a temporal/spatial manner using technologies such as DNA microarrays; RNA-sequencing affords the possibility of identifying expression patterns that might be correlated to patient sensitivity/resistance to chemotherapy. This rationale has been shown with several therapeutic agents in which for example Her2/Neu expression is ascertained prior to the commencement of Herceptin administration [15], or ER status is determined prior to tamoxifen treatment [16]. In colorectal cancer mutational screening has now been recommended by the FDA to establish the status of KRAS mutations prior to commencement of therapy to cetuximab/panitumumab - these therapeutics are known inhibitors of the EGFR pathway of which KRAS is an integral component in the signalling pathway [15]. While the biological/ pharmaceutical reagents listed above are known to target specific and well characterised pathways to elicit their effect, it is possible that not all downstream
elements (including those responsible for both augmentation and repression of the therapeutic effect) have been fully elucidated.
Identifying pathways that either directly or indirectly attenuate the therapeutic effect might have potential value from several perspectives. Firstly these molecular targets could form the foundation of novel diagnostic assays capable of identifying patients that have increased resistance to treatment [17]. Such tools would rationalise clinical decision making processes to move the patient towards alternate forms of therapeutic intervention with an increased chance of success. Secondly an understanding of the interplay between genetic pathways and their controlling elements that allow patients to be permissive to therapeutic intervention might facilitate the development of novel drug/biological treatments [18]. Finally the possibility exists, that elucidation of the effector pathways that manifest as either sensitive or resistant phenotypes could be another step towards the creation of assays capable of determining the appropriate dosing strategy for patients.
Massively parallel interrogation of gene expression patterns offers a useful methodology in which to identify biomarkers that could be exploited to classify patients into "responders", "partial responders" and "non-responders". In conjunction with appropriate validation studies (e.g. retrospective analysis on archival material; prospective randomised clinical trials) the robustness of such biomarkers can be tested and refined. Through such co-ordinated strategies, the development of companion diagnostics capable of aiding in the clinical management of patients including treatment options might be feasible. There is not only a need for the development of diagnostics targeted towards therapeutic outcomes but also characterisation of the molecular pathways that these candidate biomarker genes are involved in as drug resistance may also be interconnected to pathways linked to side effects associated with treatment.
Given the clinical utility that could be afforded by having pre-treatment/early treatment diagnostic tests for patient therapeutic response, there are developmental phases that would need to be addressed prior to clinical deployment. Although not exhaustive, these can be broadly categorised as: a) biomarker (candidate) discovery; b) statistical interrogation to identify candidates for validation; c) computational modelling using multivariate analytical techniques to assess biomarker predictive performance; d) ranking the importance of biomarkers to predictive performance; e) application of new information to allow further modelling of drug response pathways; f) validation in
prospective clinical studies to test model/biomarker robustness; g) potential refinement of models to account for the molecular heterogeneity of tumour cells from patient response data [19]. All phases of the biomarker discovery process represent significant challenges including most notably acquisition of appropriate clinical samples for validation studies and the time/resources needed to corroborate initial findings. Computational modelling has the potential to contribute significantly to testing the robustness of potential biomarkers prior to moving towards more costly and resource consuming validation studies. Adaptive learning algorithms represent powerful computational tools that have been applied with good effect to identify novel biomarkers associated with various phenotypes. These include for example pathological tumour grade [20], [21], disease staging in cancer patients [22] and resistance versus sensitive expression patterns for both cell lines and patient clinical samples [23]. Artificial neural networks represent one such class of computational algorithms that have been applied to a variety of post genomic high throughput data sources for predictive modelling. There are several advantages to ANN which include: a) the ability to produce models capable of generalising well with new data; b) enable a potential ranking of predictor variables to assess the relative importance that each contributes towards model accuracy; c) the ability to use non-linear mathematical computations to identify inter-relationships between the variables to produce robust and accurate models [24], [20]. The disadvantages of ANN include the fact that the mathematical relationships which are developed between the input variables and output predictions may be difficult to rationalise (i.e. they are non-linear in nature and thus gain the term "black box"), the time taken to train ANN and the issue of "memorisation" or over fitting the data so that the network begins to model "noise" rather than signal [25]. This latter limitation can be overcome to some degree through the introduction of additional samples for testing predictive performance, network regularization or sampling with replacement techniques. ANN are mathematically modelled upon the neural network systems of higher biological organisms. Just as learning and memory systems are composed of a series of interconnecting neurons capable of receiving and transmitting impulses in response to specific stimuli, ANN are designed to respond in an analogous manner although the architecture is vastly simplified compared to their biological counterparts. In relation to the structural architecture of an ANN, a variety of forms have been explored for their ability to classify biological data with good predictive capability. One type that has shown
extremely good performance for data classification is the multi-layer perceptron ( LP) and it has been used with good effect to develop trained models with excellent prediction for new (blind) data [20]. The basic structure of a MLP is composed of three layers: a) input neurons representing the values of the variables used for training the ANN (e.g. microarray expression values); b) hidden layer neurons that receive the signal through weighted links and then subsequently propagate the transformed values through a series of activation functions (e.g. logistic sigmoid, exponential, softmax); c) output neurons in which the signal is propagated through a final series of activation functions to make a classification response. The input node is normally devoid of an activation function and is therefore propagated unmodified after the numerical variable is scaled (0, 1). Two additional nodes are added to the hidden layer and output layer which allow the transformation result of an activation function to be moved towards the right or left of the x-axis. This is achieved through having the input value set to 1 and the weighted link is varied and results in the production of outputs with reduced error between the predicted and actual values for training set samples [26].
The MLP is an example of a feed forward propagation network in which the input signal is moved in a unidirectional manner from the input towards the output layer. The error function between the network predicted and actual value is calculated and this error value is then propagated back from the output neurons towards in the input layer through modification of the weight values. This modification in weight is given by the formula shown in figure 1C and represents a function of learning rate, error and initial input value. Weighted links can be either updated as a batch once all training samples have been propagated through the network or alternately each time an individual training sample fully propagates through the learning algorithm (incremental). In this manner the ANN adapts through iteration to minimise the error between network predicted and actual value, until the error value reaches zero or alternately some pre-set stopping criteria (e.g. early stopping in which a test set has been exploited and the error rate between the training and testing samples begins to diverge) is reached.
ANN have been used to interrogate DNA microarray datasets for classification of a variety of tumour types with high rates of accuracy [27]. Given our group's interest in the issue of therapeutic resistance in cancer patients we wanted to explore whether ANN could be utilised to effectively discriminate patients into either chemotherapy sensitive or
resistant cohorts from patients with known clinical outcomes based upon quantitative values obtained from normalised gene expression data. It is important that models showing good accuracy for classification of training samples have the network predict upon cohorts of independent validation datasets to ascertain the potential robustness of the model. If sufficiently robust (i.e. has excellent predictive capability for blind samples) then such an approach could provide a basis in which to begin to select genes for their potential diagnostic/prognostic capability.
The development of computational models with good predictive capability is highly contingent upon the quality of the input variables and the samples that are used for development (i.e. training/testing sets). The ability to triage microarray datasets for genes with a high probability of being differentially expressed between the appropriate target groups (i.e. drug resistant/sensitive) would represent an important first step in selecting robust biomarkers that might form the foundation of novel diagnostic/prognostic tests although this does not of course guarantee that they will be useful as predictor variables. While ANN are powerful data mining tools and predictive models, they are strongly dependent upon the samples (and therefore the gene expression patterns) that are used in model development [22]. The premise of model development is that training and testing samples represent a "consensus" molecular expression pattern that is indicative of resistant and sensitive populations. Issue may arise therefore if non-consensus expression patterns occur within the population that is utilised as either a training or testing sample. Such "non-consensus" expression patterns (or outliers) existing within the training or testing sample sets may result in skewing the developing models towards algorithms that might be sub-optimal for the general population [28]. While outliers might represent systematic artefacts of the system (e.g. samples that may have been collected/stored incorrectly; poor experimental run; ANN predictive models that are unable to accurately account for all the variation within the variables submitted for model building) there is also the possibility that they may represent distinct biological entities that have arisen independently of the main cohort. If this is the case then the ability to identify, develop and characterise alternate models which rely on alternate biomarkers that are more representative of the outlier cohort will be important both to the clinical management of patients and therefore treatment selection.
Gene Expression Omnibus (GEO) is a data repository containing experimental results from over 140,000 microarray experimental analyses [29], [30]. GEOquery is an open source algorithm specifically constructed to act as an interface between the datasets
stored in GEO and data interrogation and feature extraction by exploiting bioinformatic tools created as part of the Bioconductor project [31], [32]. These algorithms have been written in R language and GEOquery provides a simple graphical user interface in order to permit access and harnessing of these data interrogation programs without the use of line command language. Limma (Linear Models for Microarray Analysis) is one such suite of algorithms that is implemented by GEOquery to perform multivariate statistical testing in order to identify differential expression patterns from microarray data. It will calculate p-values and adjusted p-values ("q-values") through multiple-testing correction methodologies including the widely used Benjamini and Hochberg approach [33]. As such the user has access to a powerful suite of statistical interrogation tools capable of facilitating the rapid triage of differentially expressed genes.
In the current study we have chosen to exploit gene expression data using microarray datasets available from the Gene Expression Omnibus data repository as systems to explore the characteristics of predictive model development by ANN. Given this group's interest in chemotherapy resistance we have chosen to focus upon a published dataset taken from Hodgkin's lymphoma patients in whom their clinical outcome to chemotherapy treatment has been ascertained using standard clinical criteria as either responsive or resistant [34].
Using open source algorithms to undertake a pre-screening exercise to select genes that are differentially expressed (FDR adjusted p-value < 5%), we have taken these potential biomarkers and applied them as targets for building an array ANN models. We have explored potential effects on predictive accuracy by using randomised populations to form training, testing and validation sample sets. We present data on our findings regarding the identification of outliers from this cohort that consistently fail to predict well but using alternate biomarker expression patterns for this sub-group that predictive accuracy can be increased. Finally we show some initial findings regarding the relative importance ranking of biomarkers used in prediction and how this may vary between training, testing and validation datasets and thus represents another compounding effect for biomarker selection and downstream validation.
Results & Discussion
(a) Analysis of full (130 patient) data set and identification of Group 114 main cohort Selection of candidates for ANN model development
We chose to exploit GEO and its query tools in order to interrogate microarray datasets for potential candidates that had the highest potential for differential expression between chemotherapy responding and resistant HL patients. Although alteration in expression pattern may elicit powerful information regarding the molecular pathways that are abrogated during oncogenesis and disease progression, such differential expression may also provide translational utility with respect to clinical outcomes following chemo- therapeutic intervention. These tools could be exploited as the basis of a predictive diagnostic assay enabling the rationalisation of the clinical decision making process for placing individual patients on specific treatment regimens. With this goal in mind we chose therefore to explore whether these expression patterns might also have potential utility as predictive biomarkers for ANN based classification algorithms for patient response to treatment. Expression series GSE17920 was selected as a model dataset for algorithm development. Core biopsies were sampled from patients with Hodgkin's Lymphoma (n=130) of which their clinical response pattern to chemotherapy treatment was ascertained. Patients were categorised to be either chemo-resistant (n=38) or chemo- sensitive (n=92) and thus provided an extremely useful cohort of data in which to develop predictive clinical models indicative of therapeutic failure. GEOquery requires users to identify at least two (with a maximum of 10) groups of samples in order to perform statistical interrogation. We classified expression data as either "resistant" or "sensitive" to chemotherapy and thus conducted statistical analyses based upon a two group classifier. GEO datasets necessitate that user data is normalised enabling cross comparison within a given experimental series with median centred data being strongly indicative of normalisation of the expression dataset. To ensure that this was the case we used GEOquery to produce boxplots of the microarray expression values for all 130 samples (Figure 1). The median values (black boxes) appear to strongly co-align for all samples suggesting that the dataset is normalised allowing cross comparison.
GEOquery was then utilised to identify genes with the highest probability for differential expression as reported by their raw p-value and q-values (adjusted p-values (Benjamini and Hochberg multiple-testing correction) with the associated q-value indicative of the likelihood of the false discovery rate (FDR)). We made an arbitrary decision to concentrate our attention on genes for ANN model development that resulted in q-values of <0.05. Sixteen probe sets (gene biomarkers) were identified that fulfilled this criterion and are presented in Table 1 with their associated gene identities, log2 fold change, raw p-values, t-statistic and B-statistic. With respect to the data for Log2 fold change, positive values are indicative of an overall increase in mean expression value for the success group compared to the failure cohort (i.e. expression level for success group > failure group). The converse is true for log2 fold change expression values that possess a negative sign. In this case it is indicative of a mean increase in expression value for the patients who fail their treatment compared to patients who showed chemotherapy response (i.e. gene expression level for the failure group > success group).
Development of ANN classifiers
ANN have been shown to produce models that are capable of generalising well with new unseen ("blind") validation data. We wished to explore whether the differential expression patterns of the 16 gene biomarkers with FDR <0.05% could be exploited to develop ANN models with strong predictive capability for discriminating patients as either being chemo- sensitive or chemo-resistant. In order to address this question we established an automated model development process using parameters selected at random in order to both construct and then test the predictive accuracy of the resultant ANN. Architectures were built upon the Broyden-Fletcher-Goldfarb-Shanno (BFGS) optimisation multi-layer perceptron back propagation neural network algorithm and constructed using a variety of activation functions (e.g. logistic, Tanh, Softmax, Identity) for both hidden and output neurons. Two types of calculation (sum of squares; entropy) were exploited to assess classification error between actual and network prediction. The error value was back propagated through the network leading to alteration of the weighted links between input and hidden layers as well as between hidden and output layers. 20,000 models were run per analysis and the top 100 models (with the highest predictive accuracy for training, testing and validation datasets) were kept for downstream data analysis. Expression data for all 16 gene biomarkers from all 130 Hodgkin's lymphoma patients (resistant (n=38); sensitive (n=92)) were utilised to develop models with a strong
classification performance. Training, testing and validation datasets were implemented in order to construct and validate algorithms that had strong capability to generalise well for new data. In order to achieve this goal 30% (n=39) of samples were used for training, 10% (n=13) for testing and 60% (n=78) as part of an independent ("blind") validation set. We wished to explore a number of potential effects of using ANN based classifiers for chemo-response outcomes. These included: 1) whether ANN might be capable of constructing computational models that are able to generalise well for new (validation) data and thus discriminate between sensitive/resistant patients; b) the potential effect that using different samples to form the training, testing and validation datasets had upon classification accuracy including the identification of potential outliers; c) the effect of varying network initialisation (weighted link values) while keeping training, testing and validation samples constant; d) the potential contribution of individual biomarker expression patterns (and therefore their relative ranking position) upon classification accuracy; and e) how individual biomarker rankings might be affected by systematic variations of an individual ANN model.
The application of variable ranking is highly significant to biomarker discovery as most classifiers (e.g. ANN or CART (Classification And Regression Trees)) implement a relative ranking of variable importance that is usually based upon the impact that the variable has towards classification accuracy. These methodologies are used in the selection of biomarkers for subsequent downstream validation studies and thus form an integral component of candidate biomarker triage. Eliciting further information as to how systematic effects may potentially impact upon biomarker ranking is essential as these factors directly impact on biomarker assay development and ultimately for a select cohort of molecules new potential therapeutic targets.
Sample and network seed variation
Several reports that have indicated that subsets of biological/clinical samples may not predict well using the algorithm developed for their classification. These samples are commonly referred to as outliers and they represent an interesting class of variables primarily because they fail to conform to a canonical expression pattern indicative of the group in question. There are a number of factors that could influence the emergence of outlier samples and these might act either in isolation or in concert with each other in order to produce classification errors. Such examples include: a) the outlier in question represents a true biological variant (different genetic class) from that being modelled; b)
there are systematic errors that have impacted the variable's expression value (e.g. sample degradation; analytical preparation; random error). Both effects can result in outlier samples significantly skewing model development from a classifier that generalises well for new biological data to one in which there is strong degradation of classification performance.
Given the potential genetic and/or systematic variation that might influence expression patterns within a given sample, we wished to explore what effect different combinations of samples (and therefore their associated gene expression pattern) might have upon classifier development and ultimately downstream predictive accuracy. To achieve this goal we used 10 number seeds to select different combinations of samples that would form training, testing and validation datasets. In this manner a sample might appear within the training cohort for one number seed and as part of the validation dataset for a different number seed for each of the 10 separate runs. 20,000 models were developed and the top 100 models (as based upon predictive accuracy) were retained.
Table 2 shows the results of models 1-8 obtained from run 5 from a total of 100 models retained after the training process. The percentage of correct classifications predicted by the ANN for all three cohorts (training, testing and validation datasets) is presented. Model 2 for example correctly assigned 100% of patient samples of the training group (n=39) to their respective clinical outcomes i.e. chemo-resistant or chemo-sensitive. 92% (n=13) and 91% (n=78) of testing and validation classifications for the testing and validation datasets respectively were accurately assigned to their clinical outcome groups. The table indicates the method used by each model to determine the error differential between actual and predicted values (sum of square; entropy). Finally the type of activation function used to propagate the learning process from the input layer to the output nodes is also presented.
One statistical measure of a model's ability to accurately discriminate between two classes is the production of a Receiver Operating Characteristic curve which plots the number of true positives (sensitivity) versus false positives (1 -specificity). An inability to discriminate between each respective class would result in a line of 45 degrees and an AUC (Area Under the Curve) of 0.5. A perfect ability by the algorithm to accurately assign each member to its respective without error class would result in a right angle plot and an AUC of 1.0. As a measure of overall performance ROC curves were plotted for all 100 models using classifications results for training, testing and validation datasets in
order to gain an average estimation of model performance within a given run (Figure 3). Model 2 highlighted above produced an AUC of 0.926 indicating a good level of discriminatory power between the two classes of patients. The data would suggest that the 16 gene biomarkers (see Table B) identified initially by GE02R may be useful candidate biomarkers of chemo-sensitivity/chemo-resistance for ANN predictive modelling and therefore warrant further analyses.
For each patient sample (n=130) the number of correct predictions across all 100 models was calculated per run. Next we determined the average percentage classification accuracy for each sample across all 10 runs. Confidence intervals were estimated using a two-tailed t-distribution (a≤ 0.05) with 9 degrees of freedom and is summarised in Figure 4a. There are several samples from both the chemo-resistant (e.g. samples 13, 14, 33) and chemo-sensitive populations (e.g. samples 73, 74, 75) where all ANN models correctly predicted the therapeutic response class of the sample each time a prediction was made. This is in stark contrast to several other samples from the chemo- resistant (e.g. samples 3, 18, 19, 20, 21) and chemo-sensitive (e.g. samples 1 , 23, 50, 90) cohorts which consistently produced low levels of accurate classification by the ANN models. Given the number of models which failed to accurately assign the correct class to these samples we then wished to interrogate these outliers further and potentially gain a better understanding of the influencing factors that can impact classifiers of microarray data. Such characterisation might assist in developing better strategies for biomarker selection that would ultimately form robust predictors of patient therapeutic response.
Next we wished to assess the effect that different initial network weights might have upon the predictive modelling process - and ultimately the effect on classifying outliers. We used the same fixed sample seed value used in run 10 from the "sample seed variation" series such that identical samples would form the training, testing and validation datasets. As before we developed 20,000 models per run with the top 100 models (based on predictive accuracy) being retained for downstream analysis. The number of correct predictions across all 100 models was calculated per run and the average percentage classification accuracy was determined for each sample across all 10 runs. The data is summarised in Figure 4b. It is apparent from both the average values and confidence intervals that varying the initial weightings has very little effect upon the outcome of prediction. If one compares Figure 4a with Figure 4b the data would suggest that the outlier samples still remain challenging to classify by the ANN and that changing either the composition of the training, testing and validation datasets nor altering initial
network weighting values appears to have significant effect upon the classification accuracy of these particular outlier samples. In order to visualise these outliers across all runs for both sample and network seed variation we produced a colour heat map to indicate classification accuracy for a given sample within the chemo-sensitive and chemo-resistant patient populations.
Developing good predictive models capable of classifying HL patient therapeutic response is likely to be contingent upon several factors. As well as systematic parameters such as consistent sample collection, storage, processing and analytical precision, robust modelling will also be contingent upon the identification of biomarkers whose expression pattern is not only stable but specific for the population under study. There is accumulating evidence to suggest that several genetic sub-populations may preside within patient tumour samples as evidence for example within B-cell lymphomas, breast tumours and colorectal cancers. Given the potential for genetic heterogeneity with HL patients and therefore alternate expression patterns that might impact upon individual therapeutic response profile, we wished to explore potential genetic factors in greater detail. To this end we undertook a further series of in-silico characterisation studies to demarcate between potential systematic effects from those that might have a biological basis for the outlier population.
Systematic versus biological effect - sample randomisation and outlier removal
ANN are useful modelling tools that generalise well for the prediction of new data. Through parameterisation of the input variables, parsimonious models can be established that can be robust classifiers. There are however limitations to the application of ANN for biomarker discovery and one of the key challenges facing the field is that predictive models developed by these algorithms are complex, non-linear in nature and consequently difficult to interpret. Given this background we wished to extrapolate upon our previous analyses to elicit information regarding potential systematic artefacts that might be generated by the ANN modelling process versus those that have a specific biological basis capable of being attributed to the outlier population.
The predictive models developed to this point were based upon presentation of samples in a sequential order to the neural network i.e. all chemo-resistant followed by chemo- sensitive patients. Through user specified seeding values random combinations of samples were extracted in order to form training, testing and validation datasets. To
minimise the risk that outlier samples might be potentially the result of positional effects in which the samples were presented to the ANN, we then chose to randomise all 130 samples using three consecutive random seed generators. 10 sample seeds were used to select training (30%), testing (10%) and validation (60%) sets. 20,000 models per sample seed were trained and the top 100 models based upon predictive accuracy were retained. The results are presented in Figure 5 for the outlier samples. A comparison of predictive performance for each of the 16 selected outlier samples for the "Sequential" and "Randomised" sample order is presented. The data would suggest that although there are mean increases in predictive performance for some samples (e.g. Class S 74) none of the improved performances are significant compared to the initial run. This suggested therefore that variation of these samples from the main cohort might reside in explanations other than purely systematic.
To explore this hypothesis further we removed the 16 outliers from the main cohort of 130 of samples to create two populations: Group 114 (main cohort of 114 samples) and
Group 16 (outlier cohort of 16 samples) with both groups containing chemotherapy resistant ("Failure") and chemotherapy sensitive ("Success") patient sample data.
Differential expression patterns between Failure and Success patients from Group 114 and Group 16 were examined by submitting the individual groups to GE02R for comparative analysis. Benjamini and Hochberg multiple correction testing was applied and following statistical processing we concentrated our attention on genes with adjusted p-values having FDR≤ 0.05.
Figure 6 presents the results of genes that were identified by the Bioconducter statistical tools as being differentially expressed between patients who were resistant compared to those who responded to chemotherapy treatment. Data is shown for Group 130, Group 114 and Group 16 and is focused upon genes with adjusted p-values having FDR≤ 0.05. It is interesting to note that when the 16 outlier samples are removed from the main cohort of samples the number of gene biomarkers with adjusted p-values with FDR≤ 0.05 increases from 16 (see Table B; Group 130) to 5344 (see Table A; Group 114) for sensitive versus resistant patients. When one compares the number of genes with adjusted p-values having FDR≤ 0.05 in Group 16 (sensitive versus resistant patients) the number of gene biomarkers that are identified as being differentially expressed increases from 16 (Group 130) to 1138 (see Table C).
Next we asked whether the 16 genes identified originally from all 130 samples (Group 130) after multiple testing corrections were still significant for Group 114 and Group 16. Table 3a and 3b present the results from statistical analysis returned by the Bioconductor series of tools for Group 114 and Group 16 respectively. Examination of the data from Table 3a suggests that all of the genes originally identified from Group 130 remain significant after correction testing. This is in contrast however to Group 16 (outlier samples) in which only one gene out of 16 (C1orf163) remain statistically significant at the FDR < 0.05. We believe that this represents an interesting observation as the outlier population of samples consistently showed a poor level of predictive accuracy by ANN when compared to the main population (Group 114) of samples. One explanation as to why the outlier group may have elicited low predictive accuracy during modelling is that Group 16 may in fact represent a distinct biological cohort with an alternate expression pattern. Given that only one out of 16 genes is significantly different after multiple testing corrections between the chemo-sensitive and chemo-resistant samples it may provide a valid reason as to why poor classification occurred within the outlier group.
Caution must be exercised regarding these conclusions however. The possibility that Group 16 might represent a genetic sub-population is based purely upon an in-silico analysis with no independent validation studies having been conducted to corroborate such a hypothesis. Furthermore the possibility also exists that the outlier population represents normally distributed variation and is merely an artefact of a limited number of computational models (n=600,000) having been searched i.e. sampling variation rather than a biologically driven phenomenon. We wished to explore whether the removal of the outlier samples could potentially lead to increases in predictive accuracy by ANN models for the Group 114 samples. To answer this question we randomised the order of the samples and then initiated model development as indicated previously. 20,000 models were developed per run and the top 100 models (based upon overall predictive accuracy for training, testing and validation datasets) were retained for downstream analysis. We used random sample seeds to select different combinations of training, testing and validation datasets with constant network seed values. In addition we also developed models using random network seeding values while keeping sample seed constant. 10 runs were performed for both sample and network seed variation analyses producing a search space of 200,000 models for each parameter settings (n=400,000 total). 30% (n=35) of samples were used for training, 10% (n=11) for testing and 60% (n=68) as a validation sets for Group 114.
Table 4 presents the results of Run2 (variable sample seeding) for models 1-8. The data would suggest that there is a good level of predictive accuracy for samples that comprise the training, testing and validation datasets. It can also be noted that for three models (Model 2, Model 3 and Model 4) 100% accuracy was achieved for all three sample sets. When we compared the predictive accuracy of all models within Run2 that achieved 100% predictive accuracy for training, testing and validation datasets, 28/100 achieved this level. Interestingly for Run1 , although a high level of predictive accuracy was achieved, no model in the top 100 achieved 100% accuracy for all three datasets (data not shown). Implementing different random seeding values for network initialisation (with constant training, testing and validation sample sets) also produced runs containing models with 100% predictive accuracy for all three sample cohorts.
The results obtained from model development would suggest that by removing the 16 outlier samples from the main cohort of 130 leads to an improvement in predictive performance with some models achieving 100% accuracy for training, testing and validation datasets. One plausible explanation is that Group 16 represents a biologically distinct group of samples (Table 3b) and as such is capable of skewing model development towards non-optimal solutions. Upon the removal of Group 16 from the main body of 130 samples, the ANN is able to generate models from Group 114 in which all expression patterns from both chemotherapy sensitive and resistant patients are accurately classified. Another potential explanation is that the outlier samples do not represent a biologically separate cohort but may represent systematic variants (e.g. sample processing, storage, labelling) that also skew ANN model development towards classifiers that do not generalise well for new blind data e.g. validation data. Such a scenario could be envisioned to negatively impact the search space conducted by neural network optimisation modelling. This could for example result in the number of models having been developed in this study being inadequate in number to successfully identify a model that generalises well for new data structures.
(b) Analysis of Group 16 outliers
Differentially expressed genes between chemo-sensitive and chemo-resistant patients
Finally we turned our attention to the Group 16 outliers and asked whether classifiers could be developed that were able to accurately discriminate chemo-therapy sensitive
and chemo-therapy resistant patient expression profiles. Table 5 shows the top 50 gene biomarkers listed in order of their adjusted p-values from the most (top) to least (bottom) significant. An interesting observation is that of 11/50 (22%) of these genes have been published as having differential expression patterns in response to treatment outcome including for example CD93 (ranked 1st with adjusted p-value < 0.000133) and Neuropilin 1 (ranked 4th with adjusted p-value≤ 0.001086). LAPTM4B (ranked 8thwith adjusted p-value≤ 0.001363) has been implicated in the chemotherapy resistance of breast cancer patients to anthracyclines and is strongly linked to disease recurrence in these patients. Given that association of these genes has been previously linked with chemotherapy response profiles, a potential biological basis for Group 16 samples being outliers compared to Group 114 that possess a distinct expression profile in response to chemotherapy outcome would not be inconsistent with previous published data. Once again we caution that our analyses are limited to an in-silico investigation and therefore cannot corroborate our findings using independent biological verification, but nevertheless we believe that there is persuasive evidence to suggest that this cohort of genes should warrant further investigation.
ANN modelling We made an arbitrary decision to select the first four gene biomarkers with highest adjusted p-values (CD93 molecule (adjusted p-value≤ 0.000133), gap junction protein, delta 3, 31.9kDa (adjusted p-value≤ 0.000167), paired related homeobox 1 (adjusted p- value < 0.000747) and neuropilin 1 (adjusted p-value < 0.001086)) and we used this cohort to explore whether classifiers could be developed with good predictive capability for discriminating chemo-sensitive from chemo-resistant patients in Group 16. To achieve this goal we developed a standard 20,000 model exploratory search analyses combined with retention of the top 100 best performing models based upon predictive accuracy for training, testing and validation samples. Given that there are only 16 samples forming the outlier group we chose to use 30% (n=5) of samples for training, 20% (n=3) for testing and 50% of samples (n=8) for validation. We focused our attention on constructing predictive algorithms using only variation in sample seeding as within this study it appeared to have the most significant impact upon predictive accuracy for sample classification compared to the effect caused by varying network initialisation. 10 runs were conducted with varying network seeds. Table 6 shows the results from Models 1-8 taken from Run! The data indicates that all samples from each cohort are correctly classified suggesting that the expression levels of the four genes identified as being
differentially expressed possess sufficient information to enable accurate discrimination between chemotherapy resistant and sensitive patients. In fact all 100 models from Run1 produced correct classification of samples for training, testing and validation samples (data not shown). In fact this pattern was repeated for all other nine runs with all models showing 100% predictive accuracy with the exception of 5 models (n=1000) which had less than 100% correct classification. This would suggest therefore that these four genes contain sufficient information to discriminate between the chemo-sensitive and chemo- resistant patients within Group 16. How robust these markers/predictive models will be for new data of the "Group 16 type" can only be tested and validated with independent test sets which was not conducted within this study. There may be the possibility therefore that as the genetic variation increases that these classifiers and the biomarkers that are used to develop such algorithms may prove to be either ineffective or require additional biomarkers in order to maintain classification robustness. We next examined whether these four gene targets were significantly different between the treatment failure and success groups for all 130 patients. The adjusted p-values showed that there was no significant difference (FDR≤ 0.05) between the two cohorts (data not shown). This was reinforced by predictive accuracy when these four genes were used to develop classification models for Group 130 samples with variable sample seeding (10 runs with 20,000 models developed per run and retention of the top 100 models based upon predictive performance per run). Figure 7 shows the ROC plot taken from Run6 for Group 130 samples. There is no significant ability of the models to demarcate between patients who respond to their chemotherapy treatment versus those who are resistant using the four most significant genes identified in the outlier Group 16 cohort. This may suggest therefore that these genes have no value for classification when the outlier population is combined with Group 114 samples. Finally we undertook a limited exploration as to whether these four genes were also significant in Group 114. Three genes NRP1 , GJD3 and CD93 were significantly different (as measured by adjusted p-values returned from LIMMA analyses) whereas PRRX1 was not. Using a series of runs (n=2) and varying sample seed to select alternative populations of training, testing and validation groups no significant level of predictive accuracy was achieved. This may suggest therefore that these four genes do possess sufficient information to account for all of the variation (biological and/or systematic) that is present within Group 114. There is a possibility therefore that additional biomarkers may be required from the cohort list in order to develop classifiers that have strong predictive performance.
In summary therefore we present data to suggest that ANN can be effective tools for identifying potential biological outlier sub-groups that have alternate gene expression patterns for chemotherapy response or failure from the main body of samples. Removal of these samples and re-training can result in improved model development and predictive performance for both the main cohort of samples and the outliers. Such a methodology may assist in the identification of novel biomarkers that have clinical utility for triaging HL patients regarding treatment outcomes to their chemotherapy treatment. Only with appropriate downstream validation studies will the robustness of such predictive modelling algorithms including their associated biomarker variables be corroborated. While it goes beyond the context of this current study we believe that it is important to at least raise the issue of biomarkers that are used for model development. As was observed in the context of this limited study different cohorts of samples can elicit different gene panels with different significant levels. These in turn therefore impact which gene expression patterns are presented to the neural network for classifier development and sample characterisation. Stratification methodologies for gene selection are essential not only from the context of implementing multiple testing correction methodologies to reduce the risk of FDR but also that greater understanding is required how pattern recognition algorithms select the biomarkers used for model development and how robust these predictors for generalising new datasets. Understanding how biomarker selection can be influenced by systematic/biological factors including the composition of training, testing and validation datasets, may eventually lead to reduced FDR and enhance the rate at which diagnostic and prognostic tools finally deliver clinical utility for patients with HL.
Table 1 : Statistical overview of gene biomarkers identified as being differentially expressed between chemotherapy resistant and sensitiv Hodgkin's lymphoma patients between all 130 patients. The top 16 genes with adjusted p-values (q-values) to produce a FDR <5% are listed These genes were then used for downstream model development by ANN.
Probe ID Adjusted p-value t-statistic B-statistic Log FC Gene Gene Titie
p-value Symbol
229684_s_ at 0.0397 7.25E-07 5.2074648 5.35992 0.28146739 ZNF644 zinc finger protein 644
206131_at 0.041 2.03E-06 4.9739843 4.47186 0.21748507 CLPS colipase, pancreatic
235892_at 0.041 2.30E-06 4.9443194 4.3609 0.20662157 - EST tu05b03.x1
211753_s_ at 0.041 3.37E-06 4.8554657 4.03113 0.41671487 RLN1 relaxin 1
231065_at 0.041 4.33E-06 4.7968899 3.81589 0.24246424 PDE6D phosphodiesterase 6D, cGMP-specific, rod, delt
229080_at 0.041 4.72E-06 4.7764545 3.74121 0.17433947 EMID2 EMI domain containing 2
211936_at 0.041 5.46E-06 -4.7418324 3.61517 -0.49233209 HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
237807_at 0.041 7.43E-06 4.6683153 3.34961 0.2151131 SPATA12 spermatogenesis associated 12
214709_s_ at 0.041 7.50E-06 -4.6660489 3.34147 -0.31725235 KTN1 kinectin 1 (kinesin receptor)
206157_at 0.041 8.04E-06 -4.6493642 3.28161 -0.37434897 PTX3 pentraxin 3, long
396_f_at 0.041 8.25E-06 -4.6433778 3.26017 -0.33512048 EPOR erythropoietin receptor
242988_at 0.0491 1.09E-05 4.5764525 3.02177 0.17010006 DCST2 DC-STAMP domain containing 2
224816_at 0.0491 1.27E-05 4.5384171 2.88735 0.17845086 GET4 golgi to ER traffic protein 4 homolog (S.
cerevisiae)
211087_x_ at 0.0491 1.41 E-05 -4.5137578 2.80062 -0.25372443 MAPK14 mitogen-activated protein kinase 14
222883_at 0.0491 1.43E-05 -4.509901 2.78709 -0.35449136 C1orf163 chromosome 1 open reading frame 163
200915_x_ at 0.0491 1.44E-05 -4.5085246 2.78226 -0.27636888 KTN1 kinectin 1 (kinesin receptor)
5
Table 2: Percentage (%) accuracy for training, testing and validation performance for all 130 using the top 16 variables with FDR <5% a 5 predictors. Training samples n=39; Test samples n=13; Validation samples n=78. Models were developed from resistant and sensitive sample presented to the ANN in sequential order. The top 8 models are shown above from Run5 using variable sample seeding values.
Index Net name Training result Test result Validation result Training Error Hidden node Output node
(%) (%) algorithm function activation activation function function '; ;
1 MLP 16-2-2 100.0000 92.30769 88.46154 BFGS 9 SOS Tanh Identity
2 MLP 16-3-2 100.0000 92.30769 91.02564 BFGS 16 SOS Identity Identity
3 MLP 16-2-2 94.8718 84.61538 91.02564 BFGS 12 SOS Logistic Identity
4 MLP 16-3-2 94.8718 84.61538 91.02564 BFGS 14 SOS Exponential Exponential
5 MLP 16-2-2 94.8718 84.61538 91.02564 BFGS 13 SOS Exponential Identity
6 MLP 16-3-2 100.0000 84.61538 91.02564 BFGS 10 Entropy Tanh Softmax
7 MLP 16-2-2 97.4359 84.61538 91.02564 BFGS 6 Entropy Tanh Softmax
8 MLP 16-2-2 100.0000 84.61538 91.02564 BFGS 13 SOS Exponential Identity
10
Table 3a: The adjusted p-values are presented for the "original" 16 gene biomarkers. These genes were identified as being differentiall expressed between chemotherapy sensitive and resistant patients from all 130 patients. Significance testing results (following Benjamini and Hochberg multiple testing correction) are presented for genes identified as being differentially expressed between chemotherapy sensitive and resistant patients for Group 11 . The data suggests that all 16 genes have highly significant adjusted p-values.
Group114
Probe ID adj.P.Val P. Value t B logFC Gene, symbol Gene. title
211936_at 5.01 E-06 9.16E-11 -7.13947 13.90841 -7.22E-01 HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
229684_s_ at 1.54E-05 5.62E-10 6.775823 12.23857 3.71 E-01 ZNF644 zinc finger protein 644
206157_at 0.000105 9.64E-09 -6.18955 9.62154 -4.99E-01 PTX3 pentraxin 3, long
222883_at 0.000256 3.75E-08 -5.90067 8.37219 -5.02E-01 C1orf163 chromosome 1 open reading frame 163
214709_s_ at 0.00026 4.28E-08 -5.87223 8.25079 -4.23E-01 KTN1 kinectin 1 (kinesin receptor)
229080_at 0.000391 8.54E-08 5.722274 7.61572 2.29E-01 EMID2 EMI domain containing 2
211753_s_ at 0.000391 8.90E-08 5.713048 7.57693 5.24E-01 RLN1 relaxin 1
211087_x_ at 0.000391 1.19E-07 -5.64921 7.30942 -3.39E-01 MAP 14 mitogen-activated protein kinase 14
200915_x_ at 0.000391 1.38E-07 -5.61706 7.17528 -3.68E-01 KTN1 kinectin 1 (kinesin receptor)
237807_at 0.000391 1.43E-07 5.608707 7.14053 2.84E-01 SPATA12 spermatogenesis associated 12
206131_at 0.000393 1.51 E-07 5.597144 7.09244 2.72E-01 CLPS colipase, pancreatic
235892_at 0.00053 4.65E-07 5.345419 6.05915 2.45E-01 EST tu05b03.x1
231065_at 0.000617 5.86E-07 5.292855 5.84681 3.02E-01 PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
224816_at 0.00183 5.22E-06 4.781063 3.8464 2.12E-01 GET4 golgi to ER traffic protein 4 homolog (S.
cerevisiae)
396_f_at 0.002077 8.93E-06 -4.65061 3.35725 -3.43E-01 EPOR erythropoietin receptor
242988_at 0.003927 3.37E-05 4.317636 2.1504 1.84E-01 DCST2 DC-STAMP domain containing 2
Table 3b: The adjusted p-values are presented for the "original" 16 gene biomarkers. These genes were identified as being differentiall expressed between chemotherapy sensitive and resistant patients from all 130 patients. Significance testing results (following Benjamini an Hochberg multiple testing correction) are presented for genes identified as being differentially expressed between chemotherapy sensitive an resistant patients for Group 114. The data suggests that only one gene (C1orf163) has a significant adjusted p-value (in bold). All othe remaining genes from the "original" 16 are not statistically significant.
Group16
Probe ID adj.P.Val P. Value t B logFC Gene. symbol Gene. title
229684_s_at 0.759737 5.55E-01 -0.60297 -6.05105 -0.10867 ZNF644 zinc finger protein 644
206131_at 0.978879 9.51 E-01 -0.06233 -6.23258 -0.00638 CLPS colipase, pancreatic
235892_at 0.786639 5.96E-01 -0.54066 -6.08669 -0.0576 EST tu05b03.x1
211753_s_at 0.379208 1.23E-01 -1.62719 -4.98525 -0.32003 RLN1 relaxin 1
231065_at 0.554848 2.87E-01 -1.10092 -5.63842 -0.09878 PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
229080_at 0.612017 3.56E-01 -0.95017 -5.78634 -0.08444 EMID2 EMI domain containing 2
211936_at 0.147942 1.32E-02 2.778025 -3.03292 0.782984 HSPA5 heat shock 70kDa protein 5 (glucose- regulated protein, 78kDa)
237807_at 0.316576 8.23E-02 -1.85108 -4.65214 -0.16915 SPATA12 spermatogenesis associated 12
214709_s_at 0.522681 2.52E-01 1.187912 -5.54458 0.214002 KTN1 kinectin 1 (kinesin receptor)
206157_at 0.24202 4.38E-02 2.183847 -4.10878 0.486089 PTX3 pentraxin 3, long
396_f_at 0.752169 5.44E-01 -0.61981 -6.04078 -0.1665 EPOR erythropoietin receptor
242988_at 0.728663 5.08E-01 0.677524 -6.00355 0.052962 DCST2 DC-STAMP domain containing 2
224816_at 0.814203 6.40E-01 -0.47592 -6.11975 -0.0406 GET4 golgi to ER traffic protein 4 homolog (S.
cerevisiae)
211087_x_at 0.489059 2.18E-01 1.280673 -5.43801 0.18543 MAPK14 mitogen-activated protein kinase 14
222883_at 0.034263 4.65E-04 4.356823 0.080885 0.466637 C1orf163 chromosome 1 open reading frame 163
200915_x_at 0.498848 2.28E-01 1.253598 -5.46979 0.197557 KTN1 kinectin 1 (kinesin receptor)
Table 4: Predictive accuracy (%) for Group 114 samples for training, testing and validation datasets using the 16 variables identified fro Group 130 as predictors (adjusted p-value with FDR≤0.05). Training samples n=35; Test samples n=11 ; Validation samples n=68. Models wer developed using resistant and sensitive samples presented to the ANN in randomised sample order. The top 8 models are shown above fro Run5 using variable sample seeding values. Models 2, 3 and 4 show 100% accuracy for all sample datasets (training, testing and validation).
Index Wei. name Training result Test result Validation result (%) Training Error Hidden node Output nod
(%) (%) algorithm function activation function activation function
1 MLP 16-3-2 94.2857143 100 97.0588235 BFGS 3 Entropy Logistic Softmax
2 MLP 16-2-2 100 100 100 BFGS 13 SOS Tanh Tanh
3 MLP 16-2-2 100 100 100 BFGS 5 SOS Tanh Tanh
4 MLP 16-2-2 100 100 100 BFGS 12 SOS Logistic Exponentia
5 MLP 16-3-2 97.1428571 100 100 BFGS 5 SOS Identity Tanh
6 MLP 16-2-2 97.1428571 100 100 BFGS 5 SOS Identity Tanh
7 MLP 16-2-2 94.2857143 100 100 BFGS 6 SOS Logistic Identity
8 MLP 16-2-2 94.2857143 100 100 BFGS 4 SOS Tanh Identity
Table 5 (continued overleaf): Statistical overview of gene biomarkers identified as differentially expressed between chemotherapy resistant and sensitive Hodgkin's lymphoma patients for Group 16. The top 50 gene biomarkers as measured by their adjusted p-values to produce a FDR <5% are listed
Probe ID Adj P- P- Value f B logFC Gene
Value Symbol
202877 s at 0.000133 2.43E-09 11.6518204 10.766889 1.78435714 CD93
230025 at 0.000167 6.10E-09 10.9400388 10.044983 1.41239683 GJD3
205991 s at 0.000747 4.10E-08 9.5723192 8.490335 1.75162063 PRRX1
210510 s at 0.001086 7.94E-08 9.1284516 7.933817 1.2726 NRP1
226632 at 0.001243 1.18E-07 8.8671362 7.593381 1.05169206 CYGB
205582 s at 0.001243 1.36E-07 8.7763016 7.472765 1.91094762 GGT5
213290 at 0.001363 2.10E-07 8.5032838 7.103014 2.068111 1 1 COL6A2
208767 s at 0.001363 2.11 E-07 8.4975419 7.09512 1.66799048 LAPTM4B
209094 at 0.001363 2.24E-07 8.4604733 7.044041 1.60410476 DDAH1
222451 s at 0.001467 2.68E-07 8.348692 6.888772 1.16314286 ZDHHC9
224861 at 0.001592 3.20E-07 8.2387431 6.73422 1.35432063 GNAQ
212298 at 0.001888 4.14E-07 8.0811009 6.509432 2.3672 NRP1
207277 at 0.00211 5.46E-07 7.9146444 6.267946 3.03822222 CD209
212463 at 0.00211 5.59E-07 7.9003253 6.246973 1.44157143 CD59
208703 s at 0.00211 5.79E-07 7.8789024 6.215535 1.47861905 APLP2
225262 at 0.002128 6.44E-07 7.8154248 6.121965 1.80221905 FOSL2
217890 s at 0.002128 7.36E-07 7.7361413 6.004214 1.59586984 PARVA
1558214 s at 0.002128 7.64E-07 7.7134578 5.970343 1.13446349 CTNNA1
218486 at 0.002128 7.75E-07 7.7049998 5.957693 1.40943492 KLF11
202436 s at 0.002128 7.97E-07 7.6889253 5.933621 1.78844286 CYP1 B1
212091 s at 0.002128 8.25E-07 7.6684963 5.902969 2.16407937 COL6A1
219872 at 0.002128 8.85E-07 7.6271413 5.840719 1.17368254 FAM198B
211852 s at 0.002128 9.30E-07 7.5980129 5.796711 1.27689841 ATRN
201551 s at 0.002128 9.34E-07 7.5951136 5.792324 1.61768413 LAMP1
202368 s at 0.002358 1.08E-06 7.51 12786 5.664878 1.17144603 TRAM2
224895 at 0.002492 1.19E-06 7.4561617 5.580482 1.62590635 YAP1
38918 at 0.002807 1.46E-06 7.3358616 5.394598 0.61377619 SOX13
232053 X at 0.002807 1.46E-06 7.3356322 5.394242 1.16409206 RHBDD2
212067 s at 0.002807 1.49E-06 7.3245573 5.377013 2.11216349 C1 R
222446 s at 0.003058 1.68E-06 7.2559825 5.269895 1.41917143 BACE2
37005 at 0.003308 1.92E-06 7.178293 5.14763 1.66252063 NBL1
209297 at 0.003308 2.00E-06 7.1562623 5.1 12782 1.33423333 ITSN1
223253 at 0.003308 2.04E-06 7.145398 5.095569 1.86142381 EPDR1
220240 s at 0.003308 2.06E-06 7.1400526 5.087092 0.74083968 TMC03
204163 at 0.003443 2.24E-06 7.0926896 5.011787 2.15344921 EMILIN1
236297 at 0.003443 2.27E-06 7.0851316 4.999737 1.24897619
1554679 s at 0.003739 2.53E-06 7.0232131 4.900668 1.48330159 LAPTM4B
201559 s at 0.003934 2.82E-06 6.9622711 4.802559 1.53854286 CLIC4
235072 s at 0.003934 2.84E-06 6.958498 4.796465 1.24865397
215073 s at 0.003934 2.88E-06 6.951 1579 4.784604 1.91315556 NR2F2
1555326 a at 0.004066 3.05E-06 6.9189606 4.73247 1.19431587 ADAM9
Probe ID A dj P- P-Value f β logFC Gene
Value Symbol
202435 s at 0.004163 3.23E-06 6.8875259 4.68141 1.69770476 CYP1 B1
235438 at 0.004163 3.27E-06 6.8793187 4.668053 1.33092698
219065. _s_ at 0.004556 3.67E-06 -6.8166331 4.565671 MEM01
0.70693016
209228 X at 0.004638 3.87E-06 6.7873037 4.517551 0.80019683 TUSC3
218880 at 0.004638 4.07E-06 6.7592444 4.471385 1.53982381 F0SL2
201042 at 0.004638 4.22E-06 6.739528 4.438869 2.97900794 TGM2
201874 at 0.004638 4.30E-06 6.7288651 4.421258 1.14039206 MPZL1
201621 at 0.004638 4.37E-06 6.7194203 4.405643 1.36420317 NBL1
Table 6: Percentage (%) accuracy for training, testing and validation performance for Group 16 outlier samples using the top 4 gene biomarker with FDR <5% as predictors (refer to Table 5). Training samples 30% (n=5); Test samples 20% (n=3); Validation samples 50% (n=8). Model were developed from resistant and sensitive samples presented to the ANN in randomised sample order. The top 8 models are shown abov from Run1 using variable sample and constant network seeding values. The data for Models 1-8 is presented indicating 100% classifyin accuracy for training, testing and validation sample sets. Models 1-100 models had 100% correct prediction for all samples in training, testin and validation datasets.
Index Net name Training pert. Test pert. Validation per Training Error function Hidden Output
algorithm activation activation
1 MLP 4-2-2 100.0000 100.0000 100.0000 BFGS 0 SOS Exponential Logistic
2 MLP 4-2-2 100.0000 100.0000 100.0000 BFGS 0 Entropy Exponential Softmax
3 MLP 4-2-2 100.0000 100.0000 100.0000 BFGS 0 SOS Identity Exponential
4 MLP 4-2-2 100.0000 100.0000 100.0000 BFGS 4 SOS Exponential Identity
5 MLP 4-2-2 100.0000 100.0000 100.0000 BFGS 0 SOS Logistic Tanh
6 MLP 4-2-2 100.0000 100.0000 100.0000 BFGS 4 SOS Exponential Logistic
7 MLP 4-3-2 100.0000 100.0000 100.0000 BFGS 4 Entropy Exponential Softmax
8 MLP 4-2-2 100.0000 100.0000 100.0000 BFGS 5 SOS Logistic Logistic
Conclusions
Rationalising treatment options for patients with HL using molecular based prognosticators has the potential to translate into significantly improved outcomes for these patients. Microarray profiling is a fundamental "omics" technology being intensively exploited to identify expression patterns associated with pathologies of clinical interest and their clinical management e.g. disease progression; recurrence; response to therapeutic intervention. It is in relation to the last example that prognostication could strongly impact the treatment of HL patients by directing the most appropriate therapy towards individuals whom are most likely to benefit. Such molecular tests could also be applied in triaging patients that have a high probability of being refractory to a given regimen enabling alternate treatments to be recommended. The basis of prognostic test development will remain in the identification of biomarkers whose expression pattern is specific to the clinical indication under investigation and robust enough to enable the development of classifiers that can be independently validated. Such a co-ordinated strategy will enable test parameters including limitations and caveats) to be appropriately determined and strengthen the prognosticators clinical utility for predicting chemo- response. This study utilised DNA microarray expression series GSE17920 obtained from the NCBI Gene Expression Omnibus archive. This dataset was normalised (to account for both intra, inter and batch to batch variation) and was used to explore the development of chemotherapy response binary classifiers. 16 genes (FDR≤ 5%) were identified as being differentially expressed between the chemo-sensitive (n=92) and chemo-resistant (n=38) HL patients. Multi-layer perceptron ANN architectures were implemented and predictive performance of the individual models was assessed using both test and validation datasets (comprising 70% of total samples). Over 600,000 models were constructed and one classifier in particular assigned 100%, 92% and 91% of training, testing and validation samples to their correct classes (chemo-sensitive/chemo-resistance) respectively and produced an AUC of 0.926 for the ROC plot.
From this initial analysis outliers were identified that performed poorly with respect to prediction and so attention was directed towards the isolation of these samples from the main cohort such that two groups were formed: Group 16 (outliers) and Group 114 (non- outliers). Re-analysis by GEOquery and LIMMA for differentially expressed genes
(between chemo-sensitive and chemo-resistant patients) led to the identification of 1 138 and 5344 probe sets for Group 16 and Group 1 14 respectively (FDR≤ 5%). Interestingly only one out of the original 16 genes that were identified as being significantly different for all 130 samples remained significant for Group 16 compared to Group 114 where all 16 genes maintained significance (FDR < 5%). While computational systematic effects cannot entirely be ruled out, it is plausible that the outliers may indeed represent a distinct biological population based upon gene expression profiles. For the outliers 22% of the first 50 genes explored have been previously associated with clinical outcome and/or chemotherapy treatment and thus may lend support to the contention that the poor predictive capability initially witnessed for this group could be attributed to an alternate expression pattern. It is unclear whether this difference in expression pattern between the two patient classes, is attributed to alternate effects e.g. sample storage, preparation and/or processing. Retraining of each group in isolation elicited models with 100% classification accuracy for all samples present within the training, testing and validation cohorts.
In summary therefore ANN provide an extremely useful in-silico modelling tool with strong predictive accuracy for classifying chemo-sensitive and chemo-resistant HL patient expression profiles taken from pre-treatment core biopsies. Random combinations of training, testing and validation datasets and predictive modelling have assisted the identification of outliers which might suggest the presence of biological variance in expression pattern compared to pattern exhibited from all 130 samples. When the outliers are removed from the remaining samples, both groups have increased number of differentially expressed genes (FDR≤ 5%). There is the suggestion therefore that outliers may not only have a negative impact upon the predictive performance of ANN based classifiers but that they may also impact the significance of genes that are initially presented for further interrogation by tools such as LIMMA. This would consequently have a downstream impact as to which biomarkers are given due consideration for biological validation studies.
Methods
Gene Expression Omnibus microarray series GSE17920 GSE17920 data series contained DNA microarray expression data obtained from 130 pre-treatment core biopsies from classic Hodgkin's Lymphoma patients in which 38 patients were clinically resistant and 92 patients were noted to be sensitive to their chemotherapy treatment. DNA microarray analysis was conducted using Affymetrix GeneChip Human Genome U133 Plus 2.0 array. In brief the data were normalized and summaried using the rma function in the Affymetrix package. Batch-normalization was carried out using ComBat.
GEQ2R and gene selection GE02R is a web based interface allowing users to call GEOquery in order to parse microarray expression data into structures suitable for statistical interrogation by LIMMA. Both software packages (written in R) are available from the Bioconductor project (http://www.bioconductor.org/). Benjamini and Hochberg multiple testing correction analysis was applied to raw p-values (q-values) and genes were selected for ANN model development that had a q-value (false discovery rate) of≤ 0.05.
ANN model development
All modelling was carried out using Statistica Data Mining software (Statsoft Corporation USA). Supervised learning algorithms were developed using a MLP back propagation ANN and automated search parameters. A classification algorithm was selected and the categorical output was chemotherapeutic response.
Automated ANN modelling was established to both construct and test architecture robustness of the resultant ANN using random cohorts of samples selected by number seeds. Sample sizes for training, testing and validation were set at 30%, 10% and 60% for Group 130 and Group 114. For Group 16 training, testing and validation samples were set at 30%, 20% and 50% respectively. Architectures were built upon the Broyden- F!etcher-Go!dfarb-Shanno (BFGS) optimisation algorithm. Activation functions which were used to propagate the input values into a classification result were chosen at
random from a number of transformative formulae for both the hidden and output nodes. These included: a) logistic; b) Tanh; c) Softmax; d) Identity; e) exponential. Sum of squares and entropy were used to measure classification error between actual and network prediction. Error values were back propagated allowing alteration of the weighted links between input/hidden and hidden/output layers. Model development had the flexibility to use either two or three hidden nodes allowing parsimonious algorithms with sufficient power to be produced.
Seeding values were altered to enable different combinations of training, testing and validation while keeping network seed constant. Variable network seeding values were used to examine the effect of varying network weights while keeping training, testing and validation sample sets constant.
20,000 models were run per analysis and the top 100 models with the highest predictive accuracy for training, testing and validation datasets were retained for statistical analysis. 10 runs were conducted for each parameter analysed. Two main variable settings were explored: a) variable sample seed with constant network seed weighting; b) variable network weighting with constant sample seed to ensure the same samples comprised the training, testing and validation datasets. This methodology was repeated for both the "randomised" and "non-randomised" sample order used for presentation to the ANN for model development. This study explored the development of over 1 million computational models.
Predictive accuracy as exemplified by heatmap signatures were produced using Microsoft Excel. Confidence intervals were calculated using a two-tailed t-distribution at the a < 0.05 level.
EXAMPLE B
Exemplary neural network coding developed using Group 130 (full dataset) and the sixteen gene biomarkers listed in Table 1 (see Example A)
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Exemplary neural network coding developed using Group 16 outliers and the top four gene biomarkers listed in Table 6 (see Example A)
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lowValue="1.610900'7><MiningField name="224816_at" highValue="2.959900"
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Claims
1. An in vitro method for determining the responsiveness of an individual with Hodgkin's lymphoma to chemotherapeutic drug treatment, the method comprising the steps of: a) providing a protein or mRNA sample an individual to be tested; b) determining the presence and/or amount in the sample of at least two proteins selected from the group identified in Table A, and/or of mRNA encoding the same wherein one or more of the at least two proteins selected from the group defined in Table A is not identified in Table B and wherein the presence and/or amount in the sample of the proteins selected from the group defined in Table A, or of the mRNA encoding the same, is indicative of the responsiveness of the individual with Hodgkin's lymphoma to chemotherapeutic drug treatment.
2. A method according to Claim 1 wherein the sample in step (a) is a lymph node tumour biopsy sample.
3. A method according to Claim 1 or 2 wherein step (b) comprises measuring the presence and/or amount in the sample of zinc finger protein 644 (ZNF644) and/or heat shock 70kDa protein 5 (HSPA5), and/or mRNA encoding the same.
4. A method according to any one of the preceding claims wherein step (b) comprises measuring the presence and/or amount in the sample of at least three proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table A, and/or mRNA encoding the same.
A method according to Claim 4 wherein step (b) comprises measuring the presence and/or amount in the sample of at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table A, and/or mRNA encoding the same.
6. A method according to any one of the preceding claims wherein the proteins, and/or mRNA encoding the same, measured in step (b) are selected from one of the following groups defined in Table A:
(a) Biomarker nos. 1 to 10;
(b) Biomarker nos. 1 to 20;
(c) Biomarker nos. 1 to 30;
(d) Biomarker nos. 1 to 40;
(e) Biomarker nos. 1 to 50;
(f) Biomarker nos. 1 to 100;
(g) Biomarker nos. 1 to 200;
(h) Biomarker nos. 1 to 500;
(i) Biomarker nos. 1 to 1000;
C) Biomarker nos. 1 to 2000;
(k) Biomarker nos. 1 to 3000; or
(I) Biomarker nos. 1 to 4000.
7. A method according to any one of the preceding claims wherein none of the at least two proteins selected from the group defined in Table A are identified in Table B.
8. A method according to any one of the preceding claims wherein step (b) comprises measuring the presence and/or amount in the sample of at least one protein, and/or mRNA encoding the same, selected from the group consisting of:
(a) Zinc finger protein 644 (ZNF644) ;
(b) Colipase, pancreatic (CLPS) ;
(c) EST tu05b03.x1 ;
(d) relaxin 1 (RLN1);
(e) phosphodiesterase 6D, cGMP-specific, rod, delta (PDE6D);
(f) EMI domain containing 2 (EMID2);
(g) heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa; HSPA5))
(h) spermatogenesis associated 12 (SPATA12);
0) kinectin 1 (kinesin receptor; KTN1 );
G) pentraxin 3, long (PTX3);
(k) erythropoietin receptor (EPOR);
(1) DC-STAMP domain containing 2 (DCST2);
(m) golgi to ER traffic protein 4 homolog (S. cerevisiae; GET4);
(n) mitogen-activated protein kinase 14 (MAPK14); and
(o) chromosome 1 open reading frame 163 (C1 orf163).
9. A method according to Claim 8 wherein step (b) comprises measuring the presence and/or amount in the sample of all of the following proteins, and/or mRNA encoding the same:
(a) Zinc finger protein 644 (ZNF644) ;
(b) Colipase, pancreatic (CLPS) ;
(c) EST tu05b03.x1 ;
(d) relaxin 1 (RLN1);
(e) phosphodiesterase 6D, cGMP-specific, rod, delta (PDE6D);
(f) EMI domain containing 2 (EMID2);
(g) heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa; HSPA5));
(h) spermatogenesis associated 12 (SPATA12);
(i) kinectin 1 (kinesin receptor; KTN1);
0) pentraxin 3, long (PTX3);
(k) erythropoietin receptor (EPOR);
(I) DC-STAMP domain containing 2 (DCST2);
(m) golgi to ER traffic protein 4 homolog (S. cerevisiae; GET4);
(n) mitogen-activated protein kinase 14 (MAP 14); and
(o) chromosome 1 open reading frame 163 (C1 orf163).
A method according to any one of the preceding claims wherein step (b) comprises measuring the presence and/or amount in the sample of mRNA encoding the proteins selected from the group identified in Table A.
11. A method according to Claim 10 wherein measuring the presence and/or amount in the sample of the mRNA is performed using binding agents capable of binding to the said mRNA.
12. A method according to Claim 11 wherein the binding agents are oligonucleotides.
13. A method according to any one of the preceding claims wherein step (b) comprises measuring the presence and/or amount in the sample of the proteins selected from the group identified in Table A.
14. A method according to Claim 13 wherein measuring the presence and/or amount in the sample of the proteins is performed using binding agents capable of binding to said proteins.
15. A method according to Claim 14 wherein the binding agents comprise or consist of an antibody or an antigen-binding fragment thereof.
16. A method according to Claim 15 wherein the antibody or antigen-binding fragment is selected from the group consisting of intact antibodies, Fv fragments
(e.g. single chain Fv and disulphide-bonded Fv), Fab-like fragments (e.g. Fab fragments, Fab' fragments and F(ab)2 fragments), single variable domains (e.g. VH and VL domains) and domain antibodies (dAbs, including single and dual formats [i.e. dAb-linker-dAb]).
17. A method according to Claim 16 wherein the antibody or antigen-binding fragment is a single chain Fv (scFv).
18. A method according to Claim 14 wherein the binding agent comprises or consists of an antibody-like binding agent, for example an affibody or aptamer.
19. A method according to any one of the preceding claims wherein the proteins in the sample are labelled with a detectable moiety prior to performing step (b).
20. A method according to Claim 19 wherein the detectable moiety is selected from the group consisting of: a fluorescent moiety; a luminescent moiety; a chemiluminescent moiety; a radioactive moiety; an enzymatic moiety.
21. A method according to any one of the preceding claims wherein measuring the presence and/or amount of the proteins, or mRNA encoding the same, in the sample is performed using a gene expression profiling array.
22. A method according to Claim 21 wherein the array is a surface-based array.
23. A method according to Claim 21 wherein the array is a bead-based array.
24. A method according to any one of Claims 21 to 23 wherein the array is selected from the group consisting of: macroarray; microarray; nanoarray.
25. A method according to any one of the preceding claims further comprising step (c) of comparing the presence and/or amount of the proteins, or mRNA encoding the same, with one or more reference values for said proteins or mRNA.
26. A method according to Claim 25 wherein the reference values correspond to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals selected from the group consisting of healthy individuals, individuals diagnosed with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment and individuals diagnosed with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment.
27. A method according to Claim 25 or 26 wherein the amount of the proteins, or mRNA encoding the same, obtained in step (b) and the reference values for said proteins or mRNA are normalised prior to being compared.
28. A method according to any one of Claims 25 to 27 wherein step (c) comprises the use of a predictive model.
29. A method according to any one of Claims 25 to 28 wherein step (c) comprises use of a computer-implemented adaptive learning algorithm.
30. A method according to Claim 29 wherein the adaptive learning algorithm is an artificial neural network.
31. A method according to Claim 30 wherein the artificial neural network is a multilayer perceptron.
32. A method according to any one of Claims 28 to 31 wherein the predictive model has an accuracy of at least 90% for classification.
33. A method according to Claim 32 wherein the predictive model has an accuracy of at least 95% for classification.
34. A method according to Claim 33 wherein the predictive model has an accuracy of at least 99% for classification.
35. A method according to any one of Claims 26 to 34 wherein:
(a) an elevation in the amount of one or more of the following proteins (or mRNA encoding the same) relative to reference values corresponding to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment
HSPA5, PTX3, C1 orf163, KTN1 , MAP 14 and/or EPOR and/or
(b) a decrease in the amount of one or more of the following proteins (or mRNA encoding the same) relative to reference values corresponding to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment
ZNF644, EMID2, RLN1 , SPATA12, CLPS, EST ti.05b03.x1 , PDE6D, GET 4 and/or DCST2 is indicative of the individual with Hodgkin's lymphoma being responsive to chemotherapeutic drug treatment.
36. A method according to any one of Claims 26 to 34 wherein:
(a) an elevation in the amount of one or more of the following proteins (or mRNA encoding the same) relative to reference values corresponding to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment
ZNF644, EMID2, RLN1 , SPATA12, CLPS, EST tu05b03.x1 , PDE6D, GET 4 and/or DCST2 and/or
(b) a decrease in the amount of one or more of the following proteins (or mRNA encoding the same) relative to reference values corresponding to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment
HSPA5, PTX3, C1 orf163, KTN1 , MAPK14 and/or EPOR is indicative of the individual with Hodgkin's lymphoma being resistant to chemotherapeutic drug treatment.
37. A method according to any one of Claims 26 to 36 wherein step (c) comprises identifying the individual as exhibiting atypical gene expression.
A method according to Claim 37 further comprising step (d) of determining the presence and/or amount in the sample of at least two proteins selected from the group identified in Table D, and/or of mRNA encoding the same.
A method according to Claim 38 wherein step (d) comprises measuring the presence and/or amount in the sample of at least three proteins selected from the group identified in Table D, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table D, and/or mRNA encoding the same.
A method according to Claim 39 wherein step (d) comprises measuring the presence and/or amount in the sample of at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table D, and/or mRNA encoding the same.
A method according to any one of Claims 38 to 40 wherein the proteins, and/or mRNA encoding the same, measured in step (d) are selected from one of the following groups defined in Table D:
(a) Biomarker nos. 1 to 10;
(b) Biomarker nos. 1 to 20;
(c) Biomarker nos. 1 to 30;
(d) Biomarker nos. 1 to 40;
(e) Biomarker nos. 1 to 50;
(f) Biomarker nos. 1 to 100;
(g) Biomarker nos. 1 to 200;
(h) Biomarker nos. 1 to 500; or
(i) Biomarker nos. 1 to 1000.
A method according to any one of Claims 38 to 41 wherein step (d) comprises measuring the presence and/or amount in the sample of at least one protein, and/or mRNA encoding the same, selected from the group consisting of
(a) CD93 molecule (CD93);
(b) Gap junction protein, delta 3, 31.9 kDa (GJD3);
(c) Paired related homeobox 1 (PRRX1);
(d) Neuropilin 1 (NRP1);
(e) Cytoglobin (CYGB);
(f) Gamma-glutamyl transferase 5 (GGT5);
(g) Collagen, type VI, alpha 2 (COL6A2);
(h) Lysosomal protein transmembrane 4 beta (LAPTM4B);
(0 Dimethylarginine dimethylaminohydrolase 1 (DDAH1 ); and
(j) Zinc finger, DHHC-type containing 9 (ZDHHC9).
43. A method according to Claim 42 wherein step (d) comprises measuring the presence and/or amount in the sample of all of the following proteins, and/or mRNA encoding the same:
(a) CD93 molecule (CD93);
(b) Gap junction protein, delta 3, 31.9 kDa (GJD3);
(c) Paired related homeobox 1 (PRRX1); and
(d) Neuropilin 1 (NRP1).
44. A method according to any one of Claims 38 to 43 further comprising step (e) of comparing the presence and/or amount of the proteins, or mRNA encoding the same, with one or more reference values for said proteins or mRNA.
45. A method according to Claim 44 wherein the reference values correspond to the presence and/or amount of said proteins or mRNA in lymph node tissue from one or more individuals selected from a group consisting of healthy individuals, individuals diagnosed with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment and individuals diagnosed with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment.
46. A method according to Claim 44 or 45 wherein the amount of the proteins, or mRNA encoding the same, obtained in step (e) and the reference values for said proteins or mRNA are normalised prior to being compared.
47. A method according to any one of the preceding claims further comprising the step of determining the medication history of the individual.
48. A method according to Claim 47 wherein determining the medication history of the individual comprises determining whether the patient has taken any HIV drug therapies prior to providing the sample.
49. A method for treating an individual with Hodgkin's lymphoma comprising:
(a) identifying an individual with Hodgkin's lymphoma who is responsive to chemotherapeutic drug treatment using a method according to any one of Claims 1 to 48; and
(b) administering a chemotherapeutic drug to the individual identified in step (a).
50. A method for treating an individual with Hodgkin's lymphoma comprising:
(a) identifying an individual with Hodgkin's lymphoma who is resistant to chemotherapeutic drug treatment using a method according to any one of Claims 1 to 48; and
(b) administering a therapeutic agent other than a chemotherapeutic drug to the individual identified in step (a).
51. A method according to Claim 50 wherein the therapeutic agent other than a chemotherapeutic drug is radiation therapy.
52. A method for treating an individual with Hodgkin's lymphoma comprising:
(a) determining the responsiveness of an individual with Hodgkin's lymphoma to chemotherapeutic drug treatment using a method according to any one of Claims 1 to 48;
(b) selecting an effective therapeutic agent for administration to the individual based on the responsiveness of the patient to chemotherapeutic drug treatment; and
(c) administering said effective therapeutic agent identified in step (b) to the individual.
An array for use in a method according any one of Claims 1 to 48, the array comprising binding agents for two or more of the proteins identified in Table A and/or D, or mRNA encoding the same.
An array according to Claim 53 wherein the array comprises binding agents for fewer then 1000 different proteins identified in Table A and/or D, or mRNA coding the same, for example fewer than 500, 400, 300, 200, 100, 50, 25, or 20 different proteins, or mRNA coding the same
55. An array according to Claim 53 or 54 wherein the array comprises binding agents for all of the proteins identified in Table C, or mRNA encoding the same. 56. An array according to Claim 55 wherein the array comprises binding agents for all of the proteins identified in Table A, or mRNA encoding the same.
57. An array according to any one of Claims 53 to 56 wherein the array comprises binding agents for all of the proteins identified in Table D, or mRNA encoding the same.
58. An array according to any one of Claims 53 to 57 wherein the array comprises binding agents for ail of the proteins identified in Tables A and D. 59. An array according to any one of Claims 53 to 57 wherein the array comprises binding agents for mRNA encoding all of the proteins in Tables A and D.
60. An array according to any one of Claims 53 to 59 wherein the binding agents are immobilised.
An array according to any one of Claims 53 to 60 wherein the array is a surface- based array or bead-based array.
An array according to any one of Claims 53 to 61 wherein the array is suitable for use with high-throughput screening methods of gene profiling.
A kit for performing a method according to any one of Claims 1 to 48 comprising:
(a) an array according to any one of Claims 53 to 62; and
(b) instructions for performing a method according to any one of Claims 1 to 48.
A kit according to Claim 63 further comprising one or more reagents for use in a method according to any one of Claims 1 to 48.
A kit according to Claim 63 or 64 further comprising a positive control sample and/or a negative control sample.
A computer-implemented method for classifying a sample from an individual with Hodgkin's lymphoma, comprising:
(a) providing a dataset associated with the sample, wherein said dataset comprises quantitative data for at least two proteins, and/or mRNA encoding the same, selected from the group defined in Table A;
(b) inputting said dataset into an analytical process on a computer that compares said dataset against one or more reference datasets; and
(c) classifying said sample according to the output of said analytical process wherein one or more of the at least two proteins selected from the group defined in Table A is not identified in Table B. and wherein in step (c) the sample is classified as from an individual with Hodgkin's lymphoma who is responsive to chemotherapeutic drug treatment or
from an individual with Hodgkin's lymphoma who is resistant to chemotherapeutic drug treatment.
A computer-implemented method according to Claim 66 wherein the dataset in step (a) comprises quantitative data for zinc finger protein 644 (ZNF644) and/or heat shock 70kDa protein 5 (HSPA5), and/or mRNA encoding the same.
A computer-implemented method according to Claim 66 or 67 wherein the dataset in step (a) comprises quantitative data for at least three proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table A, and/or mRNA encoding the same.
A computer-implemented method according to Claim 68 wherein the dataset in step (a) comprises quantitative data for at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table A, and/or mRNA encoding the same.
A computer-implemented method according to any one of Claims 66 to 69 wherein the proteins, and/or mRNA encoding the same, for which quantitative data are provided in step (a) are selected from one of the following groups defined in Table A:
(a) Biomarker nos. 1 to 10;
(b) Biomarker nos. 1 to 20;
(c) Biomarker nos. 1 to 30;
(d) Biomarker nos. 1 to 40;
(e) Biomarker nos. 1 to 50;
(f) Biomarker nos. 1 to 100;
(g) Biomarker nos. 1 to 200;
(h) Biomarker nos. 1 to 500;
(i) Biomarker nos. 1 to 1000;
G) Biomarker nos. 1 to 2000;
(k) Biomarker nos. 1 to 3000; or
(I) Biomarker nos. 1 to 4000.
A computer-implemented method according to any one of Claims 66 to 70 wherein none of the at least two proteins selected from the group identified in Table A are identified in Table B.
A computer-implemented method according to Claim 66 or 71 wherein the dataset in step (a) comprises quantitative data for at least one protein, and/or mRNA encoding the same, selected from the group consisting of:
(a) Zinc finger protein 644 (ZNF644) ;
(b) Colipase, pancreatic (CLPS) ;
(c) EST tu05b03.x1 ;
(d) relaxin 1 (RLN1 );
(e) phosphodiesterase 6D, cGMP-specific, rod, delta (PDE6D);
(f) EMI domain containing 2 (E ID2);
(g) heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa; HSPA5));
(h) spermatogenesis associated 12 (SPATA12);
(i) kinectin 1 (kinesin receptor; KTN1);
G) pentraxin 3, long (PTX3);
(k) erythropoietin receptor (EPOR);
(I) DC-STAMP domain containing 2 (DCST2);
(m) golgi to ER traffic protein 4 homolog (S. cerevisiae; GET4);
(n) mitogen-activated protein kinase 14 (MAPK14); and
(o) chromosome 1 open reading frame 163 (C1orf163).
A computer-implemented method according to Claim 66 or 72 wherein the dataset in step (a) comprises quantitative data for all of the following proteins, and/or mRNA encoding the same:
(a) Zinc finger protein 644 (ZNF644) ;
(b) Colipase, pancreatic (CLPS) ;
(c) EST tu05b03.x1 ;
(d) relaxin 1 (RLN1 );
(e) phosphodiesterase 6D, cGMP-specific, rod, delta (PDE6D);
(f) EMI domain containing 2 (EMID2);
(g) heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa; HSPA5));
(h) spermatogenesis associated 12 (SPATA12);
(i) kinectin 1 (kinesin receptor; KTN1);
(j) pentraxin 3, long (PTX3);
(k) erythropoietin receptor (EPOR);
(1) DC-STAMP domain containing 2 (DCST2);
(m) golgi to ER traffic protein 4 homolog (S. cerevisiae; GET4);
(n) mitogen-activated protein kinase 14 (MAPK14); and
(o) chromosome 1 open reading frame 163 (C1 orf163).
74. A computer-implemented method according to any one of Claims 66 to 73 wherein the dataset in step (a) comprises quantitative data for at least two proteins selected from the group identified in Table D, and/or of mRNA encoding the same.
75. A computer-implemented method according to Claim 74 wherein the dataset in step (a) comprises quantitative data for at least three proteins selected from the group identified in Table D, and/or mRNA encoding the same, for example at least four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, fifteen or more proteins selected from the group identified in Table D, and/or mRNA encoding the same.
76. A computer-implemented method according to Claim 75 wherein the dataset in step (a) comprises quantitative data for at least 20 proteins selected from the group identified in Table A, and/or mRNA encoding the same, for example at least 30, 40, 50, 100, 200, 500, 1000, or more proteins selected from the group identified in Table D, and/or mRNA encoding the same.
77. The computer-implemented according to any one of Claims 74 to 76 wherein the proteins, and/or mRNA encoding the same, for which quantitative data are provided in step (a) are selected from one of the following groups defined in Table D:
(a) Biomarker nos. 1 to 10
(b) Biomarker nos. 1 to 20
(c) Biomarker nos. 1 to 30
(d) Biomarker nos. 1 to 40
(e) Biomarker nos. 1 to 50
(f) Biomarker nos. 1 to 100;
(g) Biomarker nos. 1 to 200;
(h) Biomarker nos. 1 to 500; or
(i) Biomarker nos. 1 to 1000.
A computer-implemented method according to Claim 74 or 77 wherein the dataset in step (a) comprises quantitative data for at least one protein, and/or mRNA encoding the same, selected from the group consisting of:
(a) CD93 molecule (CD93);
(b) Gap junction protein, delta 3, 31.9 kDa (GJD3);
(c) Paired related homeobox 1 (PRRX1);
(d) Neuropilin 1 (NRP1);
(e) Cytoglobin (CYGB);
(f) Gamma-glutamyl transferase 5 (GGT5);
(g) Collagen, type VI, alpha 2 (COL6A2);
(h) Lysosomal protein transmembrane 4 beta (LAPTM4B);
(i) Dimethylarginine dimethylaminohydrolase 1 (DDAH1); and
(j) Zinc finger, DHHC-type containing 9 (ZDHHC9).
A computer-implemented method according to Claim 78 wherein the dataset in step (a) comprises quantitative data for all of the following proteins, and/or mRNA encoding the same:
(a) CD93 molecule (CD93);
(b) Gap junction protein, delta 3, 31.9 kDa (GJD3);
(c) Paired related homeobox 1 (PRRX1); and
(d) Neuropilin 1 (NRP1).
80. A computer-implemented method according to any one of Claims 66 to 79 wherein the dataset in step (a) and the reference datasets are normalised.
81. A computer-implemented method according to any one of Claims 66 to 80 wherein said analytical process in step (b) comprises use of a predictive model which comprises the one or more reference datasets.
82. A computer-implemented method according to Claim 81 wherein said one or more reference datasets comprise quantitative data obtained from one or more individuals selected from a group consisting of healthy individuals, individuals diagnosed with Hodgkin's lymphoma who are responsive to chemotherapeutic drug treatment and individuals diagnosed with Hodgkin's lymphoma who are resistant to chemotherapeutic drug treatment. 83. A computer-implemented method according to any one of Claims 66 to 82 wherein said analytical process in step (b) comprises use of an adaptive learning algorithm.
84. A computer-implemented method according to Claim 83 wherein the adaptive learning algorithm is an artificial neural network.
85. A computer-implemented method according to Claim 84 wherein the artificial neural network is a multilayer perceptron. 86. A computer-implemented method according to any one of Claims 66 to 85 wherein the predictive model has an accuracy of at least 90% for classification.
87. A computer-implemented method according to Claim 86 wherein the predictive model has an accuracy of at least 95% for classification.
88. A computer-implemented method according to Claim 87 wherein the predictive model has an accuracy of at least 99% for classification.
89. A computer system for performing a computer-implemented method according to any one of Claims 66 to 88, wherein the system comprises a digital computer and
computer readable program means for enabling the computer to perform said computer-implemented method.
A computer system according to Claim 89 further comprising a computer- readable storage medium comprising reference datasets.
A computer-readable storage medium comprising computer readable program means for enabling the computer to perform a computer-implemented method according to any one of Claims 66 to 88.
A computer-readable storage medium according to Claim 91 further comprising reference datasets.
An in vitro method for determining the responsiveness of an individual with Hodgkin's lymphoma to chemotherapeutic drug treatment substantially as herein described with reference to the Examples.
A method for treating an individual with Hodgkin's lymphoma substantially as herein described with reference to the Examples.
An array substantially as herein described with reference to the Examples.
A kit substantially as herein described with reference to the Examples.
A computer-implemented method for classifying a sample from an individual with Hodgkin's lymphoma substantially as herein described with reference to the Examples.
A computer system substantially as herein described with reference to the Examples.
A computer-readable storage medium substantially as herein described with reference to the Examples.
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| WO2016141375A1 (en) * | 2015-03-05 | 2016-09-09 | Case Western Reserve University | Her2-regulated rna as diagnostic and therapeutic targets in her2-positive breast cancer |
| US10961589B2 (en) | 2015-03-05 | 2021-03-30 | Case Western Reserve University | HER2-regulated RNA as a diagnostic and therapeutic targets in HER2+ breast cancer |
| CN107217105A (en) * | 2017-07-27 | 2017-09-29 | 江苏省原子医学研究所 | A kind of cancer Combining diagnosis label and application thereof |
| CN107217105B (en) * | 2017-07-27 | 2020-10-20 | 江苏省原子医学研究所 | Cancer combined diagnosis marker and application thereof |
| EP3578981A1 (en) * | 2018-06-06 | 2019-12-11 | Technische Universität Dresden | Anti-cancer treatment of preselected subjects and screening methods to identify susceptible subjects |
| WO2019233779A1 (en) * | 2018-06-06 | 2019-12-12 | Technische Universität Dresden | Anti-cancer treatment of preselected subjects and screening methods to identify susceptible subjects |
| RU2688313C1 (en) * | 2018-10-02 | 2019-05-21 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации | Method for prediction of infertility after risk-adapted treatment of hodgkin lymphoma in children and adolescents |
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| WO2021228817A1 (en) | 2020-05-12 | 2021-11-18 | International Centre For Genetic Engineering And Biotechnology - Icgeb | Emid2 protein as anti-cancer treatment |
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| WO2014162008A3 (en) | 2015-01-08 |
| GB201306147D0 (en) | 2013-05-22 |
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