WO2013171458A3 - Cryogenic collisional cooling cell - Google Patents

Cryogenic collisional cooling cell Download PDF

Info

Publication number
WO2013171458A3
WO2013171458A3 PCT/GB2013/051191 GB2013051191W WO2013171458A3 WO 2013171458 A3 WO2013171458 A3 WO 2013171458A3 GB 2013051191 W GB2013051191 W GB 2013051191W WO 2013171458 A3 WO2013171458 A3 WO 2013171458A3
Authority
WO
WIPO (PCT)
Prior art keywords
ions
cooling
chamber
mass
cooling cell
Prior art date
Application number
PCT/GB2013/051191
Other languages
French (fr)
Other versions
WO2013171458A2 (en
Inventor
Jeffery Mark Brown
Jason Lee Wildgoose
Original Assignee
Micromass Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass Uk Limited filed Critical Micromass Uk Limited
Priority to US14/401,156 priority Critical patent/US9269554B2/en
Priority to JP2015512115A priority patent/JP2015521349A/en
Priority to EP13722019.0A priority patent/EP2850642A2/en
Publication of WO2013171458A2 publication Critical patent/WO2013171458A2/en
Publication of WO2013171458A3 publication Critical patent/WO2013171458A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H01J49/0481—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for collisional cooling
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H01J49/401—Time-of-flight spectrometers characterised by orthogonal acceleration, e.g. focusing or selecting the ions, pusher electrode

Abstract

A mass spectrometer is disclosed comprising a cooling cell (4) for cooling ions so as to reduce their kinetic energy. The cooling cell (4) comprises: a chamber for receiving the ions or for generating the ions therein, wherein said chamber is formed from walls defining a substantially enclosed region; and a cooling jacket (16) surrounding said chamber, wherein said cooling jacket (16) is arranged and configured to contain a cooling fluid and so as to remove heat from one or more walls of the chamber. The mass spectrometer further comprises a mass analyser (6) for receiving ions from the cooling cell (4) after they have been cooled. The present invention reduced the kinetic energy of the ions prior to mass analysis and hence improves the resolution of the mass analyser (6). The mass analyser is preferably a time of flight mass analyser.
PCT/GB2013/051191 2012-05-18 2013-05-08 Cryogenic collisional cooling cell WO2013171458A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US14/401,156 US9269554B2 (en) 2012-05-18 2013-05-08 Cryogenic collisional cooling cell
JP2015512115A JP2015521349A (en) 2012-05-18 2013-05-08 Cold collision cooling cell
EP13722019.0A EP2850642A2 (en) 2012-05-18 2013-05-08 Cryogenic collisional cooling cell

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1208812.6 2012-05-18
GBGB1208812.6A GB201208812D0 (en) 2012-05-18 2012-05-18 Cryogenic collision cell
US201261650018P 2012-05-22 2012-05-22
US61/650,018 2012-05-22

Publications (2)

Publication Number Publication Date
WO2013171458A2 WO2013171458A2 (en) 2013-11-21
WO2013171458A3 true WO2013171458A3 (en) 2014-11-13

Family

ID=46546321

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2013/051191 WO2013171458A2 (en) 2012-05-18 2013-05-08 Cryogenic collisional cooling cell

Country Status (5)

Country Link
US (1) US9269554B2 (en)
EP (1) EP2850642A2 (en)
JP (1) JP2015521349A (en)
GB (2) GB201208812D0 (en)
WO (1) WO2013171458A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103745905B (en) * 2014-01-06 2016-03-16 中国科学院化学研究所 A kind of particulate ion trap mass spectrometer with low-temperature charge detector
US20160372313A1 (en) * 2014-03-04 2016-12-22 Micromass Uk Limited Sample Introduction System for Spectrometers
US10192723B2 (en) * 2014-09-04 2019-01-29 Leco Corporation Soft ionization based on conditioned glow discharge for quantitative analysis
US10446384B2 (en) * 2015-04-25 2019-10-15 Dh Technologies Development Pte. Ltd. Fourier transform mass spectrometer
GB2567794B (en) * 2017-05-05 2023-03-08 Micromass Ltd Multi-reflecting time-of-flight mass spectrometers
US11817303B2 (en) 2017-08-06 2023-11-14 Micromass Uk Limited Accelerator for multi-pass mass spectrometers
WO2019030472A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov Ion mirror for multi-reflecting mass spectrometers
GB2573485B (en) 2017-11-20 2022-01-12 Thermo Fisher Scient Bremen Gmbh Mass spectrometer
GB2570435B (en) * 2017-11-20 2022-03-16 Thermo Fisher Scient Bremen Gmbh Mass spectrometer
US11443934B2 (en) 2018-05-23 2022-09-13 Shimadzu Corporation Time-of-flight mass spectrometry device
GB201808530D0 (en) 2018-05-24 2018-07-11 Verenchikov Anatoly TOF MS detection system with improved dynamic range
GB201808912D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808949D0 (en) * 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885470A (en) * 1987-10-05 1989-12-05 The United States Of America As Represented By The United States Department Of Energy Integrally formed radio frequency quadrupole
US5459315A (en) * 1993-11-18 1995-10-17 Shimadzu Corporation Quadrupole mass analyzer including spring-clamped heat sink plates
WO2002007185A1 (en) * 2000-07-13 2002-01-24 Advanced Research & Technology Institute Ion separation instrument
GB2451309A (en) * 2007-03-26 2009-01-28 Micromass Ltd An electron transfer dissociation cell comprising a plurality of apertured electrodes

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960761B2 (en) 1997-06-02 2005-11-01 Advanced Research & Technology Institute Instrument for separating ions in time as functions of preselected ion mobility and ion mass
US6104028A (en) * 1998-05-29 2000-08-15 Genetrace Systems Inc. Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
DE19913451C2 (en) * 1999-03-25 2001-11-22 Gsf Forschungszentrum Umwelt Gas inlet for generating a directed and cooled gas jet
WO2002101788A1 (en) * 2001-06-08 2002-12-19 Japan Science And Technology Corporation Cold spray mass spectrometric device
US7071467B2 (en) * 2002-08-05 2006-07-04 Micromass Uk Limited Mass spectrometer
US6875980B2 (en) * 2002-08-08 2005-04-05 Micromass Uk Limited Mass spectrometer
JP4555820B2 (en) * 2003-02-10 2010-10-06 ウオーターズ・テクノロジーズ・コーポレイシヨン Adsorption, detection and identification of ambient air components using desorption / ionization mass spectrometry (DIOS-MS) on silicon
EP1562041B1 (en) * 2004-01-22 2016-11-09 Thermo Finnigan Llc Apparatus and method for establishing a temperature gradient within a FAIMS analyzer region
EP1574849B1 (en) 2004-01-22 2012-09-26 Thermo Finnigan Llc Method and apparatus for FAIMS with a laser-based ionization source
US7365317B2 (en) * 2004-05-21 2008-04-29 Analytica Of Branford, Inc. RF surfaces and RF ion guides
JP5529379B2 (en) * 2004-10-28 2014-06-25 リザーランド，アルバート，エドワード Method and apparatus for separating isobaric interferences
GB2432712B (en) * 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
JP5142580B2 (en) * 2006-06-29 2013-02-13 キヤノン株式会社 Surface analysis method and surface analysis apparatus
US8384023B2 (en) * 2009-01-23 2013-02-26 Ionwerks, Inc. Post-ionization of neutrals for ion mobility oTOFMS identification of molecules and elements desorbed from surfaces
US8575544B1 (en) * 2010-03-22 2013-11-05 Cameca Instruments, Inc. Methods and devices for improving atom probe detector performance
GB201111569D0 (en) * 2011-07-06 2011-08-24 Micromass Ltd Apparatus and method of mass spectrometry

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885470A (en) * 1987-10-05 1989-12-05 The United States Of America As Represented By The United States Department Of Energy Integrally formed radio frequency quadrupole
US5459315A (en) * 1993-11-18 1995-10-17 Shimadzu Corporation Quadrupole mass analyzer including spring-clamped heat sink plates
WO2002007185A1 (en) * 2000-07-13 2002-01-24 Advanced Research & Technology Institute Ion separation instrument
GB2451309A (en) * 2007-03-26 2009-01-28 Micromass Ltd An electron transfer dissociation cell comprising a plurality of apertured electrodes

Also Published As

Publication number Publication date
EP2850642A2 (en) 2015-03-25
GB2506710B (en) 2016-09-07
GB2506710A (en) 2014-04-09
JP2015521349A (en) 2015-07-27
GB201308263D0 (en) 2013-06-12
WO2013171458A2 (en) 2013-11-21
US9269554B2 (en) 2016-02-23
US20150155149A1 (en) 2015-06-04
GB201208812D0 (en) 2012-07-04

Similar Documents

Publication Publication Date Title
WO2013171458A3 (en) Cryogenic collisional cooling cell
GB2511269A (en) High duty cycle ion spectrometer
WO2013064842A3 (en) Mass spectrometers comprising accelerator devices
GB2554181B (en) Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("REIMS") device
WO2013128023A3 (en) Method for operating a combined cycle power plant, and combined cycle power plant
WO2012141878A3 (en) High duty cycle ion storage/ion mobility separation mass spectrometer
GB202110454D0 (en) Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("REIMS") device
GB2556436A (en) Cell population analysis
WO2013093482A3 (en) An imaging mass spectrometer and a method of mass spectrometry
GB201204772D0 (en) Ion mobility spectrometer and method of measuring an ion mobility spectrum
WO2011150185A3 (en) Battery pack thermal protection from heat sterilization
PE20141514A1 (en) USE OF WHOLE SOFT AVOCADO TO OBTAIN AN AVOCADO OIL RICH IN NON-SAPONIFYABLE MASS
WO2012006114A3 (en) Fatty alcohol forming acyl reductases (fars) and methods of use thereof
GB2551669A (en) Physically guided rapid evaporative ionisation mass spectrometry ("Reims")
GB0618110D0 (en) Mass spectrometer
WO2012058248A3 (en) Extending the laserspray ionization mass spectrometry concept to vacuum
WO2013184207A3 (en) Emergency and back-up cooling of nuclear fuel and reactors
WO2016066267A3 (en) Laboratory centrifuge comprising a compressor-based cooling cycle, and method for operating a laboratory centrifuge comprising a compressor-based cooling cycle
WO2014086948A3 (en) Transformer assembly
WO2014057409A3 (en) Non-thermal plasma jet device as source of spatial ionization for ambient mass spectrometry and method of application
MX2013014421A (en) Process for the preparation of a metal complex in an oily organic matrix.
WO2014014925A3 (en) Sample encapsulation system and method
UA112828C2 (en) METAL THERMAL BATTERY
WO2013115727A8 (en) An anode material for ultrafast-charging lithium ion batteries and a method of its synthesis
EA201201074A1 (en) METHOD AND DEVICE FOR MANUFACTURE OF RADIATED ERICKS

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13722019

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 14401156

Country of ref document: US

ENP Entry into the national phase

Ref document number: 2015512115

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2013722019

Country of ref document: EP